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https://www.readbyqxmd.com/read/29222290/chronic-organ-failure-in-adult-sickle-cell-disease
#1
REVIEW
Elliott Vichinsky
Sickle cell disease is now a chronic adult illness characterized by progressive multiorgan failure, particularly involving the brain and kidney. The etiology is multifactorial; it includes hemolysis and nitric oxide deficiency. As patients age, most experience neurologic insult. Twenty-five percent of older adults have had a clinical stroke and at least half of the population have had a silent infarct, cortical atrophy, and neurocognitive impairment. Periodic screening with neuroimaging and neurocognitive testing is recommended...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29219754/shunt-scissors-technical-note
#2
Ralph G Dacey, Oliver E Flouty, M Sean Grady, Matthew A Howard, Marc R Mayberg
OBJECTIVE When performing ventriculoperitoneal shunt surgery it is necessary to create a subgaleal pocket that is of sufficient size to accommodate a shunt valve. In most cases the valve is placed over the posterior skull where the galea begins to transition to suboccipital neck fascia. Dense fibrous attachments in this region of the skull make it technically awkward to develop the subgaleal valve pocket using standard scissors and a blunt dissection technique. In this report the authors describe a new device that enables surgeons to create the shunt valve pocket by using a simple semi-sharp dissection technique...
December 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29218829/intraclass-correlation-improved-modeling-approaches-and-applications-for-neuroimaging
#3
Gang Chen, Paul A Taylor, Simone P Haller, Katharina Kircanski, Joel Stoddard, Daniel S Pine, Ellen Leibenluft, Melissa A Brotman, Robert W Cox
Intraclass correlation (ICC) is a reliability metric that gauges similarity when, for example, entities are measured under similar, or even the same, well-controlled conditions, which in MRI applications include runs/sessions, twins, parent/child, scanners, sites, and so on. The popular definitions and interpretations of ICC are usually framed statistically under the conventional ANOVA platform. Here, we provide a comprehensive overview of ICC analysis in its prior usage in neuroimaging, and we show that the standard ANOVA framework is often limited, rigid, and inflexible in modeling capabilities...
December 7, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29214403/executive-functioning-academic-skills-and-quality-of-life-in-pediatric-patients-with-brain-tumors-post-proton-radiation-therapy
#4
Lea M Ventura, Julie A Grieco, Casey L Evans, Karen A Kuhlthau, Shannon M MacDonald, Nancy J Tarbell, Torunn I Yock, Margaret B Pulsifer
Radiation therapy (RT) is integral in the treatment of pediatric brain tumors; however, photon RT (XRT) often results in intellectual decline, executive functioning (EF) deficits, academic underachievement/failure, and lower health-related quality of life (HRQoL). Proton RT (PRT) provides more targeted therapy, minimizing damage to the developing brain, yet few studies have examined its neuropsychological effects. This study investigated the role of EF in academic skills and HRQoL in a sample of children treated with PRT...
December 6, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29211918/decellularized-human-placenta-supports-hepatic-tissue-and-allows-rescue-in-acute-liver-failure
#5
Zurab Kakabadze, Anne Kakabadze, David Chakhunashvili, Lika Karalashvili, Ekaterine Berishvili, Yogeshwar Sharma, Sanjeev Gupta
Tissue engineering with scaffolds to form transplantable organs is of wide interest. Decellularized tissues have been tested for this purpose, although supplies of healthy donor tissues, vascular recellularization for perfusion and tissue homeostasis in engineered organs pose challenges. We hypothesized decellularized human placenta will be suitable for tissue engineering. The universal availability and unique structures of placenta for accommodating tissue, including presence of embedded vessels, were major attractions...
December 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29211780/prevalence-and-antibiotic-resistance-of-pseudomonas-aeruginosa-in-water-samples-in-central-italy-and-molecular-characterization-of-oprd-in-imipenem-resistant-isolates
#6
Giuditta Fiorella Schiavano, Elisa Carloni, Francesca Andreoni, Silvia Magi, Maria Chironna, Giorgio Brandi, Giulia Amagliani
SCOPE: This study aimed to analyse the prevalence, antibiotic resistance and genetic relatedness of P. aeruginosa isolates obtained from potable and recreational water samples (n. 8,351) collected from different settings (swimming pools, n. 207; healthcare facilities, n 1,684; accommodation facilities, n. 1,518; municipal waterworks, n. 4,500; residential buildings, n. 235). Possible mechanisms underlying resistance to imipenem, with particular focus on those involving oprD-based uptake, were also explored...
2017: PloS One
https://www.readbyqxmd.com/read/29211730/a-continuous-morphological-approach-to-study-the-evolution-of-pollen-in-a-phylogenetic-context-an-example-with-the-order-myrtales
#7
Ricardo Kriebel, Mohammad Khabbazian, Kenneth J Sytsma
The study of pollen morphology has historically allowed evolutionary biologists to assess phylogenetic relationships among Angiosperms, as well as to better understand the fossil record. During this process, pollen has mainly been studied by discretizing some of its main characteristics such as size, shape, and exine ornamentation. One large plant clade in which pollen has been used this way for phylogenetic inference and character mapping is the order Myrtales, composed by the small families Alzateaceae, Crypteroniaceae, and Penaeaceae (collectively the "CAP clade"), as well as the large families Combretaceae, Lythraceae, Melastomataceae, Myrtaceae, Onagraceae and Vochysiaceae...
2017: PloS One
https://www.readbyqxmd.com/read/29208869/prediction-of-un-erupted-canine-and-premolar-tooth-size-in-mixed-dentition-among-bangladeshi-population
#8
R Chokrobrty, T Rafique, R Ghosh, A K Biswas, M Sajedeen, G S Hassan
Accurate prediction of the space available to accommodate the size of the un-erupted canines and premolars plays an important role in mixed dentition in Orthodontics. This Descriptive cross sectional study was carried out in the Department of Orthodontics of Bangabandhu Sheikh Mujib Medical University from July 2014 to June 2015. Dental study models of 140 patients were taken as sample. The sample was consisted of 54 Bangladeshi males and 86 females aged between 12 to 17 years and without any previous orthodontic treatment fully erupted permanent teeth and with no dental anomalies were recruited...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29205378/cardiac-gated-parametric-images-from-82-rb-pet-from-dynamic-frames-and-direct-4d-reconstruction
#9
Mary Germino, Richard E Carson
PURPOSE: Cardiac perfusion PET data can be reconstructed as a dynamic sequence and kinetic modeling performed to quantify myocardial blood flow, or reconstructed as static gated images to quantify function. Parametric images from dynamic PET are conventionally not gated, to allow use of all events with lower noise. An alternative method for dynamic PET is to incorporate the kinetic model into the reconstruction algorithm itself, bypassing the generation of a time series of emission images and directly producing parametric images...
December 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/29202205/3d-mice-integration-of-cross-sectional-and-longitudinal-imputation-for-multi-analyte-longitudinal-clinical-data
#10
Yuan Luo, Peter Szolovits, Anand S Dighe, Jason M Baron
Objective: A key challenge in clinical data mining is that most clinical datasets contain missing data. Since many commonly used machine learning algorithms require complete datasets (no missing data), clinical analytic approaches often entail an imputation procedure to "fill in" missing data. However, although most clinical datasets contain a temporal component, most commonly used imputation methods do not adequately accommodate longitudinal time-based data. We sought to develop a new imputation algorithm, 3-dimensional multiple imputation with chained equations (3D-MICE), that can perform accurate imputation of missing clinical time series data...
November 30, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29197264/blended-learning-pedagogy-designed-for-communication-module-among-undergraduate-nursing-students-a-quasi-experimental-study
#11
Shefaly Shorey, Yanika Kowitlawakul, M Kamala Devi, Hui-Chen Chen, Swee Kit Alan Soong, Emily Ang
BACKGROUND: Effective communication is important for nurse and patient outcomes. Nursing students often feel unprepared to communicate effectively with patients and other healthcare workers within the clinical environment. Blended learning pedagogy-based communication skills training can provide an alternative to traditional methods of teaching to enhance students' satisfaction and self-efficacy levels in communicating with others. OBJECTIVES: To examine the effectiveness of blended learning pedagogy in a redesigned communication module among nursing undergraduates in enhancing their satisfaction levels and attitudes towards learning communication module as well as self-efficacy in communication...
November 16, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29196995/epigenetics-and-preeclampsia-programming-of-future-outcomes
#12
Alberto Borges Peixoto, Liliam Cristine Rolo, Luciano Marcondes Machado Nardozza, Edward Araujo Júnior
Pregnancy is known to induce rapid, progressive, and substantial changes to the cardiovascular system, ultimately facilitating successful pregnancy outcomes. Women who develop hypertensive disorders during pregnancy are considered to have "failed" the cardiovascular stress test of pregnancy and likely represent a subpopulation with inadequate cardiovascular accommodation. Preeclampsia is a serious complication with a myriad of manifestations in both mother and offspring. This pregnancy syndrome is a polygenic disease and has now been linked to a greater incidence of cardiovascular disease...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29190701/a-non-threshold-region-specific-method-for-detecting-rare-variants-in-complex-diseases
#13
Ai-Ru Hsieh, Dao-Peng Chen, Amrita Sengupta Chattopadhyay, Ying-Ju Li, Chien-Ching Chang, Cathy S J Fann
A region-specific method, NTR (non-threshold rare) variant detection method, was developed-it does not use the threshold for defining rare variants and accounts for directions of effects. NTR also considers linkage disequilibrium within the region and accommodates common and rare variants simultaneously. NTR weighs variants according to minor allele frequency and odds ratio to combine the effects of common and rare variants on disease occurrence into a single score and provides a test statistic to assess the significance of the score...
2017: PloS One
https://www.readbyqxmd.com/read/29187343/an-ehealth-application-of-self-reported-sports-related-injuries-and-illnesses-in-paralympic-sport-pilot-feasibility-and-usability-study
#14
Kristina Fagher, Jenny Jacobsson, Örjan Dahlström, Toomas Timpka, Jan Lexell
BACKGROUND: Sport participation is associated with a risk of sports-related injuries and illnesses, and Paralympic athletes' additional medical issues can be a challenge to health care providers and medical staff. However, few prospective studies have assessed sports-related injuries and illnesses in Paralympic sport (SRIIPS) over time. Advances in mobile phone technology and networking systems offer novel opportunities to develop innovative eHealth applications for collection of athletes' self-reports...
November 29, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/29179016/group-family-based-cognitive-behavioral-therapy-for-pediatric-obsessive-compulsive-disorder-global-outcomes-and-predictors-of-improvement
#15
Robert R Selles, Laura Belschner, Juliana Negreiros, Sarah Lin, David Schuberth, Katherine McKenney, Noel Gregorowski, Annie Simpson, Andrea Bliss, S Evelyn Stewart
This open, uncontrolled study examined the efficacy of a group family-based cognitive behavioral therapy (GF-CBT) protocol in treating pediatric obsessive-compulsive disorder (OCD) and explored predictors of symptom improvement. Eighty-five OCD-affected youth aged 8-18 years (M = 13.9 years, SD = 2.49; 46% male) and their parent(s) participated in a weekly, 12-session GF-CBT program. Data from multiple perspectives were gathered at the beginning and end of treatment, as well as at one-month follow-up. A broad range of assessment measures were utilized to capture clinically-relevant domains and a number of potential predictor variables were explored...
November 15, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29176833/characterization-of-small-to-medium-head-and-face-dimensions-for-developing-respirator-fit-test-panels-and-evaluating-fit-of-filtering-facepiece-respirators-with-different-faceseal-design
#16
Yi-Chun Lin, Chen-Peng Chen
A respirator fit test panel (RFTP) with facial size distribution representative of intended users is essential to the evaluation of respirator fit for new models of respirators. In this study an anthropometric survey was conducted among youths representing respirator users in mid-Taiwan to characterize head-and-face dimensions key to RFTPs for application to small-to-medium facial features. The participants were fit-tested for three N95 masks of different facepiece design and the results compared to facial size distribution specified in the RFTPs of bivariate and principal component analysis design developed in this study to realize the influence of facial characteristics to respirator fit in relation to facepiece design...
2017: PloS One
https://www.readbyqxmd.com/read/29174394/visual-and-binocular-status-in-elementary-school-children-with-a-reading-problem
#17
Lisa W Christian, Krithika Nandakumar, Patricia K Hrynchak, Elizabeth L Irving
PURPOSE: This descriptive study provides a summary of the binocular anomalies seen in elementary school children identified with reading problems. METHODS: A retrospective chart review of all children identified with reading problems and seen by the University of Waterloo, Optometry Clinic, from September 2012 to June 2013. RESULTS: Files of 121 children (mean age 8.6 years, range 6-14 years) were reviewed. No significant refractive error was found in 81% of children...
November 21, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/29171873/let-it-go-relationship-autonomy-predicts-pro-relationship-responses-to-partner-transgressions
#18
Benjamin W Hadden, Zachary G Baker, C Raymond Knee
OBJECTIVE: The purpose of the present research is to better understand how relationship autonomy-having more self-determined reasons for being committed to a relationship-contributes to pro-relationship responses to transgressions in romantic relationships (e.g., forgiveness and accommodation). METHODS: Study 1 employed a cross-sectional design (N=350) and Study 2 used a weekly diary (N=121) to test associations between relationship autonomy and pro-relationship responses to transgressions...
November 24, 2017: Journal of Personality
https://www.readbyqxmd.com/read/29170349/52%C3%A2-loop-mediated-isothermal-amplification-pcr-lamp-for-the-rapid-identification-of-invasive-meningococcal-disease-in-the-emergency-department
#19
Thomas Waterfield, Bethany Patenall, James McKenna, Derek Fairley
BACKGROUND: Despite successful vaccination programmes meningococcal disease (MD) remains the leading infectious cause of septicaemia and death in children in the UK and Ireland.(1,2) The early diagnosis of MD significantly improves outcomes with reduced morbidity and mortality.(1,2) The early stages of MD are often indistinguishable from a simple viral illness making an early positive diagnosis of MD difficult.(1) Hibergene have developed a commercially available bedside Loop-mediated isothermal AMPlification PCR (LAMP-MD) test that is a highly sensitive 0...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29168146/novel-direct-annuloplasty-fastener-system-for-minimally-invasive-mitral-valve-repair
#20
Joshua L Chan, Ming Li, Dumitru Mazilu, Justin G Miller, Andrada C Diaconescu, Keith A Horvath
The development of less invasive approaches for mitral valve repair remains an important objective, particularly in patients with multiple comorbidities. We describe a novel method to affix a mitral valve annuloplasty ring in a minimally invasive manner. A delivery apparatus for an annuloplasty fastener system was designed. Two channels were created, one for advancing the annuloplasty ring, and another to accommodate the fastener applicator. Custom designed fasteners, either with a helical-shaped screw or a strap-shaped tack structure, were tested...
November 22, 2017: Cardiovascular Engineering and Technology
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