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https://www.readbyqxmd.com/read/27933211/systematic-review-and-quality-analysis-of-emerging-diagnostic-measures-for-calcium-pyrophosphate-crystal-deposition-disease
#1
Y Wu, K Chen, R Terkeltaub
OBJECTIVES: Calcium pyrophosphate crystal deposition disease (CPPD) is common, yet prevalence and overall clinical impact remain unclear. Sensitivity and specificity of CPPD reference standards (conventional crystal analysis (CCA) and radiography (CR)) were meta-analysed by EULAR (published 2011). Since then, new diagnostic modalities are emerging. Hence, we updated 2009-2016 literature findings by systematic review and evidence grading, and assessed unmet needs. METHODS: We performed systematic search of full papers (PubMed, Scopus/EMBASE, Cochrane 2009-2016 databases)...
2016: RMD Open
https://www.readbyqxmd.com/read/27932434/rapidly-progressing-dual-infection-with-aspergillus-and-rhizopus-when-soil-inhabitants-become-deadly-invaders
#2
Milind Bhagat, Alwyn Rapose
We present a case report of a 61-year-old patient with acute pulmonary and cerebral infections with Aspergillus and Rhizopus. The only risk factor for invasive fungal disease was high-dose corticosteroids used to treat her chronic obstructive pulmonary disease exacerbation. She had rapid progression and succumbed to her infections within 2 weeks of diagnosis in spite of aggressive antifungal therapy and surgery. To the best of our knowledge, this is the first reported case of rapidly fatal dual infection with Aspergillus and Rhizopus Our case highlights the role of high-dose corticosteroids as a risk factor for invasive fungal disease in patients without traditional risk factors like haematological malignancies, solid organ transplantation or uncontrolled diabetes...
December 8, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27932250/false-negative-mri-breast-screening-in-high-risk-women
#3
A J Maxwell, Y Y Lim, E Hurley, D G Evans, A Howell, S Gadde
AIM: To determine the frequency of and reasons for false-negative breast magnetic resonance imaging (MRI) examinations in high-risk women undergoing annual screening. MATERIALS AND METHODS: The family history clinic database was interrogated and women at high risk of breast cancer who had undergone screening MRI and been diagnosed with breast cancer within 2 years of the MRI examination were identified. All available MRI examinations were reviewed and classified by two radiologists...
December 5, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27931253/alcohol-use-in-opioid-agonist-treatment
#4
REVIEW
Seonaid Nolan, Jan Klimas, Evan Wood
Alcohol misuse among individuals receiving agonist treatment for an opioid use disorder is common and is associated with significant morbidity and mortality. At present, though substantial research highlights effective strategies for the screening, diagnosis and management of an alcohol or opioid use disorder individually, less is known about how best to care for those with a dual diagnosis especially since common treatments for opioid addiction may be contraindicated in a setting of alcohol use. This review summarizes existing research and characterizes the prevalence, clinical implications and management of alcohol misuse among individuals with opioid addiction...
December 8, 2016: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/27929242/community-acquired-pneumonia-in-adults-diagnosis-and-management
#5
Alexander Kaysin, Anthony J Viera
Community-acquired pneumonia is a leading cause of death. Risk factors include older age and medical comorbidities. Diagnosis is suggested by a history of cough, dyspnea, pleuritic pain, or acute functional or cognitive decline, with abnormal vital signs (e.g., fever, tachycardia) and lung examination findings. Diagnosis should be confirmed by chest radiography or ultrasonography. Validated prediction scores for pneumonia severity can guide the decision between outpatient and inpatient therapy. Using procalcitonin as a biomarker for severe infection may further assist with risk stratification...
November 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27927273/cervical-infection-of-oncogenic-human-papillomavirus-hpv-types-in-beijing-china
#6
Ying Li, Ke Huang, Pei Li Ji, Lei Song, Hong Tu Liu
OBJECTIVE: This study was designed to determine the prevalence of oncogenic human papillomavirus (HPV) in cervical infections in Beijing, China, and to investigate the odds ratio (OR) of HPV single and multiple infections in abnormal cytology. METHODS: A total of 19,018 specimens from outpatients in the department of obstetric and gynecology were collected. They were detected using high-risk HPV genotyping real-time polymerase chain reaction (PCR) kit and analyzed by ThinPrep cytology test for cervical pathological diagnosis...
October 2016: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/27924381/dual-energy-x-ray-absorptiometry-and-fracture-prediction-in-patients-with-spinal-cord-injuries-and-disorders
#7
L Abderhalden, F M Weaver, M Bethel, H Demirtas, S Burns, J Svircev, H Hoenig, K Lyles, S Miskevics, L D Carbone
: Low T-scores at the hip predict incident fractures in persons with a SCI. INTRODUCTION: Persons with a spinal cord injury (SCI) have substantial morbidity and mortality following osteoporotic fractures. The objective of this study was to determine whether dual-energy X-ray absorptiometry (DXA) measurements predict osteoporotic fractures in this population. METHODS: A retrospective historical analysis that includes patients (n = 552) with a SCI of at least 2 years duration who had a DXA performed and were in the VA Spinal Cord Disorders Registry from fiscal year (FY) 2002-2012 was performed...
December 6, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27921150/bone-mineral-density-is-decreased-in-fibromyalgia-syndrome-a-systematic-review-and-meta-analysis
#8
Sikarin Upala, Wai Chung Yong, Anawin Sanguankeo
Previous studies have shown that fibromyalgia syndrome (FMS) is associated with low level of physical activity and exercise, which may lead to an increased risk of osteoporosis. However, studies of bone mineral density (BMD) in fibromyalgia have shown conflicting results. Thus, we conducted a systematic review and meta-analysis to better characterize the association between FMS and BMD. A comprehensive search of the databases MEDLINE and EMBASE was performed from inception through May 2016. The inclusion criterion was the observational studies' assessment of the association between fibromyalgia and bone mineral density in adult subjects...
December 5, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27920894/recent-advances-in-the-preparation-and-application-of-multifunctional-iron-oxide-and-liposome-based-nanosystems-for-multimodal-diagnosis-and-therapy
#9
REVIEW
Marzia Marciello, Juan Pellico, Irene Fernandez-Barahona, Fernando Herranz, Jesus Ruiz-Cabello, Marco Filice
Nowadays, thanks to the successful discoveries in the biomedical field achieved in the last two decades, a deeper understanding about the complexity of mechanistic aspects of different pathological processes has been obtained. As a consequence, even the standard therapeutic protocols have undergone a vast redesign. In fact, the awareness about the necessity to progress towards a combined multitherapy in order to potentially increase the final healing chances has become a reality. One of the crucial elements of this novel approach is that large amounts of detailed information are highly needed and in vivo imaging techniques represent one of the most powerful tools to visualize and monitor the pathological state of the patient...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27920512/the-burden-of-chronic-obstructive-pulmonary-disease-associated-with-maintenance-monotherapy-in-the-uk
#10
Susan C Edwards, Sian E Fairbrother, Anna Scowcroft, Gavin Chiu, Andrew Ternouth, Brian J Lipworth
BACKGROUND: This study characterized a cohort of chronic obstructive pulmonary disease (COPD) patients on maintenance bronchodilator monotherapy for ≥6 months to establish their disease burden, measured by health care utilization. METHODS: Data were extracted from the UK Clinical Practice Research Datalink and linked to Hospital Episode Statistics. The monotherapy period spanned the first prescription of a long-acting β2-adrenergic agonist or a long-acting muscarinic antagonist until the end of the study (December 31, 2013) or until step up to dual/triple therapy, for example, addition of another long-acting bronchodilator, an inhaled corticosteroid, or both...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27918650/clinical-value-of-fully-automated-p16-ki-67-dual-staining-in-the-triage-of-hpv-positive-women-in-the-norwegian-cervical-cancer-screening-program
#11
Irene T Ovestad, Ingvild Dalen, Elisabeth Hansen, Janne L D Loge, Britt Mona Dybdahl, Marius B Dirdal, Pia Moltu, Jannicke M Berland
BACKGROUND: More accurate biomarkers in cervical cytology screening could reduce the number of women unnecessarily referred for biopsy. This study investigated the ability of p16/Ki-67 dual staining to predict high-grade cervical intraepithelial neoplasia (CIN) in human papillomavirus (HPV)-positive women from the Norwegian Cervical Cancer Screening Program. METHODS: Automated p16/Ki-67 dual staining was performed on liquid-based cytology samples from 266 women who were HPV-positive at their secondary screening...
December 5, 2016: Cancer
https://www.readbyqxmd.com/read/27912849/the-othering-of-old-age-insights-from-postcolonial-studies
#12
Silke van Dyk
When it comes to old age, we are witnessing almost revolutionary changes at the present time. After decades of ignorance and lack of public interest, old age has fundamentally been re-negotiated. A diverse range of authors have diagnosed the growing bifurcation of old age into a rather independent and capable Third Age and a deep old Fourth Age that is characterized by sickness, frailty and dependency. Against this backdrop, many gerontologists claim that the so-called young-old are praised and valued for their (ongoing) "sameness" in terms of midlife-norms and capabilities, whereas the oldest old are increasingly excluded from humanity by radical "othering"...
December 2016: Journal of Aging Studies
https://www.readbyqxmd.com/read/27909511/internal-jugular-vein-complete-thrombosis-after-dual-chamber-pacemaker-implant
#13
Angelo Placci, Maria Mattioli, Maria Francesca Notarangelo, Gianluca Gonzi, Marco Zardini
Venous thrombosis after pacemaker implant is a known, although often underrecognized condition that can challenge system revision or upgrading, leading occasionally to thromboembolic complications. Several factors are considered to promote thrombus formation. Among them, alteration of blood flow mechanics due to the presence of catheters in the vessel lumen may itself play a pivotal role. Hereby we present the case of a 65-year old men who underwent a dual-chamber pacemaker implant in another institute for sick sinus syndrome by means of left cephalic venous access...
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27908388/the-unknown-association-of-ppis-with-chest-pain-in-patients-with-known-treated-coronary-artery-disease-a-diagnostic-dilemma
#14
Fahad Javed, Stephen Ramee
Patients with coronary artery disease (CAD) are destined to lifelong antiplatelet therapy in form of aspirin (acetylsalicylic acid) alone, or in combination with other P2Y2 inhibitors. Proton pump inhibitors (PPIs) are the preferred agents for the treatment and prophylaxis of gastrointestinal injury associated with nonsteroidal anti-inflammatory drug or acetylsalicylic acid or both,(1) but recent data has raised questions about their association with negative cardiovascular events. We report 2 cases of patients with known CAD presented with chest pain mimicking angina pectoris that successfully resolved on discontinuation of the PPIs...
July 2016: Current Problems in Cardiology
https://www.readbyqxmd.com/read/27907049/dual-energy-ct-pulmonary-angiography-with-6g-iodine-a-propensity-score-matched-study
#15
Andreas Meier, Kai Higashigaito, Katharina Martini, Moritz Wurnig, Burkhardt Seifert, Dagmar Keller, Thomas Frauenfelder, Hatem Alkadhi
OBJECTIVE: To evaluate the performance of low contrast media (CM) dose dual-energy computed tomography pulmonary angiography (CTPA) with advanced monoenergetic reconstructions in patients with suspected pulmonary embolism (PE). MATERIALS AND METHODS: The study had institutional review board approval; all patients gave written informed consent. Forty-one patients (25 men, 16 women, mean age 62.9±14.7 years) undergoing low CM dose (15ml, 6g iodine) dual-energy CTPA with advanced monoenergetic reconstructions were matched via propensity-scoring based on logistic regression analysis with a comparison group of 41 patients (24 men, 17 women, mean age 62...
2016: PloS One
https://www.readbyqxmd.com/read/27906009/current-trends-and-intricacies-in-the-management-of-hiv-associated-pulmonary-tuberculosis
#16
REVIEW
Narendran Gopalan, Padmapriyadarsini Chandrasekaran, Soumya Swaminathan, Srikanth Tripathy
Human immunodeficiency virus (HIV) epidemic has undoubtedly increased the incidence of tuberculosis (TB) globally, posing a formidable global health challenge affecting 1.2 million cases. Pulmonary TB assumes utmost significance in the programmatic perspective as it is readily transmissible as well as easily diagnosable. HIV complicates every aspect of pulmonary tuberculosis from diagnosis to treatment, demanding a different approach to effectively tackle both the diseases. In order to control these converging epidemics, it is important to diagnose early, initiate appropriate therapy for both infections, prevent transmission and administer preventive therapy...
September 26, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27903032/-interventional-left-atrial-appendage-closure-in-a-patient-with-gave-syndrome
#17
Christian Fastner, Sebastian Belle, Ibrahim Akin
History and findings | A 56-year-old female with a gastric antral vascular ectasia (GAVE) suffered from recurrent episodes of upper gastrointestinal bleeding. Because of a history of a permanent atrial fibrillation (CHA2DS2-VASc score 3 points) an oral anticoagulation therapy with phenprocoumon was carried out which even worsened the bleeding frequency and intensity. A change of medication to low-molecular weight heparin did not lead to success. The frequent periods in hospital limited the patient's quality of life...
November 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27902892/microrna-145-influences-the-balance-of-th1-th2-via-regulating-runx3-in-asthma-patients
#18
Linxia Fan, Xiaojun Wang, Linlan Fan, Qizhang Chen, Hong Zhang, Hui Pan, Aixia Xu, Hongjuan Wang, Yang Yu
AIM OF THE STUDY: To delineate the underlying mechanism of microRNA-145 modulate the balance of Th1/Th2 via targeting RUNX3 in asthma patients. MATERIALS AND METHODS: Peripheral blood samples were collected from asthma patients and healthy controls. CD4(+) T cells were isolated and cultured. Using quantitative PCR detect, the level of microRNA-145 and RUNX3 mRNA level in the CD4(+) T cells from asthma patients and healthy controls, meanwhile, western blot was used to detect the RUNX3 protein level...
November 30, 2016: Experimental Lung Research
https://www.readbyqxmd.com/read/27900649/brief-report-a-randomized-control-trial-assessing-the-influence-of-a-telephone-based-intervention-on-readmissions-for-patients-with-severe-mental-illness-in-a-developing-country
#19
U A Botha, L Koen, M Mazinu, E Jordaan, D J H Niehaus
Whilst comprehensive post-discharge interventions have been successful in reducing readmissions in our setting, they are possibly not sustainable due to limited resources. We assessed the impact of a more cost-effective telephone-based intervention on readmissions in a developing country over 12 months. 100 patients with severe mental illness were randomized to facilitated care or treatment as usual. All were interviewed prior to discharge and after 12 months. Facilitated care consisted of structured telephonic interviews and motivational support to patients and families...
November 30, 2016: Community Mental Health Journal
https://www.readbyqxmd.com/read/27898581/kinetics-of-plasma-triglycerides-in-abdominal-obesity
#20
Elias Björnson, Martin Adiels, Marja-Riitta Taskinen, Jan Borén
PURPOSE OF REVIEW: Abdominal obesity is associated with a number of important metabolic abnormalities including liver steatosis, insulin resistance and an atherogenic lipoprotein profile (termed dyslipidemia). The purpose of this review is to highlight recent progress in understanding the pathogenesis of this dyslipidemia. RECENT FINDINGS: Recent results from kinetic studies using stable isotopes indicate that the hypertriglyceridemia associated with abdominal obesity stems from dual mechanisms: (1) enhanced secretion of triglyceride-rich lipoproteins and (2) impaired clearance of these lipoproteins...
November 24, 2016: Current Opinion in Lipidology
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