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Coronary artery disease

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https://www.readbyqxmd.com/read/28238413/genetic-variation-within-the-y-chromosome-is-not-associated-with-histological-characteristics-of-the-atherosclerotic-carotid-artery-or-aneurysmal-wall
#1
Saskia Haitjema, Jessica van Setten, James Eales, Sander W van der Laan, Ilaria Gandin, Jean-Paul P M de Vries, Gert J de Borst, Gerard Pasterkamp, Folkert W Asselbergs, Fadi J Charchar, James F Wilson, Saskia C A de Jager, Maciej Tomaszewski, Hester M den Ruijter
BACKGROUND AND AIMS: Haplogroup I, a common European paternal lineage of the Y chromosome, is associated with increased risk of coronary artery disease in British men. It is unclear whether this haplogroup or any other haplogroup on the Y chromosome is associated with histological characteristics of the diseased vessel wall in other vascular manifestations of cardiovascular diseases showing a male preponderance. METHODS: We examined Dutch men undergoing either carotid endarterectomy from the Athero-Express biobank (AE, n = 1217) or open aneurysm repair from the Aneurysm-Express biobank (AAA, n = 393)...
February 20, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28238270/effects-of-trimetazidine-on-interleukin-2-and-interleukin-8-concentrations-in-patients-with-coronary-artery-disease
#2
Aleksander Danikiewicz, Janusz Szkodziński, Bartosz Hudzik, Ilona Korzonek-Szlacheta, Mariusz Gasior, Barbara Zubelewicz-Szkodzińska
Trimetazidine (TMZ) exhibits metabolic and cardioprotective effects. The aim of this study was to access the effects of TMZ on IL-2 and IL-8 serum concentrations in 156 patients with stable coronary artery disease. They underwent treadmill exercise test (TET) before and after 3-month TMZ treatment. IL-2 and IL-8 concentrations were determined before and after each TET. Before treatment, TET didn't influence IL-2 concentrations, whereas IL-8 concentrations increased. TMZ treatment led to a decrease in IL-2 concentrations before TET, as well as it made the observed difference in IL-8 concentrations become statistically insignificant following the second TET...
February 26, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28238236/the-impact-of-gender-on-outcomes-following-transcatheter-aortic-valve-implantation-true-effect-or-bias
#3
Vasileios F Panoulas, Neil Ruparelia, Russel Franks, Sayan Sen, Ben Ariff, Nilesh Sutaria, Angela Frame, Petros Nihoyannopoulos, Iqbal S Malik, Ghada W Mikhail
Transcatheter aortic valve implantation (TAVI) is currently the treatment of choice for patients with severe aortic stenosis (AS) who are unsuitable for surgical aortic valve replacement (SAVR), and is an acceptable alternative for those at high and intermediate surgical risk. In published TAVI registries and meta-analyses, whilst women are significantly older they present with fewer comorbidities compared to men (including coronary artery disease, peripheral vascular disease, diabetes and chronic obstructive pulmonary disease)...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28238235/prevalence-and-impact-of-prosthesis-patient-mismatch-following-surgical-aortic-valve-replacement-for-pure-aortic-regurgitation
#4
Vincent Auffret, Pierre Voisine, Alexandre Cinq-Mars, Éric Charbonneau, Florent Le Ven, Sacha-Michelle Dubois-Sénéchal, Eduardo Brenna, François Dagenais, Michelle Dubois, Carine Ridard, Mario Sénéchal
BACKGROUND: Prosthesis-patient mismatch (PPM) is highly prevalent among patients undergoing aortic valve replacement (AVR) to treat aortic stenosis. Data regarding the prevalence and impact of PPM on left ventricular remodeling and outcomes in patients who have undergone surgical AVR to treat pure severe aortic regurgitation (AR) are, however, scarce. METHODS: A retrospective analysis was conducted of clinical and echocardiographic data acquired from 50 consecutive patients with pure severe AR, without evidence of significant coronary artery disease, who underwent AVR between 2004 and 2010 at the authors' institution...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28238152/myocardial-infarction-in-neonates-a-review-of-an-entity-with-significant-morbidity-and-mortality
#5
REVIEW
Koyelle Papneja, Anthony K Chan, Tapas K Mondal, Bosco Paes
Coronary artery disease is a global problem with high mortality rates and significant residual sequelae that affect long-term quality of life. Myocardial infarction (MI) in neonates is a recognized, uncommon entity, but the incidence and broad spectrum of the disease is unknown and likely underestimated due to limited reporting which in the majority is confined to acute ischemic events. The challenges involve clinical diagnosis which masquerades in the early phase as non-specific symptoms and signs that are commonly found in a host of neonatal disorders...
February 25, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28237549/il-37-increased-in-patients-with-acute-coronary-syndrome-and-associated-with-a-worse-clinical-outcome-after-st-segment-elevation-acute-myocardial-infarction
#6
Kun Liu, Qiang Tang, Xinyuan Zhu, Xinchun Yang
BACKGROUND: IL-37 emerges as a natural suppressor of inflammatory responses. The potential role of IL-37 in the pathology of atherosclerosis is unclear. The purpose of this study was to assess IL-37 profile in acute coronary syndrome (ACS) and the prognostic role of this cytokine in patients with ST-segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). METHODS: In a case-control study, we prospectively enrolled 216 patients undergoing the first coronary angiography, which consisted of 5 groups: normal (n=57), stable angina (SAP, n=36), unstable angina (UAP, n=42), non-STEMI (n=36), STEMI (n=45)...
February 22, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28237515/adiporon-an-adiponectin-receptor-agonist-attenuates-pdgf-induced-vsmc-proliferation-through-inhibition-of-mtor-signaling-independent-of-ampk-implications-toward-suppression-of-neointimal-hyperplasia
#7
Arwa Fairaq, Noha M Shawky, Islam Osman, Prahalathan Pichavaram, Lakshman Segar
Hypoadiponectinemia is associated with an increased risk of coronary artery disease. Although adiponectin replenishment mitigates neointimal hyperplasia and atherosclerosis in mouse models, adiponectin therapy has been hampered in a clinical setting due its large molecular size. Recent studies demonstrate that AdipoRon (a small-molecule adiponectin receptor agonist) improves glycemic control in type 2 diabetic mice and attenuates postischemic cardiac injury in adiponectin-deficient mice, in part, through activation of AMP-activated protein kinase (AMPK)...
February 22, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28237302/yiqifumai-powder-injection-attenuates-coronary-artery-ligation-induced-myocardial-remodeling-and-heart-failure-through-modulating-mapks-signaling-pathway
#8
Li-Zhi Pang, Ai-Chun Ju, Xian-Jie Zheng, Fang Li, Yun-Fei Song, Yan Zhao, Yuan-Feng Gu, Fei-Leng Chen, Chun-Hua Liu, Jin Qi, Zhen Gao, Jun-Ping Kou, Bo-Yang Yu
ETHNOPHARMACOLOGICAL RELEVANCE: YiQiFuMai Powder Injection (YQFM), a traditional Chinese medicine prescription re-developed based on Sheng-Mai-San, is a classical and traditional therapeutic for clinical heart failure (HF) and angina. However, its potential mechanism against HF remains unclear. AIM OF THE STUDY: The present study observes the therapeutic role of YQFM and mechanisms underlying its effects on coronary artery ligation (CAL)-induced myocardial remodeling (MR) and HF...
February 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28237083/association-of-the-fads-gene-cluster-with-coronary-artery-disease-and-plasma-lipid-concentrations-in-the-northern-chinese-han-population
#9
Yixia Wu, Lixin Zeng, Xueyan Chen, Yang Xu, Lin Ye, Ling Qin, Liping Chen, Lin Xie
We investigated the association of single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene cluster with coronary artery disease (CAD) in a case-control study and evaluated the possible influence of genetic variation on total cholesterol (TC) and triglyceride concentrations in the controls. In total, 497 CAD patients and 495 unrelated controls were genotyped for eight SNPs in the FADS gene cluster, and the blood lipid levels of subjects were measured. Three genetic models, including codominant, dominant and recessive, were used to analyze the genotypic relationship with CAD and plasma lipid levels...
February 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28236850/intermittent-hypoxia-as-a-means-to-improve-aerobic-capacity-in-type-2-diabetes
#10
R J Leone, S Lalande
Physical inactivity and a low maximal aerobic capacity (VO2max) strongly predict morbidity and mortality in patients with type 2 diabetes (T2D). Patients with T2D have a reduced VO2max when compared with healthy individuals of similar age, weight, and physical activity levels, and this lower aerobic capacity is usually attributed to a reduced oxygen delivery to the working muscles. The oxygen carrying capacity of the blood, as well as increases in cardiac output and blood flow, contribute to the delivery of oxygen to the active muscles during exercise...
March 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28236615/effects-of-music-therapy-on-endothelial-function-in-patients-with-coronary-artery-disease-participating-in-aerobic-exercise-therapy
#11
Marina Deljanin Ilic, Radmila F Pavlovic, Gordana Kocic, Dejan Simonovic, Gordana Lazarevic
Context • Pleasant music that evokes a positive emotional response may activate brain pathways of the insular cortex, central nucleus of the amygdala, and lateral hypothalamus, which are involved in the integration of emotional and ambient sensory input, with corresponding autonomic responses. Exercise training can improve endothelium-dependent vasodilatation, both in epicardial coronary vessels and in resistance vessels, for patients with coronary heart disease. Objective • The aim of the present study was to evaluate the effects on endothelial function when patients with stable coronary artery disease (CAD) listened to their favorite music...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28236568/evaluation-of-screening-for-myocardial-ischaemia-in-women-at-cardiovascular-risk
#12
Anne-Laure Madika, Patrick Devos, Pascal Delsart, Fanny Boudghène, Anne-Sophie Polge, Christophe Bauters, Claire Mounier-Vehier
BACKGROUND: Cardiovascular disease is the primary cause of death in women. Prevention, screening and diagnosis are generally implemented at later stages and less frequently than in men, and provision of treatment is not optimal in women. AIMS: To assess the relevance of targeted screening for myocardial ischaemia in women with multiple risk factors, and to identify which specific factors target women more effectively. METHODS: We undertook a prospective observational study with retrospective data collection based on a cohort of symptomatic or asymptomatic women with multiple cardiovascular risk factors...
February 21, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28236162/regression-and-complications-of-z-score-based-giant-aneurysms-in-a-dutch-cohort-of-kawasaki-disease-patients
#13
S M Dietz, I M Kuipers, J C D Koole, J M P J Breur, Z Fejzic, S Frerich, M Dalinghaus, A A W Roest, B A Hutten, T W Kuijpers
: Kawasaki disease (KD) is a pediatric vasculitis. Its main complication is the development of coronary artery aneurysms (CAA), with giant CAA at the end of the spectrum. We evaluated regression and event-free rates in a non-Asian cohort of patients with giant CAA using the current z-scores adjusted for body surface area instead of absolute diameters. KD patients with giant CAA (z-score ≥10) visiting our outpatient clinic between January 1999 and September 2015 were included. Patient characteristics and clinical details were extracted from medical records...
February 24, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28236020/impact-of-multi-vessel-versus-single-vessel-disease-on-outcomes-after-percutaneous-coronary-interventions-for-chronic-total-occlusions
#14
Aurel Toma, Barbara E Stähli, Michael Gick, Cathérine Gebhard, Thomas Nührenberg, Kambis Mashayekhi, Miroslaw Ferenc, Franz-Josef Neumann, Heinz Joachim Buettner
BACKGROUND: Successful chronic total occlusion (CTO) revascularization has been associated with prognostic benefits. Whether the extent of coronary artery disease interferes with these benefits has not been investigated yet. AIMS: We sought to compare the survival after percutaneous coronary intervention (PCI) for CTO between patients with multi- (MVD) and single-vessel disease (SVD). METHODS: A total of 2002 consecutive patients undergoing CTO PCI between 01/2005 and 12/2013 were identified and stratified according to the presence/absence of MVD...
February 24, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28235568/effect-of-oral-nitrates-on-all-cause-mortality-and-hospitalization-in-heart-failure-patients-with-reduced-ejection-fraction-a-propensity-matched-analysis
#15
Dilek Ural, Aysen Şimşek Kandemir, Kurtuluş Karaüzüm, Canan Baydemir, İrem Yılmaz Karaüzüm, Serdar Bozyel, Güliz Kozdağ, Ayşen Ağaçdiken Ağır
BACKGROUND: - Hydralazine-nitrates combination is recommended for systolic heart failure (HFrEF) patients who are symptomatic despite guideline directed medical therapy (GDMT). Use of nitrates alone for this indication is not well-established. This study aims to evaluate the effect of oral nitrates on all-cause mortality and hospitalization in HFrEF patients using GDMT. METHODS AND RESULTS: -Nitrates prescription at discharge and its association with all-cause mortality and HF hospitalization were examined in a propensity-matched analysis of 648 HFrEF patients followed-up for a median 56 months time...
February 21, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28234978/prognostic-value-of-dobutamine-stress-myocardial-perfusion-echocardiography-in-patients-with-known-or-suspected-coronary-artery-disease-and-normal-left-ventricular-function
#16
Angele A A Mattoso, Jeane M Tsutsui, Ingrid Kowatsch, Vitória Y L Cruz, João C N Sbano, Henrique B Ribeiro, Roberto Kalil Filho, Thomas R Porter, Wilson Mathias
OBJECTIVE: We sought to determine the prognostic value of qualitative and quantitative analysis obtained by real-time myocardial perfusion echocardiography (RTMPE) in patients with known or suspected coronary artery disease (CAD). BACKGROUND: Quantification of myocardial blood flow reserve (MBFR) in patients with CAD using RTMPE has been demonstrated to further improve accuracy over the analysis of wall motion (WM) and qualitative analysis of myocardial perfusion (QMP)...
2017: PloS One
https://www.readbyqxmd.com/read/28234671/rare-coding-variants-associated-with-blood-pressure-variation-in-15%C3%A2-914-individuals-of-african-ancestry
#17
Priyanka Nandakumar, Dongwon Lee, Melissa A Richard, Fasil Tekola-Ayele, Bamidele O Tayo, Erin Ware, Yun J Sung, Babatunde Salako, Adesola Ogunniyi, C Charles Gu, Megan L Grove, Myriam Fornage, Sharon Kardia, Charles Rotima, Richard S Cooper, Alanna C Morrison, Georg Ehret, Aravinda Chakravarti
OBJECTIVES: Hypertension is a major risk factor for all cardiovascular diseases, especially among African Americans. This study focuses on identifying specific blood pressure (BP) genes using 15 914 individuals of African ancestry from eight cohorts (Africa America Diabetes Mellitus, Atherosclerosis Risk in Communities Study, Coronary Artery Risk Development in young Adults, Genetics Network, Genetic Epidemiology Network of Arteriopathy, Howard University Family Study, Hypertension Genetic Epidemiology Network, and Loyola University Chicago Cohort) to further genetic findings in this population which has generally been underrepresented in BP studies...
February 22, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28234049/american-academy-of-asthma-allergy-immunology-membership-experience-with-venom-immunotherapy-in-chronic-medical-conditions-and-pregnancy-and-in-young-children
#18
Christopher W Calabria, David W Hauswirth, Matthew Rank, Lawrence Sher, Desiree Larenas-Linnemann
BACKGROUND: Few data exist regarding the use of venom immunotherapy (VIT) in specific high-risk chronic medical conditions and pregnancy, and in young children. METHODS: A Web-based survey was sent to American Academy of Asthma Allergy & Immunology members to explore their VIT experience in potential high-risk medical conditions and pregnancy, and in young children. Major problems were defined as "activation of underlying disease and/or VIT not well tolerated (systemic adverse events) and/or VIT discontinued for medical reasons...
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28233623/prediction-factors-of-recurrent-stroke-among-chinese-adults-using-retinal-vasculature-characteristics
#19
REVIEW
Yuanyuan Zhuo, Haibo Yu, Zhuoxin Yang, Benny Zee, Jack Lee, Lei Kuang
OBJECTIVE: To identify the characteristics of retinal vessels that are associated with recurrent cerebral infarction and to establish predictive model for recurrent cerebral infarction in further study. METHODS: Up to 196 patients with cerebral infarction were included in our study, including 137 patients with new onset cerebral infarction and 59 patients with recurrent cerebral infarction. Retinal vessel characteristics of all patients were analyzed and reported by an automated retinal image analysis system...
February 20, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28233536/impact-on-image-quality-and-radiation-dose-of-third-generation-dual-source-computed-tomography-of-the-coronary-arteries
#20
Georg Apfaltrer, Dieter H Szolar, Eric Wurzinger, Richard A P Takx, John W Nance, Anja Dutschke, Sebastian Tschauner, Christian Loewe, Helmut Ringl, Erich Sorantin, Paul Apfaltrer
The aim of this study was to assess the image quality (IQ) and radiation dose of third-generation dual-source computed tomography (CT) coronary angiography (cCTA) in comparison with 64-slice single-source CT. This retrospective study included 140 patients (73 men, mean age 62 ± 11 years) with low-to-intermediate probability of coronary artery disease who underwent either third-generation dual-source cCTA using prospectively electrocardiography-triggered high-pitch spiral acquisition (n = 70) (group 1) or retrospective electrocardiography-gated cCTA on a 64-slice CT system (n = 70) (group 2)...
January 25, 2017: American Journal of Cardiology
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