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https://www.readbyqxmd.com/read/27893931/infliximab-induced-tuberculosis-in-patients-with-uc-experience-from-a-country-with-high-prevalence-of-tuberculosis-india
#1
Amarender S Puri, Devendra Desai, Ajit Sood, Sanjeev Sachdeva
BACKGROUND & AIM: Tuberculosis (TB) is a well-recognized iatrogenic adverse event following administration of biologic therapy given for a variety of clinical indications. There is paucity of data on the development of TB following use of biologics from countries with a high prevalence of TB. The aim of this study was to determine the risk of development of TB following biological therapy in a country, which is highly endemic for TB. METHODS: Retrospective analysis of data from 3 referral IBD centers to evaluate the risk of development of TB following biological therapy for patients with UC...
November 28, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27891362/health-seeking-behaviour-among-tuberculosis-patients-in-india-a-systematic-review
#2
REVIEW
Janmejaya Samal
INTRODUCTION: The Revised National Tuberculosis Control Programme's (RNTCP) passive case finding approach strongly influence the health seeking behaviour of patients and the timing of health seeking as well. AIM: A systematic review was carried out to understand the health seeking behaviour, related delays and the knowledge and attitude regarding Tuberculosis (TB) and the health services linked with it. MATERIALS AND METHODS: A manual search strategy was adopted using PUBMED and Google Scholar search engines to obtain research papers in the said subject...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890948/study-of-infections-among-human-immunodeficiency-virus-acquired-immunodeficiency-syndrome-patients-in-shadan-hospital-telangana-india
#3
Sukumar Gajjala Reddy, Syed Yousuf Ali, Azheel Khalidi
BACKGROUND: Human immunodeficiency virus (HIV) pandemicity is a major concern today as it causes greater loss of productivity than any other disease. HIV infection leads to profound immune deficiency and patients become highly susceptible to opportunistic infections (OIs). HIV epidemic in India is heterogeneous in nature, both in terms of routes of transmission as well as geographical spread. AIMS: (1) Determine prevalence of OIs among HIV-seropositive patients and their relation to CD4 count and to focus on the routes of transmission...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27875116/toward-a-comprehensive-cure-digital-information-and-communication-technology-is-helping-to-meet-health-care-challenges-in-india
#4
Debdoot Sheet
How would you provide effective and affordable health care in a country of more than 1.25 billion where there are only 0.7 physicians for every 1,000 people [1]? The Revised National Tuberculosis Control Program (RNTCP) and the Karnataka Internet-Assisted Diagnosis of Retinopathy of Prematurity (KIDROP) service are two notable efforts designed to deliver care across India, in both urban and rural areas and from the country?s flat plains to its rugged mountainous and desert regions.
November 2016: IEEE Pulse
https://www.readbyqxmd.com/read/27865244/tubercular-osteomyelitis-of-calcaneum-bone-a-rare-occurrence
#5
Rajendra Takhar, Motilal Bunkar, Savita Arya, Nitin Mirdha
In spite of the endemic nature of tuberculosis in India, skeletal tuberculosis is relatively infrequent. Involvement of foot bones is uncommon and isolated calcaneum is even rarer. Osteoarticular tuberculosis is a diagnostic enigma, as the characteristic signs and symptoms of this disease may be absent, or mimic other disorders, leading to emergence of complications and therapeutic delay, particularly when the disease affects unusual sites. Here, we are reporting the case of 20-year-old male, who presented with a rare localization of tubercular osteomyelitis involving the calcaneum without adjacent joint involvement to draw attention to this exceptional location in adults, managed with anti-tubercular treatment and gained excellent recovery...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865243/lessons-learnt-from-active-tuberculosis-case-finding-in-an-urban-slum-setting-of-agra-city-india
#6
Banuru Muralidhara Prasad, Srinath Satyanarayana, Sarabjit Singh Chadha
Active case finding (ACF) is recognized as one of the key strategies to reach the missing 3 million cases in high tuberculosis (TB) burden countries. In India, we conducted ACF as a pilot project to assess its operational feasibility in four slums of Agra city in 2012 and covered 3940 households (in 14 wards) with a population of 21,870. Trained community volunteers visited households with an intention to provide information on TB and refer those with cough ≥2 weeks for sputum smear examination. Volunteers identified 8 persons with cough of ≥2 weeks by asking the first or the main respondent of the household...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865242/a-study-on-knowledge-and-awareness-about-tuberculosis-in-senior-school-children-in-bangalore-india
#7
K Vanaja, Reshma Banu, Lokeshwar Reddy, P Chethan Kumar, Chaitra Srinivas, T Rajani, Navyashree, H S Shekar
BACKGROUND: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis), commonly affecting the lungs. All health care professionals including the pharmacists provide a valuable public health role in promoting community awareness of TB particularly in reducing stigma attached to TB. Thus, creating awareness at a community level could play a vital role in control and prevention of TB. OBJECTIVES: To determine whether educational intervention would affect the level of TB awareness among students of selected schools and pre-university colleges (PUCs) in Bangalore urban and Bangalore rural regions...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865238/tuberculosis-prevalence-and-socio-economic-differentials-in-the-slums-of-four-metropolitan-cities-of-india
#8
Palaniappan Marimuthu
AIM: To understand tuberculosis (TB) prevalence among the slum dwellers of metropolitan cities of India and the factors associated with TB prevalence. METHODS: National Family Health Survey-III data for four metropolitan cities namely, Delhi, Mumbai, Kolkata and Chennai was used for this study. RESULTS: Prevalence of TB is significantly (P=0.001) higher in the slums than non-slums of Mumbai, Chennai and Kolkata cities. As the living standard increases, TB prevalence decreases...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865237/smoked-and-smokeless-tobacco-use-among-pulmonary-tuberculosis-patients-under-rntcp-in-urban-puducherry-india
#9
Veerakumar Arumugam Mariappan, Swaroop Kumar Sahu, Sonali Sarkar, Shivanand Kattimani, Govindarajan Soundappan
BACKGROUND: Smoking is associated with unfavourable treatment outcomes like failures and defaults among the TB patients. OBJECTIVES: To study the prevalence and pattern of tobacco use among the pulmonary tuberculosis (PTB) patients in urban Pondicherry and study the association of various socio-demographic variables with current smoked and smokeless tobacco users. METHODS: A cross-sectional study was conducted among 235 PTB patients from 6 randomly selected urban PHCs of Pondicherry from Jan 2013 to March 2014...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865235/role-of-real-time-pcr-for-detection-of-tuberculosis-and-drug-resistance-directly-from-clinical-samples
#10
Parashuram Rao, Kiran Chawla, Vishnu Prasad Shenoy, Chiranjay Mukhopadhyay
BACKGROUND: Only a few studies done earlier in India reveal the utility of real-time PCR in detecting drug resistance in cases of pulmonary tuberculosis. OBJECTIVES: The study was carried out to standardise real-time PCR (Quantitative real-time PCR, qPCR) targeting 16s RNA for the rapid detection of tuberculosis and its drug resistance from suspected TB patients. MATERIALS AND METHODS: Sputum samples from 100 clinically suspected tuberculosis patients, after processing were subjected to microscopy, MGIT culture and qPCR...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865234/rapid-detection-of-extensively-drug-resistant-xdr-tb-strains-from-multidrug-resistant-tuberculosis-mdr-tb-cases-isolated-from-smear-negative-pulmonary-samples-in-an-intermediate-reference-laboratory-in-india
#11
Himanshu Vashistha, M Hanif, Sanjeev Saini, Ashwani Khanna, Srashty Sharma, Zeeshan Sidiq, Vasim Ahmed, Manoj Dubey, K K Chopra, Divya Shrivastava
BACKGROUND: Direct sputum smear microscopy is commonly used for diagnosing tuberculosis (TB). The objectives of the study were first, to determine the recovery of Mycobacterium tuberculosis in smear-negative sputum samples through liquid culture (using MGIT 960) and solid culture (using LJ slant) and second, to screen multidrug-resistant isolates through line probe assay and further third, to identify XDR isolates through MGIT second-line DST from these positive MDR cultures in Delhi region...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27847023/protein-tyrosine-phosphatase-nonreceptor-type-22-ptpn22-gene-polymorphism-in-pulmonary-tuberculosis-in-the-indian-population
#12
Vydyanath R Narasimha, Kalpana Panati, M Gangadhara Reddy, Venkata Ramireddy Narala
A variant of the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene is known to be associated with susceptibility to autoimmune diseases and bacterial infections as it acts as an important regulator of T-cell activation. The objective of this study was to evaluate whether PTPN22-C1858T polymorphism is associated with the resistance to pulmonary tuberculosis (PTB). Single-nucleotide polymorphism of PTPN22-C1858T (rs2476601) was genotyped in 124 patients with PTB and 130 healthy controls from India using restriction fragment length polymorphism and direct sequencing of the amplified DNA...
September 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27847012/prevalence-and-species-spectrum-of-both-pulmonary-and-extrapulmonary-nontuberculous-mycobacteria-isolates-at-a-tertiary-care-center
#13
Jyoti Umrao, Dharamveer Singh, Amreen Zia, Swati Saxena, Surendra Sarsaiya, Shushma Singh, Jahanarah Khatoon, Tapan N Dhole
OBJECTIVE/BACKGROUND: Nontuberculous mycobacteria (NTM) infection associated with pulmonary and extrapulmonary disease has been increasing globally. Despite an increase in incidence rate of NTM infection, its prevalence, species diversity, and circulation pattern in India is largely unknown. This study sought to investigate the overall burden and diversity of NTM among both pulmonary and extrapulmonary clinical isolates from a Northern Indian population. METHODS: The study was conducted in the Department of Microbiology, from January 2013 to December 2015...
September 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27847007/adequacy-of-examining-one-sputum-specimen-in-tuberculosis-drug-resistance-surveys
#14
Subramanyam Balaji, Vanaja Kumar, Prabu Seenivasan, R Radhakrishnan, Gomathi Sekar, Thiruvengadam Kannan, Vedhachalam Chandrasekaran, Soumya Swaminathan, Nagamiah Selvakumar
OBJECTIVE/BACKGROUND: Collection of one spot and one morning sputum specimen is recommended for tuberculosis (TB) drug resistance surveys. This was a retrospective analysis of Mycobacterium tuberculosis cultures isolated from two spot sputum specimens collected from smear positive TB patients in a TB drug resistance survey. It was conducted to understand the value of a second specimen. METHODS: A TB drug resistance survey was conducted in the state of Tamil Nadu, India, to estimate the prevalence of drug resistance among new sputum smear-positive (NSP) and previously treated (PT) patients diagnosed in Revised National Tuberculosis Control Program microscopy centers...
September 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27842543/design-of-the-indian-nca-study-indian-national-collaboration-on-aids-a-cluster-randomized-trial-to-evaluate-the-effectiveness-of-integrated-care-centers-to-improve-hiv-outcomes-among-men-who-have-sex-with-men-and-persons-who-inject-drugs-in-india
#15
Sunil S Solomon, Gregory M Lucas, David D Celentano, Allison M McFall, Elizabeth Ogburn, Lawrence H Moulton, Aylur K Srikrishnan, M Suresh Kumar, Santhanam Anand, Suniti Solomon, Shruti H Mehta
BACKGROUND: Globally, men who have sex with men and people who inject drugs remain disproportionately affected by HIV, but they have not been the focus of prevention and treatment interventions in many resource-limited settings. METHODS/DESIGN: This cluster-randomized trial (conducted from June 2012 to June 2017), evaluates whether single-venue, integrated delivery of core HIV services to vulnerable high-risk populations improves service utilization and consequently, HIV testing and other outcomes along the HIV care continuum...
November 14, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27835999/serial-survey-shows-community-intervention-may-contribute-to-increase-in-knowledge-of-tuberculosis-in-30-districts-of-india
#16
Badri Thapa, Banuru Muralidhara Prasad, Sarabjit S Chadha, Jamie Tonsing
BACKGROUND: Correct knowledge about Tuberculosis (TB) is essential for appropriate healthcare seeking behaviour and to accessing diagnosis and treatment services timely. There are several factors influencing knowledge about TB. The present study was conducted to assess the change in community knowledge of Tuberculosis (TB) and its association with respondent's socio-demographic characteristics in two serial knowledge-attitude-practice surveys. METHODS: Community level interventions including community meetings with youth groups, village health committees and self-help groups and through mass media activities were undertaken to create awareness and knowledge about TB and service availability...
November 11, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27834321/undernutrition-tuberculosis-in-india-situation-analysis-the-way-forward
#17
REVIEW
C Padmapriyadarsini, M Shobana, M Lakshmi, T Beena, Soumya Swaminathan
Undernutrition and tuberculosis (TB) are linked and have a bidirectional relationship. Undernutrition increases the risk of TB which in turn, can lead to malnutrition. Undernutrition not only is a risk factor for progression of latent TB infection to active disease, but also increases the risk of drug toxicity, relapse and death once TB develops. The dietary intake of TB patients in the country is inadequate. Nutritional supplementation in patients with TB is associated with faster sputum conversion, higher cure and treatment completion rates, significant gain in body weight and body composition as well as better performance status...
July 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27833911/concurrent-resolution-of-chronic-diarrhea-likely-due-to-crohn-s-disease-and-infection-with-mycobacterium-avium-paratuberculosis
#18
Shoor V Singh, J Todd Kuenstner, William C Davis, Prabhat Agarwal, Naveen Kumar, Devendra Singh, Saurabh Gupta, Kundan K Chaubey, Ashok Kumar, Jyoti Misri, Sujatha Jayaraman, Jagdip S Sohal, Kuldeep Dhama
Examination of samples of stool from a 61-year-old male patient, presenting with the clinical symptoms of Crohn's disease (CD), revealed massive shedding of acid fast bacilli with the morphology of Mycobacterium avium paratuberculosis (MAP), the causative agent of Johne's disease in cattle. MAP was cultured from the stool. Biotyping of the bacterium isolated from cultures of stool demonstrated, it was the Indian Bison biotype of MAP, the dominant biotype infecting livestock and humans in India. Based on this finding and because the patient was unresponsive to standard therapy used in India to treat patients with gastrointestinal inflammatory disorders, the patient was placed on a regimen of multi-antibiotic therapy, currently used to treat tuberculosis and CD...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27833578/quality-of-life-psychological-interventions-and-treatment-outcome-in-tuberculosis-patients-the-indian-scenario
#19
REVIEW
Vidyullatha Peddireddy
Objective: Psychological distress is being recognized in individuals affected with many diseases since it affects quality of life (QOF) and has gained importance in the clinical settings. Psychological interventions and their effect on the treatment outcome have yielded encouraging results in many diseased conditions. Tuberculosis (TB) ranks as a deadly disease resulting in millions of deaths worldwide. However, the effect of TB on the psychological status of patients and interventions to improve treatment outcome is neglected, especially in underdeveloped and developing countries...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27822380/chronic-melioidosis-presenting-with-multiple-abscesses
#20
Anshul Goel, Rahul Bansal, Shweta Sharma, Suman Singhal, Ashok Kumar
Melioidosis is common in Australia and Southeast Asia and is increasingly recognized in India. It presents in various forms which are difficult to identify and often mimics suppurative infections, tuberculosis, fungal infections, malignancy and systemic rheumatic diseases. Presentation may vary from local disease to disseminated abscesses, pneumonia and sepsis. Disease is common and severe in diabetics. We describe a case of diabetic man presenting with fever, septic shock, peri-articular nodules, lung opacities and multiple abscesses in muscles for the past 3 months remaining undiagnosed...
January 2016: Oxford Medical Case Reports
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