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https://www.readbyqxmd.com/read/27905018/minimal-excision-and-primary-suture-is-a-cost-efficient-definitive-treatment-for-pilonidal-disease-with-low-morbidity-a-population-based-interventional-and-a-cross-sectional-cohort-study
#1
Kaveh Khodakaram, Joachim Stark, Ida Höglund, Roland E Andersson
BACKGROUND: Conventional treatment of pilonidal disease with wide excision is associated with high morbidity. We describe the short- and long-term results and the impact on the health care system of a simple operation performed in the office under local anaesthesia, consisting of minimal excision of pilonidal sinuses with primary suture-the modified Lord-Millar operation (mLM). METHODS: All patients operated with mLM from February 2008 till November 2012 were prospectively followed for recurrence by telephone interviews and examination of symptomatic patients till July 2015...
November 30, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27902805/genome-wide-association-mapping-reveals-novel-qtl-for-seedling-leaf-rust-resistance-in-a-worldwide-collection-of-winter-wheat
#2
Genqiao Li, Xiangyang Xu, Guihua Bai, Brett F Carver, Robert Hunger, J Michael Bonman, James Kolmer, Hongxu Dong
Leaf rust of wheat ( L.) is a major disease that causes significant yield losses worldwide. The short-lived nature of leaf rust resistance () genes necessitates a continuous search for novel sources of resistance. We performed a genome-wide association study (GWAS) on a panel of 1596 wheat accessions. The panel was evaluated for leaf rust reaction by testing with a bulk of Eriks. () isolates collected from multiple fields of Oklahoma in 2013 and two predominant races in the fields of Oklahoma in 2015. The panel was genotyped with a set of 5011 single-nucleotide polymorphism (SNP) markers...
November 2016: Plant Genome
https://www.readbyqxmd.com/read/27898827/identification-of-genomic-loci-associated-with-the-photochemical-reflectance-index-by-genome-wide-association-study-in-soybean
#3
Matthew Herritt, Arun Prabhu Dhanapal, Felix B Fritschi
The photochemical reflectance index (PRI) is determined from canopy spectral reflectance measurements and can provide important information about photosynthesis. The PRI can be used to assess the epoxidation state of xanthophyll pigments, which provides information on nonphotochemical quenching (NPQ) and the amount of energy used for photosynthesis. Genome-wide association analyses were conducted to identify single-nucleotide polymorphisms (SNPs) and genomic loci associated with PRI using data from a soybean [ (L...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27885104/could-vitamin-c-and-zinc-chloride-protect-the-germ-cells-against-sodium-arsenite
#4
L S Altoé, I B Reis, Mlm Gomes, H Dolder, Jc Monteiro Pirovani
Arsenic (As) is commonly associated with natural and human processes such as volcanic emissions, mining and herbicides production, being an important pollutant. Several studies have associated As intake with male fertility reduction, thus the aim of the present study was to evaluate whether vitamin C and/or zinc would counteract As side effects within the testicles. Adult male Wistar rats were divided into six experimental groups: control, sodium arsenite (5 mg/kg/day), vitamin C (100 mg/kg/day), zinc chloride (ZnCl2; 20 mg/kg/day), sodium arsenite + vitamin C and sodium arsenite + ZnCl2 Testicles and epididymis were harvested and either frozen or routinely processed to be embedded in glycol methacrylate resin...
November 24, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27808356/genetic-divergence-through-joint-analysis-of-morphoagronomic-and-molecular-characters-in-accessions-of-jatropha-curcas
#5
C N Pestana-Caldas, S A Silva, E L Machado, D R de Souza, E C Cerqueira-Pereira, M S Silva
The aim of this study was to investigate the genetic divergence between accessions of Jatropha curcas through joint analysis of morphoagronomic and molecular characters. To this end, we investigated 11 morphoagronomic characters and performed molecular genotyping, using 23 inter-simple sequence repeat (ISSR) primers in 46 accessions of J. curcas. We calculated the contribution of each character on divergence using analysis of variance. The grouping among accessions was performed using the Ward-MLM (modified location model) method, using morphoagronomic and molecular data, whereas the cophenetic correlation was obtained based on Gower's algorithm...
October 5, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27803267/what-s-the-rush-tort-laws-and-elective-early-term-induction-of-labor
#6
Louise Marie Roth
Tort laws aim to deter risky medical practices and increase accountability for harm. This research examines their effects on deterrence of a high-risk obstetric practice in the United States: elective early-term (37-38 weeks gestation) induction of labor. Using birth certificate data from the Natality Detail Files and state-level data from publicly available sources, this study analyzes the effects of tort laws on labor induction with multilevel models (MLM) of 665,491 early-term births nested in states. Results reveal that caps on damages are associated with significantly higher odds of early-term induction and Proportionate Liability (PL) is associated with significantly lower odds compared to Joint and Several Liability (JSL)...
November 1, 2016: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/27756789/application-of-mice-humanised-for-cytochrome-p450-cyp2d6-to-the-study-of-tamoxifen-metabolism-and-drug-drug-interaction-with-antidepressants
#7
A Kenneth MacLeod, Lesley A McLaughlin, Colin J Henderson, C Roland Wolf
Tamoxifen is an oestrogen-receptor (ER) antagonist used in the treatment of breast cancer. It is a pro-drug, converted by several P450 enzymes to a primary metabolite, N-desmethyltamoxifen (NDT), which is then further modified by CYP2D6 to a pharmacologically potent secondary metabolite, 4-hydroxy-N-desmethyltamoxifen (endoxifen). Anti-depressants (ADs), which are often co-prescribed to patients receiving tamoxifen, are also metabolised by CYP2D6 and evidence suggests that a drug-drug interaction (DDI) between these agents adversely affects the outcome of tamoxifen therapy by inhibiting endoxifen formation...
October 18, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27751660/measuring-recovery-an-adapted-brief-assessment-of-mood-bam-compared-to-biochemical-and-power-output-alterations
#8
David A Shearer, William Sparkes, Jonny Northeast, Daniel J Cunningham, Christian J Cook, Liam P Kilduff
OBJECTIVES: Biochemical (e.g. creatine kinase (CK)) and neuromuscular (e.g. peak power output (PPO)) markers of recovery are expensive and require specialist equipment. Perceptual measures are an effective alternative, yet most validated scales are too long for daily use. DESIGN: This study utilises a longitudinal multi-level design to test an adapted Brief Assessment of Mood (BAM+), with four extra items and a 100mm visual analogue scale to measure recovery. METHODS: Elite under-21 academy soccer players (N=11) were monitored across five games with data (BAM+, CK and PPO) collected for each game at 24h pre, 24h and 48h post-match...
October 5, 2016: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/27700475/leadership-and-management-in-uk-medical-school-curricula
#9
Richard Jefferies, Ibrahim H N Sheriff, Jacob H Matthews, Olivia Jagger, Sarah Curtis, Peter Lees, Peter C Spurgeon, Daniel Mark Fountain
Purpose Although medical leadership and management (MLM) is increasingly being recognised as important to improving healthcare outcomes, little is understood about current training of medical students in MLM skills and behaviours in the UK. The paper aims to discuss these issues. Design/methodology/approach This qualitative study used validated structured interviews with expert faculty members from medical schools across the UK to ascertain MLM framework integration, teaching methods employed, evaluation methods and barriers to improvement...
October 10, 2016: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/27672353/anxiety-sensitivity-and-smoking-variability-among-treatment-seeking-smokers
#10
Mark B Powers, Michelle L Davis, Brooke Y Kauffman, Scarlett O Baird, Michael Zvolensky, David Rosenfield, Bess H Marcus, Timothy S Church, Georita Frierson, Michael W Otto, Jasper A J Smits
OBJECTIVES: Anxiety sensitivity (AS) is associated with poor smoking cessation outcomes. One reason may be that smokers with high AS smoke differently (i.e., to manage negative affect and uncomfortable bodily sensations) than other smokers, leading to stronger addiction (due to an affect/sensation based and thereby highly variable rather than a regular smoking routine). Thus, we examined the relationship between AS and smoking variability in a group of treatment-seeking smokers. METHODS: Participants (N = 136; 52...
September 2016: Addictive Disorders & Their Treatment
https://www.readbyqxmd.com/read/27634218/dna-methylation-profiling-of-esophageal-adenocarcinoma-using-methylation-ligation-dependent-macroarray-mlm
#11
Isabelle Guilleret, Lorena Losi, Sonia T Chelbi, Sergio Fonda, Stéphanie Bougel, Sara Saponaro, Gaia Gozzi, Loredana Alberti, Richard Braunschweig, Jean Benhattar
Most types of cancer cells are characterized by aberrant methylation of promoter genes. In this study, we described a rapid, reproducible, and relatively inexpensive approach allowing the detection of multiple human methylated promoter genes from many tissue samples, without the need of bisulfite conversion. The Methylation Ligation-dependent Macroarray (MLM), an array-based analysis, was designed in order to measure methylation levels of 58 genes previously described as putative biomarkers of cancer. The performance of the design was proven by screening the methylation profile of DNA from esophageal cell lines, as well as microdissected formalin-fixed and paraffin-embedded (FFPE) tissues from esophageal adenocarcinoma (EAC)...
October 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27617019/association-mapping-of-main-tomato-fruit-sugars-and-organic-acids
#12
Jiantao Zhao, Yao Xu, Qin Ding, Xinli Huang, Yating Zhang, Zhirong Zou, Mingjun Li, Lu Cui, Jing Zhang
Association mapping has been widely used to map the significant associated loci responsible for natural variation in complex traits and are valuable for crop improvement. Sugars and organic acids are the most important metabolites in tomato fruits. We used a collection of 174 tomato accessions composed of Solanum lycopersicum (123 accessions) and S. lycopersicum var cerasiforme (51 accessions) to detect significantly associated loci controlling the variation of main sugars and organic acids. The accessions were genotyped with 182 SSRs spreading over the tomato genome...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27576450/identification-of-favorable-snp-alleles-and-candidate-genes-for-traits-related-to-early-maturity-via-gwas-in-upland-cotton
#13
Junji Su, Chaoyou Pang, Hengling Wei, Libei Li, Bing Liang, Caixiang Wang, Meizhen Song, Hantao Wang, Shuqi Zhao, Xiaoyun Jia, Guangzhi Mao, Long Huang, Dandan Geng, Chengshe Wang, Shuli Fan, Shuxun Yu
BACKGROUND: Early maturity is one of the most important and complex agronomic traits in upland cotton (Gossypium hirsutum L). To dissect the genetic architecture of this agronomically important trait, a population consisting of 355 upland cotton germplasm accessions was genotyped using the specific-locus amplified fragment sequencing (SLAF-seq) approach, of which a subset of 185 lines representative of the diversity among the accessions was phenotypically characterized for six early maturity traits in four environments...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27552325/genome-wide-association-study-of-spot-form-of-net-blotch-resistance-in-the-upper-midwest-barley-breeding-programs
#14
R R Burlakoti, S Gyawali, S Chao, K P Smith, R D Horsley, B Cooper, G J Muehlbauer, S M Neate
Pyrenophora teres f. maculata, the causal agent of spot form of net blotch (SFNB), is an emerging pathogen of barley in the United States and Australia. Compared with net form of net blotch (NFNB), less is known in the U.S. Upper Midwest barley breeding programs about host resistance and quantitative trait loci (QTL) associated with SFNB in breeding lines. The main objective of this study was to identify QTL associated with SFNB resistance in the Upper Midwest two-rowed and six-rowed barley breeding programs using a genome-wide association study approach...
October 11, 2016: Phytopathology
https://www.readbyqxmd.com/read/27539563/adsorption-thermodynamics-of-two-domain-antifreeze-proteins-theory-and-monte-carlo-simulations
#15
Claudio F Narambuena, Fabricio O Sanchez Varretti, Antonio J Ramirez-Pastor
In this paper we develop the statistical thermodynamics of two-domain antifreeze proteins adsorbed on ice. We use a coarse-grained model and a lattice network in order to represent the protein and ice, respectively. The theory is obtained by combining the exact analytical expression for the partition function of non-interacting linear k-mers adsorbed in one dimension, and its extension to higher dimensions. The total and partial adsorption isotherms, and the coverage and temperature dependence of the Helmholtz free energy and configurational entropy are given...
September 21, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27525912/clustering-of-soybean-genotypes-via-ward-mlm-and-anns-associated-with-mixed-models
#16
P E Teodoro, F E Torres, A M Corrêa
The objectives of this study were to use mixed models to confirm the presence of genetic variability in 16 soybean genotypes, to compare clusters generated by artificial neural networks (ANNs) with those created by the Ward modified location model (MLM) technique, and to indicate parental combinations that hold promise for obtaining superior segregating populations of soybean. A field trial was conducted between November 2014 and February 2015 at Universidade Estadual de Mato Grosso do Sul, Aquidauana, MS. The experimental design consisted of four replications of randomized blocks, each containing 16 treatments...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27522648/genetic-variation-and-association-mapping-of-waterlogging-tolerance-in-chrysanthemum
#17
Jiangshuo Su, Fei Zhang, Pirui Li, Zhiyong Guan, Weimin Fang, Fadi Chen
Forty-five molecular markers were detected significantly associated with chrysanthemum' waterlogging tolerance, and four favorable parental lines were identified as potential donors for improving waterlogging tolerance in chrysanthemum. The productivity of chrysanthemum is downgraded by waterlogging soils, which has driven a search for germplasm showing an enhanced level of waterlogging tolerance (WT). As yet little is known regarding the mode of inheritance of WT in chrysanthemum. The study set out to characterize the extent of genetic variation for WT represented in a collection of one hundred chrysanthemum accessions by testing them under both greenhouse and field conditions...
December 2016: Planta
https://www.readbyqxmd.com/read/27512395/genome-wide-association-study-identifies-candidate-genes-for-starch-content-regulation-in-maize-kernels
#18
Na Liu, Yadong Xue, Zhanyong Guo, Weihua Li, Jihua Tang
Kernel starch content is an important trait in maize (Zea mays L.) as it accounts for 65-75% of the dry kernel weight and positively correlates with seed yield. A number of starch synthesis-related genes have been identified in maize in recent years. However, many loci underlying variation in starch content among maize inbred lines still remain to be identified. The current study is a genome-wide association study that used a set of 263 maize inbred lines. In this panel, the average kernel starch content was 66...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27500270/the-effect-of-mycophenolate-mofetil-on-early-wound-healing-in-a-rodent-model
#19
Martine Cm Willems, Thijs Hendriks, Roger Mlm Lomme, Ben M de Man, J Adam van der Vliet
BACKGROUND: Immunosuppressant agents are inevitable for solid organ recipients, but may have a negative effect on wound healing that is difficult to measure because of clinical use of a polydrug regime. The evidence on mycophenolate mofetil (MMF) is scarce and contradictory. This study aims to investigate the effect of MMF administration on wound healing. METHODS: Ninety-six male Wistar rats divided into 4 groups underwent anastomotic construction in ileum and colon at day 0...
June 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27491332/use-of-the-physical-environment-to-support-everyday-activities-for-people-with-dementia-a-systematic-review
#20
R Woodbridge, M P Sullivan, E Harding, S Crutch, K J Gilhooly, Mlm Gilhooly, A McIntyre, L Wilson
Difficulty with everyday activities is a key symptom and defining feature of dementia, relating to subjective reports of well-being and overall quality of life. One way to support individuals in their daily activities is by modifying the physical environment to make it easier to interact with during activity performance. This systematic review explores the range of studies available using physical environmental strategies to support performance in everyday activities for people with dementia. Seventy-two relevant studies were identified by the search...
August 4, 2016: Dementia
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