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Eugene Vernyuy Yeika, Joyce Bei Foryoung, Derrick Tembi Efie, Eugene Adze Nkwetateba, Paul Nkemtendong Tolefac, Marcelin Ngowe Ngowe
BACKGROUND: Necrotizing fasciitis is a rare soft tissue infection characterized by rapid progressive necrosis with relative sparing of underlying muscles. This case is reported to highlight the emergence of multidrug resistant microbes in recent days which limits the use of empiric antibiotic therapy and necessitates early cultures and sensitivity enabling targeted antibiotic therapy. Factors that lead to antimicrobial resistance especially in sub-Saharan Africa have also been discussed...
May 21, 2018: BMC Research Notes
Kevin Muñoz Forti, Faviola Bernard, Gustavo Santiago-Collazo, Waldemar Garcia, Jose L Vera, Enrique Meléndez, Edu B Suarez-Martinez
Introduction: Bacterial antibiotic resistance is on rise despite advances in the development of new antibiotics. In an attempt to circumvent resistance, scientists are shifting focus from modifying existent antibiotics to identifying new antibiotic compounds. Aim: To assess the potential antibiotic effects of functionalised ferrocenecarboxylates para-substituted on the phenoxy pendant group to form: 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, 4-iodophenyl and 4-(H-pyrrol-1-yl)phenyl...
February 2018: Journal of Clinical and Diagnostic Research: JCDR
Govindan Rajivgandhi, Muthuchamy Maruthupandy, Natesan Manoharan
The multidrug resistant Gram negative bacteria (MDRGNB) is an emerging burden and now represents a daily challenge for the management of antimicrobial therapy in healthcare settings. The present study was aimed to detect the prevalence of TEM and CTX-M type genes from GNB on urinary tract infection (UTIs). The ciprofloxacin resistant uropathogens were detected by HEXA UTI 5 disc diffusion method. The phenotypic detection of uropathogens producing extended spectrum beta lactamases (ESBLs) was confirmed by double disc combination (DDCT) and phenotype confirmation methods (PCT)...
May 17, 2018: Microbial Pathogenesis
Sana Farooq Ahmad, Ibrar Khan, Abdul Wadood, Sadiq Azam, Noor Rehman, Muhammad Waqas, Kashif Bashir, Asaf Ali Khan
Hospitals are the most prominent places for the growth and spread of bacteria which are resistant to the available antibiotics. This antibiotic resistance is due to the over and misuse of antibiotic dosages of a high-density of patient population which are in frequent interaction with inanimate items of the hospitals and the consequent risk of cross infection. Out of 1010 samples of the current study, 510 (50.49%) were culture positive of which 329 (64.5%) were Gram-positive while 181 (35.49%) Gram negative...
April 22, 2018: Computational Biology and Chemistry
Venkataseshan Jagannathan, Pragasam Viswanathan
Struvite or infection stones are one of the major clinical burdens among urinary tract infection, which occur due to the interaction between microbes and urine mineral components. Numerous urinary tract infection (UTI) causing microbes regulate through biofilm formation for survival from host defense, it is often found difficult in its eradication with simple anti-microbial agents and also the chance of recurrence and resistance development is significantly high. Cranberry consumption and maintenance of urinary tract health have been supported by clinical, epidemiological, and mechanistic studies...
May 18, 2018: Journal of Basic Microbiology
Amon Ryakitimbo, Rune Philemon, Festo Mazuguni, Levina Msuya
Background: Urinary tract infection (UTI) in children with cerebral palsy (CP) is a challenging yet common clinical condition. Children with CP bare the greatest risk of contracting UTI because of their difficulties in neuromotor control which lead to delay of bladder control, causing incomplete bladder emptying and urine retention. Method: This was an analytical cross-sectional study that was conducted from September 2016 to March 2017 at Comprehensive Community Based Rehabilitation in Tanzania - Moshi and Kilimanjaro Christian Medical Centre Neurological Pediatrics Outpatient Clinic...
2018: Pediatric Health, Medicine and Therapeutics
Shivangi Goyal, Nidhi Gupta, Ajeet Kumar, Sreemoyee Chatterjee, Surendra Nimesh
In this study, the authors report a simple and eco-friendly method for the synthesis of silver nanoparticles (AgNPs) using Trigonella foenum-graecum (TFG) seed extract. They explored several parameters dictating the biosynthesis of TFG-AgNPs such as reaction time, temperature, concentration of AgNO3 , and TFG extract amount. Physicochemical characterisation of TFG-AgNPs was done on dynamic light scattering (DLS), field emission electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction and Fourier transform infrared spectroscopy...
June 2018: IET Nanobiotechnology
Shichen Yu, Xiaoshan Zhu, Jin Zhou, Zhonghua Cai
Biofilms play an important role in the antibiotic resistance of encased bacteria, and biofilm formation is regulated by quorum sensing (QS). Inhibiting the QS system may, therefore, degrade the integrity of a biofilm and expose the bacterial pathogens within it to the deleterious effects of molecules such as antibiotics. Moreover, the use of QS inhibitors (QSIs) may provide a novel approach for treating bacterial infections of aquacultures. In the present study, the bacterium Proteus mirabilis was identified as a potential producer of QSIs...
April 2018: Royal Society Open Science
Yan Liang, Weifeng Xu, Chengmei Liu, Dexiong Zhou, Xiaobo Liu, Yuyue Qin, Fei Cao, Jun Li, Ruiyun Yang, Jiangke Qin
A new eremophilane sesquiterpene, xylareremophil (1), together with five known eremophilanes, 1α,10α-epoxy-3α-hydroxyeremophil-7(11)-en-12,8β-olide (2), 1,10α,13-trihydroxyeremophil-7(11)-en-12,8-olide (3), 1α,10α-epoxy-13-hydroxyeremophil-7(11)-en-12,8β-olide (4), mairetolides B (5) and G (6) were isolated from the endophytic fungus Xylaria sp. GDG-102 cultured from Sophora tonkinensis. Their structures were elucidated on the basis of spectroscopic data analysis. The absolute configurations of 1 was determined by comparing computed electronic circular dichroism (ECD) and optical rotation (OR) with experimental results...
May 15, 2018: Natural Product Research
Luka Bielen, Robert Likić, Viktorija Erdeljić, Ivana Mareković, Nataša Firis, Marijana Grgić-Medić, Ana Godan, Ivan Tomić, Blaženka Hunjak, Alemka Markotić, Danijela Bejuk, Vladimira Tičić, Silvana Balzar, Branka Bedenić
AIM: To determine in vitro susceptibility of multiresistant bacterial isolates to fosfomycin. METHODS: In this prospective in vitro study (local non-random sample, level of evidence 3), 288 consecutively collected multiresistant bacterial isolates from seven medical centers in Croatia were tested from February 2014 until October 2016 for susceptibility to fosfomycin and other antibiotics according to Clinical and Laboratory Standards Institute methodology. Susceptibility to fosfomycin was determined by agar dilution method, while disc diffusion was performed for in vitro testing of other antibiotics...
April 30, 2018: Croatian Medical Journal
Acke Ohlin, Emma Mattsson, Matthias Mörgelin, Julia R Davies, Gunnel Svensäter, Stéphane Corvec, Pentti Tengvall, Kristian Riesbeck
PURPOSE: Post-operative infections are relatively common after posterior spine surgery, and there are several observations reflecting different infection complications related to various metals implanted. Here, we selected an array of different bacterial species that are often found in infections associated with orthopaedic implants and tested for inhibition by hydrogen peroxide-treated titanium (Ti-peroxy). METHODS: To study the possibility of using Ti-peroxy as an antimicrobial prophylaxis, we developed a protocol for standardized susceptibility testing of bacteria...
May 7, 2018: European Spine Journal
Alfred Maroyi
Syzygium cordatum is a valuable medicinal plant in the materia medica of east and southern Africa. The aim of this study was to review the botany, medicinal uses, phytochemistry and ethnopharmacological properties of S. cordatum . Relevant literature search was carried out using internet sources such as ACS, Web of Science, Wiley, SpringerLink, Scopus, Mendeley, Google Scholar, Pubmed, SciFinder, BioMed Central, Science Direct and Elsevier. Other literature sources were conference papers, book chapters, books, theses and websites...
May 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Manikandan Dhayalan, Michael Immanuel Jesse Denison, Manikandan Ayyar, N N Gandhi, Kathiravan Krishnan, Baykal Abdulhadi
In modern era, the great interest and demand among chemists and researchers for metal nanoparticles is increasing in the application of biomedical fields, textiles, cosmetics and various sectors. Consequently, the present study reports an eco-friendly, cost-effective, rapid and easy method to produce environment-friendly metal nanoparticles to prevent exhaustion of metal resources. In this context, gold and silver metal nanoparticles were green synthesized using the Root Extract of Coleous forskohlii (RECo) as capping and reducing agent...
May 1, 2018: Journal of Photochemistry and Photobiology. B, Biology
Mohamed A El-Mokhtar, Helal F Hetta
Background: Ambulances may represent a potential source of infection to patients, patients' relatives, and paramedical staffs. In this study, we analyzed the extent of bacterial contamination in ambulance vehicles and measured the degree of antimicrobial resistance among isolated pathogens. Materials and methods: Twenty-five vehicles were included and 16 sampling points were swabbed in each vehicle. Then the swabs were immediately transferred to the laboratory to identify bacterial contaminants utilizing standard microbiological procedures and API® systems...
2018: Infection and Drug Resistance
Azza S El-Demerdash, Mohamed G Aggour, Mona M El-Azzouny, Sally H Abou-Khadra
The study investigated 110 Enterobacteriaceae isolates from broiler chickens isolated from Sharkia poultry farms and analyzed the isolates antimicrobial resistance and the presence of integrons as a potential basis for this resistance. Antibiotic susceptibilities against 12 different antibiotics were determined by the disk diffusion method. Prevalences and classes of integrons were then detected in multi-drug resistant (MDR) strains using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) followed by sequencing of the variable parts...
April 30, 2018: Cellular and Molecular Biology
Ayad M R Raauf, Rafah F Al-Smaism, Khalida A Thejeel, Hala Ayad M Rasheed
New compounds of trimethoprim heterocyclic derivatives were synthesized. These compounds were synthesized through the condensation reaction between trimethoprim with bromoacetic acid to yield compound 1. Several Schiff bases 2-7 have been synthesized by the condensation different aromatic aldehydes with compound 1. Compound 8 were formed from the reaction of sodium nitrite and acetyl acetone in presence of conc. hydrogen chloride to obtain the hydrazono derivative; then, Cyclocondensation of compound 8 with hydrazine hydrate, phenyl hydrazine and dinitrophenyl hydrazine respectively to yield compounds 9-11 in ethanol affording the pyrazoline derivatives...
May 4, 2018: Natural Product Research
Joanna Kwiecińska-Piróg, Krzysztof Skowron, Agata Śniegowska, Jana Przekwas, Maciej Balcerek, Daniel Załuski, Eugenia Gospodarek-Komkowska
Alcoholic propolis extracts may be used to eliminate microbes in mucous membranes and skin inflammations and in wound infections. The aim of this study was an assessment of the ethanol extract of propolis (EEP) activity against biofilm formation by P. mirabilis. Six clinical strains of P. mirabilis isolated from patients with chronic wound infection, and one reference strain of P. mirabilis ATCC 29906 were used. Biofilm was formed in 96-well plate. In order to evaluate the effect of EEP at a concentration range of 1...
May 4, 2018: Natural Product Research
Laura De Petris, Ermanno Ruffini
Raoultella ornithinolytica is a Gram-negative, non-motile, encapsulated, aerobic bacillus belonging to the Enterobacteriaceae family. R. ornithinolytica is a not very common, but emergent causal agent of human infection, and its expression of beta-lactamase provides resistance to commonly used antibiotics. The pathogenetic potential of R. ornithinolytica isolates in human disease has become increasingly important. Several cases of hospital-acquired infection, mostly associated with invasive procedures, or in patients with co-morbidity caused by R...
May 2, 2018: CEN Case Reports
V Morozova, Yu Kozlova, E Shedko, I Babkin, A Kurilshikov, O Bokovaya, A Bardashova, A Yunusova, A Tikunov, A Tupikin, T Ushakova, E Ryabchikova, N Tikunova
Four lytic Proteus bacteriophages, PM75, PM85, PM93, and PM116, which are active against multi-drug-resistant strains of P. mirabilis, were isolated from cattle and poultry samples. According to electron microscopy data, all of the investigated phages belonged to the family Podoviridae. They all demonstrated lytic activity against sensitive strains of P. mirabilis, and three of the phages, PM85, PM93, and PM116, are potential candidates for use in antibacterial treatment. The genomes and putative proteins of bacteriophages PM85, PM93, and PM116 were similar to those of Proteus phage vB_PmiP_Pm5460 [KP890822], and the investigated phages formed a distinct clade within the genus Sp6virus, subfamily Autographivirinae...
May 2, 2018: Archives of Virology
Fabian Uddén, Matuba Filipe, Åke Reimer, Maria Paul, Erika Matuschek, John Thegerström, Sven Hammerschmidt, Tuula Pelkonen, Kristian Riesbeck
BACKGROUND: Chronic suppurative otitis media (CSOM) is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions. Topical antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some areas. The goal of this study was to define aerobic pathogens associated with CSOM in Angola with the overall aim to provide a background for local treatment recommendations...
May 3, 2018: Infectious Diseases of Poverty
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