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Paola U Facco, Michele Baziotti Man, Cristiane Martin, Angelo Sementilli, Luiza F Rocha, Maria Celia C Ciaccia, José Roberto P Almeida, Sandra Dinato, Paola Vendramini, Ellen O Dantas, Nuria Zurro, Antonio Condino-Neto, Vera E V Rullo
The original version of abstract PO-162 "Chronic Granulomatous Disease in a Brazilian Patient Mimetizing Sarcoidosis" incorrectly listed the name of the second author as Micheli Barsioti. The correct spelling of the author's name is Michele Baziotti Man.
February 22, 2018: Journal of Clinical Immunology
Amika K Sood, William Funkhouser, Brian Handly, Brent Weston, Eveline Y Wu
PURPOSE OF REVIEW: Granulomatous-lymphocytic interstitial lung disease (GLILD) has classically been associated with common variable immune deficiency (CVID), but is increasingly being reported in other immunodeficiencies. We describe the second reported case of GLILD in a patient with 22q11.2 deletion syndrome (22q11.2DS) and review the recent literature surrounding GLILD. RECENT FINDINGS: GLILD is characterized by granulomata and lymphoproliferation. Consensus statements and retrospective and case-control studies have better elucidated the clinicopathological and radiographic manifestations of GLILD, allowing for its differentiation from similar conditions like sarcoidosis...
February 22, 2018: Current Allergy and Asthma Reports
Felipe Benavente-Villegas, Tania Díaz-Corpas, María García-Briz, Lya Moneva-Léniz, José Sánchez-Motilla, Amelia Prats-Máñez, Amparo Fuertes-Prosper, Pilar Soriano-Sarrió
La práctica de tatuajes tienen más de 8000 años de antigüedad, existiendo un incremento continuo en la sociedad occidental en las últimos 3 décadas La introducción de una sustancia exógena en la pielpuede provocar una respuesta inmunológica en su contra, estando descritas reacciones cutáneas por hipersensibilidad a una variedad de pigmentos, las que se limitan al área de un determinado color,atribuyéndose a los materiales inyectados. El color más reportado en la literatura es el rojo, que tradicionalmente se confeccionaban a base dederivados del mercurio (cinabrio)...
January 15, 2018: Dermatology Online Journal
Sentaro Kusuhara, Atsuko Katsuyama, Wataru Matsumiya, Makoto Nakamura
PURPOSE: The purpose of this study was to describe the initial experience, efficacy, and safety of ripasudil hydrochloride hydrate (ripasudil), a Rho-associated kinase inhibitor eye drop, for uveitic glaucoma. METHODS: In this retrospective case series, we retrieved the clinical data of 21 eyes from 19 patients with open-angle uveitic glaucoma who were treated with ripasudil at Kobe University Hospital. We analyzed the median intraocular pressure (IOP) reductions after ripasudil treatment and collected the information on the adverse events that were encountered during the course of this treatment period...
February 21, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Marios Rossides, Susanna Kullberg, Johan Askling, Anders Eklund, Johan Grunewald, Elizabeth V Arkema
We aimed to investigate sarcoidosis mortality in a large, population-based cohort, taking into account disease heterogeneity.Individuals with incident sarcoidosis (n=8207) were identified from the Swedish National Patient Register using International Classification of Disease codes (2003‒2013). In a subset, cases receiving treatment ±3 months from diagnosis were identified from the Prescribed Drug Register. Nonsarcoidosis comparators from the general population were matched to cases 10:1 on birth year, sex and county...
February 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Josiane V Cruz, Moysés F A Neto, Luciane B Silva, Ryan da S Ramos, Josivan da S Costa, Davi S B Brasil, Cleison C Lobato, Glauber V da Costa, José Adolfo H M Bittencourt, Carlos H T P da Silva, Franco H A Leite, Cleydson B R Santos
The Protein Kinase Receptor type 2 (RIPK2) plays an important role in the pathogenesis of inflammatory diseases; it signals downstream of the NOD1 and NOD2 intracellular sensors and promotes a productive inflammatory response. However, excessive NOD2 signaling has been associated with various diseases, including sarcoidosis and inflammatory arthritis; the pharmacological inhibition of RIPK2 is an affinity strategy that demonstrates an increased expression of pro-inflammatory secretion activity. In this study, a pharmacophoric model based on the crystallographic pose of ponatinib, a potent RIPK2 inhibitor, and 30 other ones selected from the BindingDB repository database, was built...
February 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Or Carmi, Maya Berla, Evgeny Edelstein, Yair Levy
No abstract text is available yet for this article.
February 14, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Jens Vikse, Stein Ørn, Bas Jeroen de Romijn, Ole Jacob Greve, Katrine Brække Norheim
Sarcoidosis is characterised by granulomatous inflammation in one or more organs, including the heart. Cardiac sarcoidosis generally has non-specific symptoms, and the disease is often diagnosed at a late stage. The condition is associated with cardiomyopathy and arrhythmia and may be fatal.
February 19, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Dominika Pohlmann, Gerrit A Vom Brocke, Sibylle Winterhalter, Theresa Steurer, Sabrina Thees, Uwe Pleyer
PURPOSE: To report the effectiveness of repeated intravitreal dexamethasone (DEX) inserts in noninfectious uveitis patients. DESIGN: Prospective, single-center, interventional clinical trial between February 2010 and March 2015. PARTICIPANTS: Patients with noninfectious uveitis with cystoid macular edema and/or vitreitis. METHODS: Patients were treated with a 700-μg intravitreal DEX insert (Ozurdex; Allergan, Inc., Irvine, CA)...
February 16, 2018: Ophthalmology
Carolina Muñoz, Mauricio Restrepo-Escobar, Manuel Martínez-Muñoz, Andrés Echeverri, Javier Márquez, Luis Fernando Pinto
INTRODUCTION: Sarcoidosis is a complex disease of unknown etiology, with a variable course and highly different forms of presentation. Our objective was to characterize all our patients with sarcoidosis with emphasis on their clinical presentation and to establish differences between patients with sarcoidosis with and without joint involvement. METHODS: We reviewed the medical records of all patients with a diagnosis of sarcoidosis who were treated at the outpatient or inpatient services of the Pablo Tobón Uribe Hospital in Medellín, Colombia, from January 2002 to April 2017...
February 15, 2018: Reumatología Clinica
Iris Deitch, Radgonde Amer, Oren Tomkins-Netzer, Zohar Habot-Wilner, Ronit Friling, Ron Neumann, Michal Kramer
PURPOSE: This study aimed to report the clinical outcome of children with uveitis treated with anti-tumor necrosis factor alpha (TNF-α) agents. METHODS: This included a retrospective cohort study. Children with uveitis treated with infliximab or adalimumab in 2008-2014 at five dedicated uveitis clinics were identified by database search. Their medical records were reviewed for demographic data, clinical presentation, ocular complications, and visual outcome. Systemic side effects and the steroid-sparing effect of treatment were documented...
February 18, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
W Ennis James, Efstratios Koutroumpakis, Biplab Saha, Alireza Nathani, Leahruth Saavedra, Recai M Yucel, Marc A Judson
BACKGROUND: Compared to pulmonary sarcoidosis, sarcoidosis without lung involvement may involve other immunopathologic mechanisms and be associated with other demographic and clinical features. METHODS: This was a retrospective analysis of clinical data collected in real time on 1,686 patients with biopsy-proven sarcoidosis from two large university sarcoidosis outpatient clinics in the United States. We compared differences in demographics characteristics and clinical presentation between pulmonary and non-pulmonary sarcoidosis (NPS)...
February 14, 2018: Chest
Cheng-Wei Li, Ru-Jia Tao, Dan-Feng Zou, Man-Hui Li, Xin Xu, Wei-Jun Cao
OBJECTIVES: Sarcoidosis is a multisystem disease characterised by the formation of granulomas within various organs, mainly the lungs. Several studies from different countries have been undertaken to investigate sarcoidosis with extrapulmonary involvement except from China. The objective of this study is to investigate a comparative clinical analysis in patients with pulmonary sarcoidosis with and without extrapulmonary involvement from China. METHODS: Data from inpatients diagnosed with sarcoidosis at Shanghai Pulmonary Hospital (Shanghai, China) between January 2009 and December 2014 were retrospectively collected and analysed...
February 16, 2018: BMJ Open
G Broggi, E Reggio, L Giuliano, S Palmucci, R Caltabiano, S Lanzafame
Sarcoidosis is a multisystemic granulomatous disease characterized by the presence of noncaseating granulomas, the exact etiology of which is yet to be determined. Most of patients show granulomas located in the lungs or in the related lymph nodes. However, lesions can affect any organ. Noncaseating granulomas are not a pathognomonic sign of sarcoidosis, being observed also in other diseases, therefore the diagnosis is often of exclusion. We report a case of sarcoidosis with parotid gland involvement in the context of a Heerfordt syndrome, discussing about its clinical presentation, pathogenesis, pathology and differential diagnosis with other granulomatous diseases...
December 2017: Pathologica
Caroline E Broos, Laura L Koth, Menno van Nimwegen, Johannes C C M In't Veen, Sandra M J Paulissen, Jan Piet van Hamburg, Jouke T Annema, Roxane Heller-Baan, Alex Kleinjan, Henk C Hoogsteden, Marlies S Wijsenbeek, Rudi W Hendriks, Bernt van den Blink, Mirjam Kool
Objective: The lung-draining mediastinal lymph nodes (MLN) are currently widely used to diagnose sarcoidosis. We previously reported that T helper 17.1 (Th17.1) cells are responsible for the exaggerated IFN-γ production in sarcoidosis lungs. In this study, we aimed to investigate (i) whether Th17.1 cells are also increased in the MLN of sarcoidosis patients, and (ii) whether frequencies of the Th17.1 cells at diagnosis may correlate with disease progression. Methods: MLN cells from treatment-naive pulmonary sarcoidosis patients (n=17) and healthy controls (n=22) and peripheral blood (PB) mononuclear cells (n=34) and broncho-alveolar lavage fluid (BALF) (n=36) from sarcoidosis patients were examined for CD4 + T cell subset proportions, using flow cytometry...
February 15, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Brooke Crawford, Fadi Badlissi, Santiago A Lozano Calderón
Advanced imaging has demonstrated that musculoskeletal manifestations of systemic sarcoidosis are more common than previously thought. A definitive strategy for the management of osseous sarcoidosis has not been defined. Some lesions resolve spontaneously, and no systemic medication for sarcoidosis consistently resolves lesions. The orthopaedic surgeon treating patients with musculoskeletal sarcoidosis must make an appropriate diagnosis of bony lesions, seek multidisciplinary input from specialists in pulmonology and rheumatology regarding systemic treatment, and decide when surgery is necessary to prevent dysfunction...
February 13, 2018: Journal of the American Academy of Orthopaedic Surgeons
P Chauhan, D Meena, N Hazarika
No abstract text is available yet for this article.
January 2018: Indian Dermatology Online Journal
Marwa A Mohamed, Ehab I Mohamed, Samir A Abd El-Kaream, Mohamed I Badawi, Samy H Darwish
BACKGROUND: Evidence is increasing that microRNAs (miR) are particularly important in lung homeostasis and development and have been shown to be involved in many pulmonary diseases such as asthma, chronic obstructive pulmonary disease, sarcoidosis, lung cancer (LC) and other smoking-related diseases. OBJECTIVE: The objective of this study was to investigate the expression of miR-155 and miR-486-5p in tissues from LC patients and healthy endobronchial mucosa as prognostic biomarkers for diagnosing LC...
February 12, 2018: MicroRNA
Shalabh Arora, Alice Joan Mathuram
No abstract text is available yet for this article.
October 2017: Indian Journal of Medical Research
David M Clive, Vijay K Vanguri
The syndrome of tubulointerstitial nephritis and uveitis (TINU) is a multisystemic autoimmune disorder that may occur in response to various environmental triggers, including drugs and microbial pathogens. Evidence exists of HLA antigen-related genetic predisposition to developing TINU. The resulting inflammation affects chiefly the ocular uvea and renal tubules, although other organs may be involved. TINU is uncommon; only about 200 cases are on record since its original description 40 years ago, although it is possible that new ones are no longer being reported...
February 8, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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