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https://www.readbyqxmd.com/read/28722010/a-shape-shifting-redox-foldase-contributes-to-proteus-mirabilis-copper-resistance
#1
Emily J Furlong, Alvin W Lo, Fabian Kurth, Lakshmanane Premkumar, Makrina Totsika, Maud E S Achard, Maria A Halili, Begoña Heras, Andrew E Whitten, Hassanul G Choudhury, Mark A Schembri, Jennifer L Martin
Copper resistance is a key virulence trait of the uropathogen Proteus mirabilis. Here we show that P. mirabilis ScsC (PmScsC) contributes to this defence mechanism by enabling swarming in the presence of copper. We also demonstrate that PmScsC is a thioredoxin-like disulfide isomerase but, unlike other characterized proteins in this family, it is trimeric. PmScsC trimerization and its active site cysteine are required for wild-type swarming activity in the presence of copper. Moreover, PmScsC exhibits unprecedented motion as a consequence of a shape-shifting motif linking the catalytic and trimerization domains...
July 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28712201/case-of-xanthogranulomatous-oophoritis
#2
Bushra Khan, Aliya Begum Aziz, Rashida Ahmed
Xanthogranulomatous inflammation is characterized by destruction of the tissues of the organ involved and replacement by chronic inflammatory cells such as lymphocytes, plasma cells, occasional neutrophils with or without multinucleated or Touton giant cells. Exact aetiology is not known but the theory of infection with organisms like Proteus, E coli, and Bacteroides fragilis is most popular. Xanthogranulomatous inflammation of the female genital tract is not common and usually involves the endometrium; however, xanthogranulomatous inflammation of the ovaries is a rare entity...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28704712/multipurpose-efficacy-of-zno-nanoparticles-coated-by-the-crustacean-immune-molecule-%C3%AE-1-3-glucan-binding-protein-toxicity-on-hepg2-liver-cancer-cells-and-bacterial-pathogens
#3
Arokiadhas Iswarya, Baskaralingam Vaseeharan, Mahalingam Anjugam, Balasubramaniem Ashokkumar, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Giovanni Benelli
The effective treatment of cancer and bacterial pathogens are two key challenges in modern nanomedicine. Here, zinc oxide nanoparticles (ZnO NPs) were fabricated using the crustacean immune molecule β-1, 3- glucan binding protein (Phβ-GBP, 100kDa) purified from the heamolymph of Paratelphusa hydrodromus. β-GBP coated zinc oxide nanoparticles (Phβ-GBP-ZnO NPs) were characterized by UV-vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and high resolution-transmission electron microscopy (HR-TEM) analyses...
June 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28700747/the-association-between-ethnicity-and-vaginal-microbiota-composition-in-amsterdam-the-netherlands
#4
Hanneke Borgdorff, Charlotte van der Veer, Robin van Houdt, Catharina J Alberts, Henry J de Vries, Sylvia M Bruisten, Marieke B Snijder, Maria Prins, Suzanne E Geerlings, Maarten F Schim van der Loeff, Janneke H H M van de Wijgert
OBJECTIVE: To evaluate whether ethnicity is independently associated with vaginal microbiota (VMB) composition in women living in Amsterdam, the Netherlands, as has been shown for American women. METHODS: Women (18-34 years, non-pregnant, N = 610) representing the six largest ethnic groups (Dutch, African Surinamese, South-Asian Surinamese, Turkish, Moroccan, and Ghanaian) were sampled from the population-based HELIUS study. Sampling was performed irrespective of health status or healthcare seeking behavior...
2017: PloS One
https://www.readbyqxmd.com/read/28698042/propensity-matched-analysis-of-the-impact-of-extended-spectrum-%C3%AE-lactamase-production-on-adults-with-community-onset-escherichia-coli-klebsiella-species-and-proteus-mirabilis-bacteremia
#5
Ching-Chi Lee, Chung-Hsun Lee, Ming-Yuan Hong, Chih-Chia Hsieh, Hung-Jen Tang, Wen-Chien Ko
BACKGROUND: The presence of extended-spectrum β-lactamase (ESBL) in Escherichia coli, Klebsiella species, and Proteus mirabilis (EKP) is of great microbiological and clinical importance. The study dealing with the direct impact of ESBL producers on the outcome of patients with community-onset bacteremia is lacking. METHODS: Adults with community-onset EKP bacteremia were recruited retrospectively during a 6-year period. ESBL producers were determined according to ESBL phenotype...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28694235/clinical-benefits-of-antimicrobial-de-escalation-in-adults-with-community-onset-monomicrobial-escherichia-coli-klebsiella-species-and-proteus-mirabilis-bacteremia
#6
Ching-Chi Lee, Jiun-Ling Wang, Chung-Hsun Lee, Yuan-Pin Hung, Ming-Yuan Hong, Hung-Jen Tang, Wen-Chien Ko
The clinical benefits of an antimicrobial de-escalation strategy were compared with those of a no-switch strategy in bacteremic patients. Adults with community-onset monomicrobial Escherichia coli, Klebsiella species and Proteus mirabilis bacteremia treated empirically using broad-spectrum beta-lactams, including third-generation cephalosporins (GCs), fourth-GC or carbapenems, were treated definitively with first- or second-GCs (de-escalation group), the same regimens as empirical antibiotics (no-switch group), or antibiotics with a broader-spectrum than empirical antibiotics (escalation group)...
July 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28692914/antibiofilm-potential-of-16-oxo-cleroda-3-13-14-e-diene-15-oic-acid-and-its-five-new-%C3%AE-amino-%C3%AE-lactone-derivatives-against-methicillin-resistant-staphylococcus-aureus-and-streptococcus-mutans
#7
Anum Khalid Khan, Ayaz Ahmed, Mustafa Hussain, Ishtiaq Ahmad Khan, Syed Abid Ali, Ahsana Dar Farooq, Shaheen Faizi
The clerodane diterpenoids 16-oxo-cleroda-3, 13(14) E-diene-15 oic acid (1) and kolavenic acid (2) isolated from Polyalthia longifolia var. pendula (Linn.) were previously reported for their antimicrobial activity. Thus present study was designed to investigate the biofilm inhibiting potential of these diterpenoids (1-2) and five new lactone derivatives (3-7) of 1 against methicillin resistant Staphylococcus aureus (MRSA), Streptococcus mutans, Klebsiella pneumoniae and Proteus mirabilis. Compounds 1 and 3 at 10-20 μg/mL were found to be bacteriostatic and significantly reduced the biofilm formation and metabolically active cells of MRSA and S...
June 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28690730/septic-arthritis-of-the-pubis-symphysis-clinical-and-therapeutic-features
#8
Zeineb Alaya, Houneida Zaghouani, Walid Osman, Lassad Hassini, Nader Naouar, Mohamed Laziz Ben Ayèche, Elyès Bouajina
Septic arthritis of the pubis symphysis is rare and difficult to diagnose. The objective of our study was to describe the biological, clinical, radiological and therapeutic aspects of this disease. This is a retrospective study of 4 cases of septic arthritis of the pubic symphysis collected in the Department of Rheumatology and Orthopaedics in Sousse in Tunisia over a period of 16 years (2000-2016). Our population consists of 3 women and one men. The mean age was 47 years (18-83). Clinical signs of appeal were inflammatory groin pain, pubic pain and fever...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28676939/expression-purification-and%C3%A2-characterization-of-a-membrane-bound-d-amino-acid-dehydrogenase-from-proteus-mirabilis-jn458
#9
Jinjin Xu, Yajun Bai, Taiping Fan, Xiaohui Zheng, Yujie Cai
OBJECTIVES: To characterize a novel membrane-bound D -amino acid dehydrogenase from Proteus mirabilis JN458 (PmDAD). RESULTS: The recombinant PmDAD protein, encoding a peptide of 434 amino acids with a MW of 47.7 kDa, exhibited broad substrate specificity with D -alanine the most preferred substrate. The K m and V max values for D -alanine were 9 mM and 20 μmol min(-1) mg(-1), respectively. Optimal activity was at pH 8 and 45 °C. Additionally, this PmDAD generated H2O2 and exhibited 68 and 60% similarity with E...
July 4, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28674590/-proteus-mirabilis-septic-arthritis
#10
REVIEW
Mohammed Sbiti, Bahia Bouhamidi, Lhoussaine Louzi
Acute septic arthritis is rare. It is associated with poor prognosis in terms of mortality and morbidity. We report the case of a 61-year old patient with spontaneous Proteus mirabilis septic arthritis. He suffered from complicated diabetes associated with positive blood cultures and synovial fluid cultures. Patient's evolution was favorable thanks to early diagnosis and initiation of adequate antibiotic therapy. Proteus mirabilis septic arthritis is rare. On that basis we conducted a literature review of cases of Proteus mirabilis pyogenic arthritis to highlight the risk factors, pathogenesis, treatment and evolution of these diseases...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28671537/the-distribution-of-carbapenem-and-colistin-resistance-in-gram-negative-bacteria-from-the-tamil-nadu-region-in-india
#11
Prasanth Manohar, Thamaraiselvan Shanthini, Ramankannan Ayyanar, Bulent Bozdogan, Aruni Wilson, Ashok J Tamhankar, Ramesh Nachimuthu, Bruno S Lopes
PURPOSE: The occurrence of carbapenem- and colistin-resistance among Gram-negative bacteria is increasing worldwide. The aim of this study was to understand the distribution of carbapenem- and colistin-resistance in two areas in Tamil Nadu, India. METHODOLOGY: The clinical isolates (n=89) used in this study were collected from two diagnostic centres in Tamil Nadu, India. The bacterial isolates were screened for meropenem- and colistin-resistance. Further, resistance genes blaNDM-1, blaOXA-48-like, blaIMP, blaVIM, blaKPC, mcr-1 and mcr-2 and integrons were studied...
July 3, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28665245/prophylactic-use-of-intraoperative-vancomycin-powder-and-postoperative-infection-an-analysis-of-microbiological-patterns-in-1200-consecutive-surgical-cases
#12
Owoicho Adogwa, Aladine A Elsamadicy, Amanda Sergesketter, Victoria D Vuong, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
OBJECTIVE Wound infections following spinal surgery for deformity place a high toll on patients, providers, and the health care system. The prophylactic application of intraoperative vancomycin powder has been shown to lower the infection risk after thoracolumbar decompression and fusion for deformity correction. The purpose of this study was to assess the microbiological patterns of postoperative surgical site infections (SSIs) after prophylactic use of vancomycin powder in adult patients undergoing spinal deformity surgery...
June 30, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28663705/investigation-of-gut-microbial-communities-associated-with-indigenous-honey-bee-apis-mellifera-jemenitica-from-two-different-eco-regions-of-saudi-arabia
#13
Khalid Ali Khan, Mohammad Javed Ansari, Ahmad Al-Ghamdi, Adgaba Nuru, Steve Harakeh, Javaid Iqbal
The microbial communities associated with the alimentary tract of honey bees are very important as they help with food digestion, provide essential nutrients, protect the host from pathogens, detoxify harmful molecules, and increase host immunity. In this study, the structural diversity of the gut microbial communities of native honey bees, Apis mellifera jemenitica from two different geographical regions (Riyadh and Al-Baha) of Saudi Arabia was analyzed by culture-dependent methods and 16S ribosomal RNA (rRNA) gene sequencing...
July 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28662040/tuning-the-transcription-and-translation-of-l-amino-acid-deaminase-in-escherichia-coli-improves-%C3%AE-ketoisocaproate-production-from-l-leucine
#14
Yang Song, Jianghua Li, Hyun-Dong Shin, Long Liu, Guocheng Du, Jian Chen
α-Ketoisocaproate (KIC) is used widely in the pharmaceutical and nutraceutical industries. In previous studies, we achieved a one-step biosynthesis of KIC from l-leucine, using an Escherichia coli whole-cell biocatalyst expressing an l-amino acid deaminase (l-AAD) from Proteus vulgaris. Herein, we report the fine-tuning of l-AAD gene expression in E. coli BL21 (DE3) at the transcriptional and translational levels to improve the KIC titer. By optimizing the plasmid origin with different copy numbers, modulating messenger RNA structure downstream of the initiation codon, and designing the sequences at the ribosome binding site, we increased biocatalyst activity to 31...
2017: PloS One
https://www.readbyqxmd.com/read/28661492/quantifying-survival-in-patients-with-proteus-syndrome
#15
Julie C Sapp, Lian Hu, Jean Zhao, Ashlyn Gruber, Brian Schwartz, Dora Ferrari, Leslie G Biesecker Md
PurposeProteus syndrome is a rare mosaic overgrowth disorder that is associated with severe complications. While anecdotal data have suggested that the life span of affected patients is reduced, this has not been measured. Mortality data on rare diseases is critical for assessing treatments and other interventions.MethodsTo address this we used the clinical research records of 64 patients in a longitudinal natural history cohort at the National Institutes of Health to ascertain the data in an organized manner and estimate survival using a Kaplan-Meier approach...
June 29, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28658333/bacterial-genus-is-a-risk-factor-for-major-amputation-in-patients-with-diabetic-foot
#16
Natália Anício Cardoso, Lígia DE Loiola Cisneiros, Carla Jorge Machado, Juliana Merlin Cenedezi, Ricardo Jayme Procópio, Túlio Pinho Navarro
Objective: to evaluate whether bacterial genus is a risk factor for major amputation in patients with diabetic foot and infected ulcer. Methods: we conducted a case-control, observational study of 189 patients with infected ulcers in diabetic feet admitted to the Vascular Surgery Service of the Risoleta Tolentino Neves Hospital, from January 2007 to December 2012. The bacteriological evaluation was performed in deep tissue cultures from the lesions and amputation was considered major when performed above the foot'smiddle tarsus...
March 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28653521/-egg-shaped-macro-lithiasis
#17
T Richard, C Hauzeur, M Vanhaeverbeek
We report a 76 years-old female patient who consults for left flank pain and inflammatory biology, due to the presence of an egg-shaped 5 cm diameter macro-lithiasis. Because of the presence of a Proteus bacteriuria, the patient receives a 7 days levofloxacin treatment, before a laparoscopic resection of the kidney stone is performed. The analysis reveals a struvite lithiasis with a disorganized radial-section nuclear structure (type IVc).
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28641915/the-antimicrobial-spectrum-of-xeroform-%C3%A2
#18
David J Barillo, Anthony R Barillo, Sarah Korn, Kan Lam, Paul S Attar
INTRODUCTION/BACKGROUND: Xeroform(®) is a petrolatum-based fine mesh gauze containing 3% bismuth tribromophenate. Bismuth, similar to other metals, has antimicrobial properties. Xeroform(®) has been used for decades in burn and plastic surgery as a donor site dressing and as a covering for wounds or partial thickness burns. Despite this, the antimicrobial spectrum of Xeroform(®) remains largely unknown. We examined the in-vitro efficacy of Xeroform(®) against common burn pathogens using zone-of-inhibition methodology in a commercial research facility...
June 19, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28634338/coumarin-benzimidazole-hybrids-as-a-potent-antimicrobial-agent-synthesis-and-biological-elevation
#19
L Ravithej Singh, Srinivasa Rao Avula, Sneha Raj, Akanksha Srivastava, Gopala Reddy Palnati, C K M Tripathi, Mukesh Pasupuleti, Koneni V Sashidhara
Molecular hybridization approach is an emerging tool in drug discovery for designing new pharmacophores with biological activity. A novel, new series of coumarin-benzimidazole hybrids were designed, synthesized and evaluated for their broad spectrum antimicrobial activity. Among all the synthesized molecules, compound (E)-3-(2-1H-benzo[d]imidazol-1-yl)-1-((4-chlorobenzyl)oxy)imino)ethyl)-2H-chromen-2-one showed the most promising broad spectrum antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis and Proteus vulgaris...
June 21, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28629671/oral-immunisation-with-taishan-pinus-massoniana-pollen-polysaccharide-adjuvant-with-recombinant-lactococcus-lactis-expressing-proteus-mirabilis-ompa-confers-optimal-protection-in-mice
#20
J Zhou, K Wei, C Wang, W Dong, N Ma, L Zhu, L P Hu, H Huang, R Zhu
BACKGROUND: Proteus mirabilis poses a critical burden on the breeding industry, but no efficient vaccine is available for animals. METHOD: A recombinant Lactococcus lactis expressing the ompA of P. mirabilis was used to develop a vaccine. The mucosal and systemic immune responses of the recombinant vaccine were evaluated in mice after oral immunisation. The inhibition on P. mirabilis colonisation of vaccines was also determined. Moreover, Taishan Pinus massoniana pollen polysaccharides (TPPPS) were used as adjuvants to examine the immunomodulatory effects...
June 16, 2017: Allergologia et Immunopathologia
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