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https://www.readbyqxmd.com/read/28716090/clinical-workflow-for-mr-only-simulation-and-planning-in-prostate
#1
Neelam Tyagi, Sandra Fontenla, Michael Zelefsky, Marcia Chong-Ton, Kyle Ostergren, Niral Shah, Lizette Warner, Mo Kadbi, Jim Mechalakos, Margie Hunt
PURPOSE: To describe the details and experience of implementing a MR-only workflow in the clinic for simulation and planning of prostate cancer patients. METHODS: Forty-eight prostate cancer patients from June 2016 - Dec 2016 receiving external beam radiotherapy were scheduled to undergo MR-only simulation. MR images were acquired for contouring (T2w axial, coronal, sagittal), synthetic-CT generation (3D FFE-based) and fiducial identification (3D bFFE-based). The total acquisition time was 25 min...
July 17, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28712949/role-of-early-second-trimester-uterine-artery-doppler-screening-to-predict-small-for-gestational-age-babies-in-nulliparous-women
#2
Samuel Parry, Anthony Sciscione, David M Haas, William A Grobman, Jay D Iams, Brian M Mercer, Robert M Silver, Hyagriv N Simhan, Ronald J Wapner, Deborah A Wing, Michal A Elovitz, Frank P Schubert, Alan Peaceman, M Sean Esplin, Steve Caritis, Michael P Nageotte, Benjamin A Carper, George R Saade, Uma M Reddy, Corette B Parker
BACKGROUND: Trophoblastic invasion of the uterine spiral arteries substantially increases compliance to accommodate increased blood flow to the placenta. Failure of this process impedes uterine artery blood flow, and this may be detected by uterine artery Doppler flow studies. However, the clinical utility of uterine artery Doppler flow studies in the prediction of adverse pregnancy outcomes in a general population remains largely unknown. OBJECTIVE: To determine the utility of early second trimester uterine artery Doppler studies as a predictor of small for gestational age (SGA) neonates...
July 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28712715/split-vmat-technique-to-control-the-expiratory-breath-hold-time-in-liver-stereotactic-body-radiation-therapy
#3
Yen Hwa Lin, Shuichi Ozawa, Hideharu Miura, Katsunori Yogo, Takeo Nakashima, Kentaro Miki, Shintaro Tsuda, Yusuke Ochi, Daisuke Kawahara, Tomoki Kimura, Akito Saito, Yasushi Nagata
PURPOSE: In this study, we demonstrate the feasibility of using split-arcs in volumetric modulated arc therapy (VMAT), tailored for expiratory breath-hold in stereotactic body radiation therapy (SBRT) for liver tumors. We compare it with three-dimensional conformal radiation therapy (3D-CRT) and continuous-VMAT, for ten randomly selected hepatocellular carcinoma cases. METHODS: Four coplanar and four non-coplanar beams were used for the 3D-CRT plans. A pair of partial arcs, chosen using a back-and-forth rotating motion, were used for the continuous-VMAT plans...
July 13, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28711242/a-method-of-outdoor-housing-dairy-calves-in-pairs-using-individual-calf-hutches
#4
L Wormsbecher, R Bergeron, D Haley, A M de Passillé, J Rushen, E Vasseur
Interest in housing dairy calves in groups is currently growing. Group housing using individual calf hutches, a resource already available in most dairy farms in North America, could provide a novel housing method that can be a simple way to implement group housing on farm. The main objective of this study was to determine whether pair housing dairy calves in hutches outdoors would result in similar weight gain and milk intake compared with individual housing in hutches. The study was designed to avoid competition for resources (including milk and solid feed, teat, bucket, outdoor space, and hutch) to test a setup that has the potential to maximize performance and calf growth...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28709908/variable-rna-expression-from-recently-acquired-endogenous-viral-elements-eve-of-white-spot-syndrome-virus-wssv-in-shrimp
#5
Heny Budi Utari, Chumporn Soowannayan, Timothy W Flegel, Boonsirm Whityachumnarnkul, Maleeya Kruatrachue
The viral accommodation hypothesis proposes that endogenous viral elements (EVE) from both RNA and DNA viruses are being continually integrated into the shrimp genome by natural host processes and that they can result in tolerance to viral infection by fortuitous production of antisense, immunospecific RNA (imRNA). Thus, we hypothesized that previously reported microarray results for the presence of white spot syndrome virus (WSSV) open reading frames (ORFs) formerly called 151, 366 and 427 in a domesticated giant tiger shrimp (Penaeus monodon) breeding stock might have represented expression from EVE, since the stock had shown uninterrupted freedom from white spot disease (WSD) for many generations...
July 11, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28708914/misfit-of-three-different-implant-abutment-connections-before-and-after-cyclic-load-application-an-in-vitro-study
#6
Sergio Alexandre Gehrke, Rafael Arcesio Delgado-Ruiz, Juan Carlos Prados Frutos, María Prados-Privado, Berenice Anina Dedavid, Jose Manuel Granero Marín, José Luiz Calvo Guirado
PURPOSE: This study aimed to evaluate the misfit of three different implant-abutment connections before and after cycling load. MATERIALS AND METHODS: One hundred twenty dental implants and correspondent prefabricated titanium abutments were used. Three different implant-abutment connections were evaluated: Morse taper (MT group), external hexagon (EH group), and internal hexagon (IH group). Forty implants and 40 abutments were used per group. The parameters for the mechanical evaluation were set as: 360,000 cycles, load of 150 N, and frequency of 4 Hz...
July 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28708697/simultaneous-physical-and-mental-effort-alters-visual-function
#7
Jesús Vera, Raimundo Jiménez, José Antonio García, David Cárdenas
PURPOSE: Perceptual processing is sensitive to physiological changes. Thus, the homeostatic disturbances during and after exercise may alter the visual function. Here, we investigated the effect of simultaneous physical effort and two levels of cognitive demand on skills related to the visuoperceptual and motor processing. METHODS: Eighteen male regular exercisers performed 60 minutes of simultaneous physical exercise (cycling at 60 ± 5% of reserve heart rate) and cognitive effort (mental workload)...
July 14, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28704467/locomotor-adaptability-in-persons-with-unilateral-transtibial-amputation
#8
Benjamin J Darter, Amy J Bastian, Erik J Wolf, Elizabeth M Husson, Bethany A Labrecque, Brad D Hendershot
BACKGROUND: Locomotor adaptation enables walkers to modify strategies when faced with challenging walking conditions. While a variety of neurological injuries can impair locomotor adaptability, the effect of a lower extremity amputation on adaptability is poorly understood. OBJECTIVE: Determine if locomotor adaptability is impaired in persons with unilateral transtibial amputation (TTA). METHODS: The locomotor adaptability of 10 persons with a TTA and 8 persons without an amputation was tested while walking on a split-belt treadmill with the parallel belts running at the same (tied) or different (split) speeds...
2017: PloS One
https://www.readbyqxmd.com/read/28696773/rail-height-effects-on-safety-performance-of-midwest-guardrail-system
#9
Mojdeh Asadollahi Pajouh, Ramen D Julin, Cody S Stolle, John D Reid, Ronald K Faller
OBJECTIVE: Guardrail heights play a crucial role in the way that errant vehicles interact with roadside barriers. Low rail heights increase the propensity of vehicle rollover and override, while excessively-tall rails promote underride. Further, rail mounting heights and post embedment depths may be altered by variations in roadside terrain. An increased guardrail height may be desirable to accommodate construction tolerances, soil erosion, frost heave, and future roadway overlays. This study aimed to investigate and identify a maximum safe installation height for the Midwest Guardrail System, which would be robust and remain crashworthy before and after pavement overlays...
July 11, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28692997/automated-classification-and-removal-of-eeg-artifacts-with-svm-and-wavelet-ica
#10
Chong Yeh Sai, Norrima Mokhtar, Hamzah Arof, Paul Cumming, Masahiro Iwahashi
Brain electrical activity recordings by electroencephalography (EEG) are often contaminated with signal artifacts. Procedures for automated removal of EEG artifacts are frequently sought for clinical diagnostics and brain computer interface (BCI) applications. In recent years, a combination of independent component analysis (ICA) and discrete wavelet transform (DWT) has been introduced as standard technique for EEG artifact removal. However, in performing the wavelet-ICA procedure, visual inspection or arbitrary thresholding may be required for identifying artifactual components in the EEG signal...
July 4, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28692542/the-effect-of-oral-pre-exposure-prophylaxis-on-the-progression-of-hiv-1-seroconversion
#11
Deborah Donnell, Eric Ramos, Connie Celum, Jared Baeten, Joan Dragavon, Jordan Tappero, Jairam R Lingappa, Allan Ronald, Kenneth Fife, Robert W Coombs
OBJECTIVE: To investigate whether oral pre-exposure prophylaxis (PrEP) alters timing and patterns of seroconversion when PrEP use continues after HIV-1 infection. DESIGN: Retrospective testing of the timing of Fiebig stage HIV-1 seroconversion in the Partners PrEP Study, a randomized placebo-controlled clinical trial of PrEP conducted in Kenya and Uganda. METHODS: Specimens from 138 seroconverters were collected every 3 months and when HIV-1 infection was suspected based on monthly rapid HIV-1 tests...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28691574/enhancement-of-a-prosthetic-knee-with-a-microprocessor-controlled-gait-phase-switch-reduces-falls-and-improves-balance-confidence-and-gait-speed-in-community-ambulators-with-unilateral-transfemoral-amputation
#12
Sara Agueda Fuenzalida Squella, Andreas Kannenberg, Ângelo Brandão Benetti
BACKGROUND: Despite the evidence for improved safety and function of microprocessor stance and swing-controlled prosthetic knees, non-microprocessor-controlled prosthetic knees are still standard of care for persons with transfemoral amputations in most countries. Limited feature microprocessor-control enhancement of such knees could stand to significantly improve patient outcomes. OBJECTIVES: To evaluate gait speed, balance, and fall reduction benefits of the new 3E80 default stance hydraulic knee compared to standard non-microprocessor-controlled prosthetic knees...
July 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28687868/comparative-toxicity-of-two-chemical-dispersants-and-dispersed-oil-in-estuarine-organisms
#13
M E DeLorenzo, P B Key, K W Chung, E Pisarski, B Shaddrix, E F Wirth, P L Pennington, J Wade, M Franco, M H Fulton
Chemical dispersants can be a useful tool to mitigate oil spills. This study examined potential risks to sensitive estuarine species by comparing the toxicity of two dispersants (Corexit(®) EC9500A and Finasol(®) OSR 52) individually and in chemically enhanced water-accommodated fractions (CEWAFs) of Louisiana Sweet Crude oil. Acute toxicity thresholds and sublethal biomarker responses were determined in seven species (sheepshead minnow, grass shrimp, mysid, amphipod, polychaete, hard clam, mud snail). Comparing median lethal (LC50) values for the dispersants, Finasol was generally more toxic than Corexit and had greater sublethal toxicity (impaired embryonic hatching, increased lipid peroxidation, decreased acetylcholinesterase activity)...
July 7, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28685443/environmental-enrichment-induces-increased-cerebral-capillary-density-and-improved-cognitive-function-in-mice
#14
Chuan He, Constantinos P Tsipis, Joseph C LaManna, Kui Xu
Enrichment provides an environment that fosters increased physical activity and sensory stimulation as compared to standard housing. Promoting and sustaining stimulation increases neuronal activity and, consequently, brain oxygen demand. The mammalian brain modulates its microvascular network to accommodate tissue energy demand in a process referred to as angioplasticity. In this study we investigated the effect of an environmental enrichment on cerebral capillary density and cognitive performance in mice. Microvascular density (N/mm(2)) was determined by GLUT-1 immunohistochemistry in mice (3 months old) after 3 weeks of placement in a non-enriched or an enriched environment...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28683752/tnseqdiff-identification-of-conditionally-essential-genes-in-transposon-sequencing-studies
#15
Lili Zhao, Mark T Anderson, Weisheng Wu, Harry L T Mobley, Michael A Bachman
BACKGROUND: Tn-Seq is a high throughput technique for analysis of transposon mutant libraries to determine conditional essentiality of a gene under an experimental condition. A special feature of the Tn-seq data is that multiple mutants in a gene provides independent evidence to prioritize that gene as being essential. The existing methods do not account for this feature or rely on a high-density transposon library. Moreover, these methods are unable to accommodate complex designs. RESULTS: The method proposed here is specifically designed for the analysis of Tn-Seq data...
July 6, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28683303/cellular-changes-of-stem-cells-in-3-dimensional-culture
#16
Matthew P Green, Bo Hou
PURPOSE: During various operations and procedures, such as distraction osteogenesis and orthodontics, skeletal tissues use mechanotransduction. Mechanotransduction is important for maintaining bone health and converting mechanical forces into biochemical signals. We hypothesized that cells put under mechanical stress would adapt and change morphologically and respond with a decrease in cellular proliferation to accommodate the stress differences. These differences will be measured at the molecular and genetic level...
June 12, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28681436/human-eyes-do-not-need-monochromatic-aberrations-for-dynamic-accommodation
#17
Paula Bernal-Molina, Iván Marín-Franch, Antonio J Del Águila-Carrasco, Jose J Esteve-Taboada, Norberto López-Gil, Philip B Kruger, Robert Montés-Micó
PURPOSE: To determine if human accommodation uses the eye's own monochromatic aberrations to track dynamic accommodative stimuli. METHODS: Wavefront aberrations were measured while subjects monocularly viewed a monochromatic Maltese cross moving sinusoidally around 2D of accommodative demand with 1D amplitude at 0.2 Hz. The amplitude and phase (delay) of the accommodation response were compared to the actual vergence of the stimulus to obtain gain and temporal phase, calculated from wavefront aberrations recorded over time during experimental trials...
July 5, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28678866/correlation-between-investment-in-sexual-traits-and-valve-sexual-dimorphism-in-cyprideis-species-ostracoda
#18
Maria João Fernandes Martins, Gene Hunt, Rowan Lockwood, John P Swaddle, David J Horne
Assessing the long-term macroevolutionary consequences of sexual selection has been hampered by the difficulty of studying this process in the fossil record. Cytheroid ostracodes offer an excellent system to explore sexual selection in the fossil record because their readily fossilized carapaces are sexually dimorphic. Specifically, males are relatively more elongate than females in this superfamily. This sexual shape difference is thought to arise so that males carapaces can accommodate their very large copulatory apparatus, which can account for up to one-third of body volume...
2017: PloS One
https://www.readbyqxmd.com/read/28677368/functional-properties-of-different-collagen-scaffolds-to-create-a-biomimetic-niche-for-neurally-committed-human-induced-pluripotent-stem-cells-ipsc
#19
Krystyna Pietrucha, Marzena Zychowicz, Martyna Podobinska, Leonora Buzanska
<i>The biomimetic, standardized conditions for <i><i><i><i><i>in vitro</i></i></i></i></i> cultures of human neural progenitors derived from induced pluripotent stem cells (hiPSC-NPs) should meet the requirements to serve as the template and protective environment for therapeutically competent cell population. In this study, two different collagen scaffolds: bi-component consisting of collagen and chondroitin sulphate (Col-CS), and collagen modified by crosslinking agent 2,3-dialdehyde cellulose (Col-DAC) have been used for the first time to encapsulate hiPSC-NPs and compared for the ability to create permissive microenvironment enabling cell survival, growth and differentiation...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28672398/peripheral-design-of-progressive-addition-lenses-and-the-lag-of-accommodation-in-myopes
#20
Tim Schilling, Arne Ohlendorf, Saulius R Varnas, Siegfried Wahl
Purpose: Insufficient accommodative response is assumed to result in myopia progression. We have investigated if the accommodative lag in myopes is different between a single vision lens (SVL) and the progressive addition lens PAL 2, clinically trialled for its ability to reduce progression of myopia, and if there exist differences in accommodative lag between PAL 2 and other PALs with the same addition power (+1.50 D). Methods: The influence of spherical SVL and four different designs of PALs that differ in the near zone width (PAL 1) or that have different signs and magnitude of horizontal gradients of mean power adjacent to their near vision zones (PAL 3 and PAL 4) on the accommodative response was investigated for different near viewing distances (40, 33, and 25 cm) in 31 subjects, aged 18 to 25 years...
July 1, 2017: Investigative Ophthalmology & Visual Science
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