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Medical logic module

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https://www.readbyqxmd.com/read/29908358/from-lexical-regularities-to-axiomatic-patterns-for-the-quality-assurance-of-biomedical-terminologies-and-ontologies
#1
Philip van Damme, Manuel Quesada-Martínez, Ronald Cornet, Jesualdo Tomás Fernández-Breis
Ontologies and terminologies have been identified as key resources for the achievement of semantic interoperability in biomedical domains. The development of ontologies is performed as a joint work by domain experts and knowledge engineers. The maintenance and auditing of these resources is also the responsibility of such experts, and this is usually a time-consuming, mostly manual task. Manual auditing is impractical and ineffective for most biomedical ontologies, especially for larger ones. An example is SNOMED CT, a key resource in many countries for codifying medical information...
June 13, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29775771/a-detailed-analysis-of-the-arden-syntax-expression-grammar
#2
Stefan Kraus, Marc Rosenbauer, Lutz Schröder, Thomas Bürkle, Klaus-Peter Adlassnig, Dennis Toddenroth
OBJECTIVE: The Arden Syntax for Medical Logic Systems is a standard for encoding and sharing medical knowledge in the form of Medical Logic Modules. To improve accessibility for clinicians, the originators of the standard deliberately designed Arden Syntax expressions to resemble natural language, and parentheses around operands are not generally required. For certain patterns of nested expressions, however, the use of parentheses is mandatory, otherwise they are not accepted by an Arden Syntax environment...
May 15, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29726456/achieving-interoperability-between-arden-syntax-based-clinical-decision-support-and-openehr-based-data-systems
#3
Martin Spineth, Andrea Rappelsberger, Klaus-Peter Adlassnig
BACKGROUND: Arden Syntax is an international standard for medical knowledge representation and processing. The openEHR Foundation publishes specifications for the creation of electronic health records based on interoperable data models. OBJECTIVES: To perform a feasibility study showing how Arden Syntax medical logic modules (MLMs) can access openEHR data. METHODS: Medexter's ArdenSuite was applied as an implementation of an Arden-Syntax-based clinical decision support framework, and Marand's EhrScape as an implementation of an openEHR system, for the purpose of data exchange...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29696548/semantic-enhanced-query-expansion-system-for-retrieving-medical-image-notes
#4
Yiqing Zhao, Nooshin J Fesharaki, Xiaohui Li, Timothy B Patrick, Jake Luo
Most current image retrieval methods require constructing semantic metadata for representing image content. To manually create semantic metadata for medical images is time-consuming, yet it is a crucial component for query expansion. We proposed a new method for searching medical image notes that uses semantic metadata to improve query expansion and leverages a knowledge model developed specifically for the medical image domain to create relevant metadata. We used a syntactic parser and the Unified Medical Language System to analyze the corpus and store text information as semantic metadata in a knowledge model...
April 25, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29678046/generalizing-the-arden-syntax-to-a-common-clinical-application-language
#5
Stefan Kraus
The Arden Syntax for Medical Logic Systems is a standard for encoding and sharing knowledge in the form of Medical Logic Modules (MLMs). Although the Arden Syntax has been designed to meet the requirements of data-driven clinical event monitoring, multiple studies suggest that its language constructs may be suitable for use outside the intended application area and even as a common clinical application language. Such a broader context, however, requires to reconsider some language features. The purpose of this paper is to outline the related modifications on the basis of a generalized Arden Syntax version...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28874934/emergency-physician-performed-transesophageal-echocardiography-in-simulated-cardiac-arrest
#6
MULTICENTER STUDY
Don V Byars, Jordan Tozer, John M Joyce, Michael J Vitto, Lindsay Taylor, Turan Kayagil, Matt Jones, Matthew Bishop, Barry Knapp, David Evans
INTRODUCTION: Transesophageal echocardiography (TEE) is a well-established method of evaluating cardiac pathology. It has many advantages over transthoracic echocardiography (TTE), including the ability to image the heart during active cardiopulmonary resuscitation. This prospective simulation study aims to evaluate the ability of emergency medicine (EM) residents to learn TEE image acquisition techniques and demonstrate those techniques to identify common pathologic causes of cardiac arrest...
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28859829/multi-model-based-interactive-authoring-environment-for-creating-shareable-medical-knowledge
#7
Taqdir Ali, Maqbool Hussain, Wajahat Ali Khan, Muhammad Afzal, Jamil Hussain, Rahman Ali, Waseem Hassan, Arif Jamshed, Byeong Ho Kang, Sungyoung Lee
OBJECTIVE: Technologically integrated healthcare environments can be realized if physicians are encouraged to use smart systems for the creation and sharing of knowledge used in clinical decision support systems (CDSS). While CDSSs are heading toward smart environments, they lack support for abstraction of technology-oriented knowledge from physicians. Therefore, abstraction in the form of a user-friendly and flexible authoring environment is required in order for physicians to create shareable and interoperable knowledge for CDSS workflows...
October 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28480231/an-interprofessional-curriculum-on-antimicrobial-stewardship-improves-knowledge-and-attitudes-toward-appropriate-antimicrobial-use-and-collaboration
#8
Conan MacDougall, Brian S Schwartz, Lisa Kim, Mari Nanamori, Sharmin Shekarchian, Peter V Chin-Hong
BACKGROUND: Inappropriate antimicrobial use can threaten patient safety and is the focus of collaborative physician and pharmacist antimicrobial stewardship teams. However, antimicrobial stewardship is not comprehensively taught in medical or pharmacy school curricula. Addressing this deficiency can teach an important concept as well as model interprofessional healthcare. METHODS: We created an antimicrobial stewardship curriculum consisting of an online learning module and workshop session that combined medical and pharmacy students, with faculty from both professions...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28366671/duodenal-long-noncoding-rnas-are-associated-with-glycemic-control-after-bariatric-surgery-in-high-fat-diet-induced-diabetic-mice
#9
Yongjun Liang, Bo Yu, Yueqian Wang, Zhengdong Qiao, Ting Cao, Peng Zhang
BACKGROUND: The duodenum plays a role in the mechanism of type 2 diabetes remission after bariatric surgery. Roux-en-Y gastric bypass (RYGB) may change gene expression in the duodenum and metabolism. Long noncoding RNAs (lncRNAs) constitute a novel class of RNAs that regulate gene expression. Little is known about how duodenal lncRNAs respond to RYGB. Logically, studies on the changes of duodenal lncRNAs potentially can lead to an understanding of the mechanisms of bariatric surgery, as well as discovery of antidiabetic drug targets and biomarkers predicting postoperative outcome...
July 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28283249/sphingosine-1-phosphate-signaling-in-inflammatory-bowel-disease
#10
REVIEW
Ole Haagen Nielsen, Yuan Li, Bengt Johansson-Lindbom, Mehmet Coskun
An unmet medical need exists for the development of targeted therapies for the treatment of inflammatory bowel disease (IBD) with easily administered and stable oral drugs, particularly as most patients on biologics [i.e., tumor necrosis factor (TNF) inhibitors and anti-integrins] are either primary non-responders or lose responsiveness during maintenance treatment. A new class of small molecules, sphingosine-1-phosphate (S1P) receptor modulators, has recently shown efficacy in IBD. Here we provide an overview of the mechanism of action of this novel treatment principle in the context of intestinal inflammation...
April 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/27577408/a-conformance-test-suite-for-arden-syntax-compilers-and-interpreters
#11
Klaus-Hendrik Wolf, Mike Klimek
The Arden Syntax for Medical Logic Modules is a standardized and well-established programming language to represent medical knowledge. To test the compliance level of existing compilers and interpreters no public test suite exists. This paper presents the research to transform the specification into a set of unit tests, represented in JUnit. It further reports on the utilization of the test suite testing four different Arden Syntax processors. The presented and compared results reveal the status conformance of the tested processors...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27549656/self-directed-learning-modules-of-ct-scan-images-to-improve-students-perception-of-gross-anatomy
#12
Pananghat Achutha Kumar, Ramakrishnan Jothi, Dharmalingam Mathivanan
BACKGROUND: A contemporary anatomy curriculum that aims to be clinically relevant requires medical students to be introduced to radiological anatomy in the preclinical years. Ideally, the curriculum should also support self-directed learning, a habit best instilled early. Based on these educational requirements, we designed an interesting and clinically-meaningful program of self-learning modules in radiological anatomy to augment students' learning of gross anatomy. The program is guided by current theories of learning, which emphasize an individualized learning pace for students...
May 2016: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/27318874/transformation-of-arden-syntax-s-medical-logic-modules-into-ardenml-for-a-business-rules-management-system
#13
Chai Young Jung, Jong-Ye Choi, Seong Jik Jeong, Kyunghee Cho, Yong Duk Koo, Jin Hee Bae, Sukil Kim
INTRODUCTION: Arden Syntax is a Health Level Seven International (HL7) standard language that is used for representing medical knowledge as logic statements. Arden Syntax Markup Language (ArdenML) is a new representation of Arden Syntax based on XML. Compilers are required to execute medical logic modules (MLMs) in the hospital environment. However, ArdenML may also replace the compiler. The purpose of this study is to demonstrate that MLMs, encoded in ArdenML, can be transformed into a commercial rule engine format through an XSLT stylesheet and made executable in a target system...
May 16, 2016: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/27139380/clinical-decision-support-for-the-classification-of-diabetic-retinopathy-a-comparison-of-manual-and-automated-results
#14
COMPARATIVE STUDY
Christoph Mitsch, Karsten Fehre, Sonja Prager, Christoph Scholda, Katharina Kriechbaum, Thomas Wrba, Ursula Schmidt-Erfurth
The management of diabetic retinopathy, a frequent ophthalmological manifestation of diabetes mellitus, consists of regular examinations and a standardized, manual classification of disease severity, which is used to recommend re-examination intervals. To evaluate the feasibility and safety of implementing automated, guideline-based diabetic retinopathy (DR) grading into clinical routine by applying established clinical decision support (CDS) technology. We compared manual with automated classification that was generated using medical documentation and an Arden server with a specific medical logic module...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27100986/-implementation-of-the-academic-day-for-undergraduate-interns
#15
COMPARATIVE STUDY
Ricardo Salas-Flores, Brian González-Pérez
BACKGROUND: Medical internship is an important period in the formation of a general (or medical) practitioner, in which the student becomes a member of the "health community" and also applies all the knowledge he or she has received during the university lectures. The present study aims to evaluate the impact of the implementation of the academic day programme designed for undergraduate medical interns within the Mexican second level healthcare Hospital General Regional No. 6 "Dr...
May 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/26639685/cognitive-it-systems-for-big-data-analysis-in-medicine
#16
J Isakova
BACKGROUND: Rapid development of medicine requires regular update of clinical data evidence. This task accomplishment requires participation of numerous specialists in evidence-based medicine, who are proficient in various statistical methods and can work with big data analysis tools in biomedical sciences. This, in turn, requires significant time and other resources. Today, at the peak of IT development, cognitive systems in the field of medicine with special technologies of data collection and analysis, is the start of a new trend...
2015: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/26603750/using-arden-syntax-for-the-creation-of-a-multi-patient-surveillance-dashboard
#17
Stefan Kraus, Caroline Drescher, Martin Sedlmayr, Ixchel Castellanos, Hans-Ulrich Prokosch, Dennis Toddenroth
OBJECTIVE: Most practically deployed Arden-Syntax-based clinical decision support (CDS) modules process data from individual patients. The specification of Arden Syntax, however, would in principle also support multi-patient CDS. The patient data management system (PDMS) at our local intensive care units does not natively support patient overviews from customizable CDS routines, but local physicians indicated a demand for multi-patient tabular overviews of important clinical parameters such as key laboratory measurements...
October 9, 2015: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/26573247/data-driven-knowledge-acquisition-validation-and-transformation-into-hl7-arden-syntax
#18
Maqbool Hussain, Muhammad Afzal, Taqdir Ali, Rahman Ali, Wajahat Ali Khan, Arif Jamshed, Sungyoung Lee, Byeong Ho Kang, Khalid Latif
OBJECTIVE: The objective of this study is to help a team of physicians and knowledge engineers acquire clinical knowledge from existing practices datasets for treatment of head and neck cancer, to validate the knowledge against published guidelines, to create refined rules, and to incorporate these rules into clinical workflow for clinical decision support. METHODS AND MATERIALS: A team of physicians (clinical domain experts) and knowledge engineers adapt an approach for modeling existing treatment practices into final executable clinical models...
October 28, 2015: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/26563776/assessing-the-feasibility-of-a-mobile-health-supported-clinical-decision-support-system-for-nutritional-triage-in-oncology-outpatients-using-arden-syntax
#19
Jeroen S de Bruin, Christian Schuh, Walter Seeling, Eva Luger, Michaela Gall, Elisabeth Hütterer, Gabriela Kornek, Bernhard Ludvik, Friedrich Hoppichler, Karin Schindler
BACKGROUND: Nutritional screening procedures followed by regular nutrition monitoring for oncological outpatients are no standard practice in many European hospital wards and outpatient settings. As a result, early signs of malnutrition are missed and nutritional treatment is initiated when patients have already experienced severe weight loss. OBJECTIVE: We report on a novel clinical decision support system (CDSS) for the global assessment and nutritional triage of the nutritional condition of oncology outpatients...
October 22, 2015: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/26549491/at-the-tip-of-an-iceberg-prenatal-marijuana-and-its-possible-relation-to-neuropsychiatric-outcome-in-the-offspring
#20
REVIEW
Alán Alpár, Vincenzo Di Marzo, Tibor Harkany
Endocannabinoids regulate brain development via modulating neural proliferation, migration, and the differentiation of lineage-committed cells. In the fetal nervous system, (endo)cannabinoid-sensing receptors and the enzymatic machinery of endocannabinoid metabolism exhibit a cellular distribution map different from that in the adult, implying distinct functions. Notably, cannabinoid receptors serve as molecular targets for the psychotropic plant-derived cannabis constituent Δ(9)-tetrahydrocannainol, as well as synthetic derivatives (designer drugs)...
April 1, 2016: Biological Psychiatry
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