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https://www.readbyqxmd.com/read/29471406/multiobjective-multifactor-dimensionality-reduction-to-detect-snp-snp-interactions
#1
Cheng-Hong Yang, Li-Yeh Chuang, Yu-Da Lin
Motivation: Single-nucleotide polymorphism (SNP)-SNP interactions (SSIs) are popular markers for understanding disease susceptibility. Multifactor dimensionality reduction (MDR) can successfully detect considerable SSIs. Currently, MDR-based methods mainly adopt a single-objective function (a single measure based on contingency tables) to detect SSIs. However, generally, a single-measure function might not yield favorable results due to potential model preferences and disease complexities...
February 19, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29471259/functional-genomics-and-assays-of-regulatory-activity-detect-mechanisms-at-loci-for-lipid-traits-and-coronary-artery-disease
#2
REVIEW
Tamara S Roman, Karen L Mohlke
Many genome-wide association studies (GWAS) have identified signals located in non-coding regions, and an increasing number of functional genomics annotations of regulatory elements and assays of regulatory activity have been used to investigate mechanisms. Genome-wide datasets that characterize chromatin structure help detect potential regulatory elements. Assays to experimentally assess candidate variants include transcriptional reporter assays, and recently, massively parallel reporter assays (MPRAs). Additionally, the effect of candidate regulatory elements and variants on gene expression and function can be evaluated using genomic editing with the CRISPR-Cas9 technology...
February 19, 2018: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/29470616/automated-spect-analysis-compared-with-expert-visual-scoring-for-the-detection-of-ffr-defined-coronary-artery-disease
#3
R S Driessen, P G Raijmakers, I Danad, W J Stuijfzand, S P Schumacher, J A Leipsic, J K Min, J Knuuti, A A Lammertsma, A C van Rossum, N van Royen, S R Underwood, P Knaapen
PURPOSE: Traditionally, interpretation of myocardial perfusion imaging (MPI) is based on visual assessment. Computer-based automated analysis might be a simple alternative obviating the need for extensive reading experience. Therefore, the aim of the present study was to compare the diagnostic performance of automated analysis with that of expert visual reading for the detection of obstructive coronary artery disease (CAD). METHODS: 206 Patients (64% men, age 58...
February 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29469026/effect-of-nutritional-status-on-mortality-in-patients-undergoing-coronary-artery-bypass-grafting
#4
Muhammed Keskin, Göktük İpek, Mustafa Aldağ, Servet Altay, Mert İlker Hayıroğlu, Edibe Betül Börklü, Duygu İnan, Ömer Kozan
OBJECTIVES: The prognostic effects of poor nutritional status and cardiac cachexia on coronary artery disease (CAD) are not clearly understood. A well-accepted nutritional status parameter, the prognostic nutritional index (PNI), which was first demonstrated to be valuable in patients with cancer and those undergoing gastrointestinal surgery, was introduced to patients requiring coronary artery bypass grafting (CABG). The aim of the present study was to evaluate the prognostic value of PNI in patients with CAD undergoing CABG...
December 7, 2017: Nutrition
https://www.readbyqxmd.com/read/29468911/reality-of-obesity-paradox-results-of-percutaneous-coronary-intervention-in-middle-eastern-patients
#5
Mohamad Jarrah, Ayman J Hammoudeh, Yousef Khader, Ramzi Tabbalat, Eyas Al-Mousa, Osama Okkeh, Imad A Alhaddad, Loai Issa Tawalbeh, Issa M Hweidi
Objective The aim of this study was to assess the baseline clinical characteristics, coronary angiographic features, and adverse cardiovascular events during hospitalization and at 1 year of follow-up in obese patients compared with overweight and normal/underweight patients. Methods A prospective, multicenter study of consecutive patients undergoing percutaneous coronary intervention was performed. Results Of 2425 enrolled patients, 699 (28.8%) were obese, 1178 (48.6%) were overweight, and 548 (22.6%) were normal/underweight...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29468730/comparison-of-three-treatment-strategies-for-patients-with-triple-vessel-coronary-disease-and-left-ventricular-dysfunction
#6
Lin Jiang, Lianjun Xu, Lei Song, Zhan Gao, Jian Tian, Kai Sun, Hongwei Yu, Bo Xu, Lei Song, Jinqing Yuan
INTRODUCTION: Current guidelines recommend coronary artery bypass grafting (CABG) for patients with multivessel coronary disease and left ventricular (LV) dysfunction. However, some patients undergo percutaneous coronary intervention (PCI) or solely medical therapy (MT) in actual practice. The comparison of long-term outcomes of these three treatment strategies in real world is unclear. METHODS: A total of 699 consecutive patients in a single centre from 2004 to 2011 who had TVD and LV ejection fraction ≤40%, no prior PCI or CABG and had completed a median 6...
February 21, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29467588/pulmonary-arterial-enlargement-is-associated-with-acute-chest-pain-in-patients-without-obstructive-coronary-artery-disease
#7
Narasa Madam, Wassim Mosleh, Natdanai Punnanithinont, Andres Carmona-Rubio, Zaid H Said, Umesh C Sharma
Background: Pulmonary hypertension (PH) is an underdiagnosed cause for chest pain in patients without significant coronary artery disease (CAD). Studies showed that enlarged pulmonary arterial (PA) and right ventricular chamber sizes correlate with the severity of PH. Therefore, we studied the association between chest pain, right ventricular dimensions (RVDs), and PA size on coronary coronary tomographic angiography (CCTA). Methods: The CCTA of 87 patients presenting with chest pain without evidence of obstructive CAD was examined...
2018: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/29467545/vulnerable-atherosclerotic-plaque-review-of-current-concepts-and-advanced-imaging
#8
Miloslav Spacek, David Zemanek, Martin Hutyra, Martin Sluka, Milos Taborsky
Atherosclerosis is the most common cause of both carotid and coronary steno-occlusive disease. Rupture of an atherosclerotic plaque may lead to the formation of an overlying thrombosis resulting in complete arterial occlusion or downstream embolism. Clinically, this may manifest as a stroke or acute myocardial infarction, the overall leading causes of mortality and disability in developed countries. In this article, we summarize current concepts of the development of vulnerable plaque and provide an overview of commonly used imaging methods that may suggest/indicate atherosclerotic plaque vulnerability...
February 21, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29467471/network-analysis-of-coronary-artery-disease-risk-genes-elucidates-disease-mechanisms-and-druggable-targets
#9
Harri Lempiäinen, Ingrid Brænne, Tom Michoel, Vinicius Tragante, Baiba Vilne, Tom R Webb, Theodosios Kyriakou, Johannes Eichner, Lingyao Zeng, Christina Willenborg, Oscar Franzen, Arno Ruusalepp, Anuj Goel, Sander W van der Laan, Claudia Biegert, Stephen Hamby, Husain A Talukdar, Hassan Foroughi Asl, Gerard Pasterkamp, Hugh Watkins, Nilesh J Samani, Timo Wittenberger, Jeanette Erdmann, Heribert Schunkert, Folkert W Asselbergs, Johan L M Björkegren
Genome-wide association studies (GWAS) have identified over two hundred chromosomal loci that modulate risk of coronary artery disease (CAD). The genes affected by variants at these loci are largely unknown and an untapped resource to improve our understanding of CAD pathophysiology and identify potential therapeutic targets. Here, we prioritized 68 genes as the most likely causal genes at genome-wide significant loci identified by GWAS of CAD and examined their regulatory roles in 286 metabolic and vascular tissue gene-protein sub-networks ("modules")...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467161/outcomes-of-non-invasive-diagnostic-modalities-for-the-detection-of-coronary-artery-disease-network-meta-analysis-of-diagnostic-randomised-controlled-trials
#10
George Cm Siontis, Dimitris Mavridis, John P Greenwood, Bernadette Coles, Adriani Nikolakopoulou, Peter Jüni, Georgia Salanti, Stephan Windecker
OBJECTIVE: To evaluate differences in downstream testing, coronary revascularisation, and clinical outcomes following non-invasive diagnostic modalities used to detect coronary artery disease. DESIGN: Systematic review and network meta-analysis. DATA SOURCES: Medline, Medline in process, Embase, Cochrane Library for clinical trials, PubMed, Web of Science, SCOPUS, WHO International Clinical Trials Registry Platform, and Clinicaltrials.gov...
February 21, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29467150/high-sensitivity-troponin-i-levels-and-coronary-artery-disease-severity-progression-and-long-term-outcomes
#11
Ayman Samman Tahhan, Pratik Sandesara, Salim S Hayek, Muhammad Hammadah, Ayman Alkhoder, Heval M Kelli, Matthew Topel, Wesley T O'Neal, Nima Ghasemzadeh, Yi-An Ko, Mohamad Mazen Gafeer, Naser Abdelhadi, Fahad Choudhary, Keyur Patel, Agim Beshiri, Gillian Murtagh, Jonathan Kim, Peter Wilson, Leslee Shaw, Viola Vaccarino, Stephen E Epstein, Laurence Sperling, Arshed A Quyyumi
BACKGROUND: The associations between high-sensitivity troponin I (hsTnI) levels and coronary artery disease (CAD) severity and progression remain unclear. We investigated whether there is an association between hsTnI and angiographic severity and progression of CAD and whether the predictive value of hsTnI level for incident cardiovascular outcomes is independent of CAD severity. METHODS AND RESULTS: In 3087 patients (aged 63±12 years, 64% men) undergoing cardiac catheterization without evidence of acute myocardial infarction, the severity of CAD was calculated by the number of major coronary arteries with ≥50% stenosis and the Gensini score...
February 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29467048/pregnancy-associated-spontaneous-coronary-artery-dissection-pascad-an-etiology-for-chest-pain-in-the-young-peripartum-patient
#12
Richard Lee, David Carr
Cardiac emergencies in pregnancy and the postpartum period are rare but often life-threatening. An emergency physician's differential diagnosis for chest pain in the peripartum patient often includes serious etiologies such as pulmonary embolism or myocardial infarction (MI). A lesser-known but important consideration on the differential for MI is that of a spontaneous coronary artery dissection (SCAD). SCAD is defined as an intramural hematoma within the coronary artery that compresses the true lumen. Expansion by increased pressures may lead to subsequent myocardial ischemia and infarction...
February 22, 2018: CJEM
https://www.readbyqxmd.com/read/29466965/neutropenia-after-intravenous-immunoglobulin-therapy-is-associated-with-coronary-artery-lesions-in-children-with-kawasaki-disease-a-case-control-study
#13
Zhenquan Wang, Fengfeng Weng, Chen Li, Hongying Shi, Zhangke Tang, Huixian Qiu, Yue'e He, Rongzhou Wu, Maoping Chu
BACKGROUND: To evaluate differences in laboratory parameters, clinical presentation, and incidence of coronary artery lesions (CAL) between children with neutropenic and non-neutropenic Kawasaki disease (KD). METHODS: All consecutive KD patients that presented to the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University in Wenzhou, China between January 2005 and December 2015 were included in this study. Patients were divided into two groups (KD with neutropenia (NKD) and KD without neutropenia (NNKD)) based on whether or not they developed neutropenia during the course of treatment...
February 21, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29466206/-carotid-plaque-instability-in-patients-with-acute-coronary-syndrome-as-assessed-by-ultrasound-duplex-scanning
#14
O A Pogorelova, M I Tripoten, D A Guchaeva, R M Shahnovich, M Y Ruda, T V Balakhonova
AIM: to study carotid plaques structure in patients with acute coronary syndrome by ultrasound duplex scanning. MATERIALS AND METHODS: We included in this study143 patients with acute coronary syndrome (ACS) aged 32-83 years and 28 patients with documented coronary heart disease (CHD) aged 46-83 years. Duplex scanning of carotid arteries was carried out with Philips iU22 ultrasound system and L9-3 linear array transducer. Atherosclerotic plaques in CCA, CCA bifurcation, and ICA from right and left side were investigated...
December 2017: Kardiologiia
https://www.readbyqxmd.com/read/29466175/-giant-aneurysms-in-coronary-arteries-of-a-young-woman
#15
L N Ilyina, E E Vlasova, V V Kukharchuk, A A Shiryaev, E V Merkulov, D M Galyautdinov, V P Vasiliev, P P Malyshev, E V Dzybinskaya, P V Chumachenko, M A Aphanasyev, R S Akchurin
Coronary arteries aneurysms with their thrombotic occlusion are known to be detected in young patients who have suffered Kawasaki disease in childhood. The other vascular beds are usually not involved. In the literature one can find not enough information regarding diagnostics of this pathology, as well as no specific treatment algorithm. We present here a clinical case of re-emergence of giant aneurysms of coronary arteries in the young female patient with subsequent immuno-histological confirmation of previous Kawasaki disease...
January 2018: Kardiologiia
https://www.readbyqxmd.com/read/29465541/abnormal-glucose-regulation-in-chinese-patients-with-coronary-artery-disease-a-cross-sectional-study-erratum
#16
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465497/effects-of-%C3%AE-blockers-on-maximal-heart-rate-prediction-equations-in-a-cardiac-population
#17
Elizabeth Godlasky, Trisha Hoffman, Sonya Weber-Peters, Richard Bradford, Nathan Miller, Allen R Kunselman, Mary E J Lott
PURPOSE: To derive specific maximal heart rate (HRmax) prediction equations for a coronary artery disease (CAD) population based upon status of β-blocker (BB) therapy and to compare these to prior HRmax equations (Fox and Brawner-specific for CAD). METHODS: We retrospectively reviewed stress echocardiogram treadmill tests in patients with CAD, dividing subjects into 3 groups based upon BB use on test day: not prescribed BB therapy (no BB group; n = 110); held for 12 to 24 hr prior (held BB group; n = 155); and continued taking (took BB group; n = 72)...
March 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29465434/the-five-year-clinical-and-angiographic-follow-up-outcomes-of-intracoronary-transfusion-of-circulation-derived-cd34-cells-for-patients-with-end-stage-diffuse-coronary-artery-disease-unsuitable-for-coronary-intervention-phase-i-clinical-trial
#18
Pei-Hsun Sung, Fan-Yen Lee, Meng-Shen Tong, John Y Chiang, Sung-Nan Pei, Ming-Chun Ma, Yi-Chen Li, Yung-Lung Chen, Chiung-Jen Wu, Jiunn-Jye Sheu, Mel S Lee, Hon-Kan Yip
OBJECTIVES: This study investigated the clinical and angiographic long-term outcomes of intracoronary transfusion of circulation-derived CD34+ cells for patients with end-stage diffuse coronary artery disease unsuitable for coronary intervention. DESIGN AND SETTING: A single-center prospective randomized double-blinded phase I clinical trial. Thirty-eight patients undergoing CD34+ cell therapy were allocated into groups 1 (1.0 × 10 cells/each vessel; n = 18) and 2 (3...
February 19, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29465004/insulin-resistance-in-an-animal-model-of-polycystic-ovary-disease-is-aggravated-by-vitamin-d-deficiency-vascular-consequences
#19
Leila Hadjadj, Szabolcs Várbíró, Eszter Mária Horváth, Anna Monori-Kiss, Éva Pál, Gellért Balázs Karvaly, Andrea Heinzlmann, Attila Magyar, István Szabó, Réka Eszter Sziva, Zoltán Benyó, Mariann Buday, György László Nádasy
Hyperandrogenic state in females is accompanied with metabolic syndrome, insulin resistance and vascular pathologies. A total of 67%-85% of hyperandrogenic women suffer also from vitamin D deficiency. We aimed to check a potential interplay between hyperandrogenism and vitamin D deficiency in producing insulin resistance and effects on coronary resistance arteries. Adolescent female rats were divided into four groups, 11-12 animals in each. Transdermal testosterone-treated and vehicle-treated animals were kept either on vitamin D-deficient or on vitamin D-supplemented diet for 8 weeks...
February 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29464786/polymer-free-drug-eluting-stents-for-coronary-artery-disease
#20
REVIEW
Moritz Baquet, David Jochheim, Julinda Mehilli
Polymer-free drug-eluting stents (PF-DES) were designed with the expectation of avoiding late restenosis and thrombosis related to the polymer used in traditional DES platforms. Furthermore, due to similarities with bare metal stents after drug elution, PF-DES has been considered as particularly suitable for patients at high bleeding risk. A variety of PF-DES platforms have been clinically tested. Despite their theoretical advantages, PF platforms showed comparable clinical outcomes with modern permanent- or biodegradable polymer-based DES up to 5 years after implantation...
February 20, 2018: Journal of Interventional Cardiology
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