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https://www.readbyqxmd.com/read/28101424/detection-and-classification-of-three-class-initial-dips-from-prefrontal-cortex
#1
Amad Zafar, Keum-Shik Hong
In this paper, the use of initial dips using functional near-infrared spectroscopy (fNIRS) for brain-computer interface (BCI) is investigated. Features and window sizes for detecting initial dips are also discussed. Three mental tasks including mental arithmetic, mental counting, and puzzle solving are performed in obtaining fNIRS signals from the prefrontal cortex. Vector-based phase analysis method combined with a threshold circle, as a decision criterion, are used to detect the initial dips. Eight healthy subjects participate in experiment...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28099764/the-posttraumatic-growth-inventory-a-revision-integrating-existential-and-spiritual-change
#2
Richard G Tedeschi, Arnie Cann, Kanako Taku, Emre Senol-Durak, Lawrence G Calhoun
Spiritual Change (SC) is one of 5 domains of posttraumatic growth (PTG). The current Posttraumatic Growth Inventory (PTGI) assesses this area of growth with only 2 items, one focusing on religiosity and the other focusing on spiritual understanding. The addition of 4 newly developed spiritual-existential change (SEC) items, creating an expanded PTGI (Posttraumatic Growth Inventory-X), reflects a diversity of perspectives on spiritual-existential experiences that are represented in different cultures. Samples were obtained from 3 countries: the United States (n = 250), Turkey (n = 502), and Japan (n = 314)...
January 18, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28099237/lower-limb-muscular-strength-balance-and-mobility-levels-in-adults-following-severe-thermal-burn-injuries
#3
Mohammed T A Omar, Amal M Abd El Baky, Anwar A Ebid
Severe burn injuries are associated with hypermetabolic response and increased catabolism. These lead to a vast loss of muscle mass and reduced muscle strength and function. Therefore, the aim of this study is to determine the impact of severe burn injuries on lower-limb muscular strength, balance, and mobility level in adults. Forty burned adults with burned TBSA (burned TBSA) ≥40% participated in this study. The peak torque and total work of quadriceps and knee flexors were calculated at 150°/sec using Biodex isokinetic dynamometer...
January 10, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28098499/inhibition-of-leishmania-infantum-trypanothione-reductase-by-diaryl-sulfide-derivatives
#4
Francesco Saccoliti, Gabriella Angiulli, Giovanni Pupo, Luca Pescatori, Valentina Noemi Madia, Antonella Messore, Gianni Colotti, Annarita Fiorillo, Luigi Scipione, Marina Gramiccia, Trentina Di Muccio, Roberto Di Santo, Roberta Costi, Andrea Ilari
The study presented here aimed at identifying a new class of compounds acting against Leishmania parasites, the causative agent of Leishmaniasis. For this purpose, the thioether derivatives of our in-house library have been evaluated in whole-cell screening assays in order to determine their in vitro activity against Leishmania protozoan. Among them, promising results have been achieved with compound RDS 777 (6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine) (IC50 = 29.43 µM), which is able to impair the mechanism of the parasite defence against the reactive oxygen species by inhibiting the trypanothione reductase (TR) with high efficiency (Ki 0...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28095109/test-retest-reliability-and-practice-effects-of-the-stability-evaluation-test
#5
Richelle M Williams, Matthew A Corvo, Kenneth C Lam, Travis A Williams, Lesley K Gilmer, Tamara C Valovich McLeod
CONTEXT: Postural control plays an essential role in concussion evaluation. The Stability Evaluation Test (SET) aims to objectively analyze postural control by measuring sway velocity on the NeuroCom's VSR portable force platform (Natus, San Carlos, CA). OBJECTIVE: To assess the test-retest reliability and practice effects of the SET protocol. DESIGN: Cohort. SETTING: Research Laboratory. PATIENTS OR OTHER PARTICIPANTS: Fifty healthy adults (males=20, females=30, age=25...
January 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28093501/discrete-cytosolic-macromolecular-braf-complexes-exhibit-distinct-activities-and-composition
#6
Britta Diedrich, Kristoffer Tg Rigbolt, Michael Röring, Ricarda Herr, Stephanie Kaeser-Pebernard, Christine Gretzmeier, Robert F Murphy, Tilman Brummer, Jörn Dengjel
As a central element within the RAS/ERK pathway, the serine/threonine kinase BRAF plays a key role in development and homeostasis and represents the most frequently mutated kinase in tumors. Consequently, it has emerged as an important therapeutic target in various malignancies. Nevertheless, the BRAF activation cycle still raises many mechanistic questions as illustrated by the paradoxical action and side effects of RAF inhibitors. By applying SEC-PCP-SILAC, we analyzed protein-protein interactions of hyperactive BRAF(V)(600E) and wild-type BRAF (BRAF(WT))...
January 16, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28092949/label-free-separation-of-induced-pluripotent-stem-cells-with-anti-ssea-1-antibody-immobilized-microfluidic-channel
#7
Akihisa Otaka, Kazuki Kitagawa, Takahiko Nakaoki, Mitsuhi Hirata, Kyoko Fukazawa, Kazuhiko Ishihara, Atsushi Mahara, Tetsuji Yamaoka
When induced pluripotent stem cell (iPSC) is routinely cultured, the obtained cells are a heterogeneous mixture, including feeder cells and partially differentiated cells. Therefore, a purification process is required to use them in a clinical stage. We described a label-free separation of iPSCs using a microfluidic channel. Antibodies against stage-specific embryonic antigen 1 (SSEA-1) was covalently immobilized on the channel coated with a phospholipid polymer. After injection of the heterogeneous cell suspension containing iPSCs, the velocity of cell movement under a liquid flow condition was measured...
January 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28092475/temperature-development-on-the-external-root-surface-during-laser-assisted-endodontic-treatment-applying-a-microchopped-mode-of-a-980%C3%A2-nm-diode-laser
#8
Franziska Beer, Eleftherios Terry R Farmakis, Josip Kopic, Christoph Kurzmann, Andreas Moritz
OBJECTIVE: The aim of this article was to investigate the temperature increase of the external root surface during laser-assisted endodontic treatment using a diode laser (980 nm) in a microchopped mode. METHODS: Ten freshly extracted, human maxillary incisors with mature apices were collected, prepared to size F4 at working length (ProTaper; Dentsply Maillefer, Ballaigues, Switzerland), mounted to a holder, and irradiated (using spiral movements in coronal direction) with a diode laser (GENTLEray 980 Classic Plus; KaVo, Biberach, Germany) with a 200 μm fiber in four different treatment groups: Group 1 (control group) was irradiated in six cycles of 5-sec irradiation/20-sec pause with 2...
January 12, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28091665/trace-element-protein-interactions-in-endolymph-from-the-inner-ear-of-fish-implications-for-environmental-reconstructions-using-fish-otolith-chemistry
#9
Oliver R B Thomas, Katherine Ganio, Blaine R Roberts, Stephen E Swearer
Otoliths, the biomineralised hearing "ear stones" from the inner ear of fish, grow throughout the lifespan of an individual, with deposition of alternating calciferous and proteinaceous bands occurring daily. Trace element : calcium ratios within daily increments measured by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) are often used in fisheries science to reconstruct environmental histories. There is, however, considerable uncertainty as to which elements are interacting with either the proteinaceous or calciferous zones of the otolith, and thus their utility as indicators of environmental change...
January 16, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28090435/-13-c-metabolomics-nmr-and-iroa-for-unknown-identification
#10
Chaevien S Clendinen, Gregory S Stupp, Bing Wang, Timothy J Garrett, Arthur S Edison
ABSTRACT BACKGROUND: Isotopic Ratio Outlier Analysis (IROA) is an untargeted metabolomics method that uses stable isotopic labeling and LC-HRMS for identification and relative quantification of metabolites in a biological sample under varying experimental conditions. OBJECTIVE: We demonstrate a method using high-sensitivity (13)C NMR to identify an unknown metabolite isolated from fractionated material from an IROA LC-HRMS experiment. METHODS: IROA samples from the nematode Caenorhabditis elegans were fractionated using LC-HRMS using 5 repeated injections and collecting 30 sec fractions...
August 2016: Current Metabolomics
https://www.readbyqxmd.com/read/28089758/pupil-responses-and-pain-ratings-to-heat-stimuli-reliability-and-effects-of-expectations-and-a-conditioning-pain-stimulus
#11
James C Eisenach, Regina Curry, Carol A Aschenbrenner, Robert C Coghill, Timothy T Houle
BACKGROUND: The locus coeruleus (LC) signals salience to sensory stimuli and these responses can modulate the experience of pain stimuli. The pupil dilation response (PDR) to noxious stimuli is thought to be a surrogate for LC responses, but PDR response to Peltier-controlled noxious heat stimuli, the most commonly used method in experimental pain research, has not been described. NEW METHOD: Healthy volunteers were presented with randomly presented heat stimuli of 5 sec duration and provided pain intensity ratings to each stimulus...
January 12, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28088896/formulation-and-optimization-of-lansoprazole-pellets-using-factorial-design-prepared-by-extrusion-spheronization-technique-using-carboxymethyl-tamarind-kernel-powder
#12
Sagar Sopanrao Muley, Tanaji Nandgude, Sushilkumar Poddar
BACKGROUND: In the present study, Lansoprazole pellets were prepared employing a novel excipient Carboxymethyl tamarind kernel powder (CMTKP) using extrusion-spheronization technique. Pellet formulation was optimized for formulation parameters (concentration of microcrystalline cellulose, CMTKP, croscarmellose sodium and isopropyl alcohol). METHODS: Process parameters (speed and duration of spheronization) were optimized using factorial design. The pellets were evaluated for yield, bulk and tapped density, particle size, hardness, drug content, disintegration time and drug release...
January 13, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28088460/ultrasound-mediated-delivery-of-rna-to-colonic-mucosa-of-live-mice
#13
Carl M Schoellhammer, Gregory Y Lauwers, Jeremy A Goettel, Matthias A Oberli, Cody Cleveland, June Y Park, Daniel Minahan, Yiyun Chen, Daniel G Anderson, Ana Jaklenec, Scott B Snapper, Robert Langer, Giovanni Traverso
BACKGROUND & AIMS: It is a challenge to deliver nucleic acids to gastrointestinal (GI) tissues due to their size and need for intracellular delivery. They are also extremely susceptible to degradation by nucleases, which are ubiquitous in the GI tract. We investigated whether ultrasound, which can permeabilize tissue through a phenomenon known as transient cavitation, can be used to deliver RNA to the colonic mucosa of living mice. METHODS: We investigated delivery of fluorescently labeled permeants to colon tissues of Yorkshire pigs ex vivo and mice in vivo...
January 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28087819/electrophysiologic-effects-of-the-ik1-inhibitor-pa-6-are-modulated-by-extracellular-potassium-in-isolated-guinea-pig-hearts
#14
Gregory S Hoeker, Mark A Skarsfeldt, Thomas Jespersen, Steven Poelzing
The pentamidine analog PA-6 was developed as a specific inward rectifier potassium current (IK1) antagonist, because established inhibitors either lack specificity or have side effects that prohibit their use in vivo. We previously demonstrated that BaCl2, an established IK1 inhibitor, could prolong action potential duration (APD) and increase cardiac conduction velocity (CV). However, few studies have addressed whether targeted IK1 inhibition similarly affects ventricular electrophysiology. The aim of this study was to determine the effects of PA-6 on cardiac repolarization and conduction in Langendorff-perfused guinea pig hearts...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28081477/pharmacokinetic-studies-of-active-triterpenoid-saponins-and-the-total-secondary-saponin-from-anemone-raddeana-regel
#15
Dandan Zhang, Tianli Lei, Chongning Lv, Huimin Zhao, Haiyan Xu, Jincai Lu
The rhizome of Anemone raddeana Regel, a Traditional Chinese Medicine (TCM) which has a robust history treating rheumatism and neuralgia. The total secondary saponin (TSS) from it has demonstrated antitumor activity. In this study, a rapid and validated LC-MS/MS method was developed to simultaneously determine the active compounds (Hederacolchiside A1 and Eleutheroside K). Analytes were separated on a reverse-phase C18 column with acetonitrile-water (5mmol/L ammonium acetate) as the mobile phase. This assay showed acceptable linearity (r>0...
January 3, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28077409/have-health-inequalities-changed-during-childhood-in-the-new-labour-generation-findings-from-the-uk-millennium-cohort-study
#16
Emeline Rougeaux, Steven Hope, Catherine Law, Anna Pearce
OBJECTIVES: To examine how population-level socioeconomic health inequalities developed during childhood, for children born at the turn of the 21st century and who grew up with major initiatives to tackle health inequalities (under the New Labour Government). SETTING: The UK. PARTICIPANTS: Singleton children in the Millennium Cohort Study at ages 3 (n=15 381), 5 (n=15 041), 7 (n=13 681) and 11 (n=13 112) years. PRIMARY OUTCOMES: Relative (prevalence ratios (PR)) and absolute health inequalities (prevalence differences (PD)) were estimated in longitudinal models by socioeconomic circumstances (SEC; using highest maternal academic attainment, ranging from 'no academic qualifications' to 'degree' (baseline))...
January 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28074788/comparison-of-two-doses-of-heparin-on-outcome-in-off-pump-coronary-artery-bypass-surgery-patients-a-prospective-randomized-control-study
#17
Murali Chakravarthy, Dattatreya Prabhakumar, Patil Thimmannagowda, Jayaprakash Krishnamoorthy, Antony George, Vivek Jawali
INTRODUCTION: While off pump coronary artery bypass surgery is practiced with an intention to reduce the morbidity associated with cardiopulmonary bypass, the resultant 'hypercoagulability' needs to be addressed. Complications such as cavitary thrombus possibly due to the hyper coagulability after off pump coronary artery bypass surgery have been described. Many clinicians use higher doses of heparin - up to 5 mg/kg in order to thwart this fear. Overall, there appears to be no consensus on the dose of heparin in off pump coronary artery bypass surgeries...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28074334/saliva-versus-plasma-bioequivalence-of-azithromycin-in-humans-validation-of-class-i-drugs-of-the-salivary-excretion-classification-system
#18
Nasir Idkaidek, Tawfiq Arafat, Hazim Hamadi, Salim Hamadi, Ibrahim Al-Adham
AIM: The aim of this study was to compare human pharmacokinetics and bioequivalence metrics in saliva versus plasma for azithromycin as a model class I drug of the Salivary Excretion Classification System (SECS). METHODS: A pilot, open-label, two-way crossover bioequivalence study was done, and involved a single 500-mg oral dose of azithromycin given to eight healthy subjects under fasting conditions, followed by a 3-week washout period. Blood and unstimulated saliva samples were collected over 72 h and deep frozen until analysis by a validated liquid chromatography with mass spectroscopy method...
January 10, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28073066/unique-optical-properties-of-eu-3-doped-l-histidine-hydrochloride-mono-hydrate-single-crystals-from-low-temperature-growth-technique
#19
K Ramachandra Rao, S Rajyalakshmi, Ch Satya Kamal, B Brahmaji, Jacek B Jasinski, T K Visweswara Rao
A low-temperature solution method was utilized to grow single crystals of Eu(3+)doped l-histidine hydrochloride monohydrate. The quality of the crystals was confirmed by high-resolution X-ray diffraction measurements with full width at half maximum (FWHM) of rocking curve at 8arc per sec. The incorporation of Eu(3+) ions into the lattice was confirmed by functional group analysis using Fourier Transform Infrared (FTIR) spectroscopy. The amount of Eu(3+) ions was found to be 0.08 weight (%) using energy dispersive X-ray analysis...
December 30, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28069921/visual-stimulus-speed-does-not-influence-the-rapid-emergence-of-direction-selectivity-in-ferret-visual-cortex
#20
Neil J Ritter, Nora M Anderson, Stephen D Van Hooser
: Sensory experience is necessary for the development of some receptive field properties of neurons in primary sensory cortical areas. However, it remains unclear whether the parameters of an individual animal's experience play an instructive role and influence the tuning parameters of cortical sensory neurons as selectivity emerges, or rather if experience merely permits the completion of processes that are fully seeded at the onset of experience. Here we have examined whether the speed of visual stimuli that are presented to visually naïve ferrets can influence the parameters of speed tuning and direction selectivity in cortical neurons...
January 9, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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