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https://www.readbyqxmd.com/read/28929739/ultrasensitive-capture-detection-and-release-of-circulating-tumor-cells-using-nanochannel-ionchannel-hybrid-coupled-with-electrochemical-detection-technique
#1
Jing Cao, Xiao-Ping Zhao, Muhammad Rizwan Younis, Zhong-Qiu Li, Xing-Hua Xia, Chen Wang
With the growing demands of the early, accurate, and sensitive diagnosis for cancers, the development of new diagnostic technologies becomes increasingly important. In this study, we proposed a strategy for efficient capture and sensitive detection of circulating tumor cells (CTCs) using array nanochannel-ionchannel hybrid coupled with electrochemical detection technique. The aptamer probe was immobilized on the ionchannel surface to couple with the protein overexpressed on CTCs membrane. Through this special molecular recognition, CTCs can be selectively captured...
September 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28925689/highly-efficient-capture-and-electrochemical-release-of-circulating-tumor-cells-by-using-aptamers-modified-gold-nanowire-arrays
#2
Ting-Ting Zhai, Dekai Ye, Qian-Wen Zhang, Zeng-Qiang Wu, Xing-Hua Xia
The effectively capturing and releasing of circulating tumor cells (CTCs) is of significant importance in cancer prognose and treatment. Herein, we report a highly efficient method to capture and release human leukemic lymphoblasts (CCRF-CEM) using aptamers modified gold nanowire arrays (AuNWs). The gold nanowires, showing tunable morphologies from relatively random pillar deposit to uniform arrays, were fabricated by electrochemical deposition using anodic aluminum oxide (AAO) as template. Upon simply modification with aptamers by Au-S chemistry, the uniform AuNWs exhibit higher specificity to target cells...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28922542/a-diphenyldiselenide-derivative-induces-autophagy-via-jnk-in-htb-54-lung-cancer-cells
#3
Marta Díaz, Roncesvalles González, Daniel Plano, Juan Antonio Palop, Carmen Sanmartín, Ignacio Encío
Symmetric aromatic diselenides are potential anticancer agents with strong cytotoxic activity. In this study, the in vitro anticancer activities of a novel series of diarylseleno derivatives from the diphenyldiselenide (DPDS) scaffold were evaluated. Most of the compounds exhibited high efficacy for inducing cytotoxicity against different human cancer cell lines. DPDS 2, the compound with the lowest mean GI50 value, induced both caspase-dependent apoptosis and arrest at the G0 /G1 phase in acute lymphoblastic leucemia CCRF-CEM cells...
September 18, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28922126/functional-contour-following-via-haptic-perception-and-reinforcement-learning
#4
Randall B Hellman, Cem Tekin, Mihaela van der Schaar, Veronica J Santos
Many tasks involve the fine manipulation of objects despite limited visual feedback. In such scenarios, tactile and proprioceptive feedback can be leveraged for task completion. We present an approach for real-time haptic perception and decision-making for a haptics-driven, functional contour-following task: the closure of a ziplock bag. This task is challenging for robots because the bag is deformable, transparent, and visually occluded by artificial fingertip sensors that are also compliant. A deep neural net classifier was trained to estimate the state of a zipper within a robot's pinch grasp...
September 18, 2017: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/28920578/participation-in-physical-and-sportive-activities-among-adult-turkish-people-with-haemophilia-a-single-centre-experience
#5
Arni Lehmeier, Muhlis Cem Ar, Sevil Sadri, Mehmet Yürüyen, Zafer Başlar
No abstract text is available yet for this article.
September 18, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/28919757/once-monthly-paliperidone-palmitate-in-early-stage-schizophrenia-a-retrospective-non-interventional-1-year-study-of-patients-with-newly-diagnosed-schizophrenia
#6
Robin Emsley, Ludger Hargarter, Paul Bergmans, Boran Uglešić, Abdullah Cem Sengül, Antonino Petralia, Angelina Khannanova, Pierre Cherubin, Andreas Schreiner
BACKGROUND: Long-acting antipsychotic therapy may be best suited for patients in the early stage of schizophrenia, when the most can be done before disease progression associated with poor adherence occurs. We explored the patterns of use of once-monthly paliperidone palmitate (PP1M), concomitant medication use, hospitalization, and clinical outcomes of adult, newly diagnosed patients with schizophrenia receiving continuous treatment with PP1M for at least 12 months. METHODS: This was an international, multicenter, exploratory, retrospective chart review of medical records of adult patients who were newly diagnosed (not more than 1 year before initiation of PP1M treatment) with schizophrenia and who had received continuous treatment with PP1M for ≥12 months in naturalistic clinical settings...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28919097/j-pouch-vs-side-to-end-anastomosis-after-hand-assisted-laparoscopic-low-anterior-resection-for-rectal-cancer-a-prospective-randomized-trial-on-short-and-long-term-outcomes-including-life-quality-and-functional-results
#7
Nuri Okkabaz, Mustafa Haksal, Ali Emre Atici, Yunus Emre Altuntas, Ersin Gundogan, Fazli Cem Gezen, Mustafa Oncel
PURPOSE: To analyze the outcomes of j-pouch and side-to-end anastomosis in rectal cancer patients treated with laparoscopic hand-assisted low anterior resection. METHODS: Prospective trial on cases randomized to have a colonic j-pouch or a side-to-end anastomosis after low anterior resection. Demographics, characteristics of disease and treatment, perioperative results, and functional outcomes and life quality were compared between the groups. RESULTS: Seventy four patients were randomized...
September 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28917406/comparison-of-the-mechanical-properties-of-the-anterior-lens-capsule-in-senile-cataract-senile-cataract-with-trypan-blue-application-and-pseudoexfoliation-syndrome
#8
Cem Simsek, Sibel Oto, Gursel Yilmaz, Dilek Dursun Altinors, Ahmet Akman, Sirel Gur Gungor
PURPOSE: To evaluate the elastic modulus, hardness, and mechanical properties of the anterior lens capsule in different types of cataract and to assess the correlation with age. SETTING: Baskent University Hospital, Department of Ophthalmology, Ankara, Turkey. DESIGN: Prospective comparative study. METHODS: Patients were divided into 3 groups. Group 1 comprised patients with senile cataract, Group 2 patients had pseudoexfoliation (PXF) syndrome, and Group 3 patients had dye-enhanced cataract surgery...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28913123/true-management-of-obstructed-hemi-vagina-and-ipsilateral-renal-anomaly-syndrome
#9
Betül Yakıştıran, Yavuz Emre Şükür, Batuhan Turgay, Cem Atabekoğlu
Herlyn-Werner-Wunderlich syndrome is an unusual congenital anomaly of the female genitourinary system, which is described as uterine didelphys with Obstructed Hemi-vagina and Ipsilateral Renal Anomaly (OHIRA), also known as OHVIRA syndrome. Typical symptoms are pelvic pain, tenderness, pelvic mass due to blood collection in the obstructed hemi-vagina and uterus, and dysmenorrhea that usually begins shortly after menarche. Clinical suspicion is very important for diagnosis and correct management avoids both short- and long-term complications...
December 2016: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28902950/pre-emptive-evaluation-of-venom-allergy-in-a-patient-with-systemic-mastocytosis
#10
Theo Gülen, Cem Akin
No abstract text is available yet for this article.
September 13, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28901782/a-radiographic-dye-method-for-intraoperative-evaluation-of-syndesmotic-injuries
#11
Murad Pepe, Onur Kocadal, Zafer Gunes, Emre Calisal, Kubilay Ceritoglu, Cem Nuri Aktekin
BACKGROUND: The Chertsey test has been recently defined as an intraoperative test for the detection of the syndesmotic injuries by the application of intra-articular contrast. However, no study has investigated the reliability and comparative analysis of the Chertsey test. The purpose of this study was to explore the diagnostic accuracy of the Chertsey test in predicting syndesmosis instability of the injured ankle, with correlation to preoperative computed tomography (CT) findings. METHODS: A total of 39 patients who were operated on due to the unilateral ankle fracture and had no complaint on the contralateral ankle joint were included in the study...
September 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28900598/cationic-pegylated-polycaprolactone-nanoparticles-carrying-post-operation-docetaxel-for-glioma-treatment
#12
Cem Varan, Erem Bilensoy
Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development of drug delivery systems is important to treat brain tumors and prevent tumor recurrence. The aim of this study was to develop core-shell polymeric nanoparticles with positive charge by employing a chitosan coating. Additionally, an implantable formulation for the chemotherapeutic nanoparticles was developed as a bioadhesive film to be applied at the tumor site following surgical operation for brain glioma treatment...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28891796/-validation-of-the-spanish-version-of-the-pediatric-lower-urinary-tract-symptoms-scale-plutss
#13
Iván Somoza-Argibay, Roberto Méndez-Gallart, María Rodríguez-Ruíz, Inés Vergara, Sonia Pértega, Cem Akbal
OBJECTIVES: Lower Urinary Tract Dysfunction (LUTD) is the most common clinical problem in pediatric urology. To our knowledge non-validated instruments properly designed to screen lower urinary tract symptoms in the pediatric population has been translated and adapted to Spanish population. Pediatric Lower Urinary Tract Symptoms Score (PLUTSS) has proven to be a valid questionnaire for screening and evaluation of the response of children with LUTD to therapy. The aim of this study was to validate the PLUTSS questionnaire into Spanish, and put it to clinical use in pediatric patients, with cross-cultural equivalence to the original version...
September 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28891005/evaluation-of-the-internal-oblique-external-oblique-and-transversus-abdominalis-muscles-in-patients-with-ankylosing-spondylitis-an-ultrasonographic-study
#14
Ahmet Üşen, Banu Kuran, Figen Yılmaz, Neşe Aksu, Cem Erçalık
The objectives of the study are to compare abdominal muscle thickness in ankylosing spondylitis (AS) patients with healthy subjects and determine the factors affecting these muscle thickness. Thirty-five male patients with a previous diagnosis of AS according to the Modified New York criteria and a control group consisting of 35 healthy male individuals were included in this cross-sectional and case-control study. Thicknesses of the internal oblique (IO), external oblique (EO), and transversus abdominalis (TrA) muscles were measured with ultrasound (US)...
September 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28890427/blastocyst-transfer-does-not-improve-cycle-outcome-as-compared-to-d3-transfer-in-antagonist-cycles-with-an-elevated-progesterone-level-on-the-day-of-hcg
#15
Cem Demirel, Serkan Aydoğdu, Arzu İlknur Özdemir, Gülşah Keskin, Ercan Baştu, Faruk Buyru
OBJECTIVE: To evaluate the association between progesterone elevation on the day of human chorionic gonadotropin (hCG) administration and clinical pregnancy rates of gonadotropin-releasing hormone (GnRH) antagonist in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles with the transfer of embryos at different developmental stages (day-3 versus day-5 ETs). MATERIAL AND METHODS: This is a retrospective analysis of fresh IVF/ICSI; 194 cycles out of 2676 conducted in a single center...
September 1, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28887921/cytotoxicity-and-mode-of-action-of-a-naturally-occurring-naphthoquinone-2-acetyl-7-methoxynaphtho-2-3-b-furan-4-9-quinone-towards-multi-factorial-drug-resistant-cancer-cells
#16
Victor Kuete, Armelle T Mbaveng, Louis P Sandjo, Maen Zeino, Thomas Efferth
INTRODUCTION: Malignacies are still a major public concern worldwide and despite the intensive search of new chemotherapeutic agents, treatment still remains a challenging issue. The present study was designed to evaluate the cytotoxicity of 2-acetyl-7-methoxynaphtho[2,3-b]furan-4,9-quinone (AMNQ) isolated from the bark of Milletia versicolor towards a panel of drug-sensitive and multidrug-resistant (MDR) cancer cell lines. METHODS: The resazurin reduction assay was used to evaluate the cytotoxicity of AMNQ against 9 drug-sensitive and multidrug-resistant (MDR) cancer cell lines...
September 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28887172/synthesis-and-in-vitro-anticancer-activity-of-23-23-e-benzylidenespirostanols-derived-from-steroid-sapogenins
#17
Manuel A Ramos-Enríquez, Katherine Vargas-Romero, Lucie Rárová, Miroslav Strnad, Martín A Iglesias-Arteaga
Benzylidenespirostanols were prepared by two-step synthesis including BF3·Et2O-catalyzed aldol condensation of several acetylated steroid sapogenins with benzaldehyde followed by saponification. The obtained compounds showed moderate cytotoxicity against three cancer cell lines (T-lymphoblastic leukemia cell line CEM, breast carcinoma cell line MCF7 and cervical carcinoma cell line HeLa) and normal human fibroblasts (BJ). The most active of the five tested substances was 3c (lowest IC50 for MCF7 cells 19.9±0...
September 5, 2017: Steroids
https://www.readbyqxmd.com/read/28882060/mri-assessment-of-pituitary-iron-accumulation-by-using-pituitary-r2-in-%C3%AE-thalassemia-patients
#18
Mustafa Bozdağ, Selen Bayraktaroğlu, Yeşim Aydınok, Mehmet Cem Çallı
Background Patients with thalassemia major (TM) require repeated blood transfusions, which leads to accumulation of iron in a wide variety of tissues. Accumulation of iron in the pituitary gland can lead to irreversible hypogonadotropic hypogonadism (HH) in this group of patients. Purpose To investigate the reliability of pituitary-R2 as a marker to estimate the extent of pituitary iron load by comparing the pituitary magnetic resonance imaging (MRI) findings with hepatic iron load and serum ferritin levels...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28876600/comparative-assessment-of-in-hospital-trauma-mortality-at-a-south-african-trauma-centre-and-matched-patients-treated-in-the-united-states
#19
R Spence, J Scott, A Haider, P Navsaria, A Nicol
BACKGROUND: The unacceptably high rate of death and disability due to injury in sub-Saharan Africa is alarming. The objective of this work is to compare mortality rates between severely injured trauma patients at a high volume trauma centre in South Africa with matched patients in the United States. METHOD: Clinical databases from the Groote Schuur Hospital (GSH) for patients treated in Cape Town, South Africa and the American College of Surgeon's National Trauma Databank (NTDB) for patients treated at large academic trauma centres in the US were used...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28868797/effect-of-blood-contamination-on-the-compressive-strength-of-three-calcium-silicate-based-cements
#20
Mohammad S Sheykhrezae, Naghmeh Meraji, Fatemeh Ghanbari, Mohammad H Nekoofar, Behnam Bolhari, Paul M H Dummer
The aim of this study was to investigate the effect of human blood exposure on the compressive strength of various calcium silicate-based cements. Two hundred and eighty-eight customised cylindrical moulds were randomly divided into three groups according to material used: ProRoot MTA, Biodentine or CEM cement (n = 96). Each group was divided into two subgroups according to exposure conditions: PBS or blood. Then, the compressive strength of the specimens was measured after 6 h, 24 h, 72 h and 7 days...
September 3, 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
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