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https://www.readbyqxmd.com/read/29914353/genome-wide-mapping-of-quantitative-trait-loci-in-admixed-populations-using-mixed-linear-model-and-bayesian-multiple-regression-analysis
#1
Ali Toosi, Rohan L Fernando, Jack C M Dekkers
BACKGROUND: Population stratification and cryptic relationships have been the main sources of excessive false-positives and false-negatives in population-based association studies. Many methods have been developed to model these confounding factors and minimize their impact on the results of genome-wide association studies. In most of these methods, a two-stage approach is applied where: (1) methods are used to determine if there is a population structure in the sample dataset and (2) the effects of population structure are corrected either by modeling it or by running a separate analysis within each sub-population...
June 19, 2018: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/29901419/association-with-monoclonal-antibody-promotes-intracellular-delivery-of-lycopene
#2
Ivan M Petyaev, Naylia A Zigangirova, Valeriy V Tsibezov, Elena Y Morgunova, Natalia E Bondareva, Nigel H Kyle, Yuriy K Bashmakov
Incubation of B10.MLM cells, a cell line of alveolar macrophages, with lycopene, a carotenoid, leads to an increase of lycopene content in their microsomal fraction. That increase was higher and developed faster when the cells were incubated with immune complexes formed by lycopene and mAb 6B9 (L-6B9 mAb), a monoclonal hapten-specific antibody raised against lycopene, as compared with dimethyl sulfoxide (DMSO)-dissolved lycopene (DMSO-L). Moreover, incubation of B10.MLM cells with L-6B9 mAb complexes was accompanied by more efficient accumulation of lipid droplets in the cultured cells and more significant inhibition of mRNA for 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase, a rate-limiting enzyme of cholesterol biosynthesis known to be targeted by lycopene...
June 14, 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29899533/chronic-infection-with-mycobacterium-lepraemurium-induces-alterations-in-the-hippocampus-associated-with-memory-loss
#3
Enrique Becerril-Villanueva, María Dolores Ponce-Regalado, Gilberto Pérez-Sánchez, Alberto Salazar-Juárez, Rodrigo Arreola, María Elizbeth Álvarez-Sánchez, Mario Juárez-Ortega, Ramcés Falfán-Valencia, Rogelio Hernández-Pando, Jorge Morales-Montor, Lenin Pavón, Oscar Rojas-Espinosa
Murine leprosy, caused by Mycobacterium lepraemurium (MLM), is a chronic disease that closely resembles human leprosy. Even though this disease does not directly involve the nervous system, we investigated a possible effect on working memory during this chronic infection in Balb/c mice. We evaluated alterations in the dorsal region of the hippocampus and measured peripheral levels of cytokines at 40, 80, and 120 days post-infection. To evaluate working memory, we used the T-maze while a morphometric analysis was conducted in the hippocampus regions CA1, CA2, CA3, and dentate gyrus (DG) to measure morphological changes...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29896470/a-theory-based-contextual-nutrition-education-manual-enhanced-nutrition-teaching-skill
#4
Mojisola D Kupolati, Una E MacIntyre, Gerda J Gericke
Background: A theory-based contextual nutrition education manual (NEM) may enhance effective teaching of nutrition in schools. School nutrition education should lead to the realization of such benefits as improved health, scholarly achievement leading to manpower development and consequently the nation's development. The purpose of the study was to develop a contextual NEM for teachers of Grade 5 and 6 learners in the Bronkhorstspruit district, South Africa, and to assess teachers' perception on the use of the manual for teaching nutrition...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29882921/distinct-dna-methylation-profiles-in-ovarian-tumors-opportunities-for-novel-biomarkers
#5
Lorena Losi, Sergio Fonda, Sara Saponaro, Sonia T Chelbi, Cesare Lancellotti, Gaia Gozzi, Loredana Alberti, Luca Fabbiani, Laura Botticelli, Jean Benhattar
Aberrant methylation of multiple promoter CpG islands could be related to the biology of ovarian tumors and its determination could help to improve treatment strategies. DNA methylation profiling was performed using the Methylation Ligation-dependent Macroarray (MLM), an array-based analysis. Promoter regions of 41 genes were analyzed in 102 ovarian tumors and 17 normal ovarian samples. An average of 29% of hypermethylated promoter genes was observed in normal ovarian tissues. This percentage increased slightly in serous, endometrioid, and mucinous carcinomas (32%, 34%, and 45%, respectively), but decreased in germ cell tumors (20%)...
May 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29809021/trajectories-of-marital-parent-child-and-sibling-conflict-during-pediatric-cancer-treatment
#6
Lynn Fainsilber Katz, Kaitlyn Fladeboe, Iris Lavi, Kevin King, Joy Kawamura, Debra Friedman, Bruce Compas, David Breiger, Liliana Lengua, Kyrill Gurtovenko, Nicole Stettler
OBJECTIVE: The stress of having a child with cancer can impact the quality of relationships within the family. The current study describes the longitudinal trajectory of marital, parent-child, and sibling conflict beginning around the time of diagnosis through the first year of treatment. We examined the average level of marital, parent-child, and sibling conflict at each monthly time point in the first year of treatment; the proportion of families that fall into the distressed range of marital, parent-child, and sibling conflict at each time point; the typical trajectory of conflict during the first year of treatment and whether there are differences in trajectories across families...
May 28, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29786528/modelling-correlated-data-multilevel-models-and-generalized-estimating-equations-and-their-use-with-data-from-research-in-developmental-disabilities
#7
Dimitrios Vagenas, Vasiliki Totsika
BACKGROUND: The use of Multilevel Models (MLM) and Generalized Estimating Equations (GEE) for analysing clustered data in the field of intellectual and developmental disability (IDD) research is still limited. METHOD: We present some important features of MLMs and GEEs: main function, assumptions, model specification and estimators, sample size and power. We provide an overview of the ways MLMs and GEEs have been used in IDD research. RESULTS: While MLMs and GEEs are both appropriate for longitudinal and/or clustered data, they differ in the assumptions they impose on the data, and the inferences made...
May 18, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29779808/is-multi-level-marketing-of-nutrition-supplements-a-legal-and-an-ethical-practice
#8
Diana Cardenas, Vanessa Fuchs-Tarlovsky
BACKGROUND: Multi-level marketing (MLM) of nutrition products has experienced dramatic growth in recent decades. 'Wellness' is the second most popular niche in the MLM industry and represents 35% of sales among all the products in 2016. This category includes dietary supplements, weight management and sports nutrition products. The aim of this paper is to analyse whether this practice is legal and ethical. METHODS: An analysis of available documentary information about the legal aspects of Multi-level marketing business was performed...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29758023/genetic-variability-in-brazilian-capsicum-baccatum-germplasm-collection-assessed-by-morphological-fruit-traits-and-aflp-markers
#9
Rafaella Cardoso, Claudete F Ruas, Renata M Giacomin, Paulo M Ruas, Eduardo A Ruas, Rosa L Barbieri, Rosana Rodrigues, Leandro S A Gonçalves
Capsicum baccatum is one of the main pepper species grown and consumed in South America. In Brazil, it is commonly cultivated by family farmers, using mostly the genotypes bishop's hat genotypes (locally cambuci) and red chili pepper (dedo-de-moça). This study had the objective of characterizing 116 C. baccatum accessions from different regions of Brazil, based on morphological fruit descriptors and AFLP (Amplified Fragment Length Polymorphisms) markers. Broad phenotypic variability among the C. baccatum accessions was detected when using morphological fruit descriptors...
2018: PloS One
https://www.readbyqxmd.com/read/29726600/activity-oriented-teaching-of-stochastics-in-elementary-school
#10
Ulrike Kipman, Anton Kühberger, Belinda Pletzer
BACKGROUND: There is little research on how to best introduce children to stochastics. In general, demonstration and concrete experience seem to be necessary to establish good understanding of stochastics in children. Pupils seem to be able to develop an intuition on stochastic thinking when they actively solve probabilistic problems and carry out probability experiments based on age-adequate content and materials. AIMS: This study investigates how activity-oriented education can improve stochastics achievement of children...
May 4, 2018: British Journal of Educational Psychology
https://www.readbyqxmd.com/read/29726456/achieving-interoperability-between-arden-syntax-based-clinical-decision-support-and-openehr-based-data-systems
#11
Martin Spineth, Andrea Rappelsberger, Klaus-Peter Adlassnig
BACKGROUND: Arden Syntax is an international standard for medical knowledge representation and processing. The openEHR Foundation publishes specifications for the creation of electronic health records based on interoperable data models. OBJECTIVES: To perform a feasibility study showing how Arden Syntax medical logic modules (MLMs) can access openEHR data. METHODS: Medexter's ArdenSuite was applied as an implementation of an Arden-Syntax-based clinical decision support framework, and Marand's EhrScape as an implementation of an openEHR system, for the purpose of data exchange...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29714825/multi-center-retrospective-study-of-the-prognosis-and-treatment-outcomes-of-japanese-oral-squamous-cell-carcinoma-patients-with-single-lymph-node-metastasis-and-extra-nodal-extension
#12
Takumi Hasegawa, Souichi Yanamoto, Mitsunobu Otsuru, Yasumasa Kakei, Masaya Okura, Nobuhiro Yamakawa, Shin-Ichi Yamada, Yoshihide Ota, Masahiro Umeda, Tadaaki Kirita, Hiroshi Kurita, Michihiro Ueda, Takahide Komori
BACKGROUND: Oral squamous cell carcinoma (OSCC) containing single lymph node metastasis (pN1) with extra nodal extension (ENE) is a rare clinical situation. Therefore, it is unclear whether pN1 with ENE is at high risk of recurrence among the OSCC population, or whether postoperative radiotherapy (RT)/concomitant chemoradiotherapy (CCRT) is effective in these cases. OBJECTIVES: The purpose of this retrospective study was to investigate the prognosis and compare between no postoperative therapy and postoperative RT/CCRT in pN1 with ENE OSCC patients...
May 1, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29713582/association-analysis-of-drought-tolerance-in-cut-chrysanthemum-chrysanthemum-morifolium-ramat-at-seedling-stage
#13
Pirui Li, Jiangshuo Su, Zhiyong Guan, Weimin Fang, Fadi Chen, Fei Zhang
Understanding the genetic architecture is a prerequisite for crop improvement. The current research aimed to characterize the extent of genetic variation of drought tolerance harbored in a global collection of 159 chrysanthemum cultivars over 2 years. An average subordinate function value (ASFV), integrating the wilting index, the fresh weight retention rate, and the survival rate after re-watering under two drought-stressed trials, was used to quantify the level of drought tolerance. The performance of ASFV was generally correlated between the 2 years; and a high magnitude (0...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29704124/growth-and-cell-properties-of-modified-lactobacillus-plantarum-cicc21001-with-supplementing-c-18-ffas-to-growth-medium-in-vitro
#14
Qinke Shen, Yuxian Wang, Jian Shen, Ling Jiang, Ce Wei, Hongman Zhang
Fatty acids (FAs) are one of the important factors that can influence cell growth and membrane composition. The aim of this study was to investigate the influence of supplementing MLM+ growth medium with C18 free fatty acids (C18 -FFAs), including stearic (C18:0), oleic (C18:1), linoleic (C18:2), and linolenic (C18:3) acid, on the growth of Lactobacillus plantarum CICC21001 by forming ion pairs with lysine to increase the solubility of FAs in liquid medium. The utilization of C18 -FFAs was further confirmed by GC-FID...
April 27, 2018: Current Microbiology
https://www.readbyqxmd.com/read/29678046/generalizing-the-arden-syntax-to-a-common-clinical-application-language
#15
Stefan Kraus
The Arden Syntax for Medical Logic Systems is a standard for encoding and sharing knowledge in the form of Medical Logic Modules (MLMs). Although the Arden Syntax has been designed to meet the requirements of data-driven clinical event monitoring, multiple studies suggest that its language constructs may be suitable for use outside the intended application area and even as a common clinical application language. Such a broader context, however, requires to reconsider some language features. The purpose of this paper is to outline the related modifications on the basis of a generalized Arden Syntax version...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29652848/excellent-tribological-properties-of-lower-reduced-graphene-oxide-content-copper-composite-by-using-a-one-step-reduction-molecular-level-mixing-process
#16
Haibin Nie, Licai Fu, Jiajun Zhu, Wulin Yang, Deyi Li, Lingping Zhou
Reduced graphene oxide (RGO) composite copper matrix powders were fabricated successfully by using a modified molecular-level mixing (MLM) method. Divalent copper ions (Cu2+ ) were adsorbed in oxygen functional groups of graphene oxide (GO) as a precursor, then were reduced simultaneously by one step chemical reduction. RGO showed a distribution converting from a random to a three-dimensional network in the copper matrix when its content increased to above 1.0 wt.% The tribological tests indicated that the friction coefficient of the composite with 1...
April 13, 2018: Materials
https://www.readbyqxmd.com/read/29616069/association-study-reveals-novel-genes-related-to-yield-and-quality-of-fruit-in-cape-gooseberry-physalis-peruviana-l
#17
Francy L García-Arias, Jaime A Osorio-Guarín, Victor M Núñez Zarantes
Association mapping has been proposed as an efficient approach to assist plant breeding programs to investigate the genetic basis of agronomic traits. In this study, we evaluated 18 traits related to yield, (FWP, NF, FWI, and FWII), fruit size-shape (FP, FA, MW, WMH, MH, HMW, DI, FSI, FSII, OVO, OBO), and fruit quality (FIR, CF, and SST), in a diverse collection of 100 accessions of Physalis peruviana including wild, landraces, and anther culture derived lines. We identified seven accessions with suitable traits: fruit weight per plant (FWP) > 7,000 g/plant and cracked fruits (CF) < 4%, to be used as parents in cape gooseberry breeding program...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29558166/virtual-levels-and-role-models-n-level-structural-equations-model-of-reciprocal-ratings-data
#18
Paras D Mehta
A general latent variable modeling framework called n-Level Structural Equations Modeling (NL-SEM) for dependent data-structures is introduced. NL-SEM is applicable to a wide range of complex multilevel data-structures (e.g., cross-classified, switching membership, etc.). Reciprocal dyadic ratings obtained in round-robin design involve complex set of dependencies that cannot be modeled within Multilevel Modeling (MLM) or Structural Equations Modeling (SEM) frameworks. The Social Relations Model (SRM) for round robin data is used as an example to illustrate key aspects of the NL-SEM framework...
May 2018: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/29541660/uplc-ms-ms-data-of-testosterone-metabolites-in-human-and-zebrafish-liver-microsomes-and-whole-zebrafish-larval-microsomes
#19
Moayad Saad, Sebastiaan Bijttebier, An Matheeussen, Evy Verbueken, Casper Pype, Christophe Casteleyn, Chris Van Ginneken, Louis Maes, Paul Cos, Steven Van Cruchten
This article represents data regarding a study published in Toxicology in vitro entitled " in vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds" (Saad et al., 2017) [1]. Data were acquired with ultra-performance liquid chromatography - accurate mass mass spectrometry (UPLC-amMS). A full spectrum scan was conducted for the testosterone (TST) metabolites from the microsomal stability assay in zebrafish and humans. The microsomal proteins were extracted from adult zebrafish male (MLM) and female (FLM) livers, whole body homogenates of 96 h post fertilization larvae (EM) and a pool of human liver microsomes from 50 donors (HLM)...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29525212/the-effect-of-high-fidelity-simulators-on-knowledge-retention-and-skill-self-efficacy-in-pediatric-advanced-life-support-courses-in-a-rural-state
#20
Stacy M Stellflug, Nancy K Lowe
PURPOSE: Rural health care providers (HCPs) care for millions of Americans despite challenges. Pediatric Advanced Life Support (PALS) provides rural HCPs training in assessment and interventions for critically ill/injured pediatric patients (American Heart Association, 2015). The purpose of this study was to determine the effects of integration of high fidelity simulators into PALS courses in a rural setting. DESIGN AND METHODS: Participants were randomized by course to control or experimental PALS conditions where the control group received PALS with low fidelity static manikins (LFM) and the experimental group received PALS with high-fidelity simulators (HFS)...
March 2018: Journal of Pediatric Nursing
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