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https://www.readbyqxmd.com/read/29778557/nanotechnological-foundations-of-a-%C3%A2-new%C3%A2-nephrology
#1
M Laura Sorian, Alberto Rodríguez-Benot, Miguel Valcárcel
After contextualising the generic frameworks of nanotechnology and nanomedicine, the 2disciplines are discussed in the field of Nephrology. The potential downside to nanonephrology is the renal clearance of nanoparticles, the use of which is ever-increasing both for nanomedicinal purposes and in nanofoods. The positive impact of nanotechnology in Nephrology is centred on the development of renal nanodiagnostics for basic renal function studies, the early diagnosis of acute kidney injury, reliable and simple follow-up of chronic kidney disease and the improvement of magnetic resonance imaging...
May 16, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29774663/dual-responsive-carbon-dot-for-ph-redox-triggered-fluorescence-imaging-with-controllable-photothermal-ablation-therapy-of-cancer
#2
Cheong A Choi, Jung Eun Lee, Zihnil Adha Islamy Mazrad, Young Kwang Kim, Insik In, Ji Hoon Jeong, Sung Young Park
We described fluorescence resonance energy transfer for pH/redox-activatable fluorescent carbon dot (FNP) to realize "off-on" switched imaging-guided controllable photothermal therapy (PTT). The FNP is a carbonized self-crosslinked polymer that allows IR825 loading (FNP[IR825]) via hydrophobic interactions in cancer therapy. The capability for fluorescence bioimaging was achieved via the internalization of FNP(IR825) into tumor cells, wherein glutathione (GSH) disulfide bonds were reduced and benzoic imine were cleaved under acidic conditions...
May 18, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29774316/dual-phase-adc-modelling-of-breast-masses-in-diffusion-weighted-imaging-comparison-with-histopathologic-findings
#3
Gökhan Ertaş, Can Onaygil, Onur Buğdaycı, Erkin Arıbal
Objective: To investigate the diagnostic value of dual-phase apparent diffusion coefficient (ADC) compared to traditional ADC values in quantitative diffusion-weighted imaging (DWI) for differentiating between benign and malignant breast masses. Materials and Methods: Diffusion-weighted images of pathologically confirmed 88 benign and 85 malignant lesions acquired using a 3.0T MR scanner were analyzed. Small region-of-interests focusing on the highest signal intensity of lesions were used...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29771327/propensity-score-matched-comparison-of-subcutaneous-and-transvenous-implantable-cardioverter-defibrillator-therapy-in-the-simple-and-effortless-studies
#4
Tom F Brouwer, Reinoud E Knops, Valentina Kutyifa, Craig Barr, Blandine Mondésert, Lucas V A Boersma, Pier D Lambiase, Nicholas Wold, Paul W Jones, Jeffrey S Healey
Aims: Comparison of outcomes between subcutaneous and transvenous implantable cardioverter-defibrillator (S-ICD and TV-ICD) therapy is hampered by varying patient characteristics and complication definitions. The aim of this analysis is to compare clinical outcomes of S-ICD and TV-ICD therapy in a matched cohort. Methods and results: Patients implanted with de novo implantable cardioverter-defibrillators without need for pacing were selected from two studies: SIMPLE (n = 1091 single and n = 553 dual chamber TV-ICDs) and EFFORTLESS (n = 798 S-ICDs)...
May 15, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29769130/diagnostic-accuracy-of-low-dose-dual-source-cardiac-computed-tomography-as-compared-to-surgery-in-univentricular-heart-patients
#5
Narumol Chaosuwannakit, Pattarapong Makarawate
BACKGROUND: To evaluate the ability of low radiation dose dual-source computed tomography (DSCT) to depict the features of morphological univentricular heart and to define accuracy by comparing findings with surgery. METHODS: Low radiation dose dual-source cardiac computed tomography (CCT) of 33 cases of functional univentricular heart preliminary diagnosis by echocardiography compared with the results of surgery were retrospectively analyzed (aged 1 day to 4 years, median 5 months)...
May 16, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29768112/-marvin-the-paranoid-android-the-case-of-an-alpha-pvp-user-in-the-expanding-galaxy-of-nps
#6
Simonato Pierluigi, Bulsis Laura, Negri Attilio, Bansal Gurjeet K, Pessa Gloria, Mioni Davide, Giuseppe Borgherini, Martinotti Giovanni, Schifano Fabrizio, Giulia Perini, Corazza Ornella
Alpha-PVP can be defined as a novel psychoactive substance (NPS)-more specifically, a novel synthetic cathinone with unpredictable stimulant effects in humans. "Marvin" arrived at a Dual Diagnosis Unit at Parco dei Tigli, Italy. He underwent a 30-day rehabilitation program to overcome his problematic Alpha-PVP use as a psychonaut. We conducted an online search to understand the properties of Alpha-PVP and its presence in scientific literature, reviewing official reports and the online drug market (e...
May 16, 2018: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/29762012/bio-inspired-cocatalysts-decorated-wo3-nanotube-toward-unparalleled-hydrogen-sulfide-chemiresistor
#7
Dong-Ha Kim, Ji-Soo Jang, Won-Tae Koo, Seon-Jin Choi, Hee-Jin Cho, Min-Hyeok Kim, Sang-Joon Kim, Il-Doo Kim
Herein, we incorporated dual bio-templates, i.e., cellulose nanocrystals (CNC) and apoferritin into electrospinning solution to achieve three distinct benefits, i.e., (i) facile synthesis of WO3 nanotube by utilizing self-agglomerating nature of CNC in the core of as-spun nanofibers, (ii) effective sensitization by partial phase transition from WO3 to Na2W4O13 induced by interaction between sodium doped CNC and WO3 during calcination, and (iii) uniform functionalization with monodispersive apoferritin-derived Pt catalytic nanoparticles (2...
May 15, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29756967/dual-energy-x-ray-absorptiometry-dxa-reliability-and-intraobserver-reproducibility-for-segmental-body-composition-measuring
#8
Osvaldo Costa Moreira, Claudia Eliza Patrocinio de Oliveira, José Antonio De Paz
BACKGROUND: the measurement precision of body composition can interfere on the diagnosis and prescription of diseases' treatment. Furthermore, with regard to dual energy X-rays absorptiometry (DXA), there may be important differences between the measures of regions of interest (ROI) automatically performed by DXA or manually by an evaluator, which can cause measurement error and influence the evaluation or diagnosis. AIM: thus, this study aimed to evaluate the measurement reliability of body composition by DXA and intraobserver reproducibility for the ROI measurement...
January 17, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29756295/treatment-outcomes-of-patients-with-primary-squamous-cell-carcinoma-of-the-retromolar-trigone
#9
Zain H Rizvi, Jose E Alonso, Edward C Kuan, Maie A St John
OBJECTIVES/HYPOTHESIS: Squamous cell carcinoma of the retromolar trigone (RMT SCC) is a relatively uncommon primary site for oral cavity malignancy. However, given its proximity to the mandible and buccal mucosa, RMT SCC typically exhibits early invasion and generally presents at an advanced stage. Large-sample studies are needed to assess the epidemiology and clinical outcomes of this tumor. Our aim was to describe the determinants of survival in patients with RMT SCC. STUDY DESIGN: Retrospective cohort study...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29752516/dual-tracer-tau-pet-imaging-reveals-different-molecular-targets-for-11-c-thk5351-and-11-c-pbb3-in-the-alzheimer-brain
#10
Konstantinos Chiotis, Per Stenkrona, Ove Almkvist, Vladimir Stepanov, Daniel Ferreira, Ryosuke Arakawa, Akihiro Takano, Eric Westman, Andrea Varrone, Nobuyuki Okamura, Hitoshi Shimada, Makoto Higuchi, Christer Halldin, Agneta Nordberg
PURPOSE: Several tau PET tracers have been developed, but it remains unclear whether they bind to the same molecular target on the heterogeneous tau pathology. In this study we evaluated the binding of two chemically different tau-specific PET tracers (11 C-THK5351 and 11 C-PBB3) in a head-to-head, in vivo, multimodal design. METHODS: Nine patients with a diagnosis of mild cognitive impairment or probable Alzheimer's disease and cerebrospinal fluid biomarker evidence supportive of the presence of Alzheimer's disease brain pathology were recruited after thorough clinical assessment...
May 12, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29750031/glypican-1-antibody-conjugated-gd-au-nanoclusters-for-fi-mri-dual-modal-targeted-detection-of-pancreatic-cancer
#11
Xin Huang, Chengqi Fan, Huanhuan Zhu, Wenjun Le, Shaobin Cui, Xin Chen, Wei Li, Fulei Zhang, Yong Huang, Donglu Sh, Zheng Cui, Chengwei Shao, Bingdi Chen
Introduction: Pancreatic cancer (PC) has a poor prognosis with high mortality, due to the lack of effective early diagnostic and prognostic tools. Materials and methods: In order to target and diagnose PC, we developed a dual-modal imaging probe using Glypican-1 (GPC-1) antibody conjugated with Gd-Au nanoclusters (NCs; Gd-Au-NC-GPC-1). GPC-1 is a type of cell surface heparan sulfate proteoglycan, which is often highly expressed in PC. The probe was successfully prepared with a hydrodynamic diameter ranging from 13...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29748869/classification-of-breast-masses-using-a-computer-aided-diagnosis-scheme-of-contrast-enhanced-digital-mammograms
#12
Gopichandh Danala, Bhavika Patel, Faranak Aghaei, Morteza Heidari, Jing Li, Teresa Wu, Bin Zheng
Contrast-enhanced digital mammography (CEDM) is a promising imaging modality in breast cancer diagnosis. This study aims to investigate how to optimally develop a computer-aided diagnosis (CAD) scheme of CEDM images to classify breast masses. A CEDM dataset of 111 patients was assembled, which includes 33 benign and 78 malignant cases. Each CEDM includes two types of images namely, low energy (LE) and dual-energy subtracted (DES) images. A CAD scheme was applied to segment mass regions depicting on LE and DES images separately...
May 10, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29747276/-relationship-between-vertebral-ct-values-and-bone-mineral-density-in-patients-with-chronic-obstructive-pulmonary-disease
#13
K Li, P Wang, R Y Yan, S J Song
Objective: To explore a simple method for early detection of osteoporosis in patients with chronic obstructive pulmonary disease (COPD), by analyzing the correlation between computed tomography (CT) values of the thoracolumbar vertebrae and dual energy X ray absorptiometry (DXA). Methods: 86 patients with acute exacerbation of COPD were included in this study. The average age of the patients, including 57 males and 29 females, was 74±10 years. They all received chest CT and DXA examination within 1 month after admission...
May 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29742737/inadvertent-defibrillator-lead-placement-into-the-left-ventricle-after-mitraclip-implantation-a-case-report
#14
Giuseppe Santarpia, Francesco Passafaro, Eugenia Pasceri, Annalisa Mongiardo, Antonio Curcio, Ciro Indolfi
RATIONALE: Inadvertent pacemaker/defibrillator lead placement into the left ventricle is an unusual cardiac device-related complication and its diagnosis is not always easy and often misunderstood. Thromboembolic events are frequently associated with this procedural complication. Percutaneous lead extraction should be performed when diagnosis is made early after device implantation while long-life oral anticoagulation is a wise option when the diagnosis is delayed and the lead is not removed...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29742524/prevalence-and-incidence-of-hepatitis-delta-in-patients-with-chronic-hepatitis-b-in-spain
#15
Antonio Aguilera, Rocio Trastoy, Javier Rodríguez-Calviño, Tamara Manso, Carmen de Mendoza, Vicente Soriano
BACKGROUND: Hepatitis delta virus (HDV) is a defective agent that only replicates in the presence of the hepatitis B virus. Accordingly, HDV acquisition may occur as superinfection of HBsAg+ carriers or following acute dual HDV and hepatitis B virus exposure. Herein, we examined the global and incident rates of HDV infections in Spain. PATIENTS AND METHODS: The presence of anti-HDV antibody and new HDV superinfections was examined in all HBsAg+ patients who attended one large tertiary outclinic in Spain since year 2000...
May 8, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29737837/redox-and-ph-dual-responsive-polymeric-micelle-with-aggregation-induced-emission-feature-for-cellular-imaging-and-chemotherapy
#16
Weihua Zhuang, Yangyang Xu, Gaocan Li, Jun Hu, Boxuan Ma, Tao Yu, Xin Su, Yunbing Wang
Intelligent polymeric micelles for tumor targeting antitumor drug delivery and bioimaging have drawn a broad attention due to the reduced systemic toxicity, enhanced efficacy of drugs and potential application of tumor diagnosis. Herein, we developed a multifunctional polymeric micelle system based on pH and redox dual responsive mPEG-P (TPE- co-AEMA) copolymer for stimuli triggered drug release and aggregation-induced emission (AIE) active imaging. These mPEG-P (TPE- co-AEMA) based micelles showed excellent biocompatibility and emission property, exhibiting great potential application for cellular imaging...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29736771/increased-prevalence-of-asymptomatic-vertebral-fractures-in-hiv-infected-patients-over-50-years-of-age
#17
Maria Llop, W A Sifuentes, S Bañón, C Macia-Villa, M J Perez-Elías, M Rosillo, S Moreno, M Vázquez, J L Casado
The prevalence of asymptomatic vertebral fracture in HIV-infected patients over 50 was 20%, associated with older age, male sex, longer time since HIV diagnosis, and tubular renal alterations. Vertebral fractures were independent of osteoporosis at lumbar spine, and were not predicted by the use of the FRAX equation. PURPOSE: Vertebral fractures (VF) are the hallmark of osteoporotic fractures. Our objective was to determine the prevalence of asymptomatic VF and associated factors in HIV-infected patients over 50 years, and the role of FRAX equation...
May 8, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29736206/mir-182-promotes-cell-proliferation-by-suppressing-fbxw7-and-fbxw11-in-non-small-cell-lung-cancer
#18
Hao Chang, Yue-Hong Liu, Li-Li Wang, Ju Wang, Zhi-Hong Zhao, Jun-Feng Qu, Sheng-Fa Wang
OBJECTIVE: MicroRNAs have been found to be deregulated in lung cancers, which play crucial roles in tumorigenesis and progression. FBXW7 and FBXW11, two important F-box proteins of the ubiquitin-proteasome system (UPS), can target multiple substrates for degradation, in order to regulate cell proliferation and survival in cancers. In the present study, we aimed to explore the potential role and regulating mechanism of miR-182 in non-small cell lung cancer (NSCLC). METHODS: MiRNA expression was evaluated by quantitative reverse-transcription polymerase chain reaction (qRT-PCR)...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29733202/dual-emissive-phosphorescent-polymer-probe-for-accurate-temperature-sensing-in-living-cells-and-zebrafish-using-ratiometric-and-phosphorescence-lifetime-imaging-microscopy
#19
Huajie Zhang, Jiayang Jiang, Pengli Gao, Tianshe Yang, Kenneth Yin Zhang, Zejing Chen, Shujuan Liu, Wei Huang, Qiang Zhao
Temperature plays an important part in many biochemical process. Accurate diagnosis and proper treatment usually depend on precise measurement of temperature. In this work, a dual-emissive phosphorescent polymer temperature probes, composed of iridium(III) complexes as temperature sensitive unit with phosphorescence lifetime of ~500 ns and europium(III) complexes as reference unit with lifetime of ~400 μs, has been rationally designed and synthesized. Upon the increase of the temperature, the luminescence intensity from the iridium(III) complexes enhances, while that from the europium(III) complexes keeps unchanged, which makes it possible for the ratiometric detection of temperature...
May 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29732104/dual-channel-fluorescence-diagnosis-of-cancer-cells-tissues-assisted-by-oatp-transporters-and-cysteine-glutathione
#20
Hongxing Zhang, Jing Liu, Bo Hu, Linfang Wang, Zhen Yang, Xu Han, Juanjuan Wang, Wei Bai, Wei Guo
Although fluorescence imaging diagnosis of the differences between cancer cells and normal cells by targeting ligand-based fluorescent probes is useful for recommending personalized therapy to patients, using the differences to diagnose a wide range of cancers is often not possible due to the genetic or phenotypic heterogeneity of cancer cells. In this work a 2-(diphenylphosphino)phenol-functionalized pyronin POP was presented as a dual-channel fluorescence agent for diagnosing a wide range of cancer cell types...
March 28, 2018: Chemical Science
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