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https://www.readbyqxmd.com/read/29629953/utility-of-ber-ep4-and-moc-31-in-basaloid-skin-tumor-detection
#1
Pavandeep Gill, Christopher Naugler, Marie S Abi Daoud
Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions...
April 7, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29608228/old-docs-new-clicks-the-concert-%C3%A2-exam-and-the-aging-emergency-physician
#2
John H Burton, Jeffrey A Kline
In this issue of AEM, Marco et al., present their original research findings in the manuscript titled, Physician Age and Performance on the American Board of Emergency Medicine (ABEM) ConCert™ Examination.1 Marco et al. address two very controversial topics within our specialty. First, the matter of cognitive assessment(s) in the physician population, particularly the question of cognitive loss associated with age. Second is the role of ABEM certification process with particular emphasis on the ConCert™ examination in the continuous board maintenance process, known as Maintenance of Certification (MOC)...
April 2, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29599865/effect-of-compression-garments-on-physiological-responses-after-uphill-running
#3
Ivan Struhár, Michal Kumstát, Dagmar Moc Králová
Limited practical recommendations related to wearing compression garments for athletes can be drawn from the literature at the present time. We aimed to identify the effects of compression garments on physiological and perceptual measures of performance and recovery after uphill running with different pressure and distributions of applied compression. In a random, double blinded study, 10 trained male runners undertook three 8 km treadmill runs at a 6% elevation rate, with the intensity of 75% VO2max while wearing low, medium grade compression garments and high reverse grade compression...
March 2018: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29575314/3d-porous-cos2-hexadecahedron-derived-from-moc-towards-ultrafast-and-long-lifespan-lithium-storage
#4
Hanchi Wang, Zheng Cui, Chaoying Fan, Yanhong Shi, Siyu Liu, Xinglong Wu, Jingping Zhang
In this work, a novel hexadecahedron assembled by core-shell CoS2 particles@N-doped carbon (CoS2@NCH) is successfully prepared via the self-template method. The CoS2@NCH hybrid electrode delivers a high lithium-storage capacity of 778 mA h g-1 after 1000 cycles at a high current density of 1 A g-1, which is the longest cycle lifespan among the reported CoS2 anode materials in lithium ion batteries. Furthermore, CoS2@NCH hybrid electrode shows excellent rate capability with the discharge capacity of 220 mA h g-1 at extremely high current density of 20 A g-1 and a charge capacity of 649 mA h g-1 is restored when current density is back to 2 A g-1...
March 25, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29572431/a-gain-of-function-mutation-in-the-%C3%AE-9-nicotinic-acetylcholine-receptor-alters-medial-olivocochlear-efferent-short-term-synaptic-plasticity
#5
Carolina Wedemeyer, Lucas G Vattino, Marcelo J Moglie, Jimena Ballestero, Stéphane F Maison, Mariano N Di Guilmi, Julian Taranda, M Charles Liberman, Paul A Fuchs, Eleonora Katz, Ana Belén Elgoyhen
Gain control of the auditory system operates at multiple levels. Cholinergic medial olivocochlear (MOC) fibers originate in the brainstem and make synaptic contacts at the base of the outer hair cells (OHCs), the final targets of several feedback loops from the periphery and higher processing centers. Efferent activation inhibits OHC active amplification within the mammalian cochlea, through the activation of a calcium permeable α9α10 ionotropic cholinergic nicotinic receptor (nAChR), functionally coupled to calcium activated SK2 potassium channels...
March 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29567891/utility-of-moc-31-monoclonal-antibody-in-differentiating-metastatic-adenocarcinoma-cells-and-reactive-mesothelial-cells-in-effusion-cytology
#6
Bharat Patil, Vitaladevuni Shivkumar, Nitin Gangane
In effusion cytology, a clear distinction between reactive mesothelial cells and metastatic adenocarcinoma cells is sometimes challenging mainly due to similarities in the cytomorphological features. In such cases for definitive diagnosis, paraffin-embedded cell block examination and immunohistochemistry are helpful in making this distinction. MOC-31 is one of the proposed immunomarker for adenocarcinoma cells. We undertook to evaluate the role of MOC-31 as a marker for identifying adenocarcinoma cells in effusion specimen...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29559246/intrahepatic-cholangiocarcinoma-after-fontan-procedure-in-an-adult-with-visceral-heterotaxy
#7
Dehua Wang, Darren Marshall, Gruschen Veldtman, Anita Gupta, Andrew T Trout, Juan Villafane, Kevin Bove
Hepatic dysfunction, including development of hepatocellular carcinoma and other liver lesions has been increasingly reported following Fontan procedure for congenital heart disease. We report a unique case of intrahepatic cholangiocarcinoma 28 years after a Fontan procedure in a 31year old female with heterotaxy syndrome. The subcapsular mass-forming tumor was composed of poorly differentiated tumor cells arranged in small vague glandular or slit-lumen nests, and focally fused or anastomosing large trabecular patterns within the prominent fibrotic stroma...
March 15, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29544679/molecular-bases-of-the-poor-response-of-liver-cancer-to-chemotherapy
#8
Jose J G Marin, Oscar Briz, Elisa Herraez, Elisa Lozano, Maitane Asensio, Silvia Di Giacomo, Marta R Romero, Luis M Osorio-Padilla, Ana I Santos-Llamas, Maria A Serrano, Carolina Armengol, Thomas Efferth, Rocio I R Macias
A characteristic shared by most frequent types of primary liver cancer, i.e., hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) in adults, and in a lesser extent hepatoblastoma (HB) mainly in children, is their high refractoriness to chemotherapy. This is the result of synergic interactions among complex and diverse mechanisms of chemoresistance (MOC) in which more than 100 genes are involved. Pharmacological treatment, although it can be initially effective, frequently stimulates the expression of MOC genes, which results in the relapse of the tumor, usually with a more aggressive and less chemosensitive phenotype...
March 12, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29516388/the-american-board-of-internal-medicine-maintenance-of-certification-examination-and-state-medical-board-disciplinary-actions-a-population-cohort-study
#9
Furman S McDonald, Lauren M Duhigg, Gerald K Arnold, Ruth M Hafer, Rebecca S Lipner
BACKGROUND: Some have questioned whether successful performance in the American Board of Internal Medicine (ABIM) Maintenance of Certification (MOC) program is meaningful. The association of the ABIM Internal Medicine (IM) MOC examination with state medical board disciplinary actions is unknown. OBJECTIVE: To assess risk of disciplinary actions among general internists who did and did not pass the MOC examination within 10 years of initial certification. DESIGN: Historical population cohort study...
March 7, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29501436/beneficial-effect-of-nocturnal-oximetric-control-on-the-clinical-and-gasometric-situation-and-the-prognosis-of-patients-with-home-non-invasive-mechanical-ventilation
#10
Raúl Hidalgo Carvajal, Marcelino Sánchez Casado, Javier de Miguel-Díez, Encarnación López Gabaldón
INTRODUCTION AND OBJECTIVE: The effectiveness of home non-invasive mechanical ventilation (NIMV) is assessed by determining blood gas values in wakefulness, the evolution of their symptoms, and the monitoring of ventilation at night. The aim of our study is to evaluate whether defined values reached with outpatient monitoring by oximetry is related to the clinical, arterial gases and survival of a sample of patients with home NIMV. MATERIAL AND METHOD: Retrospective observational cohort study of a series of patients receiving home NIMV treatment for different causes...
February 28, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29491647/antioxidant-activity-of-the-essential-oil-and-its-major-terpenes-of-satureja-macrostema-moc-and-sess%C3%A3-ex-benth-briq
#11
Rafael Torres-Martínez, Yolanda Magdalena García-Rodríguez, Patricia Ríos-Chávez, Alfredo Saavedra-Molina, Joel Edmundo López-Meza, Alejandra Ochoa-Zarzosa, Rafael Salgado Garciglia
Background: The aim of this study was to investigate the in vitro antioxidant activity of Satureja macrostema (Moc. and Sessé ex Benth.) Briq. (Lamiaceae) essential oil, a Mexican medicinal plant known as nurite. Materials and Methods: Fresh aerial parts of S. macrostema plants cultivated in greenhouse for 3 months were subjected to hydrodistillation in a Clevenger apparatus to obtain essential oil. Volatile compounds were identified by gas chromatography (GC) and GC/mass spectrometry...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29483068/input-of-psychosocial-information-during-multidisciplinary-team-meetings-at-medical-oncology-departments-protocol-for-an-observational-study
#12
Melissa Horlait, Simon Van Belle, Mark Leys
BACKGROUND: Multidisciplinary team meetings (MDTMs) have become standard practice in oncology and gained the status of the key decision-making forum for cancer patient management. The current literature provides evidence that MDTMs are achieving their intended objectives but there are also indications to question the positive impact of MDTMs in oncology settings. For cancer management to be patient-centered, it is crucial that medical information as well as psychosocial aspects-such as the patients' living situation, possible family problems, patients' mental state, and patients' perceptions and values or preferences towards treatment or care-are considered and discussed during MDTMs...
February 26, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29438528/maintenance-of-certification-perceptions-and-attitudes-of-neurosurgeons
#13
Maya A Babu, Linda M Liau, E Sander Connolly, Fredric B Meyer
Assuring clinical competence throughout the career of a neurosurgeon is of paramount importance for patient safety. We present the first comprehensive survey of all neurosurgeons board certified through the American Board of Neurological Surgery (ABNS) to evaluate perceptions of Maintenance of Certification (MOC). We administered a validated, online, confidential survey to 4899 neurosurgeons (2435 ABNS diplomates participating in MOC, 1440 diplomates certified prior to 1999 [time-unlimited certificates], and 1024 retired diplomates)...
February 9, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29435766/assessment-of-soil-organic-carbon-fractions-and-carbon-management-index-under-different-land-use-types-in-olesharo-catchment-narok-county-kenya
#14
Bernice M Sainepo, Charles K Gachene, Anne Karuma
BACKGROUND: The changes in land use and land cover have a strong effect on the total soil organic carbon, its fractions and its overall soil health. This study carried out in Olesharo Catchment, Kenya, was to quantify the differences in total organic carbon (TOC), particulate organic carbon (POC), mineral organic carbon (MOC) and carbon management index (CMI) among four land use types: grasslands, shrublands, agricultural lands and barelands. It was also purported to evaluate the use of CMI as an indicator for soil degradation or improvement in response to land use and land cover changes...
February 12, 2018: Carbon Balance and Management
https://www.readbyqxmd.com/read/29429591/early-stage-mucinous-ovarian-cancer-a-review
#15
Erin K Crane, Jubilee Brown
Mucinous ovarian carcinomas (MOCs) are an uncommon subset of epithelial neoplasms, both clinically and molecularly distinct from other ovarian cancers. Pathologic diagnosis proves challenging, and metastatic disease from other sites-especially the digestive tract-must be excluded. Fortunately, most patients are diagnosed at an early stage of disease and often present with large, unilateral adnexal masses. Survival for patients with stage IA disease approaches over 90%, and surgery alone is sufficient. Patients with stage IB-II disease should receive adjuvant treatment but the specific regimen is controversial...
February 8, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29413777/advanced-conservative-treatment-of-complete-acute-rupture-of-the-lateral-ankle-ligaments-verifying-by-stabilometry
#16
Jana Řezaninová, Luboš Hrazdira, Dagmar Moc Králová, Zdeněk Svoboda, Azriel Benaroya
BACKGROUND: The aim of this study was to investigate the result of the specific conservative treatment of acute lateral ankle ligaments rupture and verify the effect of this therapy by stabilometry. METHODS: 17 young athletes were examined after acute lateral ankle sprain (grade III). Diagnosis was based on musculoskeletal ultrasound examinations. Pressure plate evaluated postural stability after conservative treatment at regular intervals during 1year. RESULTS: There were no significant differences in postural stability in double-leg stance between limbs...
February 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29391459/optimising-the-glaucoma-signal-noise-ratio-by-mapping-changes-in-spatial-summation-with-area-modulated-perimetric-stimuli
#17
Lindsay Rountree, Pádraig J Mulholland, Roger S Anderson, David F Garway-Heath, James E Morgan, Tony Redmond
Identification of glaucomatous damage and progression by perimetry are limited by measurement and response variability. This study tested the hypothesis that the glaucoma damage signal/noise ratio is greater with stimuli varying in area, either solely, or simultaneously with contrast, than with conventional stimuli varying in contrast only (Goldmann III, GIII). Thirty glaucoma patients and 20 age-similar healthy controls were tested with the Method of Constant Stimuli (MOCS). One stimulus modulated in area (A), one modulated in contrast within Ricco's area (CR), one modulated in both area and contrast simultaneously (AC), and the reference stimulus was a GIII, modulating in contrast...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29381367/synergistic-effects-of-c-%C3%AE-moc-and-ag-for-efficient-oxygen-reduction-reaction
#18
Lujie Cao, Pengpeng Tao, Minchan Li, Fucong Lyu, Zhenyu Wang, Sisi Wu, Wenxi Wang, Yifeng Huo, Li Huang, Zhouguang Lu
It remains challenging to prepare highly active and stable catalysts from earth-abundant elements for the oxygen reduction reaction (ORR). Herein we report a facile method to synthesize cost-effective heterogeneous C/α-MoC/Ag electrocatalysts. Rotating disc electrode (RDE) experiments revealed that the obtained C/α-MoC/Ag exhibited much superior catalytic performance for ORR than that of C/Ag, C/α-MoC, or even the conventional Pt/C. First-principles calculations indicated that the enhanced activity could be attributed to the efficient synergistic effects between Ag and α-MoC/C by which the energy barrier for O2 dissociation has been substantially reduced...
January 30, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29376418/growth-and-liver-histology-of-channa-punctatus-exposed-to-a-common-biofertilizer
#19
S Nath, V Matozzo, D Bhandari, C Faggio
Mustard oil cake (MOC) is widely used as biofertilizer in the field of agriculture and aquaculture. Channa punctatus was exposed to 0.42 g.L-1 sublethal concentration for 4, 7, 14, 21 and 28 days. Due to such exposure, body growth and histological changes in liver were observed. It was revealed that weight, length and breadth of fish were gradually increased with the days of exposure in compare to control fish, whereas, liver showed an increase in sinusoidal space and lipidosis during early days, followed by a recovery from the stress of MOC on the 28th day...
January 28, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29352112/direct-cell-cell-contact-between-mature-osteoblasts-and-osteoclasts-dynamically-controls-their-functions-in-vivo
#20
Masayuki Furuya, Junichi Kikuta, Sayumi Fujimori, Shigeto Seno, Hiroki Maeda, Mai Shirazaki, Maki Uenaka, Hiroki Mizuno, Yoriko Iwamoto, Akito Morimoto, Kunihiko Hashimoto, Takeshi Ito, Yukihiro Isogai, Masafumi Kashii, Takashi Kaito, Shinsuke Ohba, Ung-Il Chung, Alexander C Lichtler, Kazuya Kikuchi, Hideo Matsuda, Hideki Yoshikawa, Masaru Ishii
Bone homeostasis is regulated by communication between bone-forming mature osteoblasts (mOBs) and bone-resorptive mature osteoclasts (mOCs). However, the spatial-temporal relationship and mode of interaction in vivo remain elusive. Here we show, by using an intravital imaging technique, that mOB and mOC functions are regulated via direct cell-cell contact between these cell types. The mOBs and mOCs mainly occupy discrete territories in the steady state, although direct cell-cell contact is detected in spatiotemporally limited areas...
January 19, 2018: Nature Communications
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