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https://www.readbyqxmd.com/read/27887601/protocol-for-a-prospective-randomized-study-on-neurophysiological-assessment-of-lower-urinary-tract-function-in-a-healthy-cohort
#1
Stéphanie van der Lely, Martina Stefanovic, Melanie R Schmidhalter, Marta Pittavino, Reinhard Furrer, Martina D Liechti, Martin Schubert, Thomas M Kessler, Ulrich Mehnert
BACKGROUND: Lower urinary tract symptoms are highly prevalent and a large proportion of these symptoms are known to be associated with a dysfunction of the afferent pathways. Diagnostic tools for an objective and reproducible assessment of afferent nerve function of the lower urinary tract are missing. Previous studies showed first feasibility results of sensory evoked potential recordings following electrical stimulation of the lower urinary tract in healthy subjects and patients. Nevertheless, a refinement of the methodology is necessary...
November 25, 2016: BMC Urology
https://www.readbyqxmd.com/read/27867329/caffeine-as-a-probable-factor-for-increased-risk-of-oab-development-in-elderly-people
#2
Kirill V Kosilov, Sergay A Loparev, Marina A Ivanovskaya, Liliya V Kosilova
OBJECTIVE: This study was conducted to compare overactive bladder (OAB) prevalence among people greater than 60 years of age who intake various doses of caffeine, as well as those who abstain from caffeine. PATIENTS AND METHODS: A randomized observational study was carried out in Vladivostok Gerontological Hospital. A total of 1,098 retired people greater than 60 years of age (659 women and 439 men, average age 67.1 years) took part in the study. They were admitted to the in-patient department with the purpose of annual physical examination performed in accordance with the order of the Ministry of Public Health of the Russian Federation...
October 2016: Current Urology
https://www.readbyqxmd.com/read/27845219/efficacy-of-daily-low-dose-tadalafil-for-treating-overactive-bladder-results-of-a-randomized-double-blind-placebo-controlled-trial
#3
Hongde Chen, Feng Wang, Zhixian Yu, Yirong Zhang, Chaohui Liu, Shengjie Dai, Bicheng Chen, Jiaju Lv
OBJECTIVES: To evaluate the efficacy of daily low-dose tadalafil therapy for overactive bladder (OAB) in women. PATIENTS AND METHODS: A total of 96 women with idiopathic OAB from three medical centers in the south of Zhejiang Province of China were randomly assigned to treatment with daily low-dose tadalafil (5 mg, n=48) or placebo (n=48) for 3 months. The Indevus urgency severity scale (IUSS), overactive bladder symptom score (OABSS),([2]) and a 3-day micturition diary with frequency, incontinence, and urgency episodes were recorded and compared before the treatment, every 2 weeks following the treatment, and 3 months after the treatment...
November 11, 2016: Urology
https://www.readbyqxmd.com/read/27813450/exploring-daily-blood-pressure-fluctuations-and-cardiovascular-risk-among-individuals-with-motor-complete-spinal-cord-injury-a-pilot-study
#4
Derry L Dance, Amit Chopra, Kent Campbell, David S Ditor, Magdy Hassouna, B Catharine Craven
BACKGROUND: Clinically silent autonomic dysfunction with bowel and bladder care, are postulated to contribute to cardiovascular disease after chronic spinal cord injury (SCI). OBJECTIVE: We describe the frequency and severity of dysreflexic episodes, termed transient blood pressure elevations (T-BPE) over 48 hours in adults with cervical or high-thoracic motor-complete SCI. SETTING: Tertiary SCI Rehabilitation Centre in Toronto, Canada. PARTICIPANTS: Individuals with chronic SCI, C1-T3 AIS A or B, >1 year post-injury, living in the community (n=19)...
November 4, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27802001/correlation-between-overactive-bladder-symptom-score-and-neuropsychological-parameters-in-alzheimer-s-disease-patients-with-lower-urinary-tract-symptom
#5
Ha Bum Jung, Don Kyoung Choi, Seong Ho Lee, Sung Tae Cho, Hae Ri Na, Moon Ho Park
PURPOSE: To examine an association between the overactive bladder symptom score (OABSS) and neuropsychological parameters. Moreover, we investigate the factors that affect each item in the questionnaire. MATERIALS AND METHODS: A total of 376 patients (males: 184; females: 192) with probable Alzheimer's disease (AD) were recruited. Cognitive testing was conducted using the Mini Mental Status Examination (MMSE), Clinical Dementia Rating (CDR) scale, Global Deterioration Scale (GDS), and Barthel Activities of Daily Living (ADL)...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27794164/the-association-between-the-iciq-luts-and-the-iciq-bladder-diary-in-assessing-luts
#6
Haitham Abdelmoteleb, Mohamed I Kamel, Hashim Hashim
OBJECTIVES: The bladder diary (BD) provides a non-invasive method of investigating lower urinary tract symptoms (LUTS) while the International Consultation on Incontinence Questionnaires (ICIQ) symptom questionnaires, such as the ICIQ-MLUTS and ICIQ-FLUTS for males and females, respectively, provide a subjective assessment. The association between objective and subjective assessments has not been well established for the ICIQ. MATERIALS AND METHODS: Retrospective analysis of data collected from a urodynamics database was conducted...
October 29, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27792298/potential-primary-endpoint-for-exploratory-clinical-trial-in-patients-with-overactive-bladder-a-systematic-literature-review
#7
Shingo Iino, Masayuki Kaneko, Mamoru Narukawa
OBJECTIVES: To identify a potential primary endpoint in an early-phase exploratory trial among key overactive bladder (OAB) symptoms. METHODS: Placebo-controlled double-blinding trials in patients with OAB were extracted for systematic literature review. The correlation between key OAB symptoms recorded in bladder diaries and coefficient of variation (CV) in each study were assessed. RESULTS: Forty-one controlled trials were extracted for the present review...
October 28, 2016: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/27753248/nocturia-is-often-inadequately-assessed-diagnosed-and-treated-by-physicians-results-of-an-observational-real-life-practice-database-containing-8659-european-and-us-american-patients
#8
Matthias Oelke, Peter Anderson, Robert Wood, Tove Holm-Larsen
AIMS: The aim of this study was to investigate the quality and timing of the diagnosis and treatment of nocturia in real-life practice in European and US-American patients to obtain better insights into the management of nocturia in different Western healthcare systems. METHODS: Data were drawn from the "LUTS Disease Specific Programme," a real-life survey of physicians and patients in France, Germany, Spain, UK and the USA. Physicians completed a patient record form for lower urinary tract symptoms (LUTS) patients...
November 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27752750/methodology-for-a-trial-of-brain-centered-versus-anticholinergic-therapy-in-women-with-urgency-urinary-incontinence
#9
Yuko M Komesu, Rebecca G Rogers, Robert E Sapien, Ronald M Schrader, Timothy Simmerman-Sierra, Andrew R Mayer, Loren H Ketai
INTRODUCTION AND HYPOTHESIS: We describe the rationale and methodology for a study comparing mind-body treatment and pharmacotherapy in women with urgency urinary incontinence (UUI). To explore brain associations in UUI, a subset of patients will also undergo functional magnetic resonance imaging (fMRI). We hypothesize that hypnotherapy, a mind-body intervention, will be at least as effective as pharmacotherapy in treating UUI. We also hypothesize that fMRI findings will change following treatment, with changes potentially differing between groups...
October 17, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27744492/nocturnal-enuresis-in-children-between-laser-acupuncture-and-medical-treatment-a-comparative-study
#10
Jehan Alsharnoubi, Adly A Sabbour, Ahmed I Shoukry, Amany M Abdelazeem
Nocturnal enuresis (NE) is intermittent involuntary voiding during sleep in a child aged 5 years or more. The study was conducted to compare the effect of using laser acupuncture and medication for the treatment of children with nocturnal enuresis (NE) and evaluation of urodynamic parameter after treatment. A randomized study included 45 children ranged from 5 to 15 years presenting with NE. They were randomized into three equal groups-group A, managed with desmopressin acetate; group B, managed with laser acupuncture; and group C, managed with a combination of laser acupuncture and desmopressin-all groups received behavioral therapy...
October 15, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27738739/methodology-for-a-vaginal-and-urinary-microbiome-study-in-women-with-mixed-urinary-incontinence
#11
Yuko M Komesu, Holly E Richter, Darrell L Dinwiddie, Nazema Y Siddiqui, Vivian W Sung, Emily S Lukacz, Beri Ridgeway, Lily A Arya, Halina M Zyczynski, Rebecca G Rogers, Marie Gantz
INTRODUCTION AND HYPOTHESIS: We describe the rationale and methods of a study designed to compare vaginal and urinary microbiomes in women with mixed urinary incontinence (MUI) and similarly aged, asymptomatic controls. METHODS: This paper delineates the methodology of a supplementary microbiome study nested in an ongoing randomized controlled trial comparing a standardized perioperative behavioral/pelvic floor exercise intervention plus midurethral sling versus midurethral sling alone for MUI...
October 13, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27736908/urodynamic-investigation-a-valid-tool-to-define-normal-lower-urinary-tract-function
#12
Lorenz Leitner, Matthias Walter, Ulla Sammer, Stephanie C Knüpfer, Ulrich Mehnert, Thomas M Kessler
OBJECTIVES: To evaluate whether urodynamic investigation (UDI), the gold standard to assess refractory lower urinary tract symptoms (LUTS), is appropriate to select healthy volunteers with apparent normal lower urinary tract function as control subjects for comparative studies. SUBJECTS AND METHODS: 42 healthy subjects (22 women, mean age 32±10 years; 20 men, mean age 37±12 years) without LUTS were included into this prospective single-centre cohort study. All subjects recorded a 3-day bladder diary, completed validated questionnaires regarding LUTS, and underwent neuro-urological assessment as well as free uroflowmetry...
2016: PloS One
https://www.readbyqxmd.com/read/27706009/social-economic-and-medical-factors-associated-with-solifenacin-therapy-compliance-among-workers-who-suffer-from-lower-urinary-tract-symptoms
#13
Kirill Vladimirovich Kosilov, Loparev Sergay Alexandrovich, Kuzina Irina Gennadyevna, Shakirova Olga Viktorovna, Zhuravskaya Natalia Sergeevna, Ankudinov Ivan Ivanovich
PURPOSE: The prevalence of hyperactive-type lower urinary tract symptoms is 45.2%, with shares of overactive bladder (OAB) and urge incontinence (UI) symptoms of 10.7% and 8.2%, respectively. We investigated the possible impact of a wide range of social, economic, and medical factors on compliance with solifenacin treatment in the working population. METHODS: Social, economic, and medical factors as well as the Overactive Bladder questionnaire - the OAB-q Short Form (OAB-q SF), bladder diaries, and uroflowmetry of 1,038 people who were administered solifenacin for a year were gathered from employer documentation...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27701987/efficacy-and-safety-of-bladder-hydrodistension-for-decreased-bladder-capacity-induced-by-intravesical-bcg-therapy
#14
Kazuyuki Numakura, Norihiko Tsuchiya, Hiroshi Tsuruta, Susumu Akihama, Mitsuru Saito, Takamitsu Inoue, Shintaro Narita, Mingguo Huang, Shigeru Satoh, Tomonori Habuchi
OBJECTIVE: Intravesical BCG therapy is widely used for the treatment of high-risk, non-muscle-invasive bladder cancer. Among various reported side-effects, decreased bladder capacity is a serious side-effect that significantly worsens patients' quality of life. This article reports the efficacy and safety of bladder hydrodistension (BHD) in six patients with seriously decreased bladder capacity caused by BCG treatment. METHODS: Six patients with low bladder capacity (<100 ml in voiding diaries) and complaint of grade 3 irritative symptoms were diagnosed with decreased bladder capacity and treated with BHD...
October 5, 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27701661/onabotulinumtoxina-vs-sacral-neuromodulation-on-refractory-urgency-urinary-incontinence-in-women-a-randomized-clinical-trial
#15
Cindy L Amundsen, Holly E Richter, Shawn A Menefee, Yuko M Komesu, Lily A Arya, W Thomas Gregory, Deborah L Myers, Halina M Zyczynski, Sandip Vasavada, Tracy L Nolen, Dennis Wallace, Susan F Meikle
Importance: Women with refractory urgency urinary incontinence are treated with sacral neuromodulation and onabotulinumtoxinA with limited comparative information. Objective: To assess whether onabotulinumtoxinA is superior to sacral neuromodulation in controlling refractory episodes of urgency urinary incontinence. Design, Setting, and Participants: Multicenter open-label randomized trial (February 2012-January 2015) at 9 US medical centers involving 381 women with refractory urgency urinary incontinence...
October 4, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27696622/virtue-male-sling-for-post-prostatectomy-stress-incontinence-a-prospective-evaluation-and-mid-term-outcomes
#16
Matteo Ferro, Danilo Bottero, Carolina D'Elia, Deliu Victor Matei, Antonio Cioffi, Gabriele Cozzi, Alessandro Serino, Giovanni Cordima, Roberto Bianchi, Piero Giacomo Incarbone, Antonio Brescia, Gennaro Musi, Ferdinando Fusco, Serena Detti, Vincenzo Mirone, Ottavio de Cobelli
OBJECTIVE: To evaluate the efficacy and safety of the Virtue(®) male sling (Coloplast, Humlebaek, Denmark) in a cohort of patients affected by post-prostatectomy stress urinary incontinence (SUI). METHODS: All 29 consecutive patients treated with a Virtue male sling at our Institution between July 2012 and October 2013 were included in the present prospective, non-randomized study. Patients were evaluated preoperatively and at 1, 3, 6, 12, 24 and 36 months after surgery using a 24-h pad weight test, the International Consultation on Incontinence short-form questionnaire (ICIQ-SF), Urinary Symptom Profile (USP) questionnaire, a bladder diary, uroflowmetry and the Patient Global Impression of Improvement (PGI-I) and Patient Global Impression of Severity questionnaires...
October 3, 2016: BJU International
https://www.readbyqxmd.com/read/27686226/comparison-of-mirabegron-and-imidafenacin-for-efficacy-and-safety-in-japanese-female-patients-with-overactive-bladder-a-randomized-controlled-trial-comfort-study
#17
Atsushi Otsuka, Shinji Kageyama, Takahisa Suzuki, Rikiya Matsumoto, Hiroshi Nagae, Motoaki Kitagawa, Hiroshi Furuse, Seiichiro Ozono
OBJECTIVES: To evaluate the efficacy and safety of mirabegron compared with imidafenacin for the treatment of female patients with overactive bladder. METHODS: Patients (n = 89) were randomized to receive 0.1 mg imidafenacin twice daily (n = 47) or 50 mg mirabegron once daily (n = 42) for 12 weeks. The primary efficacy end-point was change in total Overactive Bladder Symptom Score. Secondary efficacy end-points included change in Overactive Bladder Symptom Score, 3-day micturition diary, International Prostate Symptom Score and Overactive Bladder Questionnaire...
December 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27679448/treatment-options-for-urogenital-dysfunction-in-parkinson-s-disease
#18
REVIEW
Amit Batla, Natalie Tayim, Mahreen Pakzad, Jalesh N Panicker
Urogenital dysfunction is commonly reported in Parkinson's disease (PD), and history taking and a bladder diary form the cornerstone of evaluation. The assessment of lower urinary tract (LUT) symptoms include urinalysis, ultrasonography, and urodynamic studies and help to evaluate concomitant urological pathologies such as benign prostate enlargement. Antimuscarinic medications are the first line treatment for overactive bladder (OAB) symptoms and solifenacin has been specifically studied in PD. Antimuscarininc drugs may exacerbate PD-related constipation and xerostomia, and caution is advised when using these medications in individuals where cognitive impairment is suspected...
October 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27676460/the-impact-of-prior-back-surgery-on-neuromodulation-outcomes-a-review-of-over-500-patients
#19
Jamie M Bartley, Kim A Killinger, Judith A Boura, Priyanka Gupta, Natalie Gaines, Jason P Gilleran, Kenneth M Peters
AIMS: To evaluate neuromodulation outcomes in patients with prior back surgery. METHODS: Adults in our prospective observational sacral/pudendal neuromodulation study were retrospectively evaluated. History and operative details were reviewed, and outcomes were measured at 3, 6, 12, and 24 months with overactive bladder questionnaire (OAB q) symptom severity (SS)/health related quality of life (HRQOL), interstitial cystitis symptom/problem indices (ICSI - PI), voiding diaries, and global response assessments (GRA)...
September 27, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27636222/outcomes-of-sacral-neuromodulation-in-patients-with-prior-surgical-treatment-of-stress-urinary-incontinence-and-pelvic-organ-prolapse
#20
Jamie M Bartley, Verity Ramirez, Kim A Killinger, Judith A Boura, Priyanka Gupta, Natalie Gaines, Jason P Gilleran, Kenneth M Peters
OBJECTIVES: The aim of this study was to evaluate the efficacy of sacral neuromodulation in patients with prior stress urinary incontinence (SUI) or pelvic organ prolapse (POP) surgery. METHODS: Women in our prospective neuromodulation database were evaluated. Patients with a history of prior SUI/POP surgery were compared to those without. Medical records at baseline were reviewed, and primary outcome was defined as moderate/marked improvement on Global Response Assessment (GRA) at 3 months...
September 15, 2016: Female Pelvic Medicine & Reconstructive Surgery
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