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https://www.readbyqxmd.com/read/28817542/safety-of-transesophageal-echocardiography%C3%A2-guided-electrical-cardioversion-in-patients-with-atrial-fibrillation-and-inadequate-anticoagulation
#1
Joanna Zaprutko, Artur Baszko, Michał Michalak, Karol Kochman, Radosław Szymański, Jan Kłopocki, Anna Nowicka, Rafał Dankowski, Marek Michalski, Piotr Kałmucki, Andrzej Szyszka
INTRODUCTION    Restoring sinus rhythm in patients with atrial fibrillation (AF)/atrial flutter (AFl) requires adequate oral anticoagulation prior to direct current cardioversion (DCC). Some patients eligible for DCC are not properly anticoagulated. OBJECTIVES    The aim of the study was to assess risk factors for thrombus and spontaneous echo contrast (SEC) in the left atrium (LA) as well as the safety profile of transesophageal echocardiography (TEE)-guided DCC in patients with inadequate anticoagulation...
August 9, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28816921/validity-reliability-and-inertia-of-four-different-temperature-capsule-systems
#2
Coen C W G Bongers, Hein A M Daanen, Cornelis P Bogerd, Maria T E Hopman, Thijs M H Eijsvogels
PURPOSE: Telemetric temperature capsule systems are wireless, relatively non-invasive and easily applicable in field conditions, and have therefore great advantages for monitoring core body temperature. However, the accuracy and responsiveness of available capsule systems have not been compared previously. Therefore, the aim of this study was to examine the validity, reliability and inertia characteristics of four ingestible temperature capsule systems (i.e. CorTemp, e-Celsius, myTemp and VitalSense)...
August 14, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28816318/a-soluble-star-shaped-silsesquioxane-cored-polymer-towards-novel-stabilization-of-ph-dependent-high-internal-phase-emulsions
#3
Yuxiu Xing, Jun Peng, Kai Xu, Shuxi Gao, Xuefeng Gui, Shengyuan Liang, Longfeng Sun, Mingcai Chen
A well-defined pH-responsive star-shaped polymer containing poly(N,N-dimethylaminoethyl methacrylate) (PDMA) arms and a cage-like methacryloxypropyl silsesquioxane (CMSQ-T10) core was used as an interfacial stabilizer for emulsions consisting of m-xylene and water. We explored the properties of the CMSQ/PDMA star-shaped polymer using the characteristic results of nuclear magnetic resonance (NMR) spectroscopy, size exclusion chromatography (SEC), dynamic light scattering (DLS), and zeta potential and conductivity measurements...
August 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28814470/a-dangerous-context-changes-the-way-that-rats-learn-about-and-discriminate-between-innocuous-events-in-sensory-preconditioning
#4
Nathan M Holmes, R Frederick Westbrook
Four experiments used a sensory preconditioning protocol to examine how a dangerous context influences learning about innocuous events. In Experiments 1, 2, and 3, rats were exposed to presentations of a tone followed immediately or 20-sec later by presentations of a light. These tone-light pairings occurred in a context that was either familiar and safe, or equally familiar but dangerous, that is, it was a context in which rats had been exposed to footshock. Rats were next exposed to parings of the light and shock and then tested with the tone (and light)...
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28813914/data-sample-size-needed-for-analysis-of-kinematic-and-muscle-synergies-in-healthy-and-stroke-populations
#5
Navid Lambert-Shirzad, H F Machiel Van der Loos
Multiple studies have suggested the central nervous system (CNS) generates motions by using modular control of muscles and joints (synergies). However, the synergies reported by these studies are task dependent and might not reflect the true control strategies adopted by the CNS. Studying exploratory motions (EMs) can reveal biomechanical constraints and motor control strategies in healthy and clinical populations. The first logical step to consider EMs in study of motor synergies is to determine how much data is required to reliably and fully profile the motion patterns of an individual...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28810785/explicitly-correlated-n-electron-valence-state-perturbation-theory-nevpt2-f12
#6
Yang Guo, Kantharuban Sivalingam, Edward F Valeev, Frank Neese
In this work, explicitly correlated second order N-electron valence state perturbation theory (NEVPT2-F12) has been derived and implemented for the first time. The NEVPT2-F12 algorithm presented here is based on a fully internally contracted wave function and includes the correction of semi-internal excitation subspaces. The algorithm exploits the resolution of identity (RI) approximation to improve the computational efficiency. The overall O(N(5)) scaling of the computational effort is documented. In Sec. III, the dissociation processes of diatomic molecules and the singlet-triplet gap of several systems are studied...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810625/inhaled-corticosteroids-improve-lung-function-airway-hyper-responsiveness-and-airway-inflammation-but-not-symptom-control-in-patients-with-mild-intermittent-asthma-a-meta-analysis
#7
Wei Du, Ling Zhou, Yingmeng Ni, Yuanyuan Yu, Fang Wu, Guochao Shi
It remains controversial whether inhaled corticosteroid (ICS) should be used in patients with intermittent asthma. The present study aimed to assess the effect of ICS compared with placebo or other therapies in patients with intermittent asthma. Medline, Embase and CNKI databases were searched up to June 2016 and a meta-analysis was conducted. The findings demonstrated that in adult patients, when compared with placebo, ICS increased forced expiratory volume in 1 sec FEV1 [standardized mean difference (SMD), 0...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809724/comparison-of-hemostasis-times-with-a-kaolin-based-hemostatic-pad-quikclot-radial-vs-mechanical-compression-tr-band-following-transradial-access-a-pilot-prospective-study
#8
Jonathan S Roberts, Jianli Niu, Juan A Pastor-Cervantes
BACKGROUND: Hemostasis following transradial access (TRA) is usually achieved by mechanical compression. We investigated use of the QuikClot Radial hemostasis pad (Z-Medica) compared with the TR Band (Terumo Medical) to shorten hemostasis after TRA. METHODS: Thirty patients undergoing TRA coronary angiography and/or percutaneous coronary intervention were randomized into three cohorts post TRA: 10 patients received mechanical compression with the TR Band, 10 patients received 30 min of compression with the QuikClot Radial pad, and 10 patients received 60 min of compression with the QuikClot Radial pad...
August 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28808125/insights-into-substrate-promiscuity-of-human-seryl-trna-synthetase
#9
Kaitlyn M Holman, Anupama K Puppala, Jonathan W Lee, Hyun Lee, Miljan Simonovic
Seryl-tRNA synthetase (SerRS) attaches L-serine to the cognate serine tRNA (tRNA(Ser)) and the non-cognate selenocysteine tRNA (tRNA(Sec)). The latter activity initiates the anabolic cycle of selenocysteine (Sec), proper decoding of an in-frame Sec UGA codon, and synthesis of selenoproteins across all domains of life. While the accuracy of SerRS is important for overall proteome integrity, it is its substrate promiscuity that is vital for the integrity of the selenoproteome. This raises a question as to what elements in the two tRNA species, harboring different anticodon sequences and adopting distinct folds, facilitate aminoacylation by a common aminoacyl-tRNA synthetase...
August 14, 2017: RNA
https://www.readbyqxmd.com/read/28808000/vibrio-cholerae-type-6-secretion-system-effector-trafficking-in-target-bacterial-cells
#10
Brian T Ho, Yang Fu, Tao G Dong, John J Mekalanos
The type 6 secretion system (T6SS) is used by many Gram-negative bacterial species to deliver toxic effector proteins into nearby bacteria prey cells to kill or inhibit their growth. VgrG proteins are core conserved secretion substrates of the T6SS and one subset of T6SS effectors consists of VgrG proteins with C-terminal extension domains carrying various enzymatic activities. In Vibrio cholerae, VgrG3 has a hydrolase extension domain and degrades peptidoglycan in the periplasm of target bacteria. In this study, we replaced this domain with a nuclease domain from Salmonella enterica subsp...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807991/torque-depression-following-active-shortening-is-associated-with-a-modulation-of-cortical-and-spinal-excitation-a-history-dependent-study
#11
Jordan Grant, Chris J McNeil, Leah R Bent, Geoffrey A Power
The reduction in steady-state isometric torque following a shortening muscle action when compared to a purely isometric contraction at the same muscle length and level of activation is termed torque depression (TD). The purpose of this study was to investigate spinal and supraspinal neural responses during the TD state of a maximal voluntary activation of the ankle dorsiflexors. Thirteen subjects (10 male) were recruited for the study. To explore alterations in corticospinal excitability during voluntary muscle activation in the TD state, motor evoked potentials (MEPs), cervicomedullary motor evoked potentials (CMEPs), and maximal compound muscle action potentials (Mmax) were elicited during the isometric steady-state following active shortening (i...
August 2017: Physiological Reports
https://www.readbyqxmd.com/read/28806571/separation-and-characterization-of-allergic-polymerized-impurities-in-cephalosporins-by-2d-hpsec%C3%A3-lc-it-tof-ms
#12
Yu Xu, DanDan Wang, Lan Tang, Jian Wang
Eleven unknown allergic impurities in cefodizime, cefmenoxime and cefonicid were separated and characterized by a trap-free two-dimensional high performance size exclusion chromatography (HPSEC) and reversed phase liquid chromatography (RP-HPLC) coupled to high resolution ion trap/time-of-flight mass spectrometry (2D-HPSEC×LC-IT-TOF MS) with positive and negative modes of electrospray ionization method. Separation and characterization the allergic polymerized impurities in β-lactam antibiotics were on the basis of column-switching technique which effectively combined the advantages of HPSEC and the ability of RP-HPLC to identify the special impurities...
August 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28805028/slow-and-steady-may-win-this-race
#13
EDITORIAL
James C Blankenship
This retrospective cohort study compares two strategies of stent delivery balloon inflation: inflation for 30 sec and longer as needed to stabilize the balloon pressure for 30 sec at the desired pressure, versus conventional fast inflation/fast deflation of the stent balloon The experimental technique decreased target vessel revascularization by about 50% as assessed by logistic regression and propensity analyses The investigators' recommendation to routinely use their prolonged inflation protocol is supported by six other studies over the past decade demonstrating that long stent balloon inflation produces better outcomes than does short inflation...
August 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28805023/onion-allium-cepa-l-peel-extract-ope-regulates-human-sperm-motility-via-protein-kinase-c-mediated-activation-of-the-human-voltage-gated-proton-channel
#14
M R Chae, S J Kang, K P Lee, B R Choi, H K Kim, J K Park, C Y Kim, S W Lee
Onion (Allium cepa L.) and quercetin protect against oxidative damage and have positive effects on multiple functional parameters of spermatozoa, including viability and motility. However, the associated underlying mechanisms of action have not yet been identified. The aim of this study was to investigate the effect of onion peel extract (OPE) on voltage-gated proton (Hv1) channels, which play a critical role in rapid proton extrusion. This process underlies a wide range of physiological processes, particularly male fertility...
August 13, 2017: Andrology
https://www.readbyqxmd.com/read/28801743/investigation-of-an-optimal-cell-lysis-method-for-the-study-of-the-zinc-metalloproteome-of-histoplasma-capsulatum
#15
Anna M Donnell, Stephanie Lewis, Sami Abraham, Kavitha Subramanian, Julio Landero Figueroa, George S Deepe, Anne P Vonderheide
This work sought to assess optimal extraction conditions in the study of the metalloproteome of the dimorphic fungus Histoplasma capsulatum. One of the body's responses to H. capsulatum infection is sequestration of zinc within host macrophage (MØ), as reported by Vignesh et al. (Immunity 39:697-710, 2013) and Vignesh et al. (PLOS Pathog 9:E1003815, 2013). Thus, metalloproteins containing zinc were of greatest interest as it plays a critical role in survival of the fungus. One challenge in metalloproteomics is the preservation of the native structure of proteins to retain non-covalently bound metals...
August 12, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28801070/methodological-considerations-for-the-temporal-summation-of-second-pain
#16
Nathanial R Eckert, Charles J Vierck, Corey B Simon, Sachell Calderon, Yenisel Cruz-Almeida, Roland Staud, Roger B Fillingim, Joseph L Riley
Temporal summation of second pain (TSSP) is a psychophysical indication of a central pain encoding mechanism, potentially enhanced in pathological pain conditions. Low frequency repetitive stimulation of unmyelinated (C) nociceptors results in a progressive increase of pain intensity when thermal stimulation intensity remains constant. However, when using different methods of nociceptive delivery to the skin, both regularity and rate of pain enhancement with repetition varies between experiments. Specifically, repetitive ramping up and down from a neutral to a painful temperature has produced weak and inconsistent pain summation...
August 8, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28800989/a-prospective-comparison-of-intraluminal-and-extraluminal-placement-of-the-9-french-arndt-bronchial-blocker-in-adult-thoracic-surgery-patients
#17
T Wesley Templeton, Benjamin N Morris, Eduardo J Goenaga-Diaz, Daniel J Forest, Rhett Hadley, Blake A Moore, Yvon F Bryan, Roger L Royster
OBJECTIVE: To compare the standard intraluminal approach with the placement of the 9-French Arndt endobronchial blocker with an extraluminal approach by measuring the time to positioning and other relevant intraoperative and postoperative parameters. DESIGN: A prospective, randomized, controlled trial. SETTING: University hospital. PARTICIPANTS: The study comprised 41 patients (20 intraluminal, 21 extraluminal) undergoing thoracic surgery...
August 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28800186/ameliorative-response-to-detoxification-psychotherapy-and-medical-management-in-patients-maintained-on-opioids-for-pain
#18
Molly Belkin, Howard Stephen Reinheimer, Jordan Levy, Brian Johnson
BACKGROUND AND OBJECTIVES: The prevalence of opioid-induced hyperalgesia (OIH) among patients maintained on opioids for chronic non-malignant pain has not been estimated. As a contribution toward establishing its prevalence, we report a case series of opioid maintained patients whose pain tolerance was measured by the cold pressor test at baseline. METHODS: A case series of 117 patients who had undergone detoxification was reviewed retrospectively. Most patients (n = 108) and selected non-addicted support persons who accompanied them (controls; n = 37) had cold pressor time (CPT) assessments at baseline...
August 11, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28800005/the-effects-of-british-army-footwear-on-ground-reaction-force-and-temporal-parameters-of-british-army-foot-drill
#19
Alex J Rawcliffe, Scott M Graham, Richard J Simpson, Gavin L Moir, Russell Jj Martindale, Stelios G Psycharakis, Chris Connaboy
High rates of occupational training-related lower-limb musculoskeletal [MSK] overuse injuries are reported for British Army recruits during basic training. Foot-drill is a repetitive impact loading occupational activity and involves striking the ground violently with an extended-knee [straight-leg] landing. Foot-drill produces vertical ground reaction forces [vGRF] equal to and/or greater than those reported for high-level plyometric exercises/activities. Shock absorbing footwear aid in the attenuation of the magnitude of vGRF, resulting in a reduced risk of lower-limb MSK overuse injury when running...
August 9, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28799759/extraction-of-glucuronoarabinoxylan-from-quinoa-stalks-chenopodium-quinoa-willd-and-evaluation-of-xylooligosaccharides-produced-by-gh10-and-gh11-xylanases
#20
Daniel Martin Salas-Veizaga, Rodrigo Villagomez, Javier A Linares-Pastén, Cristhian Álvaro Carrasco, Maria Teresa Álvarez, Patrick Adlercreutz, Eva Nordberg-Karlsson
Byproducts from quinoa are not yet well explored sources of hemicellulose or products thereof. In this work, xylan from milled quinoa stalks was retrieved to 66% recovery by akaline extraction using 0.5 M NaOH at 80°C, followed by ethanol precipitation. The isolated polymer eluted as a single peak in SEC with a molecular weight >700 kDa. Analysis by FT-IR and NMR, combined with acid hydrolysis to monomers, showed that the polymer was built of a backbone of β-(1,4) linked xylose residues that were substituted by 4-O-methylglucuronic acids, arabinose and galactose in an approximate molar ratio of 114:23:5:1...
August 11, 2017: Journal of Agricultural and Food Chemistry
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