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Elisabetta de Alteriis, Fabrizio Cartenì, Palma Parascandola, Jacinta Serpa, Stefano Mazzoleni
The mechanisms beyond the Warburg effect in proliferative mammalian cells, as well as for the similar Crabtree effect in the yeast Saccharomyces cerevisiae, are still a matter of debate: why do cells shift from the energy-efficient respiration to the energy-inefficient fermentation at high sugar concentration? This review reports on the strong similarities of these phenomena in both cell types, discusses the current ideas, and provides a novel interpretation of their common functional mechanism in a dynamic perspective...
March 6, 2018: Cell Cycle
Xingde Liu, Wenxiu Yang, Zhizhong Guan, Wenfeng Yu, Bin Fan, Ningzhi Xu, D Joshua Liao
There have been enough cell death modes delineated in the biomedical literature to befuddle all cell death researchers. Mulling over cell death from the viewpoints of the host tissue or organ and of the host animal, we construe that there should be only two physiological cell death modes, i.e. apoptosis and senescent death (SD), as well as two pathological modes, i.e. necrosis and stress-induced cell death (SICD). Other death modes described in the literature are ad-hoc variants or coalescences of some of these four basic ones in different physiological or pathological situations...
2018: Cell & Bioscience
Asim S Ahmed, Parin J Patel, Shiv Bagga, Jasen L Gilge, Thomas Schleeter, Baqir A Lakhani, Ashwin K Ravichandran, Steve Donnelley, Venu Allavatam, Eric N Prystowsky, Benzy J Padanilam
A 25-year-old man with severe non-ischemic dilated cardiomyopathy underwent subcutaneous implantable cardioverter defibrillator (S-ICD) implant and subsequently underwent Heartware ventricular assist device (HVAD) placement. Post-operative interrogation revealed both primary and secondary S-ICD vectors inappropriately regarded sinus rhythm as "noise," and the alternate vector significantly under-sensed sinus rhythm. The S-ICD was re-interrogated using high resolution capture to visually confirm EMI with a dominant frequency in both the primary and secondary vectors of 46...
January 24, 2018: Journal of Cardiovascular Electrophysiology
Matthew Campbell, Jeremy P Moore, Narayanswami Sreeram, Johannes C von Alvensleben, Anjan Shah, Anjan Batra, Ian Law, Shubhayan Sanatani, Vincent Thomas, Farnoosh Nik-Ahd, Stephen Williams, Nina Nosavan, Jennifer Maldonado, Amelia Hart, Thuan Nguyen, Seshadri Balaji
BACKGROUND: Subcutaneous Implantable Cardioverter Defibrillator (SICD) shows promise for select patients at risk for sudden death. However, patients need to pass an ECG screening (ECG-S) test before they can receive an SICD. Predictors of ECG-S failure in children are unclear. OBJECTIVE: To identify the incidence and predictive factors for failure of ECG-S in children. METHODS: Children ≤18 years with a pre-existing ICD underwent SICD ECG-S...
January 5, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Mariusz S Wiglusz, Jerzy Landowski, Wiesław J Cubała
OBJECTIVE: Anxiety disorders (ADs) are common in patients with epilepsy (PWE). The aim of this study was to estimate the prevalence of specific ADs in outpatients with epilepsy. METHODS: A group of 118 consecutive outpatients with epilepsy were screened, and 96 patients meeting inclusion criteria were examined by a trained psychiatrist using Structured Clinical Interview (SICD-I) for Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (Text Revision) (DSM-IV-TR)...
February 2018: Epilepsy & Behavior: E&B
Mariusz S Wiglusz, Jerzy Landowski, Lidia Michalak, Wiesław J Cubała
BACKGROUND: Despite the fact that depressive disorders are the most common comorbidities among patients with epilepsy (PWE), such disorders often go unrecognized and untreated. In addition, the availability of validated screening instruments to detect depression in PWE is limited. The aim of the present study was thus to validate the Polish version of the Beck Depression Inventory (BDI) in adult PWE. METHODS: A group of 118 outpatient PWE were invited to participate in the study...
December 2017: Epilepsy & Behavior: E&B
Zheng Xie, Zhengmao Yin, Yongzhong Wu, Chunyan Liu, Xiaopeng Hao, Qingqing Du, Xiangang Xu
A search for new phosphor materials that exhibit high light-emission, spectral purity, long-time stability and processability capture particular attention to modern solid-state lighting. Here, polymerizable silane pre-functionalized carbon dot (SiCD) fluids were dripped and co-polymerized or completely bulk polymerized to build color conversion and encapsulation coatings of commercially available GaN blue LEDs. Most parameters of SiCD-based white LEDs were similar to or even better than those of phosphor-based white LEDs, particularly the insensitivity to excitation wavelength and working current...
September 22, 2017: Scientific Reports
Pau Alonso, Joaquín Osca, Joaquín Rueda, Oscar Cano, Pedro Pimenta, Ana Andres, María José Sancho, Luis Martinez
BACKGROUND: Information regarding suitability for subcutaneous defibrillator (sICD) implantation in tetralogy of Fallot (ToF) and systemic right ventricle is scarce and needs to be further explored. The main objective of our study was to determine the proportion of patients with ToF and systemic right ventricle eligible for sICD with both, standard and right-sided screening methods. Secondary objectives were: (i) to study sICD eligibility specifically in patients at high risk of sudden cardiac death, (ii) to identify independent predictors for sICD eligibility, and (iii) to compare the proportion of eligible patients in a nonselected ICD population...
May 15, 2017: Annals of Noninvasive Electrocardiology
Ci Wang, Jie Sun, Huiyang Gou, Shanpeng Wang, Jian Zhang, Xutang Tao
In view of their high nonlinear optical coefficients and good phase-matching properties, CdSiP2 (CSP) crystals are considered as one of the most promising materials in the field of nonlinear optical applications. However, the slight absorption losses around 1.34 μm and 1.78 μm under e-polarized light have been affecting its performance. In this study, first-principles calculations were performed to identify the effects of various charge defects on the absorption properties. Different intrinsic defects in the CSP crystal were calculated using the HSE method and compared according to the specific chemical environments in the experiments...
March 27, 2017: Physical Chemistry Chemical Physics: PCCP
Zhengxian Lv, Jinmao You, Shuaimin Lu, Weidi Sun, Zhongyin Ji, Zhiwei Sun, Cuihua Song, Guang Chen, Guoliang Li, Na Hu, Wu Zhou, Yourui Suo
As the key aroma compounds, varietal thiols are the crucial odorants responsible for the flavor of wines. Quantitative analysis of thiols can provide crucial information for the aroma profiles of different wine styles. In this study, a rapid and sensitive method for the simultaneous determination of six thiols in wine using d0/d4-acridone-10-ethyl-N-maleimide (d0/d4-AENM) as stable isotope-coded derivatization reagent (SICD) by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) has been developed...
March 31, 2017: Journal of Chromatography. A
Pau Alonso, Joaquín Osca, Oscar Cano, Pedro Pimenta, Ana Andrés, Jaime Yagüe, José Millet, Joaquín Rueda, María José Sancho-Tello
BACKGROUND: Information regarding suitability for subcutaneous implantable cardioverter-defibrillator (S-ICD) implant in tetralogy of Fallot (ToF) population is scarce and needs to be further explored. THE AIMS OF OUR STUDY WERE: (1) to determine the proportion of patients with ToF eligible for S-ICD, (2) to identify the optimal sensing vector in ToF patients, (3) to test specifically the eligibility for S-ICD with right-sided screening, and (4) to compare with the proportion of eligible patients in a nonselected ICD population...
February 2017: Pacing and Clinical Electrophysiology: PACE
Jason Huang, Kristen K Patton, Jordan M Prutkin
BACKGROUND: The subcutaneous implantable cardioverter defibrillator (S-ICD) is a novel implanted defibrillator for the prevention of sudden cardiac death that avoids intravascular access. Use of this device is limited by its inability to provide backup pacing. Combined use of the S-ICD with a permanent pacemaker may be the optimal choice in certain situations though experience with the use of both devices together remains limited. METHODS: We reviewed our single-center experience with the S-ICD from March 2011 to November 2015...
November 2016: Pacing and Clinical Electrophysiology: PACE
Li-Tzong Chen, Chiung-Tong Chen, Weir-Torn Jiaang, Tsai-Yun Chen, Joseph H Butterfield, Neng-Yao Shih, John Tsu-An Hsu, Hui-You Lin, Sheng-Fung Lin, Hui-Jen Tsai
Acute myelogenous leukemia (AML) carrying t(8;21)(q22;q22) or inv(16)/t(16;16)(p13;q22) is classified as core binding factor (CBF)-AML and accounts for approximately 15% of AML. c-KIT mutation can be detected in 17%∼46% of CBF-AML and is associated with poor prognosis. c-KIT mutation is a crucial hit and cooperates with AML1-ETO resulting from t(8;21)(q22;q22) to cause overt AML. Tyrosine kinase inhibitors (TKI) targeting c-KIT, such as imatinib, has been used successfully to treat c-KIT driven gastrointestinal stromal tumors...
October 2016: Molecular Cancer Therapeutics
D G Wilson, G Leventigiannis, C Barr, J M Morgan
BACKGROUND: T wave oversensing (TWOS) is the commonest cause of inappropriate shocks in subcutaneous implantable cardioverter defibrillators (S-ICDs). We hypothesise that predictors of TWOS can be derived from surface ECG parameters. METHODS: In a cohort of SICD recipients in two UK centres, all patients who had TWOS (study group) were compared to all those who had not (control group). The pre-implant screen was scanned and the R wave, T wave amplitudes, QRS interval, time to peak T wave, QT interval and R:T ratio was measured using digital callipers...
October 1, 2016: International Journal of Cardiology
N Y Chan, H C Yuen, N S Mok
BACKGROUND: Pre-operative electrocardiographic (ECG) screening before subcutaneous implantable cardioverter-defibrillator (SICD) implantation is essential to prevent T-wave oversensing and inappropriate shocks. The failure rate of ECG screening was reported to be up to 8% when only two body positions were tested. METHOD: Three subcutaneous ECG vectors represented by lead I, II and III were obtained in standing, supine, sitting and squatting positions. A patient qualified if the ECG in any same lead passed in all four positions...
December 2015: Heart, Lung & Circulation
Rajiv K Dhamija, Henry Tan, Edward Philbin, Roy O Mathew, Mandeep S Sidhu, Jeffrey Wang, Basil Saour, Syed S Haqqie, Gerald Beathard, Alexander S Yevzlin, Loay Salman, William E Boden, Gary Siskin, Arif Asif
Central venous stenosis is a common complication of the transvenous leads associated with an implantable cardioverter defibrillator (ICD). Although epicardial leads have been reported to bypass this complication, their placement is much more invasive than the subcutaneous ICDs (SICDs) and requires the services of a cardiothoracic surgeon. Recent data have demonstrated successful defibrillation using an SICD. In this report, we present 4 long-term hemodialysis patients treated successfully with an SICD. 3 patients received the device for primary prevention of sudden cardiac death (cardiomyopathy with low ejection fraction)...
July 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Mehmood Zeb, Paul Roberts, Arthur Yue, John Morgan
INTRODUCTION: Ambulatory cardiac monitoring devices and the novel subcutaneous ICD (SICD) sensing algorithms are based on the surface electrocardiograms (ECGs) parameters for detection and discrimination of arrhythmias. However the impact of posture, cardiac morphologies (normal and congenital heart diseases), and electrode placement on these parameters are not known. AIM: To determine the impact of posture (standing, sitting, supine, left lateral, right lateral) and bipolar electrode location (LI, LII, LIII), cardiac morphologies (normal, TOF, TGA, SVP) and gender on R-wave amplitude, T-wave amplitude, R/T ratio, QRS, QTc, Tpeak-end duration...
June 2014: Heart: Official Journal of the British Cardiac Society
Andrew Grace
PURPOSE OF REVIEW: To consider the case of need that underpinned the development of the subcutaneous implantable cardioverter-defibrillator (SICD), the preclinical and clinical data obtained so far, its current role and likely future. RECENT FINDINGS: The data from prospective clinical evaluation of the device demonstrated safety and efficacy leading to Food and Drug Administration approval. This superseded earlier reports from Europe that raised some clinical concerns, previously anticipated through the introduction of new technology...
January 2014: Current Opinion in Cardiology
F Reinke, A Löher, J Köbe, L Eckardt
Prevention of sudden cardiac death is one of the most important tasks of cardiology. Transvenous ICD-systems have impressively proven their effectiveness in numerous randomized trials. Transvenous systems have their limitations due to frequent long-term lead complications. Having been available for a few years, the entirely subcutaneous ICD-system (S-ICD®, Boston Scientific, USA, former Cameron Health, USA) seems to be a promising alternative despite the lack of prospective data. The implantation of the SICD® can be performed easily; lead complications are rare because of the totally subcutaneous implantation...
September 2013: Herzschrittmachertherapie & Elektrophysiologie
Riccardo Cappato, Serenella Castelvecchio, Paul Erlinger, Rick Sanghera, Donald Scheck, Alan Ostroff, William Rissmann, Charles Gropper, Gust H Bardy
INTRODUCTION: This study reports the experimental process leading to development of an automatic totally subcutaneous implantable cardioverter defibrillator (SICD) system engineered for human use. METHODS AND RESULTS: Two studies were conducted to test defibrillation and detection feasibility of an SICD system located in the left chest. In the first study, 2 pockets were created in 15 canines for placement of an anterior electrode adjacent to the left edge of the sternum and a lateral electrode at the site along the axillary line between the 4th and 6th intercostal space...
January 2013: Journal of Cardiovascular Electrophysiology
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