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https://www.readbyqxmd.com/read/28225022/core-shell-nanoparticle-arrays-double-the-strength-of-steel
#1
J-B Seol, S-H Na, B Gault, J-E Kim, J-C Han, C-G Park, D Raabe
Manipulating structure, defects and composition of a material at the atomic scale for enhancing its physical or mechanical properties is referred to as nanostructuring. Here, by combining advanced microscopy techniques, we unveil how formation of highly regular nano-arrays of nanoparticles doubles the strength of an Fe-based alloy, doped with Ti, Mo, and V, from 500 MPa to 1 GPa, upon prolonged heat treatment. The nanoparticles form at moving heterophase interfaces during cooling from the high-temperature face-centered cubic austenite to the body-centered cubic ferrite phase...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28218524/general-fabrication-of-boride-carbide-and-nitride-nanocrystals-via-a-metal-hydrolysis-assisted-process
#2
Ling Zhou, Lishan Yang, Li Shao, Bo Chen, Fanhui Meng, Yitai Qian, Liqiang Xu
Metal boride, carbide, and nitride materials are useful owing to their wide variety of interesting chemical and physical properties. However, the synthesis of these materials with nano or mesoscale sizes is challenging due to the usually required high temperatures and long reaction durations. To our knowledge, the exploration of a number of simultaneous chemical reactions through rapid synthesis still remains a great challenge. In this study, a general route for the reduction and transformation of metal oxides into related metal boride (TiB2, MoB2, DyB4, ErB4, YB4, LaB6, CeB6, SmB6, EuB6), carbide (SiC, TiC, VC, WC, W2C, ZrC, MoC, NbC), and nitride (TiN, VN, BN, AlN, CrN, MgSiN2) nanocrystals were achieved at 150 °C...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28216123/ablation-of-the-auditory-cortex-results-in-changes-in-the-expression-of-neurotransmission-related-mrnas-in-the-cochlea
#3
Verónica Lamas, José M Juiz, Miguel A Merchán
The auditory cortex (AC) dynamically regulates responses of the Organ of Corti to sound through descending connections to both the medial (MOC) and lateral (LOC) olivocochlear efferent systems. We have recently provided evidence that AC has a reinforcement role in the responses to sound of the auditory brainstem nuclei. In a molecular level, we have shown that descending inputs from AC are needed to regulate the expression of molecules involved in outer hair cell (OHC) electromotility control, such as prestin and the α10 nicotinic acetylcholine receptor (nAchR)...
February 16, 2017: Hearing Research
https://www.readbyqxmd.com/read/28211069/mglur1-enhances-efferent-inhibition-of-inner-hair-cells-in-the-developing-rat-cochlea
#4
Zhanlei Ye, Juan D Goutman, Sonja J Pyott, Elisabeth Glowatzki
Just before the onset of hearing, the inner hair cells (IHCs) receive inhibitory efferent input from cholinergic medial olivocochlear (MOC) neurons originating in the brainstem. This input may serve a role in the maturation of the ascending (afferent) auditory system by inhibiting spontaneous activity of the IHCs. To investigate the molecular mechanisms regulating these IHC efferent synapses, we combined electrical stimulation of the efferent fibres with patch clamp recordings from the IHCs to measure efferent synaptic strength...
February 17, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28209346/reliability-of-tms-phosphene-threshold-estimation-toward-a-standardized-protocol
#5
Chiara Mazzi, Silvia Savazzi, Arman Abrahamyan, Manuela Ruzzoli
BACKGROUND: Phosphenes induced by transcranial magnetic stimulation (TMS) are a subjectively described visual phenomenon employed in basic and clinical research as index of the excitability of retinotopically organized areas in the brain. OBJECTIVE: Phosphene threshold estimation is a preliminary step in many TMS experiments in visual cognition for setting the appropriate level of TMS doses; however, the lack of a direct comparison of the available methods for phosphene threshold estimation leaves unsolved the reliability of those methods in setting TMS doses...
February 2, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28188882/intelligibility-in-speech-maskers-with-a-binaural-cochlear-implant-sound-coding-strategy-inspired-by-the-contralateral-medial-olivocochlear-reflex
#6
Enrique A Lopez-Poveda, Almudena Eustaquio-Martín, Joshua S Stohl, Robert D Wolford, Reinhold Schatzer, José M Gorospe, Santiago Santa Cruz Ruiz, Fernando Benito, Blake S Wilson
We have recently proposed a binaural cochlear implant (CI) sound processing strategy inspired by the contralateral medial olivocochlear reflex (the MOC strategy) and shown that it improves intelligibility in steady-state noise (Lopez-Poveda et al., 2016, Ear Hear 37:e138-e148). The aim here was to evaluate possible speech-reception benefits of the MOC strategy for speech maskers, a more natural type of interferer. Speech reception thresholds (SRTs) were measured in six bilateral and two single-sided deaf CI users with the MOC strategy and with a standard (STD) strategy...
February 7, 2017: Hearing Research
https://www.readbyqxmd.com/read/28145032/national-treatment-programme-of-hepatitis-c-in-egypt-hepatitis-c-virus-model-of-care
#7
REVIEW
W El-Akel, M H El-Sayed, M El Kassas, M El-Serafy, M Khairy, K Elsaeed, K Kabil, M Hassany, A Shawky, A Yosry, M K Shaker, Y ElShazly, I Waked, G Esmat, W Doss
Hepatitis C virus (HCV) infection is a major health problem in Egypt as the nation bears the highest prevalence rate worldwide. This necessitated establishing a novel model of care (MOC) to contain the epidemic, deliver patient care and ensure global treatment access. In this review, we describe the process of development of the Egyptian model and future strategies for sustainability. Although the magnitude of the HCV problem was known for many years, the HCV MOC only came into being in 2006 with the establishment of the National Committee for Control of Viral Hepatitis (NCCVH) to set up and implement a national control strategy for the disease and other causes of viral hepatitis...
February 1, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28125363/evaluation-of-the-asco-value-framework-for-anticancer-drugs-at-an-academic-medical-center
#8
Leslie Wilson, Tracy Lin, Ling Wang, Tanuja Patel, Denise Tran, Sarah Kim, Katie Dacey, Courtney Yuen, Lisa Kroon, Bret Brodowy, Kevin Rodondi
BACKGROUND: Anticancer drug prices have increased by an average of 12% each year from 1996 to 2014. A major concern is that the increasing cost and responsibility of evaluating treatment options are being shifted to patients. This research compared 2 value-based pricing models that were being considered for use at the University of California, San Francisco (UCSF) Medical Center to address the growing burden of high-cost cancer drugs while improving patient-centered care. PROGRAM DESCRIPTION: The Medication Outcomes Center (MOC) in the Department of Clinical Pharmacy, University of California, San Francisco (UCSF), School of Pharmacy focuses on assessing the value of medication-related health care interventions and disseminating findings to the UCSF Medical Center...
February 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28118038/quality-metrics-currently-used-in-academic-radiology-departments-results-of-the-qualmet-survey
#9
Eric A Walker, Jonelle M Petscavage-Thomas, Joseph S Fotos, Michael A Bruno
OBJECTIVES: We present the results of the 2015 QUALMET survey, which was designed to assess the commonalities and variability of selected quality and productivity metrics currently employed by a large sample of academic radiology departments representing all regions in the United States. METHODS: The survey of key radiology metrics was distributed in March-April of 2015 via personal e-mail to 112 academic radiology departments. RESULTS: There was a 34...
January 24, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28102467/mypod-an-emr-based-tool-that-facilitates-quality-improvement-and-maintenance-of-certification
#10
Loren Berman, Brian Duffy, B Randall Brenn, Charles Vinocur
Maintenance of Certification (MOC) was designed to assess physician competencies including operative case volume and outcomes. This information, if collected consistently and systematically, can be used to facilitate quality improvement. Information automatically extracted from the electronic medical record (EMR) can be used as a prompt to compile these data. We developed an EMR-based program called MyPOD (My Personal Outcomes Data) to track surgical outcomes at our institution. We compared occurrences reported in the first 18 months to those captured in the American College of Surgeons National Surgical Quality Improvement Program-Pediatric (ACS NSQIP-P) over the same time period...
March 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28094531/cyanoform-and-its-isomers-relative-stabilities-spectroscopic-features-and-rearrangements-by-coupled-cluster-and-mcscf-based-methods
#11
Marek Szczepaniak, Jerzy Moc
Although an isolation of elusive tricyanomethane HC(CN)3 was recently reported, the existence of other HC4N3 species has yet to be confirmed. In this work, the relative stabilities, spectroscopic features, and rearrangements of tricyanomethane and its four isomers are examined using single- (CCSD(T), CCSD(T)-F12) and multireference (MCSCF, MRPT2) methods. Tricyanomethane and dicyanoketenimine (NC)2CCNH, which are found to be the two most stable HC4N3 isomers lying within 9 kcal/mol, can be discriminated by their spectroscopic parameters...
February 6, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28094459/investigation-of-binding-behavior-between-drug-molecule-5-fluoracil-and-m4-l4-type-tetrahedral-cages-selectivity-capture-and-release
#12
Wei-Qin Xu, Yan-Zhong Fan, Hai-Ping Wang, Jun Teng, Yu-Hao Li, Cheng-Xia Chen, Dieter Fenske, Ji-Jun Jiang, Cheng-Yong Su
Two analogous M4 L4 -type tetrahedral cages (smaller: MOC-19; larger: MOC-22) were synthesized and investigated for their interactions with the anticancer drug 5-fluoracil (5-FU) by NMR spectroscopy, high-resolution electrospray-ionization mass spectrometry (HR-ESI-MS), and molecular simulation. The cage's size and window are of importance for the host-guest binding, and consequently the smaller MOC-19 with a more suitable size of cavity window was found to have much stronger hydrogen-bond interactions with 5-FU...
January 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28065344/abai-s-moc-assessment-of-knowledge-program-matures-adding-value-with-continuous-learning-and-assessment
#13
REVIEW
David I Bernstein, Stephen I Wasserman, William P Thompson, Theodore M Freeman
Rapid changes in modern medicine along with advances in the science of learning and memory have necessitated a shift in the way physician knowledge is assessed. Physician recertification beyond initial certification has historically consisted of retaining large amounts of knowledge over a long time span. The adult learning theory has shown that the maintenance and improvement of our knowledge base is more effective by being exposed to new concepts at regular intervals throughout one's career and reinforcing these concepts on an ongoing basis...
January 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28057551/metabolite-inactive-etomidate-analogues-alleviating-suppression-on-adrenal-function-in-beagle-dogs
#14
Jun Yang, Yi Kang, Bin Wang, Linghui Yang, Jin Liu, Wensheng Zhang
Owing to rapid generation in body, the metabolites of etomidate softdrug are able to accumulate in either the brain or periphery and subsequently affect the recovery from anaesthesia or cause corticosteroid suppression. This study was designed to investigate the ability of two etomidate analogues (ET-26, ET-42) with inactive metabolites to provide anaesthesia with lesser corticosteroid suppression. The 50% effective dose (ED50) of ET-26, ET-42, Etomidate, MOC-ET (an etomidate softdrug) and CPMM (an improved etomidate softdrug) required to induce anaesthesia intravenously in Beagle dogs were 1...
March 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28049728/familial-alzheimer-s-disease-mutations-within-the-amyloid-precursor-protein-alter-the-aggregation-and-conformation-of-the-amyloid-beta-peptide
#15
Asa Hatami, Sanaz Monjazeb, Saskia Milton, Charles G Glabe
Most cases of Alzheimer's disease (AD) are sporadic, while a small percentage of AD cases, called familial AD (FAD), are associated with mutations in presinilins 1 and 2 and the amyloid precursor protein (APP). APP mutations falling within the Aβ sequence lead to a wide range of disease phenotypes. There is increasing evidence that distinct amyloid structures distinguished by amyloid conformation-dependent monoclonal antibodies have varying roles in pathology. It is possible that the phenotypic diversity of FAD associated with mutations within the Aβ sequence is due to differences in the conformations adopted by mutant Aβ peptides...
January 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28048741/mo-g-204-00-the-american-board-of-radiology-maintenance-of-certification-process
#16
G Donald Frey
1. The participants will understand how to comply with the revised ABR MOC requirements 2. The participants be able to utilize the new Participatory PQI into their MOC program 3. The participants will be able to comply with the ABR MOC simplified attestation requirements 4. The participants will be able to meet the requirements for the annual ABR MOC lookback This presentation will update medical physicists about the American Board of Radiology Maintenance of Certification (MOC) process. The MOC process has recently undergone a number of significant changes and this presentation will review these for the attendees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048358/th-f-201-01-the-problem-is-this-a-trick-question
#17
C Bloch
: Multiple choice questions are a tool medical physicists encounter throughout their careers. They are a commonly used method of assessment during our early didactic training (graduate school, residency and board certification). They are used throughout our MOC process both in SAMs and online CE. And they are used for the MOC exam every 10 years. While we have significant training in answering these multiple choice questions, we rarely receive training in how to construct effective multiple choice questions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048084/mo-g-204-01-current-moc-requirements-with-an-emphasis-on-recent-changes
#18
M Herman
1. The participants will understand how to comply with the revised ABR MOC requirements 2. The participants be able to utilize the new Participatory PQI into their MOC program 3. The participants will be able to comply with the ABR MOC simplified attestation requirements 4. The participants will be able to meet the requirements for the annual ABR MOC lookback This presentation will update medical physicists about the American Board of Radiology Maintenance of Certification (MOC) process. The MOC process has recently undergone a number of significant changes and this presentation will review these for the attendees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047713/th-f-201-02-the-solution-the-science-behind-writing-good-questions
#19
S Richardson
: Multiple choice questions are a tool medical physicists encounter throughout their careers. They are a commonly used method of assessment during our early didactic training (graduate school, residency and board certification). They are used throughout our MOC process both in SAMs and online CE. And they are used for the MOC exam every 10 years. While we have significant training in answering these multiple choice questions, we rarely receive training in how to construct effective multiple choice questions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047681/su-f-e-07-web-based-training-for-radiosurgery-methods-and-metrics-for-global-reach
#20
R Schulz, E Thomas, R Popple, J Fiveash, E Jacobsen
PURPOSE: Webinars have become an evolving tool with greater or lesser success in reaching health care providers (HCPs). This study seeks to assess best practices and metrics for success in webinar deployment for optimal global reach. METHODS: Webinars have been developed and launched to reach practicing health care providers in the field of radiation oncology and radiosurgery. One such webinar was launched in early February 2016. "Multiple Brain Metastases & Volumetric Modulated Arc Radiosurgery: Refining the Single-Isocenter Technique to Benefit Surgeons and Patients" presented by Drs...
June 2016: Medical Physics
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