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https://www.readbyqxmd.com/read/29767479/nocturia-is-more-bothersome-than-daytime-luts-results-from-an-observational-real-life-practice-database-including-8659-european-and-american-luts-patients
#1
Karel Everaert, Peter Anderson, Robert Wood, Fredrik L Andersson, Tove Holm-Larsen
PURPOSE: Lower urinary tract symptoms (LUTS) encompass several diagnoses, including overactive bladder (OAB) and benign prostatic hyperplasia (BPH). Nocturia is a standalone symptom, but also included in OAB and BPH. Current discussion addresses whether the overlap of the diagnoses is too broad, leading to misdiagnosis. This study explored the differences in level, causes and consequences for patients with a diagnosis of daytime LUTS compared with a diagnosis of nocturia, and discussed whether people are being treated for the symptoms that truly bother them the most...
May 16, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29753213/onabotulinumtoxina-detrusor-injection-improves-female-sexual-function-in-women-with-overactive-bladder-wet-syndrome
#2
Matteo Balzarro, Emanuele Rubilotta, Andrea Braga, Silvia Bassi, Tania Processali, Walter Artibani, Maurizio Serati
OBJECTIVES: The correlation between changes in sexual function and improvements in LUTD in patients treated with OnabotulinumtoxinA (onaBoNT-A) detrusor injection is unclear and limited only to women with neurogenic OAB. The aim of this study was to evaluate the impact of OnabotulinumtoxinA (onaBoNT-A) injection on sexual function in women undergoing this treatment for idiopathic wet overactive bladder (OAB). STUDY DESIGN: This is a pilot three-center observational study including women affected by idiopathic wet overactive bladder refractory to standard conservative treatments and underwent onaBoNT-A injection...
May 5, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29752971/metabolomic-analysis-of-overactive-bladder-in-male-patients-identification-of-potential-metabolite-biomarkers
#3
Hiroshi Shimura, Takahiko Mitsui, Satoru Kira, Tatsuya Ihara, Norifumi Sawada, Hiroshi Nakagomi, Tatsuya Miyamoto, Sachiko Tsuchiya, Mie Kanda, Masayuki Takeda
OBJECTIVES: To identify metabolites that are associated with an overactive bladder (OAB) using metabolomics. PATIENTS AND METHODS: A total of 58 males without apparent neurological disease completed 24-hr bladder diaries of their micturition behavior and International Prostate Symptom Score (IPSS) for the assessment of micturition behavior and lower urinary tract symptoms. Urgency was defined as an IPSS urgency score of ≥2 (OAB group), and patients with IPSS urgency scores of ≤1 belonged to the control group...
May 9, 2018: Urology
https://www.readbyqxmd.com/read/29704486/identification-of-experimental-bladder-sensitivity-among-dysmenorrhea-sufferers
#4
Kevin M Hellman, Avisek Datta, Nicole D Steiner, Julia N Kane Morlock, Ellen F Garrison, Daniel J Clauw, Frank F Tu
BACKGROUND: Dysmenorrhea is a common risk factor for chronic pain conditions including bladder pain syndrome. Few studies have formally evaluated asymptomatic bladder pain sensitivity in dysmenorrhea, and whether this largely reflects excess pelvic symptom reporting due to comorbid psychological dysfunction. OBJECTIVE: We sought to determine whether bladder hypersensitivity is more common among women reporting moderate or greater dysmenorrhea, without chronic pain elsewhere, after accounting for anxiety and depression...
April 25, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29697936/do-uroflowmetry-and-post-void-residual-urine-tests-necessary-in-children-with-primary-nocturnal-enuresis
#5
Shang-Jen Chang, Stephen Shei-Dei Yang
OBJECTIVES: To examine the benefits of repetitive uroflowmetry and post void residual urine (PVR) tests in children with primary nocturnal enuresis (PNE). MATERIAL AND METHODS: Children aged ≥6 years with PNE who visited our clinics for management of enuresis were included for study. Patients were requested to complete a questionnaire including baseline characteristics and Dysfunctional Voiding Symptom Score (DVSS), 2-day bladder diary, and Rome III criteria for constipation...
March 15, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29672306/effects-of-bladder-training-and-pelvic-floor-muscle-training-in-female-patients-with-overactive-bladder-syndrome-a-randomized-controlled-trial
#6
Raheela Mohsin Rizvi, Novera Ghayoor Chughtai, Naheed Kapadia
OBJECTIVE: The purpose of our study was to see the efficacy of 3 different modes of treatment for overactive bladder (OAB) in symptoms reduction and quality of life improvement. METHODS: We conducted a 12-week single-blinded randomized controlled trial of women aged 22-65 years with clinical diagnosis of OAB. Arm A (n = 47) received bladder training, arm B (n = 50) received pelvic floor muscle training (PFMT), and arm C (n = 50) received PFMT with biofeedback. Bladder diary was used to assess the difference in urinary frequency, urgency, and leak accidents before and after treatment...
April 19, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29651695/factors-influencing-efficacy-endpoints-in-clinical-trials-for-new-oral-medicinal-treatments-for-overactive-bladder-a-systematic-literature-review-and-meta-analysis
#7
Shingo Iino, Masayuki Kaneko, Mamoru Narukawa
PURPOSE: Overactive bladder (OAB) is a symptom-based disease; therefore, clinical trials to evaluate treatments for OAB employ a range of efficacy endpoints. Since factors that influence efficacy endpoints can affect trial outcomes, their identification could aid in the design of future OAB clinical trials. We investigated factors influencing different efficacy endpoints used in clinical trials with OAB patients and examined their characteristics to determine future clinical trial strategies for new medicinal treatments for OAB...
April 12, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29609421/clinical-efficacy-of-solifenacin-in-the-management-of-diabetes-mellitus-associated-versus-idiopathic-overactive-bladder-symptoms-a-multicenter-prospective-study
#8
Hoon Choi, Jae Hyun Bae, Cheol Young Oh, Seong Jin Jeong, Woo Jin Ko, Jong Bo Choi, Ju Tae Seo, Dong Hwan Lee, Joon Chul Kim, Kwang Woo Lee, Young Ho Kim
PURPOSE: To compare the clinical efficacy of anticholinergics for managing diabetes mellitus-associated overactive bladder (DM OAB) versus idiopathic overactive bladder (OAB) in Korean women. METHODS: We conducted a multicenter, prospective, parallel-group, open-label, 12-week study. Women (20-65 years old) with OAB symptoms for over 3 months were assigned to the DM OAB and idiopathic OAB groups. Changes in the Overactive Bladder Symptom Score (OABSS), urgency, urinary urgency incontinence, nocturia, daytime frequency according to a voiding diary, uroflowmetry, and postvoid residual urine volume (PVR) at the first visit (V1), week 4 (V2), and week 12 (V3) were compared...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29609420/efficacy-of-an-alpha-blocker-for-the-treatment-of-nonneurogenic-voiding-dysfunction-in-women-an-8-week-randomized-double-blind-placebo-controlled-trial
#9
Young-Suk Lee, Kyu-Sung Lee, Myung-Soo Choo, Joon Chul Kim, Jeong Gu Lee, Ju Tae Seo, Jeong Zoo Lee, Ji Youl Lee, Seung-June Oh, Yong Gil Na
PURPOSE: To evaluate the efficacy of an alpha-1 adrenergic receptor (α1-AR) blocker for the treatment of female voiding dysfunction (FVD) through a pressure-flow study. METHODS: This was a randomized, double-blind, placebo-controlled trial. Women aged ≥18 years with voiding symptoms, as defined by an American Urological Association symptom score (AUA-SS) ≥15 and a maximum flow rate (Qmax) <15 mL/sec with a voided volume of >100 mL and/or a postvoid residual (PVR) volume >150 mL, were randomly allocated to either the alfuzosin or placebo group...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29532309/does-sex-matter-a-matched-pairs-analysis-of-neuromodulation-outcomes-in-women-and-men
#10
Laura N Nguyen, Jamie Bartley, Kim A Killinger, Priyanka Gupta, John Lavin, Ayad Khourdaji, Jason Gilleran, Natalie Gaines, Judith A Boura, Kenneth M Peters
AIMS: To evaluate whether baseline symptoms and outcomes are influenced by gender in a matched cohort undergoing neuromodulation. METHODS: Patients in our prospective neuromodulation database that had a tined lead placed were reviewed. Those that had implantable pulse generator (IPG) placed were matched on age and urologic diagnosis. History, voiding diaries, satisfaction, Interstitial Cystitis Symptom/Problem Index (ICSIPI), and overactive bladder symptom severity (OABq ss)/health-related quality of life (HRQOL) preimplant and over 3 years were evaluated using descriptive statistics, repeated measures, and matched pair GEE or mixed analyses...
March 13, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29512808/urethral-funneling-visualized-during-pelvic-floor-sonography-analysis-of-occurrence-among-urogynecological-patients
#11
Edyta Wlaźlak, Tomasz Kluz, Grzegorz Surkont, Jacek Kociszewski
OBJECTIVES: There are different diagnostic methods used in women with urinary incontinence symptoms such as: medical history, voiding diary, cough test, pad test, urodynamic testing. None of them is optimal. The aim of this study is to analyze the correlation between urethral funneling visualized during pelvic floor sonography and symptoms of stress urinary incontinence. MATERIAL AND METHODS: We have performed a retrospective analysis of 657 complete datasets of patients who attended our urogynecological clinic for diagnostics...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29473382/a-randomized-multicenter-controlled-study-comparing-efficacy-and-safety-of-a-new-complementary-and-alternative-medicine-cam-versus-solifenacin-succinate-in-women-with-overactive-bladder-syndrome
#12
Carlo Vecchioli-Scaldazza, Carolina Morosetti, Serena Maruccia, Stefano Casellato, Wilma Rociola, Ester Illiano, Francesco Garofalo
INTRODUCTION: To assess efficacy and tolerability of a new complementary and alternative medicine (CAM) consisting of vitamins (C and D), herbal products (cucurbita maxima, capsicum annum, polygonum capsicatum) and amino acid L-Glutammina, in the treatment of female Overactive Bladder syndrome (OAB). MATERIALS AND METHODS: 90 consecutive women with OAB symptoms were enrolled in this prospective, randomized, controlled study. Women were divided randomly into two groups of 45 patients each...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29467024/male-synthetic-sling-versus-artificial-urinary-sphincter-trial-for-men-with-urodynamic-stress-incontinence-after-prostate-surgery-master-study-protocol-for-a-randomised-controlled-trial
#13
Lynda Constable, Nikki Cotterill, David Cooper, Cathryn Glazener, Marcus J Drake, Mark Forrest, Chris Harding, Mary Kilonzo, Graeme MacLennan, Kirsty McCormack, Alison McDonald, Anthony Mundy, John Norrie, Robert Pickard, Craig Ramsay, Rebecca Smith, Samantha Wileman, Paul Abrams
BACKGROUND: Stress urinary incontinence (SUI) is a frequent adverse effect for men undergoing prostate surgery. A large proportion (around 8% after radical prostatectomy and 2% after transurethral resection of prostate (TURP)) are left with severe disabling incontinence which adversely effects their quality of life and many are reliant on containment measures such as pads (27% and 6% respectively). Surgery is currently the only option for active management of the problem. The overwhelming majority of surgeries for persistent bothersome SUI involve artificial urinary sphincter (AUS) insertion...
February 21, 2018: Trials
https://www.readbyqxmd.com/read/29464764/a-pilot-feasibility-study-of-treating-overactive-bladder-patients-with-percutaneous-saphenous-nerve-stimulation
#14
Scott A MacDiarmid, M Sasha John, Paul B Yoo
AIMS: Effective long-term treatment of overactive bladder (OAB) remains a significant clinical challenge. We present our initial experience with a new bladder neuromodulation method that electrically targets the saphenous nerve (SAFN). METHODS: A total of 18 OAB patients (female, 55-84 years) were provided with percutaneous SAFN stimulation. The SAFN was targeted with a needle electrode inserted below the medial condyle of the tibia. Activation of the SAFN was confirmed by the patient's perception of paresthesia radiating down the leg...
February 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29463148/overactive-bladder-syndrome-treatment-with-ospemifene-in-menopausal-patients-with-vulvovaginal-atrophy-improvement-of-sexuality
#15
Michele Carlo Schiavi, Valentina Sciuga, Andrea Giannini, Flaminia Vena, Ottavia D'oria, Giovanni Prata, Chiara Di Tucci, Delia Savone, Natalia Aleksa, Carmela Capone, Daniele Di Mascio, Maria Letizia Meggiorini, Marco Monti, Marzio Angelo Zullo, Ludovico Muzii, Pierluigi Benedetti Panici
The aim of this study was to assess the effectiveness of ospemifene in the improvement of sexual function in postmenopausal women with vulvovaginal atrophy (VVA) affected by overactive bladder syndrome (OAB) or urge urinary incontinence (UUI). One hundred five postmenopausal patients with VVA affected by OAB and/or UUI were enrolled for the study. All patients received ospemifene 60 mg for 12 weeks. Clinical examination, 3-d voiding diary and the vaginal health index (VHI) were performed at baseline and at 12 weeks...
February 20, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29434675/best-practice-in-the-management-of-storage-symptoms-in-male-lower-urinary-tract-symptoms-a-review-of-the-evidence-base
#16
REVIEW
Mauro Gacci, Arcangelo Sebastianelli, Pietro Spatafora, Giovanni Corona, Sergio Serni, Dirk De Ridder, Stavros Gravas, Paul Abrams
Storage lower urinary tract symptoms (LUTS) are characterized by an altered bladder sensation, increased daytime frequency, nocturia, urgency and urgency incontinence. Some evidence underlines the role of metabolic factors, pelvic ischemia, prostatic chronic inflammation and associated comorbidities in the pathophysiology of storage LUTS. A detailed evaluation of the severity of storage LUTS, and the concomitance of these symptoms with voiding and postmicturition symptoms, is mandatory for improving the diagnosis and personalizing treatment...
February 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29432226/combination-treatment-for-male-lower-urinary-tract-symptoms-with-anticholinergic-and-alpha-blockers
#17
Alex Gomelsky, Emily F Kelly, David C Dalton
PURPOSE OF REVIEW: Although alpha-adrenergic antagonists (α-blockers) are effective for relieving voiding lower urinary tract symptoms (LUTS) in men, storage symptoms often persist. The aim of this manuscript is to evaluate the efficacy and safety of combination therapy with α-blockers and muscarinic receptor antagonists (anticholinergics). RECENT FINDINGS: High-quality evidence confirms that the addition of an anticholinergic improves micturition diary parameters, such as daytime and nocturnal frequency and urgency incontinence episodes, as well as total and storage subset scores on the International Prostate Symptom Score...
May 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29398096/medical-treatment-of-female-overactive-bladder-syndrome-and-treatment-related-effects
#18
REVIEW
Sheng-Mou Hsiao, Ho-Hsiung Lin
The age-adjusted prevalence of overactive bladder syndrome (OAB) in Taiwan is approximately 16.9%. Currently, a variety of treatments are available for female OAB. However, different treatments have different treatment-related effects that may lead to significant adverse effects and ineffective treatment. In this article, we reviewed the tools that can be used to evaluate the efficacy of OAB treatments, such as a variety of questionnaires, serum or urine biomarkers, bladder diaries and urodynamic studies. In addition, we reviewed the medications used for female OAB treatment, such as antimuscarinics, beta-3 agonists, onabotulinumtoxinA intradetrusor injections, topical vaginal estrogen therapy and bladder instillation of liposome-encapsulated onabotulinumtoxinA...
February 1, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29385787/differences-in-urodynamic-parameters-according-to-the-presence-of-a-hunner-lesion-in-women-with-interstitial-cystitis-bladder-pain-syndrome
#19
Sun Tae Ahn, Hyeong Guk Jeong, Tae Yong Park, Jong Wook Kim, Hong Seok Park, Du Geon Moon, Jeong Gu Lee, Mi Mi Oh
PURPOSE: Differences in the severity of subjective symptoms have been noted depending on whether a Hunner lesion is present in women with interstitial cystitis/bladder pain syndrome (IC/BPS). In this study, we aimed to identify differences in objective urodynamic parameters in women with IC/BPS according to the presence of a Hunner lesion. METHODS: This cross-sectional study included a total of 55 patients with IC/BPS. IC/BPS and the presence of a Hunner lesion on cystoscopy were diagnosed according to American Urological Association guidelines...
January 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29383032/comparison-of-objective-and-subjective-factors-in-the-adherence-to-antimuscarinics-when-treating-overactive-bladder-in-employed-persons
#20
Kirill Vladimirovich Kosilov, Sergey Loparev, Irina Kuzina, Alexandra Prokofyeva
Background: This study examines subjective reasons for the refusal of treatment and the state of objective status markers of various factors influencing the resistance of patients when treating overactive bladder by antimuscarinic drugs (AMs). Methods: The socioeconomic and medical parameters were studied in 2465 patients aged 18-60 years (1446 women (58.7%), 1019 men (41.3%); mean age was 52.1) taking AMs during the year. The study control was carried out by studying passport data, employers' income certificates, patients' ambulatory medical records, the use of OABq-SF and MOS SF-36 questionnaires, voiding diaries and uroflowmetry...
December 2017: Therapeutic Advances in Urology
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