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https://www.readbyqxmd.com/read/28928319/effect-of-a-brief-smoking-cessation-intervention-on-adult-tobacco-smokers-with-pulmonary-tuberculosis-a-cluster-randomized-controlled-trial-from-north-india
#1
Sonu Goel, Jeyashree Kathiresan, Preeti Singh, Rana J Singh
BACKGROUND: An association between smoking and poor tuberculosis (TB) treatment outcomes has been globally established. Various smoking cessation interventions (SCIs) have been proven worldwide to curb smoking behavior. There is a need for evidence to assess if SCI increases the chance of successful treatment outcome among TB patients. OBJECTIVES: To assess the effectiveness of a brief SCI; The Ask, Brief, Cessation support (ABC) package, on treatment outcomes and smoking cessation in smear-positive adult pulmonary TB patients...
September 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28924924/predictors-of-microbiologically-confirmed-intrathoracic-tuberculosis
#2
Rakhi Jain, Aparna Mukherjee, Mohit Singla, Yogita Verma, Hitender Gautam, Rakesh Lodha, Urvashi B Singh, Sushil K Kabra
OBJECTIVE: To identify risk factors for microbiologically confirmed intrathoracic tuberculosis in children. METHODS: Children, 6 mo to 15 y of age, attending the out-patient department of a tertiary care centre in India, with probable intrathoracic tuberculosis were enrolled. Microbiological confirmation of tuberculosis was defined as positivity on smear (Ziehl-Neelsen staining) and/or Xpert MTB/RIF and/or MGIT-960 culture. Association of various factors with microbiological confirmation were assessed by univariate and multivariate analysis...
September 19, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28913172/finding-tuberculosis-in-prisons-in-india-who-benefits
#3
EDITORIAL
Nevin Wilson
No abstract text is available yet for this article.
March 21, 2017: Public Health Action
https://www.readbyqxmd.com/read/28911360/evaluation-of-the-tb-lamp-assay-for-the-rapid-diagnosis-of-pulmonary-tuberculosis-in-northern-india
#4
R Yadav, N Sharma, R Khaneja, P Agarwal, A Kanga, D Behera, S Sethi
SETTING: A tertiary care hospital in North India. OBJECTIVE: To evaluate a commercial kit-based loop-mediated isothermal amplification (TB-LAMP) assay for the diagnosis of pulmonary tuberculosis (PTB). DESIGN: A total of 530 patients presenting with PTB symptoms were enrolled and one sputum sample was collected from each patient. The TB-LAMP assay (Loopamp™ MTBC Detection kit) was performed on the raw sputum sample. The remaining sample was used for smear microscopy and mycobacterial culture...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28911354/drug-resistance-patterns-among-extra-pulmonary-tuberculosis-cases-in-a-tertiary-care-centre-in-north-india
#5
S K Sharma, J Chaubey, B K Singh, R Sharma, A Mittal, A Sharma
BACKGROUND: xtra-pulmonary tuberculosis (EPTB) is a growing public health concern, and data on drug resistance are limited. MATERIAL AND METHODS: Specimens from 2468 clinically diagnosed EPTB patients received at the Intermediate Reference Laboratory (IRL) of a tertiary centre in India were subjected to Ziehl-Neelsen staining, Xpert® MTB/RIF testing, liquid culture and drug susceptibility testing (DST) using automated BACTEC MGIT™ 960™. Line-probe assay (LPA) was performed on all culture-positive isolates...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28910309/pattern-and-severity-of-multimorbidity-among-patients-attending-primary-care-settings-in-odisha-india
#6
Sanghamitra Pati, Subhashisa Swain, Job Metsemakers, J André Knottnerus, Marjan van den Akker
Multimorbidity is increasingly the primary concern of healthcare systems globally with substantial implications for patient outcomes and resource cost. A critical knowledge gap exists as to the magnitude of multimorbidity in primary care practice in low and middle income countries with available information limited to prevalence. In India, primary care forms the bulk of the health care delivery being provided through both public (community health center) and private general practice setting. We undertook a study to identify multimorbidity patterns and relate these patterns to severity among primary care attendees in Odisha state of India...
2017: PloS One
https://www.readbyqxmd.com/read/28892960/a-rare-case-of-primary-calcific-pleural-tuberculosis-a-case-report
#7
G Sahana, Vishak Acharya, Santosh Rai, Nishanth Baliga
Tuberculosis is a highly prevalent disease in India. It has a myriad of presentations. Usually pleural tuberculosis occur secondary to pulmonary tuberculosis which can manifest as pleural effusion leading to pleural calcification. Primary pleural calcification due to tuberculosis is an extremely rare manifestation of active tuberculosis. We present a case of a 21-year-old female presenting with fever, cough, weight loss and loss of appetite who was diagnosed to have pleural calcification due to primary tuberculosis...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892917/tubercular-thyroiditis-as-a-part-of-disseminated-tuberculosis-in-a-young-male-a-rare-clinical-presentation
#8
Vandana Baloda, Arun Choudhary, Pradeep Chugh, Rashmi Aggarwal
Thyroid tuberculosis is uncommon even in countries like India where prevalence of tuberculosis is high. Bactericidal actions of colloid, excess iodine stores and high vascularity of the gland have been implicated for the very rare occurrence of thyroid tuberculosis. We present a case of a 16-year-old male with thyroid involvement as a part of disseminated tuberculosis. The clinical presentation of thyroid tuberculosis is varied and may be missed if not kept in the differential diagnosis of goitre. This case also highlights the role of fine needle aspiration cytology in management of goitre...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892896/detection-of-cytomegalovirus-in-bronchoalveolar-lavage-fluid-from-hiv-positive-individuals-with-community-acquired-pneumonia
#9
Arati Mane, Pankaj Gujar, Shraddha Gaikwad, Tilak Dhamgaye, Arun Risbud
INTRODUCTION: Cytomegalovirus (CMV) pneumonia is one of the frequent viral pneumonia reported in persons with HIV infection. Knowledge of pulmonary CMV infection is important for deciding appropriate diagnostic strategies. However, there is scanty literature addressing the role of CMV aetiology among HIV positive individuals presenting with Community Acquired Pneumonia (CAP) using Bronchoalveolar Lavage (BAL) samples from India. AIM: To detect CMV in BAL fluid from HIV-positive individuals presenting with CAP...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28880875/scaling-up-the-xpert-mtb-rif-assay-for-the-detection-of-tuberculosis-and-rifampicin-resistance-in-india-an-economic-analysis
#10
Sunil Khaparde, Neeraj Raizada, Sreenivas Achuthan Nair, Claudia Denkinger, Kuldeep Singh Sachdeva, Chinnambedu Nainarappan Paramasivan, Virender Singh Salhotra, Anna Vassall, Anja Van't Hoog
BACKGROUND: India is considering the scale-up of the Xpert MTB/RIF assay for detection of tuberculosis (TB) and rifampicin resistance. We conducted an economic analysis to estimate the costs of different strategies of Xpert implementation in India. METHODS: Using a decision analytical model, we compared four diagnostic strategies for TB patients: (i) sputum smear microscopy (SSM) only; (ii) Xpert as a replacement for the rapid diagnostic test currently used for SSM-positive patients at risk of drug resistance (i...
2017: PloS One
https://www.readbyqxmd.com/read/28869693/diabetes-prevalence-and-its-impact-on-health-related-quality-of-life-in-tuberculosis-patients
#11
Ali Nasir Siddiqui, Khalid Umer Khayyam, Nahida Siddiqui, Rohit Sarin, Manju Sharma
OBJECTIVE: To determine the prevalence of diabetes mellitus (DM), assess its influence on health-related quality of life (HRQoL) among TB patients. METHODS: In this prospective study, eligible patients at three primary health care centers in urban slum region of South Delhi, India, underwent blood glucose screening at treatment initiation. HRQoL scores were determined by conducting face-to-face interviews using Dhingra and Rajpal (DR-12) scale at pretreatment, end of intensive phase and end of the treatment...
September 4, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28869227/a-study-on-beijing-genotype-in-the-clinical-isolates-of-pulmonary-drug-resistant-tuberculosis
#12
Ankit Kumar, Ajay Kumar Verma, Surya Kant, Ved Prakash, Anand Srivastava, Kanchan Srivastava, Amita Jain, Kishore K Srivastava
BACKGROUND: Mycobacterium tuberculosis (MTB) Beijing strains are spread worldwide and are responsible for major outbreaks of tuberculosis (TB), sometimes spreading multidrug resistance (MDR). AIM: The aim of this study was to explore clinical features associated with the infection with Beijing strains among MDR patients of pulmonary TB in Lucknow and surrounding areas. MATERIALS AND METHODS: It was a hospital-based epidemiological study. Our study population was selected from all the newly diagnosed patients attending outpatient department and admitted patients of Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28869226/inconsistency-in-the-reporting-of-antitubercular-drug-susceptibility-tests-in-an-endemic-region
#13
Avinandan Saha, Preyas J Vaidya, Vinod B Chavhan, Kamlesh V Pandey, Arvind H Kate, Prashant N Chhajed
BACKGROUND: Individualized treatment for multidrug-resistant tuberculosis (MDR TB) is associated with improved outcomes. Therapy needs to be tailored to drug susceptibility testing (DST) results. We present our observations on the inconsistency in DST reporting in an endemic region with a high prevalence of MDR TB. METHODS: We retrospectively analyzed 118 DST reports from 10 different laboratories. OBSERVATIONS: Of 118 patients, only 79 (67%) had DST reports with results to all first-line drugs, a fluoroquinolone (excluding ciprofloxacin), all aminoglycosides, and a polypeptide...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28869224/evaluation-of-tuberculosis-associated-chronic-obstructive-pulmonary-disease-at-a-tertiary-care-hospital-a-case-control-study
#14
Deepak Aggarwal, Anubhav Gupta, A K Janmeja, Manisha Bhardwaj
CONTEXT: Irreversible airway obstruction is important sequelae of pulmonary tuberculosis (TB) that might contribute to a significant proportion of chronic obstructive pulmonary disease (COPD). India has the highest TB burden in the world. However, there are limited data on the prevalence and presentation of TB-associated COPD from this region. AIMS: This study aims to evaluate the prevalence of TB-associated COPD among COPD patients presenting to a tertiary care hospital...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28869222/2025-too-short-time-to-eliminate-tuberculosis-from-india
#15
EDITORIAL
Rajendra Prasad, Nikhil Gupta, Amitabh Banka
No abstract text is available yet for this article.
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28862186/food-significantly-reduces-plasma-concentrations-of-first-line-anti-tuberculosis-drugs
#16
Agibothu Kupparam Hemanth Kumar, Vedachalam Chandrasekaran, Angadi Kiran Kumar, M Kawaskar, J Lavanya, Soumya Swaminathan, Geetha Ramachandran
BACKGROUND & OBJECTIVES: Concomitant feeding and anti-tuberculosis (TB) drug administration are likely to reduce nausea and enhance compliance to treatment. However, food could lower plasma drug concentrations. This study was undertaken to examine the effect of food on two-hour plasma concentrations of rifampicin (RMP), isoniazid (INH) and pyrazinamide (PZA), and pharmacokinetics of these drugs in adult TB patients. METHODS: Newly diagnosed adult TB patients were recruited from the Revised National Tuberculosis Control Programme (RNTCP) treatment centres in Chennai Corporation, Chennai, India...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28862176/index-tb-guidelines-guidelines-on-extrapulmonary-tuberculosis-for-india
#17
Surendra K Sharma, H Ryan, Sunil Khaparde, K S Sachdeva, Achintya D Singh, Alladi Mohan, Rohit Sarin, C N Paramasivan, Prahlad Kumar, Neeraj Nischal, Saurav Khatiwada, Paul Garner, Prathap Tharyan
Extrapulmonary tuberculosis (EPTB) is frequently a diagnostic and therapeutic challenge. It is a common opportunistic infection in people living with HIV/AIDS and other immunocompromised states such as diabetes mellitus and malnutrition. There is a paucity of data from clinical trials in EPTB and most of the information regarding diagnosis and management is extrapolated from pulmonary TB. Further, there are no formal national or international guidelines on EPTB. To address these concerns, Indian EPTB guidelines were developed under the auspices of Central TB Division and Directorate of Health Services, Ministry of Health and Family Welfare, Government of India...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28861733/patterns-of-uveitis-in-children-at-the-apex-institute-for-eye-care-in-india-analysis-and-review-of-literature
#18
Brijesh Takkar, Pradeep Venkatesh, Nripen Gaur, Sat Pal Garg, Rajpal Vohra, Supriyo Ghose
AIM: To study patterns of uveitis in Indian children and compare with data sets published earlier in the literature. METHODS: Consecutive patients below 16 years of age presenting to the uvea clinic of a tertiary eye care center were included prospectively through the period of July 2009-August 2013. Children with retinal vasculitis, exogenous endophthalmitis and masquerade syndromes were excluded from analysis. Uveitis was classified as per the nomenclature system adopted by the International Uveitis Study Group...
August 31, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28861650/optimal-timing-of-drug-sensitivity-testing-for-patients-on-first-line-tuberculosis-treatment
#19
Sze-Chuan Suen, Margaret L Brandeau, Jeremy D Goldhaber-Fiebert
Effective treatment for tuberculosis (TB) patients on first-line treatment involves triaging those with drug-resistant (DR) TB to appropriate treatment alternatives. Patients likely to have DR TB are identified using results from repeated inexpensive sputum-smear (SS) tests and expensive but definitive drug sensitivity tests (DST). Early DST may lead to high costs and unnecessary testing; late DST may lead to poor health outcomes and disease transmission. We use a partially observable Markov decision process (POMDP) framework to determine optimal DST timing...
August 31, 2017: Health Care Management Science
https://www.readbyqxmd.com/read/28852286/sputum-conversion-and-treatment-success-among-tuberculosis-patients-with-diabetes-treated-under-the-tuberculosis-control-programme-in-an-urban-setting-in-south-india
#20
Velayutham Banurekha, Tarun Bhatnagar, Swaminathan Savithri, Natarajan Dinesh Kumar, Boopathi Kangusamy, Sanjay Mehendale
BACKGROUND: Studies from India on sputum conversion and tuberculosis (TB) treatment outcomes among TB patients with diabetes are limited. OBJECTIVE: The objective of this study is to estimate the proportion of sputum smear conversion and successful treatment outcomes among diabetic-TB patients treated under Revised National TB Control Programme (RNTCP). METHODOLOGY: Information on TB disease, diabetes, sputum conversion, and treatment outcomes were collected from treatment cards of adult TB patients (age >18 years) treated in the District TB Centre TB Unit, Tiruchirapalli, Tamil Nadu from July 1, 2014, to October 31, 2015...
July 2017: Indian Journal of Community Medicine
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