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https://www.readbyqxmd.com/read/27922659/eye-movement-analysis-and-cognitive-assessment-the-use-of-comparative-visual-search-tasks-in-a-non-immersive-vr-application
#1
Pedro J Rosa, Pedro Gamito, Jorge Oliveira, Diogo Morais, Matthew Pavlovic, Olivia Smyth, Inês Maia, Tiago Gomes
BACKGROUND: An adequate behavioral response depends on attentional and mnesic processes. When these basic cognitive functions are impaired, the use of non-immersive Virtual Reality Applications (VRAs) can be a reliable technique for assessing the level of impairment. However, most non-immersive VRAs use indirect measures to make inferences about visual attention and mnesic processes (e.g., time to task completion, error rate). OBJECTIVES: To examine whether the eye movement analysis through eye tracking (ET) can be a reliable method to probe more effectively where and how attention is deployed and how it is linked with visual working memory during comparative visual search tasks (CVSTs) in non-immersive VRAs...
December 6, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27921357/interrelationship-between-mini-mental-state-examination-scores-and-biochemical-parameters-in-patients-with-mild-cognitive-impairment-and-alzheimer-s-disease
#2
Ramasamy Vasantharekha, Hannah P Priyanka, Thangavel Swarnalingam, Avathvadi Venkatesan Srinivasan, Srinivasan ThyagaRajan
AIM: The aim of the present study was to provide first-hand information about the prevalence of mild cognitive impairment (MCI) and Alzheimer's disease (AD) in Tamil Nadu, a southern state in India, and examine if there exists a relationship between cognitive functions and biochemical parameters in these patients. METHODS: Surveys were collected from adults, older men and women (n = 3126) from different regions of Tamil Nadu, which were followed up after 12 months for 1337 participants...
December 6, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27920792/hippocampal-volumetry-as-a-biomarker-for-dementia-in-people-with-low-education
#3
Jaime D Mondragón, César Celada-Borja, Fernando Barinagarrementeria-Aldatz, Martín Burgos-Jaramillo, Héctor Manuel Barragán-Campos
BACKGROUND/AIMS: To evaluate the relationship between hippocampal volume and cognitive decline in patients with dementia due to probable Alzheimer's disease (AD), amnestic mild cognitive impairment (aMCI) and education, and the possible relationship between cognitive reserve and education in this population. METHODS: From February 2013 to October 2015, 76 patients (25 men, 51 women) were classified according to the NIA-AA diagnostic criteria. We used two 3.0-tesla MRI scanners and performed manual hippocampal volumetry...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/27913743/effect-of-dexmedetomidine-on-postoperative-cognitive-dysfunction-in-elderly-patients-after-general-anaesthesia-a-meta-analysis
#4
Chengmao Zhou, Yu Zhu, Zhen Liu, Lin Ruan
OBJECTIVE: We undertook a meta-analysis to investigate the effect of dexmedetomidine on postoperative cognitive dysfunction (POCD). METHODS: We searched PubMed, EMBASE, the Cochrane Library, CNKI and Google Scholar to find randomized controlled trials (RCTs) of the influence of dexmedetomidine on POCD in elderly adults who had undergone general anaesthesia. Two researchers independently screened the literature, extracted data, and evaluated methodologic quality against inclusion and exclusion criteria...
December 2, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27911323/short-term-response-is-not-predictive-of%C3%A2-long-term-response-to%C3%A2-acetylcholinesterase-inhibitors-in-old-age-subjects-with-alzheimer-s-disease-a%C3%A2-real-world-study
#5
Virginia Boccardi, Marta Baroni, Nicoletta Smirne, Alessandra Clodomiro, Sara Ercolani, Annalisa Longo, Carmelinda Ruggiero, Amalia C Bruni, Patrizia Mecocci
BACKGROUND: Most of clinical guidelines recommend discontinuing treatment with cholinesterase inhibitors (ChEIs) in patients with Alzheimer's disease (AD) who do not show an initial response to therapy as evaluated with the Mini-Mental State Examination (MMSE) scale. However, understanding the relationship between the initial response to ChEI treatment and the subsequent course of the disease is extremely important in clinical practice, but evidence is limited, particularly in the old-old population...
November 29, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911296/screening-for-mild-cognitive-impairment-and-dementia-with-automated-anonymous-online-and-telephone-cognitive-self-tests
#6
Lisa D Van Mierlo, Hans Wouters, Sietske A M Sikkes, Wiesje M Van der Flier, Niels D Prins, Jonne A E Bremer, Teddy Koene, Hein P J Van Hout
BACKGROUND: Many older people worry about cognitive decline. Early cognitive screening in an anonymous and easily accessible manner may reassure older people who are unnecessarily worried about normal cognitive aging while it may also expedite help seeking in case of suspicious cognitive decline. OBJECTIVE: To develop and validate online and telephone-based automated self-tests of cognitive function. METHODS: We examined the feasibility and validity of the self-tests in a prospective study of 117 participants of whom 34 had subjective cognitive decline (SCD), 30 had mild cognitive impairment (MCI), and 53 had dementia...
November 29, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911294/deleterious-effect-of-butyrylcholinesterase-k-variant-in-donepezil-treatment-of-mild-cognitive-impairment
#7
Sophie Sokolow, Xiaohui Li, Lucia Chen, Kent D Taylor, Jerome I Rotter, Robert A Rissman, Paul S Aisen, Liana G Apostolova
BACKGROUND: Donepezil is an acetylcholinesterase inhibitor frequently prescribed for the treatment of mild cognitive impairment (MCI) though not approved by the Food and Drug Administration for this indication. In Alzheimer's disease, butyrylcholinesterase (BChE) activity increases with disease progression and may replace acetylcholinesterase function. The most frequent polymorphism of BChE is the K-variant, which is associated with lower acetylcholine-hydrolyzing activity. BChE-K polymorphism has been studied in Alzheimer's disease progression and donepezil therapy, and has led to contradictory results...
November 29, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27909150/validity-of-the-georgian-montreal-cognitive-assessment-for-the-screening-of-mild-cognitive-impairment-and-dementia
#8
Marina Janelidze, Nina Mikeladze, Nazibrola Bochorishvili, Ann Dzagnidze, Mariam Kapianidze, Nino Mikava, Irene Khatiashvili, Darejan Kakhiani, Ekaterina Mirvelashvili, Nino Shiukashvili, Zurab Nadareishvili
Montreal Cognitive Assessment (MoCA) test has been shown to be a reliable tool to detect mild cognitive impairment (MCI), however, no Georgian language version exists. The goal of this study is to determine the validity, reliability, and accuracy of Georgian version of MoCA in the evaluation of amnestic MCI (aMCI) and Alzheimer's disease (AD). Montreal Cognitive Assessment was translated into Georgian language and was administered to healthy participants (HP) and patients with aMCI and AD. We studied 46 HS, 20 patients with aMCI, and 20 patients with AD...
November 30, 2016: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27905386/-cognitive-impairment-in-patients-poluchennym-ischemic-stroke-in-the-acute-and-early-recovery-periods-in-the-process-of-neuroprotection-low-dose-drug-cortexin
#9
L A Belova, V V Mashin, V V Abramova, A N Proshin, A N Ovsyannikova
AIM: To study the effect of repeated low-dose course of neuroprotection by drug cortexin on cognitive impairment in the acute and early recovery periods of hemispheric ischemic stroke. MATERIAL AND METHODS: The study involved 90 patients with poluchennym ischemic stroke. Patients of the first group received cortexin 20 mg (10+10) intramuscularly on the background of basic therapy, patients of the second group (n=30) received cortexin 20 mg (10+10) two courses for 10 days each with a break in between of 10 days, the patients of the third group - only basic therapy...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27905357/-screening-of-cognitive-impairment-in-the-old-and-old-old-population-with-the-3-ct-scale
#10
D A Gutorova, E E Vasenina, O S Levin
AIM: To determine sensitivity and specificity of the 3-CT scale, a combination of 3 simple and minimum cost tests, for screening purposes in old and old-old patients in comparison to the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). MATERIAL AND METHODS: The study included 106 patients. Assessment of sensitivity and specificity of neuropsychological testing with ROC-curves was used. RESULTS: MoCA showed moderate sensitivity (0...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27904618/assessment-of-different-anesthesia-depth-under-total-intravenous-anesthesia-on-postoperative-cognitive-function-in-laparoscopic-patients
#11
Delin Zhang, Aiqing Nie
BACKGROUND: This study aimed to compare the effects of different depths of sedation during total intravenous anesthesia (TIVA) with remifentanil and propofol given by target-controlled infusion (TCI) on postoperative cognitive function in young and middle-aged patients undergoing gynecological laparoscopic surgery. MATERIALS AND METHODS: A total of 150 American Society of Anesthesiologists physical Status I/II patients scheduled for gynecological laparoscopic operation were randomly divided into three groups...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903307/the-cumulative-effect-of-frailty-and-cognition-on-mortality-results-of-a-prospective-cohort-study
#12
Philip D St John, Suzanne L Tyas, Lauren E Griffith, Verena Menec
BACKGROUND: Both physical frailty and cognitive impairment predict death, but the joint effect of these two factors is uncertain. The objectives are to determine if the Mini-mental state examination (MMSE) and the Frailty Index (FI) predict death over a five-year interval after accounting for the effect of the other; and if there is an interaction in this effect. METHODS: An analysis of an existing prospective cohort study of 1,751 community living older adults followed over a five-year time frame...
December 1, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27903242/reliability-and-construct-validity-of-the-early-dementia-questionnaire-edq
#13
Zurraini Arabi, Syed Alwi Syed Abdul Rahman, Helmy Hazmi, Nazeefah Hamdin
BACKGROUND: Early Dementia Questionnaire (EDQ) was developed as a screening tool to detect patients with early dementia in primary care. It was developed based on 20 symptoms of dementia. From a preliminary study, EDQ had been shown to be a promising alternative for screening of early dementia. This study was done to further test on EDQ's reliability and validity. METHODS: Using a systematic random sampling, 200 elderly patients attending primary health care centers in Kuching, Sarawak had consented to participate in the study and were administered the EDQ...
November 30, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27902677/perception-of-fechner-illusory-colors-in-alzheimer-disease-patients
#14
Gintaras Kaubrys, Vera Bukina, Ieva Bingelytė, Vladas Taluntis
BACKGROUND Alzheimer disease (AD) primarily affects cognition. A variety of visual disorders was established in AD. Fechner illusory colors are produced by a rotating disk with a black and white pattern. The purpose of our research was to explore the perception of illusory colors in AD. MATERIAL AND METHODS W recruited 40 AD patients (MMSE ≥14) and 40 normal controls (CG group) matched by age, education, gender in this prospective, cross-sectional, case-control study. An achromatic Benham's disk attached to a device to control the speed and direction of rotation was used to produce illusory colors...
November 30, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27902618/cumulative-systolic-blood-pressure-exposure-in-relation-to-cognitive-function-in-middle-aged-and-elderly-adults-a-prospective-population-based-study
#15
Jie Liu, Yuling Huang, Guojuan Chen, Xiaoxue Liu, Zhijun Wang, Yibin Cao, Haitao Li, Lu Song, Chunhui Li, Hualing Zhao, Shuohua Chen, Yiming Wang, Ruiying Zhang, Anxin Wang, Shouling Wu
The association between systolic blood pressure (SBP) and cognitive function is controversial in elderly adults. In addition, few studies focused on the cumulative effect of SBP. We aimed to investigate the association between cumulative SBP exposure and cognitive function among middle-aged and elderly adults.The analysis was based on the Asymptomatic Polyvascular Abnormalities Community (APAC) study. The primary predictor was the cumulative SBP calculated by consecutive SBP values measured through baseline (2006-2007) up to the fourth examination (2012-2013)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27901517/ideomotor-limb-apraxia-as-a-staging-tool-in-individuals-with-alzheimer-s-disease-iliad
#16
William D Soulsby, Nezar El-Ruwie, Shravan Gatla, Katelyn Anderson Zimmer, Safa Najmi, Alexander Chen, John T Chibnall, George T Grossberg
BACKGROUND: Ideomotor apraxia (IMA) is known to affect individuals with Alzheimer's disease (AD). Combined with impaired cognitive function, IMA can support evidence of probable AD. However, apraxia is a condition that is difficult to diagnose. The Postural Knowledge Test (PKT), developed by Mozaz et al, was designed to easily identify limb apraxia in multiple sclerosis yet demonstrated potential utility for AD. ILIAD is a pilot study to investigate correlation between the PKT and Mini-Mental State Examination (MMSE)...
November 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/27899478/one-year-prospective-study-on-the-presence-of-chronic-diseases-and-subsequent-cognitive-decline-in-older-adults
#17
Hamzah Bakouni, Samantha Gontijo Guerra, Veronica Chudzinski, Djamal Berbiche, Helen-Maria Vasiliadis
BACKGROUND: The literature is inconsistent regarding the effect of the presence of chronic physical and mental diseases on cognitive decline in older adults. The objectives of this study were to explore the effect of chronic diseases on subsequent cognitive decline assessed via the Mini Mental State Examination (MMSE) in community living older adults. METHODS: We used data from individuals (n = 2010) participating in the ESA (Étude sur la Santé des Aînés) study...
November 29, 2016: Journal of Public Health
https://www.readbyqxmd.com/read/27898735/cognitive-dysfunction-and-malnutrition-are-independent-predictor-of-dysphagia-in-patients-with-acute-exacerbation-of-congestive-heart-failure
#18
Junichi Yokota, Yoshiko Ogawa, Shinsuke Yamanaka, Yoshimi Takahashi, Hiroshi Fujita, Nobuhiro Yamaguchi, Noriko Onoue, Takeshi Ishizuka, Tsuyoshi Shinozaki, Masahiro Kohzuki
Early detection and intervention for dysphagia is important in patients with congestive heart failure (CHF). However, previous studies have focused on how many patients with dysphagia develop CHF. Studies focusing on the comorbidity of dysphagia in patients with CHF are rare. Additionally, risk factors for dysphagia in patients with CHF are unclear. Thus, the aim of this study was to clarify risk factors for dysphagia in patients with acute exacerbation of CHF. A total of 105 patients, who were admitted with acute exacerbation of CHF, were enrolled...
2016: PloS One
https://www.readbyqxmd.com/read/27894458/personality-and-global-cognitive-decline-in-japanese-community-dwelling-elderly-people-a-10-year-longitudinal-study
#19
Yukiko Nishita, Chikako Tange, Makiko Tomida, Rei Otsuka, Fujiko Ando, Hiroshi Shimokata
OBJECTIVES: To examine the longitudinal associations between the big five personality and changes in global cognitive function among community-dwelling elderly people involved in the National Institute for Longevity Sciences - Longitudinal Study of Aging. METHODS: The participants were 594 individuals (age range 60-81years) and followed for 10years and tested six times. Personality was assessed by the Japanese version of NEO five factor inventory at baseline. Cognitive function was assessed by the Japanese version of Mini Mental State Examination (MMSE) at all visits...
December 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27893859/hippocampal-calcification-on-computed-tomography-in-relation-to-cognitive-decline-in-memory-clinic-patients-a-case-control-study
#20
Remko Kockelkoren, Jill B De Vis, Willem P Th M Mali, Jeroen Hendrikse, Pim A de Jong, Annemieke M Rozemuller, Huiberdina L Koek
BACKGROUND: It was recently shown that calcification of the hippocampus can be detected on computed tomography (CT) images and these calcifications occur in up to 20% of people over 50 years of age. However, little is known about hippocampal calcification and its relation to cognition and cognitive decline. Therefore, the aim of this study was to (1) determine the prevalence of hippocampal calcification on CT in memory clinic patients controls, and (2) to assess its relation with cognitive decline...
2016: PloS One
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