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Mark R D Gatus, Mohan Bhadbhade, Barbara A Messerle
Two highly versatile xanthene scaffolds containing pairs of heteroditopic ligands were found to be capable of accommodating a range of transition metal ions, including Au(i), Ir(i), Ir(iii), Rh(i), and Ru(ii) to generate an array of heterobimetallic complexes. The metal complexes were fully characterised and proved to be stable in the solid and solution state, with no observed metal-metal scrambling. Heterobimetallic complexes containing the Rh(i)/Ir(i) combinations were tested as catalysts for the two-step dihydroalkoxylation reaction of alkynediols and sequential hydroamination/hydrosilylation reaction of alkynamines...
October 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Gideon Ampoma Gyebi, Joseph Oluwatope Adebayo, Olufunke Esan Olorundare, Antoni Pardede, Masayuki Ninomiya, Afolabi Olanrewaju Saheed, Abiola Samuel Babatunde, Mamoru Koketsu
Gongronema latifolium Benth (Asclepiadaceae) is an edible-green-leafy vegetable with known medicinal value. A chemical investigation of the 80% methanolic extract of the leaves led to the isolation of a new pregnane glycoside: iloneoside (3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→14)-β-D-oleandropyranosyl]-11,12-di-O-tigloyl-17β-marsdenin), together with four known constituents. Their chemical structures were determined by spectroscopic analysis. The isolates were tested for their in vitro growth inhibitory activity against human leukemia HL-60 cells...
October 16, 2017: Natural Product Research
Terry L Wade, Maya Morales-McDevitt, Gopal Bera, Dawai Shi, Stephen Sweet, Binbin Wang, Gerado Gold-Bouchot, Antonietta Quigg, Anthony H Knap
Marine oil snow (MOS) formation is a mechanism to transport oil from the ocean surface to sediments. We describe here the use of 110L mesocosms designed to mimic oceanic parameters during an oil spill including the use of chemical dispersants in order to understand the processes controlling MOS formation. These experiments were not designed to be toxicity tests but rather to illustrate mechanisms. This paper focuses on the development of protocols needed to conduct experiments under environmentally relevant conditions to examine marine snow and MOS...
October 2017: Heliyon
Umberto Albert, Alessandra Baffa, Giuseppe Maina
The term accommodation has been used to refer to family responses specifically related to obsessive-compulsive (OC) symptoms: it encompasses behaviors such as directly participating in compulsions, assisting a relative with obsessive-compulsive disorder (OCD) when he/she is performing a ritual, or helping him/her to avoid triggers that may precipitate obsessions and compulsions. At the opposite side, family responses to OCD may also include interfering with the rituals or actively opposing them; stopping accommodating OC symptoms or actively interfering with their performance is usually associated with greater distress and sometimes even with aggressive behaviors from the patients...
2017: Psychology Research and Behavior Management
Zeyu Yang, Yujuan Hua, Fatemeh Mirnaghi, Bruce P Hollebone, Paula Jackman, Carl E Brown, Chun Yang, Keval Shah, Mike Landriault, Brian Chan
In this study, the water accommodated and particle-laden hydrocarbon species, and the toxicity of the aqueous phase after oil-sediment interactions by varying the weathering states of diluted bitumen (Cold Lake blend (CLB)), oil type from light to heavy, and sediment type. Compared to the original oils, the sediment-laden total petroleum hydrocarbons (TPH) contained fewer hydrocarbons in the carbon range <C10, comparable contents in C10-C16 range, higher contents in both the C16-C34 and >C34 range. Sediment-laden oil amounts generally decreased with an increased viscosity and asphaltene content of the test oils, as well as with increased sediment particle size...
October 6, 2017: Chemosphere
Shaymaa E Kassab, Mohammed A Khedr, Hamed I Ali, Mohamed M Abdalla
New ring-extended analogs of indomethacin were designed based on the structure of active binding site of both COX-1 and COX-2 isoenzymes and the interaction pattern required for selective inhibition of COX-2 to improve its selectivity against COX-2. The strategy adopted for designing the new inhibitors involved i) ring extension of indomethacin to reduce the possibility of analogs to be accommodated into the narrow hydrophobic tunnel of COX-1, ii) deletion of carboxylic acid to reduce the possibility of inhibitor to form salt bridge with Arg120 and eventually prevent COX-1 inhibition, and iii) introduction of methylsulfonyl group to increase the opportunity of the analogs to interact with the polar side pocket that's is crucial for inhibition process of COX-2...
September 28, 2017: European Journal of Medicinal Chemistry
Heather M Jensen, Thomas Eng, Victor Chubukov, Robin A Herbert, Aindrila Mukhopadhyay
Expression of membrane proteins often leads to growth inhibition and perturbs central metabolism and this burden varies with the protein being overexpressed. There are also known strain backgrounds that allow greater expression of membrane proteins but that differ in efficacy across proteins. We hypothesized that for any membrane protein, it may be possible to identify a modified strain background where its expression can be accommodated with less burden. To directly test this hypothesis, we used a bar-coded transposon insertion library in tandem with cell sorting to assess genome-wide impact of gene deletions on membrane protein expression...
October 12, 2017: Scientific Reports
Dimosthenis Chochlakis, Vassilios Sandalakis, Maria Keramarou, Yannis Tselentis, Anna Psaroulaki
OBJECTIVES: Although a number of human Legionnaires' disease in tourists are recorded annually in Europe, there are few cases where a direct link can be made between the infected person and the source of infection (hotel or other accommodation). We present a scheme followed in order to track down and identify the source of infection in a tourist suffering from L. pneumophila sg 5 infection, who was accommodated in seven different hotels during his holidays in the island of Crete, and we comment on various difficulties and draw-backs of the process...
September 2017: Central European Journal of Public Health
Mace G Barron, Robyn N Conmy, Edith L Holder, Peter Meyer, Gregory J Wilson, Vanessa E Principe, Morgan M Willming
Dilbits are blends of bitumen and natural gas condensates or crude oils with only limited toxicity data. Two dilbits, Cold Lake Blend and Western Canadian Select, were tested as either unweathered or weathered oils for acute and chronic toxicity to standard freshwater and estuarine organisms. Water accommodated fractions of the dilbits were characterized for total petroleum hydrocarbons (TPH), polycyclic aromatic hydrocarbons (PAHs), and monoaromatics (BTEX). Acute toxicity of unweathered and weathered dilbits ranged from 4 to 16 mg/L TPH, 8 to 40 μg/L total PAHs, and 0...
October 4, 2017: Chemosphere
Ruth H Keogh, Rhian M Daniel, Tyler J Vanderweele, Stijn Vansteelandt
Estimation of causal effects of time-varying exposures using longitudinal data is a common problem in epidemiology. When there are time-varying confounders, which may include past outcomes, affected by prior exposure, standard regression methods can lead to bias. Methods such as inverse probability weighted estimation of marginal structural models have been developed to address this problem. However, in this paper we show how standard regression methods can be used, even in the presence of time-dependent confounding, to estimate the total effect of an exposure on a subsequent outcome by controlling appropriately for prior exposures, outcomes and time-varying covariates...
September 6, 2017: American Journal of Epidemiology
Ryan Avery, Kevin Day, Clinton Jokerst, Toshinobu Kazui, Elizabeth Krupinski, Zain Khalpey
BACKGROUND: Advanced heart failure treated with a left ventricular assist device is associated with a higher risk of right heart failure. Many advanced heart failures patients are treated with an ICD, a relative contraindication to MRI, prior to assist device placement. Given this limitation, left and right ventricular function for patients with an ICD is calculated using radionuclide angiography utilizing planar multigated acquisition (MUGA) and first pass radionuclide angiography (FPRNA), respectively...
October 10, 2017: Journal of Cardiothoracic Surgery
Lidia Anguiano Gómez, Yutian Lei, Satish Kumar Devarapu, Hans-Joachim Anders
Curing 'diabetic nephropathy' is considered an unmet medical need of high priority. We propose to question the concept of 'diabetic nephropathy' that implies diabetes as the predominant cause of kidney disease, which may not apply to the majority of type 2 diabetics approaching end-stage kidney disease. With the onset of diabetes, hyperglycaemia/sodium-glucose co-transporter-2-driven glomerular hyperfiltration promotes nephron hypertrophy, which, however, on its own, causes proteinuria not before a decade later, probably because podocyte hypertrophy can usually accommodate an increase in the filtration surface...
July 31, 2017: Nephrology, Dialysis, Transplantation
Bishnu P Khanal, Moritz Knoche
Cuticles envelope primary surfaces of the above-ground portion of plants. They function as barriers to water movement and to gas exchange, and in pathogen defense. To serve as a barrier on growing organs, cuticles must remain intact but at the same time must accommodate ongoing growth. Minimizing cuticle failure has stimulated significant research on the cuticle's mechanical properties. The objective here is to review the literature on the mechanical properties of isolated fruit and leaf cuticles. Cuticles are viscoelastic polymers...
September 13, 2017: Journal of Experimental Botany
M W Jacobson, M Ketcha, A Uneri, J Goerres, T De Silva, S Reaungamornrat, S Vogt, G Kleinszig, J H Siewerdsen
PURPOSE: Traditional BB-based geometric calibration methods for cone-beam CT (CBCT) rely strongly on foreknowledge of the scan trajectory shape. This is a hindrance to the implementation of variable trajectory CBCT systems, normally requiring a dedicated calibration phantom or software algorithm for every scan orbit of interest. A more flexible method of calibration is proposed here that accommodates multiple orbit types - including strongly noncircular trajectories - with a single phantom and software routine...
March 2017: Proceedings of SPIE
Kristen Pammer, Stephanie Sabadas, Stephanie Lentern
OBJECTIVE: To determine whether inattentional blindness (IB) can be used to understand the psychological mechanisms around looked-but-failed-to-see (LBFTS) crashes involving motorcycles Background: IB occurs when an observer looks directly at an object yet fails to see it, thus LBFTS crashes may be a real-world example of IB. The study tests a perceptual cycle model in which motorcycles are detected less frequently because they fall lower on the attentional hierarchy for driving. METHOD: A driving-related IB task with photographs of driving situations investigated whether an additional stimulus, a taxi or motorcycle, would be more likely to be missed by participants...
October 1, 2017: Human Factors
E P Tarutta, N A Tarasova, S G Аrutyunyan, M V Maksimova
AIM: To study the magnitude of objective accommodative response (OAR) with account to the method of image defocusing. The latter can be realized by bringing the object nearer to the eye or by adding a minus lens in front of the viewer. MATERIAL AND METHODS: We examined 63 patients (126 eyes) with different refraction aged from 7 to 31 years. All patients underwent a series of OAR measurements on WR-5100K Grand Seiko Binocular Open-Field Autorefkeratometer under different conditions, including negative spherical lenses of -3...
2017: Vestnik Oftalmologii
Junghyun Namkung, Sungho Won
Family-based association analysis unconditional on parental genotypes models the effects of observed genotypes. This approach has been shown to have greater power than conditional methods. In this chapter, we review popular association analysis methods accounting for familial correlations: the marginal model using generalized estimating equations (GEE), the mixed model with a polygenic random component, and genome-wide association analyses. The marginal approach does not explicitly model familial correlations but uses the information to improve the efficiency of parameter estimates...
2017: Methods in Molecular Biology
Ren-Hua Chung, Daniel D Kinnamon, Eden R Martin
Family-based designs have been commonly used in association studies. Different family structures such as extended pedigrees and nuclear families, including parent-offspring triads and families with multiple affected siblings (multiplex families), can be ascertained for family-based association analysis. Flexible association tests that can accommodate different family structures have been proposed. The pedigree disequilibrium test (PDT) (Martin et al., Am J Hum Genet 67:146-154, 2000) can use full genotype information from general (possibly extended) pedigrees with one or multiple affected siblings but requires parental genotypes or genotypes of unaffected siblings...
2017: Methods in Molecular Biology
Perry Orthey, Daohai Yu, Mark L Van Natta, Frederick V Ramsey, Jesus R Diaz, Paige A Bennett, Andrei H Iagaru, Roberto Salas Fragomeni, Richard W McCallum, Irene Sarosiek, William L Hasler, Gianrico Farrugia, Madhusudan Grover, Kenneth L Koch, Linda Nguyen, William J Snape, Thomas L Abell, Pankaj J Pasricha, James Tonascia, Frank Hamilton, Henry P Parkman, Alan H Maurer
Impaired fundic accommodation (FA) limits fundic relaxation and ability to act as a reservoir for food. Assessing intragastric meal distribution (IMD) during gastric emptying scintigraphy (GES) allows for a simple measure of FA. GOALS: 1) Evaluate nuclear medicine and radiology physician trained readers' visual assessment of FA from solid-meal GES; 2) Develop software to quantify GES intragastric meal distribution (IMD); 3) Correlate symptoms of gastroparesis with IMD and GE. Methods: After training to achieve consensus interpretation of GES FA, 4 readers interpreted FA in 148 GES studies from normal volunteers and patients...
September 28, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Tatana Sramkova, Katerina Skrivanova, Igor Dolan, Libor Zamecnik, Katerina Sramkova, Jiri Kriz, Vladimir Muzik, Radmila Fajtova
INTRODUCTION: After spinal cord injury (SCI), individuals are typically considered by the general public to be asexual. Handicapped women have more problems with socio-sexual adaptation, stemming from low self-confidence, low self-esteem, and the absence of spontaneity. AIMS: To determine changes in the sexual lives of women after SCI. METHODS: A self-constructed questionnaire was used to map sexual function after SCI. We retrospectively compared sexual function in 30 women with SCI with that in 30 without SCI who led an active sexual life...
September 29, 2017: Sexual Medicine
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