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Sarcoidosis

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https://www.readbyqxmd.com/read/29053026/application-of-omics-and-systems-biology-to-sarcoidosis-research
#1
Elliott D Crouser, Tasha E Fingerlin, Ivana V Yang, Lisa A Maier, Patrick Nana-Sinkam, Ronald G Collman, Naftali Kaminski
Sarcoidosis is a complex, polygenic disease of unknown cause with diverse clinical phenotypes, ranging from self-limited, asymptomatic disease to life altering symptoms and early disease-related mortality. It is unlikely that a single common environmental exposure (e.g., infection, antigen) entirely explains the disease, and numerous genetic mutations are associated with the disease. As such, it reasonable to assume, as with other phenotypically diverse diseases, that distinct genetic mechanisms and related biological biomarkers will serve to further define sarcoidosis sub-phenotypes and mechanisms and to guide personalized care...
October 20, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29052709/association-of-prognostic-factors-and-immunosuppressive-treatment-with-long-term-outcomes-in-neurosarcoidosis
#2
Bastien Joubert, Catherine Chapelon-Abric, Lucie Biard, David Saadoun, Sophie Demeret, Didier Dormont, Matthieu Resche-Rigon, Patrice Cacoub
Importance: Prognostic factors are lacking in neurosarcoidosis (NS), and the association of immunosuppressive treatments with outcomes are unclear. Objectives: To identify prognostic factors of and analyze the association of immunosuppressive treatment with relapse of NS. Design, Setting, and Participants: In this retrospective study, a cohort of 234 patients fulfilled the diagnostic criteria for NS in a tertiary referral center in Paris, France, from January 1, 1990, through December 31, 2015...
October 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29052526/cardiac-magnetic-resonance-imaging-indeterminate-negative-cardiac-sarcoidosis-revealed-by-18-f-fluorodeoxyglucose-positron-emission-tomography-two-case-reports-and-a-review-of-the-literature
#3
S C Sasson, R Russo, T Chung, G Chu, I Hunyor, J Williamson, A Murad, A Kane, S Riminton, S Limaye
BACKGROUND: Sarcoidosis is an inflammatory disorder of immune dysregulation characterized by non-caseating granulomas that can affect any organ. Cardiac sarcoidosis is an under-recognized entity that has a heterogeneous presentation and may occur independently or with any severity of systemic disease. Diagnosing cardiac sarcoidosis remains problematic with endomyocardial biopsies associated with a high risk of complications. Several diagnostic algorithms are currently available that rely on histopathology or clinical and radiological measures...
October 20, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29051345/reply-utilizing-and-interpreting-fdg-pet-ct-images-in-patients-referred-for-assessment-of-cardiac-sarcoidosis-the-devil-is-in-the-details
#4
David Birnie, Hiroshi Ohira, Rob Beanlands
No abstract text is available yet for this article.
October 19, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29051277/treatment-of-sarcoidosis-associated-pulmonary-hypertension-so-close-and%C3%A2-yet-so-far
#5
EDITORIAL
Robert P Baughman, Oksana A Shlobin
No abstract text is available yet for this article.
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29051269/management-and-long-term-outcomes-of-sarcoidosis-associated-pulmonary-hypertension
#6
Athénaïs Boucly, Vincent Cottin, Hilario Nunes, Xavier Jaïs, Abdelatif Tazi, Grégoire Prévôt, Martine Reynaud-Gaubert, Claire Dromer, Catherine Viacroze, Delphine Horeau-Langlard, Christophe Pison, Emmanuel Bergot, Julie Traclet, Jason Weatherald, Gérald Simonneau, Dominique Valeyre, David Montani, Marc Humbert, Olivier Sitbon, Laurent Savale
Studies reporting the effects of modern strategies with pulmonary arterial hypertension (PAH)-targeted therapies in sarcoidosis-associated pulmonary hypertension (S-APH) are limited.Clinical and haemodynamic data from newly diagnosed patients with severe S-APH (mean pulmonary artery pressure (mPAP) >35 mmHg or mPAP 25-35 mmHg with cardiac index <2.5 L·min(-1)·m(-2)) were collected from the French Pulmonary Hypertension Registry between 2004 and 2015.Data from 126 patients with severe S-APH were analysed (mean±sd age 57...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29051105/nicotine-and-autoimmunity-the-lotus-flower-in-tobacco
#7
REVIEW
João Pedro Gomes, Abdulla Watad, Yehuda Shoenfeld
Nicotine, the major component of cigarettes, has demonstrated conflicting impact on the immune system: some authors suggest that increases pro-inflammatory cytokines and provokes cellular apoptosis of neutrophils, releasing intracellular components that act as auto-antigens; others claimed that nicotine has a protective and anti-inflammatory effects, especially by binding to α7 subunit of nicotinic acetylcholine receptors. The cholinergic pathway contributes to an anti-inflammatory environment characterized by increasing T regulatory cells response, down-regulating of pro-inflammatory cytokines and a pro-inflammatory cells apoptosis...
October 16, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29050132/-the-timing-and-prognosis-of-lung-transplantation-for-chronic-sarcoidosis
#8
X Q Ma, H P Dai, C Wang
No abstract text is available yet for this article.
October 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29048937/executive-summary-of-the-nhlbi-workshop-report-leveraging-current-scientific-advances-to-better-understand-sarcoidosis-variability-and-improve-outcomes
#9
Lisa A Maier, Elliott D Crouser, William J Martin, Jerry Eu
Sarcoidosis is a systemic granulomatous disease that primarily affects the lung; it is associated with significant disparities, more commonly impacting those in the prime of their lives, age 20-50, with a second peak after age 60, Blacks, and women. However, the burden of disease, the ability to diagnose and prognose organ involvement and course, as well as specific treatment and management options, and disease pathogenesis remain poorly understood. As a result, the National Heart Lung and Blood Institute (NHLBI) undertook a sarcoidosis workshop "Leveraging Current Scientific Advancements to Understand Sarcoidosis Variability and Improve Outcomes" to help address these issues by defining the scientific and clinical priorities to improve sarcoidosis care...
October 19, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29046979/medical-management-of-pulmonary-hypertension-with-unclear-and-or-multifactorial-mechanisms-group-5-is-there-a-role-for-pulmonary-arterial-hypertension-medications
#10
REVIEW
Jason Weatherald, Laurent Savale, Marc Humbert
PURPOSE OF REVIEW: The purpose of this review was to outline the mechanisms and to review recent literature on pulmonary arterial hypertension (PAH) medications in group 5 pulmonary hypertension (PH). RECENT FINDINGS: The first steps in management are to understand the mechanisms and hemodynamic profile and to exclude chronic thromboembolic disease. Recent studies in the past 5 years have found that PAH medications may improve hemodynamics in patients with pre-capillary pulmonary hypertension due to sarcoidosis, pulmonary Langerhans cell histiocytosis, lymphangioleiomyomatosis, and myeloproliferative disorders with dasatinib-induced PH...
October 18, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/29046010/-differential-diagnosis-of-mediastinal-and-hilar-lymphadenopathy-with-focus-on-occupational-diseases
#11
H Lux, L Barreira Cavalcante, X Baur
Hilar and mediastinal lymphadenopathy may represent a diagnostic challenge in clinical practice. This article is intended to facilitate differential diagnosis by a systematic description of relevant pathologies, notably with occupational etiology. Clinical findings of relevant diseases, i. e. of tuberculosis, chronic beryllium disease, sarcoidosis, lung cancer, malignant lymphoma, Epstein-Barr virus infection, and histoplasmosis are compared.Case history, imaging and laboratory tests have important diagnostic impact...
October 18, 2017: Pneumologie
https://www.readbyqxmd.com/read/29044064/utility-of-angiotensin-converting-enzyme-activity-in-aqueous-humor-in-the-diagnosis-of-ocular-sarcoidosis
#12
Violeta Mihailovic-Vucinic, Ljubica Popevic, Spasoje Popevic, Mihailo Stjepanovic, Andjelka Aleksic, Anka Stanojevic-Paovic
PURPOSE: Many studies include elevated activity of angiotensin-converting enzyme (ACE) in serum in sarcoidosis and in ocular sarcoidosis as well, but there are only a few analyzing ACE activities in aqueous humor. The aim of this study is to illuminate the diagnostic value of ACE in aqueous humor in patients with ocular sarcoidosis. METHODS: We analyzed twenty patients with ocular sarcoidosis and 18 patients with nonocular involvement. All patients have biopsy-positive sarcoidosis of the lungs and/or mediastinal lymph nodes...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043557/a-joint-procedural-position-statement-on-imaging-in-cardiac-sarcoidosis-from-the-cardiovascular-and-inflammation-infection-committees-of-the-european-association-of-nuclear-medicine-the-european-association-of-cardiovascular-imaging-and-the-american-society
#13
Riemer H J A Slart, Andor W J M Glaudemans, Patrizio Lancellotti, Fabien Hyafil, Ron Blankstein, Ronald G Schwartz, Wael A Jaber, Raymond Russell, Alessia Gimelli, François Rouzet, Marcus Hacker, Olivier Gheysens, Sven Plein, Edward J Miller, Sharmila Dorbala, Erwan Donal
No abstract text is available yet for this article.
October 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29038949/sleep-disorders-and-health-related-quality-of-life-in-patients-with-interstitial-lung-disease
#14
Maria Mavroudi, Despoina Papakosta, Theodore Kontakiotis, Kaliopi Domvri, George Kalamaras, Vasiliki Zarogoulidou, Paul Zarogoulidis, Paschalina Latka, Haidong Huang, Wolfgang Hohenforst-Schmidt, Konstantinos Zarogoulidis
BACKGROUND: Interstitial lung diseases (ILD) are chronic and restrictive lung diseases with poor survival and quality of life. The aim of this study was to investigate the frequency of sleep disorders in idiopathic pulmonary fibrosis (IPF) and sarcoidosis and to assess patients' quality of life in relation to these disorders. METHODS: Forty patients, 19 with IPF, and 21 with sarcoidosis stage II/III were included. They were compared with 15 healthy subjects. All patients performed all-night polysomnography (PSG) and completed the Epworth, Berlin, and Stop-Bang questionnaires...
October 16, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29038921/muscular-sarcoidosis-involving-the-chest-and-abdominal-walls-case-report-with-mr-imaging
#15
Seunghyun Lee, In Sook Lee, Jeongha Mok, You Seon Song, Kyung-Un Choi
Sarcoidosis is an inflammatory disorder that is characterized by the presence of noncaseating granulomas in tissues, involving many organs and tissues. Extra-pulmonary, especially muscular sarcoidosis is a rare condition. The most common location of the muscular sarcoidosis is known to be the proximal muscles of the extremities; however, there have been no cases of diffuse involvement of the chest and abdominal wall muscles. Here, we report a rare muscular sarcoidosis with infiltrative pattern in the chest and abdominal wall muscles and describe the MR imaging findings that were mistaken as lymphoma at initial diagnosis...
October 16, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29037464/-ocular-sarcoidosis-what-the-internist-should-know
#16
P Sève, L Kodjikian, Y Jamilloux
Sarcoidosis is one of the leading causes of inflammatory eye disease. Any part of the eye and its adnexal tissues can be involved. Uveitis and optic neuropathy are the main manifestations, which the internists face. This review reports the state of knowledge for these two ocular involvements and proposes an assessment-algorithm for sarcoidosis in patients with suspected sarcoid uveitis. Two groups of patients with sarcoid uveitis can be distinguished: one young and multiethnic group in which ophthalmological findings are various and another group of elderly Caucasian women with mostly chronic posterior uveitis...
October 13, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29036970/-update-on-the-diagnosis-and-management-of-cardiac-sarcoidosis
#17
Q Zhu, X Q Hu, S H Zhou
No abstract text is available yet for this article.
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29035991/myocardial-perfusion-spect-and-cardiac-mr-correlative-imaging
#18
Ashley E Prosper, Patrick M Colletti
An institutional review board-approved retrospective review of 55 patients who received cardiac MRI within 1 year of myocardial SPECT was performed. Forty-nine demonstrated myocardial infarction by MRI. MRI and SPECT agreed in all but 1 case, where SPECT preceded MRI by 97 days. Three cases are presented here: 2 demonstrating congruent MRI and SPECT changes in a vascular distribution status post infarction and a third with a nonvascular pattern of abnormalities related to left ventricular aneurysm in cardiac sarcoidosis...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29033821/certolizumab-pegol-induced-folliculitis-like-lichenoid-sarcoidosis-in-a-patient-with-rheumatoid-arthritis
#19
Hiroyuki Sakai, Wakana Nomura, Motoshi Sugawara
Anti-tumor necrosis factor α (TNF-α) biologic agents are used for treating refractory sarcoidosis. However, sarcoidosis-like epithelioid cell granulomas may develop during anti-TNF-α treatment. A 63-year-old man suffering from rheumatoid arthritis was treated with oral methotrexate and methylprednisolone for 4 years. He subsequently started biweekly subcutaneous injections of certolizumab pegol. Three months later, light red follicular papules developed on his chest and they spread over the trunk and bilateral upper arms...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29033431/diagnostic-challenge-in-pancreatic-sarcoidosis-using-endoscopic-ultrasonography
#20
Nobuaki Azemoto, Teru Kumagi, Mitsuhito Koizumi, Taira Kuroda, Hirofumi Yamanishi, Yoshinori Ohno, Yoshiki Imamura, Eiji Takeshita, Yoshiko Soga, Yoshiou Ikeda, Morikazu Onji, Yoichi Hiasa
We herein report a 55-year-old woman who presented with erythema and bilateral hilar lymphadenopathy 4 months prior to the detection of pancreatic lesions on an ultrasound. A skin biopsy showed evidence of sarcoidosis. The largest lesion in the tail of the pancreas was hypoechoic on endoscopic ultrasonography (EUS). The lesion was initially iso-enhanced on contrast enhanced-EUS (CE-EUS) but subsequently became hypoenhanced. The lesion revealed heterogeneous components of both soft and hard tissue on EUS elastography...
October 16, 2017: Internal Medicine
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