keyword
MENU ▼
Read by QxMD icon Read
search

UPR

keyword
https://www.readbyqxmd.com/read/29230015/a-perk-mir-211-axis-suppresses-circadian-regulators-and-protein-synthesis-to-promote-cancer-cell-survival
#1
Yiwen Bu, Akihiro Yoshida, Nilesh Chitnis, Brian J Altman, Feven Tameire, Amanda Oran, Victoria Gennaro, Kent E Armeson, Steven B McMahon, Gerald B Wertheim, Chi V Dang, Davide Ruggero, Constantinos Koumenis, Serge Y Fuchs, J Alan Diehl
The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR signalling interfaces with the circadian clock. UPR activation induces a 10 h phase shift in circadian oscillations through induction of miR-211, a PERK-inducible microRNA that transiently suppresses both Bmal1 and Clock, core circadian regulators. Molecular investigation reveals that miR-211 directly regulates Bmal1 and Clock via distinct mechanisms...
December 11, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/29220068/assessing-the-decrease-in-the-surgical-population-of-the-university-of-puerto-rico-affiliated-hospitals
#2
Norma I Cruz, Elvis Santiago, César Luque
OBJECTIVE: To evaluate the magnitude of the decrease in the surgical population of the University of Puerto Rico (UPR)-affiliated hospitals. METHODS: We examined all the surgical cases that were entered into the Surgical Database from January 1, 2013, through December 31, 2015. This database collects patient and procedural information from the surgical services of the UPR-affiliated hospitals. Thus, the number of surgical patients for the 3-year study period was determined and their characteristics recorded...
December 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29220063/preventive-care-screening-in-the-puerto-rican-geriatric-population-a-formative-evaluation-of-patient-knowledge
#3
Vanessa Sepúlveda-Rivera, Christian Donato-Santana, Gil Diaz-Vega
OBJECTIVE: This study was meant to be the first step in bridging a gap in the literature concerning Puerto Rican geriatric patients' levels of knowledge concerning 4 preventive care screening tests: mammography, bone densitometry, colonoscopy, and lipid panels. METHODS: Patients 65 years old and older were interviewed at the University of Puerto Rico (UPR), Medical Sciences Campus, primary care clinics. Fisher's exact test was used to assess knowledge status for each screening test...
December 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29207602/the-trpv1-ion-channel-regulates-thymocyte-differentiation-by-modulating-autophagy-and-proteasome-activity
#4
Consuelo Amantini, Valerio Farfariello, Claudio Cardinali, Maria Beatrice Morelli, Oliviero Marinelli, Massimo Nabissi, Matteo Santoni, Laura Bonfili, Valentina Cecarini, Anna Maria Eleuteri, Giorgio Santoni
Autophagy and the ubiquitin-proteasome system (UPS) control thymus cell homeostasis under resting and endoplasmic reticulum (ER) stress conditions. Several evidence support a cross-talk between UPS and autophagy; abrogation of UPS responses stimulates autophagy, and vice versa the inhibition of autophagy alters the UPS functions. Herein, we found that TRPV1 activation induces ER stress, proteasome dysfunction and autophagy in thymocytes by modulating the expression of UPR-related genes. The TRPV1-mediated autophagy prevents the UPR activation by inhibiting BiP, Grp94 and ERp57 chaperone protein expression...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207179/arctigenin-induces-the-apoptosis-of-primary-effusion-lymphoma-cells-under-conditions-of-glucose-deprivation
#5
Yusuke Baba, Zenpei Shigemi, Naoko Hara, Misato Moriguchi, Marina Ikeda, Tadashi Watanabe, Masahiro Fujimuro
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of primary effusion lymphoma (PEL) and Kaposi's sarcoma. PEL is a type of non-Hodgkin's B-cell lymphoma, affecting immunosuppressed individuals, such as post-transplant or AIDS patients. However, since PEL is resistant to chemotherapeutic regimens, new effective treatment strategies are required. Arctigenin, a natural lignan compound found in the plant Arctium lappa, has been widely investigated as a potential anticancer agent in the clinical setting...
December 1, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29206294/hormone-regulates-endometrial-function-via-cooperation-of-endoplasmic-reticulum-stress-and-mtor-autophagy
#6
Diqi Yang, Tingting Jiang, Jianguo Liu, Jin Hong, Pengfei Lin, Huatao Chen, Dong Zhou, Keqiong Tang, Aihua Wang, Yaping Jin
In ruminant, the receptive endometrium and the elongation of the hatched blastocyst are required to complete the process of implantation. However, the mechanisms regulating goat endometrial function during the peri-implantation period of pregnancy are still unclear. In this study, EECs were treated with progesterone, estradiol and interferon-tau (IFNT). We have found that endoplasmic reticulum (ER) stress were activated under hormones treatment. To identify the cellular mechanism of regulation of endometrial function, we investigated the effect of ER stress activator thapsigargin (TG) and inhibitor 4 phenyl butyric acid (4-PBA) on EECs...
December 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29205032/apratyramide-a-marine-derived-peptidic-stimulator-of-vegf-a-and-other-growth-factors-with-potential-application-in-wound-healing
#7
Weijing Cai, Lilibeth A Salvador-Reyes, Wei Zhang, Qi-Yin Chen, Susan Matthew, Ranjala Ratnayake, Soo Jung Seo, Simon Dolles, Daniel J Gibson, Valerie J Paul, Hendrik Luesch
A novel linear depsipeptide enriched with tyrosine-derived moieties, termed apratyramide, was isolated from an apratoxin-producing cyanobacterium. The structure was determined using a combination of NMR spectroscopy, mass spectrometry, and chiral analysis of the acid hydrolyzate and confirmed by total synthesis. Apratyramide up-regulated multiple growth factors at the transcript level in human keratinocyte (HaCaT) cells and induced the secretion of vascular endothelial growth factor A (VEGF-A) from HaCaT cells, suggesting the compound's potential wound-healing properties through growth factor induction...
December 5, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29199180/docosahexaenoic-acid-counteracts-palmitate-induced-endoplasmic-reticulum-stress-in-c2c12-myotubes-impact-on-muscle-atrophy
#8
Myra E Woodworth-Hobbs, Ben D Perry, Jill A Rahnert, Matthew B Hudson, Bin Zheng, S Russ Price
Lipid accumulation in skeletal muscle results in dysregulation of protein metabolism and muscle atrophy. We previously reported that treating C2C12 myotubes with palmitate (PA), a saturated fatty acid, increases the overall rate of proteolysis via activation of the ubiquitin-proteasome and autophagy systems; co-treatment with the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) prevents the PA-induced responses. Others have reported that PA induces endoplasmic reticulum (ER) stress which initiates the unfolded protein response (UPR), a collective group of responses that can lead to activation of caspase-mediated proteolysis and autophagy...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29198525/a-j-protein-co-chaperone-recruits-bip-to-monomerize-ire1-and-repress-the-unfolded-protein-response
#9
Niko Amin-Wetzel, Reuben A Saunders, Maarten J Kamphuis, Claudia Rato, Steffen Preissler, Heather P Harding, David Ron
When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response (UPR) increases ER-protein-folding capacity to restore protein-folding homeostasis. Unfolded proteins activate UPR signaling across the ER membrane to the nucleus by promoting oligomerization of IRE1, a conserved transmembrane ER stress receptor. However, the coupling of ER stress to IRE1 oligomerization and activation has remained obscure. Here, we report that the ER luminal co-chaperone ERdj4/DNAJB9 is a selective IRE1 repressor that promotes a complex between the luminal Hsp70 BiP and the luminal stress-sensing domain of IRE1α (IRE1LD)...
November 30, 2017: Cell
https://www.readbyqxmd.com/read/29197639/a-promising-natural-product-pristimerin-results-in-cytotoxicity-against-breast-cancer-stem-cells-in-vitro-and-xenografts-in-vivo-through-apoptosis-and-an-incomplete-autopaghy-in-breast-cancer
#10
Buse Cevatemre, Merve Erkısa, Nazlihan Aztopal, Didem Karakas, Pınar Alper, Chrisiida Tsimplouli, Evangelia Sereti, Konstantinos Dimas, Elif I Ikitimur Armutak, Ebru Gurel Gurevin, Ayca Uvez, Mattia Mori, Simone Berardozzi, Cinzia Ingallina, Ilaria D'Acquarica, Bruno Botta, Bulent Ozpolat, Engin Ulukaya
Several natural products have been suggested as effective agents for the treatment of cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy hypothesis, it is worth investigating the effects of pristimerin on CSCs as well as on the other malignant cells (MCF-7 and MDA-MB-231) of breast cancer. The anti-growth activity of pristimerin against MCF-7 and MCF-7s (cancer stem cell enriched population) cells was investigated by real time viability monitorization (xCELLigence System®) and ATP assay, respectively...
December 1, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29197516/protopanaxadiol-derivative-ddpu-improves-behavior-and-cognitive-deficit-in-ad-mice-involving-regulation-of-both-er-stress-and-autophagy
#11
Xiaodan Guo, Jianlu Lv, Jian Lu, Lei Fan, Xi Huang, Lihong Hu, Jiaying Wang, Xu Shen
Alzheimer's disease (AD) is a progressively neurodegenerative disease with typical hallmarks of amyloid β (Aβ) plaque accumulation, neurofibrillary tangle (NFT) formation and neuronal death extension. Aggressive Aβ accumulation promotes senile plaque formation and perturbs endoplasmic reticulum (ER) function to trigger the unfolded protein response (UPR) leading to neuronal apoptosis. The stress-dependent activation of protein kinase RNA-like endoplasmic reticulum kinase (PERK) increases the phosphorylation of eukaryotic translation initiation factor-2α (eIF2α) to promote the preferential synthesis of β-site APP cleavage enzyme 1 (BACE1) and Aβ generation in turn...
November 29, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29194946/greetings-from-the-endoplasmic-reticulum-er-escaping-er-thiol-isomerases-regulate-thrombosis
#12
Beate E Kehrel, Anke C Fender
The unfolded protein response (UPR) is the primary cellular mechanism to ensure proteostasis, that is, the correct regulation of protein biosynthesis, folding, trafficking and degradation. The UPR is triggered by the accumulation of unfolded or misfolded proteins within the endopasmic reticulum (ER), and is characterized by the induction of chaperones, degradation of incorrectly folded proteins, and halting protein translation. Major chaperones activated by the UPR include calreticulin, certain heat shock proteins (HSP) such as the glucose regulated proteins GRP78 and GRP79, and the thiol isomerases...
December 1, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29190976/celastrol-induces-apoptosis-in-hepatocellular-carcinoma-cells-via-targeting-er-stress-upr
#13
Bo Ren, Hui Liu, Hang Gao, Shutong Liu, Zehui Zhang, Andrew M Fribley, Michael U Callaghan, Zhixiang Xu, Qinghua Zeng, Yulin Li
Hepatocellular carcinoma (HCC) is one of the most serious and deadly diseases worldwide with limited options for effective treatment. Biomarker-based active compound targeting therapy may shed some light on novel drugs for HCC. The endoplasmic reticulum (ER) stress and unfolded protein response (UPR) play important roles in the regulation of cell fate and have become novel signaling targets for the development of anticancer drugs. Celastrol, a triterpene from traditional Chinese medicine, has been reported to possess anti-tumor effects on various cancers...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29190024/methods-for-analyzing-endoplasmic-reticulum-stress-in-the-trabecular-meshwork-of-glaucoma-models
#14
Prabhavathi Maddineni, Ramesh B Kasetti, Gulab S Zode
The pathological mechanisms underlying increased outflow resistance at the trabecular meshwork (TM) that is responsible for elevating intraocular pressure (IOP) have not been fully delineated. Recent studies have shown that progressive accumulation of misfolded proteins and induction of endoplasmic reticulum (ER) stress is associated with the pathophysiology of glaucomatous TM damage and IOP elevation. We have shown that known causes of human glaucoma, including expression of mutant myocilin or dexamethasone treatment induce abnormal protein accumulation and ER stress in the TM in vitro and in vivo models...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29186961/relationship-between-ppp1r15a-gene-polymorphism-rs611251-and-epstein-barr-virus-associated-tumors
#15
Y Song, S Liu, Z Zhao, Y Zhang, Y Yang, B Luo
Protein phosphatase 1, regulatory subunit 15A (PPP1R15A), also known as growth arrest and DNA damage-inducible protein GADD34, plays a vital role in promoting cell death and the unfolded protein response (UPR). In order to explore whether the SNP (rs611251) of PPP1R15A gene has a role in different types of Epstein-Barr virus (EBV) - associated tumors, we detected the PPP1R15A gene rs611251 polymorphism in 195 cases of EBV positive tumors (93 lymphomas, 48 gastric carcinomas, 54 nasopharyngeal carcinomas), 208 cases of EBV-negative tumors (136 gastric carcinoma, 19 nasopharyngeal carcinomas, 53 lymphomas) and 113 peripheral blood samples from healthy individuals...
2017: Acta Virologica
https://www.readbyqxmd.com/read/29184100/akt-mtor-signaling-modulates-the-dynamics-of-ire1-rnase-activity-by-regulating-er-mitochondria-contacts
#16
Miguel Sanchez-Alvarez, Miguel Angel Del Pozo, Chris Bakal
Inositol Requiring Enzyme-1 (IRE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanism that ensures homeostasis of the endoplasmic reticulum (ER) in eukaryotes. IRE1 activation orchestrates adaptive responses, including lipid anabolism, metabolic reprogramming, increases in protein folding competency, and ER expansion/remodeling. However, we still know surprisingly little regarding the principles by which this ER transducer is deactivated upon ER stress clearance...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29181405/review-of-natural-product-derived-compounds-as-potent-antiglioblastoma-drugs
#17
REVIEW
Moon Nyeo Park, Hyo Sook Song, Myungsun Kim, Min-Jung Lee, Whisung Cho, Hyun-Jin Lee, Cho-Hyun Hwang, Soojong Kim, Yechae Hwang, Beomku Kang, Bonglee Kim
Common care for glioblastoma multiforme (GBM) is a surgical resection followed by radiotherapy and temozolomide- (TMZ-) based chemotherapy. Unfortunately, these therapies remain inadequate involving severe mortality and recurrence. Recently, new approaches discovering combinations of multiple inhibitors have been proposed along with the identification of key driver mutations that are specific to each patient. To date, this approach is still limited by the lack of effective therapy. Hopefully, novel compounds derived from natural products are suggested as potential solutions...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29176575/phosphorylation-of-lamp2a-by-p38-mapk-couples-er-stress-to-chaperone-mediated-autophagy
#18
Wenming Li, Jinqiu Zhu, Juan Dou, Hua She, Kai Tao, Haidong Xu, Qian Yang, Zixu Mao
Endoplasmic reticulum (ER) and lysosomes coordinate a network of key cellular processes including unfolded protein response (UPR) and autophagy in response to stress. How ER stress is signaled to lysosomes remains elusive. Here we find that ER disturbance activates chaperone-mediated autophagy (CMA). ER stressors lead to a PERK-dependent activation and recruitment of MKK4 to lysosomes, activating p38 MAPK at lysosomes. Lysosomal p38 MAPK directly phosphorylates the CMA receptor LAMP2A at T211 and T213, which causes its membrane accumulation and active conformational change, activating CMA...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29168286/comparative-proteomic-profiling-reveals-a-role-for-cisd2-in-skeletal-muscle-aging
#19
Yi-Long Huang, Zhao-Qing Shen, Chia-Yu Wu, Yuan-Chi Teng, Chen-Chung Liao, Cheng-Heng Kao, Liang-Kung Chen, Chao-Hsiung Lin, Ting-Fen Tsai
Skeletal muscle has emerged as one of the most important tissues involved in regulating systemic metabolism. The gastrocnemius is a powerful skeletal muscle composed of predominantly glycolytic fast-twitch fibers that are preferentially lost among old age. This decrease in gastrocnemius muscle mass is remarkable during aging; however, the underlying molecular mechanism is not fully understood. Strikingly, there is a ~70% decrease in Cisd2 protein, a key regulator of lifespan in mice and the disease gene for Wolfram syndrome 2 in humans, within the gastrocnemius after middle age among mice...
November 23, 2017: Aging Cell
https://www.readbyqxmd.com/read/29165698/nuclear-mrna-degradation-tunes-the-gain-of-the-unfolded-protein-response-in-saccharomyces-cerevisiae
#20
Debasish Sarkar, Sunirmal Paira, Biswadip Das
Unfolded protein response (UPR) is triggered by the accumulation of unfolded proteins in the endoplasmic reticulum (ER), which is accomplished by a dramatic induction of genes encoding ER chaperones. Activation of these genes involves their rapid transcription by Hac1p, encoded by the HAC1 precursor transcript harboring an intron and a bipartite element (3'-BE) in the 3'-UTR. ER stress facilitates intracellular targeting and recruitment of HAC1 pre-mRNA to Ire1p foci (requiring 3'-BE), leading to its non-spliceosomal splicing mediated by Ire1p/Rlg1p...
November 20, 2017: Nucleic Acids Research
keyword
keyword
29900
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"