keyword
https://read.qxmd.com/read/38535794/the-role-of-snake-venom-disintegrins-in-angiogenesis
#1
REVIEW
Patricia Bianca Clissa, Maisa Splendore Della-Casa, Bianca Cestari Zychar, Sabri Saeed Sanabani
Angiogenesis, the formation of new blood vessels, plays a critical role in various physiological and pathological conditions. Snake venom disintegrins (SVDs) have been identified as significant regulators of this process. In this review, we explore the dual roles of SVD in angiogenesis, both as antiangiogenic agents by inhibiting integrin binding and interfering with vascular endothelial growth factors and as proangiogenic agents by enhancing integrin binding, stimulating cell migration and proliferation, and inducing neoangiogenesis...
March 1, 2024: Toxins
https://read.qxmd.com/read/38535309/advancing-personalized-medicine-by-analytical-means-selection-of-three-metabolites-that-allows-discrimination-between-glaucoma-diabetes-and-controls
#2
JOURNAL ARTICLE
David Bernal-Casas, Joan Serrano-Marín, Juan Sánchez-Navés, Josep M Oller, Rafael Franco
This paper aimed at devising an intelligence-based method to select compounds that can distinguish between open-angle glaucoma patients, type 2 diabetes patients, and healthy controls. Taking the concentration of 188 compounds measured in the aqueous humour (AH) of patients and controls, linear discriminant analysis (LDA) was used to identify the right combination of compounds that could lead to accurate diagnosis. All possibilities, using the leave-one-out approach, were considered through ad hoc programming and in silico massive data production and statistical analysis...
February 29, 2024: Metabolites
https://read.qxmd.com/read/38533730/relationship-between-running-biomechanics-and-core-temperature-across-a-competitive-road-race
#3
JOURNAL ARTICLE
Alexandra F DeJong Lempke, Michael R Szymanski, Sarah B Willwerth, Gabrielle J Brewer, Kristin E Whitney, William P Meehan, Douglas J Casa
BACKGROUND: Outdoor races introduce environmental stressors to runners, and core temperature changes may influence runners' movement patterns. This study assessed changes and determined relationships between sensor-derived running biomechanics and core temperature among runners across an 11.27-km road race. HYPOTHESIS: Core temperatures would increase significantly across the race, related to changes in spatiotemporal biomechanical measures. STUDY DESIGN: Cross-sectional cohort study...
March 27, 2024: Sports Health
https://read.qxmd.com/read/38531677/the-radiation-of-nodulated-chamaecrista-species-from-the-rainforest-into-more-diverse-habitats-has-been-accompanied-by-a-reduction-in-growth-form-and-a-shift-from-fixation-threads-to-symbiosomes
#4
JOURNAL ARTICLE
Patricia Alves Casaes, José Miguel Ferreira Dos Santos, Verônica Cordeiro Silva, Mariana Ferreira Kruschewsky Rhem, Matheus Martins Teixeira Cota, Sergio Miana de Faria, Juliana Gastaldello Rando, Euan K James, Eduardo Gross
All non-mimosoid nodulated genera in the legume subfamily Caesalpinioideae confine their rhizobial symbionts within cell wall-bound "fixation threads" (FTs). The exception is the large genus Chamaecrista in which shrubs and subshrubs house their rhizobial bacteroids more intimately within symbiosomes, whereas large trees have FTs. This study aimed to unravel the evolutionary relationships between Chamaecrista growth habit, habitat, nodule bacteroid type, and rhizobial genotype. The growth habit, bacteroid anatomy, and rhizobial symbionts of 30 nodulated Chamaecrista species native to different biomes in the Brazilian state of Bahia, a major centre of diversity for the genus, was plotted onto an ITS-TrnL-F-derived phylogeny of Chamaecrista...
March 26, 2024: Journal of Experimental Botany
https://read.qxmd.com/read/38521219/medical-history-and-preoperative-coagulation-profile-as-predictors-of-outcomes-in-elective-spinal-surgery-a-meta-analysis
#5
JOURNAL ARTICLE
Pavel S Pichardo-Rojas, Alejandro Calvillo-Ramirez, Christopher J Del Rio-Martinez, Kenzo A Fukumoto-Inukai, Diana Gonzalez-Hernandez, Ana Paulina Casas-Huesca, Cristina Villarreal-Guerrero, Siddharth Shah
No abstract text is available yet for this article.
March 21, 2024: World Neurosurgery
https://read.qxmd.com/read/38520629/estimated-incidence-of-hospitalizations-and-deaths-attributable-to-respiratory-syncytial-virus-infections-among-adults-in-germany-between-2015-and-2019
#6
JOURNAL ARTICLE
Aleksandra Polkowska-Kramek, Elizabeth Begier, Robin Bruyndonckx, Caihua Liang, Caroline Beese, Gordon Brestrich, Thao Mai Phuong Tran, Charles Nuttens, Maribel Casas, Lea Johanna Bayer, Bennet Huebbe, Worku Biyadgie Ewnetu, Juan Luis Ramirez Agudelo, Bradford D Gessner, Christof von Eiff, Gernot Rohde
INTRODUCTION: Respiratory syncytial virus (RSV) burden in adults is underestimated mainly due to unspecific symptoms and limited standard-of-care testing. We estimated the population-based incidence of hospitalization and mortality attributable to RSV among adults with and without risk factors in Germany. METHODS: Weekly counts of hospitalizations and deaths for respiratory, cardiovascular, and cardiorespiratory diseases were obtained (Statutory Health Insurance database, 2015-2019)...
March 23, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38516338/ultra-hypofractionated-one-week-locoregional-radiotherapy-for-patients-with-early-breast-cancer-acute-toxicity-results
#7
JOURNAL ARTICLE
Ivica Ratosa, Angel Montero, Raquel Ciervide, Beatriz Alvarez, Mariola García-Aranda, Jeannette Valero, Xin Chen-Zhao, Mercedes Lopez, Daniel Zucca, Ovidio Hernando, Emilio Sánchez, Miguel Angel de la Casa, Rosa Alonso, Pedro Fernandez-Leton, Carmen Rubio
PURPOSE: Moderate hypofractionated radiotherapy is the standard of care for all patients with breast cancer, irrespective of stage or prior treatments. While extreme hypofractionation is accepted for early-stage tumours, its application in irradiating locoregional lymph nodes remains controversial. MATERIALS AND METHODS: A prospective registry analysis from July 2020 to September 2023 included 276 patients with early-stage breast cancer treated with one-week ultra-hypofractionation (UHF) at 26 Gy in 5 fractions on the whole breast (58...
May 2024: Clinical and Translational Radiation Oncology
https://read.qxmd.com/read/38514660/tertiary-lymphoid-structures-and-b-cells-determine-clinically-relevant-t-cell-phenotypes-in-ovarian-cancer
#8
JOURNAL ARTICLE
Lenka Kasikova, Jana Rakova, Michal Hensler, Tereza Lanickova, Jana Tomankova, Josef Pasulka, Jana Drozenova, Katerina Mojzisova, Anna Fialova, Sarka Vosahlikova, Jan Laco, Ales Ryska, Pavel Dundr, Roman Kocian, Tomas Brtnicky, Petr Skapa, Linda Capkova, Marek Kovar, Jan Prochazka, Ivan Praznovec, Vladimir Koblizek, Alice Taskova, Hisashi Tanaka, Robert Lischke, Fernando Casas Mendez, Jiri Vachtenheim, Viola Heinzelmann-Schwarz, Francis Jacob, Iain A McNeish, Michal J Halaska, Lukas Rob, David Cibula, Sandra Orsulic, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova
Intratumoral tertiary lymphoid structures (TLSs) have been associated with improved outcome in various cohorts of patients with cancer, reflecting their contribution to the development of tumor-targeting immunity. Here, we demonstrate that high-grade serous ovarian carcinoma (HGSOC) contains distinct immune aggregates with varying degrees of organization and maturation. Specifically, mature TLSs (mTLS) as forming only in 16% of HGSOCs with relatively elevated tumor mutational burden (TMB) are associated with an increased intratumoral density of CD8+ effector T (TEFF ) cells and TIM3+ PD1+ , hence poorly immune checkpoint inhibitor (ICI)-sensitive, CD8+ T cells...
March 21, 2024: Nature Communications
https://read.qxmd.com/read/38514022/quality-of-outpatient-pediatric-palliative-care-telehealth-a-retrospective-chart-review
#9
JOURNAL ARTICLE
Elisa Williams, Catrina White, Ankona Banerjee, Melody Hellsten, Kenneth J Nobleza, Duc T Nguyen, Jessica Casas, Jill Ann Jarrell
CONTEXT: Studies suggest the feasibility and acceptability of telehealth in outpatient pediatric palliative care. However, there is a need for data that describes the implementation and quality of telehealth, relying on objective and validated measures. OBJECTIVE: We sought to compare the provision of pediatric palliative care by delivery method. METHODS: We conducted a retrospective electronic health record review of patients seen by our outpatient palliative care team over a two-year period...
March 19, 2024: Journal of Pain and Symptom Management
https://read.qxmd.com/read/38511728/post-thaw-quality-of-boar-spermatozoa-is-affected-by-ejaculate-fractions-and-extenders
#10
JOURNAL ARTICLE
Ł Zasiadczyk, K Kurpanik, L Fraser, W Kordan
The aim of this study was to investigate the effect of different extenders on the post-thaw (PT) quality of sperm originating from the sperm-rich fraction (SRF) and post-sperm-rich fraction (PSRF) of boar ejaculate. Motility and velocity parameters, analyzed using a computer-assisted semen analysis (CASA) system, and membrane integrity parameters were markedly higher in frozen-thawed (FT) spermatozoa of the SRF in both the Belstville Thawing Solution (BTS) and Androhep Plus (AHP) extenders, irrespective of the post-thaw (PT) storage time...
March 20, 2024: Polish Journal of Veterinary Sciences
https://read.qxmd.com/read/38508379/comparative-study-of-deep-lipomas-and-atypical-lipomatous-tumours-malignancy-risk-factors
#11
JOURNAL ARTICLE
L R Merino-Rueda, P Casas Ramos, E Honrado Franco, F M Izquierdo-García, L R Ramos-Pascua
BACKGROUND AND OBJECTIVES: The diagnostic suspicion of an atypical lipomatous tumour (ALT) is difficult. The aim of this study is to delve into the most controversial diagnostic aspects of the subject. MATERIAL AND METHOD: Observational, longitudinal, and retrospective study of a series of 96 deep adipose tumours (75 lipomas and 21 TLA) from 2006 to 2016: demographic, clinical, imaging and pathological variables were analysed and compared, as well as other variables related to treatment and oncological outcomes of the patients...
March 18, 2024: Revista Española de Cirugía Ortopédica y Traumatología
https://read.qxmd.com/read/38507937/human-rights-and-support-groups-to-improve-quality-of-life-self-care-and-disability-in-epilepsy-rights-and-support-groups-for-epilepsy
#12
JOURNAL ARTICLE
Felipe Agudelo-Hernández, Gloria Inés Saldarriaga Toro, Laura Inés Plata-Casas
BACKGROUND: People with epilepsy have multiple barriers to recovering their quality of life. The objective of the present study was to determine the impact of a community group intervention focused on the components of mutual aid and human rights, to improve the quality of life in people with epilepsy. METHODS: Prospective quasi-experimental study, incorporating pre- and post-intervention evaluations. There were 102 people who underwent an intervention focused on the central components of mutual aid groups (Active agency, Coping strategies, Emotion recognition and management, Problem solving, Supportive interaction, Identity construction, Trust, and Social networks) and in the QualityRights strategy...
March 16, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38504114/multicenter-integrated-analysis-of-noncoding-crispri-screens
#13
JOURNAL ARTICLE
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay-Smith, Benjamin R Doughty, Idan Gabdank, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
The ENCODE Consortium's efforts to annotate noncoding cis-regulatory elements (CREs) have advanced our understanding of gene regulatory landscapes. Pooled, noncoding CRISPR screens offer a systematic approach to investigate cis-regulatory mechanisms. The ENCODE4 Functional Characterization Centers conducted 108 screens in human cell lines, comprising >540,000 perturbations across 24.85 megabases of the genome. Using 332 functionally confirmed CRE-gene links in K562 cells, we established guidelines for screening endogenous noncoding elements with CRISPR interference (CRISPRi), including accurate detection of CREs that exhibit variable, often low, transcriptional effects...
March 19, 2024: Nature Methods
https://read.qxmd.com/read/38499951/nocturnal-vestibular-stimulation-using-a-rocking-bed-improves-a-severe-sleep-disorder-in-a-patient-with-mitochondrial-disease
#14
JOURNAL ARTICLE
Alexander Breuss, Marco Strasser, Jean-Marc Nuoffer, Andrea Klein, Eveline Perret-Hoigné, Christine Felder, Ruth Stauffer, Peter Wolf, Robert Riener, Matthias Gautschi
Mitochondrial diseases are rare genetic disorders often accompanied by severe sleep disorders. We present the case of a 12-year-old boy diagnosed with a severe primary mitochondrial disease, exhibiting ataxia, spasticity, progressive external ophthalmoplegia, cardiomyopathy and severely disrupted sleep, but no cognitive impairment. Interestingly, his parents reported improved sleep during night train rides. Based on this observation, we installed a rocking bed in the patient's bedroom and performed different interventions, including immersive multimodal vestibular, kinesthetic and auditory stimuli, reminiscent of the sensory experiences encountered during train rides...
March 18, 2024: Journal of Sleep Research
https://read.qxmd.com/read/38488510/nci-cancer-research-data-commons-lessons-learned-and-future-state
#15
JOURNAL ARTICLE
Erika Kim, Tanja M Davidsen, Brandi Davis-Dusenbery, Alexander Baumann, Angela Maggio, Zhaoyi Chen, Daoud Meerzaman, Esmeralda Casas-Silva, David Pot, Todd Pihl, John Otridge, Eve Shalley, The Crdc Program, Jill S Barnholtz-Sloan, Anthony R Kerlavage
More than ever, scientific progress in cancer research hinges on our ability to combine datasets and extract meaningful interpretations to better understand diseases and ultimately inform the development of better treatments and diagnostic tools. To enable the successful sharing and use of big data, the NCI developed the Cancer Research Data Commons (CRDC), providing access to a large, comprehensive, and expanding collection of cancer data. The CRDC is a cloud-based data science infrastructure that eliminates the need for researchers to download and store large-scale datasets by allowing them to perform analysis where data resides...
March 15, 2024: Cancer Research
https://read.qxmd.com/read/38488507/nci-cancer-research-data-commons-resources-to-share-key-cancer-data
#16
JOURNAL ARTICLE
Zhining Wang, Tanja M Davidsen, Gina R Kuffel, KanakaDurga Addepalli, Amanda Bell, Esmeralda Casas-Silva, Hayley Dingerdissen, Keyvan Farahani, Andrey Fedorov, Sharon Gaheen, Robert L Grossman, Ron Kikinis, Erika Kim, John Otridge, Todd Pihl, Melissa Porter, Henry Rodriguez, Louis M Staudt, Ratna R Thangudu, Sudha Venkatachari, Jean Claude Zenklusen, Xu Zhang, Jill S Barnholtz-Sloan, The Crdc Program, Anthony R Kerlavage
Since 2014, the National Cancer Institute (NCI) has launched a series of data commons as part of the Cancer Research Data Commons (CRDC) ecosystem housing genomic, proteomic, imaging, and clinical data to support cancer research and promote data sharing of NCI-funded studies. This review describes each data commons (Genomic Data Commons, Proteomic Data Commons, Integrated Canine Data Commons, Cancer Data Service, Imaging Data Commons, and Clinical and Translational Data Commons), including their unique and shared features, accomplishments, and challenges...
March 15, 2024: Cancer Research
https://read.qxmd.com/read/38479688/-translated-article-spanish-academy-of-dermatology-and-venereology-aedv-expert-recommendations-for-the-management-of-sexual-transmitted-parasitosis-scabies-and-pediculosis-pubis
#17
C Galván-Casas, J Ortiz-Álvarez, E Martínez-García, M Corbacho-Monné
Sexually transmitted infections are communicable diseases where the pathogen is transmitted through sexual contact. The Sexually Transmitted Infections Working Group of the Spanish Academy of Dermatology and Venereology (AEDV) is engaged in the drafting of documents to guide dermatologists and health care personnel who treat Spanish patients with these infections. This document analyzes the epidemiological, clinical, therapeutic, and control characteristics of 2 sexually transmitted parasitosis: scabies due to Sarcoptes scabiei var...
March 11, 2024: Actas Dermo-sifiliográficas
https://read.qxmd.com/read/38479163/impact-of-mediterranean-diet-promotion-on-environmental-sustainability-a-longitudinal-analysis
#18
JOURNAL ARTICLE
L Álvarez-Álvarez, F Vitelli-Storelli, M Rubín-García, S García, C Bouzas, M Ruíz-Canela, D Corella, J Salas-Salvadó, M Fitó, J A Martínez, L Tojal-Sierra, J Wärnberg, J Vioque, D Romaguera, J López-Miranda, R Estruch, F J Tinahones, J M Santos-Lozano, L Serra-Majem, A Bueno-Cavanillas, C García-Fernández, V Esteve-Luque, M Delgado-Rodríguez, M Torrego-Ellacuría, J Vidal, L Prieto, L Daimiel, R Casas, A García Arellano, S Shyam, J I González, O Castañer, A García-Rios, F Ortiz Díaz, A C Fernández, A Sánchez-Villegas, M Morey, N Cano-Ibañez, C Sorto-Sánchez, M R Bernal-López, M Bes-Rastrollo, S K Nishi, O Coltell, M D Zomeño, P J Peña-Orihuela, D V Aparicio, M A Zulet, Z Vázquez, N Babio, K A Pérez, J A Tur, V Martín-Sánchez
OBJECTIVE: This article aims to estimate the differences in environmental impact (greenhouse gas [GHG] emissions, land use, energy used, acidification and potential eutrophication) after one year of promoting a Mediterranean diet (MD). METHODS: Baseline and 1-year follow-up data from 5800 participants in the PREDIMED-Plus study were used. Each participant's food intake was estimated using validated semi-quantitative food frequency questionnaires, and the adherence to MD using the Dietary Score...
March 12, 2024: Public Health
https://read.qxmd.com/read/38476054/psychopathology-as-long-term-sequelae-of-maltreatment-and-socioeconomic-disadvantage-neurocognitive-development-perspectives
#19
JOURNAL ARTICLE
Jungmeen Kim-Spoon, Alexis Brieant, Ann Folker, Morgan Lindenmuth, Jacob Lee, Brooks Casas, Kirby Deater-Deckard
Neuroscience research underscores the critical impact of adverse experiences on brain development. Yet, there is limited understanding of the specific pathways linking adverse experiences to accelerated or delayed brain development and their ultimate contributions to psychopathology. Here, we present new longitudinal data demonstrating that neurocognitive functioning during adolescence, as affected by adverse experiences, predicts psychopathology during young adulthood. The sample included 167 participants (52% male) assessed in adolescence and young adulthood...
March 13, 2024: Development and Psychopathology
https://read.qxmd.com/read/38473321/expression-of-mitochondrial-long-non-coding-rnas-mdl1-and-mdl1as-are-good-prognostic-and-or-diagnostic-biomarkers-for-several-cancers-including-colorectal-cancer
#20
JOURNAL ARTICLE
Pablo Garrido, Adrián Casas-Benito, Ignacio M Larrayoz, Judit Narro-Íñiguez, Susana Rubio-Mediavilla, Enrique Zozaya, Alfonso Martín-Carnicero, Alfredo Martínez
Non-coding RNAs provide new opportunities to identify biomarkers that properly classify cancer patients. Here, we study the biomarker status of the mitochondrial long non-coding RNAs, MDL1 and MDL1AS. Expression of these genes was studied in public transcriptomic databases. In addition, a cohort of 69 locally advanced rectal cancer (LARC) patients with a follow-up of more than 5 years was used to determine the prognostic value of these markers. Furthermore, cell lines of colorectal (HCT116) and breast (MDA-MB-231) carcinoma were employed to study the effects of downregulating MDL1AS in vitro...
February 27, 2024: Cancers
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