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https://www.readbyqxmd.com/read/28634338/coumarin-benzimidazole-hybrids-as-a-potent-antimicrobial-agent-synthesis-and-biological-elevation
#1
L Ravithej Singh, Srinivasa Rao Avula, Sneha Raj, Akanksha Srivastava, Gopala Reddy Palnati, C K M Tripathi, Mukesh Pasupuleti, Koneni V Sashidhara
Molecular hybridization approach is an emerging tool in drug discovery for designing new pharmacophores with biological activity. A novel, new series of coumarin-benzimidazole hybrids were designed, synthesized and evaluated for their broad spectrum antimicrobial activity. Among all the synthesized molecules, compound (E)-3-(2-1H-benzo[d]imidazol-1-yl)-1-((4-chlorobenzyl)oxy)imino)ethyl)-2H-chromen-2-one showed the most promising broad spectrum antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis and Proteus vulgaris...
June 21, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28629671/oral-immunisation-with-taishan-pinus-massoniana-pollen-polysaccharide-adjuvant-with-recombinant-lactococcus-lactis-expressing-proteus-mirabilis-ompa-confers-optimal-protection-in-mice
#2
J Zhou, K Wei, C Wang, W Dong, N Ma, L Zhu, L P Hu, H Huang, R Zhu
BACKGROUND: Proteus mirabilis poses a critical burden on the breeding industry, but no efficient vaccine is available for animals. METHOD: A recombinant Lactococcus lactis expressing the ompA of P. mirabilis was used to develop a vaccine. The mucosal and systemic immune responses of the recombinant vaccine were evaluated in mice after oral immunisation. The inhibition on P. mirabilis colonisation of vaccines was also determined. Moreover, Taishan Pinus massoniana pollen polysaccharides (TPPPS) were used as adjuvants to examine the immunomodulatory effects...
June 16, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28627093/characterization-of-thrombosis-in-patients-with-proteus-syndrome
#3
Kim M Keppler-Noreuil, Jay N Lozier, Julie C Sapp, Leslie G Biesecker
Patients with overgrowth and complex vascular malformation syndromes, including Proteus syndrome have an increased risk of thromboembolism. Proteus syndrome is a mosaic, progressive overgrowth disorder involving vasculature, skin, and skeleton, and caused by a somatic activating mutation in AKT1. We conducted a comprehensive review of the medical histories and hematologic evaluations of 57 patients with Proteus syndrome to identify potential risk factors for thrombosis. We found that six of ten patients, who were deceased, died secondary to deep venous thrombosis and/or pulmonary embolism...
June 19, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28622477/an-examination-of-factors-affecting-the-length-of-stay-in-a-palliative-care-center
#4
Metin Dincer, Kadriye Kahveci, Cihan Doger
BACKGROUND: With the increase in elderly population, life-threatening chronic diseases are increasing, simultaneously increasing the need for palliative care centers (PCCs). OBJECTIVES: To evaluate the factors affecting the length of stay (LOS) and discharge of patients from a PCC. METHODS: A retrospective scan was made of the records of patients followed up in the PCC between January 2013 and March 2016. A record was made of patient age, gender, diagnosis, conditions/comorbidities, Glasgow Coma Scale, Karnofsky Performance Scale, LOS, prognosis (exitus or surviving), percutaneous endoscopic gastrostomy (PEG), tracheostomy, mechanical ventilator, nutrition (total parenteral nutrition [TPN] or enteral nutrition), and the results of cultures taken during stay in PCCs (blood, tracheal aspirate, urine, rectal swab, wound)...
June 16, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28621711/indigenous-probiotic-lactobacillus-isolates-presenting-antibiotic-like-activity-against-human-pathogenic-bacteria
#5
Debashis Halder, Manisha Mandal, Shiv Sekhar Chatterjee, Nishith Kumar Pal, Shyamapada Mandal
BACKGROUND: Indigenous lactic acid bacteria are well known probiotics having antibacterial activity against potentially pathogenic bacteria. This study aims to characterize the curd lactobacilli for their probiotic potentiality and antagonistic activity against clinical bacteria. METHODS: Four curd samples were processed microbiologically for the isolation of lactic acid bacteria (LAB). The LAB strains obtained were identified by conventional methods: cultural aspect, gram-staining, biochemical and sugar fermentation tests...
June 16, 2017: Biomedicines
https://www.readbyqxmd.com/read/28621642/spectrum-and-antibiotic-resistance-of-uropathogens-between-2004-and-2015-in-a-tertiary-care-hospital-in-hungary
#6
András Magyar, Béla Köves, Károly Nagy, András Dobák, Vinodh Kumar Adithyaa Arthanareeswaran, Péter Bálint, Florian Wagenlehner, Péter Tenke
PURPOSE: Surveillance of the bacterial spectrum and antibiotic-resistance patterns of locally occurring uropathogens is essential to serve as a basis for empirical treatment of urinary tract infections (UTIs), as antibiotic-resistance rates may vary geographically with significant differences between countries and regions, and with time. METHODOLOGY: We retrospectively analysed all urine samples taken in the department of urology in a tertiary care hospital in Hungary from January 2004 to December 2015...
June 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28620561/patient-specific-qa-of-spot-scanning-proton-beams-using-radiochromic-film
#7
Maria F Chan, Chin-Cheng Chen, Chengyu Shi, Jingdong Li, Xiaoli Tang, Xiang Li, Dennis Mah
Radiochromic film for spot-scanning QA provides high spatial resolution and efficiency gains from one-shot irradiation for multiple depths. However, calibration can be a tedious procedure which may limit widespread use. Moreover, since there may be an energy dependence, which manifests as a depth dependence, this may require additional measurements for each patient. We present a one-scan protocol to simplify the procedure. A calibration using an EBT3 film, exposed by a 6-level step-wedge plan on a Proteus(®)PLUS proton system (IBA, Belgium), was performed at depths of 18, 20, 24cm using Plastic Water(®) (CIRS, Norfolk, VA)...
May 2017: International journal of medical physics, clinical engineering and radiation oncology
https://www.readbyqxmd.com/read/28620255/detection-of-emerging-antibiotic-resistance-in-bacteria-isolated-from-subclinical-mastitis-in-cattle-in-west-bengal
#8
Arnab Das, Chanchal Guha, Ujjwal Biswas, Partha Sarathi Jana, Amaresh Chatterjee, Indranil Samanta
AIM: The aim of this work was to detect antibiotic resistance in Gram-negative bacteria isolated from subclinical mastitis in cattle in West Bengal. MATERIALS AND METHODS: The milk samples were collected from the cattle suffering with subclinical mastitis in West Bengal. The milk samples were inoculated into the nutrient broth and incubated at 37°C. On the next day, the growth was transferred into nutrient agar and MacConkey agar. All the pure cultures obtained from nutrient agar slant were subjected to Gram-staining and standard biochemical tests...
May 2017: Veterinary World
https://www.readbyqxmd.com/read/28614382/genome-wide-transposon-mutagenesis-of-proteus-mirabilis-essential-genes-fitness-factors-for-catheter-associated-urinary-tract-infection-and-the-impact-of-polymicrobial-infection-on-fitness-requirements
#9
Chelsie E Armbruster, Valerie Forsyth-DeOrnellas, Alexandra O Johnson, Sara N Smith, Lili Zhao, Weisheng Wu, Harry L T Mobley
The Gram-negative bacterium Proteus mirabilis is a leading cause of catheter-associated urinary tract infections (CAUTIs), which are often polymicrobial. Numerous prior studies have uncovered virulence factors for P. mirabilis pathogenicity in a murine model of ascending UTI, but little is known concerning pathogenesis during CAUTI or polymicrobial infection. In this study, we utilized five pools of 10,000 transposon mutants each and transposon insertion-site sequencing (Tn-Seq) to identify the full arsenal of P...
June 14, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28612707/genetic-characteristic-of-class-1-integrons-in-proteus-mirabilis-isolates-from-urine-samples
#10
Chih-Ming Chen, Chih-Ho Lai, Hwa-Jene Wu, Lii-Tzu Wu
BACKGROUND: Proteus mirabilis is an opportunistic pathogen, commonly associated with complicated urinary tract infections (UTIs). UTIs caused by multidrug-resistant Proteus mirabilis have increased worldwide. Multidrug-resistance of Gram-negative enteric bacteria is usually associated with class 1 integrons. PURPOSES: To investigate the prevalence and characterize gene cassettes of class 1 integrons in multidrug-resistant P. mirabilis Methods: From 2006 to 2008, 314 P...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28602701/identification-and-characterization-of-new-members-of-the-sxt-r391-family-of-integrative-and-conjugative-elements-ices-in-proteus-mirabilis
#11
Luyao Bie, Hao Wu, Xin-Hua Wang, Mingyu Wang, Hai Xu
Integrative and conjugative elements (ICEs) are self-transmissible chromosomal mobile elements that play significant roles in the dissemination of antimicrobial resistance genes. Identification of the structures and functions of ICEs, particularly those in pathogens, improves understanding of the dissemination of antimicrobial resistance. This study identified new members of the sulfamethoxazole-trimethoprim (SXT)/R391 family of ICEs that could confer multi-drug resistance in the opportunistic pathogen Proteus mirabilis, characterized their genetic structures, and explored their evolutionary connection with other members of this family of ICEs...
June 8, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28599203/molecular-characterization-of-antibiotic-resistance-in-cultivable-multidrug-resistant-bacteria-from-livestock-manure
#12
Qingxiang Yang, Tiantian Tian, Tianqi Niu, Panliang Wang
Diverse antibiotic-resistance genes (ARGs) are frequently reported to have high prevalence in veterinary manure samples due to extensive use of antibiotics in farm animals. However, the characteristics of the distribution and transmission of ARGs among bacteria, especially among different species of multiple antibiotic-resistant bacteria (MARB), have not been well explored. By applying high-throughput sequencing methods, our study uncovered a vast MARB reservoir in livestock manure. The genera Escherichia, Myroides, Acinetobacter, Proteus, Ignatzschineria, Alcaligenes, Providencia and Enterococcus were the predominant cultivable MARB, with compositions of 40...
June 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28597163/shift-in-microbial-group-during-remediation-by-enhanced-natural-attenuation-rena-of-a-crude-oil-impacted-soil-a-case-study-of-ikarama-community-bayelsa-nigeria
#13
Chioma Blaise Chikere, Christopher Chibueze Azubuike, Evan Miebaka Fubara
Acute and chronic pollution of environments with crude oil does not bode well for biota living within the vicinity of polluted environments. This is due to environmental and public health concerns on the negative impact of crude oil pollution on living organisms. Enhancing microbial activities by adding nutrients and other amendments had proved effective in pollutant removal during bioremediation. This study was carried out to determine how microbial group respond during remediation by enhanced natural attenuation (RENA) during a field-scale bioremediation...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28592933/prevalence-of-biofilm-producing-aerobic-bacterial-isolates-in-burn-wound-infections-at-a-tertiary-care-hospital-in-northern-india
#14
S Asati, U Chaudhary
Burn wounds frequently get infected due to a break in skin integrity and prolonged hospitalization. Microbial flora originating from the patient's own flora colonize and infect the burn wounds. Bacterial biofilms in particular are postulated as the culprit for the development of non-healing burn wounds by inducing chronic inflammation in these patients. In the present study, 190 wound isolates obtained from patients admitted to the burn ward at the Pt. B.D. Sharma PGIMS, Rohtak, were evaluated for biofilm formation along with Antimicrobial Susceptibility Testing (AST)...
March 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28589461/association-study-of-multiple-antibiotic-resistance-and-virulence-a-strategy-to-assess-the-extent-of-risk-posed-by-bacterial-population-in-aquatic-environment
#15
Santosh Kumar Singh, Roseleen Ekka, Mitali Mishra, Harapriya Mohapatra
The present study explored the association between multiple antibiotic resistance (MAR) index and virulence index to determine what percent of environmental antibiotic-resistant (eARB) bacteria could pose threat as potential pathogen. 16srRNA-based sequencing of 113 non-duplicate isolates identified majority of them to be gram negative belonging to Enterobacter, Pseudomonas, Aeromonas, Proteus, Acinetobacter, and Klebsiella. Statistical comparison of MAR indices of the abovementioned genera indicated differences in the median values among the groups (p < 0...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28586429/hafnia-an-enterobacterial-genus-naturally-resistant-to-colistin-revealed-by-three-susceptibility-testing-methods
#16
Aurélie Jayol, Marion Saly, Patrice Nordmann, Armelle Ménard, Laurent Poirel, Véronique Dubois
Objectives: To determine the susceptibility to colistin of Hafnia alvei and Hafnia paralvei , and to compare methods for colistin resistance detection in the Hafnia genus. Methods: A collection of 25 Hafnia isolates was studied. Species were identified by using 16S rRNA gene sequencing with subsequent phylogeny analysis. Susceptibility to colistin was determined using the broth microdilution (BMD) reference method, the Phoenix automated system, the Rapid Polymyxin NP test, the Etest system and the disc diffusion method...
June 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28583153/in-vitro-antibacterial-activity-of-poly-amidoamine-g7-dendrimer
#17
Mitra Gholami, Rashin Mohammadi, Mohsen Arzanlou, Fakhraddin Akbari Dourbash, Ebrahim Kouhsari, Gharib Majidi, Seyed Mohsen Mohseni, Shahram Nazari
BACKGROUND: Nano-scale dendrimers are synthetic macromolecules that frequently used in medical and health field. Traditional anibiotics are induce bacterial resistence so there is an urgent need for novel antibacterial drug invention. In the present study seventh generation poly (amidoamine) (PAMAM-G7) dendrimer was synthesized and its antibacterial activities were evaluated against representative Gram- negative and Gram-positive bacteria. METHODS: PAMAM-G7 was synthesized with divergent growth method...
June 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28582432/in-vivo-efficacy-of-the-akt-inhibitor-arq-092-in-noonan-syndrome-with-multiple-lentigines-associated-hypertrophic-cardiomyopathy
#18
Jianxun Wang, Vasanth Chandrasekhar, Giovanni Abbadessa, Yi Yu, Brian Schwartz, Maria I Kontaridis
Noonan Syndrome with Multiple Lentigines (NSML, formerly LEOPARD syndrome) is an autosomal dominant "RASopathy" disorder manifesting in congenital heart disease. Most cases of NSML are caused by catalytically inactivating mutations in the protein tyrosine phosphatase (PTP), non-receptor type 11 (PTPN11), encoding the SH2 domain-containing PTP-2 (SHP2) protein. We previously generated knock-in mice harboring the PTPN11 mutation Y279C, one of the most common NSML alleles; these now-termed SHP2Y279C/+ mice recapitulate the human disorder and develop hypertrophic cardiomyopathy (HCM) by 12 weeks of age...
2017: PloS One
https://www.readbyqxmd.com/read/28576518/refractory-sleep-disordered-breathing-due-to-unilateral-lingual-tonsillar-hypertrophy-in-a-child-with-proteus-syndrome
#19
Courtni R Salinas, Brian A Nuyen, Aria Jafari, Javan Nation
Proteus Syndrome (PS) is a rare congenital overgrowth disease affecting bones, skin, adipose and the central nervous system. The result is asymmetric, disfiguring hypertrophy which can manifest as craniofacial dysmorphia and aerodigestive tract abnormalities. We report the case of obstructive lingual tonsillar hypertrophy resulting in residual sleep disordered breathing after adenotonsillectomy in a child with PS, a previously unrecognized manifestation of the disease. Endoscopic treatment with coblation effectively and safely treated the obstructive symptoms...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28575883/effects-of-erythropoiesis-stimulating-agents-on-intestinal-flora-in-peritoneal-fibrosis
#20
Muammer Bilici, Ibrahim Ilker Oz, Sevil Uygun Ilikhan, Ali Borazan
INTRODUCTION: This study aimed to investigate the effects of erythropoiesis-stimulating agents (ESAs) on intestinal flora in peritoneal fibrosis. METHODS AND METHODS: Twenty-four Wistar albino rats were divided into 3 groups as the control group, which received 0.9% saline (3 mL/d) intraperitoneally; the chlorhexidine gluconate (CH) group, which received 3 mL/d injections of 0.1% CH intraperitoneally, and the ESA group, which received 3 mL/d injections of 0.1% CH intraperitoneally and epoetin beta (3 doses of 20 IU/kg/wk) subcutaneously...
May 2017: Iranian Journal of Kidney Diseases
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