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https://www.readbyqxmd.com/read/29327460/nanocrystal-polymer-particles-extended-delivery-carriers-for-osteoarthritis-treatment
#1
Pierre Maudens, Christian Alexander Seemayer, Cédric Thauvin, Cem Gabay, Olivier Jordan, Eric Allémann
An efficient treatment for osteoarthritis (OA) can benefit from the local release of a high therapeutic dose over an extended period of time. Such a treatment will minimize systemic side effects and avoid the inconvenience of frequent injections. To this aim, nanocrystal-polymer particles (NPPs) are developed by combining the advantages of nanotechnology and microparticles. Nanocrystals are produced by wet milling kartogenin (KGN), which is known to promote chondrogenesis and to foster chondroprotection. A fluorescent biodegradable polymer is synthesized for intravital particle tracking...
January 12, 2018: Small
https://www.readbyqxmd.com/read/29327292/alterations-of-growth-rate-and-gene-expression-levels-of-upec-by-antibiotics-at-sub-mic
#2
Defne Gümüş, Fatma Kalaycı-Yüksek, Emre Yörük, Gülşen Uz, Eşref Çelik, Cansu Arslan, Elif Merve Aydın, Cem Canlı, Mine Anğ-Küçüker
The host is the main environment for bacteria, and they also expose to many antibiotics during the treatment of infectious diseases in host body. In this study, it was aimed to investigate possible changes in growth rate and expression levels of three virulence genes (foc/foc, cnf1, and usp) in a uropathogenic E. coli standard strain within the presence of ciprofloxacin, nitrofurantoin, and trimethoprim-sulfamethoxazole. The UPEC C7 strain was grown on tryptic soy broth-TSB (control), TSB + ciprofloxacin, TSB + nitrofurantoin, and TSB + trimethoprim-sulfamethoxazole for determination of both growth rate and gene expression level...
January 11, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29326099/interleukin-18-diagnostically-distinguishes-and-pathogenically-promotes-human-and-murine-macrophage-activation-syndrome
#3
Eric S Weiss, Charlotte Girard-Guyonvarc'h, Dirk Holzinger, Adriana A de Jesus, Zeshan Tariq, Jennifer Picarsic, Eduardo J Schiffrin, Dirk Foell, Alexei A Grom, Sandra Ammann, Stephan Ehl, Tomoaki Hoshino, Raphaela Goldbach-Mansky, Cem Gabay, Scott W Canna
Hemophagocytic Lymphohistiocytosis (HLH) and Macrophage Activation Syndrome (MAS) are life-threatening hyperferritinemic systemic inflammatory disorders. Though profound cytotoxic impairment causes familial HLH (fHLH), the mechanisms driving non-fHLH and MAS are largely unknown. MAS occurs in patients with suspected rheumatic disease, but the mechanistic basis for its distinction is unclear. Recently, a syndrome of recurrent MAS with infantile enterocolitis caused by NLRC4 inflammasome hyperactivity highlighted the potential importance of Interleukin (IL)-18...
January 11, 2018: Blood
https://www.readbyqxmd.com/read/29325972/antioxidant-activity-of-cape-caffeic-acid-phenethyl-ester-in-vitro-can-protect-human-sperm-deoxyribonucleic-acid-from-oxidative-damage
#4
Şule Ayla, Gülden Tunalı, Bülent E Bilgiç, Kenan Sofuoğlu, A Arman Özdemir, Gamze Tanrıverdi, Semra Özdemir, B Cem Soner, Bahar Öztürk, Serçin Karahüseyinoğlu, Esra Güler Aslan, Ismail Seçkin
PURPOSE: Sperm processing (e.g., centrifugation) used in preparation for assisted reproduction can result in excessive generation of reactive oxygen species (ROS) and potential sperm damage. The use of antioxidants during sperm processing has been shown to prevent iatrogenic sperm damage, including DNA damage. In this study, we evaluated the effect of caffeic acid phenethyl ester (CAPE) on oxidative stress mediated sperm dysfunction and DNA damage. METHODS: Semen samples were obtained to liquefy at room temperature...
January 8, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29322966/the-influence-of-adjunctive-caudal-epidural-steroid-injection-on-the-therapeutic-effect-of-transforaminal-epidural-steroid-injection
#5
Atilla Kircelli, Tufan Cansever, Cem Yılmaz
BACKGROUND: Epidural steroid injection is widely used to treat the short and long-term symptoms of low back and radicular pain. To the best of our knowledge, the influence of transforaminal epidural steroid injection (TFSI) combined with caudal epidural steroid injection (CESI) on pain intensity, patient satisfaction, and quality of life in lumbar radiculopathy has not been examined. AIM: To evaluate the short and long-term efficacy of TFSI, and TFSI combined with CESI (TFSI + CESI) in patients with lumbar radiculopathy...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29321709/the-probable-prevalence-and-sociodemographic-characteristics-of-specific-learning-disorder-in-primary-school-children-in-edirne
#6
Işık Görker, Leyla Bozatli, Ümran Korkmazlar, Meltem Yücel Karadağ, Cansın Ceylan, Ceren Söğüt, Hasan Cem Aykutlu, Büşra Subay, Nesrin Turan
Introduction: The aim of this study was to research the probable prevalence of Specific Learning Disorder (SLD) in primary school children in Edirne City and the relationships with their sociodemographic characteristics. Methods: The sample of our study was composed of 2,174 children who were educated in primary schools in second, third, and fourth grades in the academic year 2013-2014 in Edirne City. The teachers and parents of these children were given Specific Learning Difficulties Symptom Scale, Learning Disabilities Symptoms Checklist (teacher and parent forms), and sociodemographic data forms to fill in...
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29316537/picolyl-amides-of-betulinic-acid-as-antitumor-agents-causing-tumor-cell-apoptosis
#7
Uladzimir Bildziukevich, Lucie Rárová, David Šaman, Zdeněk Wimmer
A series of picolyl amides of betulinic acid (3a-3c and 6a-6c) was prepared and subjected to the cytotoxicity screening tests. Structure-activity relationships studies resulted in finding differences in biological activity in dependence on o-, m- and p-substitution of the pyridine ring in the target amides, when cytotoxicity data of 3a-3c and 6a-6c were obtained and compared. The amides 3b and 3a displayed cytotoxicity (given in the IC50 values) in G-361 (0.5 ± 0.1 μM and 2.4 ± 0.0 μM, respectively), MCF7 (1...
January 4, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29309859/cytotoxic-activity-of-medicinal-plants-of-the-kakamega-county-kenya-against-drug-sensitive-and-multidrug-resistant-cancer-cells
#8
Dominic O Ochwang'i, Charles N Kimwele, Jemimah A Oduma, Peter K Gathumbi, Stephen G Kiama, Thomas Efferth
ETHNOPHARMACOLOGICAL RELEVANCE: The geographical location of Kakamega County proximal to the Kakamega Rain Forest in Kenya and its rich flora represents an interesting resource of traditional medicinal plants. The medicinal plants in the present study are traditionally used to treat cancer in Kakamega County as recorded in published literature. AIM OF THE STUDY: Due to multidrug resistance (MDR) and severe side effects of currently used drugs in clinical oncology, new candidate compounds are urgently required to improve treatment outcome...
January 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29306964/higher-schizotypy-predicts-better-metabolic-profile-in-unaffected-siblings-of-patients-with-schizophrenia
#9
E Cem Atbasoglu, Guvem Gumus-Akay, Sinan Guloksuz, Meram Can Saka, Alp Ucok, Koksal Alptekin, Sevim Gullu, Jim van Os
RATIONALE: Type 2 diabetes (T2D) is more frequent in schizophrenia (Sz) than in the general population. This association is partly accounted for by shared susceptibility genetic variants. OBJECTIVE: We tested the hypotheses that a genetic predisposition to Sz would be associated with higher likelihood of insulin resistance (IR), and that IR would be predicted by subthreshold psychosis phenotypes. METHODS: Unaffected siblings of Sz patients (n = 101) were compared with a nonclinical sample (n = 305) in terms of IR, schizotypy (SzTy), and a behavioural experiment of "jumping to conclusions"...
January 6, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29306491/effect-of-air-bubbles-localization-and%C3%A2-migration-after-embryo-transfer%C3%A2-on%C3%A2-assisted-reproductive-technology-outcome
#10
Cem Fıçıcıoğlu, Pınar Özcan, Melis G Koçer, Mert Yeşiladalı, Oya Alagöz, Gülçin Özkara, Ahter T Tayyar, Çiğdem Altunok
OBJECTIVE: To evaluate the effect of embryo flash position and movement of the air bubbles at 1 and 60 minutes after ET on clinical pregnancy rates (PRs). DESIGN: Prospective clinical trial. SETTING: University fertility clinic. PATIENT(S): A total of 230 fresh ultrasound-guided ETs performed by a single physician (C.F.) at the IVF center of Yeditepe University Hospital between September 2016 and February 2017 were included...
January 3, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29303887/correlation-between-postoperative-central-corneal-thickness-and-endothelial-damage-after-cataract-surgery-by-phacoemulsification
#11
Jean Marc Perone, Mathilde Boiche, Louis Lhuillier, Francis Ameloot, Shamour Premy, Anne-Laure Jeancolas, Christophe Goetz, Estelle Neiter
PURPOSE: To study the correlation between postoperative corneal edema and endothelial cell loss after cataract surgery by microcoaxial phacoemulsification. METHODS: Eighty-five eyes of 85 consecutive patients with mild cataract (up to C5, N4, and P5: per LOCS III classification) were included in a prospective study from September 2014 to November 2014. Eighty-five eyes were necessary to obtain a precision of 0.15 for computation of the Pearson correlation coefficient...
January 4, 2018: Cornea
https://www.readbyqxmd.com/read/29302998/the-effects-of-mucosal-media-on-some-pathogenic-traits-of-crohn-s-disease-associated-escherichia-coli-lf82
#12
Husamettin Aygun, Murat Karamese, Cem Ozic, Fikret Uyar
AIM: Adherent-invasive Escherichia coli (AIEC) pathovar has been identified in intestinal mucosa of patients with Crohn's disease. Our aim was to compare the impact of sterile mucosal media (Muc-M) originated from different parts of the intestine on some pathogenic traits of AIEC LF82 strain. MATERIALS & METHODS: Muc-M composed of certain rates of cell culture medium or M63 minimal medium and mucosal contents obtained from different part of intestine were designed for cell-infection experiments and biofilm-formation assays...
January 5, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29301693/the-relation-between-melanism-and-thermal-biology-in-a-colour-polymorphic-bush-cricket-isophya-rizeensis
#13
Arda Cem Kuyucu, Mehmet Kursat Sahin, Selim Sualp Caglar
According to the thermal melanism hypothesis, darker coloured melanic individuals heat up faster and to higher temperatures than lighter coloured individuals due to lower skin reflectance. Consequently, it is assumed that darker melanic types may be advantageous compared to light coloured types in colder regions. As temperature gradually decreases with elevation and latitude the degree of melanism is expected to increase along these gradients in ectothermic species. Isophya rizeensis, a colour polymorphic bush cricket species endemic to Northeastern Turkey is an interesting case since the degree of melanism decreases with elevation, contrary to the thermal melanism hypothesis...
January 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29300516/clinical-features-and-management-of-dacryops
#14
Cem Ozgonul, Yusuf Uysal, Onder Ayyildiz, Murat Kucukevcilioglu
PURPOSE: To describe clinical, imaging findings, and management of dacryops cases. METHODS: A retrospective chart review was performed to identify the patients diagnosed with dacryops over a 5-year period. The clinical features based on clinical findings, computerized tomography and ultrasonography, and observation and surgical excision results were noted when available. RESULTS: We included 14 eyes of 14 patients. Seven (50%) were men with a median age of 48 years...
January 4, 2018: Orbit
https://www.readbyqxmd.com/read/29295842/unopposed-il-18-signaling-leads-to-severe-tlr9-induced-macrophage-activation-syndrome-in-mice
#15
Charlotte Girard-Guyonvarc'h, Jennifer Palomo, Praxedis Martin, Emiliana Rodriguez, Sabina Troccaz, Gaby Palmer, Cem Gabay
The term macrophage activation syndrome (MAS) defines a severe, potentially fatal disorder characterized by overwhelming inflammation and multiorgan involvement. Interleukin (IL)-18 is a pro-inflammatory cytokine belonging to the IL-1 family, the activity of which is regulated by its endogenous inhibitor IL-18 binding protein (IL-18BP). Elevated IL-18 levels have been reported in patients with MAS. Herein we show that upon repeated toll-like receptor (TLR)9 stimulation with CpG, IL-18BP-/- mice display severe MAS manifestations, including increased weight loss, splenomegaly, anemia, thrombocytopenia, hyperferritinemia and bone marrow hemophagocytosis as compared to wild-type mice...
January 2, 2018: Blood
https://www.readbyqxmd.com/read/29290539/is-acl-reconstruction-a-prerequisite-for-the-patients-having-recreational-sporting-activities
#16
Emrah Kovalak, Tolga Atay, Cem Çetin, I Meltem Atay, Mustafa Onur Serbest
OBJECTIVE: Whether surgical or conservative treatment is more effective in allowing patients to return to physical activity after anterior cruciate ligament (ACL) injury is controversial. We sought to compare mid-term outcome measures between isolated ACL tear patients who underwent reconstruction followed by closed kinetic chain exercises and those who underwent neuromuscular training only. METHODS: We retrospectively evaluated patients with ACL tears who underwent post-surgery CKC strength training after ACL reconstruction (Group A), and patients who only underwent neuromuscular training (Group B) with a minimum follow-up time of 5 years...
December 28, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29282220/inflammasome-adaptor-asc-suppresses-apoptosis-of-gastric-cancer-cells-by-an-il-18-mediated-inflammation-independent-mechanism
#17
Brendan J Jenkins, Virginie Deswaerte, Paul M Nguyen, Alison West, Alison F Browning, Liang Yu, Saleela Ruwanpura, Jesse Balic, Thaleia Livis, Charlotte Girard, Adele Preaudet, Hiroko Oshima, Ka Yee Fung, Hazel Tye, Meri Najdovska, Matthias Ernst, Masanobu Oshima, Cem Gabay, Tracy L Putoczki
Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and autoimmune diseases, but their role in inflammation-associated tumorigenesis remains ill-defined. Here we reveal a pro-tumorigenic role in gastric cancer (GC) for the key inflammasome adaptor ASC and its effector cytokine IL-18. Genetic ablation of ASC in the gp130F/F spontaneous mouse model of intestinal-type GC suppressed tumorigenesis by augmenting caspase-8-like apoptosis in the gastric epithelium, independently from effects on myeloid cells and mucosal inflammation...
December 27, 2017: Cancer Research
https://www.readbyqxmd.com/read/29280933/percutaneous-kyphoplasty-is-bilateral-approach-necessary
#18
Atilla Yılmaz, Mürteza Çakır, Cem Şeyho Yücetaş, Boran Urfalı, Necati Üçler, Murat Altaş, Mustafa Aras, Yurdal Serarslan, Rahmi Kemal Koç
STUDY DESIGN: A multicenter retrospective study of patients who underwent unilateral and bilateral balloon kyphoplasty. OBJECTIVE: The aim of this study was to compare the radiographic and clinical results of unilateral and bilateral balloon kyphoplasty to treat osteoporotic vertebral compression fractures. SUMMARY OF BACKGROUND DATA: Percutaneous kyphoplasty has long been used as a successful method in the treatment of osteoporotic vertebral compression fractures...
December 26, 2017: Spine
https://www.readbyqxmd.com/read/29278703/overexpression-of-lhx2-suppresses-proliferation-of-human-t-cell-acute-lymphoblastic-leukemia-derived-cells-partly-by-reducing-lmo2-protein-levels
#19
Kazuya Miyashita, Kenji Kitajima, Susumu Goyama, Toshio Kitamura, Takahiko Hara
T cell acute lymphoblastic leukemia (T-ALL) is a malignant cancer with poor prognosis. The transcriptional co-factor LIM domain only 2 (LMO2) and its target gene HHEX are essential for self-renewal of T cell precursors and T-ALL etiology. LMO2 directly associates with LDB1 in a large DNA-containing nuclear complex and controls the transcription of T-ALL-related genes. Recently, we reported that overexpression of the LIM-homeodomain transcription factor, Lhx2, results in liberation of the Lmo2 protein from the Lmo2-Ldb1 complex, followed by ubiquitin proteasome mediated degradation...
December 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29277880/robot-assisted-radical-prostatectomy-in-a-patient-with-previous-abdominoperineal-resection-and-pelvic-external-beam-radiation-therapy
#20
Basatac Cem, Akpinar Haluk
Though previous major abdominal surgery and pelvic irradiation may be a significant drawback of subsequent laparoscopic procedure, technological advances such as better visualization and more controlled finer movementsof robotic arms allowing better dissection in robotic-assisted laparoscopic surgery may reduce some of these challenges. However, limited data are available on the effect and safety of robotic surgery in these patients. The aim of this case report is to present efficacy and safety of robot assisted radical prostatectomy in a patient who has rectal and concurrent prostate cancer with the history of abdominoperineal resection, pelvic irradiation and adjuvantchemotherapy...
December 26, 2017: Urology Journal
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