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https://www.readbyqxmd.com/read/28734235/characterization-of-cognitive-performance-and-evaluation-of-quality-of-life-among-patients-with-htlv-1
#1
Liliana Raulino Goncalves, Leopoldo Nelson Fernandes Barbosa, Paula Machado Ribeiro Magalhaes, Pedro Augusto Sampaio Rocha-Filho
OBJECTIVE: To characterize cognitive alterations among patients with HTLV-1, ascertain what is associated with these alterations and evaluate these patients' quality of life. PATIENTS AND METHODS: This was a cross-sectional study. Patients infected by HTLV-1 who were seen at the Oswaldo Cruz University Hospital from March 2014 to June 2015 were included in the study. A semi-structured questionnaire and the Mini-Mental State Examination, Color Trails Test, Wechsler Adult Intelligence Scale (WAIS-III), Hospital Anxiety and Depression Scale and Medical Outcomes Study 36-Item Short-Form Health Survey (SF36) were used...
July 12, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28729939/feature-selective-temporal-prediction-of-alzheimer-s-disease-progression-using-hippocampus-surface-morphometry
#2
Sinchai Tsao, Niharika Gajawelli, Jiayu Zhou, Jie Shi, Jieping Ye, Yalin Wang, Natasha Leporé
INTRODUCTION: Prediction of Alzheimer's disease (AD) progression based on baseline measures allows us to understand disease progression and has implications in decisions concerning treatment strategy. To this end, we combine a predictive multi-task machine learning method (cFSGL) with a novel MR-based multivariate morphometric surface map of the hippocampus (mTBM) to predict future cognitive scores of patients. METHODS: Previous work has shown that a multi-task learning framework that performs prediction of all future time points simultaneously (cFSGL) can be used to encode both sparsity as well as temporal smoothness...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28729834/white-matter-hyperintensity-in-elderly-patients-with-diabetes-mellitus-is-associated-with-cognitive-impairment-functional-disability-and-a-high-glycoalbumin-glycohemoglobin-ratio
#3
Yoshiaki Tamura, Yoshiyuki Kimbara, Takuya Yamaoka, Ken Sato, Yuki Tsuboi, Remi Kodera, Yuko Chiba, Seijiro Mori, Yoshinori Fujiwara, Aya M Tokumaru, Hideki Ito, Takashi Sakurai, Atsushi Araki
Aims: Although evidence has accumulated that white matter hyperintensity (WMH) is associated with the deterioration of cognitive function and impairment of activities of daily living (ADL), the clinical relevance of WMH in elderly patients with diabetes mellitus (DM) is not still clear. The aim of this study was to examine whether WMH volume is associated with ADL and cognitive function and whether glucose control and glucose variability can affect WMH volume in these patients. Methods: This cross-sectional study investigated the associations of WMH with cognitive function and instrumental ADL (IADL), as well as metabolic and vascular risk factors in a total of 178 elderly patients with diabetes...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28726034/mentally-stimulating-activities-associate-with-better-cognitive-performance-in-parkinson-disease
#4
Jeffrey L B Bohnen, Martijn L T M Müller, Jacob Haugen, Nicolaas I Bohnen
Subjects at risk of dementia benefit from participation in mentally stimulating activities, but no prior studies have investigated similar associations in Parkinson disease (PD). The aim of this study was to investigate the relationship between times spent engaging in mentally stimulating activities and cognitive functions in PD while accounting for the degree of primary neurodegenerations. PD patients (N = 41, 33 males; age 68.5 ± 7.2; Hoehn and Yahr stage 2.6 ± 0.6) completed the Community Health Activities Model Program for Seniors questionnaire, mini-mental state examination (MMSE), and [(11)C]dihydrotetrabenazine dopaminergic and [(11)C]piperidinyl propionate acetylcholinesterase PET imaging...
July 19, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28716246/cognitive-impairment-predicts-worse-short-term-response-to-spinal-tap-test-in-normal-pressure-hydrocephalus
#5
Thomas Wolfsegger, Raffi Topakian
INTRODUCTION: In patients with idiopathic normal pressure hydrocephalus (iNPH), the spinal tap test (STT) is commonly used to predict ventriculoperitoneal shunt responsiveness. Clinical improvement following STT usually is measured by testing gait function. In our study, we investigated the impact of cognitive impairment on gait improvement after STT. METHODS: 22 patients with the clinical and radiological diagnosis of iNPH underwent gait analyses (mobile measuring system Medilogic) before and 2-4h after STT in self-paced gait velocity over 7m...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28715287/outcome-measures-correlated-with-falls-in-nursing-home-residents-a-pilot-study
#6
Heidi S Moyer, Jeffrey Gale, Stephen Severe, Heather J Braden, Scott Hasson
Most fall risk and normal values are collected from the community-dwelling population, which is not representative of nursing home residents. The purpose of this study was twofold: 1) to determine the relationship of clinical impairment and activity limitation variables to the number of falls in nursing home residents; and 2) to determine the amount of variability that can be explained for the number of falls from these predictor variables. Seventeen active nursing home residents (83.7 ± 11.7 years) consented to participate...
July 17, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28713690/three-dimensional-stereotactic-surface-projection-in-the-statistical-analysis-of-single-photon-emission-computed-tomography-data-for-distinguishing-between-alzheimer-s-disease-and-depression
#7
Eiji Kirino
AIM: To evaluate usefulness of single photon emission computed tomography (SPECT) with three-dimensional stereotactic surface projection (3D-SSP) in distinguishing between Alzheimer's disease (AD) and depression. METHODS: We studied 43 patients who presented with both depressive symptoms and memory disturbance. Each subject was evaluated using the following: (1) the Minimal Mental State Examination; (2) the Hamilton Rating Scale for Depression; (3) Clinical Global Impression-Severity scale (CGI-S); and (4) SPECT imaging with 3D-SSP...
June 22, 2017: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28713585/associations-of-centrally-acting-ace-inhibitors-with-cognitive-decline-and-survival-in-alzheimer-s-disease
#8
Karim Fazal, Gayan Perera, Mizanur Khondoker, Robert Howard, Robert Stewart
BACKGROUND: Cognitive improvement has been reported in patients receiving centrally acting angiotensin-converting enzyme inhibitors (C-ACEIs). AIMS: To compare cognitive decline and survival after diagnosis of Alzheimer's disease between people receiving C-ACEIs, non-centrally acting angiotensin-converting enzyme inhibitors (NC-ACEIs), and neither. METHOD: Routine Mini-Mental State Examination (MMSE) scores were extracted in 5260 patients receiving acetylcholinesterase inhibitors and analysed against C-/NC-ACEI exposure at the time of Alzheimer's disease diagnosis...
July 2017: BJPsych Open
https://www.readbyqxmd.com/read/28712841/long-term-impact-of-subthalamic-stimulation-on-cognitive-function-in-patients-with-advanced-parkinson-s-disease
#9
M Acera, A Molano, B Tijero, G Bilbao, I Lambarri, R Villoria, J Somme, E Ruiz de Gopegui, I Gabilondo, J C Gomez-Esteban
OBJECTIVE: The aim of this study was to evaluate the effects of deep brain stimulation of the subthalamic nucleus (DBS-SN) on cognitive function in patients with Parkinson's disease (PD) 5 years after surgery. MATERIAL AND METHODS: We conducted a prospective study including 50 patients with PD who underwent DBS-SN (62.5% were men; mean age of 62.2±8.2 years; mean progression time of 14.1±6.3 years). All patients were assessed before the procedure and at one year after surgery; 40 patients were further followed up until the 5-year mark...
July 13, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28708046/analysis-of-mtnr1b-gene-polymorphisms-in-relationship-with-irs2-gene-variants-epicardial-fat-thickness-glucose-homeostasis-and-cognitive-performance-in-the-elderly
#10
Gianluigi Mazzoccoli, Mariangela Pia Dagostino, Giulia Paroni, Davide Seripa, Filomena Ciccone, Filomena Addante, Giovanni Favuzzi, Elvira Grandone, Roberto Avola, Tommaso Mazza, Caterina Fusilli, Antonio Greco, Salvatore De Cosmo
ABSTARCT Genome-wide association studies pinpointed common variants in or near the MTNR1B gene encoding MT2 melatonin receptor to be strongly associated with fasting glucose levels. IRS2 gene polymorphisms impact insulin resistance and epicardial fat (EF) thickness, which in turn is correlated with visceral adiposity, cognitive ability and risk for metabolic plus cardiovascular disease. We aimed to discover the interactions between MTNR1B and IRS2 gene polymorphisms, insulin sensitivity, EF thickness and cognitive performance in the elderly...
July 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28707303/prediction-of-geriatric-rehabilitation-outcomes-comparison-between-three-cognitive-screening-tools
#11
Noemi Heyman, Tatyana Tsirulnicov, Merav Ben Natan
AIM: Comparison between the predictions of functional rehabilitation outcomes at a department of geriatric rehabilitation using three cognitive screening tools - Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). METHODS: This study is a prospective study. The study participants were 212 patients aged 65 and older admitted to rehabilitation departments at a geriatric facility in central Israel, from April 2016 to October 2016...
July 14, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28706726/community-based-trials-of-mobile-solutions-for-the-detection-and-management-of-cognitive-decline
#12
Adele Boyd, Jonathan Synnott, Chris Nugent, David Elliott, John Kelly
This study focused on the development and usability evaluation of EnCare diagnostics (ECD) and the brain fit plan (BFP) in healthy older adults, cognitively impaired and physically impaired individuals. ECD is proposed as a novel solution to cognitive assessment based on colour selection. BFP is a novel solution to personalised cognitive stimulation. The study consisted of two trials designed to evaluate the usability of the apps. Trial 1 involved 11 healthy older adults and four older adults with physical impairments who undertook ECD and mini-mental state examination (MMSE) once per month for 4 months with only those with physical impairments also completing the BFP daily...
June 2017: Healthcare Technology Letters
https://www.readbyqxmd.com/read/28701070/development-of-a-cognitive-function-test-using-virtual-reality-technology-examination-in-healthy-participants
#13
Hiromi Sakai, Akinori Nagano, Keiko Seki, Sayaka Okahashi, Maki Kojima, Zhiwei Luo
We developed a virtual reality test to assess the cognitive function of Japanese people in near-daily-life environment, namely, a virtual shopping test (VST). In this test, participants were asked to execute shopping tasks using touch panel operations in a "virtual shopping mall." We examined differences in VST performances among healthy participants of different ages and correlations between VST and screening tests, such as the Mini-Mental State Examination (MMSE) and Everyday Memory Checklist (EMC). We included 285 healthy participants between 20 and 86 years of age in seven age groups...
July 13, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28699630/prevalence-and-clinical-correlation-of-dysphagia-in-parkinson-disease-a-study-on-chinese-patients
#14
X Ding, J Gao, C Xie, B Xiong, S Wu, Z Cen, Y Lou, D Lou, F Xie, W Luo
BACKGROUND/OBJECTIVES: Dysphagia is relatively common in patients with Parkinson disease (PD) and can have a negative impact on their quality of life; therefore, it is imperative that its prevalence in PD patients is studied. The aim of this study was to explore the prevalence and clinical correlation of dysphagia in Chinese PD patients. SUBJECTS/METHODS: We recruited 116 Chinese PD patients. A videofluoroscopic study of swallowing (VFSS) was used to identify dysphagia...
July 12, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28699419/chair-rise-capacity-and-associated-factors-in-older-home-care-clients
#15
Miia Tiihonen, Sirpa Hartikainen, Irma Nykänen
AIMS: The aim of this study was to investigate the ability of older home-care clients to perform the five times chair rise test and associated personal characteristics, nutritional status and functioning. METHODS: The study sample included 267 home-care clients aged ≥75 years living in Eastern and Central Finland. The home-care clients were interviewed at home by home-care nurses, nutritionists and pharmacists. The collected data contained sociodemographic factors, functional ability (Barthel Index, IADL), cognitive functioning (MMSE), nutritional status (MNA), depressive symptoms (GDS-15), medical diagnoses and drug use...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28698646/plasma-biomarkers-are-associated-with-agitation-and-regional-brain-atrophy-in-alzheimer-s-disease
#16
Jung-Lung Hsu, Wei-Ju Lee, Yi-Chu Liao, Jiing-Feng Lirng, Shuu-Jiun Wang, Jong-Ling Fuh
This study investigated the relationships among plasma biomarkers, regional brain atrophy, and clinical symptoms in patients with Alzheimer's disease (AD; n = 177), mild cognitive impairment (MCI; N = 60) and controls (n = 108). The Mini-Mental Status Examination (MMSE), Clinical Dementia Rating (CDR), and Neuropsychiatric Inventory (NPI) subscales were administered to subjects. Magnetic resonance imaging was performed and medial temporal atrophy (MTA) and posterior atrophy (PA) were assessed visually...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698150/freezing-of-gait-is-associated-with-cognitive-impairment-in-patients-with-parkinson-disease
#17
Zhiwen Yao, Yuan Shao, Xiang Han
OBJECTIVE: To explore whether the cognitive impairment is correlated with freezing of gait (FOG) in patients with Parkinson disease (PD). METHODS: A total of 186 patients with Parkinson disease (104 patients with FOG and 82 patients with no clinical history of freezing behavior) and 125 healthy individuals were selected for this study. Neuropsychological assessments, including the scales for outcomes in Parkinson disease cognition, unified Parkinson's disease rating scale, and Hamilton depression/anxiety rating scale etc...
July 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28697572/delayed-recall-and-working-memory-mmse-domains-predict-delirium-following-cardiac-surgery
#18
Catherine C Price, Cynthia Garvan, Loren Hizel, Marcos G Lopez, Frederic T Billings
BACKGROUND: Reduced preoperative cognition is a risk factor for postoperative delirium. The significance for type of preoperative cognitive deficit, however, has yet to be explored and could provide important insights into mechanisms and prediction of delirium. OBJECTIVE: Our goal was to determine if certain cognitive domains from the general cognitive screener, the Mini-Mental State Exam (MMSE), predict delirium after cardiac surgery. METHODS: Patients completed a preoperative MMSE prior to undergoing elective cardiac surgery...
July 4, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28697566/reduced-cerebrospinal-fluid-concentration-of-apolipoprotein-a-i-in-patients-with-alzheimer-s-disease
#19
Per Johansson, Erik G Almqvist, Maria Bjerke, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johan Svensson
BACKGROUND: Apolipoprotein E (ApoE) has been extensively studied in Alzheimer's disease (AD), but little is known of apolipoprotein A-I (ApoA-I) in cerebrospinal fluid (CSF). OBJECTIVE: Plasma lipids as well as ApoA-I and ApoE in plasma and CSF were determined and related to Mini-Mental State Examination (MMSE) score, APOE genotype, and CSF AD biomarkers. METHODS: Consecutive patients with AD (n = 29), stable mild cognitive impairment (n = 13), other dementias (n = 14), and healthy controls (n = 18) were included at a single center...
July 5, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28697489/subjective-sleep-disturbance-in-chinese-adults-with-epilepsy-associations-with-affective-symptoms
#20
Yeru Shen, Mengmeng Zhang, Yu Wang, Lanlan Wang, Xiangjun Xu, Gairong Xiao, Jing Chen, Ting Zhang, Nong Zhou
BACKGROUND: As well as being a very common neurological disease worldwide, epilepsy significantly impairs patients' emotional, behavioral, and cognitive functioning. Sleep disturbances are the most frequent complaint in patients with epilepsy. The present study assesses the impact of a range of affective symptoms on subjective sleep quality and sleep disturbances in Chinese adults with epilepsy. METHODS: Adults with epilepsy who visited our epilepsy clinic from July 2015 to March 2016 were enrolled in our study...
July 1, 2017: Epilepsy Research
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