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https://www.readbyqxmd.com/read/29028636/effects-and-unforeseen-consequences-of-accessing-references-on-a-maintenance-of-certification-examination-findings-from-a-national-study
#1
Richard A Feinberg, Daniel Jurich, Lauren M Foster
PURPOSE: Increasing criticism of maintenance of certification (MOC) examinations has prompted certifying boards to explore alternative assessment formats. The purpose of this study was to examine the effect of allowing test takers to access reference material while completing their MOC Part III standardized examination. METHOD: Item response data were obtained from 546 physicians who completed a medical subspecialty MOC examination between 2013 and 2016. To investigate if accessing references was related to better performance, an analysis of covariance was conducted on the MOC examination scores with references (access or no access) as the between-groups factor and scores from the physicians' initial certification examination as a covariate...
October 12, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29024755/performance-of-pediatric-rehabilitation-medicine-candidates-on-the-subspecialty-board-certification-examination-from-2003-2015
#2
Sherilyn W Driscoll, Teresa L Massagli, Mary A McMahon, Mikaela M Raddatz, David W Pruitt, Kevin P Murphy
BACKGROUND: Pediatric Rehabilitation Medicine (PRM) physicians enter the field via several pathways. It is unknown if different training pathways impact performance on the American Board of Physical Medicine and Rehabilitation (ABPMR) PRM Examination and Maintenance of Certification (MOC) Examination. OBJECTIVES: To describe the exam performance of candidates on the ABPMR PRM Examination according to their type of training (physiatrists with a clinical PRM focus, accredited or unaccredited fellowship training, separate pediatric and PM&R residencies or combined Peds/PM&R residencies) and to compare candidates' performance on the PRM Examination with their initial ABPMR certification and MOC Examinations...
October 9, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29024544/squamous-cell-carcinoma-in-serous-effusions-avoiding-pitfalls-in-this-rare-encounter
#3
Christopher LePhong, Elizabeth W Hubbard, Stuart Van Meter, Laurentia Nodit
BACKGROUND: With advent of personalized medicine, precise classification of malignant tumors becomes essential. Squamous cell carcinoma (SCC) is rarely found in serous effusions and has morphologic and immunohistochemical (IHC) overlap with other neoplasms. METHODS: 17-year review identified 49 fluids from 26 patients where SCC was recognized. RESULTS: SCC was more frequent in pleural fluid (84%) and rare in other effusions. Lung SCC was common (65%), followed by head and neck (16%), with other origins less represented...
October 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28994846/3d-self-assembly-of-ultrafine-molybdenum-carbide-confined-in-n-doped-carbon-nanosheets-for-efficient-hydrogen-production
#4
Haiqing Wang, Xiaobin Xu, Bing Ni, Haoyi Li, Wei Bian, Xun Wang
Electrochemical water splitting has been intensively pursued as a promising approach to produce clean and sustainable hydrogen fuel. However, the lack of low-cost and high-performance electrocatalysts for the hydrogen evolution reaction (HER) hinders the large-scale application. Herein, we have rationally designed and synthesized 3D self-assembly architectures assembled from ultrafine MoC nanoparticles (0D) uniformly embedded within N-doped carbon nanosheets (2D) for the HER via a simple protocol. The well-organized 3D nanostructures are composed of very small MoC nanocrystallites (<2 nm) and free-stretching conductive carbon nanosheets with high specific surface areas and abundant mesopores, which can expose more active sites and facilitate electron/ion transport pathways...
October 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28984895/new-balance-new-beginning
#5
Joey Berlin
Following the passage of TMA-supported legislation to loosen maintenance of certification (MOC) requirements, Texas is now a national leader in reducing the onerousness of MOC on physicians. What will the new law do once it takes effect at the beginning of 2018, and what could it do to keep more physicians in practice?
October 1, 2017: Texas Medicine
https://www.readbyqxmd.com/read/28939108/differential-response-to-doxorubicin-in-breast-cancer-subtypes-simulated-by-a-microfluidic-tumor-model
#6
Altug Ozcelikkale, Kyeonggon Shin, Victoria Noe-Kim, Bennett D Elzey, Zizheng Dong, Jian-Ting Zhang, Kwangmeyung Kim, Ick Chan Kwon, Kinam Park, Bumsoo Han
Successful drug delivery and overcoming drug resistance are the primary clinical challenges for management and treatment of cancer. The ability to rapidly screen drugs and delivery systems within physiologically relevant environments is critically important; yet is currently limited due to lack of appropriate tumor models. To address this problem, we developed the Tumor-microenvironment-on-chip (T-MOC), a new microfluidic tumor model simulating the interstitial flow, plasma clearance, and transport of the drug within the tumor...
September 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28938186/electrochemiluminescence-resonance-energy-transfer-system-between-gnrs-and-ru-bpy-3-2-application-in-magnetic-aptasensor-for-%C3%AE-amyloid
#7
Hong Ke, Haifeng Sha, Yinfang Wang, Weiwei Guo, Xin Zhang, Zhiming Wang, Chusen Huang, Nengqin Jia
Electrochemiluminescent (ECL) assay has gradually drawn increasing interest in the biomedical analysis. This paper proposed a new methodology for ultrasensitive and facile detection of Alzheimer's disease marker β-amyloid (Aβ) by fabricating a sandwich-type ECL sensing platform. Herein, electrochemiluminescence resonance energy transfer (ECL-RET) was employed to determine Aβ concentration, which can be attributed to the quenching effect from RET between Ru(bpy)3(2+) and gold nanorods (GNRs) acting as ECL-RET electron donor and acceptor, respectively...
September 14, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28934882/development-of-a-cartilage-shear-damage-model-to-investigate-the-impact-of-surface-injury-on-chondrocytes-and-extracellular-matrix-wear
#8
Robert L Trevino, Carol A Pacione, Anne-Marie Malfait, Susan Chubinskaya, Markus A Wimmer
Background Many i n vitro damage models investigate progression of cartilage degradation after a supraphysiologic, compressive impact at the surface and do not model shear-induced damage processes. Models also neglect the response to uninterrupted tribological stress after damage. It was hypothesized that shear-induced removal of the superficial zone would accelerate matrix degradation when damage was followed by continued load and articulation. Methods Bovine cartilage underwent a 5-day test. Shear-damaged samples experienced 2 days of damage induction with articulation against polyethylene and then continued articulation against cartilage (CoC), articulation against metal (MoC), or rest as free-swelling control (FSC)...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28933002/mepolizumab-for-treating-severe-eosinophilic-asthma-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#9
REVIEW
Iñigo Bermejo, Matt Stevenson, Katy Cooper, Sue Harnan, Jean Hamilton, Mark Clowes, Christopher Carroll, Tim Harrison, Shironjit Saha
As part of its single technology appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited the company (GlaxoSmithKline) that manufactures mepolizumab (Nucala(®)) to submit evidence on the clinical and cost effectiveness of mepolizumab for the treatment of severe eosinophilic asthma. The School of Health and Related Research Technology Appraisal Group (ScHARR-TAG) at the University of Sheffield was commissioned to act as the independent evidence review group (ERG). The ERG produced a review of the evidence for the clinical and cost effectiveness of mepolizumab as add-on to standard of care (SoC) compared with SoC and omalizumab, based upon the company's submission to NICE...
September 20, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28923838/syngeneic-mouse-models-of-oral-cancer-are-effectively-targeted-by-anti-cd44-based-nir-pit
#10
Tadanobu Nagaya, Yuko Nakamura, Shuhei Okuyama, Fusa Ogata, Yasuhiro Maruoka, Peter L Choyke, Clint Alen, Hisataka Kobayashi
Oral cavity squamous cell carcinoma (OSCC) is considered one of the most aggressive subtypes of cancer. Anti-CD44 monoclonal antibodies (mAbs) are a potential therapy against CD44 expressing OSCC, however, to date the therapeutic effects have been disappointing. Here, a new cancer treatment is described, near-infrared photoimmunotherapy (NIR-PIT), that uses anti-CD44 mAbs conjugated to the photoabsorber, IR700DX. This conjugate is injected into mice harboring one of three CD44 expressing syngeneic murine oral cancer cell (MOC) lines, MOC1 (immunogenic), MOC2 mKate2 (moderately immunogenic), and MOC2-luc (poorly immunogenic)...
September 18, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28916288/anti-apoptotic-and-moderate-anti-inflammatory-effects-of-berberine-in-sulfur-mustard-exposed-keratinocytes
#11
Simon Lang, Tanja Popp, Christian Silvester Kriegs, Annette Schmidt, Frank Balszuweit, Georg Menacher, Kai Kehe, Horst Thiermann, Thomas Gudermann, Dirk Steinritz
Skin affections after sulfur mustard (SM) exposure include erythema, blister formation and severe inflammation. An antidote or specific therapy does not exist. Anti-inflammatory compounds as well as substances counteracting SM-induced cell death are under investigation. In this study, we investigated the benzylisoquinoline alkaloide berberine (BER), a metabolite in plants like berberis vulgaris, which is used as herbal pharmaceutical in Asian countries, against SM toxicity using a well-established in vitro approach...
September 12, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28885839/co2-stimuli-responsive-injectable-block-copolymer-hydrogels-cross-linked-by-discrete-organoplatinum-ii-metallacycles-via-stepwise-post-assembly-polymerization
#12
Wei Zheng, Guang Yang, Nannan Shao, Li-Jun Chen, Bo Ou, Shu-Ting Jiang, Guosong Chen, Hai-Bo Yang
Supramolecular polymeric gels cross-linked by well-defined, discrete metal-organic macrocycles (MOMs) or metal-organic cages have become a prevailing topic within the field of supramolecular self-assembly. However, the realization of supramolecular polymeric hydrogels cross-linked by discrete organometallic architectures with good biocompatibility is still a great challenge. Herein, we present the successful preparation of CO2 stimuli-responsive, injectable block copolymer hydrogels cross-linked by discrete organoplatinum(II) metallacycles...
September 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28884807/co-creation-by-the-abim-geriatric-medicine-board-and-the-ags-helping-move-geriatrics-forward
#13
Bruce Leff, Nancy E Lundjeberg, Sharon A Brangman, Joyce Dubow, Sharon Levine, Melissa Morgan-Gouveia, Jeffrey Schlaudecker, Lorna Lynn, Furman S McDonald
The American board of internal medicine (ABIM) establishes standards for physicians. The American geriatrics society (AGS) is a not-for-profit membership organization of nearly 6,000 health professionals devoted to improving the health, independence, and quality of life of all older people. Beginning in 2013, ABIM redesigned its governance structure, including the role of the specialty boards. Specialty boards are charged with responsibilities for oversight in four main areas: (1) the assessments used in initial certification and maintenance of certification (MOC); (2) medical knowledge self-assessment and practice assessment in the specialty; (3) building relationships with relevant professional societies and other organizational stakeholders; and (4) issues related to training requirements for initial certification eligibility within the specialty...
October 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28864623/from-the-abnm-updates-on-moc-part-3
#14
Leonie Gordon
No abstract text is available yet for this article.
September 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28859724/meeting-acgme-and-abms-quality-improvement-requirements-in-a-sleep-medicine-fellowship-program
#15
Anita Valanju Shelgikar, Cindy Priddy, R Van Harrison
STUDY OBJECTIVES: To describe a sustainable program of teaching and implementing quality improvement (QI) in a 12-month sleep medicine fellowship. METHODS: We created a QI curriculum based on Accreditation Council for Graduate Medical Education (ACGME) and American Board of Medical Specialty (ABMS) Part IV Maintenance of Certification (MOC) requirements for QI. Two program faculty with prior QI training volunteered to mentor fellows. Our institution's central QI office houses QI experts who teach QI across the health system...
August 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28843833/strain-specific-differences-in-the-development-of-neuronal-excitability-in-the-mouse-ventral-nucleus-of-the-trapezoid-body
#16
James L Sinclair, Margaret Barnes-Davies, Conny Kopp-Scheinpflug, Ian D Forsythe
This investigation compared the development of neuronal excitability in the ventral nucleus of the trapezoid body (VNTB) between two strains of mice with differing progression rates for age-related hearing loss. In contrast to CBA/Ca (CBA) mice, the C57BL/6J (C57) strain are subject to hearing loss from a younger age and are more prone to damage from sound over-exposure. Higher firing rates in the medial olivocochlear system (MOC) are associated with protection from loud sounds and these cells are located in the VNTB...
August 18, 2017: Hearing Research
https://www.readbyqxmd.com/read/28822244/new-insights-into-the-enhanced-performance-of-high-solid-anaerobic-digestion-with-dewatered-sludge-by-thermal-hydrolysis-organic-matter-degradation-and-methanogenic-pathways
#17
Sisi Chen, Ning Li, Bin Dong, Wentao Zhao, Lingling Dai, Xiaohu Dai
Two lab-scale high solid anaerobic digesters fed with untreated sludge (R1) and thermally hydrolyzed sludge (R2) were operated to investigate the influence of thermal hydrolysis pretreatment (THP) on the degradation of individual macromolecular organic components (MOCs), as well as the functional and metabolic responses of microbes during anaerobic digestion (AD). The degradation of MOCs was improved by THP at different rates, in which improved degradation of proteins (by 49.0%) and hemicelluloses (by 25.0%) were the main factors contributing to the increase in volatile solids (VS) reduction...
August 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28816912/distance-learning-adhd-quality-improvement-in-primary-care-a-cluster-randomized-trial
#18
Alexander G Fiks, Stephanie L Mayne, Jeremy J Michel, Jeffrey Miller, Manju Abraham, Andrew Suh, Abbas F Jawad, James P Guevara, Robert W Grundmeier, Nathan J Blum, Thomas J Power
OBJECTIVE: To evaluate a distance-learning, quality improvement intervention to improve pediatric primary care provider use of attention-deficit/hyperactivity disorder (ADHD) rating scales. METHODS: Primary care practices were cluster randomized to a 3-part distance-learning, quality improvement intervention (web-based education, collaborative consultation with ADHD experts, and performance feedback reports/calls), qualifying for Maintenance of Certification (MOC) Part IV credit, or wait-list control...
August 9, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28806791/effect-of-access-to-an-electronic-medical-resource-on-performance-characteristics-of-a-certification-examination-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Rebecca S Lipner, Bradley G Brossman, Kelli M Samonte, Steven J Durning
Background: Electronic resources are increasingly used in medical practice. Their use during high-stakes certification examinations has been advocated by many experts, but whether doing so would affect the capacity to differentiate between high and low abilities is unknown. Objective: To determine the effect of electronic resources on examination performance characteristics. Design: Randomized controlled trial. Setting: Medical certification program...
September 5, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28803237/atf3-dependent-regulation-of-egr1-in-vitro-and-in-vivo
#20
Ilona Schoen, Sabine Koitzsch
BACKGROUND/AIMS: Activating transcription factor 3 (ATF3) and early growth response protein 1 (EGR1) are reported to interact, but their use as prognostic factors in cancer is discussed controversially. METHODS: We measured ATF3 and EGR1 gene expression changes in human mini-organ cultures (MOCs) of healthy nasal epithelia, UM-SCC-22B, and FADUDD cells after acid reflux exposure. Next, ATF3 and EGR1 gene expression was analysed in tumour tissues and related to the median expression of autologous reference tissue samples...
August 12, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
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