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JOURNAL ARTICLE
Nouf Alharbi, Lewis Mackenzie, Dimitrios Pezaros
The emergence of the Industrial Internet of Things (IIoT) has accelerated the adoption of Industrial Wireless Sensor Networks (IWSNs) for numerous applications. Effective communication in such applications requires reduced end-to-end transmission time, balanced energy consumption and increased communication reliability. Graph routing, the main routing method in IWSNs, has a significant impact on achieving effective communication in terms of satisfying these requirements. Graph routing algorithms involve applying the first-path available approach and using path redundancy to transmit data packets from a source sensor node to the gateway...
October 1, 2022: Sensors
#22
JOURNAL ARTICLE
Leila Amiri-Farahani, Maryam Gharacheh, Narges Sadeghzadeh, Hamid Peyravi, Sally Pezaro
BACKGROUND & OBJECTIVE: Continuity of midwifery-led care during labour and birth is considered optimal. To ensure its sustainability in practice where limited evidence is available, the aim of the present study was to explore midwives' lived experiences of delivering continuous midwife-led intrapartum care. METHODS: This study took a qualitative approach in meeting its aim. Participants were midwives working in the labour wards of private and public hospitals in Iran...
September 23, 2022: BMC Pregnancy and Childbirth
#23
JOURNAL ARTICLE
Seyedeh Robab Mousavi, Leila Amiri-Farahani, Shima Haghani, Sally Pezaro
BACKGROUND AND AIM: Rates of cesarean section in Iran are unnecessarily high largely due to fear of childbirth (FOC), yet this may be reduced through education. Iranian women are keen to obtain information about pregnancy and birth online though sources may not be reliable. Consequently, the present study aimed to compare the effect of childbirth preparation courses delivered both online via the social media platform 'Telegram' and in-person on pregnancy experience, FOC, birth preference, and mode of birth...
2022: PloS One
#24
JOURNAL ARTICLE
Sally Pezaro, Karen Maher, Elizabeth Bailey, Gemma Pearce
OBJECTIVE: Use a pragmatic mixed methods approach to provide a rich understanding of the perceptions of Problematic Substance Use (PSU) and the influences of PSU on the mental and physical health of midwives registered with the Nursing and Midwifery Council (NMC). DESIGN: A confidential and anonymous self-administered online survey was employed to encourage wider participation. SETTING: United Kingdom PARTICIPANTS: Midwives (n=623) registered with the NMC MEASUREMENTS: Open text responses were invited throughout the survey...
September 2022: Midwifery
#25
RANDOMIZED CONTROLLED TRIAL
Nicholas D James, Noel W Clarke, Adrian Cook, Adnan Ali, Alex P Hoyle, Gerhardt Attard, Christopher D Brawley, Simon Chowdhury, William R Cross, David P Dearnaley, Johann S de Bono, Carlos Diaz-Montana, Duncan Gilbert, Silke Gillessen, Clare Gilson, Rob J Jones, Ruth E Langley, Zafar I Malik, David J Matheson, Robin Millman, Chris C Parker, Cheryl Pugh, Hannah Rush, J Martin Russell, Dominik R Berthold, Michelle L Buckner, Malcolm D Mason, Alastair W S Ritchie, Alison J Birtle, Susannah J Brock, Prantik Das, Dan Ford, Joanna Gale, Warren Grant, Emma K Gray, Peter Hoskin, Mohammad M Khan, Caroline Manetta, Neil J McPhail, Joe M O'Sullivan, Omi Parikh, Carla Perna, Carmel J Pezaro, Andrew S Protheroe, Angus J Robinson, Sarah M Rudman, Denise J Sheehan, Narayanan N Srihari, Isabel Syndikus, Jacob S Tanguay, Carys W Thomas, Salil Vengalil, John Wagstaff, James P Wylie, Mahesh K B Parmar, Matthew R Sydes
Abiraterone acetate plus prednisolone (AAP) previously demonstrated improved survival in STAMPEDE, a multiarm, multistage platform trial in men starting long-term hormone therapy for prostate cancer. This long-term analysis in metastatic patients was planned for 3 years after the first results. Standard-of-care (SOC) was androgen deprivation therapy. The comparison randomised patients 1:1 to SOC-alone with or without daily abiraterone acetate 1000 mg + prednisolone 5 mg (SOC + AAP), continued until disease progression...
August 1, 2022: International Journal of Cancer. Journal International du Cancer
#26
JOURNAL ARTICLE
Alejandro Llorens-Carrodeguas, Stefanos G Sagkriotis, Cristina Cervelló-Pastor, Dimitrios P Pezaros
The deployment of modern applications, like massive Internet of Things (IoT), poses a combination of challenges that service providers need to overcome: high availability of the offered services, low latency, and low energy consumption. To overcome these challenges, service providers have been placing computing infrastructure close to the end users, at the edge of the network. In this vein, single board computer (SBC) clusters have gained attention due to their low cost, low energy consumption, and easy programmability...
October 28, 2021: Sensors
#27
JOURNAL ARTICLE
Sally Pezaro, Martin Jenkins, Martin Bollard
BACKGROUND: There are calls to ensure that evidence-based practice is enabled for every midwife and nurse by means of education, research, leadership and access to evidence. Concurrently, there is a global call for universities to foster 'Research Inspired Teaching'. Yet such teaching must first be defined and may usefully be developed, delivered, and evaluated as part of a framework approach. OBJECTIVE: To co-create a uniform definition of 'Research Inspired Teaching' and a framework for developing, delivering, and evaluating it...
January 2022: Nurse Education Today
#28
JOURNAL ARTICLE
Leila Amiri-Farahani, Soroor Parvizy, Eesa Mohammadi, Mohsen Asadi-Lari, Ziba Taghizadeh, Sally Pezaro
BACKGROUND: There is insufficient physical activity among women. Yet the implementation of effective, multilevel, and evidence-based interventions may address this. Since the lifestyle of individuals is formed in many different social, physical and cultural contexts, it will be necessary in designing such interventions to involve many stakeholders. Consequently, the present study took a mixed method action research approach in developing, implementing and evaluating a bespoke program to improve physical activity among women...
October 26, 2021: BMC Sports Science, Medicine and Rehabilitation
#29
JOURNAL ARTICLE
Katayon Ahmadi, Leila Amiri-Farahani, Shima Haghani, Seyedeh Batool Hasanpoor-Azghady, Sally Pezaro
OBJECTIVES: To determine the intensity, barriers and correlates of physical activity (PA) in Iranian pregnant women. METHODS: This cross-sectional study was carried out with 300 eligible pregnant women referred to the Ilam health centres and bases using stratified random sampling with proportional allocation. Data collection tools included a demographic and obstetrical history questionnaire, the Pregnancy Physical Activity Questionnaire and the Exercise Benefits/Barriers Scale...
2021: BMJ Open Sport & Exercise Medicine
#30
JOURNAL ARTICLE
S Pezaro, K Maher, E Bailey, G Pearce
BACKGROUND: Problematic substance use (PSU) poses occupational, personal and professional risks. As an occupational group, midwives have been under-represented in research on PSU. AIMS: The aim of this study was to assess self-reported occurrences of PSU, help-seeking behaviours and barriers, and perceptions of impairment in UK-based midwives. METHODS: Self-selecting registered midwives were anonymously surveyed using the Tobacco, Alcohol, Prescription Medications, and Substance Use/Misuse (TAPS) tool, the Perceptions of Nursing Impairment Inventory (PNII) and open-ended/closed questions...
December 24, 2021: Occupational Medicine
#31
JOURNAL ARTICLE
Edmond M Kwan, Lavinia Spain, Angelyn Anton, Chun L Gan, Linda Garrett, Deborah Chang, Elizabeth Liow, Caitlin Bennett, Tiantian Zheng, Jianjun Yu, Chao Dai, Pan Du, Shidong Jia, Heidi Fettke, Claire Abou-Seif, Gargi Kothari, Mark Shaw, Phillip Parente, Carmel Pezaro, Ben Tran, Shankar Siva, Arun A Azad
BACKGROUND: Immune checkpoint inhibitor monotherapy in metastatic castration-resistant prostate cancer (mCRPC) has produced modest results. High-dose radiotherapy may be synergistic with checkpoint inhibitors. OBJECTIVE: To evaluate the efficacy and safety of the PD-L1 inhibitor avelumab with stereotactic ablative body radiotherapy (SABR) in mCRPC. DESIGN, SETTING, AND PARTICIPANTS: From November 2017 to July 2019, this prospective phase 2 study enrolled 31 men with progressive mCRPC after at least one prior androgen receptor-directed therapy...
September 4, 2021: European Urology
#32
JOURNAL ARTICLE
Gail P Risbridger, Ashlee K Clark, Laura H Porter, Roxanne Toivanen, Andrew Bakshi, Natalie L Lister, David Pook, Carmel J Pezaro, Shahneen Sandhu, Shivakumar Keerthikumar, Rosalia Quezada Urban, Melissa Papargiris, Jenna Kraska, Heather B Madsen, Hong Wang, Michelle G Richards, Birunthi Niranjan, Samantha O'Dea, Linda Teng, William Wheelahan, Zhuoer Li, Nicholas Choo, John F Ouyang, Heather Thorne, Lisa Devereux, Rodney J Hicks, Shomik Sengupta, Laurence Harewood, Mahesh Iddawala, Arun A Azad, Jeremy Goad, Jeremy Grummet, John Kourambas, Edmond M Kwan, Daniel Moon, Declan G Murphy, John Pedersen, David Clouston, Sam Norden, Andrew Ryan, Luc Furic, David L Goode, Mark Frydenberg, Mitchell G Lawrence, Renea A Taylor
Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and systematic evaluation of candidate therapies. The PDX collection comprises 59 tumors collected from 30 patients between 2012-2020, coinciding with availability of abiraterone and enzalutamide. The PDXs represent the clinico-pathological and genomic spectrum of prostate cancer, from treatment-naïve primary tumors to castration-resistant metastases...
August 19, 2021: Nature Communications
#33
JOURNAL ARTICLE
Mitchell G Lawrence, Laura H Porter, Nicholas Choo, David Pook, Jeremy P Grummet, Carmel J Pezaro, Shahneen Sandhu, Susanne Ramm, Jennii Luu, Andrew Bakshi, David L Goode, Elaine Sanij, Richard B Pearson, Ross D Hannan, Kaylene J Simpson, Renea A Taylor, Gail P Risbridger, Luc Furic
Monotherapy with poly (ADP-ribose) polymerase (PARP) inhibitors is effective for the subset of castrate-resistant prostate cancer (CRPC) with defects in homologous recombination (HR) DNA repair. New treatments are required for the remaining tumours, and an emerging strategy is to combine PARP inhibitors with other therapies that induce DNA damage. Here we tested whether PARP inhibitors are effective for HR-proficient CRPC, including AR-null tumours, when used in combination with CX-5461, a small molecule that inhibits RNA polymerase I transcription and activates the DNA damage response, and has anti-tumour activity in early Phase I trials...
August 19, 2021: Molecular Cancer Therapeutics
#34
JOURNAL ARTICLE
Angelyn Anton, Shirley Wong, Julia Shapiro, Andrew Weickhardt, Arun Azad, Edmond M Kwan, Lavinia Spain, Ashray Gunjur, Javier Torres, Phillip Parente, Francis Parnis, Jeffrey Goh, Marie C Semira, Peter Gibbs, Ben Tran, Carmel Pezaro
INTRODUCTION: Bone metastases occur frequently in castration-resistant prostate cancer (CRPC) and may lead to skeletal-related events (SREs), including symptomatic skeletal events (SSEs). Bone-modifying agents (BMAs) delay SREs and SSEs. However, the real-world use of BMAs is debated given the absence of demonstrated survival advantage and potential adverse events (AEs). Our retrospective study examined BMA use and SSE rates in Australian patients with CRPC. METHODS: Patients with CRPC and bone metastases were identified from the electronic CRPC Australian Database...
July 31, 2021: European Journal of Cancer
#35
JOURNAL ARTICLE
Leila Amiri-Farahani, Katayon Ahmadi, Syedeh Batool Hasanpoor-Azghady, Sally Pezaro
BACKGROUND: Pregnancy can affect the amount of physical activity that women engage in, so ensuring adequate physical activity in pregnant women can be a challenge. Therefore, there is a need to explore and identify barriers to physical activity in this population. Consequently, this study was conducted in order to develop and validate a scale to assess barriers to physical activity in pregnant populations. METHODS: The study was conducted in two phases. During phase 1, a comprehensive review of the most relevant literature from electronic databases on barriers to physical activity was carried out and appropriate scale items were extracted using a deductive approach...
July 29, 2021: BMC Public Health
#36
JOURNAL ARTICLE
Heidi Fettke, Edmond M Kwan, Patricia Bukczynska, Jason A Steen, Maria Docanto, Nicole Ng, Phillip Parente, Andrew Mant, Siavash Foroughi, Carmel Pezaro, Christine Hauser, Tu Nguyen-Dumont, Melissa C Southey, Arun A Azad
BACKGROUND: The androgen receptor (AR) pathway-associated gene nuclear receptor coactivator 2 (NCOA2) has an established oncogenic role in early prostate cancer and likewise is a driver of metastatic disease and castration-resistant prostate cancer. However, its significance as a biomarker in metastatic castration-resistant prostate cancer (mCRPC), both alone and in conjunction with co-occurring AR alterations using a liquid biopsy approach has not been investigated. METHODS: Ninety-one patients were included in this study, (n = 68 receiving an androgen receptor pathway inhibitor and n = 23 receiving taxane chemotherapy)...
September 2021: Prostate
#37
JOURNAL ARTICLE
Sarah Chitongo, Sally Pezaro, Janet Fyle, Fiona Suthers, Helen Allan
PROBLEM: Childbearing women from ethnic minority groups in the United Kingdom (UK) have significantly poorer perinatal outcomes overall. BACKGROUND: Childbearing women from ethnic minority groups report having poorer experiences and outcomes in perinatal care, and health professionals report having difficulty in providing effective care to them. Yet barriers in relation to providing such care remain underreported. AIM: The aim of this study was to elicit midwives' insights in relation to the common barriers in providing effective perinatal care to women from ethnic minority groups with 'high risk' pregnancies and how to overcome these barriers...
March 2022: Women and Birth
#38
JOURNAL ARTICLE
Edmond M Kwan, Heidi Fettke, Megan Crumbaker, Maria M Docanto, Sarah Q To, Patricia Bukczynska, Andrew Mant, Nicole Ng, Siavash Foroughi, Lisa-Jane K Graham, Anne-Maree Haynes, Sarah Azer, Lisi Elizabeth Lim, Eva Segelov, Kate Mahon, Ian D Davis, Phillip Parente, Carmel Pezaro, Tilman Todenhöfer, Niranjan Sathianathen, Christine Hauser, Lisa G Horvath, Anthony M Joshua, Arun A Azad
BACKGROUND: As potent systemic therapies transition earlier in the prostate cancer disease course, molecular biomarkers are needed to guide optimal treatment selection for metastatic hormone-sensitive prostate cancer (mHSPC). The value of whole blood RNA to detect candidate biomarkers in mHSPC remains largely undefined. METHODS: In this cohort study, we used a previously optimised whole blood reverse transcription polymerase chain reaction assay to assess the prognostic utility [measured by seven-month undetectable prostate-specific antigen (PSA) and time to castration-resistance (TTCR)] of eight prostate cancer-associated gene transcripts in 43 mHSPC patients...
April 2021: Translational Andrology and Urology
#39
RANDOMIZED CONTROLLED TRIAL
M Annala, S Fu, J V W Bacon, J Sipola, N Iqbal, C Ferrario, M Ong, D Wadhwa, S J Hotte, G Lo, B Tran, L A Wood, J R Gingerich, S A North, C J Pezaro, J D Ruether, S S Sridhar, H M L Kallio, D J Khalaf, A Wong, K Beja, E Schönlau, S Taavitsainen, M Nykter, G Vandekerkhove, A A Azad, A W Wyatt, K N Chi
BACKGROUND: Treatment of poor prognosis metastatic castration-resistant prostate cancer (mCRPC) includes taxane chemotherapy and androgen receptor pathway inhibitors (ARPI). We sought to determine optimal treatment in this setting. PATIENTS AND METHODS: This multicentre, randomised, open-label, phase II trial recruited patients with ARPI-naive mCRPC and poor prognosis features (presence of liver metastases, progression to mCRPC after <12 months of androgen deprivation therapy, or ≥4 of 6 clinical criteria)...
July 2021: Annals of Oncology: Official Journal of the European Society for Medical Oncology
#40
MULTICENTER STUDY
Sabine Schmid, Aurelius Omlin, Celestia Higano, Christopher Sweeney, Nieves Martinez Chanza, Niven Mehra, Malou C P Kuppen, Himisha Beltran, Vincenza Conteduca, Daniel Vargas Pivato de Almeida, Fernando Cotait Maluf, William K Oh, Che-Kai Tsao, Oliver Sartor, Elisa Ledet, Giuseppe Di Lorenzo, Steven M Yip, Kim N Chi, Diletta Bianchini, Ugo De Giorgi, Aaron R Hansen, Tomasz M Beer, Pernelle Lavaud, Rafael Morales-Barrera, Marcello Tucci, Elena Castro, Kostas Karalis, Andries M Bergman, Mo Linh Le, Ursina Zürrer-Härdi, Carmel Pezaro, Hiroyoshi Suzuki, Andrea Zivi, Dirk Klingbiel, Sämi Schär, Silke Gillessen
Importance: DNA repair gene aberrations occur in 20% to 30% of patients with castration-resistant prostate cancer (CRPC), and some of these aberrations have been associated with sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition platinum-based treatments. However, previous trials assessing platinum-based treatments in patients with CRPC have mostly included a biomarker-unselected population; therefore, efficacy in these patients is unknown. Objective: To characterize the antitumor activity of platinum-based therapies in men with CRPC with or without DNA repair gene alterations...
October 1, 2020: JAMA Network Open
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