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cro-magnon DNA

Gerald Forhan, Jean-Louis Martiel, Michael G B Blum
There is an ongoing debate in the field of human evolution about the possible contribution of Neanderthals to the modern human gene pool. To study how the Neanderthal private alleles may have spread over the genes of Homo sapiens, we propose a deterministic model based on recursive equations and ordinary differential equations. If the Neanderthal population was large compared to the Homo sapiens population at the beginning of the contact period, we show that genetic introgression should have been fast and complete meaning that most of the Neanderthal private alleles should be found in the modern human gene pool in case of ancient admixture...
November 2008: Mathematical Biosciences
David Caramelli, Lucio Milani, Stefania Vai, Alessandra Modi, Elena Pecchioli, Matteo Girardi, Elena Pilli, Martina Lari, Barbara Lippi, Annamaria Ronchitelli, Francesco Mallegni, Antonella Casoli, Giorgio Bertorelle, Guido Barbujani
BACKGROUND: DNA sequences from ancient specimens may in fact result from undetected contamination of the ancient specimens by modern DNA, and the problem is particularly challenging in studies of human fossils. Doubts on the authenticity of the available sequences have so far hampered genetic comparisons between anatomically archaic (Neandertal) and early modern (Cro-Magnoid) Europeans. METHODOLOGY/PRINCIPAL FINDINGS: We typed the mitochondrial DNA (mtDNA) hypervariable region I in a 28,000 years old Cro-Magnoid individual from the Paglicci cave, in Italy (Paglicci 23) and in all the people who had contact with the sample since its discovery in 2003...
2008: PloS One
Clive Gamble, William Davies, Paul Pettitt, Martin Richards
A link between climate change and human evolution during the Pleistocene has often been assumed but rarely tested. At the macro-evolutionary level Foley showed for hominids that extinction, rather than speciation, correlates with environmental change as recorded in the deep sea record. Our aim is to examine this finding at a smaller scale and with high-resolution environmental and archaeological archives. Our interest is in changing patterns of human dispersal under shifting Pleistocene climates during the last glacial period in Europe...
February 29, 2004: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
David Caramelli, Carles Lalueza-Fox, Cristiano Vernesi, Martina Lari, Antonella Casoli, Francesco Mallegni, Brunetto Chiarelli, Isabelle Dupanloup, Jaume Bertranpetit, Guido Barbujani, Giorgio Bertorelle
During the late Pleistocene, early anatomically modern humans coexisted in Europe with the anatomically archaic Neandertals for some thousand years. Under the recent variants of the multiregional model of human evolution, modern and archaic forms were different but related populations within a single evolving species, and both have contributed to the gene pool of current humans. Conversely, the Out-of-Africa model considers the transition between Neandertals and anatomically modern humans as the result of a demographic replacement, and hence it predicts a genetic discontinuity between them...
May 27, 2003: Proceedings of the National Academy of Sciences of the United States of America
M M de Pancorbo, M López-Martínez, C Martínez-Bouzas, A Castro, I Fernández-Fernández, G A de Mayolo, A A de Mayolo, P A de Mayolo, D J Rowold, R J Herrera
Polymorphic Alu insertions provide a set of DNA markers of interest in human population genetics. Approximately 1000-2000 of these insertions have not reached fixation within the human genome. Each one of these polymorphic loci most probably resulted from a unique insertional event, and therefore all individuals possessing the insertion are related by descent not just state. In addition, the direction of mutational change is toward the gain of the Alu element at a particular locus. Therefore, the improved knowledge of both the ancestral state and the direction of mutational change greatly facilitates the analysis of population relationships...
August 2001: Human Genetics
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