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https://www.readbyqxmd.com/read/28214239/feasibility-and-factor-structure-of-the-frail-scale-in-older-adults
#1
Ivan Aprahamian, Sumika Mori Lin, Claudia Kimie Suemoto, Daniel Apolinario, Natália Oiring de Castro Cezar, Serpui Marie Elmadjian, Wilson Jacob Filho, Mônica Sanches Yassuda
OBJECTIVES: The aim of the present study was to (1) evaluate a geriatric outpatient sample with the FRAIL scale; (2) investigate the psychometric properties of the scale; and (3) characterize different associations of the subdimensions of the scale with demographic and clinical data. DESIGN: Cross-sectional observational study. SETTING: Geriatric outpatient center a university-based hospital in São Paulo, Brazil. PARTICIPANTS: A total of 811 men and women aged 60 years or older evaluated between March 2015 and September 2015...
February 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28207917/the-role-of-ect-in-posttraumatic-stress-disorder-a-systematic-review
#2
Nagy A Youssef, W Vaughn McCall, Chittaranjan Andrade
BACKGROUND: Posttraumatic stress disorder (PTSD) is associated with a high burden of disability and mortality and frequently is treatment resistant. There is little to offer patients who are not responding to standard interventions. Thus, the objective of this report is to systematically review human data on whether electroconvulsive therapy (ECT) is effective in PTSD. METHODS: We performed a systematic literature review from 1958 through August 2016 for clinical studies and case reports published in English examining the efficacy of ECT in improving PTSD symptoms...
February 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28207329/longitudinal-patterns-and-predictors-of-depression-trajectories-related-to-the-2014-occupy-central-umbrella-movement-in-hong-kong
#3
Michael Yuxuan Ni, Tom Kung Leung Li, Herbert Hei Man Pang, Brandford Ho Yeung Chan, Ichiro Kawachi, Kasisomayajula Viswanath, Catherine Mary Schooling, Gabriel Matthew Leung
OBJECTIVES: To examine the longitudinal patterns and predictors of depression trajectories before, during, and after Hong Kong's 2014 Occupy Central/Umbrella Movement. METHODS: In a prospective study, between March 2009 and November 2015, we interviewed 1170 adults randomly sampled from the population-representative FAMILY Cohort. We used the Patient Health Questionnaire-9 to assess depressive symptoms and probable major depression. We investigated pre-event and time-varying predictors of depressive symptoms...
February 16, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28198046/muscle-fatigability-and-depressive-symptoms-in-later-life
#4
Patrick J Brown, Dala Badreddine, Steven P Roose, Bret Rutherford, Hilsa N Ayonayon, Kristine Yaffe, Eleanor M Simonsick, Bret Goodpaster
OBJECTIVE: Fatigability is the degree to which performance decreases during a specific activity of a given intensity and duration. Depression is known to heighten subjective fatigue, but whether its association with physical fatigability is unknown. Further, whether fatigability is a precursor or risk factor for the development of subsequent depressive symptoms is also unclear. METHODS: Data are from the Health Aging and Body Composition Study with fatigability assessed using isokinetic dynamometry of the knee extensors at year 3, and depressive symptoms ascertained longitudinally using the Center for Epidemiologic Studies Depression (CES-D) scale...
February 15, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28187008/guarding-the-gate-remote-structured-assessments-to-enhance-enrollment-precision-in-depression-trials
#5
Marlene P Freeman, James Pooley, Martina J Flynn, Lee Baer, David Mischoulon, David Mou, Maurizio Fava
BACKGROUND: Failed treatment trials are common in major depressive disorder and treatment-resistant depression, and remotely performed multifaceted, centralized structured interviews can potentially enhance signal detection by ensuring that enrolled patients meet eligibility criteria. METHODS: We assessed the use of a specific remote structured interview that validated the diagnosis, level of treatment resistance, and depression severity. The objectives were to (1) assess the rate at which patients who were deemed eligible for participation in trials by site investigators were ineligible, (2) assess the reasons for ineligibility, (3) compare rates of ineligibility between academic and nonacademic sites, (4) compare eligibility between US and non-US sites, and (5) report the placebo response rates in trials utilizing this quality assurance approach, comparing its placebo response rates with those reported in the literature...
February 10, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28184334/mixed-states-in-bipolar-disorder-etiology-pathogenesis-and-treatment
#6
REVIEW
Ather Muneer
Many bipolar disorder patients exhibit mixed affective states, which portend a generally more severe illness course and treatment resistance. In the previous renditions of Diagnostic and Statistical Manual mixed states were narrowly defined in the context of bipolar I disorder, but with the advent of DSM-5 the term "mixed episode" was dropped and replaced by "mixed features" specifier which could be broadly applied to manic, hypomanic and depressive episodes in both the bipolar spectrum and major depressive disorders...
January 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28184199/oxidative-modification-in-the-salivary-glands-of-high-fat-diet-induced-insulin-resistant-rats
#7
Urszula Kołodziej, Mateusz Maciejczyk, Agnieszka Miąsko, Jan Matczuk, Małgorzata Knaś, Piotr Żukowski, Małgorzata Żendzian-Piotrowska, Jan Borys, Anna Zalewska
Still little is known about the role of oxidative stress (OS) in the pathogenesis of the salivary gland dysfunction in the course of insulin resistance (IR). To induce IR rats was fed with a high fat diet (HFD) during 8 weeks. Stimulated and non-stimulated salivary flow rate, total protein, as well as oxidative damage markers: 4-HNE protein adduct, 8-isoprostanes (8-isoP), 8-hydroxy-D-guanosine (8-OHdG), advanced oxidation protein product (AOPP), and protein carbonyls (PC) were determined in the plasma and submandibular and parotid glands of IR and control rats...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28179267/obesity-and-pregnancy-mechanisms-of-short-term-and-long-term-adverse-consequences-for-mother-and-child
#8
REVIEW
Patrick M Catalano, Kartik Shankar
Obesity is the most common medical condition in women of reproductive age. Obesity during pregnancy has short term and long term adverse consequences for both mother and child. Obesity causes problems with infertility, and in early gestation it causes spontaneous pregnancy loss and congenital anomalies. Metabolically, obese women have increased insulin resistance in early pregnancy, which becomes manifest clinically in late gestation as glucose intolerance and fetal overgrowth. At term, the risk of cesarean delivery and wound complications is increased...
February 8, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28179035/impact-of-deep-brain-stimulation-of-the-ventral-anterior-limb-of-the-internal-capsule-on-cognition-in-depression
#9
I O Bergfeld, M Mantione, M L C Hoogendoorn, H G Ruhé, F Horst, P Notten, J van Laarhoven, P van den Munckhof, G Beute, P R Schuurman, D Denys
BACKGROUND: Preliminary studies report no negative and a possible positive impact of deep brain stimulation (DBS) on cognition of patients with treatment-resistant depression (TRD). However, these studies neither controlled for practice effects nor compared active with sham stimulation. METHOD: To address these limitations, we compared 25 TRD patients, who underwent DBS of the ventral anterior limb of the internal capsule (vALIC), with 21 healthy controls (HCs) matched on gender, age and education level...
February 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28177952/clinical-factors-related-to-acute-electroconvulsive-therapy-outcome-for-patients-with-major-depressive-disorder
#10
Cheng-Chung Chen, Ching-Hua Lin, Wei-Cheng Yang, Ming-Chao Chen
The aim of this study was to explore the significant predictors associated with electroconvulsive therapy (ECT) outcome for patients with major depressive disorder. Major depressive disorder inpatients (N=130) requiring ECT were recruited from a major psychiatric center in South Taiwan. ECT was generally performed for a maximum of 12 sessions. Symptom severity was assessed using the 17-item Hamilton Depression Rating Scale (HAMD-17) and Clinical Global Impression of Severity (CGI-S) before ECT, after every three ECT sessions, and after the last ECT...
February 7, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28174436/cardiovascular-response-to-bouts-of-exercise-with-blood-flow-restriction
#11
Kestutis Bunevicius, Arturas Sujeta, Kristina Poderiene, Birute Zachariene, Viktoras Silinskas, Rimantas Minkevicius, Jonas Poderys
[Purpose] Occlusion training with low-intensity resistance exercises and blood flow restriction increases muscle cross-sectional area and strength. This form of training is used in rehabilitation; therefore, the aim of this study was to examine the effect of one occlusion training session on the cardiovascular response to bouts of exercise. [Subjects and Methods] Two groups took part: a control group without blood flow restriction and an experimental group with blood flow restriction. A single training session was used with the exercise intensity set at 40% of the one repetition maximum...
December 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28170003/brain-volumetric-and-metabolic-correlates-of-electroconvulsive-therapy-for-treatment-resistant-depression-a-longitudinal-neuroimaging-study
#12
M Cano, I Martínez-Zalacaín, Á Bernabéu-Sanz, O Contreras-Rodríguez, R Hernández-Ribas, E Via, A de Arriba-Arnau, V Gálvez, M Urretavizcaya, J Pujol, J M Menchón, N Cardoner, C Soriano-Mas
Recent research suggests that neuroplastic and neuroinflammatory changes may account for the mode of action of electroconvulsive therapy (ECT), although extant data do not allow for a clear disambiguation between these two hypotheses. Multimodal neuroimaging approaches (for example, combining structural and metabolic information) may help in clarifying this issue. Here we aimed to assess longitudinal changes in (i) regional gray matter (GM) volumes and (ii) hippocampal metabolite concentrations throughout an acute course of bitemporal ECT, as well as (iii) to determine the association between imaging changes and clinical improvement...
February 7, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28169947/cognitive-performance-under-electroconvulsive-therapy-ect-in-ect-naive-treatment-resistant-patients-with-major-depressive-disorder
#13
Christoph Ziegelmayer, Göran Hajak, Anne Bauer, Marion Held, Rainer Rupprecht, Wolfgang Trapp
OBJECTIVES: Although electroconvulsive therapy (ECT) is considered a safe and highly effective treatment option for major depressive disorder, there are still some reservations with regard to possible adverse cognitive adverse effects. This is the case despite a large body of evidence showing that these deficits are transient and that there even seems to be a long-term improvement of cognitive functioning level. However, most data concerning cognitive adverse effects stem from studies using mixed samples of treatment-resistant and non-treatment-resistant as well as ECT-naive and non-ECT-naive subjects...
February 7, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28168992/the-relationship-between-atypical-depression-and-ins%C3%A3-lin-resistance-in-patients-with-polycystic-ovary-syndrome-and-major-depression
#14
Osman Özdemir, Zehra Kurdoglu, Saliha Yıldız, Pınar Güzel Özdemir, Ekrem Yilmaz
In this study, we aimed to examine the relationship between atypical depression and insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS) and major depression. A total of 176 subjects (69 patients with PCOS, 58 patients with depression, and 49 healthy controls) were included in the study. The Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Beck Hopelessness Scale (BHS), and the Scale for Suicide Ideation (SSI) were administered. Data concerning their height, weight, fasting a...
December 3, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28162976/neuromodulation-in-response-to-electroconvulsive-therapy-in-schizophrenia-and-major-depression
#15
Philipp Arthur Thomann, Robert Christian Wolf, Henrike Maria Nolte, Dusan Hirjak, Stefan Hofer, Ulrich Seidl, Malte Sebastian Depping, Bram Stieltjes, Klaus Maier-Hein, Fabio Sambataro, Torsten Wüstenberg
BACKGROUND: Electroconvulsive therapy (ECT) is one of the most effective treatments in severe and treatment-resistant major depressive disorder (MDD). ECT has been also shown to be effective in schizophrenia (SZ), particularly when rapid symptom reduction is needed or in cases of resistance to drug-treatment. However, its precise mechanisms of action remain largely unknown. OBJECTIVE/HYPOTHESIS: This study examined whether ECT exerts disorder-specific or unspecific modulation of brain structure and function in SZ and MDD...
January 16, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28157566/-i-don-t-know-how-i-m-still-standing-a-bakhtinian-analysis-of-social-housing-and-health-narratives-in-east-london
#16
C Thompson, D J Lewis, T Greenhalgh, N R Smith, A E Fahy, S Cummins
Housing is a significant determinant of health and substandard housing is a public health issue. East London has long had a shortage of social and affordable housing, worsened in recent years by a combination of stressors. In one of East London's most deprived boroughs, Newham, changes brought about by the 2011 Localism Act and the unique demands of being the host Olympic borough in 2012 have brought considerable pressures to bear on social infrastructure. This paper examines how these pressures were experienced by local residents via their narratives of social housing and health...
January 25, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28156615/investigating-high-concentration-8-capsaicin-patch-in-chronic-cancer-treatment-related-peripheral-neuropathic-pain
#17
Barry Laird, Linda J Williams, Marie T Fallon
: 208 Background: Cancer-treatment related peripheral neuropathic pain is a challenging clinical problem as current interventions have limited efficacy and significant toxicities. This study aims to examine the analgesic effect of high-concentration 8% capsaicin patch in this cohort of patients. METHODS: A single arm study was conducted. Patients with long-term peripheral neuropathic pain received a single application of 8% transdermal capsaicin patch to the affected area (chest wall, hands or feet)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28155119/a-combination-of-probiotics-and-magnesium-orotate-attenuate-depression-in-a-small-ssri-resistant-cohort-an-intestinal-anti-inflammatory-response-is-suggested
#18
Matthew Bambling, Sophie C Edwards, Sean Hall, Luis Vitetta
Approximately, one-third of those who develop major depression will have a poor response to treatment and over time can become treatment resistant. Intestinal dysbiosis has been implicated in depression with systemic inflammation and vagal and enteric nerve impairment. We report on a sequel pilot study (n = 12) with a combination probiotics/magnesium orotate formulation adjuvant administered with SSRIs for treatment resistant depression. At the end of an 8-week intervention mean changes for depression scores and quality of life in the group was clinically significantly improved (p < 0...
February 2, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28154905/changes-in-dorsolateral-prefrontal-connectivity-after-rtms-in-treatment-resistant-depression-a-brain-perfusion-spect-study
#19
Raphaëlle Richieri, Damien Jouvenoz, Antoine Verger, Patrick Fiat, Laurent Boyer, Christophe Lançon, Eric Guedj
PURPOSE: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and safe alternative to electroconvulsive therapy for treatment-resistant depression (TRD). After rTMS, changes in brain SPECT perfusion have been remotely identified within medial temporal limbic areas, while no local effects have been found within the left dorsolateral prefrontal cortex (DLPFC)-i.e. under the coil. Functional changes in connectivity may underlie these remote effects. Interestingly, functional connectivity has been recently investigated using perfusion SPECT, and abnormalities identified in TRD patients...
February 3, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28152396/insulin-resistance-atherogenicity-and-iron-metabolism-in-multiple-sclerosis-with-and-without-depression-associations-with-inflammatory-and-oxidative-stress-biomarkers-and-uric-acid
#20
Sayonara Rangel Oliveira, Ana Paula Kallaur, Josiane Lopes, Andrea Name Colado Simão, Edna Maria Vissoci Reiche, Elaine Regina Delicato de Almeida, Helena Kaminami Morimoto, Wildea Lice de Carvalho Jennings de Pereira, Daniela Frizon Alfieri, Tamires Flauzino, Caio de Meleck Proença, Anna Maria Gomes, Damacio Ramón Kaimen-Maciel, Michael Maes
Depression is accompanied by metabolic disorders in iron metabolism, lipoproteins, and insulin resistance. We measured plasma levels of ferritin, iron, lipids, insulin, and glucose and computed the homeostasis model assessment (HOMA2IR) and atherogenic index of plasma (AIP) in MS patients with and without depression and healthy controls. Explanatory variables were serum uric acid, interleukin (IL)-6, lipid hydroperoxides (CL-LOOH), albumin, and C-reactive protein (CRP). Depression was assessed using the Hospital Anxiety and Depression Scale (HADS), neurological disability using the Expanded Disability Status Scale (EDSS), and disease progression using ∆EDSS over five years earlier...
December 27, 2016: Psychiatry Research
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