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https://www.readbyqxmd.com/read/28944911/microrna%C3%A2-3666-inhibits-breast-cancer-cell-proliferation-by-targeting-sirtuin-7
#1
Di Li, Lifei Li
The abnormal expression of microRNAs (miRNAs) is associated with cancer initiation and progression. miRNAs functioning as oncogenes or tumor suppressors represent novel biomarkers for cancer diagnosis, prognosis, and serve as therapeutic tools. MiR‑3666 has been reported as a tumor suppressor in various types of cancer; however, its role in breast cancer remains unknown. In the current study, the aim was to investigate the potential role of miR‑3666 in breast cancer. It was identified that miR‑3666 was decreased in breast cancer cell lines and that the overexpression of miR‑3666 inhibited breast cancer cell proliferation...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28942795/genetics-of-mitochondrial-disease
#2
Russell P Saneto
Mitochondria are intracellular organelles responsible for adenosine triphosphate production. The strict control of intracellular energy needs require proper mitochondrial functioning. The mitochondria are under dual controls of mitochondrial DNA (mtDNA) and nuclear DNA (nDNA). Mitochondrial dysfunction can arise from changes in either mtDNA or nDNA genes regulating function. There are an estimated ∼1500 proteins in the mitoproteome, whereas the mtDNA genome has 37 proteins. There are, to date, ∼275 genes shown to give rise to disease...
2017: Advances in Genetics
https://www.readbyqxmd.com/read/28939490/uptake-and-bioreactivity-of-charged-chitosan-coated-superparamagnetic-nanoparticles-as-promising-contrast-agents-for-magnetic-resonance-imaging
#3
Gabriela Kania, Magdalena Sternak, Agnieszka Jasztal, Stefan Chlopicki, Agnieszka Błażejczyk, Anna Nasulewicz-Goldeman, Joanna Wietrzyk, Krzysztof Jasiński, Tomasz Skórka, Szczepan Zapotoczny, Maria Nowakowska
Bioreactivity of superparamagnetic iron oxide nanoparticles (SPION) coated with thin layers of either cationic or anionic chitosan derivatives and serving as contrast agents in magnetic resonance imaging (MRI) was studied in vivo using BALB/c mouse model. Synthesized dual-modal fluorescing SPION were tracked in time using both fluorescent imaging and MRI. Although SPION started to be excreted by kidneys relatively shortly after administration they were uptaken by liver enhancing MRI contrast even up to 7 days...
September 19, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28937683/a-vitronectin-derived-peptide-reverses-ovariectomy-induced-bone-loss-via-regulation-of-osteoblast-and-osteoclast-differentiation
#4
Seung-Ki Min, Hyun Ki Kang, Sung Youn Jung, Da Hyun Jang, Byung-Moo Min
Osteoporosis affects millions of people worldwide by promoting bone resorption and impairing bone formation. Bisphosphonates, commonly used agents to treat osteoporosis, cannot reverse the substantial bone loss that has already occurred by the time of diagnosis. Moreover, their undesirable side-effects, including osteonecrosis of the jaw, have been reported. Here, we demonstrated that a new bioactive core vitronectin-derived peptide (VnP-16) promoted bone formation by accelerating osteoblast differentiation and activity through direct interaction with β1 integrin followed by FAK activation...
September 22, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28935032/effect-of-definition-on-incidence-and-prognosis-of-type-2-myocardial-infarction
#5
Thomas Nestelberger, Jasper Boeddinghaus, Patrick Badertscher, Raphael Twerenbold, Karin Wildi, Dominik Breitenbücher, Zaid Sabti, Christian Puelacher, Maria Rubini Giménez, Nikola Kozhuharov, Ivo Strebel, Lorraine Sazgary, Deborah Schneider, Janina Jann, Jeanne du Fay de Lavallaz, Òscar Miró, F Javier Martin-Sanchez, Beata Morawiec, Damian Kawecki, Piotr Muzyk, Dagmar I Keller, Nicolas Geigy, Stefan Osswald, Tobias Reichlin, Christian Mueller
BACKGROUND: Uncertainties regarding the most appropriate definition and treatment of type 2 myocardial infarction (T2MI) due to supply-demand mismatch have contributed to inconsistent adoption in clinical practice. OBJECTIVES: This study sought a better understanding of the effect of the definition of T2MI on its incidence, treatment, and event-related mortality, thereby addressing an important unmet clinical need. METHODS: The final diagnosis was adjudicated in patients presenting with symptoms suggestive of myocardial infarction by 2 independent cardiologists by 2 methods: 1 method required the presence of coronary artery disease, a common interpretation of the 2007 universal definition (T2MI2007); and 1 method did not require coronary artery disease, the 2012 universal definition (T2MI2012)...
September 26, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28932084/characterizing-gastrointestinal-stromal-tumors-and-evaluating-neoadjuvant-imatinib-by-sequencing-of-endoscopic-ultrasound-biopsies
#6
Per Hedenström, Bengt Nilsson, Akif Demir, Carola Andersson, Fredrik Enlund, Ola Nilsson, Riadh Sadik
AIM: To evaluate endoscopic ultrasound (EUS)-guided biopsies for the pretreatment characterization of gastrointestinal stromal tumors (GIST) to personalize the management of patients. METHODS: All patients with lesions suspected to be GIST who were referred for EUS-sampling at a tertiary Swedish center were eligible for inclusion 2006-2015. During the observational study phase (2006-2011), routine fine-needle-aspiration (EUS-FNA) was performed. In 2012-2015, we converted to an interventional, randomized protocol with dual sampling EUS-FNA and fine-needle-biopsy-sampling (EUS-FNB) for all lesions...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28929810/dynamic-contrast-enhanced-perfusion-area-detector-ct-preliminary-comparison-of-diagnostic-performance-for-n-stage-assessment-with-fdg-pet-ct-in-non-small-cell-lung-cancer
#7
Yoshiharu Ohno, Yasuko Fujisawa, Naoki Sugihara, Yuji Kishida, Shinichiro Seki, Hisanobu Koyama, Takeshi Yoshikawa
OBJECTIVE: The objective of our study was to directly compare the capability of dynamic first-pass contrast-enhanced (CE) perfusion area-detector CT (ADCT) and FDG PET/CT for differentiation of metastatic from nonmetastatic lymph nodes and assessment of N stage in patients with non-small cell lung carcinoma (NSCLC). SUBJECTS AND METHODS: Seventy-seven consecutive patients, 45 men (mean age ± SD, 70.4 ± 5.9 years) and 32 women (71.2 ± 7.7 years), underwent dynamic first-pass CE-perfusion ADCT at two or three different positions for covering the entire thorax, FDG PET/CT, surgical treatment, and pathologic examination...
September 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28927860/the-utility-of-dual-energy-computed-tomography-in-the-diagnosis-of-pulmonary-thromboembolism-caused-by-post-vertebroplasty-cement-a-case-report
#8
Carlos Pérez-Serrano, Ivan Vollmer, Rosario J Perea
No abstract text is available yet for this article.
September 15, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28927212/fluorescein-guided-neuroendoscopy-for-intraventricular-lesions-a-case-series
#9
Alessandro Fiorindi, Alessandro Boaro, Giulia Del Moro, Pierluigi Longatti
BACKGROUND: The benefits of neuroendoscopy in the pathological diagnosis of intra- and paraventricular tumors have already been shown in many neurosurgical studies. However, most authors agree that neuroendoscopic biopsies are not infrequently inconclusive due to small or inadequate samples, prompting the need for new diagnostic strategies. OBJECTIVE: To describe a technique not previously reported in the literature, combining neuroendoscopy with angiofluorescein guidance for the pathological diagnosis of intra- and paraventricular tumors...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28926125/the-prevalence-of-vertebral-fractures-is-associated-with-reduced-hip-bone-density-and-inferior-peripheral-appendicular-volumetric-bone-density-and-structure-in-older-women
#10
Lisa Johansson, Daniel Sundh, Michael Zoulakis, Robert Rudäng, Anna Darelid, Helena Brisby, Anna G Nilsson, Dan Mellström, Mattias Lorentzon
Vertebral fractures (VF) are among the most severe and prevalent osteoporotic fractures. Their association with bone microstructure have been investigated in several retrospective case-control studies with spine radiography for diagnosis of VF. The aim of this population-based cross-sectional study of 1027 women aged 75-80 years, was to investigate if prevalent VF, identified by vertebral fracture assessment (VFA) by dual-energy X-ray absorptiometry (DXA), was associated with appendicular volumetric bone density, structure and bone material strength index (BMSi), independently of hip areal bone mineral density (aBMD)...
September 19, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28923411/hormone-replacement-therapy-after-treatment-for-cervical-cancer-are-we-adhering-to-standard-of-care
#11
Lisa A Rauh, Aaron F Pannone, Leigh A Cantrell
OBJECTIVE: The aim of this study was to assess hormone replacement therapy (HRT) and bone care health maintenance practices for cervical cancer patients with iatrogenic menopause, and, secondarily, to investigate the potential impact of specific demographic and clinical factors. METHODS: Women diagnosed with iatrogenic menopause due to cervical cancer treatment between January 1, 2005 and December 31, 2015 were identified from the University of Virginia's tumor registry...
September 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28918335/modern-diagnosis-of-chronic-thromboembolic-pulmonary-hypertension
#12
Aileen Kharat, Anne-Lise Hachulla, Stéphane Noble, Frédéric Lador
Chronic thromboembolic pulmonary hypertension (CTEPH) should be suspected in patients presenting persistent dyspnea three months after a pulmonary embolism or in patients presenting with acute pulmonary embolism and suggestive images on the CT-scan. For these patients, a specific diagnostic work-up should be performed. First step consists of the ventilation/perfusion (V/Q) scan which is a good screening test due to its high sensitivity and high negative predictive value. Pulmonary angiography remains the gold standard approach for the confirmation of the diagnosis and pre-surgical evaluation of CTEPH...
September 9, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28916572/anthropometric-indicators-as-body-fat-discriminators-in-children-and-adolescents-a-systematic-review-and-meta-analysis
#13
REVIEW
Carlos As Alves Junior, Michel C Mocellin, Eliane C Andrade Gonçalves, Diego As Silva, Erasmo Bsm Trindade
We analyzed the discriminatory capacity of anthropometric indicators for body fat in children and adolescents. This systematic review and meta-analysis included cross-sectional and clinical studies comprising children and adolescents aged 2-19 y that tested the discriminatory value for body fat measured by anthropometric methods or indexes generated by anthropometric variables compared with precision methods in the diagnosis of body fat [dual-energy X-ray absorptiometry (DXA), computed tomography, air displacement plethysmography (ADP), or MRI]...
September 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28904856/mir-101-inhibits-ovarian-carcinogenesis-by-repressing-the-expression-of-brain-derived-neurotrophic-factor
#14
Ying Xu, Lei Xu, Jianbin Zheng, Lei Geng, Shuping Zhao
Ovarian cancer is one of the most lethal malignant gynecological tumors as a result of difficulties in early-stage detection and a lack of effective treatments for patients with advanced or recurrent cancer. In the present study, we aimed to explore whether some of the microRNA (miRNA) content of serum might be related to ovarian cancer, as well as the role of these miRNAs and their intercellular transport via exosomes in ovarian cancer. We first detected the expression of six candidate miRNAs in ovarian cancer tissues and adjacent nontumor ovarian samples from 36 patients and confirmed the altered expression of four miRNAs...
September 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28901350/recent-developments-in-the-synthesis-properties-and-biomedical-applications-of-core-shell-superparamagnetic-iron-oxide-nanoparticles-with-gold
#15
REVIEW
Sandip Sabale, Priyanka Kandesar, Vidhya Jadhav, Rachel Komorek, Radha Kishan Motkuri, Xiao-Ying Yu
In the last decade, magnetic nanoparticles (MNPs), especially superparamagnetic iron oxide nanoparticles (SPIONs), have immensely promoted the advancement of diagnostics and theranostics in the biomedical field. The unique properties of the SPIONs-core and the functional gold (Au)-shell together (SPIONS/Au core/shell or CS) have a wide range of biomedical applications including, but not limited to, magnetic resonance imaging (MRI), dual modality MRI/computed tomography (CT), photo-induced and magnetic fluid hyperthermia (MFH), drug delivery, biosensors, and bio-separation...
September 13, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28899125/reduction-of-metal-artifacts-from-unilateral-hip-arthroplasty-on-dual-energy-ct-with-metal-artifact-reduction-software
#16
Dong Yue, Cheng Fan Rong, Cai Ning, Hu Liang, Liu Ai Lian, Wang Ru Xin, Luo Ya Hong
Background The evaluation of hip arthroplasty is a challenge in computed tomography (CT). The virtual monochromatic spectral (VMS) images with metal artifact reduction software (MARs) in spectral CT can reduce the artifacts and improve the image quality. Purpose To evaluate the effects of VMS images and MARs for metal artifact reduction in patients with unilateral hip arthroplasty. Material and Methods Thirty-five patients underwent dual-energy CT. Four sets of VMS images without MARs and four sets of VMS images with MARs were obtained...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28893616/does-antero-lateral-ankle-impingement-exist
#17
REVIEW
F Molinier, J Benoist, F Colin, J Padiolleau, S Guillo, J Stone, T Bauer
Antero-lateral ankle impingement syndrome (ALAIS) is a well-established clinical entity that is a common consequence of ankle sprains. Injury to the anterior talo-fibular ligament plays a key role in the genesis of ALAIS. Arthroscopic antero-lateral synovectomy is the standard of care. However, this treatment approach may deserve to be challenged, as it does not include any procedure on the ligaments, despite the presence in some patients of lateral rotational micro-instability of the ankle, without objective laxity...
September 8, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28892572/deconstructing-normal-pressure-hydrocephalus-ventriculomegaly-as-early-sign-of-neurodegeneration
#18
REVIEW
Alberto J Espay, Gustavo A Da Prat, Alok K Dwivedi, Federico Rodriguez-Porcel, Jennifer E Vaughan, Michela Rosso, Johnna L Devoto, Andrew P Duker, Mario Masellis, Charles D Smith, J George T Mandybur, Aristide Merola, Anthony E Lang
Idiopathic normal pressure hydrocephalus (NPH) remains both over-suspected on clinical grounds and under-confirmed when based on immediate and sustained response to cerebrospinal fluid diversion. Poor long-term post-shunt benefits and findings of neurodegenerative pathology in most patients with adequate follow up suggests that hydrocephalic disorders appearing in late adulthood may often result from initially unapparent parenchymal abnormalities. We critically review the NPH literature, highlighting the near universal lack of blinding and controls, the absence of specific clinical, imaging, or pathologic features, and the ongoing dependence for diagnostic confirmation on variable cutoffs of gait response to bedside fluid-drainage testing...
September 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28888199/chlorambucil-labelled-with-the-phenosafranin-scaffold-as-a-new-chemotherapeutic-for-imaging-and-cancer-treatment
#19
Beata Miksa, Malgorzata Sierant, Ewa Skorupska, Adam Michalski, Slawomir Kazmierski, Urszula Steinke, Artur Rozanski, Pawel Uznanski
Here we report the first of the phenosafranin-chlorambucil conjugate as a new type of a chemotherapeutic agent suitable for dual detection methods (spectrophotometric and fluorescence) in imaging systems and cancer treatment. The synthetic cationic dye (3,7-diamino-5-phenylphenazinium chloride) is used as a fluorescent light-triggered scaffold that acts as a carrier for an anti-cancer drug. The chlorambucil was attached covalently via amide bonds to the bifunctional fluorophore, which facilitates tracking with visible light...
September 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28885315/tuberous-breast-past-present-and-future-personal-classification-treatment-and-surgical-outcomes
#20
Alessandro Innocenti, Marco Innocenti, Francesco Mori, Dario Melita, Francesco Ciancio, Adriana Cordova
BACKGROUND: Tuberous breast (TB) is a rare congenital deformity, which may appear in different clinical forms representing various degrees of a single pathological entity. The worst cases are characterized by severe hypoplasia. Following a detailed analysis of the available relevant literature and a significant number of treated cases, in this article, the authors propose a new classification, with the aim of summarizing and simplifying a more intuitive categorization of the malformation, considering all the clinical aspects and including all types of TBs, even the minor ones, thus allowing a more immediate diagnosis and surgical planning...
September 6, 2017: Annals of Plastic Surgery
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