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https://www.readbyqxmd.com/read/28926815/cognitive-function-and-walking-velocity-in-people-with-dementia-a-comparison-of-backward-and-forward-walking
#1
Hanna Johansson, Lillemor Lundin-Olsson, Håkan Littbrand, Yngve Gustafson, Erik Rosendahl, Annika Toots
How forward and backward walking, both central to everyday life, relate to cognition are relatively unexplored in people with dementia. This study aimed to investigate if forward and backward walking velocity respectively, associated with global cognition and executive function in people with dementia, and whether the association differed according to walking aid use or dementia type. Using a cross-sectional design, 161 participants (77% women), a mean Mini-Mental State Examination (MMSE) score of 15, and mean age of 85...
September 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28926416/blood-pressure-variability-and-cognitive-function-among-older-african-americans-introducing-a-new-blood-pressure-variability-measure
#2
Siny Tsang, Scott A Sperling, Moon Ho Park, Ira M Helenius, Ishan C Williams, Carol Manning
BACKGROUND: Although blood pressure (BP) variability has been reported to be associated with cognitive impairment, whether this relationship affects African Americans has been unclear. We sought correlations between systolic and diastolic BP variability and cognitive function in community-dwelling older African Americans, and introduced a new BP variability measure that can be applied to BP data collected in clinical practice. METHODS: We assessed cognitive function in 94 cognitively normal older African Americans using the Mini-Mental State Examination (MMSE) and the Computer Assessment of Mild Cognitive Impairment (CAMCI)...
September 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28924104/validation-of-the-r2chads2-and-chads2-scores-for-predicting-post-stroke-cognitive-impairment
#3
Kazuo Washida, Hisatomo Kowa, Hirotoshi Hamaguchi, Fumio Kanda, Tatsushi Toda
Objective Post-stroke cognitive impairment often afflicts stroke survivors and is a major obstacle both for cognitive and physical rehabilitation. Stroke risk scores ["Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, Stroke" (CHADS2) and "CHADS2 + creatinine clearance <60 mL/min" (R2CHADS2)] are used to assess the future risk of cardioembolic stroke in patients with atrial fibrillation (AF). However, congestive heart failure, hypertension, aging, diabetes mellitus, stroke, and renal dysfunction are also risk factors for cognitive impairment...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28922926/acupuncture-plus-herbal-medicine-for-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#4
Simin Zhou, Lanlan Dong, Yuan He, Hong Xiao
Alzheimer's disease (AD) is associated with the unprecedented aging tendency in our world population and has become a significant health issue. The use of Traditional Chinese Medicine to treat AD has been increasing in recent years. The objective of this meta-analysis is to evaluate the effectiveness of combining acupuncture with herbal medicine to treat AD. Randomized controlled trials (RCTs) of acupuncture plus herbals versus treatment with western drugs for AD were retrieved from 11 databases. The data were extracted by two authors; dichotomous data were expressed as odds ratio (ORs) and 95% confidence intervals (CIs), while continuous data were calculated by mean differences (MDs) with 95% CIs...
September 18, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28919856/visualizing-hyperactivation-in-neurodegeneration-based-on-prefrontal-oxygenation-a-comparative-study-of-mild-alzheimer-s-disease-mild-cognitive-impairment-and-healthy-controls
#5
Kah Hui Yap, Wei Chun Ung, Esther G M Ebenezer, Nadira Nordin, Pui See Chin, Sandheep Sugathan, Sook Ching Chan, Hung Loong Yip, Masashi Kiguchi, Tong Boon Tang
Background: Cognitive performance is relatively well preserved during early cognitive impairment owing to compensatory mechanisms. Methods: We explored functional near-infrared spectroscopy (fNIRS) alongside a semantic verbal fluency task (SVFT) to investigate any compensation exhibited by the prefrontal cortex (PFC) in Mild Cognitive Impairment (MCI) and mild Alzheimer's disease (AD). In addition, a group of healthy controls (HC) was studied. A total of 61 volunteers (31 HC, 12 patients with MCI and 18 patients with mild AD) took part in the present study...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28912299/the-test-your-memory-for-mild-cognitive-impairment-tym-mci
#6
Jeremy M Brown, Claire J Lansdall, Julie Wiggins, Kate E Dawson, Kristina Hunter, James B Rowe, Richard A Parker
BACKGROUND: To validate a short cognitive test: the Test Your Memory for Mild Cognitive Impairment (TYM-MCI) in the diagnosis of patients with amnestic mild cognitive impairment or mild Alzheimer's disease (aMCI/AD). METHODS: Two hundred and two patients with mild memory problems were recruited. All had 'passed' the Mini-Mental State Examination (MMSE). Patients completed the TYM-MCI, the Test Your Memory test (TYM), MMSE and revised Addenbrooke's Cognitive Examination (ACE-R), had a neurological examination, clinical diagnostics and multidisciplinary team review...
September 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28894898/effective-collateral-circulation-may-indicate-improved-perfusion-territory-restoration-after-carotid-endarterectomy
#7
Tianye Lin, Zhichao Lai, Yuelei Lv, Jianxun Qu, Zhentao Zuo, Hui You, Bing Wu, Bo Hou, Changwei Liu, Feng Feng
OBJECTIVES: To investigate the relationship between the level of collateral circulation and perfusion territory normalisation after carotid endarterectomy (CEA). METHODS: This study enrolled 22 patients with severe carotid stenosis that underwent CEA and 54 volunteers without significant carotid stenosis. All patients were scanned with ASL and t-ASL within 1 month before and 1 week after CEA. Collateral circulation was assessed on preoperative ASL images based on the presence of ATA...
September 11, 2017: European Radiology
https://www.readbyqxmd.com/read/28894825/hearing-loss-as-a-risk-factor-for-dementia-a-systematic-review
#8
REVIEW
Rhett S Thomson, Priscilla Auduong, Alexander T Miller, Richard K Gurgel
OBJECTIVES: To review evidence of hearing loss as a risk factor for dementia. Data Sources: PubMed Review methods: A systematic review was conducted using the PubMed database using the search terms (hearing loss OR presbycusis) AND (dementia OR cognitive decline). Initially, 488 articles were obtained. Only those studies evaluating an association between hearing loss and incident dementia or cognitive decline were included in the analysis. This resulted in 17 articles which were thoroughly evaluated with consideration for study design, method for determining hearing loss and cognitive status, relevant covariates and confounding factors, and key findings...
April 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28894304/quantification-of-brain-cholinergic-denervation-in-alzheimer-s-disease-using-pet-imaging-with-18-f-feobv
#9
M Aghourian, C Legault-Denis, J-P Soucy, P Rosa-Neto, S Gauthier, A Kostikov, P Gravel, M-A Bédard
(18)F-fluoroethoxybenzovesamicol (FEOBV) is a new PET radiotracer that binds to the vesicular acetylcholine transporter. In both animals and healthy humans, FEOBV was found sensitive and reliable to characterize presynaptic cholinergic nerve terminals in the brain. It has been used here for we believe the first time in patients with Alzheimer's disease (AD) to quantify brain cholinergic losses. The sample included 12 participants evenly divided in healthy subjects and patients with AD, all assessed with the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) cognitive scales...
September 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28893185/factors-that-influence-the-levels-of-cerebrospinal-fluid-biomarkers-in-memory-clinic-patients
#10
Anne-Brita Knapskog, Rannveig Sakshaug Eldholm, Anne Braekhus, Knut Engedal, Ingvild Saltvedt
BACKGROUND: The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ), phospho tau (P-tau) and total tau (T-tau) are used increasingly to support a clinical diagnosis of Alzheimer's disease. The diagnostic power of these biomarkers has been reported to vary among different studies' results. The results are poorer when heterogeneous groups of patients have been included compared to studies where patients with Alzheimer's dementia (AD) and healthy controls have been studied. The aim of this study was to examine if age, APOE genotype and sex were associated with the levels of CSF biomarkers among patients referred to a memory clinic...
September 11, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28888555/functional-impairment-prior-to-major-non-cardiac-surgery-is-associated-with-mortality-within-one-year-in-elderly-patients-with-gastrointestinal-gynaecological-and-urogenital-cancer-a-prospective-observational-cohort-study
#11
Maren Schmidt, Rahel Eckardt, Sarah Altmeppen, Klaus-Dieter Wernecke, Claudia Spies
OBJECTIVE: To investigate the prognostic value of elements of the Geriatric Assessment, in particular the Timed Up and Go (TUG) Test and the Barthel Index of Activities of Daily Living (ADL) for one-year post-operative mortality in elderly patients with cancer. MATERIALS AND METHODS: This prospective cohort study included patients 65years of age or older undergoing elective major surgery for cancer between June 2008 and June 2010. Preoperative functional status was measured by the TUG Test and the Barthel Index of ADL Cognitive state was assessed by the Mini Mental State Examination (MMSE)...
September 6, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28888073/selective-decline-of-neurotrophin-and-neurotrophin-receptor-genes-within-ca1-pyramidal-neurons-and-hippocampus-proper-correlation-with-cognitive-performance-and-neuropathology-in-mild-cognitive-impairment-and-alzheimer-s-disease
#12
Stephen D Ginsberg, Michael H Malek-Ahmadi, Melissa J Alldred, Shaoli Che, Irina Elarova, Yinghua Chen, Freddy Jeanneteau, Thorsten M Kranz, Moses V Chao, Scott E Counts, Elliott J Mufson
Hippocampal CA1 pyramidal neurons, a major component of the medial temporal lobe memory circuit, are selectively vulnerable during the progression of Alzheimer's disease (AD). The cellular mechanism(s) underlying degeneration of these neurons and the relationship to cognitive performance remains largely undefined. Here, we profiled neurotrophin and neurotrophin receptor gene expression within microdissected CA1 neurons along with regional hippocampal dissections from subjects who died with a clinical diagnosis of no cognitive impairment (NCI), mild cognitive impairment (MCI), or AD using laser capture microdissection (LCM), custom-designed microarray analysis, and qPCR of CA1 subregional dissections...
September 9, 2017: Hippocampus
https://www.readbyqxmd.com/read/28887373/optical-coherence-tomography-identifies-outer-retina-thinning-in-frontotemporal-degeneration
#13
Benjamin J Kim, David J Irwin, Delu Song, Ebenezer Daniel, Jennifer D Leveque, Aaishah R Raquib, Wei Pan, Gui-Shuang Ying, Tomas S Aleman, Joshua L Dunaief, Murray Grossman
OBJECTIVE: Whereas Alzheimer disease (AD) is associated with inner retina thinning visualized by spectral-domain optical coherence tomography (SD-OCT), we sought to determine if the retina has a distinguishing biomarker for frontotemporal degeneration (FTD). METHODS: Using a cross-sectional design, we examined retinal structure in 38 consecutively enrolled patients with FTD and 44 controls using a standard SD-OCT protocol. Retinal layers were segmented with the Iowa Reference Algorithm...
September 8, 2017: Neurology
https://www.readbyqxmd.com/read/28886705/cognitive-function-in-very-old-men-does-not-correlate-to-biomarkers-of-alzheimer-s-disease
#14
V Velickaite, V Giedraitis, K Ström, I Alafuzoff, H Zetterberg, L Lannfelt, L Kilander, E-M Larsson, M Ingelsson
BACKGROUND: The Alzheimer's disease (AD) brain displays atrophy with amyloid-β (Aβ) and tau deposition, whereas decreased Aβ42 and increased tau are measured in cerebrospinal fluid (CSF). The aim of this study was to relate cognitive performance to the degree of brain atrophy, CSF biomarker levels and neuropathology in a cohort of aged men. METHODS: Fifty-eight 86-92-year-old men from the Uppsala Longitudinal Study of Adult Men (ULSAM) cohort underwent cognitive testing, brain computed tomography and lumbar puncture...
September 8, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28884714/-therapeutic-monitoring-and-prediction-of-the-efficacy-of-neurotrophic-treatment-in-patients-with-amnestic-type-of-mild-cognitive-impairment
#15
S I Gavrilova, O M Volpina, I V Kolykhalov, Ya B Fedorova, N D Selezneva, E V Ponomareva, D O Koroev, A V Kamynina
AIM: To perform therapeutic monitoring and prediction of the neurotrophic therapy efficacy in patients with amnestic type of mild cognitive impairment (aMCI) in a model of course cerebrolysin therapy. MATERIAL AND METHODS: The study involved a group of 19 elderly patients who met the diagnostic criteria of aMCI. All patients received a course of neurotrophic therapy consisting of 20 intravenous infusions of cerebrolysin (30 ml of cerebrolysin in 100 ml of isotonic sodium chloride solution)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28884566/effects-on-cognitive-function-of-propofol-medium-and-long-chain-lipid-emulsion-in-patients-with-hepatic-encephalopathy
#16
Shenghui Yu, Jianlei Hu, Li Ding, Da Yu
BACKGROUND: Our study aimed to investigate the effects of propofol medium and long chain lipid emulsion on cognitive function of the patients with hepatic encephalopathy undergoing hemofiltration treatment. METHODS: A total of 87 patients diagnosed with hepatic encephalopathy from January 2014 to January 2016 were continuously selected, and randomly (Using Random number method) divided into an observation group (45 cases) and a control group (42 cases). All patients were treated with persistent hemofiltration; the patients in control group were not given any sedative measures, while the patients in observation group were given a propofol medium-long chain lipid emulsion injection with a dose determined by each individual's degree of restlessness and tolerance to hemofiltration (Intravenous injection was performed with the first dose of 100mg, and then patients are subjected to micro-infusion pump with a dose of 0...
September 7, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28883859/neuropsychiatric-symptoms-and-faster-progression-of-cognitive-impairments-as-predictors-of-risk-of-conversion-of-mild-cognitive-impairment-to-dementia
#17
Mariola Bidzan, Leszek Bidzan, Ilona Bidzan-Bluma
INTRODUCTION: The aim of this research, based on 7 years of observations, was to assess the relationship between the dynamics of changes in the realm of cognitive functions in the early stages of observations and the presence of neuropsychiatric symptoms as well as further progression of cognitive function impairments in people diagnosed with mild cognitive impairment (MCI). MATERIAL AND METHODS: One hundred and ninety three individuals were included in the study, all of whom referred themselves to the Mental Health Clinic and were diagnosed with MCI based on the criteria of the Working Group on MCI...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28883858/association-between-low-thyroid-stimulating-hormone-posterior-cortical-atrophy-and-nitro-oxidative-stress-in-elderly-patients-with-cognitive-dysfunction
#18
Adriana E Bulboacă, Sorana D Bolboacă, Angelo C Bulboacă, Călin I Prodan
INTRODUCTION: Cortical atrophy is known to be a valuable sign of cognitive decline. The purpose of this study was to assess the association between low thyroid-stimulating hormone (TSH), posterior cortical atrophy (Koedam score - KS) and nitro-oxidative stress in elderly patients. MATERIAL AND METHODS: A study (SG) and a control group (CG), each subdivided by gender, were investigated. Subjects older than 59 years with low serum TSH level and with mild cognitive impairment were included in the SG...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28881062/the-brief-memory-and-executive-test-bmet-a-cognitive-screening-tool-to-detect-and-differentiate-vascular-cognitive-impairment-and-alzheimer-s-disease
#19
Matthew J Hollocks, Rebecca L Brookes, Robin G Morris, Hugh S Markus
OBJECTIVE: While there are several cognitive screening tests available for the detection of cortical dementias such as Alzheimer's disease (AD), these are rarely designed to be sensitive to vascular cognitive impairment (VCI). The Brief Memory and Executive Test (BMET) is a screening measure designed to be sensitive to the cognitive profile of both VCI and AD. This study investigated the ability of the BMET to detect AD, and to differentiate between VCI and AD. METHODS: This study included 150 patients, with either SVD, both with (n = 48) and without VCI (n = 51), or AD (N = 51) and 51 healthy controls...
September 7, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28875464/changes-in-tryptophan-catabolite-trycat-pathway-patterning-are-associated-with-mild-impairments-in-declarative-memory-in-schizophrenia-and-deficits-in-semantic-and-episodic-memory-coupled-with-increased-false-memory-creation-in-deficit-schizophrenia
#20
Buranee Kanchanatawan, Solaphat Hemrungrojn, Supaksorn Thika, Sunee Sirivichayakul, Kiat Ruxrungtham, André F Carvalho, Michel Geffard, George Anderson, Michael Maes
Evidence indicates that schizophrenia and in particular negative symptoms and deficit schizophrenia are accompanied by neurocognitive impairments and changes in the patterning of the tryptophan catabolite (TRYCAT) pathway. This cross-sectional study was carried out to examine the associations between cognitive functions (as measured with Consortium to Establish a Registry for Alzheimer's disease (CERAD)) and TRYCAT pathway patterning in patients with (n = 40) and without (n = 40) deficit schizophrenia and normal controls (n = 40)...
September 5, 2017: Molecular Neurobiology
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