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Stefan Kraus
The Arden Syntax for Medical Logic Systems is a standard for encoding and sharing knowledge in the form of Medical Logic Modules (MLMs). Although the Arden Syntax has been designed to meet the requirements of data-driven clinical event monitoring, multiple studies suggest that its language constructs may be suitable for use outside the intended application area and even as a common clinical application language. Such a broader context, however, requires to reconsider some language features. The purpose of this paper is to outline the related modifications on the basis of a generalized Arden Syntax version...
2018: Studies in Health Technology and Informatics
Haibin Nie, Licai Fu, Jiajun Zhu, Wulin Yang, Deyi Li, Lingping Zhou
Reduced graphene oxide (RGO) composite copper matrix powders were fabricated successfully by using a modified molecular-level mixing (MLM) method. Divalent copper ions (Cu2+ ) were adsorbed in oxygen functional groups of graphene oxide (GO) as a precursor, then were reduced simultaneously by one step chemical reduction. RGO showed a distribution converting from a random to a three-dimensional network in the copper matrix when its content increased to above 1.0 wt.% The tribological tests indicated that the friction coefficient of the composite with 1...
April 13, 2018: Materials
Francy L García-Arias, Jaime A Osorio-Guarín, Victor M Núñez Zarantes
Association mapping has been proposed as an efficient approach to assist plant breeding programs to investigate the genetic basis of agronomic traits. In this study, we evaluated 18 traits related to yield, (FWP, NF, FWI, and FWII), fruit size-shape (FP, FA, MW, WMH, MH, HMW, DI, FSI, FSII, OVO, OBO), and fruit quality (FIR, CF, and SST), in a diverse collection of 100 accessions of Physalis peruviana including wild, landraces, and anther culture derived lines. We identified seven accessions with suitable traits: fruit weight per plant (FWP) > 7,000 g/plant and cracked fruits (CF) < 4%, to be used as parents in cape gooseberry breeding program...
2018: Frontiers in Plant Science
Paras D Mehta
A general latent variable modeling framework called n-Level Structural Equations Modeling (NL-SEM) for dependent data-structures is introduced. NL-SEM is applicable to a wide range of complex multilevel data-structures (e.g., cross-classified, switching membership, etc.). Reciprocal dyadic ratings obtained in round-robin design involve complex set of dependencies that cannot be modeled within Multilevel Modeling (MLM) or Structural Equations Modeling (SEM) frameworks. The Social Relations Model (SRM) for round robin data is used as an example to illustrate key aspects of the NL-SEM framework...
March 20, 2018: Multivariate Behavioral Research
Moayad Saad, Sebastiaan Bijttebier, An Matheeussen, Evy Verbueken, Casper Pype, Christophe Casteleyn, Chris Van Ginneken, Louis Maes, Paul Cos, Steven Van Cruchten
This article represents data regarding a study published in Toxicology in vitro entitled " in vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds" (Saad et al., 2017) [1]. Data were acquired with ultra-performance liquid chromatography - accurate mass mass spectrometry (UPLC-amMS). A full spectrum scan was conducted for the testosterone (TST) metabolites from the microsomal stability assay in zebrafish and humans. The microsomal proteins were extracted from adult zebrafish male (MLM) and female (FLM) livers, whole body homogenates of 96 h post fertilization larvae (EM) and a pool of human liver microsomes from 50 donors (HLM)...
February 2018: Data in Brief
Stacy M Stellflug, Nancy K Lowe
PURPOSE: Rural health care providers (HCPs) care for millions of Americans despite challenges. Pediatric Advanced Life Support (PALS) provides rural HCPs training in assessment and interventions for critically ill/injured pediatric patients (American Heart Association, 2015). The purpose of this study was to determine the effects of integration of high fidelity simulators into PALS courses in a rural setting. DESIGN AND METHODS: Participants were randomized by course to control or experimental PALS conditions where the control group received PALS with low fidelity static manikins (LFM) and the experimental group received PALS with high-fidelity simulators (HFS)...
March 2018: Journal of Pediatric Nursing
Sayali S Phatak, Mohammad T Freigoun, César A Martín, Daniel E Rivera, Elizabeth V Korinek, Marc A Adams, Matthew P Buman, Predrag Klasnja, Eric B Hekler
BACKGROUND: Control systems engineering methods, particularly, system identification (system ID), offer an idiographic (i.e., person-specific) approach to develop dynamic models of physical activity (PA) that can be used to personalize interventions in a systematic, scalable way. The purpose of this work is to: 1) apply system ID to develop individual dynamical models of PA (steps/day measured using Fitbit Zip) in the context of a goal setting and positive reinforcement intervention informed by Social Cognitive Theory; and 2) compare insights on potential tailoring variables (i...
January 31, 2018: Journal of Biomedical Informatics
Yee-Ying Lee, Teck-Kim Tang, Eng-Tong Phuah, Nur Azwani Abdul Karim, Noorjahan Banu Mohamed Alitheen, Chin-Ping Tan, Intan Shameha Abdul Razak, Oi-Ming Lai
Medium-and-Long Chain Triacylglycerol (MLCT) is a type of structured lipid that is made up of medium chain, MCFA (C8-C12) and long chain, LCFA (C16-C22) fatty acid. Studies claimed that consumption of MLCT has the potential in reducing visceral fat accumulation as compared to long chain triacylglycerol, LCT. This is mainly attributed to the rapid metabolism of MCFA as compared to LCFA. Our study was designed to compare the anti-obesity effects of a enzymatically interesterified MLCT (E-MLCT) with physical blend of palm kernel and palm oil (B-PKOPO) having similar fatty acid composition and a commercial MLCT (C-MLCT) made of rapeseed/soybean oil on Diet Induced Obesity (DIO) C57BL/6J mice for a period of four months in low fat, LF (7%) and high fat, HF (30%) diet...
January 2018: Food Research International
Elaina Sabatine, Melissa Lippold, Kirsten Kainz
Parent and school bonds are protective against delinquency. This study used longitudinal data and multilevel Poisson regression models (MLM) to examine unique and interactive associations of parent and school bonds on youth delinquency in a sample of rural adolescents ( n = 945; 84% White). We investigated whether youth sex or transitioning to a new middle school moderated the linkages between parent and school bonds and later delinquency. Results indicated reduced delinquency was associated with positive parent and school relationships...
November 2017: Journal of Applied Developmental Psychology
Clarissa M E Richardson, Kenneth G Rice, Eric M Sauer, Kristin E Roberts
OBJECTIVE: Given the psychological issues experienced by individuals high in perfectionistic concerns (maladaptive perfectionism), or a feeling as if one is never good enough, and discrepancies in the literature as to whether these individuals experience benefits from therapy, it is imperative that research examine whether perfectionism actually improves throughout therapy. The current study improves upon past research by examining changes in perfectionism (both perfectionistic concerns and strivings) throughout therapy, rather than simply measuring perfectionism at pre- and post-therapy...
December 13, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
Hannah I Volpert-Esmond, Edgar C Merkle, Meredith P Levsen, Tiffany A Ito, Bruce D Bartholow
EEG data, and specifically the ERP, provide psychologists with the power to examine quickly occurring cognitive processes at the native temporal resolution at which they occur. Despite the advantages conferred by ERPs to examine processes at different points in time, ERP researchers commonly ignore the trial-to-trial temporal dimension by collapsing across trials of similar types (i.e., the signal averaging approach) because of constraints imposed by repeated measures ANOVA. Here, we present the advantages of using multilevel modeling (MLM) to examine trial-level data to investigate change in neurocognitive processes across the course of an experiment...
December 11, 2017: Psychophysiology
Xiao-Ming Zheng, Tingting Gong, Hong-Ling Ou, Dayuan Xue, Weihua Qiao, Junrui Wang, Sha Liu, Qingwen Yang, Kenneth M Olsen
Seed size is variable within many plant species, and understanding the underlying genetic factors can provide insights into mechanisms of local environmental adaptation. Here we make use of the abundant genomic and germplasm resources available for rice (Oryza sativa) to perform a large-scale genome-wide association study (GWAS) of grain width. Grain width varies widely within the crop and is also known to show climate-associated variation across populations of its wild progenitor. Using a filtered dataset of >1...
December 1, 2017: Genome Génome / Conseil National de Recherches Canada
Juan Ignacio Lopez Ortiz, Paola Torres, Evelina Quiroga, Claudio F Narambuena, Antonio J Ramirez-Pastor
In the present work, the adsorption of three-domain antifreeze proteins on ice is studied by combining a statistical thermodynamics based theory and Monte Carlo simulations. The three-domain protein is modeled by a trimer, and the ice surface is represented by a lattice of adsorption sites. The statistical theory, obtained from the exact partition function of non-interacting trimers adsorbed in one dimension and its extension to two dimensions, includes the configuration of the molecule in the adsorbed state, and allows the existence of multiple adsorption states for the protein...
November 29, 2017: Physical Chemistry Chemical Physics: PCCP
Sarah R Black, Matthew D Lerner, Elizabeth A Shirtcliff, Daniel N Klein
Previous investigations have explored stress and pubertal hormones in parallel; it has been a recent development, however, to explore the relationships between different hormones during puberty, and how this hormonal cross-talk may be influenced by the environment. The current study investigated neuroendocrine coupling, or the extent to which hormones are correlated within the individual, and also investigated early life stressors that may influence coupling. Participants were 405 adrenarcheal children (mean Tanner stage=1...
February 2018: Biological Psychology
Li-Sheng Hsu, Chien-Wei Chen, Chia-Hao Chang, Chien-Han Liao, Sheng-Lung Hsu, Wei-Ming Lin
Computed tomography (CT)-guided lung biopsy of nodules located near the heart may be associated with potential complications. To understand the influences of cardiac motion on lung parenchyma during biopsy, we processed the cardiac phase images of coronary CT angiography (CCTA) and noticed shifts in mediastinum lung margin (MLM) at different zones.Thirty eight CCTA (27 men and 11 women) were retrospectively evaluated. Image processing was done with Fiji (an open source Java image processing program by Fiji contributors) using 10% to 90% phase images of CCTA; and tissue displacement (MLM shift) was shown on the resulting images...
November 2017: Medicine (Baltimore)
Alisher A Abdullaev, Ilkhom B Salakhutdinov, Sharof S Egamberdiev, Ernest E Khurshut, Sofiya M Rizaeva, Mauricio Ulloa, Ibrokhim Y Abdurakhmonov
Limited polymorphism and narrow genetic base, due to genetic bottleneck through historic domestication, highlight a need for comprehensive characterization and utilization of existing genetic diversity in cotton germplasm collections. In this study, 288 worldwide Gossypium barbadense L. cotton germplasm accessions were evaluated in two diverse environments (Uzbekistan and USA). These accessions were assessed for genetic diversity, population structure, linkage disequilibrium (LD), and LD-based association mapping (AM) of fiber quality traits using 108 genome-wide simple sequence repeat (SSR) markers...
2017: PloS One
Lijun Meng, Baoxiang Wang, Xiangqian Zhao, Kimberly Ponce, Qian Qian, Guoyou Ye
Excessive amounts of metal are toxic and severely affect plant growth and development. Understanding the genetic control of metal tolerance is crucial to improve rice resistance to Fe, Zn, and Al toxicity. The multi-parent advanced generation inter-cross (MAGIC) populations were genotyped using a 55 K rice SNP array and screened at the seedling stage for Fe, Zn, and Al toxicity using a hydroponics system. Association analysis was conducted by implementing a mixed linear model (MLM) for each of the five MAGIC populations double cross DC1 (founders were SAGC-08, HHZ5-SAL9-Y3-Y1, BP1976B-2-3-7-TB-1-1, PR33282-B-8-1-1-1-1-1), double cross DC2 (founders of double cross were FFZ1, CT 16658-5-2-2SR-2-3-6MP, IR 68, IR 02A127), eight parents population 8way (founders were SAGC-08, HHZ5-SAL9-Y3-Y1, BP1976B-2-3-7-TB-1-1, PR33282-B-8-1-1-1-1-1, FFZ1, CT 16658-5-2-2SR-2-3-6MP, IR 68, IR 02A127), DC12 (DC1+DC2) and rice multi-parent recombinant inbred line population RMPRIL (DC1+DC2+8way)...
2017: Frontiers in Plant Science
Nicolas Haverkamp, André Beauducel
We investigated the effects of violations of the sphericity assumption on Type I error rates for different methodical approaches of repeated measures analysis using a simulation approach. In contrast to previous simulation studies on this topic, up to nine measurement occasions were considered. Effects of the level of inter-correlations between measurement occasions on Type I error rates were considered for the first time. Two populations with non-violation of the sphericity assumption, one with uncorrelated measurement occasions and one with moderately correlated measurement occasions, were generated...
2017: Frontiers in Psychology
Thomas P Stratton, Alexander L Perryman, Catherine Vilchèze, Riccardo Russo, Shao-Gang Li, Jimmy S Patel, Eric Singleton, Sean Ekins, Nancy Connell, William R Jacobs, Joel S Freundlich
We present the first prospective application of our mouse liver microsomal (MLM) stability Bayesian model. CD117, an antitubercular thienopyrimidine tool compound that suffers from metabolic instability (MLM t 1/2 < 1 min), was utilized to assess the predictive power of our new MLM stability model. The S-substituent was removed, a set of commercial reagents was utilized to construct a virtual library of 411 analogues, and our MLM stability model was applied to prioritize 13 analogues for synthesis and biological profiling...
October 12, 2017: ACS Medicinal Chemistry Letters
Kyoung Chul Park, Changwon Seo, Gajendra Gupta, Jeongyong Kim, Chang Yeon Lee
Designing and synthesizing the ordered light-harvesting systems, possessing complementary absorption and energy-transfer process between the chromophores, are essential steps to accomplish successful mimicking of the natural photosynthetic systems. Metal-organic frameworks (MOFs) can be considered as an ideal system to achieve this due to their highly ordered structure, superior synthetic versatility, and tailorable functionality. Herein, we have synthesized the new light-harvesting mixed-ligand MOFs (MLMs, MLM-1-3) via solvothermal reactions between a Zr6 cluster and a mixture of appropriate ratio of 1,3,6,8-tetrakis(p-benzoic acid)pyrene and [5,10,15,20-tetrakis(4-carboxy-phenyl)porphyrinato]-Zn(II) ligands...
November 8, 2017: ACS Applied Materials & Interfaces
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