keyword
MENU ▼
Read by QxMD icon Read
search

Neuropathologic

keyword
https://www.readbyqxmd.com/read/29922152/naringin-dihydrochalcone-ameliorates-cognitive-deficits-and-neuropathology-in-app-ps1-transgenic-mice
#1
Wenjuan Yang, Keyan Zhou, Yue Zhou, Yuqian An, Tingting Hu, Jing Lu, Shichao Huang, Gang Pei
Alzheimer's disease (AD) is a multi-factorial neurodegenerative disorder with abnormal accumulation of amyloid-β (Aβ) plaques, neuroinflammation and impaired neurogenesis. Mounting evidences suggest that single-target drugs have limited effects on clinical treatment and alternative or multiple targets are required. In recent decades, natural compounds and their derivatives have gained increasing attention in AD drug discovery due to their inherently enormous chemical and structural diversity. In this study, we demonstrated that naringin dihydrochalcone (NDC), a widely used dietary sweetener with strong antioxidant activity, improved the cognitive function of transgenic AD mice...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29922147/deciphering-the-astrocyte-reaction-in-alzheimer-s-disease
#2
REVIEW
Beatriz G Perez-Nievas, Alberto Serrano-Pozo
Reactive astrocytes were identified as a component of senile amyloid plaques in the cortex of Alzheimer's disease (AD) patients several decades ago. However, their role in AD pathophysiology has remained elusive ever since, in part owing to the extrapolation of the literature from primary astrocyte cultures and acute brain injury models to a chronic neurodegenerative scenario. Recent accumulating evidence supports the idea that reactive astrocytes in AD acquire neurotoxic properties, likely due to both a gain of toxic function and a loss of their neurotrophic effects...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29921875/a-faroese-founder-variant-in-tbcd-causes-early-onset-progressive-encephalopathy-with-a-homogenous-clinical-course
#3
Sabine Grønborg, Lotte Risom, Jakob Ek, Karen Bonde Larsen, David Scheie, Yanko Petkov, Vibeke André Larsen, Morten Dunø, Fróði Joensen, Elsebet Østergaard
An intact and dynamic microtubule cytoskeleton is crucial for the development, differentiation, and maintenance of the mammalian cortex. Variants in a host of structural microtubulin-associated proteins have been identified to cause a wide spectrum of malformations of cortical development and alterations of microtubule dynamics have been recognized to cause or contribute to progressive neurodegenerative disorders. TBCD is one of the five tubulin-specific chaperones and is required for reversible assembly of the α-/β-tubulin heterodimer...
June 19, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29921762/tb-ii-i-a-fraction-isolated-from-tityus-bahiensis-scorpion-venom-alters-cytokines-level-and-induces-seizures-when-intrahippocampally-injected-in-rats
#4
Emidio Beraldo Neto, Douglas O C Mariano, Lucas A Freitas, Ana L C Dorce, Adriana N Martins, Daniel C Pimenta, Fernanda C V Portaro, Daniela Cajado-Carvalho, Valquiria A C Dorce, Ana L A Nencioni
Scorpion venoms are composed of several substances with different pharmacological activities. Neurotoxins exert their effects by targeting ion channels resulting in toxic effects to mammals, insects and crustaceans. Tb II-I, a fraction isolated from Tityus bahiensis scorpion venom, was investigated for its ability to induce neurological and immune-inflammatory effects. Two putative β-sodium channel toxins were identified in this fraction, Tb2 II and Tb 4, the latter having been completely sequenced by mass spectrometry...
June 19, 2018: Toxins
https://www.readbyqxmd.com/read/29920583/5-aminolevulinic-acid-induced-fluorescence-in-focal-cortical-dysplasia-report-of-3-cases
#5
David W Roberts, Jaime J Bravo, Jonathan D Olson, William F Hickey, Brent T Harris, Lananh N Nguyen, Jennifer Hong, Linton T Evans, Xiaoyao Fan, Dennis Wirth, Brian C Wilson, Keith D Paulsen
BACKGROUND: Three patients enrolled in a clinical trial of 5-aminolevulinic-acid (5-ALA)-induced fluorescence-guidance, which has been demonstrated to facilitate intracranial tumor resection, were found on neuropathological examination to have focal cortical dysplasia (FCD). OBJECTIVE: To evaluate in this case series visible fluorescence and quantitative levels of protoporphyrin IX (PpIX) during surgery and correlate these findings with preoperative magnetic resonance imaging (MRI) and histopathology...
June 16, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29916037/non-alzheimer-s-contributions-to-dementia-and-cognitive-resilience-in-the-90-study
#6
John L Robinson, Maria M Corrada, Gabor G Kovacs, Myrna Dominique, Carrie Caswell, Sharon X Xie, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowski
The diagnosis of Alzheimer's disease (AD) in the oldest-old is complicated by the increasing prevalence of age-related neurofibrillary tangles, plaques and non-AD pathologies such as cerebrovascular disease (CVD), hippocampal sclerosis (HS), aging-related tau astrogliopathy (ARTAG), as well as TDP-43 and Lewy pathology. The contribution of these non-AD pathologies to dementia and cognitive resilience is unclear. We assessed the level of AD neuropathologic change (ADNPC) and non-AD pathology in 185 participants enrolled in The 90+ Study with available cognitive assessments and brain tissue...
June 18, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29915582/imbalance-of-circulating-t-h-17-and-regulatory-t-cells-in-alzheimer-s-disease-a-case-control-study
#7
Timo Jan Oberstein, Lava Taha, Philipp Spitzer, Janina Hellstern, Martin Herrmann, Johannes Kornhuber, Juan Manuel Maler
The neuropathological hallmarks of Alzheimer's disease (AD), i.e., neuritic plaques and neurofibrillary tangles, consist of beta amyloid peptides (Aβ) and hyperphosphorylated Tau. These are accompanied by reactive microglia and astrocytes in the vicinity of the neuritic plaques and by changes to the peripheral immune system, e.g., an increase of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in the peripheral blood. To address a potential involvement of peripheral T helper cell (Th ) subsets in AD, we conducted a case control study with 54 individuals with AD dementia ( n  = 14), with mild cognitive impairment (MCI) due to AD (MCIAD , n  = 14), with MCI unlikely due to AD (MCIother , n  = 13), and controls without cognitive impairment (controls, n  = 13)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29914543/hepatitis-b-core-vlp-based-mis-disordered-tau-vaccine-elicits-strong-immune-response-and-alleviates-cognitive-deficits-and-neuropathology-progression-in-tau-p301s-mouse-model-of-alzheimer-s-disease-and-frontotemporal-dementia
#8
Mei Ji, Xi-Xiu Xie, Dong-Qun Liu, Xiao-Lin Yu, Yue Zhang, Ling-Xiao Zhang, Shao-Wei Wang, Ya-Ru Huang, Rui-Tian Liu
BACKGROUND: Truncated mis-disordered tau protein plays an important role in the pathogenesis of Alzheimer's disease (AD) and frontotemporal dementia (FTD). Tau294-305 , an epitope in the truncated tau, is essential for pathological tau-tau interaction and aggregation. A tau294-305 -targeted approach may have beneficial effects in the treatment of AD and FTD. METHODS: In this study, we genetically fused tau294-305 epitope to the hepatitis B virus core protein (HBc) major immunodominant region (MIR) (with the resultant protein termed T294-HBc), and we subcutaneously immunized a Tau...
June 19, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29914034/genotyping-of-the-alzheimer-s-disease-genome-wide-association-study-index-single-nucleotide-polymorphisms-in-the-brains-for-dementia-research-cohort
#9
Keeley J Brookes, George McConnell, Kirsty Williams, Sultan Chaudhury, Gaganjit Madhan, Tulsi Patel, Christopher Turley, Tamar Guetta-Baranes, Jose Bras, Rita Guerreiro, John Hardy, Paul T Francis, Kevin Morgan
The Brains for Dementia Research project is a recently established longitudinal cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer's disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOEɛ4 allele was identified (p = 3.99×10-12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al...
June 8, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29914033/a-study-of-amyloid-%C3%AE-and-phosphotau-in-plaques-and-neurons-in-the-hippocampus-of-alzheimer-s-disease-patients
#10
Diana Furcila, Javier DeFelipe, Lidia Alonso-Nanclares
The main pathological hallmarks in Alzheimer's disease (AD) are the presence of extracellular amyloid plaques, primarily consisting of amyloid-β (Aβ) peptide, and the accumulation of paired helical filaments of hyperphosphorylated tau protein (PHF - Tau) within neurons. Since CA1 is one of the most affected regions in AD, mainly at early stages, we have performed a detailed analysis of the CA1 region from 11 AD patients (demented and clinically homogeneous; Braak stages IV-VI) to better understand the possible relationship between the presence and distribution of different neurochemical types of Aβ plaques and PHF - Tau immunoreactive  (- ir)  neurons...
June 8, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29912767/genetic-alterations-of-epidermal-growth-factor-receptor-in-glioblastoma-the-usefulness-of-immunohistochemistry
#11
Minju Lee, So Young Kang, Yeon-Lim Suh
Epidermal growth factor receptor (EGFR) amplification is one of the common alterations in IDH-wildtype glioblastoma. It is frequently associated with EGFRvIII mutation. To evaluate the correlation between EGFR overexpression, gene amplification, and EGFRvIII mutation, we performed immunohistochemical (IHC) analysis, fluorescence in situ hybridization by Vysis LSI EGFR/CEP7 dual color probe, and polymerase chain reaction studies in 76 patients diagnosed with glioblastomas (67 IDH-wildtype and 9 IDH-mutant). EGFR expression was scored ranging from 0 to 3+...
June 15, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29911915/targeting-glucose-dependent-insulinotropic-polypeptide-receptor-for-neurodegenerative-disorders
#12
Mahip K Verma, Rajan Goel, Nandakumar Krishnadas, Kumar V S Nemmani
Incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon like peptide (GLP-1) exert pleiotropic effects on the endocrine pancreas and nervous system. Expression of GIP and GIP receptor (GIPR) in neurons, their roles in neurogenesis, synaptic plasticity, neurotransmission and neuromodulation, uniquely positions GIPR for therapeutic applications in neurodegenerative disorders. GIP analogues acting as GIPR agonists attenuate neurobehavioral and neuropathological sequelae of neurodegenerative disorders in preclinical models, e...
June 18, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29910805/ip-10-promotes-blood-brain-barrier-damage-by-inducing-tumor-necrosis-factor-alpha-production-in-japanese-encephalitis
#13
Ke Wang, Haili Wang, Wenjuan Lou, Longhuan Ma, Yunchuan Li, Nan Zhang, Chong Wang, Fang Li, Muhammad Awais, Shengbo Cao, Ruiping She, Zhen F Fu, Min Cui
Japanese encephalitis is a neuropathological disorder caused by Japanese encephalitis virus (JEV), which is characterized by severe pathological neuroinflammation and damage to the blood-brain barrier (BBB). Inflammatory cytokines/chemokines can regulate the expression of tight junction (TJ) proteins and are believed to be a leading cause of BBB disruption, but the specific mechanisms remain unclear. IP-10 is the most abundant chemokine produced in the early stage of JEV infection, but its role in BBB disruption is unknown...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29910801/lifelong-impacts-of-moderate-prenatal-alcohol-exposure-on-neuroimmune-function
#14
REVIEW
Shahani Noor, Erin D Milligan
In utero alcohol exposure is emerging as a major risk factor for lifelong aberrant neuroimmune function. Fetal alcohol spectrum disorder encompasses a range of behavioral and physiological sequelae that may occur throughout life and includes cognitive developmental disabilities as well as disease susceptibility related to aberrant immune and neuroimmune actions. Emerging data from clinical studies and findings from animal models support that very low to moderate levels of fetal alcohol exposure may reprogram the developing central nervous system leading to altered neuroimmune and neuroglial signaling during adulthood...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29909365/histogram-profiling-of-postcontrast-t1-weighted-mri-gives-valuable-insights-into-tumor-biology-and-enables-prediction-of-growth-kinetics-and-prognosis-in-meningiomas
#15
Georg Alexander Gihr, Diana Horvath-Rizea, Patricia Kohlhof-Meinecke, Oliver Ganslandt, Hans Henkes, Cindy Richter, Karl-Titus Hoffmann, Alexey Surov, Stefan Schob
BACKGROUND: Meningiomas are the most frequently diagnosed intracranial masses, oftentimes requiring surgery. Especially procedure-related morbidity can be substantial, particularly in elderly patients. Hence, reliable imaging modalities enabling pretherapeutic prediction of tumor grade, growth kinetic, realistic prognosis, and-as a consequence-necessity of surgery are of great value. In this context, a promising diagnostic approach is advanced analysis of magnetic resonance imaging data...
June 14, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29908416/postmortem-brain-mri-is-related-to-cognitive-decline-independent-of-cerebral-vessel-disease-in-older-adults
#16
Robert J Dawe, Lei Yu, Julie A Schneider, Konstantinos Arfanakis, David A Bennett, Patricia A Boyle
The purpose of this study was to determine whether metrics of brain tissue integrity derived from postmortem magnetic resonance imaging (MRI) are associated with late-life cognitive decline, independent of cerebral vessel disease. Using data from 554 older adults, we used voxelwise regression to identify regions where the postmortem MRI transverse relaxation rate constant R2 was associated with the rate of decline in global cognition. We then used linear mixed models to investigate the association between a composite R2 measure and cognitive decline, controlling for neuropathology including 3 indices of vessel disease: atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy...
May 23, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29908079/targeted-brain-proteomics-uncover-multiple-pathways-to-alzheimer-s-dementia
#17
Lei Yu, Vladislav A Petyuk, Chris Gaiteri, Sara Mostafavi, Tracy Young-Pearse, Raj C Shah, Aron S Buchman, Julie A Schneider, Paul D Piehowski, Ryan L Sontag, Thomas L Fillmore, Tujin Shi, Richard D Smith, Philip L De Jager, David A Bennett
OBJECTIVE: Previous gene expression analysis identified a network of co-expressed genes that is associated with β-amyloid neuropathology and cognitive decline in older adults. The current work targeted influential genes in this network with quantitative proteomics to identify potential novel therapeutic targets. METHODS: Data came from 834 community-based older persons who were followed annually, died and underwent brain autopsy. Uniform structured postmortem evaluations assessed the burden of β-amyloid and other common age-related neuropathologies...
June 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29908063/oligonucleotide-therapy-mitigates-disease-in-spinocerebellar-ataxia-type-3-mice
#18
Hayley S McLoughlin, Lauren R Moore, Ravi Chopra, Robert Komlo, Megan McKenzie, Kate G Blumenstein, Hien Zhao, Holly B Kordasiewicz, Vikram G Shakkottai, Henry L Paulson
OBJECTIVE: Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, is the most common dominantly inherited ataxia. Despite advances in understanding this CAG repeat/polyglutamine expansion disease, there are still no therapies to alter its progressive fatal course. Here we investigate whether an antisense oligonucleotide (ASO) targeting the SCA3 disease gene, ATXN3, can prevent molecular, neuropathological, electrophysiological and behavioral features of the disease in a mouse model of SCA3...
June 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29906478/does-nicotine-impact-tramadol-abuse-insights-from-neurochemical-and-neurobehavioral-changes-in-mice
#19
Shimaa M Azmy, Mai A Abd El Fattah, Sahar S Abd El-Rahman, Somia A Nada, Omar M E Abdel Salam, Mohammed F El-Yamany, Noha N Nassar
Nicotine and tramadol concomitant drug dependence pose increasing social, economic as well as public threats. Accordingly, the present study investigated neurochemical, neurobehavioral and neuropathological changes in the brain subsequent to the interaction of nicotine and tramadol. To this end, tramadol (20 mg/kg, i.p) and nicotine (0.25 mg/kg, i.p) were administrated to male albino mice once daily for 30 days. Consequent to microglial activation, nicotine exacerbated oxidative/nitrosative stress induced by tramadol as manifest by the step-up in thiobarbituric acid reactive substances and nitric oxide subsequent to the enhanced levels of neuronal and inducible nitric oxide synthases; paralleled by decreased non-protein sulfhydryls...
June 12, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29906409/designing-a-new-multifunctional-peptide-for-metal-chelation-and-a%C3%AE-inhibition
#20
Amir Shamloo, Mohsen Asadbegi, Vahid Khandan, Amirhossein Amanzadi
According to the Amyloid hypothesis, as the foremost scientific explanation for Alzheimer Disease (AD), the neuropathology of AD is related to toxic fragments of amyloid beta (Aβ) protein. Based on this hypothesis, an attractive therapeutic approach was demonstrated to identify multifunctional peptides able to modulate Aβ pathologies as the source of AD. On this premise, a bifunctional polypeptide based on the iAβ5p lead compound, was designed to inhibit Aβ aggregation and free metal ions. Herein, the efficacy of this novel drug in Zn2+ and Cd2+ ion chelation was examined through an integrated technique comprising combined Docking, QM, and MD simulations...
June 12, 2018: Archives of Biochemistry and Biophysics
keyword
keyword
29913
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"