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https://www.readbyqxmd.com/read/28623772/development-and-validation-of-a-highly-sensitive-lc-esi-ms-ms-method-for-estimation-of-iiim-mcd-211-a-novel-nitrofuranyl-methyl-piperazine-derivative-with-potential-activity-against-tuberculosis-application-to-drug-development
#1
Asmita Magotra, Anjna Sharma, Ajai Prakash Gupta, Priya Wazir, Shweta Sharma, Parvinder Pal Singh, Manoj Kumar Tikoo, Ram A Vishwakarma, Gurdarshan Singh, Utpal Nandi
In the present study, a simple, sensitive, specific and rapid liquid chromatography (LC) tandem mass spectrometry (MS/MS) method was developed and validated according to the Food and Drug Administration (FDA) guidelines for estimation of IIIM-MCD-211 (a potent oral candidate with promising action against tuberculosis) in mice plasma using carbamazepine as internal standard (IS). Bioanalytical method consisted of one step protein precipitation for sample preparation followed by quantitation in LC-MS/MS using positive electrospray ionization technique (ESI) operating in multiple reaction monitoring (MRM) mode...
June 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28619368/preliminary-evidence-for-associations-between-molecular-markers-and-quantitative-traits-in-a-set-of-bread-wheat-triticum-aestivum-l-cultivars-and-breeding-lines
#2
Babak Abdollahi Mandoulakani, Shilan Nasri, Sahar Dashchi, Sorour Arzhang, Iraj Bernousi, Hossein Abbasi Holasou
The identification of polymorphic markers associated with various quantitative traits allows us to test their performance for the exploitation of the extensive quantitative variation maintained in gene banks. In the current study, a set of 97 wheat germplasm accessions including 48 cultivars and 49 breeding lines were evaluated for 18 agronomic traits. The accessions were also genotyped with 23 ISSR, nine IRAP and 20 REMAP markers, generating a total of 658 clear and scorable bands, 86% of which were polymorphic...
June 12, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28588384/snp-based-association-analysis-for-seedling-traits-in-durum-wheat-triticum-turgidum-l-durum-desf
#3
Salih A I Sabiel, Sisi Huang, Xin Hu, Xifeng Ren, Chunjie Fu, Junhua Peng, Dongfa Sun
In the present study, 150 accessions of worldwide originated durum wheat germplasm (Triticum turgidum spp. durum) were observed for major seedling traits and their growth. The accessions were evaluated for major seedling traits under controlled conditions of hydroponics at the 13(th), 20(th), 27(th) and 34(th) day-after germination. Biomass traits were measured at the 34(th) day-after germination. Correlation analysis was conducted among the seedling traits and three field traits at maturity, plant height, grain weight and 1000-grain weight observed in four consecutive years...
March 2017: Breeding Science
https://www.readbyqxmd.com/read/28557723/microcystic-lymphatic-malformation-successfully-treated-with-topical-rapamycin
#4
Pablo García-Montero, Javier Del Boz, Miguel Sanchez-Martínez, Isabel María Escudero Santos, Eulalia Baselga
Microcystic lymphatic malformations (MLM) are low-flow vascular malformations composed of multiple small cysts. MLM usually affect deep-lying structures, which makes their treatment even more difficult and complex. A novel and interesting treatment is rapamycin, a mammalian target of rapamycin inhibitor that when orally administrated has offered favorable results. However, until recently, topical rapamycin had not been used in the treatment of MLM. Case 1 is a girl aged 13 years with extensive MLM affecting the muscles in the right buttock...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28549207/morphological-descriptors-and-issr-molecular-markers-in-the-evaluation-of-genetic-variability-of-tectona-grandis-genotypes
#5
A M Chimello, J G Jesus, P E Teodoro, A A B Rossi, K L Araújo, T N Marostega, L G Neves, M A A Barelli
This study aimed to evaluate the genetic variability of the teak germplasm bank, using morphological traits and inter-simple sequence repeat molecular markers. Thirty clones were evaluated in a randomized complete block design with three replicates, and each plot was composed of three plants. A joint analysis of quantitative and qualitative variables was performed using the Gower algorithm. Quantitative, qualitative, and molecular variables were analyzed simultaneously using the Ward-MLM procedure. There is genetic variability among the 30 teak genotypes studied, considering the quantitative, qualitative, and molecular variables by the Ward-MLM statistical procedure...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28508774/arden-syntax-mlm-building-blocks-for-microbiological-concepts-and-their-application-in-infection-surveillance
#6
Jeroen S de Bruin, Walter Koller, Julia Zeckl, Alexander Blacky, Andrea Rappelsberger, Klaus-Peter Adlassnig
BACKGROUND: The diagnosis - and hence definitions - of healthcare-associated infections (HAIs) rely on microbiological laboratory test results in specific constellations. OBJECTIVES: To construct a library that provides interoperable building blocks for the analysis of microbiological laboratory test results. METHODS: We used Java for preprocessing raw microbiological laboratory test results and Arden Syntax for knowledge-based querying of data based on microbiology information elements used in European surveillance criteria for HAIs...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28507551/deciphering-genomic-regions-for-high-grain-iron-and-zinc-content-using-association-mapping-in-pearl-millet
#7
N Anuradha, C Tara Satyavathi, C Bharadwaj, T Nepolean, S Mukesh Sankar, Sumer P Singh, Mahesh C Meena, Tripti Singhal, Rakesh K Srivastava
Micronutrient malnutrition, especially deficiency of two mineral elements, iron [Fe] and zinc [Zn] in the developing world needs urgent attention. Pearl millet is one of the best crops with many nutritional properties and is accessible to the poor. We report findings of the first attempt to mine favorable alleles for grain iron and zinc content through association mapping in pearl millet. An association mapping panel of 130 diverse lines was evaluated at Delhi, Jodhpur and Dharwad, representing all the three pearl millet growing agro-climatic zones of India, during 2014 and 2015...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28474405/teaching-leadership-the-medical-student-society-model
#8
Jacob H Matthews, Gabriella L Morley, Eleanor Crossley, Shivam Bhanderi
BACKGROUND: All health care professionals in the UK are expected to have the medical leadership and management (MLM) skills necessary for improving patient care, as stipulated by the UK General Medical Council (GMC). CONTEXT: Newly graduated doctors reported insufficient knowledge about leadership and quality improvement skills, despite all UK medical schools reporting that MLM is taught within their curriculum. INNOVATION: A medical student society organised a series of extracurricular educational events focusing on leadership topics...
May 5, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/28433825/a-distributed-framework-for-health-information-exchange-using-smartphone-technologies
#9
Mohamed Abdulnabi, Ahmed Al-Haiqi, Mlm Kiah, A A Zaidan, B B Zaidan, Muzammil Hussein
Nationwide health information exchange (NHIE) continues to be a persistent concern for government agencies, despite the many efforts and the conceived benefits of sharing patient data among healthcare providers. Difficulties in ensuring global connectivity, interoperability, and concerns on security have always hampered the government from successfully deploying NHIE. By looking at NHIE from a fresh perspective and bearing in mind the pervasiveness and power of modern mobile platforms, this paper proposes a new approach to NHIE that builds on the notion of consumer-mediated HIE, albeit without the focus on central health record banks...
April 19, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28408910/new-hypervariable-ssr-markers-for-diversity-analysis-hybrid-purity-testing-and-trait-mapping-in-pigeonpea-cajanus-cajan-l-millspaugh
#10
Abhishek Bohra, Rintu Jha, Gaurav Pandey, Prakash G Patil, Rachit K Saxena, Indra P Singh, D Singh, R K Mishra, Ankita Mishra, F Singh, Rajeev K Varshney, N P Singh
Draft genome sequence in pigeonpea offers unprecedented opportunities for genomics assisted crop improvement via enabling access to genome-wide genetic markers. In the present study, 421 hypervariable simple sequence repeat (SSR) markers from the pigeonpea genome were screened on a panel of eight pigeonpea genotypes yielding marker validation and polymorphism percentages of 95.24 and 54.11%, respectively. The SSR marker assay uncovered a total of 570 alleles with three as an average number of alleles per marker...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28319690/depression-and-executive-functioning-deficits-predict-poor-occupational-functioning-in-a-large-longitudinal-sample-with-bipolar-disorder
#11
Lisa A O'Donnell, Patricia J Deldin, Andrew Grogan-Kaylor, Melvin G McInnis, Jenna Weintraub, Kelly A Ryan, Joseph A Himle
BACKGROUND: Bipolar Disorder (BD) is characterized by impairments in psychosocial functioning with occupational disability being one of the most significant. Depression and neurocognitive deficits are features of BD most commonly associated with poor occupational functioning (OF). Few studies have examined these features over an extended period of time focusing on distinct aspects of work functioning. METHODS: This longitudinal study included 273 adults with bipolar I disorder (N=173), bipolar II disorder (N=69), and bipolar not otherwise specified (N=31)...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28317806/mycobacterium-lepraemurium-uses-tlr-6-and-mr-but-not-lipid-rafts-or-dc-sign-to-gain-access-into-mouse-macrophages
#12
Mayra Silva-Miranda, Patricia Arce-Paredes, Oscar Rojas-Espinosa
OBJECTIVE/BACKGROUND: Mycobacterium lepraemurium (MLM), the etiologic agent of murine leprosy, is an intracellular parasite of macrophages; the mechanism used by this bacterium to enter macrophages is not known. The fate of the MLM phagosome inside macrophages is also unknown. This study was conducted to investigate how MLM enters macrophages and to define the maturation process of MLM phagosome inside macrophages. MATERIALS AND METHODS: Peritoneal macrophages were incubated in the presence of mannan-bovine serum albumin (BSA), and antibodies to known macrophage receptors, including, anti-FcγRIII/RII (anti-CD16/32), anti-CD35 (anti-CR1), anti-TLR2, anti-TLR4, anti-TLR6, anti-CD14, and anti-dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317774/development-of-an-up-grading-process-to-produce-mlm-structured-lipids-from-sardine-discards
#13
R Morales-Medina, M Munio, A Guadix, E M Guadix
The aim of the work was to produce MLM structured lipids with caprylic acid (M) as medium chain fatty acid located at the external bonds of the glycerol backbone and concentrated polyunsaturated fatty acids (L) from sardine discards (Sardine pilchardus) in the central bond of the glycerol. To that end, the following steps were conducted: (i) fish oil extraction, (ii) Omega-3 free fatty acids (FFA) concentration (low temperature winterization), (iii) two-steps enzymatic esterification and (iv) triacylglycerols (TAG) purification (liquid column chromatography)...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28295717/genome-wide-association-study-of-cell-mediated-immune-response-in-chicken
#14
V Raeesi, A Ehsani, R V Torshizi, M Sargolzaei, A A Masoudi, R Dideban
Cell-mediated immunity (CMI) causes the intracellular destruction of the antigen or elimination of the host cell to make animals resistant against exogenous antigens and cancers. In this study, a genome-wide association study (GWAS) was carried out to identify genomic regions associated with CMI in chicken using chicken 60k high-density single nucleotide polymorphism (SNP) array. Genomic relationships were taken into account to adjust for population structure. In order to account for multiple testing, chromosome-wise false discovery rate was controlled at 5% and 10% levels...
March 10, 2017: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/28259245/the-efficacy-of-a-relationship-building-intervention-in-5th-grade
#15
Cindy Faith Miller, Karen P Kochel, Lorey A Wheeler, Kimberly A Updegraff, Richard A Fabes, Carol Lynn Martin, Laura D Hanish
The present study reports initial efficacy data for a new school-based intervention - the Relationship Building Intervention (RBI) - that includes a series of teacher-facilitated, structured activities designed to promote positive peer relationships and inclusive classroom communities. The RBI was evaluated in fifth-grade classrooms by estimating multilevel model (MLM) analyses of covariance (ANCOVA) comparing 368 fifth-grade students in intervention classrooms with 259 fifth-graders in control classrooms on social behaviors, perceptions of classroom connectedness, and academic performance...
April 2017: Journal of School Psychology
https://www.readbyqxmd.com/read/28255670/detection-and-validation-of-genomic-regions-associated-with-resistance-to-rust-diseases-in-a-worldwide-hexaploid-wheat-landrace-collection-using-bayesr-and-mixed-linear-model-approaches
#16
Raj K Pasam, Urmil Bansal, Hans D Daetwyler, Kerrie L Forrest, Debbie Wong, Joanna Petkowski, Nicholas Willey, Mandeep Randhawa, Mumta Chhetri, Hanif Miah, Josquin Tibbits, Harbans Bariana, Matthew J Hayden
BayesR and MLM association mapping approaches in common wheat landraces were used to identify genomic regions conferring resistance to Yr, Lr, and Sr diseases. Deployment of rust resistant cultivars is the most economically effective and environmentally friendly strategy to control rust diseases in wheat. However, the highly evolving nature of wheat rust pathogens demands continued identification, characterization, and transfer of new resistance alleles into new varieties to achieve durable rust control. In this study, we undertook genome-wide association studies (GWAS) using a mixed linear model (MLM) and the Bayesian multilocus method (BayesR) to identify QTL contributing to leaf rust (Lr), stem rust (Sr), and stripe rust (Yr) resistance...
April 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28250596/genetic-diversity-population-structure-and-association-analysis-in-linseed-linum-usitatissimum-l
#17
Chandrawati, Neha Singh, Rajendra Kumar, Sujit Kumar, P K Singh, V K Yadav, S A Ranade, Hemant Kumar Yadav
The present investigation aimed to explore the level of genetic diversity, determine the population structure in a larger set of germplasm of linseed using microsatellite marker and identify linked markers through association mapping. A total of 168 accessions of linseed were evaluated for major agro-economic traits and SSRs markers deployed for diversity assessment. A total of 337 alleles were amplified by 50 SSRs ranging from 2 to 13 with an average of 6.74 ± 2.8 alleles per loci. The neighbor joining based clustering grouped all the accessions into three major clusters that were also confirmed by scatter plot of PCoA...
January 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/28230417/aging-and-half-ironman-performance
#18
M J Stones, Adric Hartin
Background/Study Context: Previous research on triathlon performance analyzed age trends for the Top Ten or Top Five finishers in world championship or national races at Olympic, Half-Ironman, and Ironman distances. The findings indicated higher age declines and/or earlier onset of decline in swimming and running than cycling. However, the designs of those studies took no account of possible differences between cross-sectional and longitudinal trends (i.e., cohort differences versus age changes). METHODS: This study analyzed performance times over the inaugural 5 years of the Half-Ironman world championship held in Clearwater, Florida, from 2006 to 2010...
March 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28225554/person-specific-versus-multilevel-autoregressive-models-accuracy-in-parameter%C3%A2-estimates-at-the-population-and-individual-levels
#19
Siwei Liu
This paper compares the multilevel modelling (MLM) approach and the person-specific (PS) modelling approach in examining autoregressive (AR) relations with intensive longitudinal data. Two simulation studies are conducted to examine the influences of sample heterogeneity, time series length, sample size, and distribution of individual level AR coefficients on the accuracy of AR estimates, both at the population level and at the individual level. It is found that MLM generally outperforms the PS approach under two conditions: when the sample has a homogeneous AR pattern, namely, when all individuals in the sample are characterized by AR processes with the same order; and when the sample has heterogeneous AR patterns, but a multilevel model with a sufficiently high order (i...
February 22, 2017: British Journal of Mathematical and Statistical Psychology
https://www.readbyqxmd.com/read/28223814/the-dynamic-relationship-between-emotional-and-physical-states-an-observational-study-of-personal-health-records
#20
Ye-Seul Lee, Won-Mo Jung, Hyunchul Jang, Sanghyun Kim, Sun-Yong Chung, Younbyoung Chae
OBJECTIVES: Recently, there has been increasing interest in preventing and managing diseases both inside and outside medical institutions, and these concerns have supported the development of the individual Personal Health Record (PHR). Thus, the current study created a mobile platform called "Mind Mirror" to evaluate psychological and physical conditions and investigated whether PHRs would be a useful tool for assessment of the dynamic relationship between the emotional and physical conditions of an individual...
2017: Neuropsychiatric Disease and Treatment
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