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https://www.readbyqxmd.com/read/29684848/protective-effects-of-ifn-%C3%AE-on-the-kidney-of-type-2-diabetic-kkay-mice
#1
Juan Du, Wenpeng Dong, Huifeng Li, Bo Li, Xiaodan Liu, Qinghui Kong, Wei Sun, Tingli Sun, Peilong Ma, Yan Cui, Ping Kang
BACKGROUND: Development of novel therapeutic strategies that specifically target diabetic kidney disease (DKD) is urgently needed. METHODS: Male KKAy mice were divided randomly into three equal groups - KK, KI, and KF; Male C57BL/6 mice were the control group. All KKAy mice were fed a high-fat diet. From the 16th week, the KI group was given IFN-γ, and the KF group was assigned to be treated with fludarabine. C57BL/6 mice were always fed a normal mouse diet. Every 4 weeks, body weight, random blood sugar, urine albumin and urea of all mice were measured...
December 21, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29684616/serum-fibrinogen-predicts-diabetic-esrd-in-patients-with-type-2-diabetes-mellitus
#2
Junlin Zhang, Yiting Wang, Rui Zhang, Hanyu Li, Qianqian Han, Yucheng Wu, Shanshan Wang, Ruikun Guo, Tingli Wang, Li Li, Fang Liu
AIMS: Although increased serum fibrinogen level was often observed in patients with diabetic nephropathy (DN), its association with DN severity and progression remains unclear. The aim of this study was to investigate the relationship between the serum fibrinogen levels and clinicopathological features and renal prognosis in Chinese patients with type 2 diabetes mellitus (T2DM) and DN. METHODS: A total of 174 patients with T2DM and biopsy-proven DN were enrolled...
April 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29684554/short-term-oral-gavage-administration-of-adenine-induces-a-model-of-fibrotic-kidney-disease-in-rats
#3
Chang Z Zhu, Kelly J Doyle, Arthur L Nikkel, Lauren Olsen, Marian T Namovic, Katherine Salte, Deborah Widomski, Zhi Su, Diana L Donnelly-Roberts, Murali M Gopalakrishnan, Steve McGaraughty
INTRODUCTION: The adenine model of kidney disease typically involves dietary delivery of adenine over several weeks. This model can be variable in its disease progression and can result in significant mortality. In the current study, the amount of adenine delivered to rats was controlled by utilizing oral gavage administration over a short period in an attempt to induce robust renal pathology while addressing variability and viability of the animals. METHODS: Adenine (150 or 200 mg/kg) was administered via oral gavage for 10 consecutive days, and assessed over a total of 20 days...
April 20, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29684213/low-thyroid-function-is-not-associated-with-an-accelerated-deterioration-in-renal-function
#4
Christiaan L Meuwese, Merel van Diepen, Anne R Cappola, Mark J Sarnak, Michael G Shlipak, Douglas C Bauer, Linda P Fried, Massimo Iacoviello, Bert Vaes, Jean Degryse, Kay-Tee Khaw, Robert N Luben, Bjørn O Åsvold, Trine Bjøro, Lars J Vatten, Anton J M de Craen, Stella Trompet, Giorgio Iervasi, Sabrina Molinaro, Graziano Ceresini, Luigi Ferrucci, Robin P F Dullaart, Stephan J L Bakker, J Wouter Jukema, Patricia M Kearney, David J Stott, Robin P Peeters, Oscar H Franco, Henry Völzke, John P Walsh, Alexandra Bremner, José A Sgarbi, Rui M B Maciel, Misa Imaizumi, Waka Ohishi, Friedo W Dekker, Nicolas Rodondi, Jacobijn Gussekloo, Wendy P J den Elzen
Background: Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups. Methods: Individual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29684175/aminoglycoside-exposure-and-renal-function-before-lung-transplantation-in-adult-cystic-fibrosis-patients
#5
Etienne Novel-Catin, Solenne Pelletier, Quitterie Reynaud, Raphaele Nove-Josserand, Stephane Durupt, Laurence Dubourg, Isabelle Durieu, Denis Fouque
Background: Patients with cystic fibrosis (CF) are at risk of kidney injury even before undergoing lung transplantation, because of prolonged exposure to aminoglycosides (AGs), chronic dehydration and complications of diabetes mellitus. The usual equations estimating the glomerular filtration rate (GFR), such as Cockcroft-Gault and Modification of Diet in Renal Disease, are not adapted to the CF population due to patients' low body weight and reduced muscle mass. The aim of this study was to precisely measure GFR in adult CF patients and to see whether repeated AG treatment would impair renal function before lung transplantation...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29682579/glomerular-filtration-rate-and-or-ratio-of-urine-albumin-to-creatinine-as-markers-for-diabetic-retinopathy-a-ten-year-follow-up-study
#6
Pedro Romero-Aroca, Marc Baget-Bernaldiz, Raul Navarro-Gil, Antonio Moreno-Ribas, Aida Valls-Mateu, Ramon Sagarra-Alamo, Joan F Barrot-De La Puente, Xavier Mundet-Tuduri
Aims: To determine the relationship between diabetic nephropathy and diabetic retinopathy on a population of type 2 diabetes mellitus patients. Methods: A prospective ten-year follow-up population-based study. We determined differences between estimated glomerular filtration rate (eGFR) using the chronic kidney disease epidemiology collaboration equation and urine albumin to creatinine ratio. Results: Annual incidence of any-DR was 8.21 ± 0...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29682152/thrombomodulin-as-a-new-marker-of-endothelial-dysfunction-in-chronic-kidney-disease-in-children
#7
Dorota Drożdż, Monika Łątka, Tomasz Drożdż, Krystyna Sztefko, Przemko Kwinta
Endothelial dysfunction (ED) and oxidative stress are potential new pathomechanisms of cardiovascular diseases in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk factors in children with CKD. Serum oxidized LDL (oxLDL), protein carbonyl group, urea, creatinine, cystatin C, thrombomodulin, asymmetric dimethylarginine (ADMA), von Willebrand factor, brain natriuretic peptide (BNP), lipids, high sensitivity C-reactive protein, intercellular adhesion molecule-1 levels, and albuminuria were measured...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29682097/growth-differentiation-factor-15-as-a-predictor-of-idiopathic-membranous-nephropathy-progression-a-retrospective-study
#8
Young Rok Ham, Chang Hun Song, Hong Jin Bae, Jin Young Jeong, Min-Kyung Yeo, Dae Eun Choi, Ki-Ryang Na, Kang Wook Lee
Idiopathic membranous nephropathy (IMN) is a major cause of nephrotic syndrome. No biomarker to predict the long-term prognosis of IMN is currently available. Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor- β superfamily and has been associated with chronic inflammatory disease. It has the potential to be a useful prognostic marker in patients with renal diseases, such as diabetic nephropathy and IgA nephropathy. This study examined whether GDF-15 is associated with the clinical parameters in IMN and showed that GDF-15 can predict IMN disease progression...
2018: Disease Markers
https://www.readbyqxmd.com/read/29681863/tangshen-formula-attenuates-diabetic-nephropathy-by-promoting-abca1-mediated-renal-cholesterol-efflux-in-db-db-mice
#9
Peng Liu, Liang Peng, Haojun Zhang, Patrick Ming-Kuen Tang, Tingting Zhao, Meihua Yan, Hailing Zhao, Xiaoru Huang, Huiyao Lan, Ping Li
The commonly prescribed Tangshen Formula (TSF) is a traditional Chinese formulation that has been shown to reduce plasma lipid metabolism and proteinuria and improve the estimated glomerular filtration rate (eGFR) in patients with diabetic kidney disease. This study investigated the underlying mechanism whereby TSF regulates renal lipid accumulation and ameliorates diabetic renal injuries in spontaneous diabetic db/db mice and in vitro in sodium palmitate (PA)-stimulated and Abca1-SiRNA-transfected mouse tubular epithelial cells (mTECs)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29680865/comparison-of-midterm-outcomes-of-transcatheter-aortic-valve-implantation-in-patients-with-and-without-previous-coronary-artery-bypass-grafting
#10
Hideyuki Kawashima, Yusuke Watanabe, Ken Kozuma, Akihisa Kataoka, Makoto Nakashima, Hirofumi Hioki, Fukuko Nagura, Yugo Nara, Shinichi Shirai, Norio Tada, Motoharu Araki, Toru Naganuma, Futoshi Yamanaka, Hiroshi Ueno, Minoru Tabata, Kazuki Mizutani, Akihiro Higashimori, Kensuke Takagi, Masanori Yamamoto, Kentaro Hayashida
The midterm safety and feasibility of transcatheter aortic valve implantation (TAVI) for patients with a history of coronary artery bypass graft (CABG) and high operative risk are unclear. This study compared the midterm outcomes of patients undergoing TAVI with or without previous CABG surgery. Between October 2013 and July 2016, 1,613 patients underwent TAVI according to the Optimized CathEter vAlvular iNtervention (OCEAN)-TAVI registry (previous CABG: n = 120; no previous CABG: n = 1493). The propensity score comprised the variables of the Society of Thoracic Surgeons Score, previous myocardial infarction, peripheral artery disease, chronic kidney disease > stage 2 (estimated glomerular filtration rate < 60 mL/min/1...
April 21, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29680822/disparities-in-the-estimation-of-glomerular-filtration-rate-according-to-cockcroft-gault-modification-of-diet-in-renal-disease-4-and-chronic-kidney-disease-epidemiology-collaboration-equations-and-relation-with-outcomes-in-patients-with-acute-coronary-syndrome
#11
José Miguel Rivera-Caravaca, Juan Miguel Ruiz-Nodar, Antonio Tello-Montoliu, María Asunción Esteve-Pastor, Miriam Quintana-Giner, Andrea Véliz-Martínez, Esteban Orenes-Piñero, Ana Isabel Romero-Aniorte, Nuria Vicente-Ibarra, Vicente Pernias-Escrig, Luna Carrillo-Alemán, Elena Candela-Sánchez, Ignacio Hortelano, Beatriz Villamía, Miriam Sandín-Rollán, Laura Nuñez-Martínez, Mariano Valdés, Francisco Marín
BACKGROUND: A simple method to assess renal function is the estimated glomerular filtration rate, and it shows prognostic implications. However, it remains unknown which equation should be used in patients with acute coronary syndrome. We compared the ability and correlation of the Cockcroft-Gault, Modification of Diet in Renal Disease-4 (MDRD-4), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations and their predictive performance for major adverse cardiovascular events, all-cause mortality, and major bleeding in a cohort of patients with acute coronary syndrome...
April 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29678805/mobile-health-to-maintain-continuity-of-patient-centered-care-for-chronic-kidney-disease-content-analysis-of-apps
#12
Ying-Li Lee, Yan-Yan Cui, Ming-Hsiang Tu, Yu-Chi Chen, Polun Chang
BACKGROUND: Chronic kidney disease (CKD) is a global health problem with a high economic burden, which is particularly prevalent in Taiwan. Mobile health apps have been widely used to maintain continuity of patient care for various chronic diseases. To slow the progression of CKD, continuity of care is vital for patients' self-management and cooperation with health care professionals. However, the literature provides a limited understanding of the use of mobile health apps to maintain continuity of patient-centered care for CKD...
April 20, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29678354/actin-dynamics-at-focal-adhesions-a-common-endpoint-and-putative-therapeutic-target-for-proteinuric-kidney-diseases
#13
REVIEW
Sanja Sever, Mario Schiffer
Proteinuria encompasses diverse causes including both genetic diseases and acquired forms such as diabetic and hypertensive nephropathy. The basis of proteinuria is a disturbance in size selectivity of the glomerular filtration barrier, which largely depends on the podocyte: a terminally differentiated epithelial cell type covering the outer surface of the glomerulus. Compromised podocyte structure is one of the earliest signs of glomerular injury. The phenotype of diverse animal models and podocyte cell culture firmly established the essential role of the actin cytoskeleton in maintaining functional podocyte structure...
April 17, 2018: Kidney International
https://www.readbyqxmd.com/read/29678268/development-of-a-screening-tool-to-predict-chronic-kidney-disease-risk-in-post-nephrectomy-living-kidney-donors
#14
J S Park, H K Ahn, J Na, H H Lee, Y E Yoon, M G Yoon, W K Han
Few studies have examined the long-term risks of kidney removal to donors despite the increase of frequency in kidney transplantation. This is the 1st study to develop prediction models of chronic kidney disease (CKD) for the 1-year period after donor nephrectomy in living donors. A prospective cohort of patients who underwent donor nephrectomy from March 1, 2006, to December 31, 2016, at the Severance Hospital, Seoul, South Korea, was used. CKD was defined as a glomerular filtration rate (GFR) <60 mL/min/1...
April 17, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29677110/dietary-treatment-of-metabolic-acidosis-in-chronic-kidney-disease
#15
REVIEW
Roswitha Siener
Chronic kidney disease and reduced glomerular filtration rate are risk factors for the development of chronic metabolic acidosis. The prevention or correction of chronic metabolic acidosis has been found to slow progression of chronic kidney disease. Dietary composition can strongly affect acid⁻base balance. Major determinants of net endogenous acid production are the generation of large amounts of hydrogen ions, mostly by animal-derived protein, which is counterbalanced by the metabolism of base-producing foods like fruits and vegetables...
April 20, 2018: Nutrients
https://www.readbyqxmd.com/read/29677050/changes-in-albuminuria-and-renal-outcome-in-patients-with-type-2-diabetes-and-hypertension-a-real-life-observational-study
#16
Francesca Viazzi, Antonio Ceriello, Paola Fioretto, Carlo Giorda, Pietro Guida, Giuseppina Russo, Eulalia Greco, Salvatore De Cosmo, Roberto Pontremoli
OBJECTIVES: To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). METHODS: Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimated glomerular filtration rate (eGFR) at baseline and regular visits during a 4-year period were retrieved and analyzed. We assessed the association between changes in albuminuria status during a 1-year baseline period and time updated blood pressure (BP) and eGFR loss over the subsequent 4-year follow-up...
April 19, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29676999/sex-differences-in-transcriptomic-profiles-in-aged-kidney-cells-of-renin-lineage
#17
Yuliang Wang, Diana G Eng, Jeffrey W Pippin, Sina A Gharib, Aaron McClelland, Kenneth W Gross, Stuart J Shankland
Renin expressing cells in the kidney's juxta-glomeruluar compartment likely also serve as progenitors for adult glomerular cells in disease. Although these cells of renin lineage (CoRL) decrease in number with advancing kidney age, accompanied by less responsiveness to typical stimuli such as ACE-inhibition, mechanisms and the impact of sex as a biological variable with age are not known. Accordingly, labeled CoRL were sorted from individual young (2m) and aged (27m) male and female Ren1cCre|ZsGreen reporter mice, and their transcriptomic profiles analyzed by RNA seq...
April 18, 2018: Aging
https://www.readbyqxmd.com/read/29676846/generic-sofosbuvir-based-direct-acting-antivirals-in-hepatitis-c-virus-infected-patients-with-chronic-kidney-disease
#18
Manoj Kumar Sharma, Suman Lata Nayak, Ekta Gupta, Ashish Kataria, Shiv K Sarin
BACKGROUND & AIMS: There is scant data on use of sofosbuvir containing directly acting anti-viral (DAA) regimens in chronic kidney disease (CKD) patients. Recently generic versions of DAAs have become available in low income countries including India. The aim of this study was to study the efficacy and safety of generic sofosbuvir in combination with generic ribavirin, ledipasvir, or daclatasvir in HCV infected patients with CKD including patients with advanced CKD (CKD stage 4 or 5 with an estimated glomerular filtration rate (GFR) <30 mL/min or those on dialysis)...
April 20, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29676622/low-to-moderate-arsenic-exposure-and-respiratory-health-in-american-indian-communities
#19
Martha Powers, Tiffany R Sanchez, Maria Grau-Perez, Fawn Yeh, Kevin Francesconi, Walter Goessler, Christine M George, Christopher Heaney, Lyle G Best, Jason Umans, Robert H Brown, Ana Navas-Acien
RATIONALE: Exposure to inorganic arsenic, through drinking naturally-contaminated water, is an established cause of lung cancer. Evidence on the impact of arsenic exposure on lung function, however, is less conclusive. The evidence available, mostly from populations exposed to water arsenic levels >100 μg/L, suggests that arsenic exposure is associated with lower lung function. Prospective studies and studies examining low-to-moderate levels of water arsenic exposure (<50 μg/L) the level relevant for U...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29674631/orally-active-species-independent-novel-a-3-adenosine-receptor-antagonist-protects-against-kidney-injury-in-db-db-mice
#20
Debra Dorotea, Ahreum Cho, Gayoung Lee, Guideock Kwon, Junghwa Lee, Pramod K Sahu, Lak Shin Jeong, Dae Ryong Cha, Hunjoo Ha
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, and the current pharmacological treatment for DKD is limited to renin-angiotensin system (RAS) inhibitors. Adenosine is detectable in the kidney and is significantly elevated in response to cellular damage. While all 4 known subtypes of adenosine receptors, namely, A1 AR, A2a AR, A2b AR, and A3 AR, are expressed in the kidney, our previous study has demonstrated that a novel, orally active, species-independent, and selective A3 AR antagonist, LJ-1888, ameliorates unilateral ureteral obstruction-induced tubulointerstitial fibrosis...
April 20, 2018: Experimental & Molecular Medicine
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