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JOURNAL ARTICLE
Xinyu Wang, Meiyuan Zeng, Xueming Ju, Anqi Lin, Chaozheng Zhou, Junyi Shen, Zaoqu Liu, Bufu Tang, Quan Cheng, Youyu Wang, Jian Zhang, Peng Luo
BACKGROUND: Many survivors of a first primary cancer (FPCs) are at risk of developing a second primary cancer (SPC), with effects on patient prognosis. Primary cancers have different frequencies of specific SPC development and the development of SPCs may be closely related to the FPC. The aim of this study was to explore possible correlations between SPCs and FPCs. METHODS: Relevant literature on SPCs was retrospectively searched and screened from four databases, namely, PubMed, EMBASE, Web of Science, and PMC...
January 3, 2024: British Journal of Surgery
#22
REVIEW
Alphonce M K Nyalali, Angela U Leonard, Yongxiang Xu, Huayu Li, Junlin Zhou, Xinrui Zhang, Tibera K Rugambwa, Xiaohan Shi, Feng Li
CD147 also known as EMMPRIN, basigin, and HAb18G, is a single-chain type I transmembrane protein shown to be overexpressed in aggressive human cancers of CNS, head and neck, breasts, lungs, gastrointestinal, genitourinary, skin, hematological, and musculoskeletal. In these malignancies, the molecule is integral to the diverse but complimentary hallmarks of cancer: it is pivotal in cancerous proliferative signaling, growth propagation, cellular survival, replicative immortality, angiogenesis, metabolic reprogramming, immune evasion, invasion, and metastasis...
2023: Frontiers in Oncology
#23
JOURNAL ARTICLE
Fiona C Malcomson, Solange Parra-Soto, Frederick K Ho, Liya Lu, Carlos Celis-Morales, Linda Sharp, John C Mathers
BACKGROUND: The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) Cancer Prevention Recommendations are lifestyle-based recommendations which aim to reduce cancer risk. This study investigated associations between adherence, assessed using a standardised scoring system, and the risk of all cancers combined and of 14 cancers for which there is strong evidence for links with aspects of lifestyle in the UK. METHODS: We used data from 94,778 participants (53% female, mean age 56 years) from the UK Biobank...
November 28, 2023: BMC Medicine
#24
JOURNAL ARTICLE
Shufa Zhao, Yuntao Li, Jie Xu, Liang Shen
BACKGROUND: Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) type 3C (A3C) has been identified as a cancer molecular biomarker in the past decade. However, the practical role of A3C in lower-grade gliomas (LGGs) in improving the clinical outcome remains unclear. This study aims to discuss the function of A3C in immunotherapy in LGGs. METHODS: The RNA-Sequencing (RNA-seq) and corresponding clinical data were extracted from UCSC Xena and the results were verified in the Chinese Glioma Genome Atlas (CGGA)...
November 26, 2023: Neurological Research
#25
REVIEW
Minocycline as a prospective therapeutic agent for cancer and non-cancer diseases: a scoping review.
Abedeh Rezaei, Amin Moqadami, Mohammad Khalaj-Kondori
Minocycline is an FDA-approved secondary-generation tetracycline antibiotic. It is a synthetic antibiotic having many biological effects, such as antioxidant, anti-inflammatory, anti-cancer, and neuroprotective functions. This study discusses the pharmacological mechanisms of preventive and therapeutic effects of minocycline. Specifically, it provides a comprehensive overview of the molecular pathways by which minocycline acts on the different cancers, including ovarian, breast, glioma, colorectal, liver, pancreatic, lung, prostate, melanoma, head and neck, leukemia, and non-cancer diseases such as Alzheimer's disease, Parkinson, schizophrenia, multiple sclerosis, Huntington, polycystic ovary syndrome, and coronavirus disease 19...
November 22, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
#26
JOURNAL ARTICLE
Jianxuan Sun, Jiacheng Xiang, Ye An, Jinzhou Xu, Yifan Xiong, Shaogang Wang, Qidong Xia
INTRODUCTION: More and more studies have focused on the associations between human papillomavirus (HPV) infection and pan-cancers. However, current evidence is largely based on retrospective studies, which are susceptible to confounding factors and do not enable the establishment of causal relationships. METHODS: A bidirectional two-sample Mendelian randomization (MR) design was employed to thoroughly evaluate the causal relationships between HPV and 12 site-specific cancers except cervical cancer...
October 26, 2023: Cancers
#27
Yadong Zhang, Liyi Rong, Zhiqiang Wang, Hongfu Zhao
OBJECTIVE: The purpose of this scoping review was to explore the top 100 most cited articles in helical tomotherapy (HT) through bibliometric analysis and visualization tools, help researchers comprehensively understand the research hotspots of HT, and provide clear and intuitive network visualization. METHODS: The Web of Science Core Collection and the search strategy of "Title (TI)=(tomotherapy)" were used to search for articles related to HT as of 27 May 2023...
2023: Frontiers in Oncology
#28
JOURNAL ARTICLE
Elnaz Naderi, Miguel E Aguado-Barrera, Line M H Schack, Leila Dorling, Tim Rattay, Laura Fachal, Holly Summersgill, Laura Martínez-Calvo, Ceilidh Welsh, Tom Dudding, Yasmin Odding, Ana Varela-Pazos, Rajesh Jena, David J Thomson, Roel J H M Steenbakkers, Joe Dennis, Ramón Lobato-Busto, Jan Alsner, Andy Ness, Chris Nutting, Antonio Gómez-Caamaño, Jesper G Eriksen, Steve J Thomas, Amy M Bates, Adam J Webb, Ananya Choudhury, Barry S Rosenstein, Begona Taboada-Valladares, Carsten Herskind, David Azria, David P Dearnaley, Dirk de Ruysscher, Elena Sperk, Emma Hall, Hilary Stobart, Jenny Chang-Claude, Kim De Ruyck, Liv Veldeman, Manuel Altabas, Maria Carmen De Santis, Marie-Pierre Farcy-Jacquet, Marlon R Veldwijk, Matthew R Sydes, Matthew Parliament, Nawaid Usmani, Neil G Burnet, Petra Seibold, R Paul Symonds, Rebecca M Elliott, Renée Bultijnck, Sara Gutiérrez-Enríquez, Meritxell Mollà, Sarah L Gulliford, Sheryl Green, Tiziana Rancati, Victoria Reyes, Ana Carballo, Paula Peleteiro, Paloma Sosa-Fajardo, Chris Parker, Valérie Fonteyne, Kerstie Johnson, Maarten Lambrecht, Ben Vanneste, Riccardo Valdagni, Alexandra Giraldo, Mónica Ramos, Brenda Diergaarde, Geoffrey Liu, Suzanne M Leal, Melvin L K Chua, Miranda Pring, Jens Overgaard, Luis M Cascallar-Caneda, Fréderic Duprez, Christopher J Talbot, Gillian C Barnett, Alison M Dunning, Ana Vega, Christian Nicolaj Andreassen, Johannes A Langendijk, Catharine M L West, Behrooz Z Alizadeh, Sarah L Kerns
BACKGROUND: This study was designed to identify common genetic susceptibility and shared genetic variants associated with acute radiation-induced toxicity (RIT) across four cancer types (prostate, head and neck, breast, and lung). METHODS: A GWAS meta-analysis was performed using 19 cohorts including 12,042 patients. Acute standardized total average toxicity (rSTATacute) was modelled using a generalized linear regression model for additive effect of genetic variants adjusted for demographic and clinical covariates...
October 20, 2023: JNCI Cancer Spectrum
#29
REVIEW
Farid Najafi, Fatemeh Rajati, Diana Sarokhani, Maryam Bavandpour, Mehdi Moradinazar
BACKGROUND: Considering that metformin is widely used in the treatment of diabetes, and its protective role against various malignancies, the strength and validity of the available evidence from related systematic reviews and meta-analysis were evaluated. METHODS: Scopus, PubMed, Embase, Cochrane, Web of science databases, and Google Scholar and manual screening of retrieved references were systematically searched from their inception dates to 24 March 2020 by extracting the effect size (Odds ratios (OR) and relative risk (RR) in each study...
2023: International Journal of Preventive Medicine
#30
JOURNAL ARTICLE
Jacqueline E Rudolph, Keri Calkins, Xiaoqiang Xu, Eryka Wentz, Filip Pirsl, Kala Visvanathan, Bryan Lau, Corinne Joshu
BACKGROUND: Life expectancy among people with HIV (PWH) is increasing, making chronic conditions-including cancer-increasingly relevant. Among PWH, cancer burden has shifted from AIDS-defining cancers (ADCs) toward non-AIDS-defining cancers (NADCs). SETTING: We described incidence of cancer in a claims-based cohort of Medicaid beneficiaries. We included 43,426,043 Medicaid beneficiaries (180,058 with HIV) from 14 US states, aged 18-64, with >6 months of enrollment (with no dual enrollment in another insurance) and no evidence of a prior cancer...
October 9, 2023: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#31
JOURNAL ARTICLE
Chenyu Wang, Xianglai Jiang, Qiqi Zhao, Zhiyuan Xie, Hui Cai
Previous studies have determined that aberrant expression of the fas-associated death domain (FADD) contributes to the development of cancer. However, no pan-cancer analysis has been reported to explore the relationship between FADD and various cancers. Multiple databases were screened to identify cancer datasets for the present study and to validate the expression of FADD in various tumors. The association of FADD alteration with cancer prognosis, clinical features and tumor immunity was also evaluated. Reverse transcription-quantitative PCR (RT-qPCR) was utilized to confirm the expression of FADD in breast, colon, liver and gastric cancer cells...
November 2023: Biomedical Reports
#32
JOURNAL ARTICLE
S Y Zhang, J J Ruan, D M Jin, N Chen, W G Xie, Q F Ruan
Objective: To explore the biological role and clinical significance of ubiquitin-specific protease 7 (USP7) in the carcinogenesis of scar ulcer. Methods: A retrospective observational study combined with bioinformatics analysis was used. The RNA expression profile data of USP7 in tumor and/or its corresponding paracancular normal tissue were obtained from The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus database, and the RNA sequencing data were transformed by log2 . The variations of USP7 gene were analyzed by cBioPortal database...
June 20, 2023: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
#33
JOURNAL ARTICLE
C L Eccles, M Dubec, D Cobben, M van Herk, L McDaid, C Nelder, L Whiteside, L S C Davies, L McHugh, J Bridge, P Fendallamaro, R Chuter, P Hoskin, R A Huddart, A Choudhury
PURPOSE/OBJECTIVE(S): A 4-stage non-comparative prospective feasibility study to assess and develop imaging protocols for MRIgRT was opened at the first two centers using MR Linac technology in the UK. The primary aims of this study were to determine a) the acceptability of MR images for target and organ at risk delineation and registration; b) inter/intra observer registration and delineation variation. This work reports on the initial results from a single center. MATERIALS/METHODS: In June 2019, following ethical and regulatory approvals the 2nd UK centre began study recruitment as follows: Stage A: non-patient volunteer imaging to determine sequence suitability for normal tissue in 6 anatomical sites (head & neck (H&N), chest wall/breast, lung/esophagus, abdomen, male and female pelvis)...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#34
JOURNAL ARTICLE
N Gravbrot, R Hutten, S Lloyd, G Suneja, S B Johnson
PURPOSE/OBJECTIVE(S): For several cancers, delays between diagnosis and initiation of treatment has important clinical implications, often affecting trial eligibility, treatment intention, and oncologic outcomes. The coronavirus disease-19 (COVID-19) pandemic placed an extraordinary strain on the United States healthcare system, and its effect on oncologic patterns of care has yet to be established. We hypothesize that patients who received a new cancer diagnosis and subsequently tested positive for COVID-19 had delayed oncologic treatment compared to those who did not test positive for COVID-19...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#35
JOURNAL ARTICLE
G Rangaswamy, J Nicholson, N Wallace, E Connolly, O Houlihan, O Monaghan, J Trousdell, C Skourou, C Rohan, D Foley, F K Duane, B D O'Neill, P Thirion, M Cunningham, S M Brennan, O McArdle
PURPOSE/OBJECTIVE(S): Contouring tumor volumes and organs at risk is a key component of Radiation Oncology specialist training. As trainees rotate through different tumor sites, they are expected to develop proficiency in contouring skills relevant to their year of training. These skills have historically been acquired in an unstructured manner during supervised clinical work. However, trainees often struggle to learn these skills due to variability in practice and approach amongst senior colleagues...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#36
JOURNAL ARTICLE
P Riviere, K M Morgan, L N Deshler, X Huang, C Marienfeld, C Coyne, B S Rose, J D Murphy
PURPOSE/OBJECTIVE(S): Non-cancer patients prescribed chronic courses of opioids are at high risk of psychiatric or drug overdose particularly during the post-tapering period, but data are limited on this effect in cancer survivors. This study quantified emergency room visits or hospital admissions for psychiatric or drug/alcohol overdose/withdrawal (henceforth "events") in cancer survivors prescribed opioids related to their cancer diagnoses. MATERIALS/METHODS: We identified 15,002 cancer survivors in SEER-Medicare diagnosed between 2010 and 2017 with bladder, breast, colon/rectal, kidney, lung, head/neck, or prostate cancer who were prescribed at least 6 months of stable opioids following their cancer diagnosis...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#37
JOURNAL ARTICLE
Z H Li, T Kong, E M Dunne, M Liu, J S Chang, T W Zhang, M Chan, R McDermott
PURPOSE/OBJECTIVE(S): Higher biological equivalent doses of radiotherapy (RT) can improve symptom palliation and local control in select tumor sites. However, not all patients meet criteria for treatment with stereotactic ablative radiotherapy (SABR). Furthermore, SABR is a resource intensive technique which may limit its use in many centers. The 30 Gray in 5 fractions regimen (30/5) stems from a modification of 5-fraction SABR regimens. It is a conformal, homogenous hypo-fractionated regimen that delivers higher dose than conventional palliative RT while still respecting the normal tissue constraints for 5-fraction SABR...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#38
JOURNAL ARTICLE
K Murofushi, S Kuribayashi, K Ohnishi, S Hayakawa, K Tsuchida, Y Inoue, A Ohkawa, T Ishida, Y Machitori, K Nakai, D Takizawa
PURPOSE/OBJECTIVE(S): Vulnerable patients receive a low-intensity, palliative treatment rather than the standard treatment. Defining vulnerability in terms of standard or reduced radiation intensity can result in appropriate radiotherapy for elderly cancer patients without excessive adverse events and poor outcomes. However, it is difficult to define vulnerability, because radiation oncologists hesitate to include vulnerable patients in clinical trials involving radical radiotherapy. We hypothesized that for elderly cancer patients without metastasis, vulnerability scores, obtained by geriatric assessment (GA), could help in predicting the reduction in radiation intensity determined by radiation oncologists based on their experience...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#39
JOURNAL ARTICLE
Eric Zomawia, Zothan Zami, Andrew Vanlallawma, Nachimuthu Senthil Kumar, John Zothanzama, Lalchhanhimi Tlau, Lalchhandama Chhakchhuak, Lalawmpuii Pachuau, Jeremy L Pautu, Evelyn V L Hmangaihzuali
BACKGROUND: Despite being the second least populated state, Mizoram exhibits the highest incidence rate of cancer in India. Its inhabitants, constituting an endogamous and isolated population, have embraced their own distinct culture, way of life and dietary preferences, setting them apart from the rest of mainland India. In 2003, the Mizoram Population Based Cancer Registry (PBCR) was established under the auspices of the National Centre for Disease Informatics and Research (NCDIR), a division of the Indian Council of Medical Research (ICMR), in collaboration with the Department of Health & Family Welfare of the Government of Mizoram, India...
October 2023: Lancet Reg Health Southeast Asia
#40
REVIEW
Recent Studies in Photodynamic Therapy for Cancer Treatment: From Basic Research to Clinical Trials.
Tae Eun Kim, Ji-Eun Chang
Photodynamic therapy (PDT) is an emerging and less invasive treatment modality for various types of cancer. This review provides an overview of recent trends in PDT research, ranging from basic research to ongoing clinical trials, focusing on different cancer types. Lung cancer, head and neck cancer, non-melanoma skin cancer, prostate cancer, and breast cancer are discussed in this context. In lung cancer, porfimer sodium, chlorin e6, and verteporfin have shown promising results in preclinical studies and clinical trials...
August 31, 2023: Pharmaceutics
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