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https://www.readbyqxmd.com/read/29327217/cryobiotechnology-of-apple-malus-spp-development-progress-and-future-prospects
#1
REVIEW
Min-Rui Wang, Long Chen, Jaime A Teixeira da Silva, Gayle M Volk, Qiao-Chun Wang
Cryopreservation provides valuable genes for further breeding of elite cultivars, and cryotherapy improves the production of virus-free plants in Malus spp., thus assisting the sustainable development of the apple industry. Apple (Malus spp.) is one of the most economically important temperate fruit crops. Wild Malus genetic resources and existing cultivars provide valuable genes for breeding new elite cultivars and rootstocks through traditional and biotechnological breeding programs. These valuable genes include those resistant to abiotic factors such as drought and salinity, and to biotic factors such as fungi, bacteria and aphids...
January 11, 2018: Plant Cell Reports
https://www.readbyqxmd.com/read/29315568/cryotherapy-not-as-cool-as-it-seems
#2
Shamara Nadarajah, Ramya Ariyagunarajah, Eric D Jong
In elite sports, a significant concern for many athletes is the ability to completely recover from prolonged exhaustive exercise. Athletes make use of numerous techniques to accelerate the healing process, priming their body for future events. Among the most common is the notion of muscle cooling, widely known as cryotherapy. This article is protected by copyright. All rights reserved.
January 6, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29314783/controlling-the-error-on-target-motion-through-real-time-mesh-adaptation-applications-to-deep-brain-stimulation
#3
Huu Phuoc Bui, Satyendra Tomar, Hadrien Courtecuisse, Michel Audette, Stéphane Cotin, Stéphane P A Bordas
An error-controlled mesh refinement procedure for needle insertion simulations is presented. As an example, the procedure is applied for simulations of electrode implantation for Deep Brain Stimulation. We take into account the brain shift phenomena occurring when a craniotomy is performed. We observe that the error in the computation of the displacement and stress fields is localised around the needle tip and the needle shaft during needle insertion simulation. By suitably and adaptively refining the mesh in this region, our approach enables to control, and thus to reduce, the error whilst maintaining a coarser mesh in other parts of the domain...
January 5, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29309463/transformation-of-benign-giant-cell-tumor-of-bone-into-epithelioid-angiosarcoma
#4
Carmen E Quatman, John H Alexander, Paul E Wakely, Joel L Mayerson
In this article, we report a case of transformation of a benign giant cell tumor (GCT) of the calcaneus into an epithelioid angiosarcoma. The patient presented to our service in 2003 and was followed until 2014. Transformation occurred 11 years after curettage, cryotherapy, cementation, and a well-documented disease-free interval. Longitudinal radiographs, magnetic resonance imaging, and histopathology were evaluated by the same medical team. There are only a few case reports and case series of malignancy associated with GCT of bone...
November 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29308602/anti-vascular-endothelial-growth-factor-vegf-drugs-for-treatment-of-retinopathy-of-prematurity
#5
REVIEW
Mari Jeeva Sankar, Jhuma Sankar, Parijat Chandra
BACKGROUND: Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis in foetal life. Researchers have recently attempted to use anti-VEGF agents for the treatment of retinopathy of prematurity (ROP), a vasoproliferative disorder. The safety and efficacy of these agents in preterm infants with ROP is currently uncertain. OBJECTIVES: To evaluate the efficacy and safety of anti-VEGF drugs when used either as monotherapy, that is without concomitant cryotherapy or laser therapy, or in combination with planned cryo/laser therapy in preterm infants with type 1 ROP (defined as zone I any stage with plus disease, zone I stage 3 with or without plus disease, or zone II stage 2 or 3 with plus disease)...
January 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29302149/epidemiological-trends-of-cutaneous-leishmaniasis-in-al-madinah-al-munawarah-province-western-region-of-saudi-arabia
#6
Miskelyemen Abdelatti Elmekki, Mogahid M Elhassan, Hani A Ozbak, Ilham T Qattan, Satti M Saleh, Ali H Alharbi
Objective: To investigate the epidemiological trends of cutaneous leishmaniasis (CL) in Al-Madinah Al-Munawarah, western region of KSA. Materials and Methods: Four hundred and sixty-seven parasitologically confirmed CL cases attending Al-Meeqat Hospital, Al-Madinah, during 2012-2015, were included in this study. Results: Both Saudi and non-Saudi nationals were infected, with the highest infection rate being among Saudis (68.7%). Males were more affected than females as 86...
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29296091/xanthelasma-palpebrarum-a-brief-review
#7
REVIEW
Pragya A Nair, Rochit Singhal
Xanthelasma palpebrarum is the most common cutaneous xanthoma, characterized by yellowish plaques over eyelids - most commonly, over the inner canthus of the upper lid. It is triggered by hyperlipidemia, thyroid dysfunction, and diabetes mellitus. Xanthelasma results from perivascular infiltration of mono- and multinucleated foam cells within lipid-laden cytoplasmic vacuoles in the superficial reticular dermis. Different modalities of treatment, such as simple surgical excision, cryotherapy, chemical peeling with trichloroacetic acid, radiofrequency, and laser, are used in the treatment of xanthelasma palpebrarum...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29290462/-retinal-hemangioblastoma-treatment-strategy-and-long-term-follow-up-in-a-retrospective-cohort
#8
A Lefevre, T Mathis, P Denis, L Kodjikian
INTRODUCTION: Retinal hemangioblastoma (RH) is a benign vascular tumor frequently associated with Von Hippel-Lindau disease (VHL). Tumor growth of RH may lead to deterioration of visual acuity, which can be difficult to treat. Early diagnosis may reduce complication rate and side effects of treatment. The present retrospective study evaluates the long-term follow-up and complications of RH treatment as a function of the therapeutic strategy used. MATERIALS AND METHODS: The study included patients with RH, followed at Croix Rousse university hospital, Lyon between 2010 and 2017...
December 28, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29284025/clinical-management-and-risk-reduction-in-women-with-low-grade-squamous-intraepithelial-lesion-cytology-a-population-based-cohort-study
#9
Yi-Jou Tai, Yun-Yuan Chen, Huang-Cheng Hsu, Chun-Ju Chiang, San-Lin You, Hui-Chi Chen, Chi-An Chen, Wen-Fang Cheng
We analyzed the management and risk of subsequent cervical intraepithelial neoplasm 3 (CIN3) and invasive cervical cancer in women with low-grade squamous intraepithelial lesion (LSIL) cytology. A total of 53,293 women with a new diagnosis of cytologic LSIL were identified in Taiwan's national cervical screening registration database. Based on the retrieved clinical management data, the incidence of subsequent CIN3+ lesions was determined, and the hazard ratios (HRs) were estimated using a Cox proportional hazards model...
2017: PloS One
https://www.readbyqxmd.com/read/29283124/topical-chemotherapy-for-giant-ocular-surface-squamous-neoplasia-of-the-conjunctiva-and-cornea-is-surgery-necessary
#10
Sonal S Chaugule, Jennifer Park, Paul T Finger
PURPOSE: The purpose of this study is to report on the efficacy and safety of topical chemotherapy alone for giant ocular surface squamous neoplasia (OSSN). METHODS: In this retrospective, interventional series, 10 eyes with giant OSSN underwent exfoliative biopsy to confirm the diagnosis followed by application of interferon alpha 2b (IFN α2b) and/or 5 fluorouracil, 1% (5FU). Reported outcome measures were tumor response, visual acuity, recurrence, systemic metastasis, and treatment complications...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29279655/outcomes-of-pneumatic-retinopexy-for-the-management-of-rhegmatogenous-retinal-detachment-at-a-tertiary-care-center
#11
Mohammad A Hazzazi, Saba Al Rashaed
PURPOSE: The purpose of the study was to report the outcomes of pneumatic retinopexy (PR) for rhegmatogenous retinal detachment (RRD). METHODS: A retrospective chart review of all patients with RRD who were managed with PR at the King Khaled Eye Specialist Hospital between 2000 and 2014. Data were collected on preoperative ocular history, characteristics of the RRD, postoperative anatomical and visual outcomes, and secondary surgeries. RESULTS: Sixty-five eyes comprised the study sample with mean a follow-up of 42 months...
July 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29277657/effects-of-focal-versus-total-cryotherapy-and-minimum-tumor-temperature-on-patient-reported-quality-of-life-as-compared-to-active-surveillance-in-prostate-cancer-patients
#12
Glenn T Werneburg, Michael Kongnyuy, Daniel M Halpern, Jose M Salcedo, Connie Chen, Amanda LeSueur, Kaitlin E Kosinski, Jeffrey T Schiff, Anthony T Corcoran, Aaron E Katz
OBJECTIVE: To investigate the effects of focal (hemiablation) or total cryotherapy and minimum tumor temperature on patient-reported quality of life (QoL) in prostate cancer patients. METHODS: An IRB-approved database was reviewed for patients who underwent cryotherapy or active surveillance (AS). QoL questionnaire responses were collected and scores were analyzed for differences between focal versus total cryotherapy and very cold (<-76° C) versus moderate-cold (≥-76°C) minimum tumor temperatures...
December 22, 2017: Urology
https://www.readbyqxmd.com/read/29277585/a-comparison-of-time-taken-to-return-to-baseline-erectile-function-following-focal-and-whole-gland-ablative-therapies-for-localized-prostate-cancer-a-systematic-review
#13
REVIEW
Nicholas A Faure Walker, Joseph M Norris, Taimur T Shah, Tet Yap, Paul Cathcart, Caroline M Moore, Hashim U Ahmed, Mark Emberton, Suks Minhas
OBJECTIVES: To systematically review erectile function (EF) outcomes following primary whole gland (WG) and focal ablative therapies for localized prostate cancer to ascertain whether the treatment modality or intended treatment volume affects the time taken to recover baseline EF. METHOD AND MATERIALS: A systematic review was performed according to the preferred reporting items for systematic review and meta-analysis statement. Inclusion criteria were men with localized prostate cancer treated with primary, ablative therapy...
December 22, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29273103/emerging-unconventional-therapies-for-alopecia-areata
#14
Natasha Atanaskova Mesinkovska
Alopecia areata is a prevalent autoimmune skin disease with no cure or indicated treatment options. In the absence of an approved treatment, some patients are eager to try unconventional therapies, despite the very limited research evaluating their safety and efficacy. Recently emerging unconventional therapies for alopecia areata discussed include antihistamines, cryotherapy, and low-dose naltrexone.
January 2018: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/29247029/time-to-effect-based-dosing-strategy-for-cryoballoon-ablation-in-patients-with-paroxysmal-atrial-fibrillation-results-of-the-plusone-multicenter-randomized-controlled-noninferiority-trial
#15
RANDOMIZED CONTROLLED TRIAL
Ángel Ferrero-de-Loma-Osorio, Amaya García-Fernández, Jesús Castillo-Castillo, Maite Izquierdo-de-Francisco, Alicia Ibáñez-Críado, Jose Moreno-Arribas, Angel Martínez, Vicente Bertomeu-González, Patricia López-Mases, María Ajo-Ferrer, Carlos Núñez, Lourdes Bondanza-Saavedra, Juan Miguel Sánchez-Gómez, Juan Gabriel Martínez-Martínez, Francisco Javier Chorro-Gascó, Ricardo Ruiz-Granell
BACKGROUND: The optimal dosage of cryotherapy during cryoballoon ablation of pulmonary veins is still unclear. This trial tested the noninferiority of a novel, individualized, cryotherapy-dosing strategy for each vein. METHODS AND RESULTS: This prospective, randomized, multicenter, noninferiority study included 140 patients with paroxysmal atrial fibrillation, which was refractory to antiarrhythmic drugs. Patients were randomly assigned to a conventional strategy of 180-second cryoballoon applications per vein with a bonus freeze (control group, n=70) or to a shorter-time application protocol, with 1 application that lasted the time required for electric block time to effect plus 60- and a 120-second freeze bonus (study group, n=70)...
December 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29243490/percutaneous-cryoablation-of-breast-tumors-in-patients-with-stable-metastatic-breast-cancer-safety-feasibility-and-efficacy
#16
H Beji, F Pilleul, R Picard, O Tredan, A Bouhamama, M Peix, E Mavrovi, C Mastier
PURPOSE: To evaluate safety, feasibility, and efficacy of percutaneous cryoablation of breast tumors in patients with clinically stable metastatic breast cancer, and to compare the findings with reports on alternative procedures, namely surgery and local radiotherapy. METHODS: Seventeen female patients (average age of 54.8 years +/- 10.8 ; range 37-72) with primary breast tumor not surgically treated because of metastatic disease were included. Patients were treated for their primary lesion by percutaneous cryotherapy in period of stable disease...
December 15, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29242258/ers-statement-interventional-bronchoscopy-in-children
#17
Ernst Eber, Juan L Antón-Pacheco, Jacques de Blic, Iolo Doull, Al Faro, Raffaella Nenna, Thomas Nicolai, Petr Pohunek, Kostas N Priftis, Paola Serio, Courtney Coleman, Sarah Masefield, Thomy Tonia, Fabio Midulla
Paediatric airway endoscopy is accepted as a diagnostic and therapeutic procedure, with an expanding number of indications and applications in children. The aim of this European Respiratory Society task force was to produce a statement on interventional bronchoscopy in children, describing the evidence available at present and current clinical practice, and identifying areas deserving further investigation. The multidisciplinary task force panel performed a systematic review of the literature, focusing on whole lung lavage, transbronchial and endobronchial biopsy, transbronchial needle aspiration with endobronchial ultrasound, foreign body extraction, balloon dilation and occlusion, laser-assisted procedures, usage of airway stents, microdebriders, cryotherapy, endoscopic intubation, application of drugs and other liquids, and caregiver perspectives...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29241743/glaucoma-after-lens-sparing-vitrectomy-for-advanced-retinopathy-of-prematurity
#18
Eric Nudleman, Ilkay Kilic Muftuoglu, Raouf Gaber, Joshua Robinson, Kimberly Drenser, Antonio Capone, Michael T Trese
PURPOSE: To report the incidence of, and factors related to, glaucoma after lens-sparing vitrectomy (LSV) surgery in advanced retinopathy of prematurity (ROP). DESIGN: Retrospective case series at a single tertiary referral pediatric vitreoretinal practice. PARTICIPANTS: Four hundred and one eyes from 270 patients were included. METHODS: The medical records of patients who underwent LSV for stage 4A, 4B, and 5 ROP were retrospectively reviewed...
December 11, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29240822/acne-keloidalis-nuchae-in-asian-a-single-institutional-experience
#19
Kiyong Na, Sang Ho Oh, Sang Kyum Kim
Acne keloidalis nuchae, a type of folliculitis involving the back of the neck, is common in black men, although rare cases have been reported in patients of other ethnicities. We analyzed the clinicopathological features of acne keloidalis nuchae in 17 Asians. Patients' age at the time of presentation ranged from 20 to 69 years. Most patients experienced the disease over 2 years (range, 3 months-20 years); follow-up data were available for 11 (65%) patients (range, 2-95 months). Nine (53%) patients had comorbidities, but none had a history of other skin disease or a family history of acne keloidalis nuchae...
2017: PloS One
https://www.readbyqxmd.com/read/29238232/efficacy-of-thermoablation-in-treating-cervical-precancerous-lesions-in-a-low-resource-setting
#20
Phuong Lien Tran, Bruno Kenfack, Eveline Tincho Foguem, Manuela Viviano, Liliane Temogne, Pierre-Marie Tebeu, Rosa Catarino, Anne-Caroline Benski, Pierre Vassilakos, Patrick Petignat
Introduction: Treating cervical intraepithelial neoplasia (CIN) grades 2 and 3 is the recommended strategy for preventing invasive carcinoma in low- and middle-income countries (LMICs). Our objective was to assess the efficacy of thermoablation in the treatment of CIN2 and CIN3 in a screen-and-treat approach. Methods: Women aged 30-49 years in Dschang, Cameroon, were invited to undergo vaginal sampling for human papillomavirus (HPV), samples being assessed by an Xpert HPV Assay...
2017: International Journal of Women's Health
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