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JOURNAL ARTICLE
Qingyi Duan, Xing Liu, Ailing Zhang
The research was conducted to investigate the improvement of agitated behaviors, cognitive functions, and negative emotions among patients with senile dementia and the burden of caregivers after simulated presence therapy (SPT) intervention. 85 patients with senile dementia were included as the research subjects and divided into control group (40 cases performed with routine nursing) and observation group (45 cases undergoing routine nursing combined with SPT) via a random number table method. Cohen-Mansfield agitation inventory (CAMI) and protective constraint were used to assess the improvement of agitated behaviors among patients...
April 22, 2024: International Journal of Neuroscience
#22
JOURNAL ARTICLE
Maram Ali M Alwadi, Sarah R Baker, Janine Owens
BACKGROUND: Children with disabilities generally face poorer oral health outcomes compared with their non-disabled peers due to a range of factors including inadequate oral hygiene, infrequent dental visits and systemic barriers in accessing care. AIM: This ethnographic study explored the perspectives of caregivers and professionals to identify the ways that children with disabilities are included in oral health. DESIGN: A purposive sample of 10 caregivers, all mothers with disabled children aged 9-15 years, five healthcare providers and five educators in Saudi Arabia, participated...
April 22, 2024: International Journal of Paediatric Dentistry
#23
Amy C Moreno, Erin E Watson, Laia Humbert-Vidan, Douglas E Peterson, Lisanne V van Dijk, Teresa Guerrero Urbano, Lisa Van den Bosch, Andrew J Hope, Matthew S Katz, Frank J P Hoebers, Ruth A Aponte Wesson, James E Bates, Paolo Bossi, Adeyinka F Dayo, Mélanie Doré, Eduardo Rodrigues Fregnani, Thomas J Galloway, Daphna Y Gelblum, Issa A Hanna, Christina E Henson, Sudarat Kiat-Amnuay, Anke Korfage, Nancy Y Lee, Carol M Lewis, Charlotte Duch Lynggaard, Antti A Mäkitie, Marco Magalhaes, Yvonne M Mowery, Carles Muñoz-Montplet, Jeffrey N Myers, Ester Orlandi, Jaymit Patel, Jillian M Rigert, Deborah Saunders, Jonathan D Schoenfeld, Ugur Selek, Efsun Somay, Vinita Takiar, Juliette Thariat, Gerda M Verduijn, Alessandro Villa, Nick West, Max J H Witjes, Alex Won, Mark E Wong, Christopher M K L Yao, Simon W Young, Kamal Al-Eryani, Carly E A Barbon, Doke J M Buurman, François J Dieleman, Theresa M Hofstede, Abdul Ahad Khan, Adegbenga O Otun, John C Robinson, Lauren Hum, Jorgen Johansen, Rajesh Lalla, Alexander Lin, Vinod Patel, Richard J Shaw, Mark S Chambers, Daniel Ma, Mabi Singh, Noam Yarom, Abdallah Sherif Radwan Mohamed, Katherine A Hutcheson, Stephen Y Lai, Clifton David Fuller
PURPOSE: Osteoradionecrosis of the jaw (ORNJ) is a severe iatrogenic disease characterized by bone death after radiation therapy (RT) to the head and neck. With over 9 published definitions and at least 16 diagnostic/staging systems, the true incidence and severity of ORNJ are obscured by lack of a standard for disease definition and severity assessment, leading to inaccurate estimation of incidence, reporting ambiguity, and likely under-diagnosis worldwide. This study aimed to achieve consensus on an explicit definition and phenotype of ORNJ and related precursor states through data standardization to facilitate effective diagnosis, monitoring, and multidisciplinary management of ORNJ...
April 9, 2024: medRxiv
#24
JOURNAL ARTICLE
Firehiwot Assefa Eshete, Yetenayet B Tola, Chala G Kuyu, Kassaye Tolessa, Dinka Mulugeta, Shitaye Gure
Ethiopia's economy heavily relies on coffee, the country's primary export. However, there is a need for improvement in the current packaging materials for parchment coffee during extended storage. An experiment was conducted to evaluate the effectiveness of four different packaging materials (Jute, Woven Polypropylene internally lined with low-density propylene, Grain Pro, and Purdue Improved Crop Storage) on the quality of three brands of Parchment Coffee (Limu, Sidama, and Yirgacheffe) stored for 12 months...
April 30, 2024: Heliyon
#25
JOURNAL ARTICLE
Peddakapu Kurukuri, Mohd Rusllim Mohamed, Pavan Harika Raavi, Yogendra Arya
Although hybrid wind-biomass-battery-solar energy systems have enormous potential to power future cities sustainably, there are still difficulties involved in their optimal planning and designing that prevent their widespread adoption. This article aims to develop an optimal sizing of microgrids by incorporating renewable energy (RE) technologies for improving cost efficiency and sustainability in urban areas. Diverse RE technologies such as photovoltaic (PV) systems, biomass, batteries, wind turbines, and converters are considered for system configuration to obtain this goal...
April 22, 2024: Environmental Science and Pollution Research International
#26
JOURNAL ARTICLE
(no author information available yet)
Far-advanced gastric cancer has always been a challenging problem in clinical treatment and a key direction for breakthrough research. Non-surgical treatments are primarily managed in patients with far-advanced gastric cancer. However, with the advancement of therapeutic methods in recent years, tumor foci can be significantly regressed after effective preoperative treatment, in prospect ofregaining the opportunity of radical gastrectomy. In the surgical field, laparoscopic surgery, as one of the routine methods for gastric cancer, has proven effective in the treatment of initially resectable gastric cancer...
April 23, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
#27
JOURNAL ARTICLE
Arindam Das, Gouranga Jana, Shukdeb Sing, Anirban Basu
Interaction under amyloidogenic condition between naturally occurring protoberberine alkaloid palmatine and hen egg white lysozyme was executed by adopting spectrofluorometric and theoretical molecular docking and dynamic simulation analysis. In spetrofluorometric method, different types of experiments were performed to explore the overall mode and mechanism of interaction. Intrinsic fluorescence quenching of lysozyme (Trp residues) by palmatine showed effective binding interaction and also yielded different binding parameters like binding constant, quenching constant and number of binding sites...
April 19, 2024: International Journal of Biological Macromolecules
#28
REVIEW
Lena Chan
More than half of the world's population live in cities, and they have benefitted from the ecosystem services provided by urban biodiversity. International conventions like the Convention on Biological Diversity have provided recommendations on how to engage local governments and cities in the implementation of their strategic plans. In parallel, recognizing this, cities conserve, restore and enhance biodiversity in many practical ways. A list of general strategies adopted by cities is presented. The rich and diverse experiences of eleven cities, i...
June 10, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
#29
REVIEW
Jan Scott, Frank Iorfino, William Capon, Jacob Crouse, Barnaby Nelson, Andrew M Chanen, Dominic Dwyer, Philippe Conus, Andreas Bechdolf, Aswin Ratheesh, Andrea Raballo, Alison Yung, Michael Berk, Sarah McKenna, Samuel Hockey, Alexis Hutcheon, Elizabeth Scott, Pat McGorry, Jai Shah, Ian B Hickie
Globally, 75% of depressive, bipolar, and psychotic disorders emerge by age 25 years. However, these disorders are often preceded by non-specific symptoms or attenuated clinical syndromes. Difficulties in determining optimal treatment interventions for these emerging mental disorders, and uncertainties about accounting for co-occurring psychopathology and illness trajectories, have led many youth mental health services to adopt transdiagnostic clinical staging frameworks. In this Health Policy paper, an international working group highlights ongoing challenges in applying transdiagnostic staging frameworks in clinical research and practice, and proposes refinements to the transdiagnostic model to enhance its reliability, consistent recording, and clinical utility...
April 18, 2024: Lancet Psychiatry
#30
JOURNAL ARTICLE
Sophie Logan, Christine A Riedy, Kadriye Hargett, Negin Katebi
BACKGROUND: Did the COVID-19 pandemic affect orthodontists' use of remote monitoring platforms? The goal of this research was to examine orthodontists' experiences implementing remote monitoring platforms before, during, and after the initial COVID-19 lockdown. METHODS: In this descriptive cross-sectional survey study, an electronic, anonymous questionnaire consisting of a series of 31 short-answer and multiple-choice questions was administered to an international sampling of practicing orthodontists...
April 20, 2024: BMC Oral Health
#31
JOURNAL ARTICLE
Frederick L Philippe, Noémie Carbonneau, Annabelle Fortin, Valerie Guilbault, Nabil Bouizegarene, Juliana Mazanek Antunes, Sook Ning Chua
The cognitive mechanisms through which specific life events affect the development and maintenance of eating disorders (ED) have received limited attention in the scientific literature. The present research aims to address this gap by adopting a memory perspective to explore the type of life events associated with eating psychopathology and how these events are encoded and reconstructed as memories. Two studies (n = 208 and n = 193) were conducted to investigate the relationship between specific memories and eating disorder psychopathology...
April 18, 2024: Appetite
#32
JOURNAL ARTICLE
Masoud Siaghi, Ayoob Karimizade, Amir Mellati, Majid Saeedi, Fereshteh Talebpour Amiri, Shakiba Kalhori, Somayeh Shahani
In clinical practice, wound care has always been challenging. Hydrogels play a key role in facilitating active wound recovery by absorbing exudates, maintaining moisture, and alleviating pain through cooling. In this study, type I collagen was isolated from the skin of crucian carp (Carassius carassius) and verified by amino acid analysis, FTIR, and SDS-PAGE. By adopting a new approach, luteolin was added to collagen hydrogels in situ after being dissolved in an alkaline solution. XRD and SEM confirmed the luteolin was incorporated and entirely distributed throughout the hydrogel...
April 18, 2024: International Journal of Pharmaceutics
#33
JOURNAL ARTICLE
Mark Griffiths, Dunia Hatabah, Patrick Sullivan, Grace Mantus, Travis Sanchez, Maria Zlotorzynska, Stacy Heilman, Andres Camacho-Gonzalez, Deborah Leake, Rawan Korman, Mimi Le, Mehul Suthara, Jens Wrammert, Miriam B Vos, Claudia R Morris
OBJECTIVES: Determine SARS-CoV-2 IgG antibody incidence over time in unvaccinated pediatric healthcare workers (pHCWs). DESIGN: Prospective longitudinal cohort of unvaccinated pHCWs measuring incidence of new infection after initial prevalence was established at 4.1% with seropositive predominance in emergency department (ED)-based pHCWs. Serum samples were collected at follow-up visits to detect new SARS-CoV-2 seropositivity. Univariate analysis was performed to estimate different incidence rates between participant demographics, job, employment location and community risk factors...
April 17, 2024: International Journal of Infectious Diseases: IJID
#34
REVIEW
Turo Nurmikko, Dave Mugan, Angela Leitner, Frank J P M Huygen
OBJECTIVES: Quantitative sensory testing (QST) has been used for decades to study sensory abnormalities in multiple conditions in which the somatosensory system is compromised, including pain. It is commonly used in pharmacologic studies on chronic pain but less so in conjunction with neuromodulation. This review aims to assess the utility of QST in spinal cord stimulation (SCS) protocols. MATERIALS AND METHODS: For this narrative review, we searched PubMed for records of studies in which sensory testing has been performed as part of a clinical study on SCS from 1975 onward until October 2023...
April 18, 2024: Neuromodulation: Journal of the International Neuromodulation Society
#35
JOURNAL ARTICLE
Jiaman Yang, Yulin Xie, Zhikuan Xia, Shuaifei Ji, Xin Yang, Danxia Yue, Yuanyuan Liu, Rongya Yang, Yunlong Fan
BACKGROUND: Neutrophils rapidly accumulate in large numbers at sites of tissue damage, exhibiting not only their well-known bactericidal capabilities but also playing crucial roles in angiogenesis and tissue repair. While exosomes derived from human umbilical cord mesenchymal stem cells (HucMSC-Exo) have emerged as a promising therapeutic tool, their exact mechanisms of action remain partly elusive. We hypothesize that HucMSC-Exo treatment may modulate neutrophil phenotypes, thereby significantly influencing wound healing outcomes...
2024: International Journal of Nanomedicine
#36
REVIEW
Giulia A Albanese, Anna Bucchieri, Jessica Podda, Andrea Tacchino, Stefano Buccelli, Elena De Momi, Matteo Laffranchi, Kailynn Mannella, Michael W R Holmes, Jacopo Zenzeri, Lorenzo De Michieli, Giampaolo Brichetto, Giacinto Barresi
The robotics discipline is exploring precise and versatile solutions for upper-limb rehabilitation in Multiple Sclerosis (MS). People with MS can greatly benefit from robotic systems to help combat the complexities of this disease, which can impair the ability to perform activities of daily living (ADLs). In order to present the potential and the limitations of smart mechatronic devices in the mentioned clinical domain, this review is structured to propose a concise SWOT (Strengths, Weaknesses, Opportunities, and Threats) Analysis of robotic rehabilitation in MS...
2024: Frontiers in Robotics and AI
#37
JOURNAL ARTICLE
Liang-Pin Li, Li-Yun Yuan, De-Shen Mao, Xia Hua, Xiao-Yong Yuan
AIM: To analysis of research hotspots and trends on the application of premium intraocular lens (PIOLs) in the past 2 decades. METHODS: The literature search was performed on the Web of Science and included PIOLs studies published between January 2000 and December 2022. The retrieved literature was collated and analyzed by R-tool's Bibliometrix package, CitNetExplorer, CiteSpace and other software. RESULTS: A total of 1801 articles about PIOLs were obtained, most of which were published in Spain and the United States...
2024: International Journal of Ophthalmology
#38
REVIEW
Joseph B John, William K Gray, Kieran O'Flynn, Tim W R Briggs, John S McGrath
The Getting It Right First Time (GIRFT) programme is a quality improvement initiative covering the National Health Service in England. The programme aims to standardise clinical practices and improve patient and system level outcomes by utilising data-driven insights and clinically-led recommendations. There are GIRFT workstreams for every medical and surgical specialty, including urology. Defining features of the GIRFT methodology are that it is clinically led by experienced clinicians, data-driven, and specialty specific...
April 18, 2024: BJU International
#39
JOURNAL ARTICLE
Selma Celikovic, Johannes Poms, Johannes Khinast, Martin Horn, Jakob Rehrl
Continuous manufacturing of pharmaceuticals offers several benefits, such as increased production efficiency, enhanced product quality control, and lower environmental footprint. To fully exploit these benefits, standard operation mode (production processes with no or minimal disturbance mitigation measures) should be supported by adopting novel quality-by-control (QbC) methodologies. The paper at hand is the first part of a study focused on developing QbC algorithms for optimizing twin-screw wet granulation in the industrial manufacturing line ConsiGmaTM -25, specifically addressing granule composition...
April 16, 2024: International Journal of Pharmaceutics
#40
REVIEW
Elena Xerxa, Jürgen Bajorath
The continued growth of data from biological screening and medicinal chemistry provides opportunities for data-driven experimental design and decision making in early-phase drug discovery. Approaches adopted from data science help to integrate internal and public domain data and extract knowledge from historical in-house data. Protein kinase (PK) drug discovery is an exemplary area where large amounts of data are accumulating, providing a valuable knowledge base for discovery projects. Herein, the evolution of PK drug discovery and development of small molecular PK inhibitors (PKIs) is reviewed, highlighting milestone developments in the field and discussing exemplary studies providing a basis for increasing data orientation of PK discovery efforts...
April 15, 2024: European Journal of Medicinal Chemistry
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