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https://www.readbyqxmd.com/read/27919853/endoscopic-bilateral-stent-in-stent-placement-for-malignant-hilar-obstruction-using-a-large-cell-type-stent
#1
Jin Myung Park, Sang Hyub Lee, Kwang Hyun Chung, Dong Kee Jang, Ji Kon Ryu, Yong-Tae Kim, Jae Min Lee, Woo Hyun Paik
BACKGROUND: Bilateral stent-in-stent (SIS) self-expandable metal stent placement is technically challenging for palliation of unresectable malignant hilar obstruction. In the SIS technique, the uniform large cell type biliary stent facilitates contralateral stent deployment through the mesh of the first metallic stent. This study aimed to assess the technical success and clinical effectiveness of this technique with a uniform large cell type biliary stent. METHODS: Thirty-one patients who underwent bilateral SIS placement using a large cell type stent were reviewed retrospectively...
December 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27918135/star-polymocs-with-diverse-structures-dynamics-and-functions-by-three-component-assembly
#2
Yufeng Wang, Yuwei Gu, Eric G Keeler, Jiwon V Park, Robert G Griffin, Jeremiah A Johnson
We report star polymer metal-organic cage (polyMOC) materials whose structures, mechanical properties, functionalities, and dynamics can all be precisely tailored through a simple three-component assembly strategy. The star polyMOC network is composed of tetra-arm star polymers functionalized with ligands on the chain ends, small molecule ligands, and palladium ions; polyMOCs are formed via metal-ligand coordination and thermal annealing. The ratio of small molecule ligands to polymer-bound ligands determines the connectivity of the MOC junctions and the network structure...
December 5, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27914370/concurrent-measures-of-contralateral-suppression-of-transient-evoked-otoacoustic-emissions-and-of-auditory-steady-state-responses
#3
Ian B Mertes, Marjorie R Leek
Contralateral suppression of otoacoustic emissions (OAEs) is frequently used to assess the medial olivocochlear (MOC) efferent system, and may have clinical utility. However, OAEs are weak or absent in hearing-impaired ears, so little is known about MOC function in the presence of hearing loss. A potential alternative measure is contralateral suppression of the auditory steady-state response (ASSR) because ASSRs are measurable in many hearing-impaired ears. This study compared contralateral suppression of both transient-evoked otoacoustic emissions (TEOAEs) and ASSRs in a group of ten primarily older adults with either normal hearing or mild sensorineural hearing loss...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27896831/anomerization-reaction-of-bare-and-microhydrated-d-erythrose-via-explicitly-correlated-coupled-cluster-approach-two-water-molecules-are-optimal
#4
Marek Szczepaniak, Jerzy Moc
We present a comprehensive benchmark computational study which has explored a complete path of the anomerization reaction of bare d-erythrose involving a pair of the low-energy α- and β-furanose anomers, the former of which was observed spectroscopically (Cabezas et al., Chem. Commun. 2013, 49, 10826). We find that the ring opening of the α-anomer yields the most stable open-chain tautomer which step is followed by the rotational interconversion of the open-chain rotamers and final ring closing to form the β-anomer...
November 29, 2016: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/27889016/is-it-necessary-to-perform-routine-appendectomy-for-mucinous-ovarian-neoplasms-a-retrospective-study-and-meta-analysis
#5
REVIEW
Aoshuang Cheng, Minghao Li, Margaux J Kanis, Ying Xu, Qing Zhang, Baoxia Cui, Jie Jiang, YouZhong Zhang, Xingsheng Yang, Beihua Kong
OBJECTIVES: To evaluate whether routine appendectomy is necessary in all patients with mucinous borderline ovarian tumor (mBOT) or mucinous ovarian cancer (MOC) who undergo gynecologic surgery. METHODS: The database of Qilu Hospital was searched for women who underwent appendectomy in a primary surgery for an ovarian tumor between June 2005 and June 2015 and whose final diagnosis was mBOT, MOC or primary appendiceal tumor. A retrospective review was performed, as well as a meta-analysis of the literature to further validate the findings...
November 23, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27886943/use-of-ehealth-technologies-to-enable-the-implementation-of-musculoskeletal-models-of-care-evidence-and-practice
#6
REVIEW
Helen Slater, Blake F Dear, Mark A Merolli, Linda C Li, Andrew M Briggs
Musculoskeletal (MSK) conditions are the second leading cause of morbidity-related burden of disease globally. EHealth is a potentially critical factor that enables the implementation of accessible, sustainable and more integrated MSK models of care (MoCs). MoCs serve as a vehicle to drive evidence into policy and practice through changes at a health system, clinician and patient level. The use of eHealth to implement MoCs is intuitive, given the capacity to scale technologies to deliver system and economic efficiencies, to contribute to sustainability, to adapt to low-resource settings and to mitigate access and care disparities...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27886941/management-of-musculoskeletal-pain-in-a-compensable-environment-implementation-of-helpful-and-unhelpful-models-of-care-in-supporting-recovery-and-return-to-work
#7
REVIEW
Darren Beales, Kal Fried, Michael Nicholas, Fiona Blyth, Damien Finniss, G Lorimer Moseley
Models of Care (MoCs) for injured workers in the compensation environment recommend adoption of biopsychosocial management approaches. Still, widespread dominance of biomedical constructs at the system, organisational and individual levels of the compensation system prevails, contributing to suboptimal management practices and outcomes for injured workers. Efforts to implement contemporary MoCs in the compensation environment show some promise in improving outcomes. Areas of promise at the organisational level, particularly in the workplace, and at the system level are discussed...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27886939/development-and-implementation-of-models-of-care-for-musculoskeletal-conditions-in-middle-income-and-low-income-asian-countries
#8
REVIEW
Keith K Lim, Madelynn Chan, Sandra Navarra, Syed Atiqul Haq, Chak Sing Lau
This chapter discusses the challenges faced in the development and implementation of musculoskeletal (MSK) Models of Care (MoCs) in middle-income and low-income countries in Asia and outlines the components of an effective MoC for MSK conditions. Case studies of four such countries (The Philippines, Malaysia, Bangladesh and Myanmar) are presented, and their unique implementation issues are discussed. The success experienced in one high-income country (Singapore) is also described as a comparison. The Community Oriented Program for Control of Rheumatic Diseases (COPCORD) project and the role of Asia Pacific League of Associations for Rheumatology (APLAR), a professional body supporting MoC initiatives in this region, are also discussed...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27886937/models-of-care-for-musculoskeletal-health-moving-towards-meaningful-implementation-and-evaluation-across-conditions-and-care-settings
#9
REVIEW
Andrew M Briggs, Madelynn Chan, Helen Slater
Models of Care (MoCs) are increasingly recognised as a system-level enabler to translate evidence for 'what works' into policy and, ultimately, clinical practice. MoCs provide a platform for a reform agenda in health systems by describing not only what care to deliver but also how to deliver it. Given the enormous burden of disease associated with musculoskeletal (MSK) conditions, system-level (macro) reform is needed to drive downstream improvements in MSK healthcare - at the health service (meso) level and at the clinical interface (micro) level...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27876290/response-of-mixed-methanotrophic-consortia-to-different-methane-to-oxygen-ratios
#10
K Chidambarampadmavathy, O P Karthikeyan, R Huerlimann, G E Maes, K Heimann
Methane (CH4) and oxygen (air) concentrations affect the CH4 oxidation capacity (MOC) and mixed methanotrophic community structures in compost (fresh) and landfill (age old) top cover soils. A change in the mixed methanotrophic community structure in response has implications for landfill CH4 bio-filter remediation and possible bio-product outcomes (i.e., fatty acid methyl esters (FAME) content and profiles and polyhydroxybutyrate (PHB) contents). Therefore the study aimed to evaluate the effect of variable CH4 to oxygen ratios (10-50% CH4 in air) on mixed methanotrophic community structures enriched from landfill top cover (LB) and compost soils (CB) and to quantify flow on impacts on MOC, total FAME contents and profiles, and PHB accumulation...
November 18, 2016: Waste Management
https://www.readbyqxmd.com/read/27860146/incidence-of-lymph-node-metastases-in-clinical-early-stage-mucinous-and-seromucinous-ovarian-carcinoma-a-retrospective-cohort-study
#11
Joam van Baal, K K Van de Vijver, S B Coffelt, V van der Noort, W J van Driel, G G Kenter, M R Buist, Car Lok
OBJECTIVE: The use of lymph node sampling during staging procedures in clinical early-stage mucinous ovarian carcinoma (MOC) is an ongoing matter of debate. Furthermore, the incidence of lymph node metastases (LNM) in MOC in relation to tumour grade (G) is unknown. We aimed to determine the incidence of LNM in clinical early-stage MOC per tumour grade. DESIGN: Retrospective study with data from the Dutch Pathology Registry (PALGA). SETTING: The Netherlands, 2002-2012...
November 16, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27836719/effects-of-the-dietary-supplementation-of-mixed-probiotic-spores-of-bacillus-amyloliquefaciens-54a-and-bacillus-pumilus-47b-on-growth-innate-immunity-and-stress-responses-of-striped-catfish-pangasianodon-hypophthalmus
#12
Ho Thi Truong Thy, Nguyen Nhu Tri, Ong Moc Quy, Korntip Kannika, Sasimanas Unajak, Nontawith Areechon
The study used the mixed probiotics of Bacillus amyloliquefaciens 54A and B. pumilus 47B isolated from striped catfish (Pangasianodon hypophthalmus) intestine aiming to stimulate growth performance, innate immunity, stress tolerance of striped catfish. The average weight gain (AWG), specific growth rate (SGR), and feed conversion ratio (FCR) were analyzed after fish were fed the mixture of probiotics (B. amyloliquefaciens 54A and B. pumilus 47B) at concentrations of 1 × 10(8), 3 × 10(8), and 5 × 10(8) CFU g(-1) feed for 90 days...
November 8, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27808515/the-discovery-of-ruzasvir-mk-8408-a-potent-pan-genotype-hcv-ns5a-inhibitor-with-optimized-activity-against-common-resistance-associated-polymorphisms
#13
Ling Tong, Wensheng Yu, Lei Chen, Oleg Selyutin, Michael P Dwyer, Anilkumar Gopinadhan Nair, Robert Mazzola, Jae-Hun Kim, Deyou Sha, Jingjun Yin, Rebecca Tamra Ruck, Ian W Davies, Bin Hu, Bin Zhong, Jinglai Hao, Tao Ji, Shuai Zan, Rong Liu, Sony Agrawal, Ellen Xia, Stephanie Curry, Patricia Mcmonagle, Karin Bystol, Frederick Lahser, Donna Carr, Laura Rokosz, Paul Ingravallo, Shiying Chen, Kung-I Feng, Mark Cartwright, Ernest Asante-Appiah, Joseph A Kozlowski
We describe the research that led to the discovery of compound 40 (ruzasvir, MK-8408), a pan-genotypic HCV nonstructural protein 5A (NS5A) inhibitor with a "flat" GT1 mutant profile. This NS5A inhibitor contains a unique tetracyclic indole core, while maintaining the imidazole-proline-valine Moc motifs of our previous NS5A inhibitors. Compound 40 is currently in early clinical trials and is under evaluation as part of an all-oral DAA regimen for the treatment of chronic HCV infection..
November 3, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27802029/an-integrative-folate-based-metal-complex-nanotube-as-a-potent-antitumor-nanomedicine-as-well-as-an-efficient-tumor-targeted-drug-carrier
#14
Lixiang Liu, Bingxia Li, Qiyan Wang, Zhipeng Dong, Hongmei Li, Qiaomei Jin, Hao Hong, Jian Zhang, Yue Wang
Metal-organic complexes (MOCs) are emerging developing functional materials, the different categories of metal ions and organic biomolecules provide great possibilities for the morphologies, sizes and properties of the products. Enlightened by the previous works of folate-nickel nanotubes (FA-Ni NTs), herein, a series of metal ions are tested to coordinate with folate (FA) by solvothermal method, among which folate-cobalt (2+) complex is formed to be a scaffold for the nanotube with the length of 150-500 nm and inner diameter of 6-11 nm, while the other metal ions fail...
November 1, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27798720/electrically-evoked-medial-olivocochlear-efferent-effects-on-stimulus-frequency-otoacoustic-emissions-in-guinea-pigs
#15
Maria A Berezina-Greene, John J Guinan
Stimulus frequency otoacoustic emissions (SFOAEs) are produced by cochlear irregularities reflecting energy from the peak region of the traveling wave (TW). Activation of medial olivocochlear (MOC) efferents reduces cochlear amplification and otoacoustic emissions (OAEs). In other OAEs, MOC activation can produce enhancements. The extent of MOC enhancements of SFOAEs has not been previously studied. In anesthetized guinea pigs, we electrically stimulated MOC fibers and recorded their effects on SFOAEs. MOC stimulation mostly inhibited SFOAEs but sometimes enhanced them...
October 31, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27794300/effects-of-age-and-hearing-loss-on-overshoot
#16
Skyler G Jennings, Jayne B Ahlstrom, Judy R Dubno
The detection of a brief, sinusoidal probe in a long broadband, simultaneous masker improves as the probe is delayed from the masker's onset. This improvement ("overshoot") may be mediated by a reduction in cochlear amplifier gain over the timecourse of the masker via the medial olivocochlear (MOC) reflex. Overshoot was measured in younger adults with normal hearing and in older adults with normal and impaired hearing to test the hypothesis that aging and cochlear hearing loss result in abnormal overshoot, consistent with changes in certain structures along the MOC pathway...
October 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27774396/calix-like-metal-organic-complex-for-high-sensitivity-x-ray-induced-photochromism
#17
Hao Zhang, Xintao Wu
Metal-organic complexes (MOCs) as promising candidates for directly visual X-ray detection at room temperature are rare and discovered unexpectedly, even though every crystalline material needs X-ray diffraction studies. Here, we report a rational strategy of mimicking host-guest system for developing high-sensitive X-ray-induced photochromic materials. Two resulting calix-like metal-organic complexes (cMOC-1 and cMOC-2) were prepared by encapsulating the electron-capturing "guest" into the cavity of calix-like electron-donating "host...
April 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27756821/dynamic-interplay-between-nucleoid-segregation-and-genome-integrity-in-chlamydomonas-chloroplasts
#18
Masaki Odahara, Yusuke Kobayashi, Toshiharu Shikanai, Yoshiki Nishimura
The chloroplast (cp) genome is organized as nucleoids that are dispersed throughout the cp stroma. Previously, a cp homolog of bacterial recombinase RecA (cpRECA) was shown to be involved in the maintenance of cp genome integrity by repairing damaged chloroplast DNA and by suppressing aberrant recombination between short dispersed repeats in the moss Physcomitrella patens Here, overexpression and knockdown analysis of cpRECA in the green alga Chlamydomonas reinhardtii revealed that cpRECA was involved in cp nucleoid dynamics as well as having a role in maintaining cp genome integrity...
December 2016: Plant Physiology
https://www.readbyqxmd.com/read/27730085/women-in-india-with-gestational-diabetes-mellitus-strategy-wings-methodology-and-development-of-model-of-care-for-gestational-diabetes-mellitus-wings-4
#19
Arivudainambi Kayal, Viswanathan Mohan, Belma Malanda, Ranjit Mohan Anjana, Balaji Bhavadharini, Manni Mohanraj Mahalakshmi, Kumar Maheswari, Ram Uma, Ranjit Unnikrishnan, Gunasekaran Kalaiyarasi, Lyudmil Ninov, Anne Belton
AIM: The Women In India with GDM Strategy (WINGS) project was conducted with the aim of developing a model of care (MOC) suitable for women with gestational diabetes mellitus (GDM) in low- and middle-income countries. METHODOLOGY: The WINGS project was carried out in Chennai, Southern India, in two phases. In Phase I, a situational analysis was conducted to understand the practice patterns of health-care professionals and to determine the best screening criteria through a pilot screening study...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27715043/adsorption-dissociation-and-dehydrogenation-of-water-monomer-and-water-dimer-on-the-smallest-3d-aluminum-particle-the-o-h-dissociation-barrier-disappears-for-the-dimer
#20
Jerzy Moc
We present a detailed mechanistic study on the interaction and reaction of water monomer and water dimer with the smallest 3D aluminum particle (Al6) by employing density functional and explicitly correlated coupled cluster CCSD(T)-F12 theories, the latter with the cc-pVnZ-F12 (n=T,Q) basis sets. The water adsorption, dissociation and dehydrogenation is investigated. For the water monomer reaction, where core-valence correlation, Kohn-Sham reference and an extrapolation to the complete basis set limit is considered, our coupled cluster results suggest the O-H dissociation barrier of at least 2 kcal/mol...
October 7, 2016: Journal of Physical Chemistry. A
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