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Endometrioma

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https://www.readbyqxmd.com/read/29208847/effect-of-etanercept-on-the-success-of-assisted-reproductive-technology-in-patients-with-endometrioma
#1
Göğşen Önalan, Yusuf Aytaç Tohma, Hulusi Bülent Zeyneloğlu
AIMS: To determine the effects of a tumor necrosis factor inhibitor (etanercept) on pregnancy outcomes in patients with endometrioma who were treated with assisted reproductive technology. METHODS: Sixty-eight infertile patients who had endometrioma were included in our retrospective case-control study. We administered etanercept (Enbrel, 50 mg in 1 mL intramuscularly) to 19 patients on the second day of their previous menstrual cycle. All patients were treated with assisted reproductive technology...
November 24, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29206943/time-to-redefine-endometriosis-including-its-pro-fibrotic-nature
#2
P Vigano, M Candiani, A Monno, E Giacomini, P Vercellini, E Somigliana
Endometriosis is currently defined as presence of endometrial epithelial and stromal cells at ectopic sites. This simple and straightforward definition has served us well since its original introduction. However, with advances in disease knowledge, endometrial stromal and glands have been shown to represent only a minor component of endometriotic lesions and they are often absent in some disease forms. In rectovaginal nodules, the glandular epithelium is often not surrounded by stroma and frequently no epithelium can be identified in the wall of ovarian endometriomas...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29205996/current-management-of-ovarian-endometriomas
#3
Ludovico Muzii, Chiara DI Tucci, Daniele DI Mascio, Mara DI Feliciantonio, Oriana Capri, Daniela Pietrangeli, Francesco Rech, Pierluigi Benedetti Panici
The choice of treatment in case of ovarian endometriomas is one of the most discussed topics in Reproductive Medicine. Management options include expectancy, medical treatment, surgery, in-vitro fertilization (IVF), or a combination of the above. The main presenting symptom, i.e. pain or infertility, usually guide the choice of treatment. Medical treatment is usually preferred as the first line option when pain is the associated symptom, whereas surgery or IVF are preferred in case of associated infertility...
December 4, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29203384/do-endometriomas-grow-during-ovarian-stimulation-for-assisted-reproduction-a-three-dimensional-volume-analysis-before-and-after-ovarian-stimulation
#4
Ayse Seyhan, Bulent Urman, Engin Turkgeldi, Baris Ata
Whether endometriomas grow because of supraphysiological oestradiol levels attained during ovarian stimulation for assisted reproduction techniques is a concern. In this prospective study, 25 women with 28 endometriomas underwent three-dimensional ultrasound using sono-automated volume calculation software. Endometrioma volume was measured on the first day of gonadotrophin injection (V1) and the day of ovulation trigger (V2). Nine (36%) women were stimulated in a gonadotrophin releasing hormone antagonist protocol (GnRH), 13 (52%) in a long, and three (12%) in an ultra-long GnRH agonist protocol...
November 17, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29200236/diagnostics-of-endometriosis-by-using-magnetic-resonance-imaging
#5
Eija Pääkkö, Maarit Niinimäki
Endometriosis affects about 2 to 10% of women in fertile age, It causes pain and infertility. In the ovaries, endometrios causes endometriomas. The disease may spread into the abdominal cavity and even result in ileus. Deep endometriomas are located under the peritoneal surface, typically behind the uterus and in the region of uterosacral ligaments. History, clinical examination and transvaginal ultrasound scanning usually lead to the diagnosis. Magnetic resonance imaging is in particular utilized prior to surgery...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29199174/endometrioma-of-the-sigmoid-colon-presenting-with-intestinal-obstruction
#6
Mustafa Kemal Demir, Taner Orug, Rahime Nida Bayık
No abstract text is available yet for this article.
November 30, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29194839/analysis-of-the-ectoenzymes-ada-alp-enpp1-and-enpp3-in-the-contents-of-ovarian-endometriomas-as-candidate-biomarkers-of-endometriosis
#7
Carla Trapero, Lluis Jover, Maria Eulàlia Fernández-Montolí, Amparo García-Tejedor, August Vidal, Inmaculada Gómez de Aranda, Jordi Ponce, Xavier Matias-Guiu, Mireia Martín-Satué
PROBLEM: The diagnosis of endometriosis, a prevalent chronic disease with a strong inflammatory component, is usually delayed due to the lack of noninvasive diagnostic tests. Purinergic signaling, a key cell pathway, is altered in many inflammatory disorders. The aim of the present work was to evaluate the levels of adenosine deaminase (ADA), alkaline phosphatase (ALP), ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), and ENPP3, elements of purinergic signaling, as biomarker candidates for endometriosis...
November 30, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29179885/bilaterality-of-ovarian-endometriomas-does-not-affect-the-outcome-of-in%C3%A2-vitro-fertilization-intracytoplasmic-sperm-injection-in-infertile-women-after-laparoscopic-cystectomy
#8
Hsing-Tse Yu, Hong-Yuan Huang, Hsiao-Jung Tseng, Chin-Jung Wang, Chyi-Long Lee, Yung-Kuei Soong
BACKGROUND: To assess whether the unilateral or bilateral lesions can affect ovarian reserve and pregnancy outcome in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in infertility patients underwent laparoscopic cystectomy. METHODS: A total of 148 IVF/ICSI cycle in patients who had undergone laparoscopic cystectomy for unilateral or bilateral endometriomas were reviewed retrospectively. There were 103 cycles where laparoscopic cystectomy had been carried out for unilateral endometriomas and 45 cycles after bilateral-side surgery...
October 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29174658/-management-of-endometrioma
#9
Pauline Chauvet, Horace Roman, Anne-Sophie Gremeau, Michel Canis, Nicolas Bourdel
Preoperative evaluation: clinical examination, and research for associated lesions. Laparoscopic approach. Cystectomy: gold standard, conformed to the endometrioma pathophysiology (3 zones). Laser CO2 Plasmajet® vaporisation: important data lead to legitimate utilisation. Haemostasis: be patient! Use of bipolar energy sparingly. Look for other endometriotic lesions, and systematic treatment. Preoperative medical treatment not always useful. Postoperative treatment: decrease recurrence. Especially for patients with no immediate pregnancy desire...
November 21, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29174167/progress-in-the-diagnosis-and-management-of-adolescent-endometriosis-an-opinion
#10
REVIEW
Giuseppe Benagiano, Sun-Wei Guo, Patrick Puttemans, Stephan Gordts, Ivo Brosens
Increasing evidence indicates that early onset endometriosis (EOE), starting around menarche or early adolescence, may have an origin different from the adult variant, originating from neonatal uterine bleeding (NUB). This implies seeding of naïve endometrial progenitor cells into the pelvic cavity with NUB; these can then activate around thelarche. It has its own pathophysiology, symptomatology and risk factors, warranting critical management re-evaluation. It can also be progressive, endangering future reproductive capacity...
October 25, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29171117/predictive-factors-for-emergent-surgical-intervention-in-patients-with-ovarian-endometrioma-hospitalized-for-pelvic-inflammatory-disease-a-retrospective-observational-study
#11
Reiko Matsuyama, Akira Tsuchiya, Osamu Nishii
AIM: The aim of this study was to identify predictive factors for emergent surgical interventions in patients with ovarian endometriomas hospitalized for pelvic inflammatory disease (PID). METHODS: We retrospectively identified 22 patients with ovarian endometriomas who were hospitalized to manage PID. Patients were divided into two groups: those who required emergent surgery after failed antibiotic therapy (emergent surgery group, n = 6) and those who were discharged with successful antibiotic therapy (conservative group, n = 16)...
November 24, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29161960/efficacy-and-safety-of-long-term-use-of-dienogest-in-women-with-ovarian-endometrioma
#12
Sa Ra Lee, Kyong Wook Yi, Jae Yen Song, Seok Kyo Seo, Dong-Yun Lee, SiHyun Cho, Sung Hoon Kim
Dienogest (DNG) is a progestin with highly selective progesterone activity and minimal androgenic activity and is helpful in reducing endometriosis-related pain. This study assessed the long-term efficacy and safety and recurrence rate of endometrioma with DNG use beyond 12 months of treatment. A retrospective cohort study was conducted with data collected from 7 university-affiliated hospitals and included a total of 514 women with ovarian endometrioma. All patients received 2 mg of oral DNG daily for at least 48 weeks postoperatively...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29160135/short-term-histopathological-effects-of-dienogest-therapy-on-ovarian-endometriomas-in-vivo-nonrandomized-controlled-trial
#13
Mohamed Mabrouk, Roberto Paradisi, Alessandro Arena, Simona Del Forno, Carlotta Matteucci, Letizia Zannoni, Giacomo Caprara, Renato Seracchioli
Ovarian endometriosis is a common gynecological disorder. To date, progestins are recommended as the first-line medical treatment for symptomatic ovarian endometriosis. The aim of this study was to evaluate the main histopathological effects of short-term dienogest therapy in patients with ovarian endometriomas scheduled for surgery. A prospective, nonrandomized controlled trial, including 70 symptomatic women with single ovarian endometriotic cyst (diameter between 30-50 mm) was conducted. Women scheduled for surgery were divided into two groups, depending on the treatment established at enrollment: 36 women received progestin therapy with dienogest (P group) and 34 women received no therapy (C group)...
November 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29136085/tgf-beta1-from-endometriomas-promotes-fibrosis-in-surrounding-ovarian-tissues-via-smad2-3-signaling
#14
Li Bing Shi, Feng Zhou, Hai Yan Zhu, Dong Huang, Xiao Ying Jin, Chao Li, Yongdong Dai, Yi Bin Pan, Song Ying Zhang
To elucidate whether the endometriotic cells of endometriomas synthesize transforming growth factor beta1 (TGF-beta1) and understand how it affects surrounding ovarian tissue. We collected biopsies of the cystic walls from 42 endometriomas and 29 mature teratomas and compared mRNA and protein expression of fibrosis-related factors between the cystic walls. Then we detected TGFB1 mRNA synthesis in endometriomas, and tested TGF-beta1 fibrotic effect in vitro. Moreover, we verified the expression of Smad2/3 Signaling components in the endometriotic cystic wall in order to understand whether TGF-beta1/Smad signaling is involved in fibrosis formation of the tissue surrounding endometriomas...
November 10, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29133081/-medical-treatment-of-endometriosis-hormonal-treatment-of-pain-impact-on-evolution-and-future-perspectives
#15
Sophie Geoffron, Guillaume Legendre, Emile Daraï, Nathalie Chabbert-Buffet
CONTEXT: Endometriosis is a chronic painful disease, for which hormone therapy is usually offered as a first line option to women not willing to conceive. OBJECTIVES: To analyse and synthesize the literature, from 2006 onwards, on pain control, and disease evolution in oemn using combined hormonal contraceptives, progestins and GnRH analogs. Data on other current and future treatment perspectives is included as well. SOURCES: Medline (Pubmed), the Cochrane Library, and endometriosis treatment recommendations published by European Society of Human Reproduction and Embryology (ESHRE), National Institute for health and Care Excellence (NICE), American College of Obstetricians and Gynecologists (ACOG), Royal College of Obstetricians and Gynaecologists (RCOG) and Société des Obstétriciens et Gynécologues du Canada (SOGC)...
November 10, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29129414/-surgical-management-of-deep-infiltrating-endometriosis-with-bowel-involvement-and-urinary-tract-involvement
#16
Sofiane Bendifallah, Marcos Ballester, Emile Darai
Endometriosis is a benign pathology that affects 3% of the general population and about 10% of women of reproductive age. Three anatomoclinical entities are described: peritoneal, ovarian (endometrioma) and deep endometriosis characterized by the infiltration of anatomical structures or organs beyond the peritoneum. Laparoscopic surgery should be performed, as this is associated with a reduction in postoperative complications, length of hospitalization and convalescence. Several surgical techniques allow the removal of deep endometriosis with colorectal involvement: rectal shaving, anterior discoid resection, segmental resection...
November 9, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29126882/the-role-of-mri-dti-in-predicting-pain-related-to-endometriosis-a-preliminary-study
#17
Maria Grazia Porpora, Valeria Vinci, Corrado De Vito, Giuseppe Migliara, Emanuela Anastasi, Adele Ticino, Serena Resta, Carlo Catalano, Pierluigi Benedetti Panici, Lucia Manganaro
OBJECTIVE: To evaluate the sacral nerve root features by the means of Magnetic Resonance Imaging Diffusion Tensor Imaging (MRI-DTI) tractography in women with endometriosis and /or adenomyosis and to analyze the correlation between DTI abnormalities, pain symptoms, and endometriotic lesions found at surgery. DESIGN: A cross-sectional, observational study (Canadian Task Force classification II-2) SETTING: University hospital PATIENTS: 76 women with clinical suspicion of endometriosis ...
November 7, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29112653/long-term-results-for-expectant-management-of-ultrasonographically-diagnosed-benign-ovarian-teratomas
#18
M Angela Pascual, Betlem Graupera, Cristina Pedrero, Ignacio Rodriguez, Silvia Ajossa, Stefano Guerriero, Juan Luis Alcázar
OBJECTIVE: To assess the natural history of ultrasonographically diagnosed benign ovarian teratomas in asymptomatic women. METHODS: We conducted a retrospective observational cohort study of 408 women (mean age 36.6 years, range 14-81 years) diagnosed as having an ovarian teratoma by transvaginal ultrasonography (except eight who only had a transabdominal study done) between January 2003 and December 2013 at a single tertiary care institution. Six hundred thirteen women were diagnosed with ovarian teratoma of whom 205 were promptly treated surgically, leaving 408 patients followed conservatively with follow-up scans at 3 and 6 months from diagnosis and then yearly...
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29081463/the-expression-of-cyclophilin-a-in-ovarian-endometrioma-its-correlation-with-recurrence-and-vascularity
#19
Akin Usta, Gulay Turan, Ertan Adali
Endometriosis is defined as the presence of functional endometrial tissues outside of the uterine cavity. Ovarian endometrioma is the most common type of endometriosis. It is an estrogen-dependent inflammatory disease that frequently causes infertility and chronic pelvic pain. Cyclophilin A (CyPA) is secreted from various types of cells in response to inflammatory stimuli. Many previous studies have shown that the increased expression and/or heightened plasma levels of CyPA exacerbates inflammation. The aim of this study is to evaluate CyPA immunoreactivity in ovarian endometrioma cyst wall...
October 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29074615/estrogen-is-an-important-mediator-of-mast-cell-activation-in-ovarian-endometriomas
#20
Tianhong Zhu, Shaojie Ding, Tiantian Li, Libo Zhu, Xiufeng Huang, Xinmei Zhang
Endometriosis is an estrogen-dependent disease. Previous research has shown that abnormal enzymes associated with estrogen (E2) metabolism and an increased number of mast cells (MCs) in endometriomas are implicated in pathogenesis of endometriosis. However, it remains unclear how MCs mediate the role of E2 in endometriosis. Accordingly, we investigated whether E2 was associated with the number of MCs, and the rate of degranulation, in local ovarian endometriomas, as well as the role of E2 on MCs during the pathogenesis of endometriosis...
October 26, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
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