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Christina Williams, Alicia J Long, Heather Noga, Catherine Allaire, Mohamed A Bedaiwy, Sarka Lisonkova, Paul J Yong
STUDY OBJECTIVE: To investigate ethnic differences for moderate-to-severe endometriosis DESIGN: Analysis of a prospective registry, December 2013 - December 2016 ( # NCT02911090). INCLUSION CRITERIA: Women presenting to tertiary referral center for pelvic pain and/or endometriosis. EXCLUSION CRITERIA: Age greater than 50, menopausal, or mixed ethnicity. Logistic regression analysis was used to obtain adjusted odds ratios (aOR) and 95% confidence intervals (CI) adjusting for potential confounders (e...
June 20, 2018: Journal of Minimally Invasive Gynecology
P Collinet, X Fritel, C Revel-Delhom, M Ballester, P A Bolze, B Borghese, N Bornsztein, J Boujenah, T Brillac, N Chabbert-Buffet, C Chauffour, N Clary, J Cohen, C Decanter, A Denouël, G Dubernard, A Fauconnier, H Fernandez, T Gauthier, F Golfier, C Huchon, G Legendre, J Loriau, E Mathieu-d'Argent, B Merlot, J Niro, P Panel, P Paparel, C A Philip, S Ploteau, C Poncelet, B Rabischong, H Roman, C Rubod, P Santulli, M Sauvan, I Thomassin-Naggara, A Torre, J M Wattier, C Yazbeck, N Bourdel, M Canis
First-line diagnostic investigations for endometriosis are physical examination and pelvic ultrasound. The second-line investigations are: targeted pelvic examination performed by an expert clinician, transvaginal ultrasound performed by an expert physician sonographer (radiologist or gynaecologist), and pelvic MRI. Management of endometriosis is recommended when the disease has a functional impact. Recommended first-line hormonal therapies for the management of endometriosisrelated pain are combined hormonal contraceptives (CHCs) or the 52mg levonorgestrel-releasing intrauterine system (IUS)...
June 16, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Songnan Zhu, Yingjun Zhu, Yabo Liu, Hong Zhang
INTRODUCTION: Hormone therapy is widely used in the treatment of patients with ovarian endometriosis after surgery, and progestin and gonadotropin-releasing hormone (GnRH) are two of the most widely used hormones. This study aimed to compare the outcomes of progestin and GnRH in the treatment of ovarian endometriosis after surgery. METHODS: A total of 399 patients with ovarian endometriosis were included and divided into four groups to receive different treatments...
June 5, 2018: Advances in Therapy
Maria Elisabetta Coccia, Francesca Rizzello, Tommaso Capezzuoli, Paolo Evangelisti, Cinzia Cozzi, Felice Petraglia
To study whether unoperated ovarian endometrioma(s) or its surgical excision led to a modified pattern of ovarian decay with increasing female age. A sectional analysis of basal follicle stimulating hormone (FSH) and ovarian response to gonadotropins was conducted on women treated with fresh autologous In Vitro Fertilization/Intracytoplasmic sperm injection (IVF/ICSI) cycles. The study group included patients with unoperated ovarian endometrioma(s) (108 cycles); control groups were women with previous surgery for monolateral ovarian endometrioma (101 cycles), surgery for bilateral ovarian endometriomas (39 cycles), and tubal factor infertility (171 cycles)...
January 1, 2018: Reproductive Sciences
Jae Hoon Lee, Jae Yen Song, Kyong Wook Yi, Sa Ra Lee, Dong-Yun Lee, Jung-Ho Shin, SiHyun Cho, Seok Kyo Seo, Sung Hoon Kim
This study aimed to assess whether dienogest (DNG) is also effective in patients with recurrent endometriosis based on multicenter data of 121 women who were clinically diagnosed as having recurrent endometriosis and treated for more than 24 weeks with DNG (2 mg daily). We evaluated the changes in endometriosis-associated pain scores (visual analog scale [VAS]), serum cancer antigen 125 (CA-125) levels, and endometrioma sizes following DNG medication in these women along with adverse events associated with DNG medication...
January 1, 2018: Reproductive Sciences
Gustavo N Cecchino, Juan A García-Velasco
PURPOSE OF REVIEW: Surgery has traditionally been the primary treatment option for endometriosis-related infertility of any phenotype. However, advances and refinements of assisted reproductive technologies (ART) permit a more conservative approach in many scenarios. This review summarizes the latest findings in the field of reproductive medicine, which have supported a paradigm shift towards more conservative management of ovarian endometrioma. RECENT FINDINGS: The presence of ovarian endometrioma per se is likely to impair ovarian reserve and alter ovarian functional anatomy...
May 29, 2018: Current Opinion in Obstetrics & Gynecology
Abdullah Karaer, Gorkem Tuncay, Akın Mumcu, Berat Dogan
The purpose of this study was to investigate whether a change in the follicular fluid metabolomics profile due to endometrioma is identifiable. Twelve women with ovarian endometriosis (aged<40 years, with a body mass index [BMI] of <30 kg/m2 ) and 12 age- and BMI-matched controls (women with infertility purely due to a male factor) underwent ovarian stimulation for intracytoplasmic sperm injection (ICSI). Follicular fluid samples were collected from both of groups at the time of oocyte retrieval for ICSI...
May 28, 2018: Systems Biology in Reproductive Medicine
Jordina Munrós, Maria-Angeles Martínez-Zamora, Dolors Tàssies, Juan Carlos Reverter, Mariona Rius, Meritxell Gracia, Cristina Ros, Francisco Carmona
STUDY OBJECTIVE: To evaluate serial generation of microparticles (MPs) after laparoscopic stripping or CO2 laser vaporization in surgical treatment of patients with ovarian endometrioma (OE). DESIGN: A prospective, randomized, blinded, pilot study, including 30 patients (Canadian Task Force I). SETTING: Tertiary university hospital from December 2014 to July 2016. PATIENTS: 30 women with unilateral OE undergoing laparoscopic surgery...
May 24, 2018: Journal of Minimally Invasive Gynecology
Alessio Paffoni, Valentina Bolis, Stefania Ferrari, Laura Benaglia, Paolo Vercellini, Edgardo Somigliana
The present randomized controlled in vitro study was designed to evaluate the effects of the exposure of human cryopreserved oocytes to endometriotic fluid. Twenty-three women aged 36 (4) years donated a total of 147 vitrified supernumerary metaphase II oocytes. Warmed oocytes were randomly assigned to exposure to endometriotic fluid or unexposed control. Thereafter, oocytes were parthenogenetically activated and cultured for up to 5 days. The rate of activation on day 1 and the developmental rates on days 3 and 5 did not significantly differ between the 2 groups...
January 1, 2018: Reproductive Sciences
K Nahar, B Ferdous, N Akhter, P A Shamsunnahar, K Khatun, S A Begum, M A Aziz
Malignant transformation of ovarian endometriosis was first described in 1925 by Sampson; later on it has been described in extragonadal regions by few authors also. Ovarian endometrioid and clear cell carcinoma are highly associated with endometriosis. Here we present a case of malignant transformation of ovarian endometrioma into endometrioid adenocarcinoma and review the clinical and pathological features of these tumors. A 45-years old infertile woman diagnosed as a case of bilateral chocolate cyst with pelvic endometriosis underwent total hysterectomy with bilateral salpingo-oophorectomy...
April 2018: Mymensingh Medical Journal: MMJ
Laura Benaglia, Andrea Busnelli, Rossella Biancardi, Walter Vegetti, Marco Reschini, Paolo Vercellini, Edgardo Somigliana
RESEARCH QUESTION: What are the frequency, characteristics and consequences of technical diffiiculties encountered by physicians when carrying out oocyte retrieval in women with ovarian endometriomas? DESIGN: We prospectively recruited women undergoing IVF and compared technical difficulties between women with (n = 56) and without (n = 227) endometriomas. RESULTS: In exposed women, the cyst had to be transfixed in eight cases (14%, 95% CI 7 to 25%) and accidental contamination of the follicular fluid with the endometrioma content was recorded in nine women (16%, 95% CI 8 to 27%)...
April 13, 2018: Reproductive Biomedicine Online
Sefa Kurt, Hüseyin Aytuğ Avşar, Ömer Erbil Doğan, Hasan Bahadır Saatli, Uğur Saygılı
OBJECTIVE: Examining the cases of mature cystic teratoma (MCT) that are diagnosed and treated in our clinic regarding their association with fertility; and detecting the rate of malignant degeneration and the types of malignancies. MATERIAL AND METHODS: Patients, operated due to adnexal mass between April 2012 and August 2017 and diagnosed with MCT, were retrospectively examined. Mean age of the 80 cases, which met the criteria, was 30.60±10.5. 9 were suffering from infertility, according to hospital records...
May 14, 2018: Journal of the Turkish German Gynecological Association
Maxime Fastrez, Camille Marchisello, Marc Rassy, Serge Rozenberg, Nicolas Sirtaine
Three types of endometriosis are described: superficial peritoneal endometriosis (SPE), ovarian endometrioma (OMA), and deep infiltrating endometriosis (DIE). The expression of somatostatin receptors (SSTR1, 2, and 5) in human endometrial tissue and its ectopic form has been previously studied and may be different in each type of endometriosis. The aim of this study was to assess the immunohistochemical expression of SSTR1, 2, and 5 in tissue samples of SPE, OMA, and DIE. We performed a retrospective analysis in the pathology department database...
May 10, 2018: International Journal of Gynecological Pathology
Márcia Mendonça Carneiro, Luciana Maria Pyramo Costa, Maria Das Graças Torres, Patrícia Salomé Gouvea, Ivete de Ávila
We report the case of a 33 year-old woman who complained of severe dysmenorrhea since menarche. From 2003 to 2009, she underwent 4 laparoscopies for the treatment of pain associated with endometriosis. After all four interventions, the pain recurred despite the use of gonadotropin-releasing hormone (GnRH) analogues and the insertion of a levonorgestrel intrauterine system (LNG-IUS). Finally, a colonoscopy performed in 2010 revealed rectosigmoid stenosis probably due to extrinsic compression. The patient was advised to get pregnant before treating the intestinal lesion...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
Luisa Casadei, Francesca Dominici, Doriana Scaldaferri, Veronica Vicomandi, Susanna Ciacci, Emilio Piccione
This prospective study had the objective to compare anti-Müllerian hormone (AMH) serum levels among women with endometriomas and those with other benign ovarian cysts and verify a possible correlation between the AMH post-operative decline and the achievement of pregnancy. The study included 57 women undergoing laparoscopic surgery. Serum levels of AMH were measured preoperatively and at 6 and 12 months postoperatively. AMH serum levels decreased in both endometriomas and other benign cysts, but significant recovery was reported only in endometriomas (p = ...
May 4, 2018: Gynecological Endocrinology
Zhuowei Gu, Yifeng He, Yue Zhang, Mo Chen, Keqi Song, Yuting Huang, Qing Li, Wen Di
BACKGROUND: CA125 is a prevalently used serum biomarker for detecting ovarian cancer over the last three decades. However, it has a significant deficiency in screening for early-stage cancer. With the purpose of exploring an effective approach to improve its performance in early diagnosis, we investigated the postprandial fluctuation pattern of cancer-derived CA125 and the underlying mechanism. METHODS: In two medical centers, 551 patients sonographically diagnosed with ovarian (adnexal) cysts (< 5 cm in diameter) were enrolled and divided into five disease groups (pelvic inflammatory cysts, retention cysts, endometrioma, benign/borderline cystadenoma and malignant cysts)...
May 1, 2018: Journal of Translational Medicine
H Roman
Colorectal surgeons often participate in the multidisciplinary management of young females with endometriosis. Complications of endometriosis as well as its management often result in infertility since they can involve all pelvic organs including the procreative organs: uterus, ovaries and fallopian tubes. Complete excision of all endometriotic lesions should not be performed at the expense of irreversible destruction of the procreative organs; definitive infertility should not be the price to pay in order to obtain an improvement of the painful symptoms caused by endometriosis...
June 2018: Journal of Visceral Surgery
O Takaoka, T Mori, F Ito, H Okimura, H Kataoka, Y Tanaka, A Koshiba, I Kusuki, S Shigehiro, T Amami, J Kitawaki
Endometriosis is an estrogen-dependent disease, and isoflavones interact with estrogen receptors. The purposes of this study are to investigate the in vitro and in vivo effects of daidzein-rich isoflavone aglycones (DRIAs), dietary supplements, on cellular proliferation in endometriosis. Stromal cells isolated from ovarian endometrioma (OESCs) and normal endometrium (NESCs) were cultured with DRIAs, i.e., each of the DRIA components (daidzein, genistein, or glycitein), or isoflavone glycosides (IG; DRIA precursors)...
July 2018: Journal of Steroid Biochemistry and Molecular Biology
Omar Sow, William Valentin, Diouf Cheikh, Barboza Denis, Faye Samba Thiapato, Diallo Ibrahima, Gueye Serigne Modou Kane
Endometriosis is defined as the implantation of endometrial tissue outside of the uterine cavity. It affects approximately 10% of women of childbearing age. Umbilical endometriosis is rare and its pathophysiology is poorly known. We report the case of a 42-year old nulliparous female patient with a 5-year history of myomectomy, presenting with cyclic pain associated with umbilical mass. The diagnosis of umbilical endometrioma was made and confirmed by the histological examination of the surgical specimen. Treatment was based on wide excision of the mass associated with pelvis exploration and umbilical plasty...
2018: Pan African Medical Journal
Di Wu, Pan Lu, Xue Mi, Jinwei Miao
STUDY QUESTION: Is it possible to improve fibrosis in endometriosis by microRNA-214 delivery in exosomes? SUMMARY ANSWER: Upregulation of miR-214 may inhibit fibrogenesis and its delivery by exosomes derived from ectopic endometrial stromal cells, offers an alternative therapeutic approach for endometriosis fibrosis. WHAT IS KNOWN ALREADY: Fibrosis is the primary pathological feature of endometriosis. MiR-214 plays an important role in fibrotic disease...
April 11, 2018: Molecular Human Reproduction
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