Chunmei Cai, Yuye Huang, Liyan Li, Kai Kei Miu, Zhangting Wang, Yujie Deng, Yanzhen Cai, Jinxiu Li, Liang Wu, Hepeng Zhu, Yang Gao, Jun Chen, Wende Xiao, Li Lu
BACKGROUND: Ankylosing spondylitis (AS) is a chronic autoimmune arthritis that mainly affects spine joints. To date, the pathogenesis of AS remains unclear, although immune cells and innate immune response cytokines have been suggested to be crucial players. METHODS: By adopting a single-cell RNA sequencing approach in the AS cynomolgus model, we profiled and characterized PBMC proportions along disease progression. RESULTS: Here, our primary focus was on the activation of an immune cascade-initiating lymphocyte subtype known as CD4+ CXCR5+ T follicular helper (Tfh) cells...
April 16, 2024: International Immunopharmacology