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Coronary artery disease

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https://www.readbyqxmd.com/read/29913468/clarithromycin-in-patients-with-coronary-artery-disease
#1
(no author information available yet)
No abstract text is available yet for this article.
May 21, 2018: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/29912879/polyclonal-human-antibodies-against-glycans-bearing-red-meat-derived-non-human-sialic-acid-n-glycolylneuraminic-acid-are-stable-reproducible-complex-and-vary-between-individuals-total-antibody-levels-are-associated-with-colorectal-cancer-risk
#2
Annie N Samraj, Kimberly A Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J Gregg, Sandra L Diaz, Sherilyn Sawyer, Xi Chen, Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki
BACKGROUND: N-glycolylneuraminic acid (Neu5Gc) is a non-human red-meat-derived sialic acid immunogenic to humans. Neu5Gc can be metabolically incorporated into glycan chains on human endothelial and epithelial surfaces. This represents the first example of a "xeno-autoantigen", against which circulating human "xeno-autoantibodies" can react. The resulting inflammation ("xenosialitis") has been demonstrated in human-like Neu5Gc-deficient mice and contributed to carcinoma progression via antibody-mediated inflammation...
2018: PloS One
https://www.readbyqxmd.com/read/29912783/impact-of-serum-lipoprotein-a-on-endothelium-dependent-coronary-vasomotor-response-assessed-by-intracoronary-acetylcholine-provocation
#3
Ahmed Mashaly, Seung-Woon Rha, Byoung G Choi, Man J Baek, Yang G Ryu, Se Y Choi, Jae K Byun, Kareem Abdelshafi, Yoonjee Park, Won Y Jang, Kim Woohyeun, Eun J Park, Jah Yeon Choi, Jin O Na, Cheol U Choi, Hong E Lim, Eung J Kim, Chang G Park, Hong S Seo
BACKGROUND: Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic vascular disease. However, there are limited data regarding the impact of Lp(a) levels on the incidence and severity of endothelium-dependent coronary vasomotor response. PATIENTS AND METHODS: A total of 2416 patients without significant coronary artery lesion (<50% stenosis) by coronary angiography and underwent acetylcholine (ACh) provocation test were enrolled and categorized according to their serum Lp(a) level into four quartile groups: less than 6...
June 16, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29912782/a-randomized-triple-blind-trial-of-cardiac-shock-wave-therapy-on-exercise-tolerance-and-symptoms-in-patients-with-stable-angina-pectoris
#4
Evgeny Shkolnik, Greta Burneikaite, Gabrielius Jakutis, Mikhail Scherbak, Gitana Zuoziene, Birute Petrauskiene, Ekaterina Trush, Yury Vasyuk, Aleksandras Laucevicius, Jelena Celutkiene
BACKGROUND: Despite major advances in managing coronary artery disease and continuous research on alternative techniques to enhance myocardial perfusion and reduce symptoms, coronary artery disease is still one of the leading causes of adult disability worldwide. Cardiac shock-wave therapy (CSWT) has shown promising results in the amelioration of myocardial ischemia in experimental studies; however, clinical results are limited to single-center, mostly uncontrolled and underpowered trials...
June 16, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29912365/tisan-estimating-tissue-specific-effects-of-coding-and-noncoding-variants
#5
Kévin Vervier, Jacob J Michaelson
Motivation: Model-based estimates of general deleteriousness, like CADD, DANN or PolyPhen, have become indispensable tools in the interpretation of genetic variants. However, these approaches say little about the tissues in which the effects of deleterious variants will be most meaningful. Tissue-specific annotations have been recently inferred for dozens of tissues/cell types from large collections of cross-tissue epigenomic data, and have demonstrated sensitivity in predicting affected tissues in complex traits...
April 18, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29912238/-a-unique-case-of-secondary-takotsubo-syndrome
#6
Luca Arcari, Luca Rosario Limite, Camillo Autore, Massimo Volpe, Maria Beatrice Musumeci
Takotsubo syndrome (TTS) is an acute cardiac syndrome characterized by transient systolic left ventricular dysfunction frequently preceded by stressful events. It typically affects postmenopausal women without angiographic evidence of obstructive coronary artery disease. We report here an uncommon occurrence of secondary TTS in a male with coronary artery disease after exogenous catecholamine administration and pacemaker implantation. This unexpected case suggests that, in such clinical scenario, a TTS diagnosis might be considered even in unsuspected individuals...
April 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29912225/-when-and-how-to-investigate-myocardial-viability-in-clinical-practice
#7
Elena Giulia Milano, Tobias Andreas Fuchs, Alice Niero, Estefania De Garate, Anna Baritussio, Chiara Bucciarelli-Ducci
The assessment of myocardial viability is a crucial step in the work-up of patients with coronary artery disease and left ventricular (LV) systolic dysfunction. Myocardial revascularization should be considered in patients with viable myocardium and LV systolic dysfunction, since this could improve LV function and outcomes.Noninvasive imaging plays a key role in the study of viability and different modalities are currently available, including cardiac magnetic resonance, stress echocardiography and nuclear imaging...
June 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29911119/the-association-between-nfkb1-94attg-ins-del-and-nfkb1a-826c-t-genetic-variations-and-coronary-artery-disease-risk
#8
Abbas Seidi, Sina Mirzaahmadi, Khalil Mahmoodi, Mohammad Soleiman-Soltanpour
Coronary artery disease (CAD) is considered as a chronic inflammatory disease initiated from early childhood. Nuclear factor κB (NF κB) and κB1A (NF κB1A) are the key regulators of inflammatory responses. The NFKB1 -94ATTG ins/del and NFKB1A -826C/T polymorphisms may contribute to the development of CAD. The aim of the present study was to investigate the association of these polymorphisms with the risk of CAD. The study population included 120 patients with angiographically confirmed CAD and 100 matched controls...
March 2018: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/29910582/management-of-hyperglycemia-during-and-in-the-immediate-follow-up-of-acute-coronary-syndrome
#9
REVIEW
Jamal El Ouazzani, Amine Ghalem, Ghizlane El Ouazzani, Nabila Ismaili, Noha El Ouafi
Diabetes is a serious, frequent, and insidious morbidity and mortality risk factor in patients with coronary artery disease. It has been shown that carbohydrate metabolism disorders are common in acute coronary syndromes (ACSs): 30-40% of patients have diabetes, 25-36% have an intolerance to carbohydrates, and only 30-40% have a normal carbohydrate profile. Hyperglycemia occurring either in diabetic or nondiabetic patients is strongly associated with a poor prognosis. It increases the extent of myocardial necrosis, and the risk of recurrence acute coronary syndrome and hemodynamic complications, particularly heart failure and cardiogenic shock, reflecting the importance of optimal management of glucose metabolism abnormalities...
April 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29910104/multivessel-coronary-artery-disease-and-poor-left-ventricle-function-it-is-consistent-and-clear-coronary-artery-bypass-grafting-wins-again
#10
EDITORIAL
Saina Attaran, William S Weintraub, Vinod H Thourani
No abstract text is available yet for this article.
May 28, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29910052/incidence-timing-and-type-of-first-and-recurrent-ischemic-events-in-patients-with-and-without-peripheral-artery-disease-after-an-acute-coronary-syndrome
#11
Taku Inohara, Karen Pieper, Daniel M Wojdyla, Manesh R Patel, William Schuyler Jones, Pierluigi Tricoci, Kenneth W Mahaffey, Stefan K James, John H Alexander, Renato D Lopes, Lars Wallentin, Erik Magnus Ohman, Matthew T Roe, Sreekanth Vemulapalli
BACKGROUND: Patients with peripheral artery disease (PAD) are known to have an increased risk of ischemic cardiovascular events. However, the influence of concomitant PAD on first and subsequent recurrent ischemic events after an acute coronary syndrome (ACS) remains poorly characterized. METHODS: We analyzed the combined data set from 4 randomized trials (PLATO, APPRAISE-2, TRA-CER, and TRILOGY ACS) in ACS for a follow-up length of 1 year. Using multivariable regression, we examined the association between PAD and major adverse cardiovascular events, a composite of cardiovascular death, myocardial infarction, and stroke...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29909404/aortic-arch-width-and-cardiovascular-disease-in-men-and-women-in-the-community
#12
Michael L Chuang, Philimon N Gona, Saadia Qazi, Rebecca M Musgrave, Caroline S Fox, Joseph M Massaro, Udo Hoffmann, Christopher J O'Donnell
BACKGROUND: We sought to determine whether increased aortic arch width (AAW) adds to standard Framingham risk factors and coronary artery calcium (CAC) for prediction of incident adverse cardiovascular disease (CVD) events in community-dwelling adults. METHODS AND RESULTS: A total of 3026 Framingham Heart Study Offspring and Third Generation cohort participants underwent noncontrast multidetector computed tomography from 2002 to 2005 to quantify CAC. We measured AAW as the distance between the centroids of the ascending and descending thoracic aorta, at the level of main pulmonary artery bifurcation or the right pulmonary artery...
June 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29909113/coronary-computed-tomography-angiography-versus-stress-echocardiography-in-acute-chest-pain-a-randomized-controlled-trial
#13
Jeffrey M Levsky, Linda B Haramati, Daniel M Spevack, Mark A Menegus, Terence Chen, Sarah Mizrachi, Durline Brown-Manhertz, Samantha Selesny, Rikah Lerer, Deborah J White, Jonathan N Tobin, Cynthia C Taub, Mario J Garcia
OBJECTIVES: This study sought to compare early emergency department (ED) use of coronary computed tomography angiography (CTA) and stress echocardiography (SE) head-to-head. BACKGROUND: Coronary CTA has been promoted as the early ED chest pain triage imaging method of choice, whereas SE is often overlooked in this setting and involves no ionizing radiation. METHODS: The authors randomized 400 consecutive low- to intermediate-risk ED acute chest pain patients without known coronary artery disease and a negative initial serum troponin level to immediate coronary CTA (n = 201) or SE (n = 199)...
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29909109/effects-of-statins-on-coronary-atherosclerotic-plaques-the-paradigm-progression-of-atherosclerotic-plaque-determined-by-computed-tomographic-angiography-imaging-study
#14
Sang-Eun Lee, Hyuk-Jae Chang, Ji Min Sung, Hyung-Bok Park, Ran Heo, Asim Rizvi, Fay Y Lin, Amit Kumar, Martin Hadamitzky, Yong Jin Kim, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J Budoff, Ilan Gottlieb, Byoung Kwon Lee, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Jonathon A Leipsic, Sanghoon Shin, Jung Hyun Choi, Kavitha Chinnaiyan, Gilbert Raff, Renu Virmani, Habib Samady, Peter H Stone, Daniel S Berman, Jagat Narula, Leslee J Shaw, Jeroen J Bax, James K Min
OBJECTIVES: This study sought to describe the impact of statins on individual coronary atherosclerotic plaques. BACKGROUND: Although statins reduce the risk of major adverse cardiovascular events, their long-term effects on coronary atherosclerosis remain unclear. METHODS: We performed a prospective, multinational study consisting of a registry of consecutive patients without history of coronary artery disease who underwent serial coronary computed tomography angiography at an interscan interval of ≥2 years...
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29909103/prrospective-comparison-of-ffr-derived-from-coronary-ct-angiography-with-spect-perfusion-imaging-in-stable-coronary-artery-disease-the-reassess-study
#15
Niels Peter Rønnow Sand, Karsten Tange Veien, Søren Steen Nielsen, Bjarne Linde Nørgaard, Pia Larsen, Allan Johansen, Søren Hess, Lone Deibjerg, Majed Husain, Anders Junker, Kristian Korsgaard Thomsen, Allan Rohold, Lisette Okkels Jensen
OBJECTIVES: This study sought to compare the per-patient diagnostic performance of coronary computed tomography angiography (CTA)-derived fractional flow reserve (FFRCT ) with that of single-photon emission computed tomography (SPECT), using a fractional flow reserve (FFR) value of ≤0.80 as the reference for diagnosing at least 1 hemodynamically significant stenosis in a head-to-head comparison of patients with intermediate coronary stenosis as determined by coronary CTA. BACKGROUND: No previous study has prospectively compared the diagnostic performance of FFRCT and myocardial perfusion imaging by SPECT in symptomatic patients with intermediate range coronary artery disease (CAD)...
June 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29908999/the-roles-of-pai-1-gene-polymorphisms-in-atherosclerotic-diseases-a-systematic-review-and-meta-analysis-involving-149-908-subjects
#16
Yu Liu, Jianxin Cheng, Xiangyi Guo, Jingjing Mo, Beibei Gao, Huiyuan Zhou, Yixin Wu, Zhijuan Li
BACKGROUND: The roles of plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in atherosclerotic diseases were intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between PAI-1 genetic variations and atherosclerosis. METHODS: Eligible studies were searched in PubMed, Medline, Embase and Web of Science. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess relationship between PAI-1 polymorphisms and atherosclerotic diseases...
June 14, 2018: Gene
https://www.readbyqxmd.com/read/29908974/severe-infrarenal-atheroma-load-in-open-aortic-aneurysm-repair-is-not-a-risk-factor-for-postoperative-acute-kidney-injury
#17
S Ooms, B Nemeth, J J Wever, B Knippenberg, H van Overhagen, R G Statius van Eps
OBJECTIVES: Acute Kidney Injury (AKI) after open aortic repair is subject to multiple patient- and operation-related variables. Hostile neck morphology in open aneurysm repair is thought to contribute to this AKI risk post-operatively. The aim of this study was to evaluate if large neck atheroma is a possible risk factor in the postoperative development of AKI. METHODS: Retrospectively 137 patients were evaluated for neck atheroma and AKI incidence. Atheroma load measurements were performed by two different techniques...
June 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29908956/complement-activation-in-acute-myocardial-infarction-an-early-marker-of-inflammation-and-tissue-injury
#18
Lorena Bavia, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Miguel Ibraim Abboud Hanna Sobrinho, Renato Mitsunori Nisihara, Iara Jose de Messias-Reason
BACKGROUND: Acute myocardial infarction (AMI) is a potentially fatal condition, being a major cause of death worldwide. Ischemia suffered during AMI causes tissue damage, leading to an inflammatory process. Moreover, myocardial injury can generate damage-associated molecular patterns that activate pattern recognition molecules including some complement proteins. METHODS: Here we investigated products of complement activation, C3d and soluble C5b9 (sC5b9), as potential biomarkers for myocardial injury and inflammation, as well as serum cytokines (IL-6 and TNF-alpha), alpha-1-acid glycoprotein (AGP), and classical markers of myocardial necrosis (creatine kinase, creatine kinase-MB isoform, myoglobin and troponin-I) in a longitudinal study of patients with AMI (from admission, 6 h and 12 h post admission, and at discharge from hospital)...
June 14, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29908836/dopps-data-suggest-a-possible-survival-benefit-of-renin-angiotensin-aldosterone-system-inhibitors-and-other-antihypertensive-medications-for-hemodialysis-patients
#19
Angelo Karaboyas, Hairong Xu, Hal Morgenstern, Francesco Locatelli, Michel Jadoul, Kosaku Nitta, Indranil Dasgupta, Francesca Tentori, Friedrich K Port, Bruce M Robinson
The benefits of renin angiotensin-aldosterone system inhibitors (RAASi) are well-established in the general population, particularly among those with diabetes, congestive heart failure (CHF), or coronary artery disease (CAD). However, conflicting evidence from trials and concerns about hyperkalemia limit RAASi use in hemodialysis patients, relative to other antihypertensive agents, including beta blockers and calcium channel blockers. Therefore, we investigated prescription patterns and associations with mortality for RAASi and other antihypertensive agents using data from the international Dialysis Outcomes and Practice Patterns Study (DOPPS)...
June 13, 2018: Kidney International
https://www.readbyqxmd.com/read/29908618/hormonal-management-for-transfeminine-individuals
#20
REVIEW
Jessica Abramowitz, Vin Tangpricha
Transfeminine individuals are treated with estradiol and anti-androgen agents to transition to a more feminine appearance. The physical changes that occur with estradiol therapy include breast development, body fat redistribution, and decreased muscle mass. Transfeminine treatment regimens require monitoring and dose adjustments to achieve appropriate physiologic targets to enhance feminization and decrease risk of adverse outcomes. Adverse effects associated with estradiol use include thromboembolic disease, macroprolactinoma, breast cancer, coronary artery disease, cerebrovascular disease, cholelithiasis, and hypertriglyceridemia...
July 2018: Clinics in Plastic Surgery
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