Yanfang Guan, Hong Hu, Yin Peng, Yuhua Gong, Yuting Yi, Libin Shao, Tengfei Liu, Gairui Li, Rongjiao Wang, Pingping Dai, Yves-Jean Bignon, Zhe Xiao, Ling Yang, Feng Mu, Liang Xiao, Zeming Xie, Wenhui Yan, Nan Xu, Dongxian Zhou, Xin Yi
Hereditary cancers occur because of inherited gene mutations. Genetic testing has been approved to provide information for risk assessment and rationale for appropriate intervention. Testing methods currently available for clinical use have some limitations, including sensitivity and testing throughput, etc. Next generation sequencing (NGS) has been rapidly evolving to increase testing sensitivity and throughput. It can be potentially used to identify inherited mutation in clinical diagnostic setting. Here we develop an effective method employing target enrichment and NGS platform to detect common as well as rare mutations for all common hereditary cancers in a single assay...
March 2015: Familial Cancer