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https://www.readbyqxmd.com/read/28728577/integrating-data-from-randomized-controlled-trials-and-observational-studies-to-predict-the-response-to-pregabalin-in-patients-with-painful-diabetic-peripheral-neuropathy
#1
Joe Alexander, Roger A Edwards, Alberto Savoldelli, Luigi Manca, Roberto Grugni, Birol Emir, Ed Whalen, Stephen Watt, Marina Brodsky, Bruce Parsons
BACKGROUND: More patient-specific medical care is expected as more is learned about variations in patient responses to medical treatments. Analytical tools enable insights by linking treatment responses from different types of studies, such as randomized controlled trials (RCTs) and observational studies. Given the importance of evidence from both types of studies, our goal was to integrate these types of data into a single predictive platform to help predict response to pregabalin in individual patients with painful diabetic peripheral neuropathy (pDPN)...
July 20, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28725246/effects-of-vaginal-cylinder-position-on-dose-distribution-in-patients-with-endometrial-carcinoma-in-treatment-of-vaginal-cuff-brachytherapy
#2
Yurday Ozdemir, Yemliha Dolek, Cem Onal
PURPOSE: To investigate the impact of different cylinder positions on dosimetry of critical structures in patients with endometrial carcinoma undergoing three-dimensional image-based vaginal cuff brachytherapy (VCB). MATERIAL AND METHODS: We delivered VCB at a dose of 4 Gy to a depth of 5 mm in the vaginal cuff of 15 patients using three different cylinder positions (neutral [N], parallel [P], and angled [A]) according to the longitudinal axis of the patient. We analyzed the dose-volume distribution and volumetric variability of the rectum and bladder...
June 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28724217/chondroprotective-and-anti-nociceptive-effects-of-caffeoylquinic-acid-in-osteoarthritis-by-downregulating-catabolic-activity-and-oxidative-damage-in-chondrocytes
#3
Luping Liu, Yongmei Li
We evaluated the chondroprotective and anti-nociceptive effects of caffeoylquinic acid (CA) in a rat osteoarthritis (OA) model. Monosodium iodoacetate was injected intra-articularly in the rats to produce OA. The rats were divided into three groups: control, OA group, which received vehicle, and the CA-treated group, which received CA (50mg/kg, p.o.) for 14days. At the end of the protocol, pain was estimated by observing the paw withdrawal threshold and latency. Degeneration of cartilage was assessed through histomorphological and microscopical examination of joints...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28721295/different-treatment-approaches-after-failure-of-laparascopic-treatment-of-calyceal-diverticulum-confused-with-communicating-type-renal-cyst-case-report
#4
Ayhan Dirim, Eray Hasirci, Yuksel Cem Aygun Baskent
No abstract text is available yet for this article.
June 30, 2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28719601/clic-a-tool-for-expanding-biological-pathways-based-on-co-expression-across-thousands-of-datasets
#5
Yang Li, Alexis A Jourdain, Sarah E Calvo, Jun S Liu, Vamsi K Mootha
In recent years, there has been a huge rise in the number of publicly available transcriptional profiling datasets. These massive compendia comprise billions of measurements and provide a special opportunity to predict the function of unstudied genes based on co-expression to well-studied pathways. Such analyses can be very challenging, however, since biological pathways are modular and may exhibit co-expression only in specific contexts. To overcome these challenges we introduce CLIC, CLustering by Inferred Co-expression...
July 18, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28718586/-adverse-events-of-biologic-therapies
#6
Gregory Fleury, Cem Gabay
Biological therapies have revolutionized the management and the outcome of patients with inflammatory rheumatic diseases. The prescription and the number of patients under biotherapies have greatly increased. Unfortunately, these treatments are occasionally accompanied by side effects usually reversible upon treatment discontinuation. Some are preventable or can be reduced, including through the screening and prevention (tuberculosis screening, vaccination…). It is important to be aware of these different side effects to adapt the prescription of biologics according to the patient's profile (history of infection, malignancy, heart failure…)...
March 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28718585/complications-iatrog%C3%A3-nes-ce-que-tout-m%C3%A3-decin-doit-conna%C3%A3-tre
#7
EDITORIAL
Cem Gabay, Alexander So
No abstract text is available yet for this article.
March 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28718477/nhc-stabilized-1-hydrosilaimine-synthesis-structure-and-reactivity
#8
Debabrata Dhara, Thangavel Vijayakanth, Milan Kr Barman, Khevath Praveen Kumar Naik, Nicolas Chrysochos, Cem B Yildiz, Ramamoorthy Boomishankar, Carola Schulzke, Vadapalli Chandrasekhar, Anukul Jana
A facile, straightforward synthesis of N-heterocyclic carbene (NHC)-stabilized 1-hydrosilaimine starting from a silicon(iv)-precursor is reported. It has been employed for the addition of an O-H bond of water under ambient conditions without any additional catalyst.
July 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28716475/fouling-assemblage-of-benthic-plastic-debris-collected-from-mersin-bay-ne-levantine-coast-of-turkey
#9
Sedat Gündoğdu, Cem Çevik, Serkan Karaca
The Mediterranean is an ecosystem that faces more and more microplastic pollution every day. This causes the whole of the Mediterranean to face the negative effects of plastic pollution. This study examines the state of plastic debris and fouling organisms found on it in one of the areas most affected by plastic pollution, Mersin Bay. As a result, a total of 3.88kg plastic (mean=0,97kg; n=120; 2670item/km(2); 86,3kg/km(2)) was collected and based on the ATR-FTIR analysis, it was determined that this total contained 9 types of plastics...
July 14, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28715864/in-vitro-and-in-vivo-anticancer-activity-of-2-acetyl-benzylamine-isolated-from-adhatoda-vasica-l-leaves
#10
C Balachandran, Y Arun, B Sangeetha, V Duraipandiyan, S Awale, N Emi, S Ignacimuthu, P T Perumal
One of the important aims of drug discovery for cancer is to find therapeutic agents from natural products that are effective and safe for cancer treatment. In the current study, an alkaloid, 2-acetyl-benzylamine, isolated from Adhatoda vasica, was screened for potent anticancer properties against leukemia cells. We used seven different types of leukemia cells such as CEM, NB-4, MOLM-14, Jurkat, IM-9, K562 and HL-60 for cytotoxic studies. 2-acetyl-benzylamine showed significant cytotoxic properties against MOLM-14 and NB-4 cells with IC50 values of 0...
July 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28715802/nerve-glial-antigen-2-a-novel-target-for-anti-tumor-therapy-in-colorectal-cancer
#11
Cem Cengiz, Safak Bulut, A Sedat Boyacioglu, M Ayhan Kuzu
BACKGROUND/AIMS: To identify cell surface markers selectively expressed by tumor cells and tumor vasculature is the current goal for tumor therapy. One such marker is nerve/glial antigen 2 (NG2), which is a transmembrane glycoprotein. We aimed to investigate the expression of NG2 in colorectal cancer (CRC) and its association with clinicopathological parameters. METHODS: Immunohistochemical staining of NG2, vascular endothelial growth factor, and CD34 in 65 patients diagnosed with CRC over a 5-year period was performed...
July 18, 2017: Digestion
https://www.readbyqxmd.com/read/28707558/effect-of-unconjugated-hyperbilirubinemia-on-neonatal-autonomic-functions-evaluation-by-heart-rate-variability
#12
Rahmi Ozdemir, Ozgur Olukman, Cem Karadeniz, Kiymet Celik, Nagehan Katipoglu, Murat Muhtar Yilmazer, Sebnem Calkavur, Timur Mese, Sertac Arslanoglu
BACKGROUND: Beyond the physiological levels of bilirubin may leads to alterations in autonomic regulation. Heart rate variability (HRV), is a noninvasive and quantitative marker of the activity of the autonomic nervous system (ANS). To date, few studies have been evaluated the undesirable effects of severe unconjugated hyperbilirubinemia (UHB) on autonomic functions, and only one study has used HRV as a marker of the autonomic activity. However, the relationship between altered cardiac autonomic functions and UHB by using the HRV derived from 24-hour Holter electrocardiography (ECG) recording previously...
July 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28697193/the-value-of-18-fdg-pet-ct-parameters-hematological-parameters-and-tumor-markers-in-predicting-kras-oncogene-mutation-in-colorectal-cancer
#13
Ali Ozan Oner, Evrim Surer Budak, Senay Yıldırım, Funda Aydın, Cem Sezer
OBJECTIVE: In this study we investigated the predictive value of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), neutrophils/lymphocytes ratio (NLR), platelets/lymphocytes ratio (PLR), carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) in the prediction of KRAS gene mutation which plays an important role in the choice of treatment in colorectal cancer patients. SUBJECTS AND METHODS: A total of 55 cases with untreated colorectal cancer who had undergone both PET/CT examinations for initial staging and also mutation analysis of KRAS oncogene were studied...
July 12, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28694829/physical-trauma-among-refugees-comparison-between-refugees-and-local-population-who-were-admitted-to-emergency-department-experience-of-a-state-hospital-in-syrian-border-district
#14
Yigit Duzkoylu, Salim Ilksen Basceken, Emrullah Cem Kesilmez
BACKGROUND: Hundreds of thousands of people have fled to Turkey since the civil war started in Syria in 2011. Refugees and local residents have been facing various challenges such as sociocultural and economic ones and access to health services. Trauma exposure is one of the most important and underestimated health problems of refugees settling in camps. AIMS: We aimed to evaluate refugee admissions to emergency department because of trauma in means of demographics of patients and mechanism of trauma and compare the results with the local population...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28691138/the-importance-of-parameters-mpv-mpv-thrombocyte-ratio-and-neutrophil-lymphocyte-ratio-in-sorafenib-treatment-response-of-patients-with-hepatocellular-cancer
#15
Ali Oğul, Berksoy Şahin, Ferit Kuşçu, Onur Taktakoğlu, Abdullah Evren Yetişir, Mahmut Büyükşimşek, Cem Mirili, Serkan Gökçay, M Gökhan Gök, Pınar Kum
No abstract text is available yet for this article.
July 10, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28690339/the-tenure-gap-in-electoral-participation-instrumental-motivation-or-selection-bias-comparing-homeowners-and-tenants-across-four-housing-regimes
#16
Stéfanie André, Caroline Dewilde, Ruud Luijkx
Integrating housing tenure in Instrumental Motivation Theory predicts a tenure gap in electoral participation, as homeowners would be more motivated to vote compared with tenants. The empirical question is whether this effect is causal or rather due to selection into different housing tenures. This question is tackled using coarsened exact matching (CEM) on data for 19 countries, allowing us to better control for endogeneity. Even then, homeowners are found to vote more often than tenants. This association is stronger in countries characterized by a strong pro-homeownership ideology and/or where the financialization of housing markets turned houses into assets...
June 2017: International Journal of Comparative Sociology
https://www.readbyqxmd.com/read/28688886/antileukemic-ancistrobenomine-b-and-related-5-1-coupled-naphthylisoquinoline-alkaloids-from-the-chinese-liana-ancistrocladus-tectorius
#17
Gerhard Bringmann, Raina Seupel, Doris Feineis, Minjuan Xu, Guoliang Zhang, Marcel Kaiser, Reto Brun, Ean-Jeong Seo, Thomas Efferth
A striking feature of the metabolite pattern of the Southeast Asian liana Ancistrocladus tectorius (Ancistrocladaceae) is the predominance of 5,1'-coupled naphthylisoquinoline alkaloids. About 20 alkaloids of this coupling type have so far been discovered in this plant species. Here, we report on the isolation of four new 5,1'-linked naphthylisoquinolines from the twigs and stems of A. tectorius. Two of them, the ancistrobenomines B (5) and C (6), belong to the very rare group of alkaloids with a fully dehydrogenated isoquinoline portion...
July 6, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28686618/network-effects-in-environmental-justice-struggles-an-investigation-of-conflicts-between-mining-companies-and-civil-society-organizations-from-a-network-perspective
#18
Cem Iskender Aydin, Begum Ozkaynak, Beatriz Rodríguez-Labajos, Taylan Yenilmez
This paper examines conflicts that occur between mining companies and civil society organizations (CSOs) around the world and offers an innovative analysis of mining conflicts from a social network perspective. The analysis showed that, as the number of CSOs involved in a conflict increased, its outcome was more likely to be perceived as a success in terms of environmental justice (EJ); if a CSO was connected to other central CSOs, the average perception of EJ success was likely to increase; and as network distance between two conflicts increased (or decreased), they were more likely to lead to different (or similar) EJ outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28685086/outcomes-of-aggressive-treatment-in-esophageal-cancer-patients-with-synchronous-solitary-brain-metastasis
#19
Cem Onal, Berna Akkus Yildirim, Ozan Cem Guler
The aim of the present study was to investigate the outcomes of esophageal cancer (EC) patients with isolated synchronous brain oligometastasis (oligo-BM) treated with chemoradiotherapy (CRT) of the primary site and localized treatment of the BM with surgery, radiotherapy (RT) or radiosurgery. Of 125 EC patients investigated, seven patients (6%) had solitary BM. Six patients were diagnosed prior to, and one patient was diagnosed during, treatment. All patients were treated with neoadjuvant chemotherapy and whole-brain RT (WBRT) for BM...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28675984/vitd3-loaded-solid-lipid-nanoparticles-stability-cytotoxicity-and-cytokine-levels
#20
Murat Demirbilek, Nelisa Laçin Türkoglu, Selçuk Aktürk, Cem Akça
Vitamin D3 (VitD3) has several beneficial effects on many metabolic pathways such as immunity system, bone development. The aim of the study, encapsulation of VitD3 with solid lipids, determine encapsulation efficiency and biocompatibility of nanoparticles. Therefore, VitD3-loaded solid lipid nanoparticles (SLNPs) were developed by optimising ratios of VitD3, stearic acid, beeswax and sodium dodecyl sulphate (SDS). Thermal stability, degradation profile, crystallinity rate, encapsulation efficiency and release profile of SLNPs were determined...
July 4, 2017: Journal of Microencapsulation
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