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Sarcoidosis

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https://www.readbyqxmd.com/read/29924748/granulomatous-tumoral-melanosis-associated-with-pembrolizumab-therapy-a-mimicker-of-disease-progression-in-metastatic-melanoma
#1
Randi Woodbeck, Andrei I Metelitsa, Karen A Naert
Immune checkpoint inhibitor therapy has revolutionized the treatment of advanced melanoma, with these agents significantly improving survival for patients with metastatic disease. With the increasing use of these agents, the number of adverse reactions secondary to their use has also increased. Sarcoidosis and sarcoid-like reactions are one such immune checkpoint inhibitor-related adverse event. We report a case of sarcoid-like granulomatous tumoral melanosis in a patient on the programmed cell death-1 (PD-1) receptor inhibitor pembrolizumab for metastatic melanoma...
July 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29924418/glucocorticoid-exposure-and-fracture-risk-in-a-cohort-of-us-patients-with-selected-conditions
#2
A Balasubramanian, S W Wade, R A Adler, K Saag, N Pannacciulli, J R Curtis
PURPOSE: We evaluated systemic glucocorticoid exposure and fracture among patients with newly-diagnosed inflammatory and immune-modulated conditions. METHODS: Using administrative data, inception cohorts of RA, asthma/COPD, IBD, MS, lupus, and sarcoidosis patients age 18-64 years with benefits coverage ≥12 months before diagnosis (1/1/2005-12/31/2012) were followed to clinical fracture, cancer diagnosis, or 12/31/2012. Glucocorticoid users were new to therapy...
June 20, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29922952/sarcoidosis-of-the-central-nervous-system-clinical-features-imaging-and-csf-results
#3
Desmond P Kidd
OBJECTIVE: Neurological complications of systemic sarcoidosis are uncommon and the natural history and optimal treatments under-researched. With the advent of modern biological therapies, it is important to define the clinical characteristics and immunopathology of the disease. METHODS: Patients referred to and treated within the Centre for Neurosarcoidosis over a 15 year period who had biopsy-proven "highly probable" disease of the central nervous system were studied prospectively...
June 19, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29914898/identification-of-left-ventricular-chamber-like-aneurysm-related-to-cardiac-sarcoidosis
#4
Mikio Shiba, Daisuke Kitano, Satoshi Kunimoto, Atsushi Hirayama
No abstract text is available yet for this article.
June 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29908181/ppar-gamma-pathways-attenuate-pulmonary-granuloma-formation-in-a-carbon-nanotube-induced-murine-model-of-sarcoidosis
#5
Matthew McPeek, Anagha Malur, Debra A Tokarz, Gina Murray, Barbara P Barna, Mary Jane Thomassen
Peroxisome proliferator activated receptor gamma (PPARγ), a ligand activated nuclear transcription factor, is constitutively expressed in alveolar macrophages of healthy individuals. PPARγ deficiencies have been noted in several lung diseases including the alveolar macrophages of pulmonary sarcoidosis patients. We have previously described a murine model of multiwall carbon nanotube (MWCNT) induced pulmonary granulomatous inflammation which bears striking similarities to pulmonary sarcoidosis, including the deficiency of alveolar macrophage PPARγ...
June 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29904803/atypical-cutaneous-presentations-of-sarcoidosis-two-case-reports-and-review-of-the-literature
#6
REVIEW
David L Leverenz, Christopher Henderson, Ankoor Shah
PURPOSE OF REVIEW: The goal of this review is to provide the reader with an updated summary of the cutaneous manifestations of systemic sarcoidosis, with a particular emphasis on the predilection of sarcoidosis for scars, tattoos, and other areas of traumatized skin. RECENT FINDINGS: While the mechanism underlying the propensity for traumatized skin to develop sarcoidosis lesions remains unclear, several theories have been proposed including the idea that cutaneous sarcoidosis represents an exuberant, antigen-driven foreign-body response, as well as the theory that traumatized skin represents an immunocompromised district with altered local immune trafficking and neural signaling...
June 14, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29904593/case-report-pulmonary-and-liver-sarcoidosis-suspected-of-metastasis
#7
Behnam Jafari, Gholamabas Sabz, Elahe Masnavi, Roghaye Panahi, Saeid Jokar, Amrollah Roozbehi, Sajad Hasanzadeh
Introduction : Sarcoidosis is a granulomatous disease with unknown cause that can vary from an asymptomatic condition. Almost half of the patients with sarcoidosis have no symptoms. In this article, we describe a sarcoidosis patient with lung and liver engagement; it may be confused with metastasis. Case report : A 39-year-old man, with known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment. The patient smoked for 10 years (3 pack/year)...
2018: F1000Research
https://www.readbyqxmd.com/read/29898781/thoracic-and-cutaneous-sarcoid-like-reaction-associated-with-anti-pd-1-therapy-longitudinal-monitoring-of-pd-1-and-pd-l1-expression-after-stopping-treatment
#8
Léa Paolini, Caroline Poli, Simon Blanchard, Thierry Urban, Anne Croué, Marie-Christine Rousselet, Sarah Le Roux, Nathalie Labarrière, Pascale Jeannin, José Hureaux
BACKGROUND: Immune checkpoint inhibitors (ICI) target T cell inhibitory pathways that are responsible for cancer tolerance by down-modulating immune functions. ICI have revolutionized patients care with lung cancer. Nevertheless, restoring endogenous antitumor T-cell responses can induce immune related adverse events, such as sarcoidosis. CASE PRESENTATION: We report here the first case of a thoracic and cutaneous sarcoid-like reaction in a patient with a relapsing unresectable non-small cell lung cancer (NSCLC) treated with nivolumab, an anti-PD-1 mAb...
June 13, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29892684/vaginal-sarcoidosis-without-other-organ-involvement-in-a-patient-with-a-history-of-endometrial-cancer-a-case-report
#9
A T Knisely, M R Girton, H C Hintz, S C Modesitt
•Patient with history of endometrial cancer presented with vaginal discharge.•Biopsy showed non-necrotizing granulomas, potentially sarcoidosis.•She responded to steroids with symptom resolution.
February 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29892670/drug-induced-sarcoidosis-in-a-patient-treated-with-an-interleukin-1-receptor-antagonist-for-hidradenitis-suppurativa
#10
Blake E Friedman, Joseph C English
No abstract text is available yet for this article.
July 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29892550/the-fear-of-lymphadenopathy-a-cautionary-case-of-sarcoidosis-masquerading-as-recurrent-diffuse-large-b-cell-lymphoma-dlbcl
#11
Peter D Whooley, Russell K Dorer, David M Aboulafia
We describe the cautionary case of a patient with advanced-stage large B-cell lymphoma (DLBCL). After combination chemotherapy, CT-PET revealed a persistent focus of likely DLBCL for which he received radiotherapy. Follow-up CT-PET showed diffuse hypermetabolic adenopathy and recurrent DLBCL was presumed. As part of clinical trial assessment, multiple biopsies showed non-caseating lymphadenitis consistent with sarcoidosis. No treatment for asymptomatic sarcoidosis was required and 18 months later he remains cancer-free...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29891069/immune-mediated-ataxias
#12
Bastien Joubert, Kevin Rostásy, Jérôme Honnorat
Immune-mediated cerebellar ataxia (CA) comprises a group of rare diseases that are still incompletely described, and are probably underdiagnosed. Both acute and progressive progressions are possible. Different syndromes have been identified, including CA associated with anti-GAD antibodies, the cerebellar type of Hashimoto encephalopathy, primary autoimmune CA, gluten ataxia, opsoclonus-myoclonus syndrome, and paraneoplastic cerebellar degenerations. Most of these syndromes are associated with autoantibodies targeting neuronal antigens...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29889115/the-fatigue-assessment-scale-quality-and-availability-in-sarcoidosis-and-other-diseases
#13
Celine Hendriks, Marjolein Drent, Marjon Elfferich, Jolanda De Vries
PURPOSE OF REVIEW: Fatigue is a problem experienced by many patients suffering from chronic diseases, including sarcoidosis patients. It has a substantial influence on patients' quality of life (QoL). It is, therefore, important to properly assess fatigue with a valid and reliable measure. The Fatigue Assessment Scale (FAS) is the only validated self-reporting instrument classifying fatigue in sarcoidosis. The aim of this review was to examine the psychometric properties of the FAS and the diseases and languages in which it has been used...
June 7, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29889033/disseminated-multi-system-sarcoidosis-mimicking-metastases-on-18-f-fdg-pet-ct
#14
William Makis, Mark Palayew, Christopher Rush, Stephan Probst
A 60-year-old female with no significant medical history presented with hematuria. A computed tomography (CT) scan revealed extensive lymphadenopathy with hypodensities in the liver and spleen, and she was referred for an 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/CT (PET/CT) study to assess for malignancy of unknown primary. PET/CT revealed extensive 18 F-FDG avid lymphadenopathy as well as innumerable intensely 18 F-FDG avid lung, liver and splenic nodules, highly concerning for malignancy...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29884710/concomitant-sarcoidosis-and-papillary-thyroid-cancer-with-severe-hypercalcaemia-as-the-main-symptom
#15
Mikael Groth Riis, Kasper Svendsen Juhl, Jens Meldgaard Bruun
A 65-year-old Caucasian man was admitted to our hospital due to incidental finding of plasma ionised calcium=1.83 mmol/L. During the previous months, he had felt more tired and had experienced an unintended weight loss of 6-8 kg. A CT scan revealed an inhomogeneous thyroid gland and enlarged lymph nodes along the cervical vessels and in the mediastinum. The patient underwent total thyroidectomy and, at the same time, two lymph nodes were removed. Histological examination of the thyroid gland revealed papillary thyroid carcinoma (PTC), T1aN0M0, and histological examination of the lymph nodes showed non-caseating granulomatous inflammation...
June 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29883224/treatment-of-sarcoidosis-grading-the-evidence
#16
W Ennis James, Robert Baughman
Treatment of sarcoidosis recommendations are often based on clinical experience and expert opinion. However, there are an increasing number of studies which are providing evidence to support decisions regarding treatment. Areas covered: Several studies have identified factors associated with increased risk for organ failure or death ('danger'). There have been several studies focused on the role of treatment to improve quality of life for the patient. Sarcoidosis treatment often follows a progression, based on response...
June 18, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29881952/-what-rheumatologists-can-learn-from-ophthalmologists
#17
REVIEW
M D Becker, R Max, A Dimitriou, T Saurenmann, H-M Lorenz, A Jansen, S Lortz, J Grulich-Henn, M Weber
Intraocular inflammation with the imprecise and broad umbrella term "uveitis" is a diagnostic and therapeutic challenge in ophthalmology. Uveitis is one of the most common causes of blindness worldwide and due to the associated costs is comparable to diabetic retinopathy. Patients can be affected by uveitis at any age. Any part of the eye may be affected. The symptoms range from complete absence of symptoms, through all types of vision deterioration up to a red and even very painful eye. Uveitis can be strictly unilateral (also alternating from the left to the right eye) or bilateral with a relapsing or chronic course...
June 7, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29880538/restrictive-lung-defects-parenchymal-chest-wall-and-neuromuscular
#18
Anne-Marie Shanks, Sujal R Desai, Alexandra Rice, Stephen R Thomas, Michael I Polkey, Peter M George
Sarcoidosis is a multisystem condition which may affect a number of organs and, within the cardiopulmonary system, most commonly manifests as parenchymal, airway-centred, nodal, vascular or cardiac disease. Pleural involvement is rare, but well described, and often presents as pleural effusions or pleural thickening. Here, we present the first case of active sarcoidosis manifesting as bilateral pleural calcification. We highlight the importance of a nuanced understanding of pulmonary physiology when dissecting coexistent extrathoracic and intrathoracic pulmonary restriction...
June 7, 2018: Thorax
https://www.readbyqxmd.com/read/29876123/bi-atrial-fibrosis-detected-using-three-dimensional-late-gadolinium-enhancement-magnetic-resonance-imaging-in-a-patient-with-cardiac-sarcoidosis
#19
Stewart Spence, Elena Pena, Rebecca E Thornhill, Pablo B Nery, David H Birnie
Presented is the case of a 62-year old male with a history of sarcoidosis and sinus node dysfunction, who underwent late gadolinium enhancement magnetic resonance imaging, which demonstrated left ventricular hyperenhancement and bi-atrial fibrosis.
May 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29872238/tuberculosis-of-the-oral-cavity-misdiagnosed-as-precancerous-lesion
#20
Vanja Vučičević Boras, Dragana Gabrić, Ljiljana Smiljanić Tomičević, Sven Seiwerth, Krešimir Gršić, Božena Šarčević, Božana Lončar Brzak, Emilija Marunica, Ana Glavina
Introduction: The aim of this case report was to discuss an extremely rare oral lesion as a result of primary pulmonary tuberculosis. Case report: In this case report, the patient with refractory painless ulceration at ventral surface of the tongue was described. Detailed medical history was taken followed by clinical examination of the oral mucosa and palpation of regional lymph nodes. Clinical examination revealed ulceration on the patient's ventro-lateral surface of the tongue, approximately two centimeters in diameter...
December 2017: Acta Stomatologica Croatica
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