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https://www.readbyqxmd.com/read/28916436/treating-overactive-bladder-in-older-patients-with-a-combination-of-mirabegron-and-solifenacin-a-prespecified-analysis-from-the-beside-study
#1
William Gibson, Scott MacDiarmid, Moses Huang, Emad Siddiqui, Matthias Stölzel, Nurul Choudhury, Marcus J Drake
BACKGROUND: The BESIDE study demonstrated that combination therapy (mirabegron and solifenacin 5mg) improved overactive bladder symptoms versus solifenacin 5mg or 10mg, and was well tolerated. OBJECTIVE: To ensure efficacy and safety is maintained in older patients (>65 yr), who usually experience greater symptom severity and comorbidities, a prespecified subanalysis stratified by age group was conducted. DESIGN, SETTING, AND PARTICIPANTS: Patients remaining incontinent (≥1 episode during 3-d diary) following 4-wk single-blind daily solifenacin 5mg were randomized 1:1:1 to a daily double-blind combination (solifenacin 5mg and mirabegron 25mg, increased to 50mg at wk 4), solifenacin 5mg or 10mg for 12 wk...
September 12, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28914707/prospective-randomized-feasibility-study-assessing-the-effect-of-cyclic-sacral-neuromodulation-on-urinary-urge-incontinence-in-women
#2
Steven Siegel, Karl Kreder, Elizabeth Takacs, Rachael McNamara, Fangyu Kan
OBJECTIVES: The aim of this prospective, randomized, multicenter, single-blind, 4 × 4 crossover study was to estimate the effect of 4 InterStim cycling settings (continuous, 16 seconds on/8 seconds off, 10 minutes on/10 minutes off, and 30 minutes on/23.5 hours off) on efficacy, Global Response Assessment, and safety. METHODS: Eligible women implanted for at least 3 months for urgency urinary incontinence (UI) were enrolled, and daily diaries were collected. General linear mixed models were used to estimate the cycling effect on efficacy...
September 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28892221/a-novel-leadless-miniature-implantable-tibial-nerve-neuromodulation-system-for-the-management-of-overactive-bladder-complaints
#3
John P F A Heesakkers, Guiseppe A Digesu, Jetske van Breda, Philip Van Kerrebroeck, Sohier Elneil
BACKGROUND: Overactive bladder is a chronic condition affecting lower urinary tract function that has a significant negative impact on QoL. OBJECTIVE: Evaluation of the BlueWind implantable tibial nerve system performance and safety in refractory OAB. DESIGN, SETTING, AND PARTICIPANTS INTERVENTION: A 6-month multi-center prospective intervention study. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Objective assessment was done by voiding diary parameters included voids/day, volume voided/day, urgency assessment, leaking episodes/day, pads used/day, leak severity, and clinical success defined as a ≥50% reduction in the number of leaks/day or number of voids/day or number of episodes with degree of urgency >2 or a return to <8 voids/day on a 3 Day diary...
September 11, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28877395/optimal-lead-positioning-in-sacral-neuromodulation-which-factors-are-related-to-treatment-outcome
#4
Ranjana Jairam, Tom Marcelissen, Gommert van Koeveringe, Philip van Kerrebroeck
OBJECTIVES: Sacral neuromodulation (SNM) is a well-established treatment for overactive bladder (OAB) and non-obstructive urinary retention (NOR). During test stimulation, the lead is positioned along the third sacral nerve, which ideally results in a response in all four contact points (active electrodes). However, it is unclear whether the position of the lead (depth, angle, deflection) and the number of active electrodes is related to the outcome of SNM. METHODS: All patients who underwent test stimulation using the tined lead between January 2011 and September 2016 were included in this retrospective study...
September 6, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28871426/assessment-of-overactive-bladder-symptoms-among-women-with-successful-pessary-placement
#5
Dimitrios Zacharakis, Themos Grigoriadis, Eleni Pitsouni, Kostas Kypriotis, Nikistratos Vogiatzis, Stavros Athanasiou
INTRODUCTION AND HYPOTHESIS: The causal association between pelvic organ prolapse (POP) and overactive bladder (OAB) symptoms is supported by several theories. The aim of this study is to assess any changes in OAB symptoms among women with POP and OAB after successful pessary placement. METHODS: During the study period, all women with symptomatic POP stage II or greater and OAB symptoms were offered the solution of either a ring or a Gellhorn pessary. All patients were asked to complete a 3-day micturition/incontinence diary...
September 4, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28868507/evaluation-of-the-incidence-and-risk-factors-associated-with-persistent-frequency-in-interstitial-cystitis-bladder-pain-syndrome-and-the-efficacy-of-antimuscarinic-treatment
#6
Aram Kim, Kyeong-Ok Hoe, Jung Hyun Shin, Myung-Soo Choo
PURPOSE: To investigate the incidence and risk factors associated with persistent urinary frequency, and to evaluate the efficacy of antimuscarinic treatment. MATERIALS AND METHODS: Interstitial cystitis/bladder pain syndrome (IC/BPS) patients complaining of persistent urinary frequency despite improved pain were evaluated. Before initial conventional treatment, each patient completed a voiding diary and symptom questionnaires. After conventional treatment, patients were divided according to the presence of pain and frequency...
September 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28857434/self-consciousness-awareness-and-bladder-sensations-comparative-study-of-overactive-bladder-patients-and-healthy-volunteers
#7
Desiree Vrijens, Tom Marcelissen, Jamie Drossaerts, Rhea Heeringa, Sam Degaillier, Carsten Leue, Gommert van Koeveringe
OBJECTIVES: To explore differences in bladder sensations between patients with overactive bladder (OAB) and healthy volunteers by evaluating self-consciousness, self-awareness and affective complaints. METHODS: A prospective, observational study was performed comparing patients with OAB symptoms and healthy volunteers. During 3 days subjects filled out sensation-related bladder diaries (SR-BD), Self-Consciousness Questionnaires (SCS), Self-Awareness Questionnaire (SSAS) and the Hospital Anxiety and Depression Scale (HADS)...
August 31, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28828529/clinical-management-of-nocturnal-enuresis
#8
Eberhard Kuwertz-Bröking, Alexander von Gontard
Nocturnal enuresis (NE) is a common health problem. Approximately 10% of 7-year-old children wet the bed regularly during sleep. Enuresis can be categorized into monosymptomatic (MEN) and nonmonosymptomatic (NMEN) forms. MEN occurs without any other symptoms of bladder dysfunction. NMEN is associated with dysfunction of the lower urinary tract with or without daytime incontinence. The rate of comorbid gastrointestinal, behavioral, and emotional disorders is elevated depending upon the subtype of NE. A careful clinical history is fundamental to the evaluation of enuresis...
August 21, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28815547/adjustable-mini-sling-compared-to-conventional-mid-urethral-slings-in-women-with-urinary-incontinence-a-randomized-controlled-trial
#9
Martin Rudnicki, Katarina von Bothmer-Ostling, Anja Holstad, Claes Magnusson, Memona Majida, Constanze Merkel, Jens Prien, Ulf Jakobsson, Pia Teleman
INTRODUCTION: The primary aim was to compare the objective and subjective outcomes and short-term complication rates of an adjustable single-incision mini-sling (SIMS) versus standard mid-urethral slings (SMUS). The secondary aim was reporting pain perception and complications at one-year follow-up. MATERIAL AND METHODS: The study was designed as a multicenter prospective randomized trial where women were included by eight centers in Denmark, Norway and Sweden. The trial was registered at ClinicalTrials...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28792105/transcutaneous-posterior-tibial-nerve-electrostimulation-with-low-dose-trospium-chloride-could-it-be-used-as-a-second-line-treatment-of-overactive-bladder-in-females
#10
Amr Abulseoud, Ahmed Moussa, Gaber Abdelfattah, Ibrahim Ibrahim, Emmanuel Saba, Mohamed Hassouna
AIM: To evaluate the effect of adding low dose trospium chloride with transcutaneous posterior tibial nerve stimulation (TPTNS) in the treatment of overactive bladder (OAB) in females after failure of behavioral therapy. METHODS: We randomized 30 women with OAB, in two groups: G I received 30 min TPTNS, three times a week; GII received TPTNS plus 20 mg trospium chloride daily. OAB Symptom Score questionnaire (OABSS), Incontinence Impact Questionnaire-short form 7 (IIQ-7), 3 day voiding diary and urodynamics at weeks 0 and 8 were evaluated...
August 9, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28714288/tolterodine-treatment-of-women-with-overactive-bladder-syndrome-comparison-of-night-time-and-daytime-dosing-for-nocturia
#11
Ko-Hsin Tsai, Sheng-Mou Hsiao, Ho-Hsiung Lin
AIM: We aimed to clarify the impact of night-time dosing with tolterodine extended release (ER) on nocturia. METHODS: The bladder diaries, urodynamic studies, and medical records of female patients with overactive bladder syndrome who were diagnosed between January 2005 and December 2015, and treated with tolterodine ER 4 mg once per day (night-time or daytime dosing) for 12 weeks in the urogynecology outpatient clinics of two tertiary referral centers were reviewed retrospectively...
July 16, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28681036/additional-low-dose-antimuscarinics-can-improve-overactive-bladder-symptoms-in-patients-with-suboptimal-response-to-beta-3-agonist-monotherapy
#12
Jung Hyun Shin, Aram Kim, Myung-Soo Choo
PURPOSE: We aimed to assess the patient-reported outcome (PRO) and efficacy of add-on low-dose antimuscarinic therapy in over-active bladder (OAB) patients with suboptimal response to 4-week treatment with beta 3 agonist monotherapy (mirabegron, 50 mg). MATERIALS AND METHODS: We enrolled OAB patients with 4-week mirabegron (50 mg) treatment if the patients' symptoms improved, but not to a satisfactory extent (patient perception of bladder condition [PPBC] ≥4)...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28655016/effect-of-electroacupuncture-on-urinary-leakage-among-women-with-stress-urinary-incontinence-a-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Zhishun Liu, Yan Liu, Huanfang Xu, Liyun He, Yuelai Chen, Lixin Fu, Ning Li, Yonghui Lu, Tongsheng Su, Jianhua Sun, Jie Wang, Zenghui Yue, Wei Zhang, Jiping Zhao, Zhongyu Zhou, Jiani Wu, Kehua Zhou, Yanke Ai, Jing Zhou, Ran Pang, Yang Wang, Zongshi Qin, Shiyan Yan, Hongjiao Li, Lin Luo, Baoyan Liu
Importance: Electroacupuncture involving the lumbosacral region may be effective for women with stress urinary incontinence (SUI), but evidence is limited. Objective: To assess the effect of electroacupuncture vs sham electroacupuncture for women with SUI. Design, Setting, and Participants: Multicenter, randomized clinical trial conducted at 12 hospitals in China and enrolling 504 women with SUI between October 2013 and May 2015, with data collection completed in December 2015...
June 27, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28645869/real-time-changes-in-brain-activity-during-sacral-neuromodulation-for-overactive-bladder
#14
Bradley C Gill, Javier Pizarro-Berdichevsky, Pallab K Bhattacharyya, Thaddeus S Brink, Brian K Marks, Adrienne Quirouet, Sandip P Vasavada, Stephen E Jones, Howard B Goldman
PURPOSE: We performed functional magnetic resonance imaging to identify changes in brain activity during sacral neuromodulation in women with overactive bladder who were responsive to therapy. MATERIALS AND METHODS: Women recruited into the study had nonneurogenic refractory overactive bladder, responded to sacral neuromodulation and had had a stable program for at least 3 months with no subsequent overactive bladder treatment. Enrolled patients completed validated symptom and quality of life instruments before functional magnetic resonance imaging...
June 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28633095/development-and-validation-of-the-polish-version-of-the-urogenital-distress-inventory-short-form-and-the-incontinence-impact-questionnaire-short-form
#15
Katarzyna A Skorupska, Pawel Miotla, Agnieszka Kubik-Komar, Pawel Skorupski, Tomasz Rechberger
OBJECTIVE: The Incontinence Impact Questionnaire (IIQ) measures the impact of urinary incontinence on activities, roles, and emotional states of women, whereas the Urogenital Distress Inventory (UDI) measures how troubling the symptoms are. The aim of this study was to develop and assess the effectiveness of a Polish version of the IIQ and UDI. STUDY DESIGN: The translation into Polish followed standardized procedures. 206 women aged between 31 and 83 years were included into the study...
June 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28627109/high-power-magnetotherapy-a-new-weapon-in-urinary-incontinence
#16
Maria Vadalà, Beniamino Palmieri, Andrea Malagoli, Carmen Laurino
OBJECTIVE: Urinary incontinence (UI) is one of the most common urinary system diseases that mostly affects women but also men. We evaluated the therapeutic efficacy of functional magnetic stimulation (FMS) as potential UI treatment with improvements in the pelvic floor musculature, urodynamic tests and quality of life. METHODS: A total of 20 UI patients (10 females and 10 men, mean age 64, 14 years), including 10 with stress UI, four with urgency UI and six with mixed UI, were treated with FMS (20 min/session) twice a week for 3 weeks...
June 18, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28612999/overactive-bladder-symptom-scores-responsiveness-before-and-after-anticholinergic-treatment-in-women-with-overactive-bladder-the-pilot-study
#17
Suvit Bunyavejchevin
AIM: The aims of this study were: (i) to evaluate change of Overactive Bladder Symptom Scores (OABSS) from before to after solifenacin treatment; and (ii) to evaluate correlation between change of OABSS and 3-day micturition diary, International Prostate Symptom Score (IPSS), and Patient Perception of Bladder Condition (PPBC). METHODS: Thirty-six women, aged > 18 years, diagnosed as having overactive bladder (OAB) at King Chulalongkorn Memorial Hospital, with the symptoms of urgency, frequency with or without urge incontinence for more than 3 months, and at least three episodes of urgency with or without incontinence during the last 3 days prior to the study, were recruited during January 2010-May 2011...
June 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28601565/gait-analysis-of-young-male-patients-diagnosed-with-primary-bladder-neck-obstruction
#18
Matteo Zago, Tommaso Ciro Camerota, Stefano Pisu, Daniela Ciprandi, Chiarella Sforza
Primary bladder neck obstruction (PBNO) represents an inappropriate or inadequate relaxation of the bladder neck during micturition. Based on the observation of an increased rate of postural imbalances in male patients with PBNO, we hypothesized a possible role of an unbalanced biomechanics of the pelvis on urethral sphincters activity. Our aim was to identify kinematic imbalances, usually disregarded in PBNO patients, and which could eventually be involved in the etiopathogenesis of the disease. Seven male adult patients (39...
August 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28587917/home-urodynamic-pressures-and-volume-measurement-for-the-neurogenic-bladder-initial-validation-study
#19
Guy Hidas, Tandis Soltani, John Billimek, Blake Selby, Maryellen S Kelly, Gordon McLorie, Elias Wehbi, Antoine E Khoury
PURPOSE: We evaluated the ability of a bladder pressure/volume diary to identify patients at risk for increased intravesical pressures. MATERIALS AND METHODS: Patients dependent on clean intermittent catheterization used ruler based manometry to measure intravesical pressures before leakage or scheduled drainage at home. We prospectively collected clinical, urodynamic and bladder pressure/volume diary data in patients with spina bifida who were optimized on anticholinergic therapy and clean intermittent catheterization...
June 3, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28560762/low-dose-desmopressin-and-tolterodine-combination-therapy-for-treating-nocturia-in-women-with-overactive-bladder-a-double-blind-randomized-controlled-study
#20
Eric S Rovner, Kyle Raymond, Eugene Andruczyk, Kristian V Juul
OBJECTIVE: Evaluation of safety and efficacy of desmopressin/tolterodine combination therapy in women. METHODS: This double-blind, randomized, proof-of-concept study enrolled 106 patients (≥18 years), with overactive bladder (OAB) and nocturia, with ≥2 nocturnal voids, receiving a 3-month once-daily combination (desmopressin 25 µg, orally-disintegrating tablets [ODT]/tolterodine 4 mg [Detrol® LA]; n = 49) or monotherapy (tolterodine 4 mg/placebo ODT; n = 57)...
May 31, 2017: Lower Urinary Tract Symptoms
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