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https://www.readbyqxmd.com/read/29332261/is-the-laser-mightier-than-the-sword-a-comparative-study-for-the-urethrotomy
#1
Coen Holzhauer, Anita W T M Roelofs, Arjen C Kums, Philip C Weijerman, Michael R van Balken
PURPOSE: The knife is the most common used instrument for endoscopic urethrotomy. Unfortunately, there are high recurrence rates; it is thought that a laser reduces those rates. We compared the two techniques in this retrospective study. MATERIALS AND METHODS: Between 2010 and 2014, 127 patients were operated on with the knife (KG) and for 65 patients, the laser (LG) was used. We scored the complexity of the stricture using the UREThRAL stricture score (USS) and we scored if a treatment was successful...
January 13, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29331015/detection-of-human-disease-conditions-by-single-cell-morpho-rheological-phenotyping-of-blood
#2
Nicole Toepfner, Christoph Herold, Oliver Otto, Philipp Rosendahl, Angela Jacobi, Martin Kräter, Julia Stächele, Leonard Menschner, Maik Herbig, Laura Ciuffreda, Lisa Ranford-Cartwright, Michal Grzybek, Ünal Coskun, Elisabeth Reithuber, Genevieve Garriss, Peter Mellroth, Birgitta Henriques Normark, Nicola Tregay, Meinolf Suttorp, Martin Bornhäuser, Edwin R Chilvers, Reinhard Berner, Jochen Guck
Blood is arguably the most important bodily fluid and its analysis provides crucial health status information. A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining the frequency of all major blood cells. What is lacking to advance initial blood diagnostics is an unbiased and quick functional assessment of blood that can narrow down the diagnosis and generate specific hypotheses. To address this need, we introduce the continuous, cell-by-cell morpho-rheological (MORE) analysis of diluted whole blood, without labeling, enrichment or separation, at rates of 1,000 cells/sec...
January 13, 2018: ELife
https://www.readbyqxmd.com/read/29330911/title-prognostic-significance-of-arterial-stiffness-and-osteoprotegerin-in-patients-with-stable-coronary-artery-disease
#3
Gerasimos Siasos, Evangelos Oikonomou, Konstantinos Maniatis, Georgios Georgiopoulos, Eleni Kokkou, Vasiliki Tsigkou, Marina Zaromitidou, Alexis Antonopoulos, Manolis Vavuranakis, Christodoulos Stefanadis, Athanasios G Papavassiliou, Dimitris Tousoulis
BACKGROUND: Arterial stiffness and vascular calcification significantly contribute to coronary atherosclerosis progression. The prognostic value of increased arterial stiffness and vascular calcification in subjects with stable coronary artery disease (CAD) after percutaneous coronary intervention(PCI) is currently under question. MATERIALS AND METHODS: We randomly enrolled 262 patients with stable CAD one month after successful PCI. Carotid femoral pulse wave velocity (PWV) was measured as a well-established index of central aortic stiffness...
January 13, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29330604/driving-forces-of-translocation-through-bacterial-translocon-secyeg
#4
Denis G Knyazev, Roland Kuttner, Mirjam Zimmermann, Ekaterina Sobakinskaya, Peter Pohl
This review focusses on the energetics of protein translocation via the Sec translocation machinery. First we complement structural data about SecYEG's conformational rearrangements by insight obtained from functional assays. These include measurements of SecYEG permeability that allow assessment of channel gating by ligand binding and membrane voltage. Second we will discuss the power stroke and Brownian ratcheting models of substrate translocation and the role that the two models assign to the putative driving forces: (i) ATP (SecA) and GTP (ribosome) hydrolysis, (ii) interaction with accessory proteins, (iii) membrane partitioning and folding, (iv) proton motive force (PMF), and (v) entropic contributions...
January 12, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29330529/the-interaction-network-of-the-yidc-insertase-with-the-secyeg-translocon-srp-and-the-srp-receptor-ftsy
#5
Narcis-Adrian Petriman, Benjamin Jauß, Antonia Hufnagel, Lisa Franz, Ilie Sachelaru, Friedel Drepper, Bettina Warscheid, Hans-Georg Koch
YidC/Oxa1/Alb3 are essential proteins that operate independently or cooperatively with the Sec machinery during membrane protein insertion in bacteria, archaea and eukaryotic organelles. Although the interaction between the bacterial SecYEG translocon and YidC has been observed in multiple studies, it is still unknown which domains of YidC are in contact with the SecYEG translocon. By in vivo and in vitro site-directed and para-formaldehyde cross-linking we identified the auxiliary transmembrane domain 1 of E...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329926/characterization-of-selenoprotein-p-cdna-of-the-antarctic-toothfish-dissostichus-mawsoni-and-its-role-under-cold-pressure
#6
Yan Li, Juntao Luo, Qiongqiong Xu, Yanwen Hou, Penglei Jiang, Yutian Sun, Hanxu Lu, Bingshe Han, Junfang Zhang
Our previous study using comparative genome analysis revealed a significant gene copy number gain of Dissostichus mawsoni selenoprotein P (Dm-SEPP) during the evolutionary radiation of Antarctic notothenioids, suggesting that Dm-SEPP contribute to this process, but the detailed structure and function of this gene product remain unclear. In the present study, the Dm-SEPP cDNA was cloned and characterized. The Dm-SEPP cDNA contains 17 selenocysteines (Sec) encoded by TGA codons and 2 typical SECIS elements located in the 3'-UTR...
January 9, 2018: Gene
https://www.readbyqxmd.com/read/29329093/size-exclusion-chromatography-sec-hplc-as-an-alternative-to-study-thrombin-inhibition
#7
Emmanuel Pérez-Escalante, Luis Guillermo González-Olivares, Alma Elizabeth Cruz-Guerrero, Carlos Andrés Galán-Vidal, Ma Elena Páez-Hernández, Giaan Arturo Álvarez-Romero
In vitro analysis of anticoagulant compounds with a potential use as antithrombotic drugs, has been traditionally performed using techniques like spectrophotometry, turbidimetry, as well as electrochemical and clinical assays. Although, these techniques have some disadvantages such as: the inability to measure the total biological activity of thrombin, interferences and, sometimes, the quantitative determination of the inhibition ratio is not accurate. In the present work, the conversion of fibrinogen to fibrin was monitored by molecular exclusion chromatography (SEC-HPLC) in three different reaction systems...
January 6, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29326905/neuromuscular-features-in-sprinters-with-cerebral-palsy-case-studies-based-on-paralympic-classification
#8
Diego Antunes, Mateus Rossato, Rafael Lima Kons, Raphael Luiz Sakugawa, Gabriela Fischer
Despite the evolution of runner performance in athletes with cerebral palsy (CP), little is known about neuromuscular parameters of sprinters from different classes, especially related to power output, muscular imbalances and asymmetry indexes in lower limbs. The aim of this study was to assess muscle power, muscular imbalance and asymmetry in sprinters with CP. Four male sprinters with CP (age, 18 to 27 years; body mass, 58.5 to 72.8 kg; height, 161.5 to 174 cm) classified as T38, T37, T36, T35 according to International Paralympic Committee functional classification, performed vertical counter movement jump and squat jump on force plate and isokinetic torque evaluations in both limbs...
December 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29326899/effectiveness-of-a-multimodal-exercise-rehabilitation-program-on-walking-capacity-and-functionality-after-a-stroke
#9
Montserrat Grau Pellicer, Andrés Chamarro Lusar, Josep Medina Casanovas, Bernat-Carles Serdà Ferrer
The aim of this study was to determine the effectiveness of a 12-week multimodal exercise rehabilitation program on walking speed, walking ability and activities of daily living (ADLs) among people who had suffered a stroke. Thirty-one stroke survivors who had completed a conventional rehabilitation program voluntarily participated in the study. Twenty-six participants completed the multimodal exercise rehabilitation program (2 days/wk, 1 hr/session). Physical outcome measures were: walking speed (10-m walking test), walking ability (6-min walking test and functional ambulation classification) and ADLs (Barthel Index)...
December 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29325794/association-of-posture-and-ambulation-with-function-at-30-days-post-hospital-discharge-in-older-adults-with-heart-failure
#10
Theresa A Floegel, Jared M Dickinson, Cheryl DerAnanian, Marianne McCarthy, Steven P Hooker, Matthew P Buman
PURPOSE: To investigate the predictive value of in-hospital posture and ambulatory activity for 30-d following discharge on functional status in older patients with heart failure. METHODS: Prospective observational pilot study of 27 patients (78 ± 9.8yrs; 51.8% female) admitted with heart failure. Participants wore two inclinometric accelerometers to record posture in-hospital, and an ankle accelerometer to record ambulatory activity in-hospital and 30 days after discharge...
January 8, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29325501/venous-hemodynamics-assessed-with-air-plethysmography-in-legs-with-lymphedema
#11
Kotaro Suehiro, Noriyasu Morikage, Koshiro Ueda, Makoto Samura, Yuriko Takeuchi, Takashi Nagase, Takahiro Mizoguchi, Kaori Nakamura, Kimikazu Hamano
This study was conducted to identify specific abnormalities using the results from air plethysmography in legs with lymphedema. A routine air plethysmography exercise protocol was performed in 31 patients with unilateral leg lymphedema, and the results were compared with those of 53 patients with unilateral great saphenous vein reflux and 15 normal subjects. The venous filling index in legs with lymphedema (2.1 ± 1.2 mL/sec) was smaller than in legs with great saphenous vein reflux (6.4 ± 4.1 mL/sec, p < 0...
January 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29324912/diuresis-renography-and-ultrasonography-in-children-with-antenatally-detected-hydronephrosis-can-support-diagnoses-and-suggest-related-surgery-treatment
#12
M Radulović, S Beatović, M Janković, Dragana Šobić-Šaranović, Vera Artiko, Boris Ajdinović
OBJECTIVE: Prenatal ultrasound (US) screening detects the hydronephrosis (HN)-dilatation of fetal renal collecting system in 1%-5% of all pregnancies. In most children, HN is detected by prenatal US screening between 18-20 gestational week. Pelvi- ureteric junction (PUJ) stenosis is the most common etiological factor of prenatal HN and requires postnatal follow-up. Diuresis renography plays important role in the follow-up by complementing morphological information obtained by US with the data about differential renal function (DRF) and drainage...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29323455/selenocysteine-inhibits-human-osteosarcoma-cells-growth-through-triggering-mitochondrial-dysfunction-and-ros-mediated-p53-phosphorylation
#13
Wei Wang, Fan-Bin Meng, Zhen-Xing Wang, Xiao Li, Dong-Sheng Zhou
Osteosarcoma represents the most common primary malignant bone tumor in children and adolescents, which shows severe resistance towards standard chemotherapy because of high invasive capacity and growing incidence. Selenocystine (SeC) is a naturally available Se-containing amino acid that displays splendid anticancer activities against several human tumors. However, little information about SeC-induced growth inhibition against human osteosarcoma is available. Herein, the anticancer efficiency and underlying mechanism of SeC against human osteosarcoma were evaluated in vitro and in vivo...
January 11, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29320626/directing-nanoparticle-biodistribution-through-evasion-and-exploitation-of-stab2-dependent-nanoparticle-uptake
#14
Frederick Campbell, Frank L Bos, Sandro Sieber, Gabriela Arias-Alpizar, Bjørn E Koch, Jörg Huwyler, Alexander Kros, Jeroen Bussmann
Up to 99% of systemically administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells), although significant nanoparticle interactions with other hepatic cells have also been observed. To achieve effective cell-specific targeting of drugs through nanoparticle encapsulation, improved mechanistic understanding of nanoparticle-liver interactions is required. Here, we show the caudal vein of the embryonic zebrafish (Danio rerio) can be used as a model for assessing nanoparticle interactions with mammalian liver sinusoidal (or scavenger) endothelial cells (SECs) and macrophages...
January 10, 2018: ACS Nano
https://www.readbyqxmd.com/read/29319734/a-prototype-single-port-device-for-pressurized-intraperitoneal-aerosol-chemotherapy-technical-feasibility-and-local-drug-distribution
#15
Rafael Seitenfus, Paulo Roberto Walter Ferreira, Gabriel Oliveira Dos Santos, Rafael José Vargas Alves, Antonio Nocchi Kalil, Eduardo Dipp de Barros, Olivier Glehen, Thaís Andrade Costa Casagrande, Eduardo Aimoré Bonin, Edison Martins da Silva Junior
PURPOSE: To evaluate the technical feasibility and homogeneity of drug distribution of pressurized intraperitoneal aerosol chemotherapy (PIPAC) based on a novel process of intraperitoneal drug application (multidirectional aerosolization). METHODS: This was an in vivo experimental study in pigs. A single-port device was manufactured at the smallest diameter possible for multidirectional aerosolization of the chemotherapeutic drug under positive intraperitoneal pressure...
December 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29319509/prevalence-influencing-factors-antibiotic-resistance-toxin-and-molecular-characteristics-of-staphylococcus-aureus-and-mrsa-nasal-carriage-among-diabetic-population-in-the-united-states-2001-2004
#16
Jialing Lin, Yang Peng, Chan Bai, Ting Zhang, Haoqu Zheng, Xiaojie Wang, Jiaping Ye, Xiaohua Ye, Ying Li, Zhenjiang Yao
Diabetic population were reported more likely to suffer carriage and infection with Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA) than non-diabetic population. We aim to elucidate the prevalence and characteristics of S. aureus and MRSA nasal carriage among diabetic population in the United States National Health and Nutrition Examination Survey, 2001-2004. Univariate analyses were conducted using Chi-square test, Fisher's exact probability test or student t test, as appropriate...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29319507/inhibition-of-multidrug-resistant-gram-positive-and-gram-negative-bacteria-by-a-photoactivated-porphyrin
#17
Moreno Bondi, Anna Mazzini, Simona de Niederhäusern, Ramona Iseppi, Patrizia Messi
The authors studied the in vitro antibacterial activity of the photo-activated porphyrin meso-tri(N-methyl-pyridyl), mono(N-tetradecyl-pyridyl)porphine (C14) against four multidrug-resistant bacteria: Staphylococcus aureus, Enterococcus faecalis (Gram-positive), Escherichia coli, Pseudomonas aeruginosa (Gram-negative). Using 10 μg/ml of porphyrin and 60 sec irradiation we observed the remarkable susceptibility of S. aureus and E. faecalis to treatment while, under the same conditions, E. coli and P. aeruginosa showed very low susceptibility...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29318791/impact-of-balloon-pulmonary-angioplasty-on-hemodynamics-and-clinical-outcomes-in-patients-with-chronic-thromboembolic-pulmonary-hypertension-the-initial-korean-experience
#18
Woochan Kwon, Jeong Hoon Yang, Taek Kyu Park, Sung A Chang, Dong Seop Jung, Young Seok Cho, Sung Mok Kim, Tae Jung Kim, Hye Yoon Park, Seung Hyuk Choi, Duk Kyung Kim
BACKGROUND: The treatment of choice for chronic thromboembolic pulmonary hypertension (CTEPH) is pulmonary endarterectomy (PEA). However, not all patients are eligible for PEA, and some patients experience recurrence of pulmonary hypertension even after PEA. METHODS: Patients who underwent balloon pulmonary angioplasty (BPA) between December 2015 and April 2017 were enrolled from the Samsung Medical Center CTEPH registry. Enrolled patients underwent right heart catheterization, echocardiography, and 6-minute walk distance (6MWD) at baseline, 4 and 24 weeks after their first BPA session...
January 22, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29318099/a-small-molecule-impedes-insulin-fibrillation-another-new-role-of-phenothiazine-derivatives
#19
Meghomukta Mukherjee, Jagannath Jana, Subhrangsu Chatterjee
Protein misfolding is interrelated to several diseases, including neurodegenerative diseases and type II diabetes. Misfolded/unfolded proteins produce soluble oligomers that accumulate into "amyloid plaques". Inhibition of amyloid-plaque formation by those misfolded/unfolded proteins will lead to the invention of new therapeutic approaches for amyloid-related diseases. Herein, methylene blue (MB), a well-defined drug against multiple diseases and disorders, is used to impede insulin fibrillation. In this study, we perform an array of in vitro experiments to monitor the effects of MB on the fibrillation of bovine insulin...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29317351/a-new-physiological-model-for-studying-the-effect-of-chest-compression-and-ventilation-during-cardiopulmonary-resuscitation-the-thiel-cadaver
#20
Emmanuel Charbonney, Stéphane Delisle, Dominique Savary, Gilles Bronchti, Marceau Rigollot, Adrien Drouet, Bilal Badat, Paul Ouellet, Patrice Gosselin, Alain Mercat, Laurent Brochard, Jean-Christophe M Richard
BACKGROUND: Studying ventilation and intrathoracic pressure (ITP) induced by chest compressions (CC) during Cardio Pulmonary Resuscitation is challenging and important aspects such as airway closure have been mostly ignored. We hypothesized that Thiel Embalmed Cadavers could constitute an appropriate model. METHODS: We assessed respiratory mechanics and ITP during CC in 11 cadavers, and we compared it to measurements obtained in 9 out-of-hospital cardiac arrest patients and to predicted values from a bench model...
January 6, 2018: Resuscitation
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