keyword
MENU ▼
Read by QxMD icon Read
search

Dual diagnosis

keyword
https://www.readbyqxmd.com/read/29140684/janus-gold-nanoplatform-for-synergetic-chemoradiotherapy-and-computed-tomography-imaging-of-hepatocellular-carcinoma
#1
Zheng Wang, Dan Shao, Zhimin Chang, Mengmeng Lu, Yingshuai Wang, Juan Yue, Dian Yang, Mingqiang Li, Qiaobing Xu, Wenfei Dong
There is a pressing need to develop nanoplatforms that integrate multimodal therapeutics to improve treatment responses and prolong the survival of patients with unresectable hepatocellular carcinoma (HCC). Mesoporous silica-coated gold nanomaterials have emerged as a novel multifunctional platform combining tunable surface plasmon resonance and mesoporous properties that exhibit multimodality properties in cancer theranostics. However, their reduced radiation-absorption efficiency and limited surface area hinder their further radiochemotherapeutic applications...
November 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29138051/sarcopenia-in-peripheral-arterial-disease-prevalence-and-impact-on-functional-status
#2
Odessa Addison, Steven J Prior, Rishi Kundi, Monica C Serra, Leslie I Katzel, Andrew W Gardner, Alice S Ryan
OBJECTIVES: To determine the prevalence of sarcopenia in older men with peripheral arterial disease (PAD) and to compare to a subset of the group to age, race, sex, and body mass index (BMI)-matched non-PAD control counterparts. We also sought to compare the functional status of those with PAD with and without sarcopenia. DESIGN: Cohort study. SETTING: A Veterans Affairs medical center. PARTICIPANTS: Sedentary, community dwelling men age 50+ years with a confirmed diagnosis of PAD (N=108; 44% black; BMI 27...
November 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29136911/one-step-detection-for-two-serological-biomarker-species-to-improve-the-diagnostic-accuracy-of-hepatocellular-carcinoma
#3
Tao Gao, Jun Zhi, Chaoli Mu, Shiyu Gu, Jing Xiao, Jie Yang, Zhaoxia Wang, Yang Xiang
At present, the accuracy of clinical hepatocellular carcinoma (HCC) diagnosis needs to be further improved. In this work, two kinds of serological biomarker species, microRNA and protein biomarker, have been detected simultaneously to identify HCC. Herein, a dual-aptamer hairpin DNA oligonucleotide is designed as the electrochemical sensing probe (ESP) to achieve this goal. The hairpin-structured DNA probe consists microRNA-16 (miR-16) complementary sequence and alpha fetoprotein (AFP) aptamer sequence, so it can both capture miR-16 and AFP...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136161/trends-and-predictors-of-syphilis-prevalence-in-the-general-population-global-pooled-analyses-of-1103-prevalence-measures-including-136-million-syphilis-tests
#4
Alex Smolak, Jane Rowley, Nico Nagelkerke, Nicholas J Kassebaum, R Matthew Chico, Eline L Korenromp, Laith J Abu-Raddad
Background: This study assessed levels, trends, and associations of observed syphilis prevalence in the general adult population using global pooled analyses. Methods: A standardized database of syphilis prevalence was compiled by pooling systematically-gathered data. Random-effects meta-analyses and meta-regressions were conducted using data from 1990-2016 to estimate pooled measures and assess predictors and trends. Countries were classified by World Health Organization regions...
November 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29130995/lncrna-uca1-promotes-mitochondrial-function-of-bladder-cancer-via-the-mir-195-arl2-signaling-pathway
#5
Hui-Jin Li, Xiao-Min Sun, Zheng-Kun Li, Qian-Wen Yin, Huan Pang, Jing-Jing Pan, Xu Li, Wei Chen
BACKGROUND/AIMS: This study aims to identify whether Urothelial Cancer Associated 1 (UCA1) regulates mitochondrial metabolic reprogramming in bladder cancer, and to explore how UCA1 participates in mitochondrial metabolism by the UCA1/miR-195/ARL2 signaling pathway; these findings may be aid in the development of tumor diagnostic and therapeutic strategies. METHODS: Bladder tissues were obtained from patients. Stable cell lines were constructed, with ectopic expression of UCA1 in UMUC2 cells and knockdown of UCA1 in 5637 cells...
November 1, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29127882/anxiety-sensitivity-and-sleep-disturbance-investigating-associations-among-patients-with-co-occurring-anxiety-and-substance-use-disorders
#6
Laura J Dixon, Aaron A Lee, Kim L Gratz, Matthew T Tull
Sleep disturbance is a common problem among individuals with anxiety and substance use disorders (SUD). Anxiety sensitivity (AS) is elevated in patients with anxiety disorders and SUD and has been linked to sleep-related problems, including insomnia and somnolence (i.e., daytime sleepiness). We examined the unique roles of AS cognitive, physical, and social concerns in sleep disturbance among a sample of 99 residential SUD patients with anxiety disorders. Clinical levels of insomnia or somnolence were evidenced by 53...
November 7, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29124812/dartintinnus-alderae-n-g-n-sp-a-brackish-water-tintinnid-ciliophora-spirotrichea-with-dual-ended-lorica-collapsibility
#7
Susan A Smith, Wen Song, Nelly A Gavrilova, Alexander V Kurilov, Weiwei Liu, George B McManus, Luciana F Santoferrara
A tintinnid ciliate isolated from waters of the Thames River (Connecticut, USA) is described through combined in vivo observation, protargol impregnation, and phylogenetic analysis. The novel genus Dartintinnus and its type species, D. alderae are distinct from established tintinnid taxa by a lorica that collapses on both anterior and posterior ends. Dartintinnus is placed in the family Eutintinnidae based on a hyaline, elongated lorica opened at both ends, a ciliary pattern including a ventral kinety, at least one dorsal kinety, and right, left and lateral fields, and a sister relationship to Eutintinnus in gene trees...
November 10, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/29119644/suicide-amongst-people-with-intellectual-disability-an-australian-online-study-of-disability-support-staff-experiences-and-perceptions
#8
S Wark, K McKay, P Ryan, A Müller
BACKGROUND: Individuals with intellectual disability (ID) have a higher likelihood of exposure to identified risk factors for suicide when compared with the general community and have been recognised as being both capable of forming intent for suicide and acting on this intent. However, in spite of research outlining these concerns from the 1970s, there remains a dearth of studies that examine suicide amongst the population of people with ID. METHOD: An online cross-sectional survey was purposively developed, with questions aimed at identifying both the experiences and current practices of support staff who assist people with ID in relation to suicide, suicidal behaviour and suicide assessment...
November 8, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29119457/dual-energy-computed-tomography-for-the-head
#9
REVIEW
Norihito Naruto, Toshihide Itoh, Kyo Noguchi
Dual energy CT (DECT) is a promising technology that provides better diagnostic accuracy in several brain diseases. DECT can generate various types of CT images from a single acquisition data set at high kV and low kV based on material decomposition algorithms. The two-material decomposition algorithm can separate bone/calcification from iodine accurately. The three-material decomposition algorithm can generate a virtual non-contrast image, which helps to identify conditions such as brain hemorrhage. A virtual monochromatic image has the potential to eliminate metal artifacts by reducing beam-hardening effects...
November 9, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29117705/personality-inventory-for-dsm-5-short-form-pid-5-sf-reliability-factorial-structure-and-relationship-with-functional-impairment-in-dual-diagnosis-patients
#10
Carmen Díaz-Batanero, Juan Ramírez-López, Sara Domínguez-Salas, Fermín Fernández-Calderón, Óscar M Lozano
Section III of the Diagnostic and Statistical Manual of Mental Disorders-Fifth edition ( DSM-5) has generated a personality paradigm consisting of 25 personality facets identified in five domains. The developed assessment instrument Personality Inventory for DSM-5 (PID-5) has showed good psychometric properties, but the potential for certain improvements still remain. In this article, a sample of 282 dual diagnosis patients is used to provide evidence of the psychometric properties of the PID-5-Short Form. The mean value of Cronbach's alpha coefficients reached ...
November 1, 2017: Assessment
https://www.readbyqxmd.com/read/29116748/mno2-functionalized-co-p-nanocomposite-a-new-theranostic-agent-for-ph-triggered-t1-t2-dual-modality-magnetic-resonance-imaging-guided-chemo-photothermal-synergistic-therapy
#11
Longhai Jin, Jianhua Liu, Ying Tang, Lanqing Cao, Tianqi Zhang, Qinghai Yuan, Yinghui Wang, Hongjie Zhang
Construction of stimuli-responsive theranostic nanoagents that can improve the sensitivity of diagnostic imaging and boost the therapeutic efficiency has been demostrated to a promising approach for cancer diagnosis and treatment. Herein, we constructed a novel theranostic agent with Co-P nanocomposites as core, mesoporous silica as shell, and MnO2 nanosheets as "gatekeeper", which have been employed for pH-activatable T1/T2 dual mode MRI-guided chemo-photothermal combination anticancer therapy in vitro and in vivo...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29115564/mir-486-functions-as-a-tumor-suppressor-in-esophageal-cancer-by-targeting-cdk4-bcas2
#12
Baoping Lang, Song Zhao
Esophageal cancer is a common tumor for which morbidity and mortality are high worldwide. We aimed to study alterations in miR-486 expression in esophageal cancers, and the effect miR-486 on esophageal cancer cell function and behavior. We collected esophageal cancer tissues/corresponding normal tissues from 20 patients and utilized three esophageal cancer cell lines and normal esophageal epithelial cells, and the expression of miR-486, CDK4 and BCAS2 was detected by qRT-PCR. Western blotting was used to detect the expression of CDK4 and BCAS2 protein...
November 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29115428/inhibition-of-p21-activated-kinase-enhances-tumour-immune-response-and-sensitizes-pancreatic-cancer-to-gemcitabine
#13
Kai Wang, Nhi Huynh, Xiao Wang, Graham Baldwin, Mehrdad Nikfarjam, Hong He
Pancreatic ductal adenocarcinoma (PDA) is one of the major types of cancer that exhibit high mortality worldwide because of the late diagnosis and the lack of effective treatment. Immunotherapy appears to be ineffective in PDA treatment due to the existence of a unique immune-suppressive microenvironment in PDA. Gemcitabine-based therapy is still the most commonly used chemotherapy to treat PDA patients with only marginal increased survival rates. This prompted us to continue the search for more effective therapy for PDA treatment...
November 7, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29113204/application-of-dual-source-ct-perfusion-imaging-and-mri-for-the-diagnosis-of-primary-liver-cancer
#14
Dongwen Zhang, Aixia Xu
The objective of the present study was to evaluate the application of dual-source CT perfusion imaging and MRI for the diagnosis of primary liver cancer. Sixty-three patients with primary liver cancer were selected between February 2015 and May 2016. All patients underwent examinations by dual-source CT perfusion imaging and MRI. The perfusion parameters of the focus center and normal liver parenchyma by CT examination and the hemodynamic parameters of the focus center and normal liver parenchyma by MRI examination were analyzed...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29113174/quantitative-analysis-of-permeability-for-glioma-grading-using-dynamic-contrast-enhanced-magnetic-resonance-imaging
#15
Ming Zhao, Li-Li Guo, Ning Huang, Qiong Wu, Li Zhou, Hui Zhao, Jing Zhang, Kuang Fu
The objective of the present study was to quantitatively analyze the permeability of tumor entity and peritumor edema in glioma grading, using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). In the present retrospective study, 80 patients underwent T1-weighted DCE-MRI examination at 3.0 T and the pathological results (including astrocytoma and oligodendroglioma) were obtained between January 2012 and June 2015. All cases were surgically validated as grade I-IV gliomas. The original DCE-MRI data were analyzed using dual compartment modified Tofts model...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29112600/low-bone-mineral-density-in-middle-aged-women-a-red-flag-for-sarcopenia
#16
Italo Campodónico, Juan E Blümel, Eugenio Arteaga, María S Vallejo, María I Valdivia
OBJECTIVE: This study evaluated whether low bone density, a condition related to aging, is associated with low muscle mass, a surrogate for sarcopenia, and whether it could be used as a marker of the condition. METHODS: We studied 483 women aged 35 to 69 years old who appeared healthy and attended a preventive gynecological examination. Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) and regional body composition. BMD was assessed using the T-score...
November 6, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29112224/variants-in-cib2-cause-dfnb48-and-not-ush1j
#17
K T Booth, K Kahrizi, M Babanejad, H Daghagh, G Bademci, S Arzhangi, D Zareabdollahi, D Duman, A El-Amraoui, M Tekin, H Najmabadi, H Azaiez, R J Smith
The genetic, mutational and phenotypic spectrum of deafness-causing genes shows great diversity and pleiotropy. The best examples are the group of genes, which when mutated can either cause non-syndromic hearing loss (NSHL) or the most common dual sensory impairment, Usher Syndrome (USH). Variants in the CIB2 gene have been previously reported to cause of hearing loss at the DFNB48 locus and deaf-blindness at the USH1J locus. In this study, we characterize the phenotypic spectrum in a multiethnic cohort with autosomal recessive non-syndromic hearing loss (ARNSHL) due to variants in the CIB2 gene...
November 7, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/29111701/mitochondrial-imaging-with-combined-fluorescence-and-stimulated-raman-scattering-microscopy-using-a-probe-of-the-aggregation-induced-emission-characteristic
#18
Xuesong Li, Meijuan Jiang, Jacky W Y Lam, Ben Zhong Tang, Jianan Y Qu
In vivo quantitative measurement of biodistribution plays a critical role in the drug/probe development and diagnosis/treatment process monitoring. In this work, we report a probe, named AIE-SRS-Mito, for imaging mitochondria in live cells via fluorescence (FL) and stimulated Raman scattering (SRS) imaging. The probe features an aggregation-induced emission (AIE) characteristic and possesses an enhanced alkyne Raman peak at 2223 cm(-1). The dual-mode imaging of AIE-SRS-Mito for selective mitochondrion-targeting was examined on a homemade FL-SRS microscope system...
November 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29111198/cumulative-effective-dose-and-cancer-risk-of-pediatric-population-in-repetitive-whole-body-scan-using-dual-energy-x-ray-absorptiometry
#19
Martin Law, Wang-Kei Ma, Eva Chan, Candy Mui, Vivian Ma, Wai-Yin Ho, Lawrance Yip, Wendy Lam
This study aims to quantitatively evaluate the cumulative effective dose and associated cancer risk of pediatric patients of US and Hong Kong population undergoing repetitive whole-body scans with dual-energy X-ray absorptiometry (DXA) during their diagnosis and follow-up periods. Organ-absorbed doses of pediatric patients undergoing DXA whole-body scan have been computer simulated using patient imaging parameters input to the Monte Carlo software PCXMC. Gender- and age-specific effective doses have been calculated with the simulated organ-absorbed doses using the ICRP-103 approach...
September 29, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29108028/decreased-plasma-concentrations-of-bdnf-and-igf-1-in-abstinent-patients-with-alcohol-use-disorders
#20
Nuria García-Marchena, Daniel Silva-Peña, Ana Isabel Martín-Velasco, María Ángeles Villanúa, Pedro Araos, María Pedraz, Rosa Maza-Quiroga, Pablo Romero-Sanchiz, Gabriel Rubio, Estela Castilla-Ortega, Juan Suárez, Fernando Rodríguez de Fonseca, Antonia Serrano, Francisco Javier Pavón
The identification of growth factors as potential biomarkers in alcohol addiction may help to understand underlying mechanisms associated with the pathogenesis of alcohol use disorders (AUDs). Previous studies have linked growth factors to neural plasticity in neurocognitive impairment and mental disorders. In order to further clarify the impact of chronic alcohol consumption on circulating growth factors, a cross-sectional study was performed in abstinent AUD patients (alcohol group, N = 91) and healthy control subjects (control group, N = 55) to examine plasma concentrations of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and IGF-1 binding protein-3 (IGFBP-3)...
2017: PloS One
keyword
keyword
2997
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"