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https://www.readbyqxmd.com/read/27899427/a-56-year-old-woman-with-breathlessness
#1
Alastair J Moss, Marc R Dweck, Peter D O'Kane
CLINICAL INTRODUCTION: A 56-year-old female with adult-onset asthma was admitted to the cardiology service with intermittent left-sided chest pain and progressive dyspnoea. Twelve months prior to this admission, she had received a course of prednisolone for bilateral anterior uveitis. Physical examination was unremarkable with blood sampling revealing a marked eosinophilia (eosinophil count 17.3×10(9)/L) and a perinuclear antineutrophil cytoplasmic antibody staining pattern on indirect immunofluorescence microscopy (myeloperoxidase antibodies 83 IU/mL)...
November 29, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27790333/a-multi-strain-synbiotic-may-reduce-viral-respiratory-infections-in-asthmatic-children-a-randomized-controlled-trial
#2
Hamid Ahanchian, Seyed Ali Jafari, Elham Ansari, Toktam Ganji, Mohammad Ali Kiani, Maryam Khalesi, Tooba Momen, Hamidreza Kianifar
BACKGROUND AND OBJECTIVE: Asthma is a growing problem worldwide. Acute exacerbations impose considerable morbidity, mortality, and increased cost. Viral respiratory infections are the most common cause (80-85%) of pediatric asthma exacerbations and admissions to the hospital. The aim of this study was to determine the effect of a new synbiotic Lactocare® on viral respiratory infections and asthma exacerbations in asthmatic children. METHODS: In this double blind, placebo-controlled, randomized clinical trial, 72 children with mild persistent asthma, aged between 6 and 12 years, were randomized to receive either Lactocare®, a Synbiotic containing 1 billion CFU/Capsule of Lactobacillus casei, Lactobacillus rhamnosus, Streptococcus thermophilus, Bifidobacterium breve, Lactobacillus acidophilus, Bifidobacterium infantis, Lactobacillus bulgaricus, and Fructooligosacharide (Zist Takhmir, Tehran, Iran) or placebo daily for 60 days...
September 2016: Electronic Physician
https://www.readbyqxmd.com/read/27695531/quantitative-determination-of-betamethasone-sodium-phosphate-and-betamethasone-dipropionate-in-human-plasma-by-uplc-ms-ms-and-a-bioequivalence-study
#3
Man-Yun Chen, Yong-Jun Tang, Yi-Cheng Wang, Chong-Zhi Wang, Chun-Su Yuan, Yao Chen, Zhi-Rong Tan, Wei-Hua Huang, Hong-Hao Zhou
The compound medicine of betamethasone sodium phosphate (BSP) and betamethasone dipropionate (BDP) is widely used for diverse glucocorticoid-sensitive acute and chronic diseases such as asthma, rheumatoid arthritis and systemic lupus erythematosus. It will be useful and beneficial to validate sensitive method for the determination of BSP, BDP and their metabolites for their pharmacokinetic study. Hereby, an ultra-high pressure liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has been validated for the determination of BSP, BDP and their metabolites betamethasone (BOH), betamethasone 17-monodipropionate (B17P) and betamethasone 21-monodipropionate (B21P) in human plasma...
May 7, 2016: Analytical Methods: Advancing Methods and Applications
https://www.readbyqxmd.com/read/27629962/isolated-adrenocorticotropin-deficiency-concomitant-with-graves-disease-a-case-report-and-literature-review
#4
Nobumasa Ohara, Masanori Kaneko, Hideyuki Kuriyama, Kazuhiro Sato, Hideki Katakami, Yutaka Oki, Kenzo Kaneko, Kyuzi Kamoi
A 73-year-old Japanese woman with untreated Graves' hyperthyroidism developed glucocorticoid-induced adrenal insufficiency (AI) after a supraphysiological dose of prednisolone therapy for bronchial asthma. Days later, she had high plasma adrenocorticotropic hormone (ACTH) levels and was expected to recover from glucocorticoid-induced AI. Her plasma ACTH levels remained high over 3 months during a physiological dose of hydrocortisone replacement. However, she suffered a further decrease in her serum cortisol level and was diagnosed with isolated adrenocorticotropin deficiency (IAD), in which bioinactive ACTH likely caused the high ACTH value...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27580552/igg4-related-lung-disease-associated-with-autoimmune-hemolytic-anemia-a-case-report-and-a-literature-review
#5
Shingo Noguchi, Kazuhiro Yatera, Mitsutaka Jinbo, Sohsuke Yamada, Ikuko Shimabukuro, Kei Yamasaki, Takashi Kido, Hiroshi Ishimoto, Chiharu Yoshii, Hiroshi Mukae
We herein report a case of IgG4-related lung disease (IgG4-RLD) associated with autoimmune hemolytic anemia (AIHA). A 73-year-old Japanese female visited our hospital for an examination following an abnormal chest X-ray in 1999. She was diagnosed with bronchiolitis and AIHA, and treatment with prednisolone was started. After seven years, she visited our department due to a cough. Chest computed tomography (CT) demonstrated focal consolidation with ground-glass attenuations and thickened bronchial walls in the bilateral lungs...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27540239/long-course-oral-corticosteroid-toxicity-in-children
#6
Fahad Aljebab, Imti Choonara, Sharon Conroy
BACKGROUND: Long courses of oral corticosteroids are commonly used in children in the management of conditions such as nephrotic syndrome, leukaemia, asthma and others. Various adverse drug reactions (ADRs) are known to occur with their use. This systematic review aimed to identify the most common and serious ADRs and to determine their relative risk levels. METHODS: A literature search of several databases; Embase, Medline, International Pharmaceutical Abstracts, CINAHL, the Cochrane Library and PubMed was performed to identify all studies where corticosteroids had been administered to paediatric patients ranging from 28 days to 18 years of age for at least 15 days of treatment...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27540233/tolerability-of-prednisolone-and-dexamethasone-in-children-in-saudi-arabia
#7
Fahad Aljebab, Mofadhi Alanazi, Imti Choonara, Sharon Conroy
BACKGROUND: Corticosteroids are used to treat a variety of medical conditions including acute asthma and croup where they are often given in short-courses. Epidemiological studies in Saudi Arabia show an increasing prevalence of respiratory diseases such as asthma in the past three decades.1 This study aimed to evaluate the tolerability and palatability of oral prednisolone and dexamethasone in children in Saudi Arabia. Both drugs are available in different formulations from different pharmaceutical companies...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27540214/a-really-wheezy-way-to-save-money
#8
Grace Li, Ofran Almossawi, Hasna Dulfeker, Vicky Jones, Felicity Taylor
AIM: To compare the palatability of oral non-soluble and oral soluble prednisolone tablets in paediatric patients admitted to the general paediatric wards in an acute London Trust. METHOD: As part of ongoing quality improvement initiatives, the Paediatric and Pharmacy departments compared tolerability of soluble versus non-soluble prednisolone in a group of 27 patients. Using a modified 5 point hedonic scale with 'smiley' faces we measured palatability and tolerance (swallowed versus refusal or vomiting) over two three week periods: the first period whilst soluble prednisolone was dispensed (n=17) and the second period after the switch to non-soluble prednisolone had been made (n=10)...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27264915/medication-palatability-affects-physician-prescribing-preferences-for-common-pediatric-conditions
#9
Hans Bradshaw, Michael J Mitchell, Christopher J Edwards, Uwe Stolz, Oday Naser, Amanda Peck, Asad E Patanwala
OBJECTIVES: The objective of this study was to determine if physicians would alter their prescribing preferences after sampling liquid formulations of medications for common pediatric diagnoses. METHODS: This was a prospective interventional before/after study conducted at an academic medical center in the United States. The participants of interest included emergency, family medicine, and pediatric physicians. Participants initially completed a brief survey for their primary oral liquid medication of choice for the treatment of selected disease states...
November 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27215329/interactive-digital-interventions-to-promote-self-management-in-adults-with-asthma-systematic-review-and-meta-analysis
#10
Gary McLean, Elizabeth Murray, Rebecca Band, Keith R Moffat, Peter Hanlon, Anne Bruton, Mike Thomas, Lucy Yardley, Frances S Mair
BACKGROUND: To identify, summarise and synthesise the evidence for using interactive digital interventions to support patient self-management of asthma, and determine their impact. METHODS: Systematic review with meta-analysis. We searched MEDLINE, EMBASE, CINAHL, PsycINFO, ERIC, Cochrane Library, DoPHER, TROPHI, Social Science Citation Index and Science Citation Index. The selection criteria requirement was studies of adults (16 years and over) with asthma, interventions that were interactive digital interventions and the comparator was usual care...
2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27176676/different-oral-corticosteroid-regimens-for-acute-asthma
#11
REVIEW
Rebecca Normansell, Kayleigh M Kew, George Mansour
BACKGROUND: Asthma is a common long-term breathing condition that affects approximately 300 million people worldwide. People with asthma may experience short-term worsening of their asthma symptoms; these episodes are often known as 'exacerbations', 'flare-ups', 'attacks' or 'acute asthma'. Oral steroids, which have a potent anti-inflammatory effect, are recommended for all but the most mild asthma exacerbations; they should be initiated promptly. The most often prescribed oral steroids are prednisolone and dexamethasone, but current guidelines on dosing vary between countries, and often among different guideline producers within the same country...
May 13, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27051141/eosinophilic-granulomatosis-with-polyangiitis-with-severe-pulmonary-hemorrhage-treated-with-rituximab
#12
S Baikunje, M Vankalakunti, V S Upadhyaya, G B Hosmane
Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by systemic vasculitis, asthma and eosinophilia. Severe pulmonary hemorrhage is rare. Renal involvement is seen in approximately 25% and can vary from isolated urinary abnormality to rapidly progressive glomerulonephritis. There is limited evidence to support the use of rituximab in this condition. We present a patient with EGPA who had severe pulmonary hemorrhage and rapidly progressive glomerulonephritis. He responded to standard treatment including prednisolone, cyclophosphamide, and plasma exchange...
March 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27043745/a-review-of-prednisolone-prescribing-for-children-with-acute-asthma-in-the-uk
#13
Francis J Gilchrist, Adil N Ahmad, Hannah K Batchelor, John F Marriott, Warren Lenney
INTRODUCTION: Worldwide asthma guidelines recommend short courses of oral prednisolone in children with acute exacerbations generating high prescription numbers. There is a paucity of evidence to inform the optimal dose and course duration. This has led to a variation in the recommendations for prednisolone prescribing. Our objective was to assess prednisolone prescribing practise for children with acute asthma in a representative sample of UK prescribers. METHODS: We developed an online questionnaire asking prescribers the prednisolone dosage, course duration and formulation used, whether they discussed oral prednisolone side effects with the family and at what child's age they changed from prescribing soluble to non-soluble formulations...
August 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27008817/budesonide-treatment-of-professional-athletes-and-anti-doping-testing-case-studies
#14
Paweł Kaliszewski, Danuta Kończak, Piotr Chołbiński, Mariola Wicka, Dorota Michalak, Dorota Kwiatkowska, Sylwia Lewandowska-Pachecka, Jacek Namieśnik, Andrzej Pokrywka
According to the World Anti-Doping Agency (WADA) Prohibited List, glucocorticosteroids are prohibited in competition and only when administered by oral, intravenous, intramuscular or rectal routes. Up to now, in order to differentiate whether glucocorticosteroids were administered by one of the prohibited routes or not, a specific reporting limit for urinary concentrations of parent compounds and their metabolites was established at 30 ng/mL. Additionally, the new specific regulation starting from 1 September 2014 for budesonide have been introduced that the 6β-hydroxybudesonide shall be targeted...
January 2016: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/26989530/successful-use-of-plasma-exchange-in-the-treatment-of-corticosteroid-refractory-eosinophilic-granulomatosis-with-polyangiitis-associated-with-gastrointestinal-manifestations
#15
Kohei Tsujimoto, Masato Yagita, Masashi Taniguchi, Masaaki Fujita
We describe the case of a 33-year-old woman having corticosteroid-refractory eosinophilic granulomatosis with polyangiitis (EGPA) who presented with abdominal pain and responded dramatically to plasma exchange. Eosinophilia, asthma history, neuropathy, pulmonary infiltrates, and paranasal sinus abnormalities confirmed the diagnosis of EGPA. Treatment was initiated with 1 g/day of methylprednisolone pulse therapy for 3 days followed by 60 mg/day of intravenous prednisolone without relieving abdominal pain...
2016: Case Reports in Immunology
https://www.readbyqxmd.com/read/26884413/asthma-in-an-adult-female-vervet-monkey-chlorocebus-sabaeus
#16
Liza S Köster, Bradley Simon, Gilda Rawlins, Amy Beierschmitt
A 9-y-old, colony-bred, female vervet monkey (Chlorocebus sabaeus) presented with a 6-y history of open-mouth breathing, tachypnea, and sibilant wheezing. These symptoms did not significantly affect her activity or quality of life. Thoracic radiographs and results of bronchoalveolar lavage supported the diagnosis of asthma. Treatment comprising intramuscular prednisolone (tapered over 2 mo from twice daily to every other day), inhaled salmeterol-fluticasone (25 μg-250 μg per actuation twice daily) by mask, and a metered dose inhaler was successful in restoring a normal respiratory pattern...
February 2016: Comparative Medicine
https://www.readbyqxmd.com/read/26844222/childhood-allergic-bronchopulmonary-aspergillosis-presenting-as-a-middle-lobe-syndrome
#17
Ashok Shah, Kamal Gera, Chandramani Panjabi
Allergic bronchopulmonary aspergillosis (ABPA) is infrequently documented in children with asthma. Although collapse is not uncommon, middle lobe syndrome (MLS) as a presentation of ABPA is rather a rarity. A 9-year-old female child with asthma presented with increase in intensity of symptoms along with a right midzone patchy consolidation on a chest radiograph. In addition, an ill-defined opacity abutting the right cardiac border with loss of cardiac silhouette was noted. A right lateral view confirmed a MLS, which was further corroborated by high resolution computed tomography...
January 2016: Asia Pacific Allergy
https://www.readbyqxmd.com/read/26770184/anti-inflammatory-effect-of-alloferon-on-ovalbumin-induced-asthma
#18
Jane Jeon, Yejin Kim, Hyemin Kim, Jae Seung Kang, Wang Jae Lee
Asthma is a well-known inflammatory lung disease; however, the specific underlying mechanism is largely unknown. We previously demonstrated that alloferon effectively downregulates pulmonary inflammation. In this study, we examined whether alloferon has a therapeutic effect on asthma. Alloferon remarkably decreased the number of eosinophils, macrophages, and neutrophils in the bronchoalveolar lavage fluid (BALF) from ovalbumin (OVA)-induced asthma mice. It was synergistically decreased with 2.5 mg/kg prednisolone (PDA)...
December 2015: Immune Network
https://www.readbyqxmd.com/read/26714414/prothrombotic-state-in-patients-with-severe-and-prednisolone-dependent-asthma
#19
Marlous M S Sneeboer, Christof J Majoor, Anne de Kievit, Joost C M Meijers, Tom van der Poll, Pieter W Kamphuisen, Elisabeth H Bel
BACKGROUND: Epidemiologic studies have shown that asthmatic patients, in particular those with severe disease, have increased risk of pulmonary embolism. It is unknown whether these patients have a prothrombotic state under stable conditions. OBJECTIVE: We sought to compare coagulation and fibrinolysis parameters between healthy subjects and patients with mild, severe, and prednisolone-dependent asthma under stable conditions and to investigate whether hemostatic markers correlate with airway inflammation...
December 20, 2015: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26640367/development-of-oral-dispersible-tablets-containing-prednisolone-nanoparticles-for-the-management-of-pediatric-asthma
#20
Yi-Dan Chen, Zhong-Yuan Liang, Yan-Yan Cen, He Zhang, Mei-Gui Han, Yun-Qiao Tian, Jie Zhang, Shu-Jun Li, Da-Sheng Yang
The purpose of the present study was to develop oral dispersible tablets containing prednisolone (PDS)-loaded chitosan nanoparticles using microcrystalline cellulose (MCC 101), lactose, and croscarmellose sodium (CCS). The PDS-loaded chitosan nanoparticles were formulated by ionotropic external gelation technique in order to enhance the solubility of PDS in salivary pH. Prepared nanoparticles were used for the development of oral fast disintegrating tablets by direct compression method. The prepared tablets were evaluated for disintegration time (DT), in vitro drug release (DR), thickness, weight variation, drug content uniformity, friability, and hardness...
2015: Drug Design, Development and Therapy
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