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https://www.readbyqxmd.com/read/27924186/treatment-of-chronic-hepatitis-c-infection-with-sofosbuvir-based-regimens-in-a-commercially-insured-patient-population
#1
John Barron, Yiqiong Xie, Sze-Jung Wu, Jeff White, Joseph Singer, Bernard Tulsi, Alan Rosenberg
BACKGROUND: The response to treatment with direct-acting antiviral agents in patients with chronic hepatitis C virus (HCV) is not well-characterized in the real-world setting. OBJECTIVE: To describe patients' response to 3 sofosbuvir-based treatment regimens among commercially insured patients with chronic HCV. METHODS: In this observational study, we identified patients with HCV who started sofosbuvir treatment with 1 of 3 sofosbuvir-based regimens between December 1, 2013, and April 30, 2014, in the HealthCore Integrated Research Database, a large managed care repository...
September 2016: American Health & Drug Benefits
https://www.readbyqxmd.com/read/27923923/antiviral-innate-immune-response-interferes-with-the-formation-of-replication-associated-membrane-structures-induced-by-a-positive-strand-rna-virus
#2
Diede Oudshoorn, Barbara van der Hoeven, Ronald W A L Limpens, Corrine Beugeling, Eric J Snijder, Montserrat Bárcena, Marjolein Kikkert
: Infection with nidoviruses like corona- and arteriviruses induces a reticulovesicular network of interconnected endoplasmic reticulum (ER)-derived double-membrane vesicles (DMVs) and other membrane structures. This network is thought to accommodate the viral replication machinery and protect it from innate immune detection. We hypothesized that the innate immune response has tools to counteract the formation of these virus-induced replication organelles in order to inhibit virus replication...
December 6, 2016: MBio
https://www.readbyqxmd.com/read/27920363/detection-of-imprinting-effects-for-qualitative-traits-on-x-chromosome-based-on-nuclear-families
#3
Ji-Yuan Zhou, Xiao-Ping You, Ran Yang, Wing Kam Fung
Methods for detecting imprinting effects have been developed primarily for autosomal markers. However, no method is available in the literature to test for imprinting effects on X chromosome. Therefore, it is necessary to suggest methods for detecting such imprinting effects. In this article, the parental-asymmetry test on X chromosome (XPAT) is first developed to test for imprinting for qualitative traits in the presence of association, based on family trios each with both parents and their affected daughter...
December 5, 2016: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/27918649/big-data-from-small-samples-informatics-of-next-generation-sequencing-in-cytopathology
#4
REVIEW
Sinchita Roy-Chowdhuri, Somak Roy, Sara E Monaco, Mark J Routbort, Liron Pantanowitz
The rapid adoption of next-generation sequencing (NGS) in clinical molecular laboratories has redefined the practice of cytopathology. Instead of simply being used as a diagnostic tool, cytopathology has evolved into a practice providing important genomic information that guides clinical management. The recent emphasis on maximizing limited-volume cytology samples for ancillary molecular studies, including NGS, requires cytopathologists not only to be more involved in specimen collection and processing techniques but also to be aware of downstream testing and informatics issues...
December 5, 2016: Cancer
https://www.readbyqxmd.com/read/27917167/potential-for-sulfate-reduction-in-mangrove-forest-soils-comparison-between-two-dominant-species-of-the-americas
#5
Melike Balk, Joost A Keuskamp, Hendrikus J Laanbroek
Avicennia and Rhizophora are globally occurring mangrove genera with different traits that place them in different parts of the intertidal zone. It is generally accepted that the oxidizing capacity of Avicennia roots is larger than that of Rhizophora roots, which initiates more reduced conditions in the soil below the latter genus. We hypothesize that the more reduced conditions beneath Rhizophora stands lead to more active sulfate-reducing microbial communities compared to Avicennia stands. To test this hypothesis, we measured sulfate reduction traits in soil samples collected from neighboring Avicennia germinans and Rhizophora mangle stands at three different locations in southern Florida...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27917018/modeling-confidence-and-response-time-in-associative-recognition
#6
Chelsea Voskuilen, Roger Ratcliff
Research examining models of memory has focused on differences in the shapes of ROC curves across tasks and has used these differences to argue for and against the existence of multiple memory processes. ROC functions are usually obtained from confidence judgments, but the reaction times associated with these judgments are rarely considered. The RTCON2 diffusion model for confidence judgments has previously been applied to data from an item recognition paradigm. It provided an alternative explanation for the shape of the z-ROC function based on how subjects set their response boundaries and these settings are also constrained by reaction times...
January 2016: Journal of Memory and Language
https://www.readbyqxmd.com/read/27910574/the-development-of-an-improved-streak-tube-for-fusion-diagnostics
#7
J R Howorth, J S Milnes, Y Fisher, A Jadwin, R Boni, P A Jaanimagi
The fusion diagnostic community, including the National Ignition Facility, the Laboratory for Laser Energetics, Megajoule in France, and others require optical recording instruments with precise time resolution covering a dynamic range of many orders of magnitude. In 2012, LLE, Photek, and Sydor Instruments embarked on the re-design of an improved streak tube for fusion diagnostics. As a baseline we started with the Photek ST-Y streak tube which is a member of the RCA design dating back to 1957, because the tube body can accommodate a 35 mm long photocathode, and consequently more fibre coupled diagnostic channels than smaller designs...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910561/orientation-free-and-differentially-pumped-addition-of-a-low-flux-reactive-gas-beam-to-a-surface-analysis-system
#8
Colin Harthcock, Abdolreza Jahanbekam, Jeremy R Eskelsen, David Y Lee
We describe an example of a piecewise gas chamber that can be customized to incorporate a low flux of gas-phase radicals with an existing surface analysis chamber for in situ and stepwise gas-surface interaction experiments without any constraint in orientation. The piecewise nature of this gas chamber provides complete angular freedom and easy alignment and does not require any modification of the existing surface analysis chamber. In addition, the entire gas-surface system is readily differentially pumped with the surface chamber kept under ultra-high-vacuum during the gas-surface measurements...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908176/activity-cross-calibration-of-unsealed-radionuclides-utilizing-a-portable-ion-chamber
#9
Hans-Sonke Jans
PURPOSE: To present and evaluate an ion chamber-based method for the cross-calibration between sites of activity measurements of unsealed radionuclides. Notably, the method allows direct comparison of short lived (i.e., clinically used) radioisotopes and the cross-calibration of radionuclide activity meters (also known as "dose calibrators"). METHODS: A portable ion chamber has been designed which is easily shipped between sites, e.g., between a standards laboratory and a nuclear medicine department...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27899660/cebs-a-comprehensive-annotated-database-of-toxicological-data
#10
Isabel A Lea, Hui Gong, Anand Paleja, Asif Rashid, Jennifer Fostel
The Chemical Effects in Biological Systems database (CEBS) is a comprehensive and unique toxicology resource that compiles individual and summary animal data from the National Toxicology Program (NTP) testing program and other depositors into a single electronic repository. CEBS has undergone significant updates in recent years and currently contains over 11 000 test articles (exposure agents) and over 8000 studies including all available NTP carcinogenicity, short-term toxicity and genetic toxicity studies...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27897465/predicting-young-adults-risk-for-engaging-in-prescription-drug-misuse-in-daily-life-from-individual-partner-and-relationship-factors
#11
Lauren M Papp, Chrystyna D Kouros
BACKGROUND: Mounting evidence based on retrospective and global assessments has established associations between prescription drug misuse and illicit drug use, alcohol abuse, mental health problems, risky sexual behaviors, and overdose deaths. However, there is a notable absence of identified risk and protective factors for an individual's likelihood of engaging in misuse in real-world environments. METHODS: Using an experience sampling approach, we collected repeated moments of young adults' (n = 95 participants drawn from 49 romantic couples) prescription drug misuse instances in daily life, and tested multiple factors associated with the misuse...
November 29, 2016: Substance Abuse
https://www.readbyqxmd.com/read/27894884/modulation-of-the-heat-shock-response-is-associated-with-acclimation-to-novel-temperatures-but-not-adaptation-to-climatic-variation-in-the-ants-aphaenogaster-picea-and-a-rudis
#12
Sara Helms Cahan, Andrew D Nguyen, John Stanton-Geddes, Clint A Penick, Yainna Hernáiz-Hernández, Bernice B DeMarco, Nicholas J Gotelli
Ecological diversification into thermally divergent habitats can push species toward their physiological limits, requiring them to accommodate temperature extremes through plastic or evolutionary changes that increase persistence under the local thermal regime. One way to withstand thermal stress is to increase production of heat shock proteins, either by maintaining higher baseline abundance within cells or by increasing the magnitude of induction in response to heat stress. We evaluated whether environmental variation was associated with expression of three heat shock protein genes in two closely-related species of woodland ant, Aphaenogaster picea and A...
November 25, 2016: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27890148/seated-reach-capabilities-for-ergonomic-design-and-evaluation-with-consideration-of-reach-difficulties
#13
Qun Liu, Jindong Ren, Qian Zhang, Meng Hua
This paper aimed to identify the reach capabilities of 26 seated subjects considering the reach difficulty, orientation and other potential factors, and to find a method to model the minimum reach capability surfaces for fixed and adjustable seats. The reach capability radius was used as a measure of the reach capability and theoretically modeled. Based on the test data of seated reach, the distribution of the reach capability radius was analyzed. The strategy to select the minimum reach envelopes was constructed to accommodate a sufficient percentage of the target population for both fixed and adjustable seats...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27885404/-health-examination-of-asylum-seekers-a-nationwide-analysis-of-state-policies-in-germany-%C3%A2-%C3%A2-62-of-the-asylum-law
#14
Katharina Wahedi, Stefan Nöst, Kayvan Bozorgmehr
BACKGROUND: A health examination of newly arrived asylum seekers, aimed at detecting infectious diseases and preventing disease outbreaks in accommodation facilities, is mandated by national law in all German states. Due to the decentralized German federal system, different state policies are in place and lead to substantial variation in the content and implementation of the health examination. OBJECTIVES: To compare health examination policies in the 16 German states with a focus on conducted tests, preventive measures and the general procedure...
November 24, 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27885098/energy-costs-and-performance-of-transfemoral-amputees-and-non-amputees-during-walking-and-running-a-pilot-study
#15
Larry J Mengelkoch, Jason T Kahle, M Jason Highsmith
BACKGROUND: Limited information is available concerning the effects of prosthetic foot components on energy costs and ambulatory performance for transfemoral amputees. OBJECTIVES: Compare energy costs (VO2; gait economy) and ambulatory performance (self-selected walking speeds, self-selected running speeds, peak running speeds) differences during walking and running for transfemoral amputees and matched, non-amputee runners. STUDY DESIGN: Repeated measures...
November 24, 2016: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/27876513/are-high-lags-of-accommodation-in-myopic-children-due-to-motor-deficits
#16
Vivek Labhishetty, William R Bobier
Children with a progressing myopia exhibit an abnormal pattern of high accommodative lags coupled with high accommodative convergence (AC/A) and high accommodative adaptation. This is not predicted by the current models of accommodation and vergence. Reduced accommodative plant gain and reduced sensitivity to blur have been suggested as potential causes for this abnormal behavior. These etiologies were tested by altering parameters (sensory, controller and plant gains) in the Simulink model of accommodation...
November 25, 2016: Vision Research
https://www.readbyqxmd.com/read/27875937/operator-adaptation-to-changes-in-system-reliability-under-adaptable-automation
#17
Alain Chavaillaz, Juergen Sauer
This experiment examined how operators coped with a change in system reliability between training and testing. 40 participants were trained for 3h on a complex process control simulation modelling six levels of automation (LOA). In training, participants either experienced a high- (100%) or low-reliability system (50%). The impact of training experience on operator behaviour was examined during a 2.5h testing session, in which participants either experienced a high- (100%) or low-reliability system (60%). The results showed that most operators did not often switch between LOA...
November 23, 2016: Ergonomics
https://www.readbyqxmd.com/read/27873014/binocular-function-changes-produced-in-response-to-overnight-orthokeratology
#18
Gema Felipe-Marquez, María Nombela-Palomo, Catalina Palomo-Álvarez, Isabel Cacho, Amelia Nieto-Bona
PURPOSE: To analyze the binocular function changes produced on subjects undergoing overnight orthokeratology (OK) treatment over short-term (3 months) and long-term (3 years) wear. METHODS: A prospective, longitudinal study on young adult subjects with low to moderate myopia was carried out. Binocular function was assessed by the following sequence of tests: Distance and near horizontal phoria (Von Graefe technique), distance and near horizontal vergence ranges (Risley rotary prisms), accommodative convergence/accommodation (AC/A) ratio (gradient method) and the near point of convergence (standard push-up technique)...
November 21, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27872073/exploring-the-role-of-the-%C3%AE-loop-in-the-evolution-of-ceftazidime-resistance-in-the-pena-%C3%AE-lactamase-from-burkholderia-multivorans-an-important-cystic-fibrosis-pathogen
#19
Krisztina M Papp-Wallace, Scott A Becka, Magdalena A Taracila, Elise T Zeiser, Julian A Gatta, John J LiPuma, Robert A Bonomo
The unwelcome evolution of resistance to the advanced generation cephalosporin antibiotic, ceftazidime is hindering the effective therapy of Burkholderia cepacia complex (Bcc) infections. Regrettably, Bcc are highly resistant to most antibiotics, including polymyxins; ceftazidime and trimethoprim-sulfamethoxazole are the most effective treatment options. Unfortunately, resistance to ceftazidime is increasing and posing a health threat to populations susceptible to Bcc infection. We found that up to 36% of 146 tested Bcc clinical isolates were non-susceptible to ceftazidime...
November 21, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27871056/fampridine-treatment-and-walking-distance-in-multiple-sclerosis-a-randomised-controlled-trial
#20
Hannah Pickering, Jenna Murray, Cindy S-Y Lin, Christine Cormack, Andrew Martin, Matthew C Kiernan, Arun V Krishnan
OBJECTIVE: To explore the benefits of modified-release fampridine on walking distance in MS. METHODS: This was a randomised double-blind, placebo-controlled crossover trial of fampridine in 25 MS patients. The primary outcome measure was the six minute walk test (6MWT). A p-value<10% led to rejection of the null hypothesis. RESULTS: The pre-specified criterion for statistical significance was met, with a 17m improvement in 6MWT in the treatment arm...
November 2, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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