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https://www.readbyqxmd.com/read/28053503/assessment-of-ischemia-in-acute-central-retinal-vein-occlusion-from-inner-retinal-reflectivity-on-spectral-domain-optical-coherence-tomography
#1
David J Browning, Omar S Punjabi, Chong Lee
PURPOSE: To determine the relationship between different spectral domain optical coherence tomography (SD-OCT) signs of retinal ischemia in acute central retinal vein occlusion (CRVO) and whether they predict anterior segment neovascularization (ASNV). DESIGN: Retrospective, observational study. SUBJECTS: Thirty-nine consecutive patients with acute CRVO and 12 months of follow-up. METHODS: We graded baseline SD-OCTs for increased reflectivity of the inner retina, loss of definition of inner retinal layers, presence of a prominent middle-limiting membrane (p-MLM) sign, and presence of paracentral acute middle maculopathy (PAMM)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28017371/mixed-model-association-with-family-biased-case-control-ascertainment
#2
Tristan J Hayeck, Po-Ru Loh, Samuela Pollack, Alexander Gusev, Nick Patterson, Noah A Zaitlen, Alkes L Price
Mixed models have become the tool of choice for genetic association studies; however, standard mixed model methods may be poorly calibrated or underpowered under family sampling bias and/or case-control ascertainment. Previously, we introduced a liability threshold-based mixed model association statistic (LTMLM) to address case-control ascertainment in unrelated samples. Here, we consider family-biased case-control ascertainment, where case and control subjects are ascertained non-randomly with respect to family relatedness...
January 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27977845/stuck-in-limbo-motivational-antecedents-and-consequences-of-experiencing-action-crises-in-personal-goal-pursuit
#3
Anne C Holding, Nora H Hope, Brenda Harvey, Ariane S Marion Jetten, Richard Koestner
OBJECTIVE: Action crises describe the intrapsychic conflicts individuals experience when they feel torn between further goal pursuit and goal disengagement. The present investigation introduces autonomous and controlled motivation as independent predictors of action crisis severity, beyond known personality level predictors (action orientation), and novel personality level predictors (neuroticism and conscientiousness). METHOD: Using a multi-wave prospective longitudinal design and multilevel modeling (MLM) we followed students pursuing 3 personal goals across an academic semester (N = 425 undergraduates, 76% female, 57% Caucasian, Mage = 20...
December 15, 2016: Journal of Personality
https://www.readbyqxmd.com/read/27936303/using-multiple-group-modeling-to-test-moderators-in-meta-analysis
#4
Alexander M Schoemann
Meta-analysis is a popular and flexible analysis that can be fit in many modeling frameworks. Two methods of fitting meta-analyses that are growing in popularity are structural equation modeling (SEM) and multilevel modeling (MLM). By using SEM or MLM to fit a meta-analysis researchers have access to powerful techniques associated with SEM and MLM. This paper details how to use one such technique, multiple group analysis, to test categorical moderators in meta-analysis. In a multiple group meta-analysis a model is fit to each level of the moderator simultaneously...
December 2016: Research Synthesis Methods
https://www.readbyqxmd.com/read/27933004/policy-implications-of-achievement-testing-using-multilevel-models-the-case-of-brazilian-elementary-schools
#5
Igor G Menezes, Victor R Duran, Euclides J Mendonça Filho, Tainã J Veloso, Stella M S Sarmento, Christine L Paget, Kai Ruggeri
Large-scale educational assessment has been established as source of descriptive, evaluative and interpretative information that influence educational policies worldwide throughout the last third of the twentieth century. In the 1990s the Brazilian Ministry of Education developed the National Basic Education Assessment System (SAEB) that regularly measures management, resource and contextual school features and academic achievement in public and private institutions. In 2005, after significant piloting and review of the SAEB, a new sampling strategy was taken and Prova Brasil became the new instrument used by the Ministry to assess skills in Portuguese (reading comprehension) and Mathematics (problem solving), as well as collecting contextual information concerning the school, principal, teacher, and the students...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27924947/two-genomic-regions-associated-with-fiber-quality-traits-in-chinese-upland-cotton-under-apparent-breeding-selection
#6
Junji Su, Libei Li, Chaoyou Pang, Hengling Wei, Caixiang Wang, Meizhen Song, Hantao Wang, Shuqi Zhao, Chi Zhang, Guangzhi Mao, Long Huang, Chengshe Wang, Shuli Fan, Shuxun Yu
Fiber quality is one of the most important agronomic traits of cotton, and understanding the genetic basis of its target traits will accelerate improvements to cotton fiber quality. In this study, a panel comprising 355 upland cotton accessions was used to perform genome-wide association studies (GWASs) of five fiber quality traits in four environments. A total of 16, 10 and 7 SNPs were associated with fiber length (FL), fiber strength (FS) and fiber uniformity (FU), respectively, based on the mixed linear model (MLM)...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917131/the-challenge-of-fostering-healthy-organizations-an-empirical-study-on-the-role-of-workplace-relational-civility-in-acceptance-of-change-and-well-being
#7
Annamaria Di Fabio, Marco Giannini, Yura Loscalzo, Letizia Palazzeschi, Ornella Bucci, Andrea Guazzini, Alessio Gori
The world of work in the twenty-first century is characterized by globalization, instability, and unavoidable change. Organizations need to develop a positive relational environment in the workplace thereby enabling workers to enhance their personal resources in order to face with on-going changes in the sphere of work for promoting their well-being. Against this background, the aim of this research was to examine the relationship between workplace relational civility and both acceptance of change and well-being (hedonic well-being as well as eudaimonic well-being) beyond the effect of personality traits...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27915055/identification-of-human-udp-glucuronosyltransferase-isoforms-involved-in-the-isofraxidin-glucuronidation-and-assessment-of-the-species-differences-of-the-reaction
#8
Fanxing Meng, Yan Li, Guiyuan He, Guangbo Ge, Shumin Liu
Isofraxidin, 7-Hydroxy-6.8-dimethoxy-2H-1-benzopyran-2-one, is a major active component of Acanthopanax senticosus, which has been used as Acanthopanax (Ciwujia) injection to treat cardiovascular and cerebrovascular diseases in China for more than thirty years. The purpose of this study was to identify the roles of human UDP-glucuronosyltransferases (UGTs) in isofraxidin glucuronidation in the liver and intestinal microsomes and to reveal the potential species differences by comparing the liver microsomal glucuronidation from different experimental animals...
November 30, 2016: Fitoterapia
https://www.readbyqxmd.com/read/27905018/minimal-excision-and-primary-suture-is-a-cost-efficient-definitive-treatment-for-pilonidal-disease-with-low-morbidity-a-population-based-interventional-and-a-cross-sectional-cohort-study
#9
Kaveh Khodakaram, Joachim Stark, Ida Höglund, Roland E Andersson
BACKGROUND: Conventional treatment of pilonidal disease with wide excision is associated with high morbidity. We describe the short- and long-term results and the impact on the health care system of a simple operation performed in the office under local anaesthesia, consisting of minimal excision of pilonidal sinuses with primary suture-the modified Lord-Millar operation (mLM). METHODS: All patients operated with mLM from February 2008 till November 2012 were prospectively followed for recurrence by telephone interviews and examination of symptomatic patients till July 2015...
November 30, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27902805/genome-wide-association-mapping-reveals-novel-qtl-for-seedling-leaf-rust-resistance-in-a-worldwide-collection-of-winter-wheat
#10
Genqiao Li, Xiangyang Xu, Guihua Bai, Brett F Carver, Robert Hunger, J Michael Bonman, James Kolmer, Hongxu Dong
Leaf rust of wheat ( L.) is a major disease that causes significant yield losses worldwide. The short-lived nature of leaf rust resistance () genes necessitates a continuous search for novel sources of resistance. We performed a genome-wide association study (GWAS) on a panel of 1596 wheat accessions. The panel was evaluated for leaf rust reaction by testing with a bulk of Eriks. () isolates collected from multiple fields of Oklahoma in 2013 and two predominant races in the fields of Oklahoma in 2015. The panel was genotyped with a set of 5011 single-nucleotide polymorphism (SNP) markers...
November 2016: Plant Genome
https://www.readbyqxmd.com/read/27898827/identification-of-genomic-loci-associated-with-the-photochemical-reflectance-index-by-genome-wide-association-study-in-soybean
#11
Matthew Herritt, Arun Prabhu Dhanapal, Felix B Fritschi
The photochemical reflectance index (PRI) is determined from canopy spectral reflectance measurements and can provide important information about photosynthesis. The PRI can be used to assess the epoxidation state of xanthophyll pigments, which provides information on nonphotochemical quenching (NPQ) and the amount of energy used for photosynthesis. Genome-wide association analyses were conducted to identify single-nucleotide polymorphisms (SNPs) and genomic loci associated with PRI using data from a soybean [ (L...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27885104/could-vitamin-c-and-zinc-chloride-protect-the-germ-cells-against-sodium-arsenite
#12
L S Altoé, I B Reis, Mlm Gomes, H Dolder, Jc Monteiro Pirovani
Arsenic (As) is commonly associated with natural and human processes such as volcanic emissions, mining and herbicides production, being an important pollutant. Several studies have associated As intake with male fertility reduction, thus the aim of the present study was to evaluate whether vitamin C and/or zinc would counteract As side effects within the testicles. Adult male Wistar rats were divided into six experimental groups: control, sodium arsenite (5 mg/kg/day), vitamin C (100 mg/kg/day), zinc chloride (ZnCl2; 20 mg/kg/day), sodium arsenite + vitamin C and sodium arsenite + ZnCl2 Testicles and epididymis were harvested and either frozen or routinely processed to be embedded in glycol methacrylate resin...
November 24, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27808356/genetic-divergence-through-joint-analysis-of-morphoagronomic-and-molecular-characters-in-accessions-of-jatropha-curcas
#13
C N Pestana-Caldas, S A Silva, E L Machado, D R de Souza, E C Cerqueira-Pereira, M S Silva
The aim of this study was to investigate the genetic divergence between accessions of Jatropha curcas through joint analysis of morphoagronomic and molecular characters. To this end, we investigated 11 morphoagronomic characters and performed molecular genotyping, using 23 inter-simple sequence repeat (ISSR) primers in 46 accessions of J. curcas. We calculated the contribution of each character on divergence using analysis of variance. The grouping among accessions was performed using the Ward-MLM (modified location model) method, using morphoagronomic and molecular data, whereas the cophenetic correlation was obtained based on Gower's algorithm...
October 5, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27803267/what-s-the-rush-tort-laws-and-elective-early-term-induction-of-labor
#14
Louise Marie Roth
Tort laws aim to deter risky medical practices and increase accountability for harm. This research examines their effects on deterrence of a high-risk obstetric practice in the United States: elective early-term (37-38 weeks gestation) induction of labor. Using birth certificate data from the Natality Detail Files and state-level data from publicly available sources, this study analyzes the effects of tort laws on labor induction with multilevel models (MLM) of 665,491 early-term births nested in states. Results reveal that caps on damages are associated with significantly higher odds of early-term induction and Proportionate Liability (PL) is associated with significantly lower odds compared to Joint and Several Liability (JSL)...
November 1, 2016: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/27756789/application-of-mice-humanized-for-cyp2d6-to-the-study-of-tamoxifen-metabolism-and-drug-drug-interaction-with-antidepressants
#15
A Kenneth MacLeod, Lesley A McLaughlin, Colin J Henderson, C Roland Wolf
Tamoxifen is an estrogen receptor antagonist used in the treatment of breast cancer. It is a prodrug that is converted by several cytochrome P450 enzymes to a primary metabolite, N-desmethyltamoxifen (NDT), which is then further modified by CYP2D6 to a pharmacologically potent secondary metabolite, 4-hydroxy-N-desmethyltamoxifen (endoxifen). Antidepressants (ADs), which are often coprescribed to patients receiving tamoxifen, are also metabolized by CYP2D6 and evidence suggests that a drug-drug interaction between these agents adversely affects the outcome of tamoxifen therapy by inhibiting endoxifen formation...
January 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27751660/measuring-recovery-an-adapted-brief-assessment-of-mood-bam-compared-to-biochemical-and-power-output-alterations
#16
David A Shearer, William Sparkes, Jonny Northeast, Daniel J Cunningham, Christian J Cook, Liam P Kilduff
OBJECTIVES: Biochemical (e.g. creatine kinase (CK)) and neuromuscular (e.g. peak power output (PPO)) markers of recovery are expensive and require specialist equipment. Perceptual measures are an effective alternative, yet most validated scales are too long for daily use. DESIGN: This study utilises a longitudinal multi-level design to test an adapted Brief Assessment of Mood (BAM+), with four extra items and a 100mm visual analogue scale to measure recovery. METHODS: Elite under-21 academy soccer players (N=11) were monitored across five games with data (BAM+, CK and PPO) collected for each game at 24h pre, 24h and 48h post-match...
October 5, 2016: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/27700475/leadership-and-management-in-uk-medical-school-curricula
#17
Richard Jefferies, Ibrahim H N Sheriff, Jacob H Matthews, Olivia Jagger, Sarah Curtis, Peter Lees, Peter C Spurgeon, Daniel Mark Fountain
Purpose Although medical leadership and management (MLM) is increasingly being recognised as important to improving healthcare outcomes, little is understood about current training of medical students in MLM skills and behaviours in the UK. The paper aims to discuss these issues. Design/methodology/approach This qualitative study used validated structured interviews with expert faculty members from medical schools across the UK to ascertain MLM framework integration, teaching methods employed, evaluation methods and barriers to improvement...
October 10, 2016: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/27672353/anxiety-sensitivity-and-smoking-variability-among-treatment-seeking-smokers
#18
Mark B Powers, Michelle L Davis, Brooke Y Kauffman, Scarlett O Baird, Michael Zvolensky, David Rosenfield, Bess H Marcus, Timothy S Church, Georita Frierson, Michael W Otto, Jasper A J Smits
OBJECTIVES: Anxiety sensitivity (AS) is associated with poor smoking cessation outcomes. One reason may be that smokers with high AS smoke differently (i.e., to manage negative affect and uncomfortable bodily sensations) than other smokers, leading to stronger addiction (due to an affect/sensation based and thereby highly variable rather than a regular smoking routine). Thus, we examined the relationship between AS and smoking variability in a group of treatment-seeking smokers. METHODS: Participants (N = 136; 52...
September 2016: Addictive Disorders & Their Treatment
https://www.readbyqxmd.com/read/27634218/dna-methylation-profiling-of-esophageal-adenocarcinoma-using-methylation-ligation-dependent-macroarray-mlm
#19
Isabelle Guilleret, Lorena Losi, Sonia T Chelbi, Sergio Fonda, Stéphanie Bougel, Sara Saponaro, Gaia Gozzi, Loredana Alberti, Richard Braunschweig, Jean Benhattar
Most types of cancer cells are characterized by aberrant methylation of promoter genes. In this study, we described a rapid, reproducible, and relatively inexpensive approach allowing the detection of multiple human methylated promoter genes from many tissue samples, without the need of bisulfite conversion. The Methylation Ligation-dependent Macroarray (MLM), an array-based analysis, was designed in order to measure methylation levels of 58 genes previously described as putative biomarkers of cancer. The performance of the design was proven by screening the methylation profile of DNA from esophageal cell lines, as well as microdissected formalin-fixed and paraffin-embedded (FFPE) tissues from esophageal adenocarcinoma (EAC)...
October 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27617019/association-mapping-of-main-tomato-fruit-sugars-and-organic-acids
#20
Jiantao Zhao, Yao Xu, Qin Ding, Xinli Huang, Yating Zhang, Zhirong Zou, Mingjun Li, Lu Cui, Jing Zhang
Association mapping has been widely used to map the significant associated loci responsible for natural variation in complex traits and are valuable for crop improvement. Sugars and organic acids are the most important metabolites in tomato fruits. We used a collection of 174 tomato accessions composed of Solanum lycopersicum (123 accessions) and S. lycopersicum var cerasiforme (51 accessions) to detect significantly associated loci controlling the variation of main sugars and organic acids. The accessions were genotyped with 182 SSRs spreading over the tomato genome...
2016: Frontiers in Plant Science
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