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Dual diagnosis

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https://www.readbyqxmd.com/read/28328530/imaging-methods-for-bone-mass-evaluation-during-childhood-and-adolescence-an-update
#1
Isabela Leite Pezzuti, Adriana Maria Kakehasi, Maria Tereza Filgueiras, Juliana Albano de Guimarães, Isabela Alves Campos de Lacerda, Ivani Novato Silva
The objective of the work was to prepare an update on imaging methods for bone evaluation during childhood and adolescence. The text was based on original and review articles on imaging methods for clinical evaluation of bone mass in children and adolescents up to 20 years old. They were selected from BIREME and PUBMED by means of the following keywords: bone density; osteoporosis/diagnosis; densitometry; tomography; ultrasonography; magnetic resonance imaging; and radiogrammetry and published in Portuguese or English, in the last 10 years (2006-2016)...
March 22, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28328200/fluorescence-resonance-energy-transfer-based-dna-tetrahedron-nano-tweezer-for-highly-reliable-detection-of-tumor-related-mrna-in-living-cells
#2
Lei He, Dan-Qing Lu, Hao Liang, Sitao Xie, Can Luo, Miaomiao Hu, Liujun Xu, Xiaobing Zhang, Weihong Tan
Accurate detection and imaging of tumor-related mRNA in living cells hold great promise for early cancer detection. However, currently, most probes designed to image intracellular mRNA confront intrinsic interferences arising from complex biological matrices and resulting in inevitable false-positive signals. To circumvent this problem, a new class of intracellular DNA nanoprobe, termed DNA tetrahedron nano-tweezer (DTNT), was developed to reliably image tumor-related mRNA in living cells based on the FRET (fluorescence resonance energy transfer) "off" to "on" signal readout mode...
March 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28327886/impact-on-the-psychotic-vulnerability-of-the-therapeutic-approachin-the-prison-psychiatric-hospital-in-seville-spain
#3
P Massé-García, F J Lamas-Bosque, A Massé-Palomo
OBJECTIVES: to analyze changes in psychotic vulnerability following the implementation of a program of prison psychiatric treatment, recidivism after the release and various descriptive variables of criminological interest. MATERIALS AND METHODS: review of a sample consisting of 50 patients diagnosed with schizophrenia admitted to the Prison Psychiatric Hospital of Seville. RESULTS: there was a statistically significant reduction of psychotic vulnerability according to an assessment using the Frankfurt psychopathological inventory (FBF-3), after conducting a complete psychiatric, psychological, social and rehabilitation approach in the prison environment...
June 2017: Revista Española de Sanidad Penitenciaria
https://www.readbyqxmd.com/read/28327803/serodiagnosis-of-visceral-and-cutaneous-leishmaniasis-in-human-and-canine-populations-living-in-indigenous-reserves-in-the-brazilian-amazon-region
#4
Julia Teresa Ribeiro de Lima, Solange Maria Gennari, Herbert Sousa Soares, Antonio Humberto Hamad Minervino, Antonio Francisco Malheiros, Fernando Silveira Marques, Márcia Dalastra Laurenti, Rosangela Zacarias Machado, Arlei Marcili, Marcelo Bahia Labruna, Rodrigo Martins Soares
INTRODUCTION: Leishmaniasis is endemic to the Northern, Northeastern, Central-Western, and Southeastern regions of Brazil. We aimed to assess the epidemiological situation of leishmaniasis in humans and dogs in indigenous villages located in the States of Mato Grosso and Tocantins using a serological survey conducted in May 2011. METHODS: Serum samples were collected from 470 humans and 327 dogs living in villages of the Urubu Branco and Tapirapé Karajá indigenous reserves...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327716/chemo-photodynamic-combined-gene-therapy-and-dual-modal-cancer-imaging-achieved-by-ph-responsive-alginate-chitosan-multilayer-modified-magnetic-mesoporous-silica-nanocomposites
#5
Hong Yang, Yin Chen, Zhongyuan Chen, Yue Geng, Xiaoxue Xie, Xue Shen, Tingting Li, Shun Li, Chunhui Wu, Yiyao Liu
Multifunctional theranostics have offered some interesting new opportunities for cancer therapy and diagnosis in the last decade. Herein, magnetic mesoporous silica nanoparticles (M-MSNs) were designed and synthesized, then the photosensitizer chlorin e6 (Ce6) and antitumor drug doxorubicin (Dox) were adsorbed onto the M-MSNs. Biocompatible alginate/chitosan polyelectrolyte multilayers (PEM) were assembled on the M-MSNs to achieve a pH-responsive drug delivery system and adsorb P-gp shRNA for reversing the multidrug resistance...
March 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28327175/schizophrenia-and-substance-use-comorbidity-a-genome-wide-perspective
#6
Renato Polimanti, Arpana Agrawal, Joel Gelernter
Dual diagnosis with substance use disorders (SUDs) consistently contributes to the premature mortality and increased disability observed in schizophrenia. Large genome-wide association studies are providing the information needed to investigate the genetic architecture of psychiatric disorders. Here, we discuss recent genetic investigations of dual diagnosis (i.e., schizophrenia plus a SUD) and how these findings can inform public health messages.
March 21, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28326794/urothelial-tumors-and-dual-band-imaging-a-new-concept-in-confocal-laser-endomicroscopy
#7
Arnaud Marien, Aurélien Rock, Khaled El Maadarani, Catherine Francois, Pierre Gosset, Brigitte Mauroy, Jean-Louis Bonnal
OBJECTIVES: Confocal laser endomicroscopy (CLE) uses a low-energy laser light source to obtain microscopic histology images of bladder tissue exposed to a fluorescent dye. To evaluate the feasibility of using CLE with two fluorophores: fluorescein (FLUO) and hexylaminolevulinate (HAL) to determine histologic and cytologic bladder cancer criteria. METHODS: Patients eligible for HAL-photodynamic diagnosis-assisted transurethral resection of bladder tumor were included...
March 22, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28323295/augd-integrated-nanoprobes-for-optical-mri-ct-triple-modal-in-vivo-tumor-imaging
#8
Chao Xu, Yaling Wang, Chunyu Zhang, Yanwei Jia, Yunjing Luo, Xueyun Gao
Multi-modal imaging agents are desirable for tumor diagnosis because they can provide more information on the tumor than single-modal imaging agents. However, most reported multi-modal imaging agents are dual-modal agents rather than tri-modal agents; therefore, detailed information on the tumor may still be insufficient when such imaging agents are used. To ameliorate this issue, we synthesized a tri-modal imaging agent, composed of gold cluster and gadolinium oxide integrated nanoparticles (denoted as AuGds) using bovine serum albumin (BSA) as the template via a bio-mineralization method...
March 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28321330/ct-venography-after-knee-replacement-surgery-comparison-of-dual-energy-ct-based-monochromatic-imaging-and-single-energy-metal-artifact-reduction-techniques-on-a-320-row-ct-scanner
#9
Masafumi Kidoh, Daisuke Utsunomiya, Seitaro Oda, Takeshi Nakaura, Yoshinori Funama, Hideaki Yuki, Kenichiro Hirata, Masahiro Hatemura, Tomohiro Namimoto, Yasuyuki Yamashita
BACKGROUND: An optimal metal artifact reduction (MAR) technique is needed for a reliable and accurate image-based diagnosis. PURPOSE: Using a 320-row scanner, we compared the dual-energy computed tomography (CT)-based monochromatic and the single-energy metal artifact reduction (SEMAR) techniques for CT venography (CTV) to identify the better imaging method for diagnosing deep vein thrombosis (DVT) in patients who had undergone knee replacement surgery. MATERIAL AND METHODS: Twenty-three consecutive patients with suspected DVT after unilateral knee replacement surgery underwent dual-energy CT (135/80 kVp)...
February 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28319607/reduced-bone-mineral-density-in-children-with-screening-detected-celiac-disease
#10
Sara Björck, Charlotte Brundin, Magnus Karlsson, Daniel Agardh
OBJECTIVES: To assess if bone mass and metabolism are impaired in genetically at risk children with screening-detected celiac disease. METHODS: Included were 71 children with screening-detected celiac disease diagnosed at 10.0 ± 0.7 (mean ± SD) years and 142 matched controls as well as 30 children with screening-detected celiac disease diagnosed at 3.3 ± 0.4 years of age presently on a gluten-free diet for 6.9 ± 1.1 years and 60 matched controls...
March 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28317976/albumin-based-nanoparticles-loaded-with-hydrophobic-gadolinium-chelates-as-t1-t2-dual-mode-contrast-agents-for-accurate-liver-tumor-imaging
#11
Lirong Wang, Hongyu Lin, Lingceng Ma, Jianbin Jin, Taipeng Shen, Ruixue Wei, Xiaomin Wang, Hua Ai, Zhong Chen, Jinhao Gao
Magnetic resonance contrast agents with T1-T2 dual mode contrast capability have attracted considerable interest because they offer complementary and synergistic diagnostic information, leading to high imaging sensitivity and accurate diagnosis. Here, we reported a facile strategy to construct albumin based nanoparticles loaded with hydrophobic gadolinium chelates by hydrophobic interaction for magnetic resonance imaging (MRI). We synthesized a glycyrrhetinic acid-containing Gd-DOTA derivative (GGD) and loaded GGD molecules into BSA nanoparticles to form GGD-BSA nanoparticles (GGD-BSA NPs)...
March 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28315913/does-dual-time-point-18-f-fdg-pet-ct-scan-add-in-the-diagnosis-of-hepatocellular-carcinoma
#12
Bing Wu, Yanzhao Zhao, Yiqiu Zhang, Hui Tan, Hongcheng Shi
OBJECTIVE: The aim of this study was to evaluate the usefulness of dual-time-point (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) with semiquantitative analyses for patients with hepatocellular carcinoma (HCC). SUBJECTS AND METHODS: The 150 patients with clinically suspected liver malignancies underwent dual-time-point (18)F-FDG PET/CT imaging. The maximum standardized uptake value (SUVmax) was calculated at both time points of PET imaging...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28315744/cardiac-implantable-electronic-device-infections-who-is-at-greatest-risk
#13
Parijat Saurav Joy, Gagan Kumar, Jeanne E Poole, Barry London, Brian Olshansky
BACKGROUND: Cardiac Implantable Electronic Device (CIED) infections are associated with hospitalization, mortality, increased costs and adverse outcomes. OBJECTIVE: Determine the burden of infections for CIEDs based on device type, associated comorbidities and clinical characteristics over a 12-year period. METHODS: Utilizing the National Inpatient Sample database from 2000-2012, procedures for device related infection (DRI) were identified using ICD-9-CM code for CIED removal with diagnosis codes for device-related infection or systemic infection...
March 15, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28314546/liaison-psychiatry-professionals-views-of-general-hospital-care-for-patients-with-mental-illness-the-care-of-patients-with-mental-illness-in-the-general-hospital-setting
#14
J Noblett, A Caffrey, T Deb, A Khan, E Lagunes-Cordoba, O Gale-Grant, C Henderson
OBJECTIVE: Explore the experiences of liaison psychiatry professionals, to gain a greater understanding of the quality of care patients with mental illness receive in the general hospital setting; the factors that affect the quality of care; and their insights on interventions that could improve care. METHODS: A survey questionnaire and qualitative in depth interviews were used to collect data. Data collection took place at the Royal College of Psychiatrists Faculty of Liaison Psychiatry Annual conference...
April 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28299004/contribution-of-dual-fluorescein-and-indocyanine-green-angiography-to-the-appraisal-of-presumed-tuberculous-chorioretinitis-in-a-non-endemic-area
#15
Raphael Massy, Carl P Herbort
PURPOSE: To assess the respective involvement of retina versus choroid in presumed ocular tuberculosis (POT) in a non-endemic area using dual fluorescein (FA) and indocyanine green angiography (ICGA). METHODS: We retrospectively analyzed cases diagnosed with POT at the Centre for Ophthalmic Specialized Care, Lausanne, Switzerland. Angiography signs were quantified using an established dual FA and ICGA scoring system for uveitis. RESULTS: Out of 1739 uveitis patients visited from 1995 to 2014, 53 (3%) were diagnosed with POT; of whom 28 patients (54 eyes) had sufficient data available to be included in this study...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28298387/diagnosis-of-chronic-thromboembolic-pulmonary-hypertension
#16
REVIEW
Deepa Gopalan, Marion Delcroix, Matthias Held
Chronic thromboembolic pulmonary hypertension (CTEPH) is the only potentially curable form of pulmonary hypertension. Rapid and accurate diagnosis is pivotal for successful treatment. Clinical signs and symptoms can be nonspecific and risk factors such as history of venous thromboembolism may not always be present. Echocardiography is the recommended first diagnostic step. Cardiopulmonary exercise testing is a complementary tool that can help to identify patients with milder abnormalities and chronic thromboembolic disease, triggering the need for further investigation...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28294356/prevalence-and-clinical-significance-of-left-bundle-branch-block-according-to-classical-or-strict-definition-criteria-in-permanent-pacemaker-patients
#17
Andrea Mazza, Maria Grazia Bendini, Raffaele De Cristofaro, Mariolina Lovecchio, Sergio Valsecchi, Massimo Leggio, Giuseppe Boriani
BACKGROUND: Previous studies have shown that the presence of left bundle branch block (LBBB) is associated with an increased risk of cardiac mortality and heart failure (HF). Recently, new criteria to define strict LBBB have been proposed: QRS duration ≥140 ms for men and ≥130 ms for women, along with mid-QRS notching or slurring in ≥2 contiguous leads. HYPOTHESIS: We assessed the prevalence and prognostic significance of LBBB according to classical (QRS duration ≥120ms) and strict criteria in permanent pacemaker patients...
March 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28293856/imaging-of-diabetic-bone
#18
Federico Ponti, Sara Guerri, Claudia Sassi, Giuseppe Battista, Giuseppe Guglielmi, Alberto Bazzocchi
Diabetes is an important concern in terms of medical and socioeconomic costs; a high risk for low-trauma fractures has been reported in patients with both type 1 and type 2 diabetes. The mechanism involved in the increased fracture risk from diabetes is highly complex and still not entirely understood; obesity could play an important role: recent evidence suggests that the influence of fat on bone is mainly dependent on the pattern of regional fat deposition and that an increased amount of visceral adipose tissue negatively affects skeletal health...
March 14, 2017: Endocrine
https://www.readbyqxmd.com/read/28292364/comparative-analysis-of-fluorescence-in-situ-hybridization-and-real-time-polymerase-chain-reaction-in-diagnosis-of-chronic-myeloid-leukemia
#19
Javaid Ali, Saleem Ahmed Khan, Shan -E- Rauf, Muhammad Ayyub, Nadir Ali, Nabeel Khan Afridi
OBJECTIVE: To compare the sensitivity and specificity of fluorescence in situ hybridization (FISH) with real time polymerase chain reaction (RT-PCR) in the diagnosis of Chronic Myeloid Leukemia (CML). STUDY DESIGN: A cross-sectional, analytical study. PLACE AND DURATION OF STUDY: Haematology Department, Armed Forces Institute of Pathology, Rawalpindi, from January 2012 to February 2014. METHODOLOGY: A total number of 87 patients of CML were studied...
January 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28291277/diagnostiska-fel-och-misstag-%C3%A3-r-vanliga-och-sv%C3%A3-ra-att-m%C3%A3-ta
#20
Anders von Heijne
Diagnostic errors are prevalent and hard to measure Diagnostic errors are prevalent in all aspects of healthcare and a common cause of adverse events. They are often the result of multifactorial events, where there is a complex interplay between cognitive factors, system factors and lack of adequate knowledge. The generic, iterative diagnostic process, with abductive, deductive and inductive components supported by tests and the physical exam, leads to a correct diagnosis for the great majority of patients, but can be derailed by suboptimal thinking, lack of adequate information and external factors such as stress and work overload...
March 13, 2017: Läkartidningen
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