Kun Guo, Wei Wang, Weiwei Fan, Zhiying Wang, Manli Zhu, Xiaohan Tang, Wenting Wu, Xue Yang, Xinghua Shao, Yue Sun, Wei Zhang, Xiaofang Li
The function of human Golgi antiapoptotic proteins (GAAPs) resembles that of BAX inhibitor-1, with apoptosis inhibition triggered by intrinsic and extrinsic stimuli. However, little is known about the function of GAAP-related proteins in plants. Here, we studied Arabidopsis GAAP1 and GAAP3 and found that they were localized on the cellular membrane, including the endoplasmic reticulum (ER) membrane. The function of GAAP1/GAAP3 in ER-stress response was tested, and results showed that single or double mutation in GAAP1 and GAAP3 reduced plant survival and enhanced cell death under ER stress...
2018: Frontiers in Plant Science