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https://www.readbyqxmd.com/read/29684812/quantitative-evaluation-of-the-matrix-effect-in-bioanalytical-methods-based-on-lc-ms-a-comparison-of-two-approaches
#1
Piotr J Rudzki, Elżbieta Gniazdowska, Katarzyna Buś-Kwaśnik
Liquid chromatography coupled to mass spectrometry (LC-MS) is a powerful tool for studying pharmacokinetics and toxicokinetics. Reliable bioanalysis requires the characterization of the matrix effect, i.e. influence of the endogenous or exogenous compounds on the analyte signal intensity. We have compared two methods for the quantitation of matrix effect. The CVs(%) of internal standard normalized matrix factors recommended by the European Medicines Agency were evaluated against internal standard normalized relative matrix effects derived from Matuszewski et al...
April 6, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29684313/breathing-and-coding-a-bit-easier-changes-to-international-classification-of-disease-coding-for-pulmonary-hypertension
#2
REVIEW
Stephen C Mathai, Sherin Mathew
International Classification of Disease (ICD) coding system is broadly utilized by healthcare providers, hospitals, healthcare payers, and governments to track health trends and statistics at the global, national, and local levels and to provide a reimbursement framework for medical care based upon diagnosis and severity of illness. The current iteration of the ICD system, ICD-10, was implemented in 2015. While many changes to the prior ICD-9 system were included in the ICD-10 system, the newer revision failed to adequately reflect advances in the clinical classification of certain diseases such as pulmonary hypertension (PH)...
April 20, 2018: Chest
https://www.readbyqxmd.com/read/29683089/medical-students-perceptions-of-general-practice-as-a-career-a-phenomenological-study-using-socialisation-theory
#3
Katherine Reid, Hugh Alberti
The ageing population and push to community care has significantly increased the workload of General Practitioners (GPs) in the UK and internationally. In an attempt to tackle this, NHS England has promised 5000 more GPs by 2020/21; however, recruitment is in crisis with GP training posts remaining unfilled. Little research has been carried out to assess the fundamental questions of what medical students' perceptions of General Practice are and what shapes their perceptions at medical school. We aimed to explore medical students' conceptualisations of being a GP and specifically the role of the medical school in shaping their perceptions...
April 23, 2018: Education for Primary Care
https://www.readbyqxmd.com/read/29682996/the-latin-stranger-science-or-l-anthropologie-among-the-lusitanians
#4
Ricardo Roque
This essay traces the connected histories of Portuguese and French anthropology in the late nineteenth century. By looking at a Portuguese scientific institution, the Carlos Ribeiro Society, it considers how French race science, known as anthropologie, was adopted and adapted across the European Latin world as a type of "stranger-science." That is: as an authoritative outsider scientific formation, installed into national terrain in accordance with insider strategies for turning foreign elements into native forms of scientific sovereignty and modernity...
April 1, 2018: History of Science; An Annual Review of Literature, Research and Teaching
https://www.readbyqxmd.com/read/29681042/the-privacy-and-security-implications-of-open-data-in-healthcare
#5
Shinji Kobayashi, Thomas B Kane, Chris Paton
OBJECTIVE:  The International Medical Informatics Association (IMIA) Open Source Working Group (OSWG) initiated a group discussion to discuss current privacy and security issues in the open data movement in the healthcare domain from the perspective of the OSWG membership. METHODS:  Working group members independently reviewed the recent academic and grey literature and sampled a number of current large-scale open data projects to inform the working group discussion...
April 22, 2018: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29680303/efficacy-of-carotid-artery-stenting-by-the-universal-protection-method
#6
Shunsaku Goto, Tomotaka Ohshima, Kyozo Kato, Takashi Izumi, Toshihiko Wakabayashi
PURPOSE: To avoid distal plaques embolization during carotid artery stenting, we developed Universal Protection Method that combined the use of a proximal common carotid artery balloon, an external carotid artery balloon, and a distal internal carotid artery filter, with continuous flow reversal to the femoral vein. Herein, we assessed the efficacy of the Universal Protection Method by comparing stenting outcomes before and after its introduction. MATERIALS AND METHODS: We assessed outcomes for 115 cases before and 41 cases after the Universal Protection Method was adopted (non-Universal Protection Method and Universal Protection Method groups, respectively)...
April 18, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29679156/phthalates-removal-efficiency-in-different-wastewater-treatment-technology-in-the-eastern-cape-south-africa
#7
Taofeek Salaudeen, Omobola Okoh, Foluso Agunbiade, Anthony Okoh
The removal capacity of different wastewater treatment plant (WWTP) technologies adopted in rural areas for phthalate was investigated in the Eastern Cape, South Africa. Wastewater samples collected from three selected WWTPs which use activated sludge (AS), trickling filter (TF), and oxidation pond (OP) technology were extracted using the solid-phase extraction method followed by gas chromatography-mass spectrometry (GC-MS) analysis. The six selected phthalate esters (PAEs) dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), benzyl butyl phthalate (BBP), di(2-ethyl hexyl) phthalate (DEHP), and di-n-octyl phthalate (DOP) were detected in all the samples collected from the WWTPs...
April 20, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29678051/interoperability-assets-for-patient-summary-components-a-gap-analysis
#8
Kai U Heitmann, Giorgio Cangioli, Marcello Melgara, Catherine Chronaki
The International Patient Summary (IPS) standards aim to define the specifications for a minimal and non-exhaustive Patient Summary, which is specialty-agnostic and condition-independent, but still clinically relevant. Meanwhile, health systems are developing and implementing their own variation of a patient summary while, the eHealth Digital Services Infrastructure (eHDSI) initiative is deploying patient summary services across countries in the Europe. In the spirit of co-creation, flexible governance, and continuous alignment advocated by eStandards, the Trillum-II initiative promotes adoption of the patient summary by engaging standards organizations, and interoperability practitioners in a community of practice for digital health to share best practices, tools, data, specifications, and experiences...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677976/physicians-perceptions-about-phr-for-inpatients-qualitative-study
#9
Julia Frangella, Gabriela Garcia, Lucila Bruchanski, María Smith, Janine Sommer, Romina Rapisarda, Daniel Luna
The aim of this article was to know physician perceptions about a PHR for inpatients and to examine ways to take advantage of possible functionalities that could help physicians in their daily workflow. This qualitative research, was conducted through: two focus groups and nine personal interviews performed with internal medicine physicians. Collection and analysis of obtained data was carried out by two professionals. It was made by the codification and categorization of data based on a process of constant comparison...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29675504/surgical-treatment-of-objective-patellar-instability-long-term-results
#10
Massimo Berruto, Francesco Mattia Uboldi, Paolo Ferrua, Giovanni Vergottini, Andrea Manunta
Purpose  To evaluate the long-term results of classical "à la carte" surgical treatment of objective patellar instability as proposed by Dejour in 1987. Methods  A multicentric retrospective study was conducted evaluating patients that underwent surgical procedure with a 10-year minimum follow-up (mean 12.7; range, 10-15). Surgical procedures were medial transfer of the tibial tubercle transfer according to Elmslie and Trillat et al in 38 cases, plasty of the vastus medialis obliquus according to Insall in 15 cases, open lateral retinacular release in 13 cases, capsuloplasty in 3 cases, and trochleoplasty in 1 case...
March 2018: Joints
https://www.readbyqxmd.com/read/29673604/concurrence-of-big-data-analytics-and-healthcare-a-systematic-review
#11
REVIEW
Nishita Mehta, Anil Pandit
BACKGROUND: The application of Big Data analytics in healthcare has immense potential for improving the quality of care, reducing waste and error, and reducing the cost of care. PURPOSE: This systematic review of literature aims to determine the scope of Big Data analytics in healthcare including its applications and challenges in its adoption in healthcare. It also intends to identify the strategies to overcome the challenges. DATA SOURCES: A systematic search of the articles was carried out on five major scientific databases: ScienceDirect, PubMed, Emerald, IEEE Xplore and Taylor & Francis...
June 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29673192/management-control-systems-and-clinical-experience-of-managers-in-public-hospitals
#12
Rogério Joao Lunkes, David Naranjo-Gil, Ernesto Lopez-Valeiras
Healthcare authorities are encouraging managers in hospitals to acquire clinical experience and knowledge in order to better carry out and coordinate healthcare service delivery. The main objective of this paper is to analyse how the clinical experience of hospital managers is related to public health institutions’ performance. It is proposed that the effect of the clinical experience on operative and financial organizational performance is indirect through the mediating variables of perceived utility of management information and horizontal management control system...
April 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29672845/drug-induced-proarrhythmia-and-torsade-de-pointes-a-primer-for-students-and-practitioners-of-medicine-and-pharmacy
#13
REVIEW
J Rick Turner, Ignacio Rodriguez, Emily Mantovani, Gary Gintant, Peter R Kowey, Ralph J Klotzbaugh, Krishna Prasad, Philip T Sager, Norman Stockbridge, Colette Strnadova
Multiple marketing withdrawals due to proarrhythmic concerns occurred in the United States, Canada, and the United Kingdom in the late 1980s to early 2000s. This primer reviews the clinical implications of a drug's identified proarrhythmic liability, the issues associated with these safety-related withdrawals, and the actions taken by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) and by regulatory agencies in terms of changing drug development practices and introducing new nonclinical and clinical tests to asses proarrhythmic liability...
April 19, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29671333/key-attributes-of-global-partnerships-in-food-and-nutrition-to-align-research-agendas-and-improve-public-health
#14
Robert F Bertolo, Eric Hentges, Mary-Jo Makarchuk, Ashleigh K A Wiggins, Heather Steele, Julia Levin, Andrea Grantham, Leah Gramlich, David W L Ma
Partnerships among academia, government and industry have emerged in response to global challenges in food and nutrition. At a workshop reviewing international partnerships, we concluded that to build a partnership, partners must establish a common goal, identify barriers and engage all stakeholders to ensure project sustainability. To be effective, partnerships must synchronize methodologies and adopt evidence-based processes, and be led by governmental or non-profit organizations to ensure trust among partners and with the public...
April 19, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29669922/origin-antigenicity-and-function-of-a-secreted-form-of-orf2-in-hepatitis-e-virus-infection
#15
Xin Yin, Dong Ying, Sébastien Lhomme, Zimin Tang, Christopher M Walker, Ningshao Xia, Zizheng Zheng, Zongdi Feng
The enterically transmitted hepatitis E virus (HEV) adopts a unique strategy to exit cells by cloaking its capsid (encoded by the viral ORF2 gene) and circulating in the blood as "quasi-enveloped" particles. However, recent evidence suggests that the majority of the ORF2 protein present in the patient serum and supernatants of HEV-infected cell culture exists in a free form and is not associated with virus particles. The origin and biological functions of this secreted form of ORF2 (ORF2S ) are unknown...
April 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29669709/implementing-an-open-source-electronic-health-record-system-in-kenyan-health-care-facilities-case-study
#16
Naomi Muinga, Steve Magare, Jonathan Monda, Onesmus Kamau, Stuart Houston, Hamish Fraser, John Powell, Mike English, Chris Paton
BACKGROUND: The Kenyan government, working with international partners and local organizations, has developed an eHealth strategy, specified standards, and guidelines for electronic health record adoption in public hospitals and implemented two major health information technology projects: District Health Information Software Version 2, for collating national health care indicators and a rollout of the KenyaEMR and International Quality Care Health Management Information Systems, for managing 600 HIV clinics across the country...
April 18, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29668771/ivth-brazilian-consensus-conference-on-helicobacter-pylori-infection
#17
Luiz Gonzaga Vaz Coelho, James Ramalho Marinho, Robert Genta, Laercio Tenório Ribeiro, Maria do Carmo Friche Passos, Schlioma Zaterka, Paulo Pimentel Assumpção, Alfredo José A Barbosa, Ricardo Barbuti, Lucia Libanês Braga, Helenice Breyer, Aloisio Carvalhaes, Décio Chinzon, Marcelo Cury, Gerson Domingues, Jorge Luiz Jorge, Ismael Maguilnik, Frederico Passos Marinho, Joaquim Prado de Moraes-Filho
Significant progress has been obtained since the III Brazilian Consensus Conference on H. pylori infection held in 2012, in Bento Gonçalves, Brazil, and justify a fourth meeting to establish updated guidelines on the current management of H. pylori infection. Therefore, the Núcleo Brasileiro para Estudo do Helicobacter pylori e Microbiota (NBEHPM), association linked to Brazilian Federation of Gastroenterology (FBG) held its fourth meeting again in Bento Gonçalves, RS, Brazil, on August 25-27, 2017. Twenty-six delegates, including gastroenterologists, endoscopists, and pathologists from the five regions of Brazil as well as one international guest from the United States, participated in the meeting...
April 16, 2018: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/29668473/the-history-of-bone-tumour-treatment-and-the-state-of-the-art-in-vienna
#18
Rainer Kotz
PURPOSES: Bone tumours have been a tragedy for the patient in any time period. In the majority of the cases it occurs in children or young adults. In the past the affected limbs could not be spared and the overall prognosis was poor. METHODS: Chemotherapy successfully introduced for the purpose of overcoming the poor overall prognosis (Rosen and Jaffe) and tumour prostheses were invented for the purpose of salvaging the affected limbs (Marcove, Scales, Campanacci, Sivas, Salzer)...
December 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/29666889/surgical-strategy-for-benign-lesions-in-proximal-femur-internal-fixation-or-endoprosthetic-replacement
#19
Hongyuan Liu, Xiang Fang, Zeping Yu, Yun Lang, Yan Xiong, Hong Duan
PURPOSE: The purpose of this study was to explore the indications for the two most frequently applied surgical procedures for benign lesions in the proximal femur. METHODS: We retrospectively reviewed 142 patients with benign lesions in the proximal femur from January 2010 to January 2015. Internal fixation (IF) was adopted in 110 patients, while endoprosthetic replacement (EPR) was applied in 32 patients. Clinical data, including operation time, blood loss, hospitalization time, and hospitalization expenses, were compared between the groups...
April 17, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29665784/development-and-psychometric-testing-of-an-abridged-version-of-dundee-ready-educational-environment-measure-dreem
#20
Kathiresan Jeyashree, Hemant Deepak Shewade, Soundappan Kathirvel
BACKGROUND: Dundee Ready Educational Environment Measure (DREEM) is a 50-item tool to assess the educational environment of medical institutions as perceived by the students. This cross-sectional study developed and validated an abridged version of the DREEM-50 with an aim to have a less resource-intensive (time, manpower), yet valid and reliable, version of DREEM-50 while also avoiding respondent fatigue. METHODS: A methodology similar to that used in the development of WHO-BREF was adopted to develop the abridged version of DREEM...
April 17, 2018: Environmental Health and Preventive Medicine
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