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Vitamin D older adults

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https://www.readbyqxmd.com/read/28433267/dose-response-effects-of-supplementation-with-calcifediol-on-serum-25-hydroxyvitamin-d-status-and-its-metabolites-a-randomized-controlled-trial-in-older-adults
#1
Anouk M M Vaes, Michael Tieland, Margot F de Regt, Jonas Wittwer, Luc J C van Loon, Lisette C P G M de Groot
BACKGROUND & AIMS: Oral supplementation with vitamin D is recommended for older adults to maintain a sufficient 25-hydroxyvitamin D (25(OH)D) status throughout the year. While supplementation with vitamin D2 or D3 is most common, alternative treatment regimens exist which require further investigation with respect to increasing 25(OH)D concentration. We investigated the dose-response effects of supplementation with calcifediol compared to vitamin D3 and assessed the dose which results in mean serum 25(OH)D3 concentrations between 75 and 100 nmol/L...
March 31, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28390950/reduced-ability-of-calcitriol-to-promote-augmented-dopamine-release-in-the-lesioned-striatum-of-aged-rats
#2
Wayne A Cass, Laura E Peters
Parkinson's disease (PD) is a progressive and debilitating neurodegenerative disorder that affects over one million people in the United States. Previous studies, carried out in young adult rats, have shown that calcitriol, the active metabolite of vitamin D, can be neuroprotective in 6-hydroxydopamine (6-OHDA) models of PD. However, as PD usually affects older individuals, the ability of calcitriol to promote dopaminergic recovery was examined in lesioned young adult (4 month old), middle-aged (14 month old) and aged (22 month old) rats...
April 5, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28384340/parathyroid-hormone-and-vitamin-d-are-associated-with-the-risk-of-metabolic-obesity-in-a-middle-aged-and-older-korean-population-with-preserved-renal-function-a-cross-sectional-study
#3
Jeonghoon Ha, Kwanhoon Jo, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo I L Kang, Bong Yun Cha, Min-Hee Kim
BACKGROUND: In general, obesity is a major contributor to metabolic syndrome (MetS) and is associated with insulin resistance (IR). Metabolically obese but normal weight (MONW) individuals present metabolic abnormalities and features of MetS despite having a normal range of body mass index (BMI). In recent years, different subtypes of obesity have been introduced, including metabolically healthy obese (MHO) and metabolically obese obese (MOO). Also, it has been reported that vitamin D and parathyroid hormone (PTH) are possibly linked with MetS...
2017: PloS One
https://www.readbyqxmd.com/read/28382112/the-role-of-vitamin-d-in-maintaining-bone-health-in-older-people
#4
REVIEW
Thomas R Hill, Terry J Aspray
This review summarises aspects of vitamin D metabolism, the consequences of vitamin D deficiency, and the impact of vitamin D supplementation on musculoskeletal health in older age. With age, changes in vitamin D exposure, cutaneous vitamin D synthesis and behavioural factors (including physical activity, diet and sun exposure) are compounded by changes in calcium and vitamin D pathophysiology with altered calcium absorption, decreased 25-OH vitamin D [25(OH)D] hydroxylation, lower renal fractional calcium reabsorption and a rise in parathyroid hormone...
April 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28369286/a-2-year-follow-up-after-a-2-year-rct-with-vitamin-d-and-exercise-effects-on-falls-injurious-falls-and-physical-functioning-among-older-women
#5
Kirsti Uusi-Rasi, Radhika Patil, Saija Karinkanta, Pekka Kannus, Kari Tokola, Christel Lamberg-Allardt, Harri Sievänen
Background: Both exercise and vitamin D are recommended means to prevent falls among older adults, but their combined effects on fall-induced injuries are scarcely studied. Methods: A 2-year follow-up of a previous 2-year randomized controlled trial with vitamin D and exercise (Ex) of 409 older home-dwelling women using a factorial 2 × 2 design (D-Ex-, D+Ex-, D-Ex+, D+Ex+). Besides monthly fall diaries, femoral neck bone mineral density (fn-BMD), and physical functioning were assessed at 1 and 2 years after the intervention...
March 21, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28361806/association-between-serum-vitamin-d-and-metabolic-syndrome-in-middle-aged-and-older-adults-and-role-of-supplementation-therapy-with-vitamin-d
#6
Walter Verrusio, Paola Andreozzi, Alessia Renzi, Marco Musumeci, Nicolò Gueli, Mauro Cacciafesta
OBJECTIVES: To evaluate i) the correlation between vitamin D (vit. D) serum concentrations and metabolic syndrome (MetS); ii) the efficacy of 6 months supplementation therapy with vit. D. METHOD: 200 patients were enrolled. Blood analyses and anthropometric measurements were carried out. Patients with hypovitaminosis D received an oral supplement therapy. RESULTS: 81% of the sample shows vit. D levels < 30 ng/mL. Rate of MetS was significantly higher in vit...
January 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28359360/postprandial-changes-in-glucose-oxidation-and-insulin-sensitivity-in-metabolic-syndrome-influence-of-fibroblast-growth-factor-21-and-vitamin-d-status
#7
Kaveri Pathak, Mario J Soares, Yun Zhao, Anthony P James, Jillian L Sherriff, Philip Newsholme
OBJECTIVE: Metabolic inflexibility due to insulin resistance has been reported in metabolic syndrome (MetS). Fibroblast growth factor 21 (FGF21) and vitamin D status may improve insulin sensitivity. The aim of this study was to investigate glucose-induced thermogenesis and oxidation in MetS, and to examine whether changes in FGF21 or prevailing vitamin D status modulated defined metabolic parameters. METHODS: Forty-eight overweight and obese older adults (14 men, 34 women; ages 51 ± 15 y) were studied...
May 2017: Nutrition
https://www.readbyqxmd.com/read/28352281/vitamin-d-deficiency-and-its-determinants-in-adults-a-sample-from-community-based-settings-in-the-united-arab-emirates
#8
Wegdan Bani-Issa, Kamal Eldeirawi, Sondos Harfil, Randa Fakhry
Background. Vitamin D deficiency (VDD) is a public health concern in adults worldwide. This study aims to explore the extent of VDD and its associated factors among adults in the United Arab Emirates (UAE). Subjects and Methods. Quantitative, cross-sectional research was used to assess VDD and its associated factors in 216 adults recruited from randomly selected community-based healthcare settings over a six-month period. Recent values of vitamin D and glycated hemoglobin (HbA1c) were abstracted from medical records, followed by interviews with participants to obtain information on factors related to VDD and other covariates and to measure their heights and weights...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28341251/vitamin-d-and-muscle-function
#9
Bess Dawson-Hughes
Muscle weakness is a hallmark of severe vitamin D deficiency, but the effect of milder vitamin D deficiency or insufficiency on muscle mass and performance and risk of falling is uncertain. In this presentation, I review the evidence that vitamin D influences muscle mass and performance, balance, and risk of falling in older adults. Special consideration is given to the impact of both the starting 25-hydroxyvitamin D [25(OH)D] level and the dose administered on the clinical response to supplemental vitamin D in older men and women...
March 21, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28339536/successful-nutrition-policy-improvement-of-vitamin-d-intake-and-status-in-finnish-adults-over-the-last-decade
#10
Susanna Raulio, Iris Erlund, Satu Männistö, Sirpa Sarlio-Lähteenkorva, Jouko Sundvall, Heli Tapanainen, Erkki Vartiainen, Suvi M Virtanen
Due to vitamin D intake below recommendation (10 µg/day) and low (<50 nmol/l) serum 25-hydroxycholecalciferol (25(OH)D) concentration in Finnish population, the fortification of liquid dairy products with 0.5 µg vitamin D/100 g and fat spreads with 10 µg/100 g started in Finland in December 2002. In 2010, the fortification recommendation was doubled. The aim of this study was to investigate whether the vitamin D intake and status have improved among Finnish adults as a consequence of these nutrition policy actions...
October 6, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/28336104/serum-25-hydroxyvitamin-d-and-metabolic-syndrome-in-a-japanese-working-population-the-furukawa-nutrition-and-health-study
#11
Shamima Akter, Masafumi Eguchi, Kayo Kurotani, Takeshi Kochi, Ikuko Kashino, Rie Ito, Keisuke Kuwahara, Hiroko Tsuruoka, Isamu Kabe, Tetsuya Mizoue
OBJECTIVE: Increasing evidence has suggested a protective role of vitamin D on metabolic syndrome (MetS). However, studies addressing this issue are limited in Asia and it remains unclear whether calcium could modify the association. We examined the association of serum 25-hydroxyvitamin D (25(OH)D) status with MetS, and the potential effect modification by calcium intake in a Japanese working population. METHODS: Study subjects were 1790 workers, ages 18 to 69 y, who participated in a health survey at the time of periodic checkup...
April 2017: Nutrition
https://www.readbyqxmd.com/read/28329121/very-low-calorie-diets-for-weight-loss-in-obese-older-adults-a-randomized-trial
#12
Cilla J Haywood, Luke A Prendergast, Katrina Purcell, Lauren Le Fevre, Wen Kwang Lim, Mary Galea, Joseph Proietto
Background: Obesity contributes to disability in older adults, and this is offset by weight loss and exercise. Very Low Calorie Diets (VLCDs) achieve rapid weight loss; however, these have not been rigorously evaluated in older people. Methods: A randomized trial was conducted from August 2012 through December 2015. The intervention was 12 weeks of thrice weekly exercise combined with either healthy eating advice (Ex/HE), hypocaloric diet (Ex/Diet), or VLCD (Ex/VLCD)...
February 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28322879/the-association-between-beliefs-about-vitamin-d-and-skin-cancer-risk-related-behaviors
#13
Dawn M Holman, Zahava Berkowitz, Gery P Guy, Natasha Buchanan Lunsford, Elliot J Coups
Major health organizations recommend obtaining most of one's vitamin D through dietary sources rather than from sun exposure, given the link between sun exposure and increased skin cancer risk. The purpose of this study is to examine the association between beliefs about vitamin D and skin cancer risk-related behaviors, a topic on which research is limited. We analyzed cross-sectional online survey data collected in the summer of 2015 from 4127U.S. adults aged 18years and older. Overall, 19.7% of adults believed that sun protection would put them at risk of not getting enough vitamin D...
March 18, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28321507/the-relationship-between-cumulative-lifetime-ultraviolet-radiation-exposure-bone-mineral-density-falls-risk-and-fractures-in-older-adults
#14
M J W Thompson, D A Aitken, P Otahal, J Cicolini, T M Winzenberg, G Jones
Data linking cumulative lifetime vitamin D status with skeletal outcomes are lacking. We show that increasing cumulative sun exposure was associated with higher bone mineral density in younger males and protective against fractures in females independent of current vitamin D. This supports the concept that cumulative sun exposure is an important contributor to skeletal health. INTRODUCTION: While low 25-hydroxyvitamin D levels are associated with increased fracture risk, this reflects only recent sun exposure...
March 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28315661/nutrient-biomarker-patterns-and-long-term-risk-of-dementia-in-older-adults
#15
Camille Amadieu, Sophie Lefèvre-Arbogast, Cécile Delcourt, Jean-François Dartigues, Catherine Helmer, Catherine Féart, Cécilia Samieri
INTRODUCTION: Several nutrients may predict dementia risk. We characterized nutrient biomarker patterns, which integrate the complexity of nutrient exposure and biodisponibility associated with long-term risk of dementia in a large cohort of older persons, the Three-City study. METHODS: We included 666 nondemented participants with plasma measurements of 22 fat-soluble nutrients at baseline, who were followed up for 12 years for dementia. RESULTS: A "deleterious" pattern combining lower blood status in vitamin D, carotenoids, and polyunsaturated fats and higher saturated fats was strongly associated with a higher risk of dementia...
March 18, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28301451/traumatic-brain-injury-related-emergency-department-visits-hospitalizations-and-deaths-united-states-2007-and-2013
#16
Christopher A Taylor, Jeneita M Bell, Matthew J Breiding, Likang Xu
PROBLEM/CONDITION: Traumatic brain injury (TBI) has short- and long-term adverse clinical outcomes, including death and disability. TBI can be caused by a number of principal mechanisms, including motor-vehicle crashes, falls, and assaults. This report describes the estimated incidence of TBI-related emergency department (ED) visits, hospitalizations, and deaths during 2013 and makes comparisons to similar estimates from 2007. REPORTING PERIOD: 2007 and 2013. DESCRIPTION OF SYSTEM: State-based administrative health care data were used to calculate estimates of TBI-related ED visits and hospitalizations by principal mechanism of injury, age group, sex, and injury intent...
March 17, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28294172/effects-of-vitamin-c-supplementation-on-glycaemic-control-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#17
REVIEW
A W Ashor, A D Werner, J Lara, N D Willis, J C Mathers, M Siervo
Randomised controlled trials (RCTs) have observed contrasting results on the effects of vitamin C on circulating biomarkers of glycaemic and insulin regulation. We conducted a systematic review and meta-analysis of RCTs testing the effect of vitamin C administration on glucose, HbA1c and insulin concentrations. Four databases (PubMed, Embase, Scopus and Cochrane Library) were used to retrieve RCTs published from inception until April 2016 and testing the effects of vitamin C in adult participants. The screening of 2008 articles yielded 22 eligible studies (937 participants)...
March 15, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28289868/associations-of-vitamin-d-status-with-dietary-intakes-and-physical-activity-levels-among-adults-from-seven-european-countries-the-food4me-study
#18
Yannis Manios, George Moschonis, Christina P Lambrinou, Christina Mavrogianni, Lydia Tsirigoti, Ulrich Hoeller, Franz F Roos, Igor Bendik, Manfred Eggersdorfer, Carlos Celis-Morales, Katherine M Livingstone, Cyril F M Marsaux, Anna L Macready, Rosalind Fallaize, Clare B O'Donovan, Clara Woolhead, Hannah Forster, Marianne C Walsh, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Jacqueline Hallmann, Mirosław Jarosz, Agnieszka Surwiłło, Iwona Traczyk, Christian A Drevon, Ben van Ommen, Keith Grimaldi, John N S Matthews, Hannelore Daniel, J Alfredo Martinez, Julie A Lovegrove, Eileen R Gibney, Lorraine Brennan, Wim H M Saris, Mike Gibney, John C Mathers
PURPOSE: To report the vitamin D status in adults from seven European countries and to identify behavioural correlates. METHODS: In total, 1075 eligible adult men and women from Ireland, Netherlands, Spain, Greece, UK, Poland and Germany, were included in the study. RESULTS: Vitamin D deficiency and insufficiency, defined as 25-hydroxy vitamin D3 (25-OHD3) concentration of <30 and 30-49.9 nmol/L, respectively, were observed in 3.3 and 30...
March 13, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28267864/mitigating-nutrition-and-health-deficiencies-in-older-adults-a-role-for-food-innovation
#19
REVIEW
Sephora Baugreet, Ruth M Hamill, Joseph P Kerry, Sinéad N McCarthy
The aim of this review is to describe the factors contributing to diminished food intake, resulting in nutritional deficiencies and associated health conditions in older adults and proposes food innovation strategies to mitigate these. Research has provided convincing evidence of a link between healthy eating patterns and healthy aging. There is a need to target new food product development (NPD) with functional health benefits specifically designed to address the particular food-related needs of older consumers...
April 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28250192/dairy-intake-is-protective-against-bone-loss-in-older-vitamin-d-supplement-users-the-framingham-study
#20
Shivani Sahni, Kelsey M Mangano, Douglas P Kiel, Katherine L Tucker, Marian T Hannan
Background: Previous studies showed beneficial effects of specific dairy foods on bone health in middle-aged adults.Objective: We examined the association of milk, yogurt, cheese, cream, fluid dairy (milk + yogurt), and milk + yogurt + cheese intakes with bone mineral density (BMD) and 4-y percentage of change in BMD [▵%BMD; femoral neck, trochanter, and lumbar spine (LS)]. We further assessed whether these associations were modified by vitamin D supplement use in this cohort of older adults.Methods: Food-frequency questionnaire responses, baseline BMD (hip and spine, n = 862 in 1988-1989), and follow-up BMD (n = 628 in 1992-1993) were measured in the Framingham study, a prospective cohort study of older Caucasian men and women aged 67-93 y...
April 2017: Journal of Nutrition
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