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Sarcoidosis

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https://www.readbyqxmd.com/read/29681578/spontaneous-reduction-in-abnormal-myocardial-uptake-of-fluorine-18-fluorodeoxygluose-in-a-patient-with-cardiac-sarcoidosis
#1
Fumio Terasaki, Shu-Ichi Fujita, Yumiko Kanzaki, Yoshinobu Hirose, Nobukazu Ishizaka
Fluorine-18 fluorodeoxygluose (18 F-FDG) positron emission tomography (PET) is a useful tool for evaluating disease activity in sarcoidosis including cardiac involvement. A 67-year-old patient who developed atrioventricular block requiring permanent pacemaker implantation was diagnosed with cardiac sarcoidosis. The patient did not undergo steroid or immunosuppressive therapy but underwent serial 18 F-FDG PET examination, which showed spontaneous reduction in the myocardial FDG uptake, indicating the remission of immune-inflammatory activity...
April 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29679363/proangiogenic-and-profibrotic-markers-in-pulmonary-sarcoidosis
#2
I Tuleta, L Biener, C Pizarro, G Nickenig, D Skowasch
The aim of our study was to determine the blood levels of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, fibroblast growth factor (FGF)-2, and platelet-derived growth factor (PDGF)-AB in different stages of pulmonary sarcoidosis. There were 92 patients in sarcoidosis stages I + II, III, and IV enrolled into the study. All the patients underwent lung diffusing capacity and blood sampling. We found that VEGF levels differed significantly between the stage groups with the peak VEGF concentrations in stage III...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29678394/-dermatologic-toxicities-of-immune-checkpoint-inhibitors
#3
REVIEW
V Sibaud, S Boulinguez, C Pagès, L Riffaud, L Lamant, C Chira, S Boyrie, E Vigarios, E Tournier, N Meyer
The development of immune checkpoint inhibitors (monoclonal antibodies targeting PD-1/PD-L1 or CTLA-4) represents a significant advance in the treatment of multiple cancers. Given their particular mechanism of action, which involves triggering CD4+/CD8+ T-cell activation and proliferation, they are associated with a specific safety profile. Their adverse events are primarily immune-related, and can affect practically all organs. In this context, dermatological toxicity is the most common, though it mostly remains mild to moderate and does not require discontinuation of treatment...
April 17, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29675060/utility-and-safety-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-patients-with-mediastinal-and-hilar-lymphadenopathy-western-region-experience
#4
Ahmed A Aljohaney
AIMS: The aim of the study was to evaluate the clinical utility and safety of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with mediastinal and hilar lymphadenopathy and to explicitly describe the utility of this procedure in patient's outcome. METHODS: A retrospective review and analysis was conducted on 52 patients with mediastinal or hilar lymphadenopathy who underwent EBUS-TBNA from June 2012 to June 2016. All the patients were evaluated by computed tomography (CT) chest with contrast before EBUS examination...
April 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29671151/an-atypical-case-of-neurosarcoidosis-presenting-with-neovascular-glaucoma
#5
REVIEW
Melissa Vereecken, Karolien Hollanders, Deborah De Bruyn, Virginie Ninclaus, Julie De Zaeytijd, Ilse De Schryver
BACKGROUND: Sarcoidosis, a multisystem, granulomatous disorder, sometimes manifests with a neuro-ophthalmic subtype. The latter can pose a diagnostic challenge, especially when ocular symptoms appear before systemic involvement, as the clinical picture then can be non-specific and systemic laboratory and standard imaging investigations can be negative. FINDINGS: A 71-year-old woman presented with a 4-month history of sudden-onset visual loss in the left eye. Slit lamp examination revealed anterior chamber cells, iris, and angle neovascularization...
April 18, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29670497/comparing-the-differential-diagnostic-values-of-18-f-alfatide-ii-pet-ct-between-tuberculosis-and-lung-cancer-patients
#6
Xiaoqing Du, Yu Zhang, Liping Chen, Baoming Mi, Qingjun You, Yuping Xu, Donghui Pan, Weixing Wan, Min Yang, Chunjing Yu
Purpose: To compare the differential diagnostic values of 18 F-Alfatide II PET/CT between tuberculosis and lung cancer patients and in patients with sarcoidosis and common inflammation. Methods: Nine inflammation patients (4 tuberculosis, 3 sarcoidosis, and 2 common inflammation) and 11 lung cancer patients were included in this study. All patients underwent 18 F-FDG and 18 F-Alfatide II PET/CT within 2 weeks, followed by biopsy and surgery. The maximized standard uptake value (SUVmax) and the mean standard uptake value (SUVmean) were evaluated...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29667945/pulmonary-sarcoidosis-induced-by-anti-tumor-necrosis-factor-therapy-a-paradoxical-effect
#7
Alisson Aliel Vigano Pugliesi, Rachel Zerbini Mariano, Camila Matsunaga De Angelis, Manoel Barros Bertolo, Michel Alexandre Yazbek
No abstract text is available yet for this article.
April 5, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29666703/sarcoid-like-mediastinal-lymphadenopathy-in-gynecologic-malignancy
#8
Bilal H Lashari, Megumi Asai, Gissele Randleman, Martha Sack, Rajeshkumar Patel
Noncaseating granulomas are seen surrounding tumors with varying frequency, possibly as part of an immune response to tumor cells. However, data about the association of sarcoid with gynecologic malignancy is sparse. We performed a search of our institutional database for all EBUS-TBNA biopsies conducted within the past five years that revealed granulomatous inflammation. All adult female patients with a history of gynecologic malignancy were included. Patients with a history of sarcoidosis or fungal or mycobacterial infection were excluded...
2018: Pulmonary Medicine
https://www.readbyqxmd.com/read/29663152/a-glimpse-into-uveitis-in-the-aging-eye-pathophysiology-clinical-presentation-and-treatment-considerations
#9
REVIEW
Elizabeth Akinsoji, Raquel Goldhardt, Anat Galor
Uveitis describes a group of inflammatory conditions of the eye that have various underlying causes and clinical presentations. Susceptibilities to uveitis in the elderly may be attributed to age-related risk factors such as immunosenescence, increased immunological inflammatory mediators, and autoimmunity. Overall, anterior uveitis is more common than posterior and panuveitis in the general population and also in the elderly. Some causes of uveitis in the elderly are herpes simplex virus, ocular ischemic syndrome, sarcoidosis, and central nervous system lymphoma, and these will be discussed in detail herein...
April 16, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29655487/frequency-of-aquaporin-4-immunoglobulin-g-in-longitudinally-extensive-transverse-myelitis-with-antiphospholipid-antibodies
#10
Hilda Guerra, Sean J Pittock, Kevin G Moder, James P Fryer, Avi Gadoth, Eoin P Flanagan
Antiphospholipid (aPL) antibodies have historically been postulated to cause a poorly understood inflammatory myelitis. Neuromyelitis optica spectrum disorder (NMOSD) causes an inflammatory longitudinally extensive transverse myelitis (LETM). In 2004, aquaporin-4 immunoglobulin G (AQP4-IgG) was first reported as a highly specific (>99%) serum diagnostic biomarker of NMOSD, distinguishing it from other disorders (eg, multiple sclerosis). We sought to assess the frequency of AQP4-IgG (and thus NMOSD diagnosis) in LETM with aPL antibodies...
April 11, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29650028/a-rare-presentation-of-pulmonary-sarcoidosis-as-a-solitary-lung-mass-a-case-report
#11
Dylan W Kelleher, Madeleine Yaggi, Robert Homer, Erica L Herzog, Changwan Ryu
BACKGROUND: Sarcoidosis is a multisystem, chronic granulomatous disease of unknown etiology that predominantly affects the lungs. Pulmonary sarcoidosis classically presents with constitutional symptoms and computed tomographic scan findings of bilateral, symmetric micronodules in a peribronchovascular distribution with upper and middle lung zone predominance accompanied by bilateral, symmetric hilar lymphadenopathy. A solitary lung mass is a rare finding for pulmonary sarcoidosis, and with its associated constitutional symptoms, it strongly mimics a malignancy...
April 13, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29644445/-perioperative-onset-of-sarcoidosis-rare-differential-diagnosis-of-a-difficult-airway
#12
G Jansen, A Nowak
Sarcoidosis is a rare multisystemic chronic inflammatory condition. Typically, there is a big discrepancy between the patient's subjectively perceived symptoms and the presence of clinical signs. Due to the high number of potential sites of onset (e. g. larynx, lungs, heart, liver, kidneys) the affected organs may show functional restrictions that are relevant for decisions related to anesthesia. Therefore, an anesthetists working in a clinical setting should be familiar with the special needs of this patient collective...
April 11, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29644199/granuloma-annulare-skin-lesions-in-a-case-of-sarcoidosis
#13
Ajay Chopra, Debdeep Mitra, Loknandini Sharma, Reetu Agarwal
We report the case of a 32-year- old man with a short 3-week history of erythematous, annular, non scaly plaques on palmar and dorsal aspect of his hands, who was concurrently diagnosed as a case of sarcoidosis on the basis of findings of generalized lymphadenopathy and radiological and histological features of pulmonary sarcoidosis. His skin biopsy was consistent with the diagnosis of granuloma annulare. Sarcoidosis and granuloma annulare are two separate diseases, which involve the skin and have a mononuclear histiocytic cellular reaction, although their aetiology is still unknown...
March 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29643679/a-rare-case-of-sarcoidosis-presenting-as-diffuse-contracturing-granulomatous-myositis-on-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#14
Krishnadas Thulasidoss, Sowmya Sridharan, Lavanya Ashokan, Piyush Chandra
Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is an established imaging modality in diagnosis and treatment response monitoring of sarcoidosis. Multisystemic involvement of sarcoidosis is characteristically seen on PET/CT; however, isolated organ involvement is rare. We describe here a case of a 52-year-old male with generalized muscle weakness, an extremely rare clinical manifestation of sarcoidosis.
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29630082/pulmonary-hydatid-disease-with-aspergillosis-an-unusual-association-in-an-immunocompetent-host
#15
Rahul Chanderhas Goyal, Ruchita Tyagi, Bhavna Garg, Atul Mishra, Neena Sood
Echinococcosis is a common cause of pulmonary cavities. Aspergillus fumigatus, a saprophytic fungus, can colonise pulmonary cavities caused by tuberculosis, sarcoidosis, echinococcosis, bronchiectasis and neoplasms. Infection by Aspergillus is often seen in immunosuppressed cases. However, co-infection of Aspergillus with pulmonary echinococcosis is unexpected and very unusual, especially in an immunocompetent patient. We present the case of a 45-year-old immunocompetent male who came with non-resolving pneumonia and fever for 8 months and dyspnoea since 15 days accompanied by recurrent episodes of hemoptysis since 5 days...
April 9, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29628471/a-case-of-a-cardiac-resynchronization-therapy-defibrillator-exhibiting-a-lower-and-alternately-variable-basic-rate
#16
Keigo Iwazaki, Toshiya Kojima, Takahide Murasawa, Jun Yokota, Hikaru Tanimoto, Jun Matsuda, Nobuaki Fukuma, Takumi Matsubara, Yu Shimizu, Gaku Oguri, Eriko Hasumi, Hitoshi Kubo, Kyungho Chang, Katsuhito Fujiu, Issei Komuro
A cardiac resynchronization therapy defibrillator (CRT-D) (Medtronic Inc. Protecta XT) was implanted in a 67-year-old man who had cardiac sarcoidosis with extremely low cardiac function. He had ventricular tachycardia which was controlled by catheter ablation, medication and pacing. The programmed mode was DDI, lower rate was 90 beats/minute, paced AV delay was 150 ms, and the noncompetitive atrial pacing (NCAP) function was programmed as 300 ms.After his admission for pneumonia and heart failure, we changed his DDI mode to a DDD mode because he had atrial tachycardia, which led to inadequate bi-ventricular pacing...
April 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29628134/sleep-disturbance-and-symptom-burden-in-sarcoidosis
#17
Bryan S Benn, Zoe Lehman, Sharon A Kidd, Christine Miaskowski, Bernie Y Sunwoo, Melissa Ho, Sara Sun, Joris Ramstein, Jeffrey M Gelfand, Laura L Koth
INTRODUCTION: Sarcoidosis is a systemic inflammatory disease associated with myriad symptoms, including fatigue. It can affect physiological processes like sleep, leading to poor sleep quality and excessive daytime sleepiness. We hypothesized that sarcoidosis patients would report more severe sleep disturbance than healthy controls and that relationships would be found with sleep disturbance and the severity of other symptoms. METHODS: We enrolled 84 sarcoidosis patients and 30 healthy controls and recorded demographic and clinical characteristics...
March 24, 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29626942/nuclear-imaging-in-sarcoidosis
#18
REVIEW
Eve Piekarski, Khadija Benali, François Rouzet
Sarcoidosis is a multisystem granulomatosis which may result in a wide variety of clinical and biological presentations. Symptoms are often nonspecific, and incidental abnormal findings on chest radiography is rather common. Although sarcoidosis resolves favorably in most cases, some localizations can provoke functional impairment or even impact on patients' prognosis. The diagnosis is based on a pathological hallmark which is the non-necrotizing epithelioid-cell rich granuloma. Owing to the ability to detect inflammation throughout the body with a high sensibility, FDG-PET/CT gained a central role in sarcoidosis because it can suggest the diagnosis in certain clinical context, guide biopsy, evaluate the extent of the disease, help assess the prognosis, and monitor immunosuppressive therapy...
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29626941/imaging-macrophage-associated-inflammation
#19
REVIEW
Catherine A Foss, Julian Sanchez-Bautista, Sanjay K Jain
Macrophages belong to the mononuclear phagocyte system comprising closely related cells of bone marrow origin. Activated macrophages are critical in several diseases such as tuberculosis, sarcoidosis, Crohn's disease, and atherosclerosis. Noninvasive imaging techniques that can specifically image activated macrophages could therefore help in differentiating various forms of inflammatory diseases and to monitor therapeutic responses.
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29626017/systemic-inflammatory-disorders-in-patients-admitted-for-aseptic-meningitis
#20
Marine Boudot de la Motte, Rachid Abbas, Fanny Jouan, Damien van Gysel, Marie Paule Chauveheid, Thomas Papo, Karim Sacre
Acute meningitis can be the first manifestation of an underlying systemic inflammatory disorder (SID). In the current study, we aimed to identify clinical indicators for SIDs in patients admitted for acute aseptic meningitis. All patients hospitalised for acute aseptic meningitis over a 4-year period in a department of internal medicine were included retrospectively. Patients with neoplastic meningitis were excluded. Extraneurological signs were recorded using a systematic panel. Systemic inflammatory disorder diagnosis was made according to current international criteria...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
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