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https://www.readbyqxmd.com/read/28550782/immunofluorescence-evaluation-of-4-hydroxynonenal-and-8-hydroxy-2-deoxyguanosine-activation-in-zebrafish-daino-rerio-larvae-brain-exposed-microinjected-to-propyl-gallate
#1
Ahmet Topal, Selim Çomakli, Mustafa Özkaraca, Alper Baran, Mine Köktürk, Veysel Parlak, Yavuz Selim Sağlam, Muhammed Atamanalp, Saltuk Buğrahan Ceyhun
Propyl gallate (PG) is a chemical compound obtained by esterification of propanol with gallic acid. Due to its antioxidative properties, it is widely used in cosmetics and pharmaceutical industries as well as to protect the oils in foods such as butter, milk-based desserts, chewing gum, mayonnaise, meat, soups, cereals, spices and seasonings from rancidity. This study has been designed to assessment 8-OHdG and 4-HNE activity, and histopathological changes in the brain tissues of zebrafish larvae, which is a lecithotrophic organism, after 96 h of PG exposure via microinjecting to yolk sac of embryo...
May 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28549948/microneedles-in-the-clinic
#2
REVIEW
Shubhmita Bhatnagar, Kaushalkumar Dave, Venkata Vamsi Krishna Venuganti
In general, there is a profound influence of reducing physical dimensions of particulates and devices on their physico-chemical and biological properties, and their performance. Reduction in the dimensions of hypodermic needle to micron-scale size has gained tremendous interest among researchers. Research efforts and publications investigating the design, development and applications of microneedles have exponentially increased in the recent years. Especially, microneedles have been widely studied and developed for cosmetic and therapeutic applications...
May 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28549762/assessment-of-exposure-for-baby-cosmetic-care-products-in-a-korean-population
#3
Eunyoung Lee, Jongbok Yun, Jaehyoun Ha, Byung Cheol Park, Gyeong Hun Park, Hak Rim Kim, Seung Phil Hong, Kyu Bong Kim, Myung Hwa Kim
Assessment of exposure to cosmetic products via the skin is important for evaluating the risks associated with the use of these products. However, few exposure studies have been conducted with babies, particularly in Asia. The aim of our study was to assess the exposure to selected cosmetic products in babies under the age of 36 months, over both winter and summer months. We evaluated exposure for seven cosmetic baby care products identified in a previous web-based survey as being commonly used by Korean parents...
May 23, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28549404/the-impact-of-quercetin-on-wound-healing-relates-to-changes-in-%C3%AE-v-and-%C3%AE-1-integrin-expression
#4
Karen M Doersch, M Karen Newell-Rogers
Overly fibrotic wound healing can lead to excess scar formation, causing functional impairment and undesirable cosmetic results. However, there are few successful treatments available to prevent or remediate scars. This study sought to explore the molecular mechanisms by which quercetin, a naturally-occurring antifibrotic agent, diminishes scar formation. Using both mice and fibroblast cells, we examined quercetin's impact on fibrosis and the wound healing rate, and potential molecular mechanisms underlying the quercetin-mediated reduction of fibrosis...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28549044/a-modified-suction-assisted-technique-of-transfer-of-diced-cartilage-graft-to-carrier-material-and-outcome-of-direct-injection-of-unwrapped-diced-cartilage-in-rhinoplasty
#5
Muhammad Mustehsan Bashir, Muhammad Sohail, Farid Ahmad Khan, Sadia Nosheen Jan, Hamid Hussain Ansari, Umer Nazir, Zohaib Hidayat
OBJECTIVE: To describe a modified suction-assisted technique (MSAT) of transfer of diced cartilage (DC) graft to a carrier material and to determine the clinical outcome of direct injection of unwrapped diced cartilage (UDC) in rhinoplasty. PLACE AND DURATION OF STUDY: Department of Plastic Surgery, KEMU, Mayo Hospital, Lahore from February 2011 to January 2015 METHODS:: Forty-seven patients of both genders with types 0 to 3 saddle nose deformity were included. Patients with types 4 and 5 saddle nose deformity, diabetes, hypertension, hepatic or renal disorders were excluded...
May 25, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28548971/allergic-contact-dermatitis-in-preservatives-current-standing-and-future-options
#6
Gustavo Deza, Ana M Giménez-Arnau
PURPOSE OF REVIEW: Preservatives are well known skin sensitizers and represent one of the main causes of contact allergy. The purpose of this article is to review the current state of contact sensitization induced by preservatives and point future alternatives for products' preservation. RECENT FINDINGS: Isothiazolinones currently are the most common preservatives responsible of contact allergy in Europe and in the United States, and although some regulatory interventions have been taken place, the current contact allergy outbreak is not yet under control...
May 25, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28547293/nonsurgical-facial-rejuvenation-outcomes-and-safety-of-neuromodulator-and-soft-tissue-filler-procedures-performed-in-a-resident-cosmetic-clinic
#7
Ali A Qureshi, Rajiv P Parikh, Ketan Sharma, Terence M Myckatyn, Marissa M Tenenbaum
BACKGROUND: The ability to perform nonsurgical facial rejuvenation procedures is a core competency requirement for plastic surgery residents. However, limited data exist on training models to achieve competency in nonsurgical facial rejuvenation and on outcomes of these procedures performed by residents. The purpose here is to evaluate patient-reported outcomes and safety of nonsurgical facial rejuvenation procedures performed by plastic surgery residents. METHODS: We prospectively enrolled 50 patients undergoing neuromodulator and/or soft-tissue filler injections in a resident cosmetic clinic between April and August 2016...
May 25, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28544967/novel-glycosylated-mycosporine-like-amino-acid-13-o-%C3%AE-galactosyl-porphyra-334-from-the-edible-cyanobacterium-nostoc-sphaericum-protective-activity-on-human-keratinocytes-from-uv-light
#8
Kenji Ishihara, Ryuichi Watanabe, Hajime Uchida, Toshiyuki Suzuki, Michiaki Yamashita, Hiroyuki Takenaka, Ehsan Nazifi, Seiichi Matsugo, Minami Yamaba, Toshio Sakamoto
A UV-absorbing compound was purified and identified as a novel glycosylated mycosporine-like amino acid (MAA), 13-O-β-galactosyl-porphyra-334 (β-Gal-P334) from the edible cyanobacterium Nostoc sphaericum, known as "ge xian mi" in China and "cushuro" in Peru. Occurrence of the hexosylated derivative of shinorine (hexosyl-shinorine) was also supported by LC-MS/MS analysis. β-Gal-P334 accounted for about 86.5% of total MAA in N. sphaericum, followed by hexosyl-shinorine (13.2%) and porphyra-334 (0.2%). β-Gal-P334 had an absorption maximum at 334nm and molecular absorption coefficient was 46,700 at 334nm...
May 15, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28544922/efficacy-of-benzalkonium-chloride-against-bioluminescent-p-aeruginosa-atcc9027-constructs
#9
N Shah, D C Naseby
Whole cell biosensors have been seldom used in the pharmaceutical and cosmetics industries for preservative efficacy testing (PET). According to several pharmacopoeias, preservatives should be tested for microbial activity using traditional viable count techniques; the use of whole cell microbial biosensors potentially provides an alternative, fast, and efficient method. The aim of the study was to assess the applicability of Pseudomonas aeruginosa ATCC9027 and its validated bioluminescent strains for preservative efficacy tests using benzalkonium chloride (BKC)...
April 23, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28544902/extraction-and-applications-of-cyanotoxins-and-other-cyanobacterial-secondary-metabolites
#10
REVIEW
Fatima Haque, Sara Banayan, Josephine Yee, Yi Wai Chiang
The rapid proliferation of cyanobacteria in bodies of water has caused cyanobacterial blooms, which have become an increasing cause of concern, largely due to the presence of toxic secondary metabolites (or cyanotoxins). Cyanotoxins are the toxins produced by cyanobacteria that may be harmful to surrounding wildlife. They include hepatotoxins, neurotoxins and dermatotoxins, and are classified based on the organs they affect. There are also non-toxic secondary metabolites that include chelators and UV-absorbing compounds...
May 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28544730/human-skin-gene-expression-doesn-t-correlate-with-protein-expression-unless-both-parameters-are-quantified
#11
Edwin D Lephart
Many cosmetic companies utilize in vitro gene array studies to display significant stimulation or inhibition of various human skin biomarkers to validate in vivo actions that are reported to enhance dermal health. This follows the central dogma of DNA-to-RNA results in protein expression; however, gene and protein expressions do not usually correlate. Unless both gene and protein expressions are quantified which require further investigational time and investment. Where data are available, this short commentary displays the in vitro comparison of four human skin biomarkers for the gene and protein expressions of the stimulation of collagen type I and elastin and the inhibition of matrix metalloproteinases 1 and 3, when equol was tested...
May 25, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28543587/optical-mapping-of-nonmelanoma-skin-cancers-a-pilot-clinical-study
#12
Anna N Yaroslavsky, Xin Feng, Victor A Neel
BACKGROUND AND OBJECTIVE: Nonmelanoma skin cancer (NMSC) is the most common human cancer. Because these tumors often affect the face, there is a strong need for both accurate removal of these neoplasms to prevent recurrence and maximal tissue preservation to prevent cosmetic or functional deformity. Polarization-enhanced reflectance and fluorescence imaging (PERFI) is a new bedside method that uses fluorescent chromophores to image NMSC. While the feasibility of the technique has been successfully demonstrated in ex vivo studies, this is the first pilot study to extend the use of PERFI to in vivo intraoperative imaging of NMSC...
May 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28543036/self-assembly-of-two-hydrophobins-from-marine-fungi-affected-by-interaction-with-surfaces
#13
Paola Cicatiello, Principia Dardano, Marinella Pirozzi, Alfredo Maria Gravagnuolo, Luca De Stefano, Paola Giardina
Hydrophobins are amphiphilic fungal proteins endowed with peculiar characteristics, such as a high surface activity and an interface triggered self-assembly. Several applications of these proteins have been proposed in the food, cosmetics and biomedical fields. Moreover, their use as proteinaceous coatings can be effective for materials and nanomaterials applications. The discovery of novel hydrophobins with diverse properties may be advantageous from both the scientific and industrial points of view. Stressful environmental conditions of fungal growth may induce the production of proteins with peculiar features...
May 22, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28542816/identification-of-microorganisms-isolated-from-counterfeit-and-unapproved-decorative-contact-lenses
#14
Adrian D Land, Katie L Penno, Jennifer L Brzezinski
All contact lenses (corrective/noncorrective) are considered Class II or Class III medical devices under the Federal Food, Drug, and Cosmetic Act, which also states that contact lenses can only be obtained with a prescription. The Forensic Chemistry Center of the US Food & Drug Administration has examined over 300 decorative, noncorrective contact lenses obtained without a prescription. Our observations indicate that 60% of the counterfeit lenses and 27% of the unapproved lenses examined were positive for microbial contamination...
May 24, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28542395/carvacrol-derivatives-as-mushroom-tyrosinase-inhibitors-synthesis-kinetics-mechanism-and-molecular-docking-studies
#15
Zaman Ashraf, Muhammad Rafiq, Humaira Nadeem, Mubashir Hassan, Samina Afzal, Muhammad Waseem, Khurram Afzal, Jalifah Latip
The present work describesthe development of highly potent mushroom tyrosinase inhibitor better than the standard kojic acid. Carvacrol derivatives 4a-f and 6a-d having substituted benzoic acid and cinnamic acidresidues were synthesized with the aim to possess potent tyrosinase inhibitory activity.The structures of the synthesized compounds were ascertained by their spectroscopic data (FTIR, 1HNMR, 13CNMR and Mass Spectroscopy).Mushroom tyrosinase inhibitory activity of synthesized compounds was determined and it was found that one of the derivative 6c possess higher activity (IC50 0...
2017: PloS One
https://www.readbyqxmd.com/read/28540795/radiofrequency-ablation-of-benign-thyroid-nodules-depicting-early-sign-of-regrowth-by-calculating-vital-volume
#16
Jung Suk Sim, Jung Hwan Baek, Joongyub Lee, Woojin Cho, Sung Il Jung
OBJECTIVE: We evaluated long-term follow-up results of radiofrequency ablation of benign thyroid nodules to analyse the role of marginal vital tissue on nodule regrowth. MATERIALS AND METHODS: We reviewed the medical records of 54 patients who underwent radiofrequency ablation between June 2008 and November 2013 with pressure symptoms, and/or cosmetic problems. All patients were followed up at least 12 months on three occasions. To evaluate an early sign of regrowth, three types of nodule volumes (total volume, ablated volume and vital volume) were measured and calculated using ultrasonography...
April 10, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540552/application-of-ruo2-ni-foam-electrodes-for-remediation-of-ibuprofen-in-soil-matrix-the-effect-of-electrokinetic-parameters
#17
Ching Yuan, Chung-Hsuang Hung, Tzu-Yuan Huang
Pharmaceuticals and personal care products (PPCPs) are an extraordinary and diverse group of chemicals used in veterinary medicine, agriculture, and for human health and cosmetics care. They are considered emerging contaminants and have raised great concern in recent years. Among the PPCPs, ibuprofen (IBP) is one of the most known non-steroidal anti-inflammatory drugs, which has been found at a high concentration in irrigation water in the USA and showed harmful effect for organisms. This study examined IBP degradation performance by an electrokinetic process coupled with 24-96 cm(2) of RuO2/Ni foam (RN) electrodes applied 1-3 V cm(-1) potential gradient for 5-9 days...
May 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28540461/quantitative-analysis-of-curcumin-loaded-alginate-nanocarriers-in-hydrogels-using-raman-and-attenuated-total-reflection-infrared-spectroscopy
#18
Lynda Miloudi, Franck Bonnier, Dominique Bertrand, Hugh J Byrne, Xavier Perse, Igor Chourpa, Emilie Munnier
Core-shell nanocarriers are increasingly being adapted in cosmetic and dermatological fields, aiming to provide an increased penetration of the active pharmaceutical or cosmetic ingredients (API and ACI) through the skin. In the final form, the nanocarriers (NC) are usually prepared in hydrogels, conferring desired viscous properties for topical application. Combined with the high chemical complexity of the encapsulating system itself, involving numerous ingredients to form a stable core and quantifying the NC and/or the encapsulated active without labor-intensive and destructive methods remains challenging...
May 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28540437/volatile-organic-compounds-and-good-laboratory-practices-in-the-in-vitro-fertilization-laboratory-the-important-parameters-for-successful-outcome-in-extended-culture
#19
Nupur Agarwal, Ratna Chattopadhyay, Sanghamitra Ghosh, Arpita Bhoumik, S K Goswami, Baidyanath Chakravarty
PURPOSE: This study aims to describe the role of implementing good laboratory practices to improve in vitro fertilization (IVF) outcomes which are of great interest for practitioners dealing with infertility. METHODS: Certain modifications were introduced in May 2015 in our IVF laboratory like high-efficiency particulate air CODA system, steel furniture instead of wooden, use of new disinfectants like oosafe, and restriction of personnel entry along with avoidance of cosmetics like perfume to improve pregnancy rates...
May 24, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28540347/interdisciplinary-management-of-head-and-neck-vascular-anomalies-clinical-presentation-diagnostic-findings-and-minimalinvasive-therapies
#20
REVIEW
Maliha Sadick, Walter A Wohlgemuth, Roland Huelse, Bettina Lange, Thomas Henzler, Stefan O Schoenberg, Haneen Sadick
OBJECTIVES: Vascular anomalies are included in the 30 000 rare diseases worldwide affecting less than 5/10 000 people. Depending on their morphology and biological properties, they can cause varied disorders with organ involvement. Almost 60% of vascular anomalies have a predilection for the head and neck region in children. Clinical and scientific effort to establish interdisciplinary management concepts for vascular anomalies is increasing worldwide. METHODS: Especially in the head and neck region, clinical impairment and organ dysfunction is associated with cosmetic issues that may represent a physical and psychological issue for the patient...
2017: European Journal of Radiology Open
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