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https://www.readbyqxmd.com/read/28319690/depression-and-executive-functioning-deficits-predict-poor-occupational-functioning-in-a-large-longitudinal-sample-with-bipolar-disorder
#1
Lisa A O'Donnell, Patricia J Deldin, Andrew Grogan-Kaylor, Melvin G McInnis, Jenna Weintraub, Kelly A Ryan, Joseph A Himle
BACKGROUND: Bipolar Disorder (BD) is characterized by impairments in psychosocial functioning with occupational disability being one of the most significant. Depression and neurocognitive deficits are features of BD most commonly associated with poor occupational functioning (OF). Few studies have examined these features over an extended period of time focusing on distinct aspects of work functioning. METHODS: This longitudinal study included 273 adults with bipolar I disorder (N=173), bipolar II disorder (N=69), and bipolar not otherwise specified (N=31)...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28317806/mycobacterium-lepraemurium-uses-tlr-6-and-mr-but-not-lipid-rafts-or-dc-sign-to-gain-access-into-mouse-macrophages
#2
Mayra Silva-Miranda, Patricia Arce-Paredes, Oscar Rojas-Espinosa
OBJECTIVE/BACKGROUND: Mycobacterium lepraemurium (MLM), the etiologic agent of murine leprosy, is an intracellular parasite of macrophages; the mechanism used by this bacterium to enter macrophages is not known. The fate of the MLM phagosome inside macrophages is also unknown. This study was conducted to investigate how MLM enters macrophages and to define the maturation process of MLM phagosome inside macrophages. MATERIALS AND METHODS: Peritoneal macrophages were incubated in the presence of mannan-bovine serum albumin (BSA), and antibodies to known macrophage receptors, including, anti-FcγRIII/RII (anti-CD16/32), anti-CD35 (anti-CR1), anti-TLR2, anti-TLR4, anti-TLR6, anti-CD14, and anti-dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317774/development-of-an-up-grading-process-to-produce-mlm-structured-lipids-from-sardine-discards
#3
R Morales-Medina, M Munio, A Guadix, E M Guadix
The aim of the work was to produce MLM structured lipids with caprylic acid (M) as medium chain fatty acid located at the external bonds of the glycerol backbone and concentrated polyunsaturated fatty acids (L) from sardine discards (Sardine pilchardus) in the central bond of the glycerol. To that end, the following steps were conducted: (i) fish oil extraction, (ii) Omega-3 free fatty acids (FFA) concentration (low temperature winterization), (iii) two-steps enzymatic esterification and (iv) triacylglycerols (TAG) purification (liquid column chromatography)...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28295717/genome-wide-association-study-of-cell-mediated-immune-response-in-chicken
#4
V Raeesi, A Ehsani, R V Torshizi, M Sargolzaei, A A Masoudi, R Dideban
Cell-mediated immunity (CMI) causes the intracellular destruction of the antigen or elimination of the host cell to make animals resistant against exogenous antigens and cancers. In this study, a genome-wide association study (GWAS) was carried out to identify genomic regions associated with CMI in chicken using chicken 60k high-density single nucleotide polymorphism (SNP) array. Genomic relationships were taken into account to adjust for population structure. In order to account for multiple testing, chromosome-wise false discovery rate was controlled at 5% and 10% levels...
March 10, 2017: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/28259245/the-efficacy-of-a-relationship-building-intervention-in-5th-grade
#5
Cindy Faith Miller, Karen P Kochel, Lorey A Wheeler, Kimberly A Updegraff, Richard A Fabes, Carol Lynn Martin, Laura D Hanish
The present study reports initial efficacy data for a new school-based intervention - the Relationship Building Intervention (RBI) - that includes a series of teacher-facilitated, structured activities designed to promote positive peer relationships and inclusive classroom communities. The RBI was evaluated in fifth-grade classrooms by estimating multilevel model (MLM) analyses of covariance (ANCOVA) comparing 368 fifth-grade students in intervention classrooms with 259 fifth-graders in control classrooms on social behaviors, perceptions of classroom connectedness, and academic performance...
April 2017: Journal of School Psychology
https://www.readbyqxmd.com/read/28255670/detection-and-validation-of-genomic-regions-associated-with-resistance-to-rust-diseases-in-a-worldwide-hexaploid-wheat-landrace-collection-using-bayesr-and-mixed-linear-model-approaches
#6
Raj K Pasam, Urmil Bansal, Hans D Daetwyler, Kerrie L Forrest, Debbie Wong, Joanna Petkowski, Nicholas Willey, Mandeep Randhawa, Mumta Chhetri, Hanif Miah, Josquin Tibbits, Harbans Bariana, Matthew J Hayden
BayesR and MLM association mapping approaches in common wheat landraces were used to identify genomic regions conferring resistance to Yr, Lr, and Sr diseases. Deployment of rust resistant cultivars is the most economically effective and environmentally friendly strategy to control rust diseases in wheat. However, the highly evolving nature of wheat rust pathogens demands continued identification, characterization, and transfer of new resistance alleles into new varieties to achieve durable rust control. In this study, we undertook genome-wide association studies (GWAS) using a mixed linear model (MLM) and the Bayesian multilocus method (BayesR) to identify QTL contributing to leaf rust (Lr), stem rust (Sr), and stripe rust (Yr) resistance...
March 2, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28250596/genetic-diversity-population-structure-and-association-analysis-in-linseed-linum-usitatissimum-l
#7
Chandrawati, Neha Singh, Rajendra Kumar, Sujit Kumar, P K Singh, V K Yadav, S A Ranade, Hemant Kumar Yadav
The present investigation aimed to explore the level of genetic diversity, determine the population structure in a larger set of germplasm of linseed using microsatellite marker and identify linked markers through association mapping. A total of 168 accessions of linseed were evaluated for major agro-economic traits and SSRs markers deployed for diversity assessment. A total of 337 alleles were amplified by 50 SSRs ranging from 2 to 13 with an average of 6.74 ± 2.8 alleles per loci. The neighbor joining based clustering grouped all the accessions into three major clusters that were also confirmed by scatter plot of PCoA...
January 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/28230417/aging-and-half-ironman-performance
#8
M J Stones, Adric Hartin
Background/Study Context: Previous research on triathlon performance analyzed age trends for the Top Ten or Top Five finishers in world championship or national races at Olympic, Half-Ironman, and Ironman distances. The findings indicated higher age declines and/or earlier onset of decline in swimming and running than cycling. However, the designs of those studies took no account of possible differences between cross-sectional and longitudinal trends (i.e., cohort differences versus age changes). METHODS: This study analyzed performance times over the inaugural 5 years of the Half-Ironman world championship held in Clearwater, Florida, from 2006 to 2010...
March 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28225554/person-specific-versus-multilevel-autoregressive-models-accuracy-in-parameter%C3%A2-estimates-at-the-population-and-individual-levels
#9
Siwei Liu
This paper compares the multilevel modelling (MLM) approach and the person-specific (PS) modelling approach in examining autoregressive (AR) relations with intensive longitudinal data. Two simulation studies are conducted to examine the influences of sample heterogeneity, time series length, sample size, and distribution of individual level AR coefficients on the accuracy of AR estimates, both at the population level and at the individual level. It is found that MLM generally outperforms the PS approach under two conditions: when the sample has a homogeneous AR pattern, namely, when all individuals in the sample are characterized by AR processes with the same order; and when the sample has heterogeneous AR patterns, but a multilevel model with a sufficiently high order (i...
February 22, 2017: British Journal of Mathematical and Statistical Psychology
https://www.readbyqxmd.com/read/28223814/the-dynamic-relationship-between-emotional-and-physical-states-an-observational-study-of-personal-health-records
#10
Ye-Seul Lee, Won-Mo Jung, Hyunchul Jang, Sanghyun Kim, Sun-Yong Chung, Younbyoung Chae
OBJECTIVES: Recently, there has been increasing interest in preventing and managing diseases both inside and outside medical institutions, and these concerns have supported the development of the individual Personal Health Record (PHR). Thus, the current study created a mobile platform called "Mind Mirror" to evaluate psychological and physical conditions and investigated whether PHRs would be a useful tool for assessment of the dynamic relationship between the emotional and physical conditions of an individual...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28198509/multivariate-approach-in-popcorn-genotypes-using-the-ward-mlm-strategy-morpho-agronomic-analysis-and-incidence-of-fusarium-spp
#11
R N F Kurosawa, A T do Amaral Junior, F H L Silva, A Dos Santos, M Vivas, S H Kamphorst, G F Pena
The multivariate analyses are useful tools to estimate the genetic variability between accessions. In the breeding programs, the Ward-Modified Location Model (MLM) multivariate method has been a powerful strategy to quantify variability using quantitative and qualitative variables simultaneously. The present study was proposed in view of the dearth of information about popcorn breeding programs under a multivariate approach using the Ward-MLM methodology. The objective of this study was thus to estimate the genetic diversity among 37 genotypes of popcorn aiming to identify divergent groups associated with morpho-agronomic traits and traits related to resistance to Fusarium spp...
February 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28192462/development-identification-and-validation-of-caps-marker-for-shell-trait-which-governs-dura-pisifera-and-tenera-fruit-forms-in-oil-palm-elaeis-guineensis-jacq
#12
B Kalyana Babu, R K Mathur, P Naveen Kumar, D Ramajayam, G Ravichandran, M V B Venu, S Sparjan Babu
The oil palm fruit forms (dura, pisifera and tenera) governed by the shell thickness gene (Sh) plays a major role in identification of fruit type and also influences palm oil yield. Identification of desired fruit type is a major asset to the breeders and oil palm workers for applications in breeding, seed certification and to reduce time, space and money spent on identification of fruit form. In the present study, we developed Sh gene specific primer pairs and bulk segregant analysis was done using 300 genomic and 8 genic SSR markers...
2017: PloS One
https://www.readbyqxmd.com/read/28169306/graphene-copper-composite-with-micro-layered-grains-and-ultrahigh-strength
#13
Lidong Wang, Ziyue Yang, Ye Cui, Bing Wei, Shichong Xu, Jie Sheng, Miao Wang, Yunpeng Zhu, Weidong Fei
Graphene with ultrahigh intrinsic strength and excellent thermal physical properties has the potential to be used as the reinforcement of many kinds of composites. Here, we show that very high tensile strength can be obtained in the copper matrix composite reinforced by reduced graphene oxide (RGO) when micro-layered structure is achieved. RGO-Cu powder with micro-layered structure is fabricated from the reduction of the micro-layered graphene oxide (GO) and Cu(OH)2 composite sheets, and RGO-Cu composites are sintered by spark plasma sintering process...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28165269/analyzing-dyadic-data-with-multilevel-modeling-versus-structural-equation-modeling-a-tale-of-two-methods
#14
Thomas Ledermann, David A Kenny
Multilevel modeling (MLM) and structural equation modeling (SEM) are the dominant methods for the analysis of dyadic data. Both methods are extensively reviewed for the widely used actor-partner interdependence model and the dyadic growth curve model, as well as other less frequently adopted models, including the common fate model and the mutual influence model. For each method, we discuss the analysis of distinguishable and indistinguishable members, the treatment of missing data, the standardization of effects, and tests of mediation...
February 6, 2017: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/28128641/incongruent-perceptions-of-the-care-values-of-hospitalized-persons-with-dementia-a-pilot-study-of-patient-family-caregiver-dyads
#15
Lyndsey M Miller, Carol J Whitlatch, Christopher S Lee, Karen S Lyons
OBJECTIVE: Many difficult decisions are made in the inpatient hospital setting regarding the daily care of persons with dementia (PWDs). Incongruent perceptions of the PWD's care values limit the family caregiver's ability to make surrogate decisions. The objectives of this pilot study were to describe and identify determinants of incongruent perceptions in the hospital setting. METHODS: Using multilevel modeling (MLM), we examined cross-sectional data collected from 42 PWD-family caregiver dyads...
January 27, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28053503/assessment-of-ischemia-in-acute-central-retinal-vein-occlusion-from-inner-retinal-reflectivity-on-spectral-domain-optical-coherence-tomography
#16
David J Browning, Omar S Punjabi, Chong Lee
PURPOSE: To determine the relationship between different spectral domain optical coherence tomography (SD-OCT) signs of retinal ischemia in acute central retinal vein occlusion (CRVO) and whether they predict anterior segment neovascularization (ASNV). DESIGN: Retrospective, observational study. SUBJECTS: Thirty-nine consecutive patients with acute CRVO and 12 months of follow-up. METHODS: We graded baseline SD-OCTs for increased reflectivity of the inner retina, loss of definition of inner retinal layers, presence of a prominent middle-limiting membrane (p-MLM) sign, and presence of paracentral acute middle maculopathy (PAMM)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28017371/mixed-model-association-with-family-biased-case-control-ascertainment
#17
Tristan J Hayeck, Po-Ru Loh, Samuela Pollack, Alexander Gusev, Nick Patterson, Noah A Zaitlen, Alkes L Price
Mixed models have become the tool of choice for genetic association studies; however, standard mixed model methods may be poorly calibrated or underpowered under family sampling bias and/or case-control ascertainment. Previously, we introduced a liability threshold-based mixed model association statistic (LTMLM) to address case-control ascertainment in unrelated samples. Here, we consider family-biased case-control ascertainment, where case and control subjects are ascertained non-randomly with respect to family relatedness...
January 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27977845/stuck-in-limbo-motivational-antecedents-and-consequences-of-experiencing-action-crises-in-personal-goal-pursuit
#18
Anne C Holding, Nora H Hope, Brenda Harvey, Ariane S Marion Jetten, Richard Koestner
OBJECTIVE: Action crises describe the intrapsychic conflicts individuals experience when they feel torn between further goal pursuit and goal disengagement. The present investigation introduces autonomous and controlled motivation as independent predictors of action crisis severity, beyond known personality level predictors (action orientation), and novel personality level predictors (neuroticism and conscientiousness). METHOD: Using a multi-wave prospective longitudinal design and multilevel modeling (MLM) we followed students pursuing 3 personal goals across an academic semester (N = 425 undergraduates, 76% female, 57% Caucasian, Mage = 20...
December 15, 2016: Journal of Personality
https://www.readbyqxmd.com/read/27936303/using-multiple-group-modeling-to-test-moderators-in-meta-analysis
#19
Alexander M Schoemann
Meta-analysis is a popular and flexible analysis that can be fit in many modeling frameworks. Two methods of fitting meta-analyses that are growing in popularity are structural equation modeling (SEM) and multilevel modeling (MLM). By using SEM or MLM to fit a meta-analysis researchers have access to powerful techniques associated with SEM and MLM. This paper details how to use one such technique, multiple group analysis, to test categorical moderators in meta-analysis. In a multiple group meta-analysis a model is fit to each level of the moderator simultaneously...
December 2016: Research Synthesis Methods
https://www.readbyqxmd.com/read/27933004/policy-implications-of-achievement-testing-using-multilevel-models-the-case-of-brazilian-elementary-schools
#20
Igor G Menezes, Victor R Duran, Euclides J Mendonça Filho, Tainã J Veloso, Stella M S Sarmento, Christine L Paget, Kai Ruggeri
Large-scale educational assessment has been established as source of descriptive, evaluative and interpretative information that influence educational policies worldwide throughout the last third of the twentieth century. In the 1990s the Brazilian Ministry of Education developed the National Basic Education Assessment System (SAEB) that regularly measures management, resource and contextual school features and academic achievement in public and private institutions. In 2005, after significant piloting and review of the SAEB, a new sampling strategy was taken and Prova Brasil became the new instrument used by the Ministry to assess skills in Portuguese (reading comprehension) and Mathematics (problem solving), as well as collecting contextual information concerning the school, principal, teacher, and the students...
2016: Frontiers in Psychology
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