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https://www.readbyqxmd.com/read/28432016/inkjet-printing-of-antiviral-pcl-nanoparticles-and-anticancer-cyclodextrin-inclusion-complexes-on-bioadhesive-film-for-cervical-administration
#1
Cem Varan, Henrika Wickström, Niklas Sandler, Yeşim Aktaş, Erem Bilensoy
Personalized medicine is an important treatment approach for diseases like cancer with high intrasubject variability. In this framework, printing is one of the most promising methods since it permits dose and geometry adjustment of the final product. With this study, a combination product consisting of anticancer (paclitaxel) and antiviral (cidofovir) drugs was manufactured by inkjet printing onto adhesive film for local treatment of cervical cancers as a result of HPV infection. Furthermore, solubility problem of paclitaxel was overcome by maintaining this poorly soluble drug in a cyclodextrin inclusion complex and release of cidofovir was controlled by encapsulation in polycaprolactone nanoparticles...
April 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28430113/should-physicians-instead-of-industry-representatives-be-the-main-actor-of-cardiac-implantable-electronic-device-follow-up-super-follow-up
#2
Çağın Mustafa Üreyen, Cem Yunus Baş, İsa Öner Yüksel, Görkem Kuş, Göksel Çağırcı, Şakir Arslan
OBJECTIVE: This retrospective study sought to research the adequacy of the follow-up and optimization of cardiac implantable electronic devices (CIEDs) performed by industry representatives. METHODS: A total of 403 consecutive patients (35% females; median age, 67 years; age range 18-97 years) with either pacemakers (n=246), implantable cardioverter-defibrillators (ICDs), (n=117) or cardiac resynchronization therapy with defibrillator (CRT-D) (n=40) applied to our hospital's outpatient pacemaker clinic for follow-up...
April 19, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28429926/the-efficacy-of-intraurethral-lidocaine-in-optical-internal-urethrotomy-for-anterior-urethral-stricture-a-multicenter-study
#3
Nedim Y Cem, Yıldız Yildiray, Cem Ö Berat, Melih S Mehmet, Gökhan D Ömer, Metin H Ahmet, Özyuvalı Ekrem, Ayyıldız Ali
BACKGROUND: Male anterior urethral strictures can be treated successfully with the help of optical internal urethrotomy (OIU) and is usually performed under general or regional anaesthesia. In this study, we determined the efficacy of intraurethral lidocaine in OIU for anterior urethral stricture in an outpatient setting. METHODS: 157 patients with anterior urethral strictures underwent OIU under local urethral anaesthesia with lidocaine. Optical urethrotomy was performed with a cold-cutting knife...
April 20, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28424890/left-atrial-electromechanical-conduction-time-predicts-atrial-fibrillation-in-patients-with-mitral-stenosis-a-5-year-follow-up-speckle-tracking-echocardiography-study
#4
Ozkan Candan, Cetin Gecmen, Arzu Kalayci, Cem Dogan, Emrah Bayam, Mehmet Ozkan
Prolonged left atrial electromechanical conduction time is related with atrial electrical remodeling, and is predictive of the development of atrial fibrillation. The aim of our study was to examine whether left atrial electromechanical conduction time (EMT) and left atrial strain as measured by speckle tracking echocardiography (STE) are predictors for the development of atrial fibrillation (AF) in patients with mitral stenosis (MS) at 5-year follow-up. A total of 81 patients (61% females; mean age 38.1 ± 12...
April 19, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28424435/-euroaspire-iv-european-society-of-cardiology-study-of-lifestyle-risk-factors-and-treatment-approaches-in-patients-with-coronary-artery-disease-data-from-turkey
#5
Lale Tokgözoğlu, Meral Kayıkçıoğlu, Servet Altay, Sinan Aydoğdu, Cem Barçın, Cem Bostan, Hüseyin Altuğ Çakmak, Alp Burak Çatakoğlu, Samim Emet, Oktay Ergene, Ali Kemal Kalkan, Barış Kaya, Cansın Tulunay Kaya, Cihangir Kaymaz, Nevrez Koylan, Hakan Kültürsay, Aytekin Oğuz, Ebru Özpelit, Serkan Ünlü
OBJECTIVE: Data from EUROASPIRE-IV Turkey report investigating risk factors and adherence to guidelines in patients hospitalized for coronary artery disease are presented and results are compared with those of EUROASPIRE-III Turkey and EUROASPIRE-IV Europe. METHODS: Study was performed in 24 European countries, including Turkey (17 centers). Patients (18-80 years old) hospitalized for coronary (index) event during preceding 3 years were identified from hospital records and interviewed ≥6 months later...
March 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28422836/fecal-microbiota-transplantation-is-a-rescue-treatment-modality-for-refractory-ulcerative-colitis
#6
Ahmet Uygun, Kadir Ozturk, Hakan Demirci, Cem Oger, Ismail Yasar Avci, Turker Turker, Mustafa Gulsen
BACKGROUND: Fecal microbial transplantation (FMT) provides to replace beneficial bacteria with more favorable microbiomes in recipient with dysbiosis. The aim of the present study was to prospectively investigate the efficacy of FMT by assessing the clinical and endoscopic response in patients with ulcerative colitis (UC) who had failed anti-inflammatory and immunosuppressive therapy. METHODS: In this prospective and uncontrolled study, 30 patients with UC were included...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28419928/design-synthesis-and-biological-evaluation-of-3-substituted-2-oxindole-hybrid-derivatives-as-novel-anticancer-agents
#7
Romeo Romagnoli, Pier Giovanni Baraldi, Filippo Prencipe, Paola Oliva, Stefania Baraldi, Maria Kimatrai Salvador, Luisa Carlota Lopez-Cara, Roberta Bortolozzi, Elena Mattiuzzo, Giuseppe Basso, Giampietro Viola
The 2-oxindole nucleus is the central core to develop new anticancer agents and its substitution at the 3-position can effect antitumor activity. Utilizing a pharmacophore hybridization approach, a novel series of antiproliferative agents was obtained by the modification of the structure of 3-substituted-2-oxindole pharmacophore by the attachment of the α-bromoacryloyl moiety, acting as a Michael acceptor, at the 5-position of 2-oxindole framework. The impact of the substituent at the 3-position of 2-oxindole core on the potency and selectivity against a panel of seven different cancer cell lines was examined...
April 13, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28418653/synthesis-and-biological-evaluation-of-the-first-triple-inhibitors-of-human-topoisomerase-1-tyrosyl-dna-phosphodiesterase-1-tdp1-and-tyrosyl-dna-phosphodiesterase-2-tdp2
#8
Ping Wang, Mohamed S A Elsayed, Caroline B Plescia, Azhar Ravji, Christophe E Redon, Evgeny Kiselev, Christophe Marchand, Olga Zeleznik, Keli Agama, Yves Pommier, Mark Cushman
Tdp1 and Tdp2 are two tyrosyl-DNA phosphodiesterases that can repair damaged DNA resulting from topoisomerase inhibitors and a variety of other DNA-damaging agents. Both Tdp1 and Tdp2 inhibition could hypothetically potentiate the cytotoxicities of topoisomerase inhibitors. This study reports the successful structure-based design and synthesis of new 7-azaindenoisoquinolines that act as triple inhibitors of Top1, Tdp1, and Tdp2. Enzyme inhibitory data and cytotoxicity data from human cancer cell cultures establish that modification of the lactam side chain of the 7-azaindenoisoquinolines can modulate their inhibitory potencies and selectivities vs Top1, Tdp1, and Tdp2...
April 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28418343/the-use-of-human-epididymis-4-and-cancer-antigen-125-tumor-markers-in-the-benign-or-malignant-differential-diagnosis-of-pelvic-or-adnexal-masses
#9
Zehra Nihal Dolgun, Canan Kabaca, Ateş Karateke, Cem İyibozkurt, Cihan İnan, Ahmet Salih Altıntaş, Cihan Karadağ
BACKGROUND: Ovarian cancer is one of the highest mortality cancers in gynaecology. Discrimination of benign masses from malignant ones may sometimes become a challenge for the clinician since there is not a reliable tumour marker, thus some unnecessary, highly morbid operations can be performed. AIMS: To explore the efficacy of human epididymis 4 (HE 4) and cancer antigen 125 (CA 125) markers in differentiating malignant and benign pelvic masses of ovarian origin and to identify the cut-off points for those markers...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28416928/comparison-of-anesthetic-administration-according-to-method-of-hip-surgery
#10
Aysin Ersoy Esenyel, Cem Zeki Esenyel, Zekeriya Ervatan, Nuri Yakar, Mensure Cakirgoz, Ismail Kalkar, Metin Seyran
OBJECTIVE: The aim of this study is to compare total hip prosthesis (THP), partial hip prosthesis (PHP), and proximal femoral nail (PFN) patients in terms of the chosen anesthetic method. METHODS: A total of 850 patients who underwent hip surgery were divided into 3 groups according to the operation type: PHP (n=281), PFN (n=393), and THP (n=176). The type of anesthesia administered, interventions during anesthesia, and complications were retrospectively evaluated...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28416010/the-effect-of-thymoquinone-coating-on-adhesive-properties-of-polypropylene-mesh
#11
Oktay Aydin, Kuzey Aydinuraz, Fatih Agalar, I Tayfun Sahiner, Canan Agalar, Cem Bayram, Emir Baki Denkbas, Pinar Atasoy
BACKGROUND: An incisional hernia is a common complication following abdominal surgery. Polypropylene mesh is frequently used in the repair of such defects and has nearly become the standard surgical treatment modality. Though they are very effective in reducing recurrence, mesh materials exhibit a strong stimulating effect for intraabdominal adhesion. The thymoquinone (TQ) extracted from Nigella sativa seeds has potential medical properties. TQ has anti-inflammatory, antioxidant and antibacterial properties...
April 17, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28414275/a-new-hypothesis-on-the-frequency-discrimination-of-the-cochlea
#12
Erdoğan Bulut, Cem Uzun, Levent Öztürk, Pınar Turan, Mehmet Kanter, Serap Arbak
OBJECTIVE: Medial olivocochlear efferent (MOCE) neurons innervate outer hair cells (OHCs) of the cochlea, which in turn leads to basilar membrane motion. We hypothesized that MOCE-induced alterations in basilar membrane motion, independent of traveling waves, is responsible for the cochlear frequency discrimination of sound. MATERIALS AND METHODS: Eleven guinea pigs underwent bilateral otoscopic and audiologic evaluations under general anesthesia. The study comprised two parts...
April 17, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28412052/-the-relationship-between-preoperative-anxiety-levels-and-vasovagal-incidents-during-the-administration-of-spinal-anesthesia
#13
Mürsel Ekinci, Birzat Emre Gölboyu, Onur Dülgeroğlu, Murat Aksun, Pınar Karaca Baysal, Erkan Cem Çelik, Ayşe Nur Yeksan
BACKGROUND: It was aimed to investigate the relationship between preoperative anxiety and vasovagal symptoms observed during the administration of spinal anesthesia in patients undergoing surgery in the perianal and inguinal regions. METHODS: The study included patients with planned surgery for inguinal hernia repair, anal fissure, hemorrhoid and pilonidal sinus excision. The study included a total of 210 patients of ASA I-II, aged 18-65 years. Patients were evaluated in respect of demographic characteristics, smoking and alcohol consumption, ASA grade and educational level...
April 12, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28411575/the-risk-factors-of-possible-ptsd-in-individuals-exposed-to-a-suicide-attack-in-turkey
#14
Altan Eşsizoğlu, Ali Ercan Altınöz, Harun Olcay Sonkurt, Murat Can Kaya, Ferdi Köşger, Cem Kaptanoğlu
The aims of this study were to determine both the rate of possible PTSD in individuals who were exposed to a suicide attack in Ankara, Turkey, and the factors that relate to the elevated risk for PTSD in individuals who survived that suicide attack. The researchers carried out the study with 93 participants who had attended a meeting held in Ankara on October 10, 2015. Participants completed a sociodemographic information form, the Traumatic Stress Symptom Checklist (TSSC), the Post-Traumatic Cognitions Inventory, the Beck Depression Inventory (BDI), and the Influence of Perceived Societal Attitudes Questionnaire (IPSAQ)...
April 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28411274/posterior-orbitofrontal-and-anterior-cingulate-pathways-to-the-amygdala-target-inhibitory-and-excitatory-systems-with-opposite-functions
#15
Basilis Zikopoulos, Malin Hoistad, Yohan John, Helen Barbas
The bidirectional dialogue of the primate posterior orbitofrontal cortex (pOFC) with the amygdala is essential in cognitive-emotional functions. The pOFC also sends a uniquely one-way excitatory pathway to the amygdalar inhibitory intercalated masses (IM), which inhibit the medial part of the central amygdalar nucleus (CeM). Inhibition of IM has the opposite effect, allowing amygdalar activation of autonomic structures and emotional arousal. Using multiple labeling approaches to identify pathways and their postsynaptic sites in the amygdala in rhesus monkeys we found that the anterior cingulate cortex (ACC) innervated mostly the basolateral and CeM amygdalar nuclei, poised to activate CeM for autonomic arousal...
April 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28409246/the-impact-of-androgen-deprivation-therapy-on-setup-errors-during-external-beam-radiation-therapy-for-prostate-cancer
#16
Cem Onal, Yemliha Dolek, Yurday Ozdemir
PURPOSE: To determine whether setup errors during external beam radiation therapy (RT) for prostate cancer are influenced by the combination of androgen deprivation treatment (ADT) and RT. MATERIALS AND METHODS: Data from 175 patients treated for prostate cancer were retrospectively analyzed. Treatment was as follows: concurrent ADT plus RT, 33 patients (19%); neoadjuvant and concurrent ADT plus RT, 91 patients (52%); RT only, 51 patients (29%). Required couch shifts without rotations were recorded for each megavoltage (MV) cone beam computed tomography (CBCT) scan, and corresponding alignment shifts were recorded as left-right (x), superior-inferior (y), and anterior-posterior (z)...
April 13, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28408400/epigenetic-identity-in-aml-depends-on-disruption-of-non-promoter-regulatory-elements-and-is-affected-by-antagonistic-effects-of-mutations-in-epigenetic-modifiers
#17
Jacob Glass, Duane C Hassane, Bas Wouters, Hiroyoshi Kunimoto, Roberto Avellino, Francine E Garrett-Bakelman, Olga A Guryanova, Robert Bowman, Shira Redlich, Andrew Intlekofer, Cem Meydan, Tingting Qin, Mame P Fall, Alicia Alonso, Monica L Guzman, Peter Jm Valk, Craig B Thompson, Ross L Levine, Olivier Elemento, Ruud Delwel, Ari Melnick, Maria E Figueroa
Aberrant DNA methylation of gene promoters is a hallmark of AML. To define more precisely how cytosine methylation is redistributed in AML, we performed base-pair resolution methylome sequencing in 119 patients. We find that leukemic DNA methylation patterning is tightly linked to somatic mutations and primarily driven by regulatory elements outside of promoters and by CpG shores as opposed to CpG islands. Active enhancers displayed much stronger focal differential methylation than promoters and were generally aberrantly hypomethylated except in IDH2 mutant and CEBPA silenced AMLs...
April 13, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28405618/efficacy-of-alk5-inhibition-in-myelofibrosis
#18
Lanzhu Yue, Matthias Bartenstein, Wanke Zhao, Wanting Tina Ho, Ying Han, Cem Murdun, Adam W Mailloux, Ling Zhang, Xuefeng Wang, Anjali Budhathoki, Kith Pradhan, Franck Rapaport, Huaquan Wang, Zonghong Shao, Xiubao Ren, Ulrich Steidl, Ross L Levine, Zhizhuang Joe Zhao, Amit Verma, Pearlie K Epling-Burnette
Myelofibrosis (MF) is a bone marrow disorder characterized by clonal myeloproliferation, aberrant cytokine production, extramedullary hematopoiesis, and bone marrow fibrosis. Although somatic mutations in JAK2, MPL, and CALR have been identified in the pathogenesis of these diseases, inhibitors of the Jak2 pathway have not demonstrated efficacy in ameliorating MF in patients. TGF-β family members are profibrotic cytokines and we observed significant TGF-β1 isoform overexpression in a large cohort of primary MF patient samples...
April 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28401855/brugada-syndrome-and-calcium-channel-mutation-in-a-patient-with-congenital-deaf-mutism
#19
Uğur Canpolat, Cem Coteli, Kudret Aytemir
To the best of our knowledge, for the first time in the literature, we described a congenitally deaf-mute patient with Brugada syndrome (BrS) in whom a mutation in L-type Ca(+2) channel [CACNA1C (Cav1.2α1)] was identified.
January 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/28399943/bipolar-disorder-patients-display-reduced-serum-complement-levels-and-elevated-peripheral-blood-complement-expression-levels
#20
Uğur Akcan, Sercan Karabulut, Cem İsmail Küçükali, Sibel Çakır, Erdem Tüzün
OBJECTIVE: Bipolar disorder (BD) patients have recently been shown to exhibit increased proinflammatory cytokine levels indicating the role of inflammation in this disease. As inflammatory responses often include complement level alterations and complement production is influenced by cytokines, we aimed to find out whether complement system is activated in BD in a time-dependent manner and complement factors are involved in BD pathogenesis. METHODS: Serum C4, factor B, sC5b-9 and neuron-specific enolase levels were measured by enzyme-linked immunosorbent assay, whereas peripheral blood mononuclear cell messenger RNA (mRNA) expression levels of C1q, C4, factor B and CD55 were measured by real-time polymerase chain reaction in chronic BD patients (n=22), first episode BD patients (n=24) and healthy controls (n=19)...
April 12, 2017: Acta Neuropsychiatrica
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