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https://www.readbyqxmd.com/read/28635254/sudoku-like-lab-on-paper-cyto-device-with-dual-enhancement-of-electrochemiluminescence-intermediates-strategy
#1
Hongmei Yang, Yan Zhang, Li Li, Lina Zhang, Feifei Lan, Jinghua Yu
This paper describes the design and construction of sudoku-like lab-on-paper platform, in which dual enhancement of reaction intermediates strategy was incorporated for multiplexed competitive electrochemiluminescence (ECL) cyto-assay. Benefit from the sudoku-like structure, integrated multifunction were obtained on such elaborately devised platform, including specific reagents storage, multiple samples immobilization, residual automatic washing, and signal collection. By utilizing semicarbazide (SE) and silver nanoparticles (AgNPs) as dual enhancers, more ECL intermediates could be obtained in the graphene quantum dots (GQDs) and peroxydisulfate system, resulting in the production of more excited state GQDs to emit light...
June 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28632812/systemic-interferon-alfa-injections-for-the-treatment-of-a-giant-orf
#2
Sumeyre Seda Ertekin, Mehmet Salih Gurel, Aslı Vefa Turgut Erdemir, Cem Leblebici
Orf is a zoonotic infection caused by a parapoxvirus and is endemic in sheep and goats. It may be transmitted to humans by direct contact with infected animals. We report a case of a giant orf in a patient with chronic lymphocytic leukemia (CLL), which proliferated dramatically after surgical excision and resolved after systemic interferon alfa-2a injections.
May 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28632185/the-effects-of-selected-sesquiterpenes-from-myrica-rubra-essential-oil-on-the-efficacy-of-doxorubicin-in-sensitive-and-resistant-cancer-cell-lines
#3
Martin Ambrož, Petra Matoušková, Adam Skarka, Martina Zajdlová, Kateřina Žáková, Lenka Skálová
β-caryophyllene oxide (CAO), α-humulene (HUM), trans-nerolidol (NER) and valencene (VAL) are constituents of the essential oil of Myrica rubra (MEO), which has significant antiproliferative effect in various cancer cell lines. In the present study, we compared the antiproliferative effect of these sesquiterpenes alone and in combination with the cytostatic drug doxorubicin (DOX) in cancer cell lines with different sensitivity to DOX. Two ovarian cancer cell lines (sensitive A2780 and partly resistant SKOV3) and two lymphoblast cancer cell lines (sensitive CCRF/CEM and completely resistant CEM/ADR) were used...
June 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28631496/echocardiographic-evaluation-of-cardiac-functions-in-newborns-of-mildly-preeclamptic-pregnant-women-within-postnatal-24-48%C3%A2-hours
#4
Kadir Mutlu, Ulas Karadas, Yilmaz Yozgat, Timur Meşe, Mustafa Demirol, Senay Coban, Cem Karadeniz, Rahmi Özdemir, Dilek Orbatu, Utku Karaarslan, Vedide Tavli
The aim of this study is to detect preeclampsia-related cardiac dysfunction within 24-48 hours of delivery in newborns born from preeclamptic mothers. Forty newborns from mildly preeclamptic mothers formed the study group and the control group was formed by 40 healthy newborns. Cardiac function for the groups were evaluated using conventional echocardiography and myocardial performance index (MPI) within the first 24-48 hours of their lifetime and the results of both groups were compared. A significant difference between the groups was observed especially in the PW Doppler MPI measurements (the left ventricle MPI 0...
June 20, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28626851/counselling-pregnant-women-at-the-crossroads-of-europe-and-asia-effect-of-teratology-information-service-in-turkey
#5
Yusuf Cem Kaplan, Barış Karadaş, Gözde Küçüksolak, Bartu Ediz, Ömer Demir, Kaan Sozmen, Hedvig Nordeng
Background Previous studies from western countries demonstrated the effectiveness of Teratology Information Service (TIS) counselling in reducing the teratogenic risk perception of pregnant women. Objective To assess whether TIS counselling would be effective in reducing the teratogenic risk perception of the Turkish pregnant women. Setting A TIS (Terafar) operating in a university hospital in Turkey. Methods A cross-sectional survey study. Pregnant women with non-teratogenic medication exposures were asked to assign scores on visual analogue scales (VAS) in response to the questions aiming to measure their teratogenic risk perception...
June 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28625006/butterfly-cartilage-tympanoplasty-an-alternative-new-technique-instead-of-conventional-surgery-method
#6
Isa Kaya, Murat Benzer, Sercan Gode, Cem Bilgen, Tayfun Kirazli
Butterfly graft inlay tympanoplasty is a well-established technique for the repair of small- and medium-sized perforations. There are some difficulties with application of conventional butterfly technique and it affects our success rate of graft healing. With some modifications of graft preparation we can make better success rates. The aim of this study was to present the new renovation of conventional method, describe about what kind of changes we made and its technical facilities about the procedure. The study design is a prospective case series...
June 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28624547/regioselective-monoalkylation-of-17%C3%AE-estradiol-for-the-synthesis-of-cytotoxic-estrogens
#7
Koen Van Gansbeke, Eirik Johansson Solum, Sandra Liekens, Anders Vik, Trond Vidar Hansen
The regioselective synthesis of estrogens and their derivatives continues to be of interest. Most reported syntheses require multistep protocols associated with poor overall yield and lack of regioselectivity. New preparative protocols are still desired. Herein, 11 2-alkylated 17β -estradiol analogs were synthesized in a highly regioselective manner. The products were obtained using a convenient, one pot and high-yielding protocol. The anti-proliferative activity of the compounds was tested in human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human dermal microvascular endothelial (HMEC-1) cells...
June 14, 2017: Steroids
https://www.readbyqxmd.com/read/28622915/turkish-validity-and-reliability-of-eustachian-tube-dysfunction-questionnaire-7
#8
Erdoğan Özgür, Cem Bilgen, Beyhan Cengiz Özyurt
INTRODUCTION: During clinical evaluations, in order to interpret patients' complaints caused by Eustachian Tube Dysfunction and to monitor the success of the treatment, standardized and disease-related scales are necessary. OBJECTIVE: The aim of this study was to investigate the validity and reliability of the Turkish version of Eustachian Tube Dysfunction Questionnaire-7. METHODS: Forty patients diagnosed with Eustachian Tube Dysfunction and 40 healthy individuals were enrolled for the study...
May 31, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28618020/bacterial-colonization-of-resin-composite-cements-influence-of-material-composition-and-surface-roughness
#9
Stephanie Glauser, Monika Astasov-Frauenhoffer, Johannes A Müller, Jens Fischer, Tuomas Waltimo, Nadja Rohr
So-called secondary caries may develop in the cement gap between the tooth and the bonded restoration. Cement materials with a low susceptibility to biofilm formation are therefore desirable. In the present study, the adhesion of Strepococcus mutans onto three adhesive (Multilink Automix, RelyX Ultimate, and Panavia V5) and three self-adhesive (Multilink Speed Cem, RelyX Unicem 2 Automix, and Panavia SA plus) resin composite cements was evaluated. Previous studies have failed to evaluate concomitantly the effect of both the composition of the cements and their surface roughness on biofilm formation...
June 15, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28613013/post-traumatic-stress-disorder-among-mothers-whose-children-underwent-oncological-surgery
#10
Kıvılcım Karadeniz Cerit, Cem Cerit, Ömer Nart, Nurşah Eker, Gürsu Kıyan, Tolga Dağlı, Gülşen Ekingen, Gülnur Tokuç, Ömer Karaca, Funda Çorapçıoğlu
BACKGROUND: The aim of this study was to investigate the rate of post-traumatic stress disorder (PTSD) and associated risk factors among mothers whose children underwent oncological surgery. METHOD: This cross-sectional, multi-center study included a total of 60 mothers whose children underwent major thoracoabdominal surgery and were under the follow-up in the outpatient setting between February 2016 and May 2016. Clinical Data Form, Hospital Anxiety and Depression Scale (HADS), and Clinician-Administered PTSD scale (CAPS) were used...
June 14, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28604459/definitive-chemoradiotherapy-in-elderly-cervical-cancer-patients-a-multiinstitutional-analysis
#11
Ozan Cem Guler, Sezin Yuce Sari, Sumerya Duru Birgi, Melis Gultekin, Ferah Yildiz, Cem Onal
OBJECTIVE: The aim of the study was to investigate the prognostic factors for survival and treatment-related toxicities in older (≥65 years) cervical cancer patients treated with definitive chemoradiotherapy. In addition, we sought to compare the outcomes between the older elderly (≥75 years) and their younger old counterparts (age, 65-74 years). MATERIALS AND METHODS: We retrospectively reviewed medical records from 269 biopsy-proven nonmetastatic cervical cancer patients treated with external radiotherapy and intracavitary brachytherapy at the departments of radiation oncology in 2 different universities...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28598700/comment-and-response-to-the-significance-of-early-warning-in-chronic-myeloid-leukemia
#12
Ahmet Emre Eskazan, Muhlis Cem Ar, Teoman Soysal
No abstract text is available yet for this article.
June 15, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28596142/amphiphilic-cyclodextrin-nanoparticles
#13
Gamze Varan, Cem Varan, Nazlı Erdoğar, A Atilla Hıncal, Erem Bilensoy
Cyclodextrins are cyclic oligosaccharides obtained by enzymatic digestion of starch. The α-, β- and γ- cyclodextrins contain respectively 6, 7 and 8 glucopyranose units, with primary and secondary hydroxyl groups located on the narrow and wider rims of a truncated cone shape structure. Such structure is that of a hydrophobic inner cavity with a hydrophilic outer surface allowing to interact with a wide range of molecules like ions, protein and oligonucleotides to form inclusion complexes. Many cyclodextrin applications in the pharmaceutical area have been widely described in the literature due to their low toxicity and low immunogenicity...
June 5, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28595798/mineral-content-of-smooth-scallop-flexopecten-glaber-caught-canakkale-turkey-and-evaluation-in-terms-of-food-safety
#14
Nermin Berik, Ekrem Cem Çankırılıgil, Güzin Gül
In this research, one of the most promising scallop species, smooth scallop (Flexopecten glaber) was studied. According to our findings, smooth scallop has beneficial micro and macro minerals, fat and carbohydrate just before the spawning. While the ratios protein, ash and water decreased from autumn to summer, ratio of crude fat increased till reproduction season in late spring and decreased in summer (P<0.05). In digestive glands, aluminum, bromine, cadmium, calcium, chromium, copper, iron, manganese, nickel, and zinc were detected more compared to adductor muscles (P<0...
July 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28594316/effects-of-irisin-and-exercise-on-metabolic-parameters-and-reproductive-hormone-levels-in-high-fat-diet-induced-obese-female-mice
#15
Ercan Bastu, Umit Zeybek, Ebru Gurel Gurevin, Bahar Yüksel Ozgor, Faruk Celik, Nazli Okumus, Irem Demiral, Ozlem Dural, Cem Celik, Huri Bulut, Elif Ilkay Armutak, Bulent Baysal, Faruk Buyru, John Yeh
It has been documented that exogenously administered irisin (10(10) fibronectin-type III domain-containing 5 [FNDC5]), which is a new polypeptide hormone, induces the browning of subcutaneous fat and thermogenesis. In this study, effects of physical activity and exogenous administration of irisin were investigated on parameters related with reproduction and metabolism in the high-fat diet-induced obesity model of the female C57BL/6J mice. Sixty mice were gathered at age approximately 5 to 6weeks and were divided into 3 groups...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28589180/treatment-of-pilonidal-disease-by-phenol-application
#16
REVIEW
Mustafa Emiroğlu, Cem Karaali, Hüseyin Esin, Göksever Akpınar, Cengiz Aydın
The literature indicates various approaches regarding the properties of phenol, the target patient group, and the complication and recurrence rates. Although phenol is most frequently used to treat the fistulated form of the disease, it can also be applied for other types. The overall success and complication rates of the application is reported as 62-95% and 0%-2%, respectively. Phenol treatment in pilonidal disease can be used more frequently as an alternative method with acceptable success, complication, and recurrence rates...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28587882/combined-vitrectomy-and-glaucoma-drainage-device-implantation-surgical-approach-for-complex-pediatric-glaucomas
#17
Cem Ozgonul, Cagri G Besirli, Brenda L Bohnsack
PURPOSE: To evaluate efficacy of combined vitrectomy with posteriorly-placed glaucoma drainage device (GDD) in lowering intraocular pressure (IOP) in children. PATIENTS AND METHODS: Retrospective case review identified 20 children who underwent vitrectomy with posteriorly-placed GDD with minimal 6-months follow-up. First eye operated on was included. Success was defined as IOP 5-20 mmHg, no additional IOP-lowering surgery or visually-devastating complications. RESULTS: Patients with primary infantile-onset glaucoma (25%), traumatic glaucoma (15%), Peters anomaly (15%), microphthalmia (25%), glaucoma following cataract surgery (10%), microspherophakia (5%), and retinopathy of prematurity (5%) were included...
June 3, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28586017/kml001-and-doxercalciferol-induce-synergistic-antileukemic-effect-in-acute-lymphoid-leukemia-cells
#18
Yang Liu, Dong-Yeop Shin, Somi Oh, Sujong Kim, Youngil Koh, Inho Kim
KML001 (NaAsO2, sodium metaarsenite, KOMINOX), a kind of arsenic compound, that has shown promising efficacy in non-Hodgkin's lymphoma (NHL) both in vitro and in vivo. In our study, the antileukemic effect of KML001 on acute lymphoid leukemia (ALL) and its mechanism of action were investigated. The results showed that KML001 inhibited cell proliferation in two types of ALL cell lines, CCRF-CEM and Molt-4. Exposure of ALL cells to KML001 induced apoptosis in a time-dependent manner. KML001 caused cell cycle arrest at G2/M phase instead of G0/G1 phase shown in other leukemia cells...
June 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28584381/cutaneous-angiosarcoma-mimicking-panniculitis-in-the-lower-extremities
#19
Sumeyre Seda Ertekin, Ezgi Ozkur, Cem Leblebici, Mehmet Salih Gürel, Asli Vefa Turgut Erdemir
No abstract text is available yet for this article.
May 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28582465/differential-regulation-of-cell-death-pathways-by-the-microenvironment-correlates-with-chemoresistance-and-survival-in-leukaemia
#20
Malak Yahia Qattan, Emyr Yosef Bakker, Ramkumar Rajendran, Daphne Wei-Chen Chen, Vaskar Saha, Jizhong Liu, Leo Zeef, Jean-Marc Schwartz, Luciano Mutti, Constantinos Demonacos, Marija Krstic-Demonacos
Glucocorticoids (GCs) and topoisomerase II inhibitors are used to treat acute lymphoblastic leukaemia (ALL) as they induce death in lymphoid cells through the glucocorticoid receptor (GR) and p53 respectively. Mechanisms underlying ALL cell death and the contribution of the bone marrow microenvironment to drug response/resistance remain unclear. The role of the microenvironment and the identification of chemoresistance determinants were studied by transcriptomic analysis in ALL cells treated with Dexamethasone (Dex), and Etoposide (Etop) grown in the presence or absence of bone marrow conditioned media (CM)...
2017: PloS One
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