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https://www.readbyqxmd.com/read/29334723/methacholine-bronchial-provocation-test-in-patients-with-asthma-serial-measurements-and-clinical-significance
#1
Hyun-Jung Seo, Pureun-Haneul Lee, Byeong-Gon Kim, Sun-Hye Lee, Jong-Sook Park, Junehyuck Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park, An-Soo Jang
Background/Aims: The methacholine bronchial provocation test (MBPT) is used to detect and quantify airway hyper-responsiveness (AHR). Since improvements in the severity of asthma are associated with improvements in AHR, clinical studies of asthma therapies routinely use the change of airway responsiveness as an objective outcome. The aim of this study was to assess the relationship between serial MBPT and clinical profiles in patients with asthma. Methods: A total of 323 asthma patients were included in this study...
January 17, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29334720/-responding-to-national-strategy-demand-for-a-new-era-and-grasping-key-problems-of-basic-frontiers-in-preventive-medicine-shuangqing-forum-no-192-of-national-natural-science-foundation-of-china
#2
L Q Qin, C Q Yu, Y F Dai, A H Gu, Z W Zhang
No abstract text is available yet for this article.
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334711/-serologic-surveillance-indicators-analysis-among-syphilis-infected-pregnant-women-in-east-china
#3
L X Dou, Q Wang, X Y Wang, Y P Qiao, M Su, X Jin, A L Wang
Objective: To analyze serologic surveillance indicators during pregnancy among syphilis-infected women who delivered in 2013 in East China. Methods: Data were from national 'Information System of Prevention of Mother-to-child Transmission of HIV, syphilis and HBV Management' and in total 5 206 syphilis-infected pregnant women who delivered in 2013 and in East China were involved in the analysis. Information on demographic characters, laboratory tests, and treatment regimens were collected. The maternal non-treponemal testing surveillance and titer distribution were described and compare the proportions between pregnant women receiving standard testing and non-standard testing, taking baseline testing and testing before delivery or at the third trimester...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334707/-comparing-the-immunogenicity-and-safety-of-sequential-inoculation-of-sipv-followed-by-bopv-%C3%A2-%C3%A2-in-different-dosage-forms
#4
H Ye, T Huang, Z F Ying, G L Li, Y C Che, Z M Zhao, J F Wang, X L Yang, L Shi, R J Jiang, X C Liu, Z J Mo, C G Li, J S Yang
Objective: To compare the safety and immunogenicity of two different sequential schedules of inactivated poliomyelitis vaccine made from Sabin strain (sIPV) followed by typeⅠ+Ⅲ bivalent oral poliovirus vaccine (bOPV) in Drug Candy (DC) form or liquid dosage form). Methods: This randomized, blinded, single center, parallel-group controlled trial was done from September 2015 to June 2016 in Liuzhou, Guangxi province. Healthy infants aged ≥2 months were eligible for enrollment and divided into 1sIPV+2bOPV or 2sIPV+1bOPV sequential schedules...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334706/-analysis-of-mothers-acceptance-of-hpv-vaccination-of-adolescent-girls-in-xiamen
#5
Y F Han, Y N Zhuang, Y Li, Y Fang
Objective: To survey the mothers' acceptance of the HPV vaccination for their adolescent girls in Xiamen and to explore the influencing factors. Methods: Mothers of adolescent girls were selected by multistage cluster random sampling. Data of demography of the mothers and girls, the knowledge and attitude of cervical cancer and HPV vaccine of the mothers were collected. The influencing factors of mothers' attitudes were analyzed with univariate and multivariate logistic regression. Results: A total of 2 307 mothers were selected...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334702/-prevalence-of-calf-muscle-cramps-and-influencing-factors-for-pregnant-women-in-china-during-2010-2012
#6
Y F Duan, J Wang, S Jiang, Y Bi, X H Pang, S A Yin, Z Y Yang
Objective: To investigate the prevalence of calf muscle cramps and possible influencing factors for pregnant women in China. Methods: Using a multi-stage stratified probability proportional to size cluster randomization sampling method during 2010-2012. A total of 3 582 pregnant women were investigated at 150 counties from 31 provinces in China mainland. Information on calf muscle cramps, demographic socio-economic status, pregnancy information, and the physical activities was collected through questionnaires...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334675/effects-of-running-retraining-on-biomechanical-factors-associated-with-lower-limb-injury
#7
Marcus D Dunn, David B Claxton, Graham Fletcher, Jonathan S Wheat, David M Binney
Injury risk is an important concern for runners; however, limited evidence exists regarding changes to injury risk following running style retraining. Biomechanical factors, such as absolute peak free moment, knee abduction impulse, peak foot eversion and foot eversion excursion, have been shown to predict lower limb injury. The aim of this study was to assess the effects of Pose running retraining on biomechanical factors associated with lower limb running injury. Twenty uninjured recreational runners were pair-matched based on their five km run time performance and randomly assigned to control (n = 10) and intervention (three 2-h Pose running retraining sessions) groups (n = 10)...
January 12, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29334674/relationship-between-jumping-abilities-and-skeletal-muscle-architecture-of-lower-limbs-in-humans-systematic-review-and-meta-analysis
#8
J D Ruiz-Cárdenas, J J Rodríguez-Juan, J Ríos-Díaz
The aim of this study was to examine the influence of skeletal muscle architecture (SMA) features measured by 2-D ultrasonography on jumping performance in humans. A systematic review and meta-analysis was conducted, registry number: CRD42016043602. The scientific literature was systematically searched in eight databases, last run on March 14th, 2017. Cross-sectional studies focused on the association between SMA features and vertical jumping performance were selected. A random-effects model was used to analyze the influence of lower-limb SMA and maximal jump height...
January 12, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29334672/oxidative-and-interactive-challenge-of-cadmium-and-ocean-acidification-on-the-smooth-scallop-flexopecten-glaber
#9
Alessandro Nardi, Maura Benedetti, Daniele Fattorini, Francesco Regoli
Ocean acidification (OA) may affect sensitivity of marine organisms to metal pollution modulating chemical bioavailability, bioaccumulation and biological responsiveness of several cellular pathways. In this study, the smooth scallop Flexopecten glaber was exposed to various combinations of reduced pH (pH/pCO2 7.4/∼3000 μatm) and Cd (20 μg/L). The analyses on cadmium uptake were integrated with those of a wide battery of biomarkers including metallothioneins, single antioxidant defenses and total oxyradical scavenging capacity in digestive gland and gills, lysosomal membrane stability and onset of genotoxic damage in haemocytes...
January 8, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29334663/acute-toxicity-screening-of-different-extractions-components-and-constituents-of-polygonum-multiflorum-thunb-on-zebrafish-danio-rerio-embryos-in-vivo
#10
Jian-Bo Yang, Wan-Fang Li, Yue Liu, Qi Wang, Xian-Long Cheng, Feng Wei, Ai-Guo Wang, Hong-Tao Jin, Shuang-Cheng Ma
Polygonum multiflorum Thunb. has been used widely in East Asia in treatment of diseases associated with aging. However, there are many reports referred to the toxicity of P. multiflorum, especially for liver adverse reactions. The toxicity of it is caused by over dosage or by the herb itself remains unclear. The aim of this study was to study the toxicity of different extractions, components and constituents of P. multiflorum, which were assessed in zebrafish embryos. Firstly, the difference of extracting solvent to the toxicity of P...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29334659/serum-zinc-levels-in-acute-psychiatric-patients-a-case-series
#11
Peter Joe, Mara Getz, Samantha Redman, Matthew Petrilli, Thorsten Manfred Kranz, Samoon Ahmad, Dolores Malaspina
Zinc dysregulation is linked to neuropsychiatric disorders and a beneficial response to zinc supplementation has been demonstrated for depression. In this case series, we examined serum zinc levels with respect to clinical factors among 20 acutely ill psychiatric cases admitted to a large urban public hospital. The results showed frank clinical zinc insufficiency in a quarter of the subjects. Group-wise analyses showed a significant association between reduced serum zinc and diagnosis of depression, and reduced serum zinc in those with aggressive, assaultive, or violent behaviors...
January 6, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29334656/activated-protein-c-suppresses-osteoclast-differentiation-via-endothelial-protein-c-receptor-protease-activated-receptor-1-sphingosine-1-phosphate-receptor-and-apolipoprotein-e-receptor-2
#12
Kakunoshin Yoshida, Nobuyuki Akita, Takayuki Okamoto, Kunihiro Asanuma, Atsumasa Uchida, Akihiro Sudo, Motomu Shimaoka, Koji Suzuki, Tatsuya Hayashi
INTRODUCTION: Bone remodeling relies on a delicate balance between formation and resorption of bone tissues, processes in which bone-forming osteoblasts and bone-resorbing osteoclasts play central roles. Recently, we reported that anticoagulant activated protein C (APC) promotes osteoblast proliferation, but the role of the blood coagulation system in bone remodeling remains unclear. In this study, to further elucidate the relationship between bone remodeling and blood coagulation, we investigated the effect of APC on osteoclast differentiation...
January 3, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29334649/determining-variables-that-influence-the-phosphorus-content-of-waste-stabilization-pond-algae
#13
Matthew D Sells, Nicola Brown, Andrew N Shilton
Waste stabilization ponds (WSP) are one of the most common forms of wastewater treatment for smaller communities globally, but have poor phosphorus removal. It is known that WSP algae can accumulate polyphosphate within their cells in excess of that needed for cell function. If polyphosphate accumulation could be triggered at the higher range of WSP cell concentrations, phosphorus removal from domestic wastewater could be significantly improved. However, this phenomenon is sporadic and still not fully understood...
January 8, 2018: Water Research
https://www.readbyqxmd.com/read/29334642/examining-the-latent-structure-mechanisms-for-comorbid-posttraumatic-stress-disorder-and-major-depressive-disorder
#14
Margo C Hurlocker, Desirae N Vidaurri, Lisa-Ann J Cuccurullo, Kelly Maieritsch, C Laurel Franklin
BACKGROUND: Posttraumatic stress disorder (PTSD) is a complex psychiatric illness that can be difficult to diagnose, due in part to its comorbidity with major depressive disorder (MDD). Given that researchers have found no difference in prevalence rates of PTSD and MDD after accounting for overlapping symptoms, the latent structures of PTSD and MDD may account for the high comorbidity. In particular, the PTSD Negative Alterations in Cognition and Mood (NACM) and Hyperarousal factors have been characterized as non-specific to PTSD...
January 8, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29334636/impact-of-demographic-factors-on-the-antidepressant-effect-a-patient-level-data-analysis-from-depression-trials-submitted-to-the-pharmaceuticals-and-medical-devices-agency-in-japan
#15
Tetsuo Nakabayashi, Ayako Hara, Hirofumi Minami
A substantial and variable placebo response can cause unreliable findings in clinical trials designed to demonstrate the efficacy of antidepressants, and the high rate of failed trials represents a major obstacle in the development of new drugs for major depressive disorder (MDD). However, the influence of demographic and symptom factors on the antidepressant effect remains to be established. The purpose of this study was to estimate the magnitude of this influence. A patient-level meta-analysis of data from double-blind, randomized, placebo-controlled trials involving the use of antidepressants for adults with MDD was performed...
January 3, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29334621/taurine-as-a-green-bio-organic-catalyst-for-the-preparation-of-bio-active-barbituric-and-thiobarbituric-acid-derivatives-in-water-media
#16
Nader Daneshvar, Farhad Shirini, Mohaddeseh Safarpoor Nikoo Langarudi, Reyhaneh Karimi-Chayjani
Taurine, a β-amino acid that is abundantly available in the tissues of human and animals, is efficiently used as a green bio-organic catalyst in the preparation of some of the biologically active barbituric and thiobarbituric acid derivatives. In the presence of taurine, 5-Arylidene (thio) barbituric acid derivatives were prepared via Knovenagel reaction between aldehydes and (thio)barbituric acid. Using this reagent also pyrano[2,3-d]pyrimidinone(thione) derivatives were synthesized through a three-component reaction between aldehydes, (thio)barbituric and malononitrile...
December 21, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29334616/preoperative-breast-magnetic-resonance-imaging-use-by-breast-density-and-family-history-of-breast-cancer
#17
Louise M Henderson, Rebecca A Hubbard, Weiwei Zhu, Julie Weiss, Karen J Wernli, Martha E Goodrich, Karla Kerlikowske, Wendy DeMartini, Elissa M Ozanne, Tracy Onega
BACKGROUND: Use of preoperative breast magnetic resonance imaging (MRI) among women with a new breast cancer has increased over the past decade. MRI use is more frequent in younger women and those with lobular carcinoma, but associations with breast density and family history of breast cancer are unknown. MATERIALS AND METHODS: Data for 3075 women ages >65 years with stage 0-III breast cancer who underwent breast conserving surgery or mastectomy from 2005 to 2010 in the Breast Cancer Surveillance Consortium were linked to administrative claims data to assess associations of preoperative MRI use with mammographic breast density and first-degree family history of breast cancer...
January 15, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29334605/induction-chemotherapy-plus-concurrent-chemoradiotherapy-versus-concurrent-chemoradiotherapy-alone-in-locoregionally-advanced-nasopharyngeal-carcinoma-in-children-and-adolescents-a-matched-cohort-analysis
#18
Yang Li, Lin-Quan Tang, Li-Ting Liu, Shan-Shan Guo, Yu-Jing Liang, Xue-Song Sun, Qing-Nan Tang, Jin-Xin Bei, Jing Tan, Shuai Chen, Jun Ma, Chong Zhao, Qiu-Yan Chen, Hai-Qiang Mai
Purpose: The purpose of this study was to evaluate the long-term clinical outcome and toxicity of induction chemotherapy (IC) followed by concomitant chemoradiotherapy (CCRT) compared with CCRT alone for the treatment of children and adolescent locoregionally advanced nasopharyngeal carcinoma (LACANPC). Patients and Methods: A total of 194 locoregionally advanced NPC patients younger than 21 years who received CCRT with or without IC before were included in the study population...
January 8, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29334601/out-of-sight-but-no-longer-out-of-mind-towards-an-increased-recognition-of-the-role-of-soil-microbes-in-plant-speciation
#19
József Geml, Maggie R Wagner
No abstract text is available yet for this article.
February 2018: New Phytologist
https://www.readbyqxmd.com/read/29334582/carbohydrate-mouth-rinsing-does-not-prevent-the-decline-in-maximal-strength-following-fatiguing-exercise
#20
Christopher D Black, Daniel J Schubert, Marcin K Szczyglowski, Joshua D Wren
Carbohydrate (CHO) rinsing has been shown to attenuate the decline of maximal voluntary contractions (MVC) following fatiguing exercise-perhaps via a central mechanism. This study sought to determine the effect of a CHO rinse on MVC, voluntary activation, and contractile properties following fatiguing exercise. Thirteen adults participated in a double-blind, cross-over study. MVC of the dominant knee extensors was assessed and voluntary activation (%VA) was determined using twitch-interpolation. Participants then held 50% of MVC until volitional fatigue followed by a 20s rinse with a solution of 8% maltodextrin (CHO) or placebo (PLA)...
January 12, 2018: Journal of Strength and Conditioning Research
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