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https://www.readbyqxmd.com/read/29334338/at-home-genital-nerve-stimulation-for-individuals-with-sci-and-neurogenic-detrusor-overactivity-a-pilot-feasibility-study
#1
Dennis J Bourbeau, Kenneth J Gustafson, Steven W Brose
OBJECTIVE: Neurogenic bladder dysfunction, including neurogenic detrusor overactivity (NDO) is one of the most clinically significant problems for persons with spinal cord injury (SCI), affecting health and quality of life. Genital nerve stimulation (GNS) can acutely inhibit NDO-related reflex bladder contractions and increase bladder capacity. However, it is unknown if GNS can improve urinary continence or help meet individuals' bladder management goals during sustained use, which is required for GNS to be clinically effective...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29322401/is-it-possible-to-cure-the-symptoms-of-the-overactive-bladder-in-women
#2
Jan Krhut, Alois Martan, Roman Zachoval, Tomas Hanus, Lukas Horcicka, Kamil Svabík, Peter Zvara
PURPOSE: To evaluate the feasibility of discontinuing treatment with mirabegron once symptoms have subsided in patients with overactive bladder (OAB). METHODS: The present study evaluated a total of 159 female OAB patients (age 62.9 ± 12.36), each of which were prescribed 50 mg/day mirabegron (Time point 1-T1). Data obtained from voiding diaries and patient-reported outcome variables were assessed during follow-up visits at months 1, 3, 6, 12, 18 (T2), and 21 (T4)...
January 10, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29315785/three-month-clinical-results-with-a-rechargeable-sacral-neuromodulation-system-for-the-treatment-of-overactive-bladder
#3
Bertil Blok, Philip Van Kerrebroeck, Stefan de Wachter, Alain Ruffion, Frank Van der Aa, Ranjana Jairam, Marie Perrouin-Verbe, Sohier Elneil
AIMS: The primary aim of the RELAX-OAB study is to confirm the safety and efficacy of the Axonics r-SNM System, a miniaturized, rechargeable SNM system. METHODS: A total of 51 OAB patients were implanted in a single-stage implant procedure. These results represent the 3-month outcomes. Subject outcomes were evaluated using 3-day bladder diaries and quality of life questionnaires. RESULTS: A total of 31 of 34 patients (91%) that responded during an initial trial period ("Test Responders") continued to benefit from therapy with the Axonics r-SNM System at 3-months, defined as symptom improvement of ≥50% reduction in urinary voids or incontinence episodes or a return to <8 voids per day...
January 5, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29307733/safety-and-feasibility-of-intravesical-instillation-of-botulinum-toxin-a-in-hydrogel-based-slow-release-delivery-system-in-interstitial-cystitis-bladder-pain-syndrome-patients-a-pilot-study
#4
Yishai H Rappaport, Amnon Zisman, Michal Jeshurun-Gutshtat, Tami Gerassi, Gil Hakim, Yuri Vinshtok, Kobi Stav
OBJECTIVE: To assess feasibility and safety of a mixture instillation of TC-3 Gel, a novel reverse-thermal gelation hydrogel, and botulinum toxin-A (BTX-A) for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS). TC-3 Gel/BTX-A mix is instilled into the bladder as liquid, solidifies due to body heat and gradually dissolves to release BTX-A for several hours. METHODS: A single intravesical instillation of 200U BTX-A premixed with 40ml TC-3 Gel was delivered to the bladder...
January 4, 2018: Urology
https://www.readbyqxmd.com/read/29300259/sleep-quality-and-daytime-sleepiness-among-women-with-urgency-predominant-urinary-incontinence
#5
William D Winkelman, Ann Warsi, Alison J Huang, Michael Schembri, Rebecca G Rogers, Holly E Richter, Deborah L Myers, Stephen R Kraus, Karen C Johnson, Rachel Hess, Thomas Gregory, Catherine S Bradley, Lily A Arya, Jeanette S Brown, Katie L Stone, Leslee L Subak
OBJECTIVE: The objective of this study was to examine the strength and direction of the association between urinary symptoms and both poor quality sleep and daytime sleepiness among women with urgency urinary incontinence. METHODS: A planned secondary analysis of baseline characteristics of participants in a multicenter, double-blinded, 12-week randomized controlled trial of pharmacologic therapy for urgency-predominant urinary incontinence in ambulatory women self-diagnosed by the 3 Incontinence Questions was performed...
January 3, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29298468/radiographic-position-of-the-electrode-as-a-predictor-of-the-outcome-of-interstim-therapy
#6
Abdullah Ahmed Gahzi, Mai Ahmed Banakhar, Dean S Elterman, Magdy Hassouna
PURPOSE: Sacral neuromodulation (SNM) therapy is indicated for some refractory urological conditions. The electrode lead position in sacral x-rays during routine follow-up may predict the outcome of SNM therapy. To determine whether the radiographic position of the electrode in the sacral foramen predicted the long-term outcome of SNM therapy. METHODS: This was a retrospective study of patients who underwent InterStim SNM at Toronto Western Hospital by 2 surgeons from July 2013 to March 2014...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29298466/urinary-nerve-growth-factor-as-a-potential-biomarker-of-treatment-outcomes-in-overactive-bladder-patients
#7
Yoon Seok Suh, Kwang Jin Ko, Tae Heon Kim, Hyo Serk Lee, Hyun Hwan Sung, Won Jin Cho, Kyu-Sung Lee
PURPOSE: The aim of this study was to investigate urinary nerve growth factor (NGF) as a biomarker of treatment efficacy and recurrence in overactive bladder (OAB) patients. METHODS: We enrolled 189 OAB subjects who visited our outpatient clinic from February 2010 to February 2015. All subjects with OAB received antimuscarinic treatment. A 3-day voiding diary and questionnaire were collected from each patient. Urinary levels of NGF were evaluated at baseline, the beginning of antimuscarinic treatment, and the end of antimuscarinic treatment...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29291416/onset-of-action-of-sacral-neuromodulation-in-lower-urinary-tract-dysfunction-what-is-the-optimal-duration-of-test-stimulation
#8
R Jairam, J Drossaerts, T Marcelissen, G van Koeveringe, Ph Van Kerrebroeck
PURPOSE: Since the development of sacral neuromodulation (SNM) a large number of patients with lower urinary tract symptoms (LUTS) have been treated with SNM. A test stimulation is performed prior to implantation. In centres worldwide the duration of this test stimulation varies considerably since it is not certain when the onset of the therapy effect can be expected. The objective of this prospective study is to evaluate the average onset time of SNM in patients with LUTS. METHODS: All patients who were eligible for treatment with SNM were asked to participate...
December 29, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29260636/effective-treatment-of-neurogenic-detrusor-overactivity-in-multiple-sclerosis-patients-using-desmopressin-and-mirabegron
#9
Athanasios Zachariou, Maria Filiponi, Dimitrios Baltogiannis, John Giannakis, Fotios Dimitriadis, Panagiota Tsounapi, Atsushi Takenaka, Nikolaos Sofikitis
INTRODUCTION: Multiple sclerosis (MS) is the commonest progressive neurological disease affecting young people. With advancing disease, management of neurogenic detrusor overactivity (NDO) based on antimuscarinics may prove inadequate and if based on botulinum toxin, may necessitate clean intermittent self-catheterization. The aim of the study was to evaluate the effectiveness of combined mirabegron and desmopressin administration in the treatment of NDO in patients with MS. MATERIALS AND METHODS: Sixty patients diagnosed with MS and NDO were evaluated...
December 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29229221/intravesical-electromotive-botulinum-toxin-type-a-administration-for-management-of-urinary-incontinence-secondary-to-neuropathic-detrusor-overactivity-in-children-long-term-follow-up
#10
Seyedeh-Sanam Ladi-Seyedian, Lida Sharifi-Rad, Abdol-Mohammad Kajbafzadeh
OBJECTIVES: To investigate the long-term efficacy and success rate of intravesical electromotive botulinum toxin type A (BoNTA) "Dysport®" administration in myelomeningocele (MMC) patients who had urinary incontinence due to neuropathic detrusor overactivity (NDO). METHODS: Twenty four MMC patients (mean age: 9± 3.6 years, range: 3-16) were included in the study and followed up for six years. Using an electrode bladder catheter, 10 IU/kg of Dysport® (BoNTA) was inserted into the bladder for electromotive drug administration (EMDA) without anesthesia on outpatient basis...
December 8, 2017: Urology
https://www.readbyqxmd.com/read/29224251/efficacy-and-safety-of-fesoterodine-treatment-for-overactive-bladder-symptoms-in-elderly-women-with-and-without-hypertension
#11
Osamu Yokoyama, Hidetomi Yamagami, Shintaro Hiro, Shinichi Hotta, Masaki Yoshida
OBJECTIVE: To assess fesoterodine treatment in elderly women with overactive bladder with and without hypertension. METHODS: Data for 2527 elderly women with overactive bladder symptoms, including urgency urinary incontinence, were pooled from 10 double-blind, placebo-controlled fesoterodine studies. RESULTS: A total of 1523 elderly women (60.3%) had a history of hypertension, and 1004 women (39.7%) had no hypertension history. Overactive bladder symptoms, mean bodyweight and mean body mass index at baseline were significantly higher in women with overactive bladder and hypertension versus those without hypertension (P < 0...
December 10, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29217876/nocturnal-enuresis-in-india-are-we-diagnosing-and-managing-correctly
#12
REVIEW
N M Reddy, H Malve, R Nerli, P Venkatesh, I Agarwal, V Rege
Nocturnal enuresis is a common problem affecting school-aged children worldwide. Although it has significant impact on child's psychology, it is always under-recognized in India and considered as a condition which will outgrow with advancing age. Nocturnal enuresis classified as primary or secondary and monosymptomatic or nonmonosymptomatic. Factors that cause enuresis include genetic factors, bladder dysfunction, psychological factors, and inappropriate antidiuretic hormone secretion, leading to nocturnal polyuria...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29175540/the-effect-of-family-assistance-to-wake-children-with-monosymptomatic-enuresis-in-alarm-therapy-a-pilot-study
#13
Shoji Tsuji, Chikushi Suruda, Takahisa Kimata, Jiro Kino, Sohsaku Yamanouchi, Kazunari Kaneko
PURPOSE: Alarm therapy is widely used as first-line treatment for nocturnal enuresis (NE). However, some children do not wake when nocturnal urination activates the alarm. It is currently unclear whether waking the child when the alarm is activated improves the efficacy of alarm therapy. This study aimed to investigate the efficacy of alarm therapy for NE when children do not wake in response to the sound and their parents do not wake them. MATERIALS AND METHODS: Detailed information regarding incontinence was retrospectively obtained from 78 of 112 patients who underwent alarm therapy between 2006 and 2016 and completed a questionnaire and a 14-day bladder diary...
November 23, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29175111/metabolomics-approach-for-male-lower-urinary-tract-symptoms-an-identification-of-possible-biomarkers-and-potential-targets-for-new-treatments
#14
Takahiko Mitsui, Satoru Kira, Tatsuya Ihara, Norifumi Sawada, Hiroshi Nakagomi, Tatsuya Miyamoto, Hiroshi Shimura, Hiroshi Yokomichi, Masayuki Takeda
OBJECTIVES: We identified metabolites using a metabolomics approach and investigated the association between these metabolites and lower urinary tract symptoms (LUTS). METHODS: A 24-hr bladder diary and International Prostate Symptom Score (IPSS) were used to assess micturition behaviors and LUTS in a total of 58 male patients without apparent neurological diseases. LUTS was defined as a total IPSS score of ≥8 (the LUTS-group), while patients with a score of <7 were placed in the Control-group...
November 21, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29145873/group-physiotherapy-compared-to-individual-physiotherapy-to-treat-urinary-incontinence-in-aging-women-study-protocol-for-a-randomized-controlled-trial
#15
Chantale Dumoulin, Mélanie Morin, Marie-Hélène Mayrand, Michel Tousignant, Michal Abrahamowicz
BACKGROUND: Urinary incontinence (UI), one of the most prevalent health concerns confronting women aged over 60 years, affects up to 55% of older community-dwelling women-20-25% with severe symptoms. Clinical practice guidelines recommend individualized pelvic floor muscle training (PFMT) as a first-line treatment for stress or mixed UI in women, although lack of human and financial resources limits delivery of this first-line treatment. Preliminary data suggest that group-based treatments may provide the answer...
November 16, 2017: Trials
https://www.readbyqxmd.com/read/29057583/a-medical-device-containing-purified-bovine-colostrum-monurelle-biogel-in-the-treatment-of-vulvovaginal-atrophy-in-postmenopausal-women-retrospective-analysis-of-urinary-symptoms-sexual-function-and-quality-of-life
#16
M C Schiavi, C Di Tucci, V Colagiovanni, P Faiano, A Giannini, O D'Oria, G Prata, G Perniola, M Monti, M A Zullo, L Muzii, P Benedetti Panici
OBJECTIVE: This study assessed the effectiveness and safety of a medical device containing purified bovine colostrum (Monurelle Biogel; Zambon, Bresso, Italy) in improving vulvovaginal atrophy (VVA), sexual function, urinary symptoms, and quality of life (QoL) in postmenopausal women. METHODS: In all, 172 postmenopausal women with VVA were included in the study. All women were treated with vaginal Monurelle Biogel daily for 12 weeks. Patients underwent clinical examinations, completed a 3-day voiding diary, and had VVA graded using the Vaginal Health Index (VHI) at baseline and 12 weeks...
October 23, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29042069/mind-over-bladder-women-aging-and-bladder-health
#17
Joanna E Long, Saif Khairat, Elizabeth Chmelo, Mary H Palmer
The purpose of this study was to explore the efficacy and acceptability of an innovative, electronically delivered self-management intervention for urinary incontinence (UI) that included daily mindfulness practice, completion of sequential bladder diaries, and bladder health education to improve UI in older women living independently in a retirement community. A mixed methods pilot study was conducted over ten weeks using a custom website or CD. Ten women were recruited and 8 completed the study; 5 of those (71%) experienced fewer daily UI episodes post intervention (p = 0...
October 14, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29031894/refractory-urgency-urinary-incontinence-treatment-in-women-impact-of-age-on-outcomes-and-complications
#18
Yuko M Komesu, Cindy L Amundsen, Holly E Richter, Stephen W Erickson, Mary F Ackenbom, Uduak U Andy, Vivian W Sung, Michael Albo, W Thomas Gregory, Marie Fidela Paraiso, Dennis Wallace
BACKGROUND: Women with refractory urgency urinary incontinence (ie, unresponsive to behavioral and pharmacological interventions) are treated with onabotulinumtoxinA or sacral neuromodulation. OBJECTIVE: The objective of the study was to compare treatment efficacy and adverse events in women <65 and ≥65 years old treated with onabotulinumtoxinA or sacral neuromodulation. STUDY DESIGN: This study was a planned secondary analysis of a multicenter, randomized trial that enrolled community-dwelling women with refractory urgency urinary incontinence to onabotulinumtoxinA or sacral neuromodulation treatments...
October 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28975365/effects-of-urine-alkalinization-with-sodium-bicarbonate-orally-on-lower-urinary-tract-symptoms-in-female-patients-a-pilot-study
#19
Mehmet Giray Sönmez, Yunus Emre Göğer, Gökhan Ecer, Ahmet Atıcı, Mehmet Serkan Özkent, Ahmet Öztürk
INTRODUCTION AND HYPOTHESIS: In this study, we planned to explore the effects of sodium bicarbonate orally (NaHCO3) treatment on female patients with lower urinary tract symptoms (LUTS) who have acidic urine pH values (<6). METHODS: NaHCO3 was given orally to 33 female patients for 4 weeks at a dose of 2 × 4 g/day. Laboratory values, bladder diary, the Patient Perception of Bladder Condition Score (PPBC), Patient Perception of Intensity of Urgency Scale (PPIUS), Overactive Bladder-Validated 8-question Awareness tool (OAB-V8), Pelvic Pain and Urgency & Frequency Patient Symptom Scale tests (PUFSS), and the King's Health Questionnaire (KHQ) scores before and after treatment were compared...
October 3, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28967986/long-term-functional-outcomes-of-s3-sacral-neuromodulation-for-the-treatment-of-idiopathic-overactive-bladder
#20
Salima Ismail, Emmanuel Chartier-Kastler, Marie-Aimée Perrouin-Verbe, Johan Rose-Dite-Modestine, Pierre Denys, Véronique Phé
OBJECTIVES: To assess the long-term functional outcomes of sacral neuromodulation (SNM) in the treatment of refractory idiopathic overactive bladder (IOAB) and to determine predictive factors for success. MATERIALS AND METHODS: To obtain long-term data, all consecutive patients suffering from IOAB and treated by SNM at a single tertiary care center between December 1996 and December 2004 were included. Data regarding patient demographics, past medical, and surgical history, bladder diary, complications as well as device revision and removal rates were collected...
October 2, 2017: Neuromodulation: Journal of the International Neuromodulation Society
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