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https://www.readbyqxmd.com/read/29467518/is-umbilical-coiling-genetically-determined
#1
Nina K Ayala, Linda M Ernst, Emily S Miller
OBJECTIVE: Abnormal umbilical cord coiling is associated with adverse perinatal outcomes; however, the etiology of the umbilical coiling pattern is poorly understood. STUDY DESIGN: Retrospective cohort of all twin deliveries >20 weeks in 2014. Pregnancies were dichotomized by chorionicity and the umbilical coiling index (UCI) and placental cord insertion location were compared. In cases with one or both cords hypercoiled, the direction and pattern of coiling were compared by chorionicity...
February 21, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29467082/national-survey-on-airway-and-difficult-airway-management-in-intensive-care-units
#2
M G Gómez-Prieto, M R Míguez-Crespo, J R Jiménez-Del-Valle, M D González-Caro, I Marmesat-Ríos, J Garnacho-Montero
OBJECTIVE: To know organization, management and training in airway (AW) in Spanish Intensive Care Units (ICUs), with special interest in difficult airway (DAW). DESIGN: Descriptive cross-sectional study and χ2 subanalysis, conducted through a national survey from november 1th to december 15th, 2016. With the SEMICYUC's support, an online questionnaire of 27 items was sent to 179 ICUs. SETTING: ICUs of public, private centers, and consortia...
February 18, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29426705/is-a-project-needed-to-prevent-urinary-tract-infection-in-patients-admitted-to-spanish-icus
#3
F Álvarez Lerma, P Olaechea Astigarraga, X Nuvials, R Gimeno, M Catalán, M P Gracia Arnillas, I Seijas Betolaza, M Palomar Martínez
OBJECTIVE: To analyze epidemiological data of catheter-associated urinary tract infection (CAUTI) in critically ill patients admitted to Spanish ICUs in order to assess the need of implementing a nationwide intervention program to reduce these infections. DESIGN: Non-intervention retrospective annual period prevalence analysis. SETTING: Participating ICUs in the ENVIN-UCI multicenter registry between the years 2007-2016. PATIENTS: Critically ill patients admitted to the ICU with catheter-associated urinary tract infection (CAUTI)...
February 6, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29422129/nearest-clusters-based-partial-least-squares-discriminant-analysis-for-the-classification-of-spectral-data
#4
Weiran Song, Hui Wang, Paul Maguire, Omar Nibouche
Partial Least Squares Discriminant Analysis (PLS-DA) is one of the most effective multivariate analysis methods for spectral data analysis, which extracts latent variables and uses them to predict responses. In particular, it is an effective method for handling high-dimensional and collinear spectral data. However, PLS-DA does not explicitly address data multimodality, i.e., within-class multimodal distribution of data. In this paper, we present a novel method termed nearest clusters based PLS-DA (NCPLS-DA) for addressing the multimodality and nonlinearity issues explicitly and improving the performance of PLS-DA on spectral data classification...
June 7, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29415263/scepath-energy-landscape-based-inference-of-transition-probabilities-and-cellular-trajectories-from-single-cell-transcriptomic-data
#5
Suoqin Jin, Adam L MacLean, Tao Peng, Qing Nie
Motivation: Single-cell RNA-sequencing (scRNA-seq) offers unprecedented resolution for studying cellular decision-making processes. Robust inference of cell state transition paths and probabilities is an important yet challenging step in the analysis of these data. Results: Here we present scEpath, an algorithm that calculates energy landscapes and probabilistic directed graphs in order to reconstruct developmental trajectories. We quantify the energy landscape using "single-cell energy" and distance-based measures, and find that the combination of these enables robust inference of the transition probabilities and lineage relationships between cell states...
February 5, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29393146/correlation-of-fecal-markers-with-magnifying-endoscopic-stratification-in-patients-with-ulcerative-colitis-who-are-in-clinical-remission
#6
Shoichiro Mine, Fuminao Takeshima, Yuko Akazawa, Kayoko Matsushima, Hitomi Minami, Naoyuki Yamaguchi, Ken Ohnita, Hajime Isomoto, Kazuhiko Nakao
BACKGROUND: Maintenance of mucosal healing is recommended during the treatment of ulcerative colitis (UC). However, symptoms of UC often do not reflect mucosal disease activity. Fecal markers such as calprotectin, lactoferrin, and hemoglobin have been reported to correlate well with the Mayo endoscopic subscore (MES) and are being considered alternative monitoring tools in endoscopy. Ulcerative Colitis Endoscopic Index of Severity (UCEIS) is a new and more detailed endoscopic scoring system compared to MES...
February 1, 2018: Digestion
https://www.readbyqxmd.com/read/29339385/effectiveness-of-an-antimicrobial-stewardship-program-in-critical-care-a-before-and-after-study
#7
Francisco Álvarez-Lerma, Santiago Grau Cerrato, Daniel Echeverría Esnal, Montserrat Martínez-Alonso, Maria Pilar Gracia Arnillas, Juan Pablo Horcajada, Juan Ramón Masclans
We evaluated the use of antimicrobials expressed as defined daily doses (DDDs) per 1,000 patient days and days of therapy (DOT) per 100 occupied bed-days in a intensive care unit (UCI) of a general hospital in Barcelona, Spain, before and after implementation of an antimicrobial stewardship (AMS) program (2007-2010 versus 2011-2015). The quarterly costs of antimicrobials used in the ICU and its weight in the overall hospital costs of antimicrobials were calculated. The effect of the applied AMS program on DDDs and DOT time series data was analyzed by means of intervention time series analysis...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29336790/a-multiple-kernel-classification-approach-based-on-a-quadratic-successive-geometric-segmentation-methodology-with-a-fault-diagnosis-case
#8
Leonardo M Honório, Daniele A Barbosa, Edimar J Oliveira, Paulo A Nepomuceno Garcia, Murillo F Santos
This work presents a new approach for solving classification and learning problems. The Successive Geometric Segmentation technique is applied to encapsulate large datasets by using a series of Oriented Bounding Hyper Box (OBHBs). Each OBHB is obtained through linear separation analysis and each one represents a specific region in a pattern's solution space. Also, each OBHB can be seen as a data abstraction layer and be considered as an individual Kernel. Thus, it is possible by applying a quadratic discriminant function, to assemble a set of nonlinear surfaces separating each desirable pattern...
January 11, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29320180/inner-and-outer-recursive-neural-networks-for-chemoinformatics-applications
#9
Gregor Urban, Niranjan Subrahmanya, Pierre Baldi
Deep learning methods applied to problems in chemoinformatics often require the use of recursive neural networks to handle data with graphical structure and variable size. We present a useful classification of recursive neural networks approaches into two classes, the Inner and Outer approach. The inner approach uses recursion inside the underlying graph, to essentially 'crawl' the edges of the graph, while the outer approach uses recursion outside the underlying graph, to aggregate information over progressively longer distances in an orthogonal direction...
January 10, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29245686/a-new-caryophyllaceae-feeding-species-of-i-macrosiphum-i-hemiptera-aphididae-in-republic-of-georgia-and-a-redescription-of-i-macrosiphum-i-i-hartigi-i-hille-ris-lambers
#10
Shalva Barjadze, Sebastiano Barbagallo, Roger Blackman, Işil Özdemir
Apterous and alate viviparous females and the alate males of Macrosiphum eastopi Barjadze & Blackman sp. n. living on Oberna multifida Ikonn. (=Silene multifida Rohrb.) (Caryophyllaceae) are described from the Republic of Georgia (Caucasus). Type specimens are deposited at the Institute of Zoology, Ilia State University (IZISU), Tbilisi, Georgia; the Natural History Museum (BMNH), London, U.K.; and the University of Catania (UCI), Sicily, Italy. Apterous and alate viviparous females of its close relative M...
October 31, 2017: Zootaxa
https://www.readbyqxmd.com/read/29244988/chemotherapy-use-at-the-end-of-life-in-uganda
#11
Daniel Low, Emily C Merkel, Manoj Menon, Gary H Lyman, Henry Ddungu, Elizabeth Namukwaya, Mhoira Leng, Corey Casper
Purpose Avoiding chemotherapy during the last 30 days of life has become a goal of cancer care in the United States and Europe, yet end-of-life chemotherapy administration remains a common practice worldwide. The purpose of this study was to determine the frequency of and factors predicting end-of-life chemotherapy administration in Uganda. Methods Retrospective chart review and surveys and interviews of providers were performed at the Uganda Cancer Institute (UCI), the only comprehensive cancer center in the area, which serves a catchment area of greater than 100 million people...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29238152/a-novel-sequence-space-related-to-formula-see-text-defined-by-orlicz-function-with-application-in-pattern-recognition
#12
Mohd Shoaib Khan, Qm Danish Lohani
In the field of pattern recognition, clustering groups the data into different clusters on the basis of similarity among them. Many a time, the similarity level between data points is derived through a distance measure; so, a number of clustering techniques reliant on such a measure are developed. Clustering algorithms are modified by employing an appropriate distance measure due to the high versatility of a data set. The distance measure becomes appropriate in clustering algorithm if weights assigned at the components of the distance measure are in concurrence to the problem...
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/29228175/sana-netgo-a-combinatorial-approach-to-using-gene-ontology-go-terms-to-score-network-alignments
#13
Wayne B Hayes, Nil Mamano
Motivation: Gene Ontology (GO) terms are frequently used to score alignments between protein-protein interaction (PPI) networks. Methods exist to measure GO similarity between proteins in isolation, but proteins in a network alignment are not isolated: each pairing is dependent on every other via the alignment itself. Existing measures fail to take into account the frequency of GO terms across networks, instead imposing arbitrary rules on when to allow GO terms. Results: Here we develop NetGO, a new measure that naturally weighs infrequent, informative GO terms more heavily than frequent, less informative GO terms, without arbitrary cutoffs, instead downweighting GO terms according to their frequency in the networks being aligned...
December 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29220305/spiking-neural-classifier-with-lumped-dendritic-nonlinearity-and-binary-synapses-a-current-mode-vlsi-implementation-and-analysis
#14
Aritra Bhaduri, Amitava Banerjee, Subhrajit Roy, Sougata Kar, Arindam Basu
We present a neuromorphic current mode implementation of a spiking neural classifier with lumped square law dendritic nonlinearity. It has been shown previously in software simulations that such a system with binary synapses can be trained with structural plasticity algorithms to achieve comparable classification accuracy with fewer synaptic resources than conventional algorithms. We show that even in real analog systems with manufacturing imperfections (CV of 23.5% and 14.4% for dendritic branch gains and leaks respectively), this network is able to produce comparable results with fewer synaptic resources...
December 8, 2017: Neural Computation
https://www.readbyqxmd.com/read/29202321/quantitative-analysis-of-breast-cancer-diagnosis-using-a-probabilistic-modelling-approach
#15
Shuo Liu, Jinshu Zeng, Huizhou Gong, Hongqin Yang, Jia Zhai, Yi Cao, Junxiu Liu, Yuling Luo, Yuhua Li, Liam Maguire, Xuemei Ding
BACKGROUND: Breast cancer is the most prevalent cancer in women in most countries of the world. Many computer-aided diagnostic methods have been proposed, but there are few studies on quantitative discovery of probabilistic dependencies among breast cancer data features and identification of the contribution of each feature to breast cancer diagnosis. METHODS: This study aims to fill this void by utilizing a Bayesian network (BN) modelling approach. A K2 learning algorithm and statistical computation methods are used to construct BN structure and assess the obtained BN model...
November 21, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29156456/impact-of-truncated-area-on-point-estimate-and-intra-subject-variability-in-bioequivalence-of-dutasteride-with-long-half-life
#16
Budi Prasaja, Yahdiana Harahap, Windy Lusthom, Lia Yumi, Anna Sofiana, Monica Sandra, Falah Safira, Uci Chilmi
Purpose To investigate the effect of using truncated area under the curve (AUC0-72) on bioequivalence of dutasteride with long half-life in point estimate and intra-subject variability. Methods Fifteen subjects were enrolled in this single-dose, open-label, randomized two-way crossover design following an overnight fasting with five-week washout period. Plasma samples were collected to 72 h and 144 h following drug administration and dutasteride were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods...
November 20, 2017: Drug Research
https://www.readbyqxmd.com/read/29137863/results-and-functional-outcomes-of-acute-ischemic-stroke-patients-who-underwent-mechanical-thrombectomy-admitted-to-intensive-care-unit
#17
L Viña Soria, L Martín Iglesias, L López Amor, I Astola Hidalgo, R Rodríguez García, L Forcelledo Espina, J A Gonzalo Guerra, S de Cima Iglesias, E Murias Quintana, P Vega Valdés, S Calleja Puerta, D Escudero Augusto
PURPOSE: To study the results and complications of endovascular treatment (EVT) in acute ischemic stroke patients admitted to Intensive Care Unit (ICU). To analyse the possible factors related to mortality and level of disability at ICU discharge and one year after stroke. DESIGN: Observational prospective study. SETTING: Mixed ICU. Third level hospital. PATIENTS: Sixty adult patients. Consecutive sample. INTERVENTIONS: None...
November 11, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29096638/empirical-study-of-seven-data-mining-algorithms-on-different-characteristics-of-datasets-for-biomedical-classification-applications
#18
Yiyan Zhang, Yi Xin, Qin Li, Jianshe Ma, Shuai Li, Xiaodan Lv, Weiqi Lv
BACKGROUND: Various kinds of data mining algorithms are continuously raised with the development of related disciplines. The applicable scopes and their performances of these algorithms are different. Hence, finding a suitable algorithm for a dataset is becoming an important emphasis for biomedical researchers to solve practical problems promptly. METHODS: In this paper, seven kinds of sophisticated active algorithms, namely, C4.5, support vector machine, AdaBoost, k-nearest neighbor, naïve Bayes, random forest, and logistic regression, were selected as the research objects...
November 2, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29074509/cognitive-complexity-of-clients-and-counsellors-during-motivation-based-treatment-for-smoking-cessation-an-observational-study-on-occasional-smokers-in-a-us-college-sample
#19
Lucian Gideon Conway, Kari Jo Harris, Delwyn Catley, Laura Janelle Gornick, Kathrene Renee Conway, Meredith A Repke, Shannon C Houck
OBJECTIVE: Motivational interviewing (MI) is a widely used and promising treatment approach for aiding in smoking cessation. The present observational study adds to other recent research on why and when MI works by investigating a new potential mechanism: integrative complexity. SETTING: The study took place in college fraternity and sorority chapters at one large midwestern university. PARTICIPANTS: Researchers transcribed MI counselling sessions from a previous randomised controlled trial focused on tobacco cessation among college students and subsequently scored clients' and counsellors' discussions across four counselling sessions for integrative complexity...
October 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/29070866/dominant-control-of-agriculture-and-irrigation-on-urban-heat-island-in-india
#20
Rahul Kumar, Vimal Mishra, Jonathan Buzan, Rohini Kumar, Drew Shindell, Matthew Huber
As is true in many regions, India experiences surface Urban Heat Island (UHI) effect that is well understood, but the causes of the more recently discovered Urban Cool Island (UCI) effect remain poorly constrained. This raises questions about our fundamental understanding of the drivers of rural-urban environmental gradients and hinders development of effective strategies for mitigation and adaptation to projected heat stress increases in rapidly urbanizing India. Here we show that more than 60% of Indian urban areas are observed to experience a day-time UCI...
October 25, 2017: Scientific Reports
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