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https://www.readbyqxmd.com/read/28431196/switch-to-abobotulinum-toxin-a-may-be-useful-in-the-treatment-of-neurogenic-detrusor-overactivity-when-intradetrusor-injections-of-onabotulinum-toxin-a-failed
#1
Florie Bottet, Benoit Peyronnet, Romain Boissier, Bénédicte Reiss, Jean G Previnaire, Andrea Manunta, Jacques Kerdraon, Alain Ruffion, Loïc Lenormand, Brigitte Perrouin Verbe, Sarah Gaillet, Xavier Gamé, Gilles Karsenty
AIMS: To assess the outcomes of switching to a different brand of botulinum toxin A (BTA, from Botox® to Dysport®) in case of failure of intradetrusor injections (IDI) of Botox® in the treatment of neurogenic detrusor overactivity (NDO). METHODS: The charts of all patients who underwent a switch to IDI of Dysport® after failure of an IDI of Botox® at six departments of neurourology were retrospectively reviewed. The main outcomes of interest were the bladder diary data and four urodynamic parameters: maximum cystometric capacity (MCC), maximum detrusor pressure (PDET max), and volume at first uninhibited detrusor contraction (UDC)...
April 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28413135/a-systematic-review-of-the-diagnosis-and-treatment-of-patients-with-neurogenic-hyperactivity-of-the-detrusor-muscle
#2
A Borau, J M Adot, M Allué, S Arlandis, D Castro, M Esteban, J Salinas
BACKGROUND: Neurogenic detrusor hyperactivity (NDH) is a urodynamic observation characterised by involuntary detrusor contractions during the filling phase that are caused by an underlying neurological disease. The common and severe complications that can result from NDH warrant the preparation of healthcare protocols for the proper management of patients with NDH. OBJECTIVE: The aim of this study is to standardise the criteria for the decision-making process in the management of patients with diagnosed or suspected NDH, providing personalised medical care...
April 13, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28407338/tolterodine-er-reduced-increased-bladder-wall-thickness-in-women-with-overactive-bladder-a-randomized-placebo-controlled-double-blind-parallel-group-study
#3
Rhiannon Bray, Rufus Cartwright, Linda Cardozo, Simon Hill, Zhonghong Guan, Vik Khullar
AIMS: We evaluated the effect of Tolterodine extended release (TER) versus placebo on bladder wall thickness (BWT) using transvaginal ultrasound in women with overactive bladder (OAB). MATERIALS AND METHODS: We recruited 79 women with symptoms of OAB with a mean age of 47 years who had a BWT of at least 5 mm and a post-micturition volume of less than 50 mL at screening. Subjects received TER 4 mg or placebo once daily for the first 12 weeks of the study. For the subsequent 12 weeks, all subjects received TER 4 mg once daily...
April 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28370456/predictors-for-detrusor-overactivity-following-extensive-vaginal-pelvic-reconstructive-surgery
#4
Tsia-Shu Lo, Shailaja Nagashu, Wu-Chiao Hsieh, Ma Clarissa Uy-Patrimonio, Lin Yi-Hao
AIM: This study aims to identify the predictors for detrusor overactivity (DO) in women following extensive vaginal pelvic reconstructive surgery (PRS) for advanced pelvic organ prolapse (POP). METHODS: We enrolled 1503 women who had prolapse POP-Q stage ≥ 3 and underwent vaginal PRS with or without MUS from January 2006 to December 2015. All subjects completed a 72-h voiding diary, IIQ-7, UDI-6, POPDI-6, and PISQ-12. Urodynamics (UDS) was performed pre- and post-operatively...
March 31, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28361517/structural-changes-of-the-urinary-bladder-after-chronic-complete-spinal-cord-injury-in-minipigs
#5
Elena E Foditsch, Karin Roider, Irina Patras, Ioan Hutu, Sophina Bauer, Günter Janetschek, Reinhold Zimmermann
PURPOSE: The aim of this study was to determine the structural changes of the urinary bladder after chronic spinal cord injury (SCI) in minipigs with the primary focus on the analysis of urinary bladder wall proteins and their quantitative distribution. METHODS: Seven Göttingen minipigs (adult, female) underwent a complete spinal cord transection. Follow-up time was 4 months during which the bladder was drained by frequent single catheterisation and data from the bladder diary and daily urine strip test were collected...
March 24, 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28361514/treatment-of-stress-urinary-incontinence-in-neurological-patients-with-an-injectable-elastomer-prosthesis-preliminary-results
#6
Julien Renard, Marco Citeri, Lucia Zanollo, Chiara Guerrer, Luigi Rizzato, Luca Frediani, Christophe Iselin, Michele Spinelli
Many treatment options for stress urinary incontinence are difficult to apply to neurological patients. Urolastic is a new agent that is primarily indicated for women with mild stress urinary incontinence or men after prostate surgery. In this report, we present a series of 5 cases describing the first use of Urolastic to treat neurological patients. All patients were evaluated with a voiding diary and the use of auxiliary devices as the main indicators of continence. The median operative time was 30.8 minutes, and no complications were observed...
March 24, 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28360952/urogynecological-conditions-associated-with-overactive-bladder-symptoms-in-women
#7
James C Forde, Jonathan L Davila, Brian K Marks, Matthew Epstein, Johnson F Tsui, Jeffrey P Weiss, Jerry G Blaivas
INTRODUCTION: Overactive bladder symptoms (OAB) affect 9-43% of women and are associated with underlying disorders, including pelvic organ prolapse (POP) and stress urinary incontinence (SUI). The aim of this study is to identify urogynecological conditions associated with OAB symptoms. METHODS: This prospective, institutional review board-approved study included women referred to a tertiary centre with lower urinary tract symptoms (LUTS). All women completed the self-administered OAB questionnaire (OABSS)...
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28355584/ambulatory-urodynamic-monitoring-of-women-with-overactive-bladder-syndrome-during-single-voiding-cycle
#8
Fulya Dokmeci, S Esra Cetinkaya, M Murat Seval, Omer Dai
OBJECTIVE(S): To present data of standardized ambulatory urodynamic monitoring (AUM) performed in women with overactive bladder syndrome (OAB) and to evaluate the relevance of AUM data with clinical findings of the patients. STUDY DESIGN: Records of women with symptoms of OAB were retrospectively reviewed (n=249). Of women fulfilling the Overactive Bladder Awareness Tool (OAB-V8) with a score ≥8 and the 3-day voiding diary (VD) with a frequency >7/day (n=167), those who underwent urodynamic investigation were selected (n=76)...
March 18, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28345779/sacral-neuromodulation-for-detrusor-hyperactivity-with-impaired-contractility
#9
Derek B Hennessey, Nathan Hoag, Johan Gani
INTRODUCTION: Detrusor hyperactivity with impaired contractility (DHIC) is a challenging condition to manage. Sacral neuromodulation (SNM) is a proven treatment modality for both the individual aspects of DHIC. To date, data reporting the outcome of SNM for DHIC are lacking. MATERIALS AND METHODS: Consecutive patients undergoing SNM for DHIC were followed prospectively, from April 2013 to October 2016. Patient demographics, bladder diaries, subjective response rates, ICIQ-OAB, and PGI-I scores were recorded...
March 27, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28270954/the-attitudes-of-urologists-and-gynecologists-about-overactive-bladder-and-treatment-of-it-in-turkey-a-questionnaire-survey
#10
Burhan Coşkun, Ömer Bayrak, Murat Dinçer, Kadir Önem, Cenk Gürbüz, Rahmi Onur
OBJECTIVE: We aimed to review the approaches of urologist and gynecologist in the management of overactive bladder (OAB). MATERIAL AND METHODS: A questionnaire consisting of 12 items were answered by 375 urologist and 46 gynecologist. The differences between frequency of encountering OAB, their viewpoints concerning conservative treatment, and their experience related to anticholinergic drug use and the management of refractory OAB were compared. RESULTS: The majority of the urologists, and gynecologists responded to the question "How often do you encounter OAB patients in your daily practice?" as 'in 10-25, and 50% of our patients', respectively (<0...
March 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28268078/comparative-study-of-the-b-saq-oab-v8-and-oab-v3-questionnaires-as-screening-tools-for-overactive-bladders-in-clinical-practice
#11
J C Angulo, M P Calderín, Y Fernández, M González, E Gómez, M B Herreros, P Peñasco, M Zapatero, J F Dorado
OBJECTIVE: To compare the capacity shown by 3 self-assessment questionnaires validated in Spanish (B-SAQ, OAB-V8 and OAB-V3) for the screening of patients with overactive bladder (OAB) in clinical practice. MATERIAL AND METHOD: A noninterventional observational study was conducted of men and women older than 30 years evaluated in primary care consultations. The clinical diagnosis of OAB was conducted through a case history review, physical examination, urine analysis, ultrasonography and voiding diary...
March 3, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28261680/long-term-adherence-to-antimuscarinic-drugs-when-treating-overactive-bladder-in-the-older-subjective-reason-and-objective-factors
#12
Kirill Vladimirovich Kosilov, Sergay Alexandrovich Loparev, Irina Gennadyevna Kuzina, Boris Izrailevich Geltser, Olga Viktorovna Shakirova, Natalya Sergeevna Zhuravskaya, Alexandra Lobodenko
PURPOSE: Comparison of subjective reasons for the refusal of antimuscarinic treatment and the state of objective economic, social, psychological and health status markers in the elderly with overactive bladder. MATERIALS AND METHODS: One thousand seven hundred thirty-six (1,736) patients participated in the experiment: 1,036 or 59.7% of women, and 700 or 40.3% of men aged over 60 years (average age, 68.1 years) who took antimuscarinic (AM) drugs during the year...
March 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28252310/-degree-of-satisfaction-of-patients-continuing-overactive-bladder-treatment-with-mirabegron
#13
K Švabík, J Mašata, J Krhut, R Zachoval, T Hanuš, M Halaška, L Horčička, L Krofta, M Hanáková, A Martan
OBJECTIVE: Overactive bladder syndrome is chronic disease with high prevalence rate (9-42%). This syndrome requires long term therapy, but the treatment persistence is after 3 months over all 26% with further decline in one-year period as low as 18.5%. Main reasons for stopping the treatment are low efficacy, the medication didnt work as expected and side effects. How much satisfied are patients with mirabegron persisting on its treatment? To answer this question, we provided secondary analysis of multicentre follow-up study of patients on mirabegron...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28248418/defeating-urinary-incontinence-with-exercise-training-results-of-a-pilot-study-in-frail-older-women
#14
Kristine M C Talley, Jean F Wyman, Ulf Bronas, Becky J Olson-Kellogg, Teresa C McCarthy
OBJECTIVES: To determine whether combining behavioral urinary incontinence (UI) treatments with physical activity improves UI in frail older women. DESIGN: Single-blind, two-arm pilot randomized controlled trial. SETTING: Senior apartments. PARTICIPANTS: Frail women (mean age 84.9 ± 6.4) without dementia (n = 42). INTERVENTION: Twelve-week program of customized behavioral UI treatments: 150 minutes of weekly walking and twice weekly strength training classes...
March 1, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28247649/-validation-of-urgency-scale-to-detect-and-assess-urgency-in-patients-with-overactive-bladder
#15
G G Krivoborodov, E I Tur
INTRODUCTION: Urinary urgency is a hallmark symptom of overactive bladder (OAB). Several scales have been used to measure urgency. Taking into account the exceptional importance of these scales, it is important to determine their reliability, which depends directly on the accuracy of the wording and clarity to patients. AIM: To determine reliability of Russian-language translation of the Patient Perception of Intensity of Urgency Scale (PPIUS) in identifying and assessing urgency in patients with OAB...
April 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28222537/timing-and-kinetics-of-nonmotor-fluctuations-in-advanced-parkinson-s-disease
#16
Christiana Ossig, Daniel Sippel, Mareike Fauser, Florin Gandor, Wolfgang H Jost, Georg Ebersbach, Alexander Storch
BACKGROUND: Nonmotor symptoms (NMS) are known to fluctuate together with motor oscillations in advanced PD, but their timing and kinetics remains enigmatic. OBJECTIVE: To evaluate timing and kinetics of NMS fluctuations. METHODS: Analysis of diary data from 17 fluctuating PD patients. Diaries were completed by rating NMS as absent (defined herein as NMS On state) or present (NMS Off state) and motor function for every hour for 5 consecutive days...
February 8, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28202358/a-prospective-multicenter-double-blind-randomized-trial-of-bladder-instillation-of-liposome-formulation-onabotulinumtoxina-for-interstitial-cystitis-bladder-pain-syndrome
#17
Yao-Chi Chuang, Hann-Chorng Kuo
BACKGROUND: Intravesical instillation of liposomal-formulated botulinum toxin A (lipotoxin) has shown therapeutic effects on treatment of refractory overactive bladder without needle injections. We hereby assessed lipotoxin for the treatment of refractory interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS: This two-center, double-blind, randomized, placebo-controlled physician-initiated study enrolled patients with refractory IC/BPS. The patients were assigned to intravesical instillation of lipotoxin (onabotulinumtoxinA 200 U with 80mg sphingomyelin) (n=31), onabotulinumtoxinA 200 U in normal saline (n=28), or normal saline alone (n=31)...
February 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28195356/efficacy-of-onabotulinum-toxin-a-injection-in-pediatric-patients-with-non-neurogenic-detrusor-overactivity
#18
Omer Bayrak, Erkan Sadioglu, Haluk Sen, Kazim Dogan, Sakip Erturhan, Ilker Seckiner
AIMS: To evaluate the effectiveness and reliability of onabotulinum toxin A (onaBoNT-A) injections in pediatric patients with non-neurogenic detrusor overactivity (NNDO). METHODS: Between January 2010 and February 2016, 39 patients underwent onaBoNT-A injections for NNDO, and were evaluated retrospectively. Three-day voiding diary was filled at baseline, and at the postoperative 9th month. The voiding frequency, incontinence episodes, and the cystometric capacity were noted...
February 14, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28150436/efficacy-and-safety-of-gabapentin-in-comparison-to-solifenacin-succinate-in-adult-overactive-bladder-treatment
#19
Michael E Chua, Manuel C See, Ednalyn B Esmeňa, Jaime C Balingit, Marcelino L Morales
OBJECTIVE: To evaluate the efficacy and safety of gabapentin in comparison to solifenacin succinate and placebo for the treatment of adult patients with overactive bladder (OAB). METHOD: A 12-week, randomized, double-blind, double dummy placebo-controlled, clinical trial was conducted between October 2010 and August 2014 at a tertiary medical center. Eligible and consenting patients included were randomized into three treatment groups (placebo, gabapentin and solifenacin)...
February 2, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28120446/phase-iii-study-to-assess-long-term-52-week-safety-and-efficacy-of-mirabegron-a-%C3%AE-3-adrenoceptor-agonist-in-japanese-patients-with-overactive-bladder
#20
Osamu Yamaguchi, Yasushi Ikeda, Sumito Ohkawa
OBJECTIVES: To investigate safety, tolerability and efficacy of long-term (52 weeks) open-label treatment with mirabegron 50 mg, with an optional dose increase to 100 mg, in patients with overactive bladder (OAB). METHODS: Patients received mirabegron 50 mg once daily for 52 weeks. If efficacy was insufficient at week 8, the dose could be increased to 100 mg. Safety was evaluated based on vital signs, adverse events (AEs), laboratory findings, electrocardiogram and post-void residual volume...
January 2017: Lower Urinary Tract Symptoms
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