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Glaucia Suzanna Jong-A-Liem, Talita Helena Martins Sarti, Mariusi Glasenapp Dos Santos, Luciano Marcus Tirotti Giacon, Raphael Wuo-Silva, Alex Machado Baeta, José Maria de Campos Filho, Feres Chaddad-Neto
INTRODUCTION: Mutations of the phosphatase and tensin homolog (PTEN) gene have been associated with a spectrum of disorders called PTEN hamartoma tumor syndrome, which predisposes the individual to develop various types of tumors and vascular anomalies. Its phenotypic spectrum includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), Proteus syndrome, autism spectrum disorders (ASD), some sporadic cancers, Lhermitte-Duclos disease (LDD), and various types of associated vascular anomalies...
2024: Frontiers in Neurology
#2
JOURNAL ARTICLE
M A Ensha Lomiya, R Raguvaran, Debabrata Mondal, Shivangi Dosar, Sonu S Nair, K R Jitha, A R Chandni, Navjot Singh Thakur, Narayani Yadav, Kaveri Jambagi
Urinary tract infection (UTI) caused by antimicrobial resistant bacteria is common in dogs leading to serious health impact in pet animal as well as on human health. Understanding the prevalent uropathogens and their drug susceptibility is essential for limiting the antimicrobial resistance through implementation of stewardship policies. In view of this, present study was envisaged to determine the prevalent bacterial uropathogens and their antibiogram from clinical cases of canine UTI. Urine samples were collected from 35 dogs presented with clinical signs of UTI and a total of 27 bacterial isolates were recovered...
April 22, 2024: Veterinary Research Communications
#3
REVIEW
Mohamed Chakkour, Zeinab Hammoud, Solay Farhat, Ali El Roz, Zeinab Ezzeddine, Ghassan Ghssein
Proteus mirabilis is a Gram-negative bacterium with exclusive molecular and biological features. It is a versatile pathogen acclaimed for its distinct urease production, swarming behavior, and rapid multicellular activity. Clinically, P. mirabilis is a frequent pathogen of the human urinary system where it causes urinary tract infections (UTIs) and catheter-associated urinary tract infections (CAUTIs). This review explores the epidemiology, risk factors, clinical manifestations, and treatment of P. mirabilis infections, emphasizing its association with UTIs...
2024: Frontiers in Microbiology
#4
JOURNAL ARTICLE
Vladimira Hinić, Helena M B Seth-Smith, Sabrina Stammler, Adrian Egli
Current methods for plasmid-mediated AmpC β-lactamase (pAmpC) detection in routine microbiological laboratories are based on various phenotypic tests. Eazyplex®SuperBug AmpC assay is a molecular assay based on isothermal amplification for rapid detection of the most common pAmpC types from bacterial culture: CMY-2 group, DHA, ACC and MOX. Our aim was to evaluate the diagnostic performance of this assay. The assay was evaluated on 64 clinical isolates of Enterobacterales without chromosomal inducible AmpC, and with phenotypically confirmed AmpC production...
April 18, 2024: Journal of Microbiological Methods
#5
JOURNAL ARTICLE
Amina Bougouizi, Zohra Chekroud, Hamza Rahab, Ali Boumegoura, Abdelaziz Touati
INTRODUCTION: The spread of Carbapenemase-producing Enterobacterales (CPEs) has become a significant concern in Algeria, with limited data available on their presence in community settings. This research investigated the resistance mechanisms of carbapenem-resistant Enterobacterales (CREs) collected from hospitals and the community in Skikda city, Algeria, between December 2020 and June 2022. METHODOLOGY: The study collected Enterobacterales strains resistant to ertapenem from inpatient and outpatient populations...
March 31, 2024: Journal of Infection in Developing Countries
#6
JOURNAL ARTICLE
Afia Sakyiwaa Amponsah, Gloria Mathanda Ankar-Brewoo, Herman Erick Lutterodt, Isaac Williams Ofosu
The ever-increasing demand for wildlife-derived raw or processed meat commonly known as bushmeat, has been identified as one of the critical factors driving the emergence of infectious diseases. This study focused on examining the bacterial community composition of smoked and fermented bushmeats, specifically grasscutter, rat, rabbit, and mona monkey. The analysis involved exploring 16Sr RNA amplicon sequences isolated from bushmeat using QIIME2. Microbiome profiles and their correlation with proximate components (PLS regression) were computed in STAMP and XLSTAT, respectively...
2024: Biotechnologia
#7
JOURNAL ARTICLE
Attaur Rahman, Saiqa Sardar, Zeeshan Niaz, Asif Khan, Sheheryar, Abdulwahed Fahad Alrefaei, Muhammad Hamayun, Sajid Ali
BACKGROUND: Surgical site infections are one of the major clinical problems in surgical departments that cost hundreds of millions of dollars to healthcare systems around the world. AIM: The study aimed to address the pressing issue of surgical site infections, which pose significant clinical and financial burdens on healthcare systems globally. Recognizing the substantial costs incurred due to these infections, the research has focused on understanding the role of lipase and protease production by multi-drug resistant bacteria isolated from surgical wounds in the development of post-surgical wound infections...
April 15, 2024: Current Pharmaceutical Design
#8
JOURNAL ARTICLE
Kuenyoul Park, Heungsup Sung, Mi-Na Kim
BACKGROUND: We evaluated the diagnostic performance of the FilmArray Blood Culture Identification Panel (BCID; bioMerieux) for the detection of bloodstream pathogens. METHODS: From May to August 2022, up to 67 samples from positive blood cultures previously processed with BACTEC FX (BD) were collected and submitted to the BCID panel. BCID panel results were compared with traditional culture results. RESULTS: We tested 67 positive blood culture samples; 13 samples were from pediatric bottles of BACTEC Peds Plus/F media (BD)...
April 1, 2024: Clinical Laboratory
#9
JOURNAL ARTICLE
Peifan Li, Tong Tong, Xinyu Shao, Yan Han, Michael Zhang, Yongli Li, Xue Lv, Hao Li, Zuming Li
This study aimed to assess the impact of Lactobacillaceae (L or H represents a low or high dose), inulin (I), and polydextrose (P) combined with aerobic exercise (A) on the composition of the gut microbiota and metabolic profiles in db/db mice. After a 12-week intervention, LIP, LIPA, and HIPA groups exhibited significant improvements in hyperglycemia, glucose tolerance, insulin resistance, inflammatory response, and short-chain fatty acid (SCFA) and blood lipid levels compared to type 2 diabetes mice (MC)...
April 16, 2024: Food & Function
#10
JOURNAL ARTICLE
Simona Mondellini, Michael Schwarzer, Matthias Völkl, Julia Jasinski, Valérie Jérôme, Thomas Scheibel, Christian Laforsch, Ruth Freitag
Microplastics (MP) have become a well-known and widely investigated environmental pollutant. Despite the huge amount of new studies investigating the potential threat posed by MP, the possible uptake and trophic transfer in lower trophic levels of freshwater ecosystems remains understudied. This study aims to investigate the internalization and potential trophic transfer of fluorescent polystyrene (PS) beads (0.5 μm, 3.6 × 108 particles/mL; 6 μm, 2.1 × 105 particles/mL) and fragments (<30 μm, 5 × 103 particles/mL) in three unicellular eukaryotes...
April 13, 2024: Science of the Total Environment
#11
JOURNAL ARTICLE
Shaoling Yang, Liye Hu, Yue Zhao, Guangzhe Meng, Sijia Xu, Rui Han
Multidrug-resistant (MDR) bacterial infections have become increasingly common in recent years due to the increased prevalence of diabetic foot ulcers (DFUs). We carried out a meta-analysis aimed at investigating the prevalence of MDR bacteria isolated from DFUs and analysing the risk factors for MDR bacterial infection in patients with DFUs. The PubMed/Medline, Web of Science, Embase, Cochrane Library, Ovid, Scopus, and ProQuest databases were searched for studies published up to November 2023 on the clinical outcomes of MDR bacteria in DFUs...
April 2024: International Wound Journal
#12
Ashwin Mohandas Pallath, Gayatri Gopan, Anoop Tm
No abstract text is available yet for this article.
May 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#13
JOURNAL ARTICLE
Muhammad Naveed, Fatima Tahir, Tariq Aziz, Muhammad Waseem, Syeda Izma Makhdoom, Nouman Ali, Metab Alharbi, Thamer H Albekairi, Abdullah F Alasmari
Heavy metal accumulation increases rapidly in the environment due to anthropogenic activities and industrialization. The leather and surgical industry produces many contaminants containing heavy metals. Cadmium, a prominent contaminant, is linked to severe health risks, notably kidney and liver damage, especially among individuals exposed to contaminated wastewater. This study aims to leverage the natural cadmium resistance mechanisms in bacteria for bioaccumulation purposes. The industrial wastewater samples, characterized by an alarming cadmium concentration of 29...
April 12, 2024: Scientific Reports
#14
JOURNAL ARTICLE
Jolanta Prywer, Agnieszka Torzewska, Ewa Mielniczek-Brzóska
Taking into account that in recent decades there has been an increase in the incidence of urinary stones, especially in highly developed countries, from a wide range of potentially harmful substances commonly available in such countries, we chose zinc for the research presented in this article, which is classified by some sources as a heavy metal. In this article, we present the results of research on the influence of Zn2+ ion on the nucleation and growth of struvite crystals-the main component of infection urinary stones...
April 10, 2024: Metallomics: Integrated Biometal Science
#15
JOURNAL ARTICLE
Hong Zhang, Yinlin Luo, Xincheng Zhao, Xiande Liu
Cancer immunotherapy based on bioengineering of bacteria can effectively increase anticancer immune responses. However, few studies have investigated the antitumor potential of engineering Proteus mirabilis . Here, we genetically engineered P. mirabilis to overexpress Vibrio vulnificus flagellin B (FlaB) protein in a murine CT26 tumor model. We found that a large number of FlaB-expressing P. mirabilis colonized tumor tissues, enhanced T cell infiltration and secretion of cytokines and cytotoxic proteins in tumors, and significantly restrained tumor growth...
March 21, 2024: Mol Ther Oncol
#16
JOURNAL ARTICLE
Su Min Kyung, Jun Ho Lee, Eun-Seo Lee, Xi-Rui Xiang, Han Sang Yoo
Proteus mirabilis is a commensal bacterium dwelling in the gastrointestinal (GI) tract of humans and animals. Although New Delhi metallo-β-lactamase 1 (NDM-1) producing P. mirabilis is emerging as a threat, its epidemiology in our society remains largely unknown. LHPm1, the first P. mirabilis isolate harboring NDM-1, was detected from a companion dog that resides with a human owner. The whole-genome study revealed 20 different antimicrobial resistance (AMR) genes against various classes of antimicrobial agents, which corresponded to the MIC results...
April 9, 2024: Veterinary Research
#17
JOURNAL ARTICLE
Ghizlane Nouioura, Mohamed El Fadili, Azeddin El Barnossi, El Hassania Loukili, Hassan Laaroussi, Mohammed Bouhrim, John P Giesy, Mourad A M Aboul-Soud, Yazeed A Al-Sheikh, Badiaa Lyoussi, El Houssine Derwich
Although giant fennel is recognized as a "superfood" rich in phytochemicals with antioxidant activity, research into the antibacterial properties of its fruits has been relatively limited, compared to studies involving the root and aerial parts of the plant. In this study, seven solvents-acetone, methanol, ethanol, ethyl acetate, chloroform, water, and hexane-were used to extract the chemical constituents of the fruit of giant fennel (Ferula communis), a species of flowering plant in the carrot family Apiaceae...
April 9, 2024: Scientific Reports
#18
JOURNAL ARTICLE
Yuvarajan Subramaniyan, Altaf Khan, M Mujeeburahiman, Punchappady Devasya Rekha
Urological diseases affect all age groups and are associated with different urinary complications. Presence of pathogenic bacteria complicates the urological diseases such as chronic kidney disease (CKD), kidney stone disease (KSD), emphysematous pyelonephritis (EPN), and urological cancers (UCs) coinciding with urinary metabolic complications. The One Health concept for preventing the spread of antibiotic resistant opportunistic pathogens necessitates detailed investigation on the virulence and the antibiotic sensitivity patterns of the pathogens from the urinary tract infections (UTIs)...
April 8, 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
#19
MULTICENTER STUDY
Aidyn G Salmanov, Yuliia V Strakhovetska, Olha D Leshchova, Volodymyr Artyomenko, Svitlana M Korniyenko, Victor O Rud, Nataliia M Nastradina, Igor V Kokhanov
OBJECTIVE: Aim: To determine the current prevalence of endometritis after hysteroscopic procedures and antimicrobial resistance of responsible pathogens in Ukraine. PATIENTS AND METHODS: Materials and Methods: Multicenter prospective cohort study was conducted from January 2020 to December 2022 in fifteen hospitals from twelve regions of Ukraine. Definitions of endometritis were adapted from the Centers for Disease Control and Prevention's National Healthcare Safety Network...
2024: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
#20
JOURNAL ARTICLE
Kanao Kobayashi, Satoshi Takahashi, Mitsuru Yasuda, Jun Miyazaki, Koichiro Wada, Masahiro Matsumoto, Hiroshi Hayami, Shingo Yamamoto, Hiroshi Kiyota, Junko Sato, Tetsuya Matsumoto, Naoki Hasegawa, Intetsu Kobayashi, Naoya Masumori, Takahiro Kimura, Hiroki Yamada, Tohru Nakagawa, Tomoyuki Kaneko, Kazumasa Matsumoto, Tetsuya Fujimura, Jun Kamei, Kiyohito Ishikawa, Kiyohide Fujimoto, Yasushi Nakai, Katsumi Shigemura, Takuya Sadahira, Nobuyuki Hinata, Hiroyuki Kitano, Masuo Yamashita, Tomihiko Yasufuku, Hisao Komeda, Yoshiki Hiyama, Yoshito Takahashi, Sojun Kanamaru, Masaya Murakami, Soichi Arakawa, Daisuke Yamada, Koji Mita, Ryoichi Hamasuna, Kazushi Tanaka, Masanori Matsukawa, Eiichiro Takaoka, Masanobu Shigeta, Tadasu Takenaka, Masashi Nishino, Satoshi Ishitoya, Shohei Hayakawa, Kazuhiro Okumura, Masakatsu Ueda
INTRODUCTION: Antimicrobial susceptibility patterns of bacterial pathogens isolated from patients with complicated urinary tract infections were analyzed using the national surveillance data, comprising 793 bacterial strains from eight clinically relevant species. MATERIALS AND METHODS: Data were collected for the fourth national surveillance project from July 2020 to December 2021 by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Disease, and the Japanese Society of Clinical Microbiology...
April 6, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
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