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https://www.readbyqxmd.com/read/29778528/molecular-modeling-synthesis-antibacterial-and-cytotoxicity-evaluation-of-sulfonamide-derivatives-of-benzimidazole-indazole-benzothiazole-and-thiazole
#1
Farha Naaz, Ritika Srivastava, Anuradha Singh, Nidhi Singh, Rajesh Verma, Vishal K Singh, Ramendra K Singh
A new series of heterocyclic molecules bearing sulfonamide linkage has been synthesized and screened for antibacterial activity. During antibacterial screening using broath dilution method, molecules were found to be highly active (MIC value 50-3.1 µg/mL) against different human pathogens, namely B. cerus, S. aureus, E. coli and P. aeruginosa, and most effective against E. coli. A great synergistic effect was observed during determination of FIC where molecules were used in combination with reference drugs chloramphenicol and sulfamethoxazole...
May 11, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29772899/honeycomb-like-plga-b-peg-structure-creation-with-t-junction-micro-droplets
#2
Merve Gultekinoglu, Xinyue Jiang, Cem Bayram, Kezban Ulubayram, Mohan Edirisinghe
Amphiphilic block copolymers are widely used in science owing to their versatile properties. In this study, amphiphilic block copolymer poly(lactic-co-glycolic acid)-block-poly(ethylene glycol) (PLGA-b-PEG) was used to create micro droplets in a T-junction microfluidic device with a well-defined geometry. In order to compare interfacial characteristics of micro droplets, dichloromethane (DCM) and chloroform were used to prepare PLGA-b-PEG solution as an oil phase. In the T-junction device water and oil phases were manipulated at variable flow rates from 50 µL/min to 300 µL/min by increments of 50 µL/min...
May 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29772242/synthesis-molecular-modeling-and-biological-evaluation-of-potent-analogs-of-2-methoxyestradiol
#3
Nora Al-Kazaale, Phuong T Tran, Farhad Haidari, Eirik Johansson Solum, Sandra Liekens, Peter Vervaeke, Ingebrigt Sylte, Jing-Jy Cheng, Anders Vik, Trond Vidar Hansen
The endogenous steroid 2-methoxyestradiol (1) has attracted a great interest as a lead compound towards the development of new anti-cancer drugs. Herein, the synthesis, molecular modeling, anti-proliferative and anti-angiogenic effects of ten 2-ethyl and four 2-methoxy analogs of estradiol are reported. The ethyl group was introduced to the steroid A-ring using a novel Friedel-Crafts alkylation protocol. Several analogs displayed potent anti-proliferative activity with IC50 -values in the submicromolar range towards the CEM human leukemia cancer cell line...
May 14, 2018: Steroids
https://www.readbyqxmd.com/read/29764791/giant-cell-tumor-of-the-temporal-bone-and-skull-base-a-case-report
#4
İsa Kaya, Murat Benzer, Göksel Turhal, Gode Sercan, Cem Bilgen, Tayfun Kirazlı
Giant cell tumor (GCT) is a benign tumor that originates from undifferentiated mesenchymal cells of the bone marrow. The cranium as well as temporal bone is a rare location for GCTs. Despite its benign nature, GCT may be locally aggressive and has the potential to recur locally. Furthermore, GCT may give rise to pulmonary metastases (~1%) in addition to causing local bone destruction. Surgical excision is the treatment of choice for patients with GCT. We describe the case of a 56-year-old female who presented with headache and hearing loss with extensive GCT, which originated in the squamous part of the temporal bone and extended into the left mandibular fossa and middle ear...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29762510/three-new-cytotoxic-steroidal-alkaloids-from-sarcococca-hookeriana
#5
Kang He, Jinxi Wang, Juan Zou, Jichun Wu, Shaojie Huo, Jiang Du
Three new steroidal alkaloids with an unusual 3 α tigloylamide group, named sarchookloides A⁻C ( 1 ⁻ 3 ), were isolated along with four known compounds ( 4 ⁻ 7 ) from the roots of Sarcococca hookeriana . Their structures and relative configuration were elucidated on the basis of spectroscopic methods including MS, UV, IR, 1D, and 2D NMR data. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines: Hela, A549, MCF-7, SW480, and CEM in vitro. All three amide substituted steroidal alkaloids exhibited significant cytotoxic activities with IC50 values of 1...
May 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29759593/electrodialytic-2-compartment-cells-for-emerging-organic-contaminants-removal-from-effluent
#6
Ana Rita Ferreira, Nazaré Couto, Paula Guedes, Joana Pinto, Eduardo P Mateus, Alexandra B Ribeiro
The present work discusses the efficiency of the electrodialytic (ED) process to remove emerging organic contaminants (EOCs) from effluent. The ED process was carried out in a cell of two-compartments (2 C-cell) with effluent in either the anode or cathode compartment, separated from the electrolyte compartment through an anion or a cation exchange membrane (AEM and CEM, respectively). As effluent destination might be soil irrigation, and having in mind the nutrient recycling, phosphorus was also monitored in the process...
April 27, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29757575/prognostic-role-of-preoperative-albumin-to-globulin-ratio-in-predicting-survival-of-clear-cell-renal-cell-carcinoma
#7
Murat Yavuz Koparal, Fazli Polat, Serhat Çetin, Ender Cem Bulut, Tevfik Sinan Sözen
PURPOSE: To investigate the prognostic role of preoperative albumin/globulin ratio (AGR) in predicting disease-free survival (DFS) and overall survival (OS) in localized and locally advanced clear cell renal cell carcinoma (RCC) patients. PATIENTS AND METHODS: 162 patients who met the criteria specified were included in the study. The DFS and OS ratios were determined using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were performed to determine the prognostic factors affecting DFS and OS...
May 5, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29757451/effects-of-zinc-oxide-on-mrna-expression-of-genes-in-brain-tissue-of-rats
#8
İnan Gezgin, Cem Öziç
AIM: Zinc oxide nanoparticles are flexible platforms for biotechnology and biomedical applications. To investigate the expression level of the DR4, DR5, OPG, DcR1 and DcR2 in brain tissue. MATERIAL AND METHODS: The expression of DR4, DR5, OPG, DcR1, DcR2 and β-actin were measured through RT-PCR and western blotting in brain tissues of all three groups. The mRNA expression levels of DR4, DR5, OPG, DcR1 and DcR2 was investigated by using the RT-PCR and western blotting methods...
April 24, 2018: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29750232/in-vitro-evaluation-of-bond-strength-of-four-self-etching-cements
#9
Julio Chávez-Lozada, Carmen Urquía-Morales
Indirect restorations need to be attached with adhesive luting agents to prevent them from becoming dislodged and provide adequate marginal sealing. The aim of this study was to evaluate bond strength to dentin of self-etching resin cements. MATERIALS AND METHODS: 75 flat dentin surfaces were randomly distributed among 5 groups, according to cements used; Group 1: RelyxU100 (3M/ESPE), Group 2: Bis Cem (Bisco), Group 3: Max Cem (Kerr), Group 4: SeT PP (SDI) and Group 5: Relyx ARC (3M/ESPE), control...
December 2017: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/29749488/c%C3%A2-myc-inhibitor-10058%C3%A2-f4-increases-the-efficacy-of-dexamethasone-on-acute-lymphoblastic-leukaemia-cells
#10
Mei Lv, Yi Wang, Wenmiao Wu, Shujun Yang, Huiling Zhu, Bei Hu, Ying Chen, Cong Shi, Yi Zhang, Qitian Mu, Guifang Ouyang
The long‑term survival rate in paediatric acute lymphoblastic leukaemia (ALL) exceeds 80%; however, the outcome of adult ALL remains to be poor. Glucocorticoids (GCs) are the preferred drugs in the traditional treatment of ALL patients. In the anti‑leukaemia molecular mechanisms of GCs, c‑Myc inhibition serves a critical role. In the present study, a c‑Myc inhibitor that increased the sensitivity to GCs in NALM6 cells of the B‑cell‑ALL cell line and CEM cells of the T‑cell‑ALL cell line was investigated...
April 27, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29748210/novel-fluoroindenoisoquinoline-non-camptothecin-topoisomerase-i-inhibitors
#11
Laetitia Marzi, Keli Agama, Junko Murai, Simone Difilippantonio, Amy James, Cody J Peer, William D Figg, Daniel Beck, Mohamed S A Elsayed, Mark Cushman, Yves Pommier
Contrary to other anticancer targets, topoisomerase I (TOP1) is targeted by only one chemical class of FDA-approved drugs: topotecan and irinotecan, the derivatives of the plant alkaloid, camptothecin. The indenoisoquinolines LMP400, LMP744 and LMP776 are novel non-camptothecin TOP1 inhibitors in clinical trial, which overcome the limitations of camptothecins. To further improve metabolic stability, their methoxy groups have been replaced by a fluorine, as in the fluoroindenoisoquinolines NSC 781517 (LMP517), NSC 779135 (LMP135) and NSC 779134 (LMP134)...
May 10, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29747757/a-naturally-occuring-triterpene-saponin-ardisiacrispin-b-displayed-cytotoxic-effects-in-multi-factorial-drug-resistant-cancer-cells-via-ferroptotic-and-apoptotic-cell-death
#12
Armelle T Mbaveng, Blanche L Ndontsa, Victor Kuete, Yves M M Nguekeu, İlhami Çelik, Roukayatou Mbouangouere, Pierre Tane, Thomas Efferth
INTRODUCTION: Multidrug resistance of cancer cells constitutes a serious problem in chemotherapy and a challenging issue in the discovery of new cytotoxic drugs. Many saponins are known to display anti-cancer effects. In this study, the cytotoxicity and the modes of action of a naturally occuring oleanane-type tritepene saponin, ardisiacrispin B isolated from the fruit of Ardisia kivuensis Taton (Myrsinaceae) was evaluated on a panel of 9 cancer cell lines including various sensitive and drug-resistant phenotypes...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29747552/the-estimation-of-bone-cyst-volume-using-the-cavalieri-principle-on-computed-tomography-images
#13
Ferhat Say, Murat Gölpınar, Cem Yalın Kılınç, Bünyamin Şahin
PURPOSE: To evaluate the volume of bone cyst using the planimetry method of the Cavalieri principle. METHODS: A retrospective analysis was carried out on data from 25 computed tomography (CT) images of patients with bone cyst. The volume of the cysts was calculated by two independent observers using the planimetry method. The procedures were repeated 1 month later by each observer. RESULTS: The overall mean volume of the bone cyst was 29.25 ± 25...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29746601/aberrant-activity-of-nkl-homeobox-gene-nkx3-2-in-a-t-all-subset
#14
Stefan Nagel, Corinna Meyer, Maren Kaufmann, Margarete Zaborski, Roderick A F MacLeod, Hans G Drexler
T-cell acute lymphoblastic leukemia (T-ALL) is a hematopoietic malignancy originating from T-cell progenitors in which differentiation is blocked at early stages. Physiological expression of specific NKL homeobox genes obeys a hematopoietic NKL-code implicated in the process of lymphopoiesis while in differentiated T-cells these genes are silenced. We propose that this developmental expression pattern underlies the observation that NKL homeobox genes are the most ubiquitous group of transcription factors deregulated in T-ALL, including TLX1, TLX3, NKX2-5 and NKX3-1...
2018: PloS One
https://www.readbyqxmd.com/read/29739644/evaluation-of-choroid-plexus-with-fetal-magnetic-resonance-imaging-what-happens-in-ventriculomegaly
#15
Sila Ulus, Cem Turam, Deniz Mutlu, Ipek Inal Kaleli, Mert Kocak, Umit Aksoy Ozcan
OBJECTIVES: Diagnosis of ventriculomegaly (VM) and identification of choroid plexus (CP) can be challenging with fetal magnetic resonance imaging (MRI). Our aim is to create an adjunct method for supporting the diagnosis of VM by investigating the CP-ventricular wall separation distance in fetuses with and without VM (nV) with fetal MRI. METHODS: T2-weighted fetal MRIs of 154 fetuses were retrospectively evaluated. The CP separation was defined as the distance between the medial wall of the dependent ventricle and distal tip of the CP glomus...
May 5, 2018: Brain & Development
https://www.readbyqxmd.com/read/29739137/methylphenidate-induced-lip-and-tongue-biting
#16
Cem Gokcen, Mehmet Karadag, Ihsan Aksoy
Attention deficit hyperactivity disorder (ADHD) is a life-long neurodevelopmental disorder and treatment depends on pharmacotherapy because of its biological origin. Stimulant drugs are the most commonly used treatment for ADHD and they have various side effects. Herein, we report a case who bit off the tip of her tongue with Osmotic Release Oral System methylphenidate (OROS MPH) 36 mg/day, bit the tip of her lower lip with immediate release (IR) MPH 10 mg/day and lateral part of her tongue with IR MPH 20 mg/day...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29736423/stroke-epidemiology-in-karab%C3%A3-k-city-turkey-community-based-study
#17
Nilay Padir Şensöz, Ülkü Türk Börü, Cem Bölük, Adnan Bilgiç, Özgür Öztop Çakmak, Arda Duman, Mustafa Taşdemir
Introduction: Stroke has been projected to increase in developing countries like Turkey. Information about the prevalence of stroke may uncover the etiology of stroke and overcome its impact burden. However, data is limited due to a lack of studies based in Turkey and neighboring regions. We aimed to investigate the prevalence and risk factors of stroke in the Turkish city of Karabük and to pave the way for future epidemiological studies in Turkey. Methods: The study was designed as a cross-sectional, door-to-door survey...
March 2018: ENeurologicalSci
https://www.readbyqxmd.com/read/29736289/the-rare-togetherness-of-bladder-leiomyoma-and-neurofibromatosis
#18
Cem Yucel, Salih Budak, Erdem Kisa, Orcun Celik, Zafer Kozacioglu
Neurofibromatosis Type 1 (Von Recklinghausen disease) is a common, autosomal dominant hereditary disorder characterized by involvement of multiple tissues derived from the neural crest. Urinary system involvement in neurofibromatosis is a rare condition. Leiomyoma of the bladder is a rare benign mesenchymal tumor. In this case, our experience and approach regarding the bladder leiomyoma development in a patient diagnosed with neurofibromatosis are presented and the literature data has been reviewed.
2018: Case Reports in Urology
https://www.readbyqxmd.com/read/29733006/barriers-and-opportunities-related-to-extracorporeal-cardiopulmonary-resuscitation-for-out-of-hospital-cardiac-arrest-in-canada-a-report-from-the-first-meeting-of-the-canadian-ecpr-research-working-group
#19
Steven C Brooks, Sam D Shemie, Sylvia Torrance, Laura Hornby, Clay Gillrie, Brian Grunau, A Dave Nagpal, Andrew Baker, Jim Christenson, John Gill, Laurie Morrison
For a French translation of the executive summary, please see the Supplementary Material at DOI: 10.107/cem.2017.429.
May 7, 2018: CJEM
https://www.readbyqxmd.com/read/29732014/comparison-of-the-shear-bond-strength-of-silorane-based-composite-resin-and-methacrylate-based-composite-resin-to-mta
#20
Buse Ayse Serin, Muharrem Cem Dogan, Hamdi Oguz Yoldas
Background. Mineral trioxide aggregate (MTA) is a material that has recently gained popularity in the application of the vital pulp therapy. Along with the increasing use of MTA to this end, the permanent restoration material to be placed on MTA has become a significant issue. The aim of this in vitro study was to investigate the bond strength of the novel low-shrinkage silorane-based composite resin (SBC) to MTA. Methods. Twenty acrylic blocks filled with MTA were prepared for this study. SBC was the test group and methacrylate-based composite resin (MBC) was used as the control group...
2018: Journal of Dental Research, Dental Clinics, Dental Prospects
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