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Vitamin D older adults

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https://www.readbyqxmd.com/read/28522216/associations-of-lower-vitamin-d-concentrations-with-cognitive-decline-and-long-term-risk-of-dementia-and-alzheimer-s-disease-in-older-adults
#1
Catherine Feart, Catherine Helmer, Bénédicte Merle, François R Herrmann, Cédric Annweiler, Jean-François Dartigues, Cécile Delcourt, Cécilia Samieri
INTRODUCTION: Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent. METHODS: The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years. RESULTS: In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline...
May 9, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28505973/vitamin-d-insufficiency-and-cognitive-function-trajectories-in-older-adults-the-rancho-bernardo-study
#2
Gail A Laughlin, Donna Kritz-Silverstein, Jaclyn Bergstrom, Emilie T Reas, Simerjot K Jassal, Elizabeth Barrett-Connor, Linda K McEvoy
BACKGROUND: Evidence of a role for vitamin D (VitD) in cognitive aging is mixed and based primarily on extreme VitD deficiency. We evaluated the association of VitD insufficiency with cognitive function in older, community-dwelling adults living in a temperate climate with year-round sunshine. METHODS: A population-based longitudinal study of 1,058 adults (median age 75; 62% women) who had cognitive function assessed and serum levels of 25-hydroxyvitaminD (25OHD) measured in 1997-99 and were followed for up to three additional cognitive function assessments over a 12-year period...
May 11, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28488684/the-impact-of-cholecalciferol-supplementation-on-the-systemic-inflammatory-profile-a-systematic-review-and-meta-analysis-of-high-quality-randomized-controlled-trials
#3
REVIEW
E K Calton, K N Keane, P Newsholme, Y Zhao, M J Soares
Causal links between vitamin D status [25(OH)D] and systemic inflammation were examined through a systematic review of randomized controlled trials (RCTs). Selected RCTs were ⩾12 weeks, conducted in adults free of acute inflammatory disease, and of high-quality (Jadad score ⩾3). Of 14 studies that met our criteria, 9 studies (15 study arms) permitted extraction of data. There was no effect on the weighted mean difference (WMD) of IL-6 (WMD (95% confidence interval)=0.1, (-0.166, 0.366) pg/ml, P=0.462) or C-reactive protein (CRP) (WMD=-0...
May 10, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28486836/inverse-relationship-between-vitamin-d-levels-and-platelet-indices-in-korean-adults
#4
Yon Chul Park, Jin Kim, Min Seok Seo, Sung Won Hong, Eun Seok Cho, Jong-Koo Kim
BACKGROUND AND AIMS: Vitamin D deficiency and increased platelet indices are associated with increased rate or risk of several diseases such as cardiovascular disease and metabolic syndrome, respectively. We investigated whether vitamin D deficiency is associated with increased platelet count (PC) and mean platelet volume (MPV). METHODS AND RESULTS: The study included 3190 subjects older than 20 years. Subjects were divided into three groups based on their vitamin D levels: vitamin D deficiency (<10...
May 10, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28483427/association-between-muscle-function-and-body-composition-vitamin-d-status-and-blood-glucose-in-postmenopausal-women-with-type-2-diabetes
#5
Claudio M Bentes, Pablo B Costa, Monique Resende, Humberto L Miranda, Carolina M V Silva, Claudia C Netto, Lizanka P F Marinheiro
AIMS: The aim of this study was to examine the association between muscle function, and body composition, vitamin D status, and blood glucose in post-menopausal women with type 2 diabetes (T2D). METHODS: Forty post-menopausal women (62.48±7.67years; 154.6±5.11cm; 73.93±15.43kg; 31.13±5.82 BMI kg/m(2)) with a diagnosis of T2D participated in this cross-sectional study. The patients performed fasting blood sample exams, anthropometrics assessments, body composition, and clinical exams...
April 28, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28482093/can-nutrition-or-inflammation-moderate-the-age-cognition-association-among-older-adults
#6
Elizabeth P Handing, Brent J Small, Ross Andel, Cathy L McEvoy, Nagi Kumar
Objectives: Previous research has shown that nutrition can influence cognitive abilities in older adults. We examined whether nutritional factors or inflammatory biomarkers moderate the age-cognition association. Method: Analyses included 1,308 participants (age ≥60) from the National Health and Nutrition Examination Survey III. Macronutrients (% of calories from fat, protein, and carbohydrates), micronutrients/amino acids (blood serum values: Vitamins B12, C, D, E, folate, iron, homocysteine, and β-carotene), and inflammatory biomarkers (serum C-reactive protein, plasma fibrinogen, and serum ferritin) were examined as moderators with cognition...
May 6, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28475987/attenuated-pth-responsiveness-to-vitamin-d-deficiency-among-patients-with-type-2-diabetes-and-chronic-hyperglycemia
#7
Ahmed F Al-Jebawi, Ahmed H YoussefAgha, Hanan Sulaiman Al Suwaidi, Moza Saif Albadwawi, Asma Shabib Al Marzooqi, Ashjan Hassan Banihammad, Samia Hussain Almarzooqi, Mouza Khalifa Alkaabi
BACKGROUND: The short and long-term relationship between hyperglycemia and PTH level among patients suffering from both diabetes type 2 and vitamin D deficiency were evaluated. METHODS: This was a cross sectional study performed at Dubai Diabetes Center, UAE. To demonstrate the relationship between hyperglycemia and PTH level, subjects with type 2 diabetes and vitamin D deficiency (124 adults) were divided into 4 groups based on their FPG and HbA1c levels. RESULTS: Mean vitamin D and PTH levels among subjects with HbA1c≤7% (53mmol/mol) were 14...
April 19, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28460586/supplementation-with-6s-5-methyltetrahydrofolate-or-folic-acid-equally-reduces-serum-homocysteine-concentrations-in-older-adults
#8
Ewa Sicińska, Anna Brzozowska, Wojciech Roszkowski, Paul M Finglas
Folic acid (FA) supplementation reduces the elevated serum homocysteine (Hcy) concentrations. [6 S]-5-methyltetrahydrofolate ([6 S]-5-MTHF) is an alternative to FA due to possible advantages, that is, no masking cobalamin deficiency. The study aim was to evaluate the effectiveness of [6 S]-5-MTHF in relations to FA supplementation in reducing the serum Hcy. Healthy volunteers, aged 50-65, had normal serum folate and did not use supplements with B-vitamins for 6 months. Forty subjects were divided into two groups: receiving 400 μg/d FA or the equimolar amount of [6 S]-5-MTHF...
May 2, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28452813/duodenal-histopathology-and-laboratory-deficiencies-related-to-bone-metabolism-in-coeliac-disease
#9
Lotte Posthumus, Abdul Al-Toma
OBJECTIVES: Coeliac disease (CD) is a chronic immune-mediated small intestine enteropathy precipitated by gluten in genetically predisposed individuals. Adult presentation is often atypical and malabsorption of vitamins and minerals is common, with a consequent disturbance of bone metabolism. We aim to evaluate laboratory deficiencies related to bone metabolism and the relationship between severity of histological damage and degree of bone mass loss at diagnosis of CD. MATERIALS AND METHODS: A retrospective cross-sectional study of 176 adult coeliac patients was carried out...
April 27, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28433267/dose-response-effects-of-supplementation-with-calcifediol-on-serum-25-hydroxyvitamin-d-status-and-its-metabolites-a-randomized-controlled-trial-in-older-adults
#10
Anouk M M Vaes, Michael Tieland, Margot F de Regt, Jonas Wittwer, Luc J C van Loon, Lisette C P G M de Groot
BACKGROUND & AIMS: Oral supplementation with vitamin D is recommended for older adults to maintain a sufficient 25-hydroxyvitamin D (25(OH)D) status throughout the year. While supplementation with vitamin D2 or D3 is most common, alternative treatment regimens exist which require further investigation with respect to increasing 25(OH)D concentration. We investigated the dose-response effects of supplementation with calcifediol compared to vitamin D3 and assessed the dose which results in mean serum 25(OH)D3 concentrations between 75 and 100 nmol/L...
March 31, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28390950/reduced-ability-of-calcitriol-to-promote-augmented-dopamine-release-in-the-lesioned-striatum-of-aged-rats
#11
Wayne A Cass, Laura E Peters
Parkinson's disease (PD) is a progressive and debilitating neurodegenerative disorder that affects over one million people in the United States. Previous studies, carried out in young adult rats, have shown that calcitriol, the active metabolite of vitamin D, can be neuroprotective in 6-hydroxydopamine (6-OHDA) models of PD. However, as PD usually affects older individuals, the ability of calcitriol to promote dopaminergic recovery was examined in lesioned young adult (4 month old), middle-aged (14 month old) and aged (22 month old) rats...
April 5, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28384340/parathyroid-hormone-and-vitamin-d-are-associated-with-the-risk-of-metabolic-obesity-in-a-middle-aged-and-older-korean-population-with-preserved-renal-function-a-cross-sectional-study
#12
Jeonghoon Ha, Kwanhoon Jo, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo I L Kang, Bong Yun Cha, Min-Hee Kim
BACKGROUND: In general, obesity is a major contributor to metabolic syndrome (MetS) and is associated with insulin resistance (IR). Metabolically obese but normal weight (MONW) individuals present metabolic abnormalities and features of MetS despite having a normal range of body mass index (BMI). In recent years, different subtypes of obesity have been introduced, including metabolically healthy obese (MHO) and metabolically obese obese (MOO). Also, it has been reported that vitamin D and parathyroid hormone (PTH) are possibly linked with MetS...
2017: PloS One
https://www.readbyqxmd.com/read/28382112/the-role-of-vitamin-d-in-maintaining-bone-health-in-older-people
#13
REVIEW
Thomas R Hill, Terry J Aspray
This review summarises aspects of vitamin D metabolism, the consequences of vitamin D deficiency, and the impact of vitamin D supplementation on musculoskeletal health in older age. With age, changes in vitamin D exposure, cutaneous vitamin D synthesis and behavioural factors (including physical activity, diet and sun exposure) are compounded by changes in calcium and vitamin D pathophysiology with altered calcium absorption, decreased 25-OH vitamin D [25(OH)D] hydroxylation, lower renal fractional calcium reabsorption and a rise in parathyroid hormone...
April 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28369286/a-2-year-follow-up-after-a-2-year-rct-with-vitamin-d-and-exercise-effects-on-falls-injurious-falls-and-physical-functioning-among-older-women
#14
Kirsti Uusi-Rasi, Radhika Patil, Saija Karinkanta, Pekka Kannus, Kari Tokola, Christel Lamberg-Allardt, Harri Sievänen
Background: Both exercise and vitamin D are recommended means to prevent falls among older adults, but their combined effects on fall-induced injuries are scarcely studied. Methods: A 2-year follow-up of a previous 2-year randomized controlled trial with vitamin D and exercise (Ex) of 409 older home-dwelling women using a factorial 2 × 2 design (D-Ex-, D+Ex-, D-Ex+, D+Ex+). Besides monthly fall diaries, femoral neck bone mineral density (fn-BMD), and physical functioning were assessed at 1 and 2 years after the intervention...
March 21, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28361806/association-between-serum-vitamin-d-and-metabolic-syndrome-in-middle-aged-and-older-adults-and-role-of-supplementation-therapy-with-vitamin-d
#15
Walter Verrusio, Paola Andreozzi, Alessia Renzi, Marco Musumeci, Nicolò Gueli, Mauro Cacciafesta
OBJECTIVES: To evaluate i) the correlation between vitamin D (vit. D) serum concentrations and metabolic syndrome (MetS); ii) the efficacy of 6 months supplementation therapy with vit. D. METHOD: 200 patients were enrolled. Blood analyses and anthropometric measurements were carried out. Patients with hypovitaminosis D received an oral supplement therapy. RESULTS: 81% of the sample shows vit. D levels < 30 ng/mL. Rate of MetS was significantly higher in vit...
January 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28359360/postprandial-changes-in-glucose-oxidation-and-insulin-sensitivity-in-metabolic-syndrome-influence-of-fibroblast-growth-factor-21-and-vitamin-d-status
#16
Kaveri Pathak, Mario J Soares, Yun Zhao, Anthony P James, Jillian L Sherriff, Philip Newsholme
OBJECTIVE: Metabolic inflexibility due to insulin resistance has been reported in metabolic syndrome (MetS). Fibroblast growth factor 21 (FGF21) and vitamin D status may improve insulin sensitivity. The aim of this study was to investigate glucose-induced thermogenesis and oxidation in MetS, and to examine whether changes in FGF21 or prevailing vitamin D status modulated defined metabolic parameters. METHODS: Forty-eight overweight and obese older adults (14 men, 34 women; ages 51 ± 15 y) were studied...
May 2017: Nutrition
https://www.readbyqxmd.com/read/28352281/vitamin-d-deficiency-and-its-determinants-in-adults-a-sample-from-community-based-settings-in-the-united-arab-emirates
#17
Wegdan Bani-Issa, Kamal Eldeirawi, Sondos Harfil, Randa Fakhry
Background. Vitamin D deficiency (VDD) is a public health concern in adults worldwide. This study aims to explore the extent of VDD and its associated factors among adults in the United Arab Emirates (UAE). Subjects and Methods. Quantitative, cross-sectional research was used to assess VDD and its associated factors in 216 adults recruited from randomly selected community-based healthcare settings over a six-month period. Recent values of vitamin D and glycated hemoglobin (HbA1c) were abstracted from medical records, followed by interviews with participants to obtain information on factors related to VDD and other covariates and to measure their heights and weights...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28341251/vitamin-d-and-muscle-function
#18
Bess Dawson-Hughes
Muscle weakness is a hallmark of severe vitamin D deficiency, but the effect of milder vitamin D deficiency or insufficiency on muscle mass and performance and risk of falling is uncertain. In this presentation, I review the evidence that vitamin D influences muscle mass and performance, balance, and risk of falling in older adults. Special consideration is given to the impact of both the starting 25-hydroxyvitamin D [25(OH)D] level and the dose administered on the clinical response to supplemental vitamin D in older men and women...
March 21, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28339536/successful-nutrition-policy-improvement-of-vitamin-d-intake-and-status-in-finnish-adults-over-the-last-decade
#19
Susanna Raulio, Iris Erlund, Satu Männistö, Sirpa Sarlio-Lähteenkorva, Jouko Sundvall, Heli Tapanainen, Erkki Vartiainen, Suvi M Virtanen
Due to vitamin D intake below recommendation (10 µg/day) and low (<50 nmol/l) serum 25-hydroxycholecalciferol (25(OH)D) concentration in Finnish population, the fortification of liquid dairy products with 0.5 µg vitamin D/100 g and fat spreads with 10 µg/100 g started in Finland in December 2002. In 2010, the fortification recommendation was doubled. The aim of this study was to investigate whether the vitamin D intake and status have improved among Finnish adults as a consequence of these nutrition policy actions...
October 6, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/28336104/serum-25-hydroxyvitamin-d-and-metabolic-syndrome-in-a-japanese-working-population-the-furukawa-nutrition-and-health-study
#20
Shamima Akter, Masafumi Eguchi, Kayo Kurotani, Takeshi Kochi, Ikuko Kashino, Rie Ito, Keisuke Kuwahara, Hiroko Tsuruoka, Isamu Kabe, Tetsuya Mizoue
OBJECTIVE: Increasing evidence has suggested a protective role of vitamin D on metabolic syndrome (MetS). However, studies addressing this issue are limited in Asia and it remains unclear whether calcium could modify the association. We examined the association of serum 25-hydroxyvitamin D (25(OH)D) status with MetS, and the potential effect modification by calcium intake in a Japanese working population. METHODS: Study subjects were 1790 workers, ages 18 to 69 y, who participated in a health survey at the time of periodic checkup...
April 2017: Nutrition
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