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Vitamin D older adults

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https://www.readbyqxmd.com/read/29233204/is-there-a-role-for-vitamin-d-in-supporting-cognitive-function-as-we-age
#1
Niamh Aspell, Brian Lawlor, Maria O'Sullivan
Globally, an estimated 46 million people are currently living with dementia and this figure is projected to increase 3-fold by 2050, highlighting this major public health concern and its substantial associated healthcare costs. With pharmacological treatment yet to reach fruition, the emphasis on evidence-based preventative lifestyle strategies is becoming increasingly important and several modifiable lifestyle factors have been identified that may preserve cognitive health. These include good cardiovascular health, physical activity, low alcohol intake, smoking and a healthy diet, with growing interest in vitamin D...
December 13, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29228152/effectiveness-of-nutritional-interventions-addressed-to-elderly-persons-umbrella-systematic-review-with-meta-analysis
#2
Andrea Poscia, Sonja Milovanovic, Daniele Ignazio La Milia, Mariusz Duplaga, Marcin Grysztar, Francesco Landi, Umberto Moscato, Nicola Magnavita, Agnese Collamati, Walter Ricciardi
Background: The number of Europeans aged over 65 will double between 2010 and 2060, reaching 30% of the European population. Nutrition is emerging as a key element of healthy life since both obesity and malnutrition are established risk factors for morbidity and disability. The aim of this umbrella review (UR) is to summarize the findings of all current systematic reviews (SRs) and meta-analyzes (MAs) on the effectiveness of nutritional intervention designed to promote healthy aging in older individuals...
December 8, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29225312/prevalence-and-trends-of-vitamin-d-deficiency-among-iranian-adults-a-longitudinal-study-from-2001-2013
#3
Hossein Khosravi-Boroujeni, Nizal Sarrafzadegan, Masoumeh Sadeghi, Hamidreza Roohafza, Shu-Kay Ng, Ali Pourmogaddas, Faruk Ahmed
Vitamin D deficiency/insufficiency is currently considered to be a re-emerging public health problem globally. This study was designed to determine the prevalence of vitamin D deficiency and insufficiency and to investigate its trend from 2001 to 2013 in a longitudinal study of Iranian adults. This study was part of a population-based, longitudinal ongoing study of Iranian healthy adults aged 35 y and older at baseline. Serum vitamin D level was assessed in a sub-sample of 370 subjects, who were apparently healthy at the time of recruitment in 2001 and were free from MetS, in three phases (2001, 2007 and 2013) during the 12-y study period...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29211007/contribution-of-dietary-supplements-to-nutritional-adequacy-in-various-adult-age-groups
#4
Jeffrey B Blumberg, Balz Frei, Victor L Fulgoni, Connie M Weaver, Steven H Zeisel
Many Americans have inadequate intakes of several nutrients. The Dietary Guidelines for Americans 2015-2020 specifically identified vitamins A, C, D and E, calcium, magnesium, iron, potassium, choline and fiber as "underconsumed nutrients". Based on nationally representative data in 10,698 adults from National Health and Nutrition Examination Surveys (NHANES), 2009-2012, assessments were made of age-group differences in the impact of dietary supplements on nutrient intake and inadequacies. Compared to food alone, use of any dietary supplement plus food was associated with significantly (p < 0...
December 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29205454/joint-mixed-effects-models-for-causal-inference-with-longitudinal-data
#5
Michelle Shardell, Luigi Ferrucci
Causal inference with observational longitudinal data and time-varying exposures is complicated due to the potential for time-dependent confounding and unmeasured confounding. Most causal inference methods that handle time-dependent confounding rely on either the assumption of no unmeasured confounders or the availability of an unconfounded variable that is associated with the exposure (eg, an instrumental variable). Furthermore, when data are incomplete, validity of many methods often depends on the assumption of missing at random...
December 4, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29197959/fractures-frequently-occur-in-older-cancer-patients-the-md-anderson-cancer-center-experience
#6
Beatrice J Edwards, Ming Sun, Xiaotao Zhang, Holly M Holmes, Juhee Song, Peter Khalil, Meghan Karuturi, Jay B Shah, Colin P Dinney, Robert F Gagel, Vicente Valero, Richard E Champlin, Debasish Tripathy, William A Murphy
PURPOSE AND INTRODUCTION: A growing number of cancer patients are older adults aged 65 years and older. Patients with cancer are at increased risk for developing osteoporosis, falls, and fractures. We sought to identify the incidence of fractures in older adults who underwent cancer care between January 2013 and December 2015. METHODS: A comprehensive geriatric assessment was performed, and bone densitometry was measured at baseline, with a 2-year follow-up. RESULTS: In this study, among 304 patients with gastrointestinal, urologic, breast, lung, and gynecologic cancers we evaluated, and who completed the bone density testing (n = 199), 80% had osteoporosis or low bone mass (osteopenia)...
December 2, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29188894/vitamin-d-and-the-mechanisms-circumstances-and-consequences-of-falls-in-older-adults-a-case-control-study
#7
G T Duval, P-Y Paré, J Gautier, S Walrand, M Dinomais, C Annweiler
OBJECTIVES: To determine i) whether cases of elderly fallers had lower serum 25-hydroxyvitamin D (25OHD) concentration than controls without history of falls; and ii) whether serum 25OHD concentration was associated with specific mechanisms, circumstances and consequences of falls. DESIGN: Case-control study with a 1:2 ratio. SETTING: Geriatric ward of the University Hospital of Angers, France, between February 2012 and March 2014. PARTICIPANTS: 216 inpatients (72 cases and 144 age- and gender-matched controls)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29188882/nutrient-intake-during-diet-induced-weight-loss-and-exercise-interventions-in-a-randomized-trial-in-older-overweight-and-obese-adults
#8
G D Miller, D P Beavers, D Hamm, S L Mihalko, S P Messier
OBJECTIVES: Dietary restriction in obese older adults undergoing weight loss may exacerbate nutrient deficiencies common in this group; the nutritional health of older adults is a factor in their quality of life, disability, and mortality. This study examined the effect of an 18-month weight loss program based in social cognitive theory incorporating partial meal replacements, on nutrient intake in older overweight and obese adults. DESIGN: The following analysis is from the Intensive Diet and Exercise for Arthritis (IDEA) trial, a single-blind, randomized controlled trial...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29188868/vitamin-d-deficiency-and-insufficiency-prevalence-in-the-west-of-ireland-a-retrospective-study
#9
J Delos Reyes, A Smyth, D Griffin, P O'Shea, S O'Keeffe, E C Mulkerrin
OBJECTIVES: Vitamin D plays an important role in calcium homeostasis and is essential for normal bone growth and remodeling. Previous studies of acutely ill and institutionalized older women in Galway revealed that vitamin D insufficiency is extremely common. We aimed to evaluate age and gender-related rates of vitamin D insufficiency and deficiency in adult patients attending their General Practitioners in the same region. DESIGN: A retrospective cohort study. SETTING: General practices in Galway, a city located on the west coast of Ireland, latitude 53...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29188857/assessing-the-relationship-between-vitamin-d-status-and-impairments-in-cognitive-and-physical-performance-in-older-adults-using-a-dual-task-physical-performance-test
#10
J Lopez, A Campa, J E Lewis, F G Huffman, J P Liuzzi, T Li, A H Martinez, S M Ferris, A Rasul, A Farooqi, A M Lopez Medrano, S E Atlas, E Tiozzo, J Konefal, J M Woolger
BACKGROUND: Vitamin D deficiency has been associated with an increased risk of falls in older adults. Several studies have demonstrated an association between vitamin D deficiency and gait and cognitive impairments, which are two risk factors for falls in the elderly. There is lack of research about the role of vitamin D in cognitive function in the context of mobility. OBJECTIVE: The purpose of this study was to evaluate the association between vitamin D status with the age-related changes in mobility through higher order cognitive function using a dual task physical performance test...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29181264/evaluation-of-bone-mineral-density-and-related-parameters-in-patients-with-haemophilia-a-single-center-cross-sectional-study
#11
Hatice Demet Kiper Unal, Melda Comert Ozkan, Fatos Dilan Atilla, Zuhal Demirci, Nur Soyer, Ilgin Yildirim Simsir, Ozgur Omur, Kazim Capaci, Guray Saydam, Fahri Sahin
Haemophilia has been associated with low bone mineral density (BMD) probably due to some predisposing factors. The aim of this study was to evaluate the relationship between BMD and potential clinical predictors in adult haemophilic patients. Fortynine patients with moderate and severe haemophilia were enrolled. BMD was measured by Dual Energy X-Ray Absorptiometry (DXA) and blood tests were performed for vitamin D, calcium, phosphore, alkaline phosphatase and parathormone levels. Functional Independence Score in Haemophilia (FISH) and Haemophilia Joint Health Score (HJHS) were used to assess musculoskeletal functions...
2017: American Journal of Blood Research
https://www.readbyqxmd.com/read/29169581/vitamin-d-status-is-associated-with-executive-function-a-decade-later-data-from-the-women-s-healthy-ageing-project
#12
Alicia M Goodwill, Stephen Campbell, Steven Simpson, Maria Bisignano, Cherie Chiang, Lorraine Dennerstein, Cassandra Szoeke
OBJECTIVES: Vitamin D deficiency has been associated with cognitive decline and dementia in older adults. However, there is a paucity of studies assessing whether this association manifests from midlife. Given the long prodromal stage of dementia, we investigated the association between midlife vitamin D and cognition 10 years later. STUDY DESIGN: 252 participants (aged 55-67 years) from the Women's Healthy Ageing Project had baseline (2002) vitamin D and neuropsychological measures assessed...
January 2018: Maturitas
https://www.readbyqxmd.com/read/29168737/prevalence-and-predictors-of-subclinical-micronutrient-deficiency-in-german-older-adults-results-from-the-population-based-kora-age-study
#13
Romy Conzade, Wolfgang Koenig, Margit Heier, Andrea Schneider, Eva Grill, Annette Peters, Barbara Thorand
Subclinical micronutrient deficiency in older adults is associated with chronic age-related diseases and adverse functional outcomes. In Germany, the older population is at risk of insufficient micronutrient intake, but representative studies on micronutrient status in old and very old adults are scarce. This study's objectives were to estimate the prevalence of subclinical vitamin D, folate, vitamin B12 and iron deficiencies among older adults, aged 65 to 93, from the KORA-Age study in Augsburg, Germany (n = 1079), and to examine associated predictors, using multiple logistic regression...
November 23, 2017: Nutrients
https://www.readbyqxmd.com/read/29155243/the-24-25-to-25-hydroxyvitamin-d-ratio-and-fracture-risk-in-older-adults-the-cardiovascular-health-study
#14
Charles Ginsberg, Ronit Katz, Ian H de Boer, Bryan R Kestenbaum, Michel Chonchol, Michael G Shlipak, Mark J Sarnak, Andrew N Hoofnagle, Dena E Rifkin, Pranav S Garimella, Joachim H Ix
25-hydroxyvitamin D [25(OH)D] may not optimally indicate vitamin D receptor activity. Higher concentrations of its catabolic product 24,25-dihydroxyvitmin D [24,25(OH)2D] and a higher ratio of 24,25(OH)2D to 25(OH)D (the vitamin D metabolite ratio [VMR]) may provide additional information on receptor activity. We compared the strength of associations of these markers with serum PTH concentrations, hip bone mineral density (BMD), and risk of incident hip fracture in community-living older participants in the Cardiovascular Health Study...
November 16, 2017: Bone
https://www.readbyqxmd.com/read/29150169/vitamin-d-and-walking-speed-in-older-adults-systematic-review-and-meta-analysis
#15
REVIEW
Cedric Annweiler, Samir Henni, Stéphane Walrand, Manuel Montero-Odasso, Gustavo Duque, Guillaume T Duval
Vitamin D is involved in musculoskeletal health. There is no consensus on a possible association between circulating 25-hydroxyvitamin D (25OHD) concentrations and walking speed, a 'vital sign' in older adults. Our objective was to systematically review and quantitatively assess the association of 25OHD concentration with walking speed. A Medline search was conducted on June 2017, with no limit of date, using the MeSH terms "Vitamin D" OR "Vitamin D Deficiency" combined with "Gait" OR "Gait disorders, Neurologic" OR "Walking speed" OR "Gait velocity"...
December 2017: Maturitas
https://www.readbyqxmd.com/read/29142377/serum-vitamin-d-status-and-outcome-in-critically-ill-children
#16
Nazik Aşılıoğlu, Halit Çiǧdem, Muhammed Sükrü Paksu
Background: Vitamin D is a pleiotropic hormone essential for optimal health. Critical illness in children is a major cause of significant health-care utilization and mortality around the world. The association of Vitamin D deficiency (VDD) in critically ill adults has been well-studied, in comparison, the importance of Vitamin D in pediatric critical illness has been much less studied. Aim and Objectives: This study aimed to assess Vitamin D status and its determinants in patients admitted to a pediatric intensive care unit (PICU) in North of Turkey...
October 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29116541/a-cross-sectional-study-of-vitamin-d-levels-in-a-large-cohort-of-patients-with-rheumatic-diseases
#17
Elena Nikiphorou, Jaakko Uksila, Tuulikki Sokka
The objective of this study is to examine 25-hydroxyvitamin D [25(OH)D] (D-25) levels and associations with patient- and disease-related factors in rheumatic diseases. This is a register-based study of D-25 levels in adult patients seen at the Central Finland Hospital rheumatology clinic (January 2011-April 2015). Demographic, clinical, laboratory, and patient-reported outcomes (PROs) were collected as part of the normal infrastructure of the outpatient clinic and examined for their association with D-25 level...
November 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29114830/comparisons-of-interventions-for-preventing-falls-in-older-adults-a-systematic-review-and-meta-analysis
#18
Andrea C Tricco, Sonia M Thomas, Areti Angeliki Veroniki, Jemila S Hamid, Elise Cogo, Lisa Strifler, Paul A Khan, Reid Robson, Kathryn M Sibley, Heather MacDonald, John J Riva, Kednapa Thavorn, Charlotte Wilson, Jayna Holroyd-Leduc, Gillian D Kerr, Fabio Feldman, Sumit R Majumdar, Susan B Jaglal, Wing Hui, Sharon E Straus
Importance: Falls result in substantial burden for patients and health care systems, and given the aging of the population worldwide, the incidence of falls continues to rise. Objective: To assess the potential effectiveness of interventions for preventing falls. Data Sources: MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Ageline databases from inception until April 2017. Reference lists of included studies were scanned...
November 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29109736/identification-of-neuroprotective-factors-associated-with-successful-ageing-and-risk-of-cognitive-impairment-among-malaysia-older-adults
#19
Huijin Lau, Arimi Fitri Mat Ludin, Nor Fadilah Rajab, Suzana Shahar
The increase of ageing population has raised public attention on the concept of successful ageing. Studies have shown that vitamin D, telomere length, and brain-derived neurotrophic factor (BDNF) have been associated with cognitive function. Therefore, this study aimed to identify neuroprotective factors for cognitive decline in different ageing groups. A total of 300 older adults aged 60 years and above were recruited in this population based cross-sectional study. Participants were categorized into three groups: mild cognitive impairment (MCI) (n = 100), usual ageing (UA) (n = 100), and successful ageing (SA) (n = 100)...
2017: Current Gerontology and Geriatrics Research
https://www.readbyqxmd.com/read/29104377/seasonal-variation-in-vitamin-d-in-association-with-age-inflammatory-cytokines-anthropometric-parameters-and-lifestyle-factors-in-older-adults
#20
Leticia Elizondo-Montemayor, Elena C Castillo, Carlos Rodríguez-López, José R Villarreal-Calderón, Merit Gómez-Carmona, Sofia Tenorio-Martínez, Bianca Nieblas, Gerardo García-Rivas
Vitamin D deficiency is present even in sunny regions. Ageing decreases pre-vitamin D production in the skin and is associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, and inflammatory markers according to seasonal variation in Mexican healthy older adults. The same cohort was followed during 12 months. Vitamin D deficiency/insufficiency was found in 91.3% of the subjects despite living in appropriate latitude (25°40'0″N). 25(OH)D levels remained below <30 ng/mL through all seasons...
2017: Mediators of Inflammation
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