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https://www.readbyqxmd.com/read/28923064/investigating-the-importance-of-the-local-food-environment-for-fruit-and-vegetable-intake-in-older-men-and-women-in-20-uk-towns-a-cross-sectional-analysis-of-two-national-cohorts-using-novel-methods
#1
S Hawkesworth, R J Silverwood, B Armstrong, T Pliakas, K Nanchahal, C Sartini, A Amuzu, G Wannamethee, J Atkins, S E Ramsay, J P Casas, R W Morris, P H Whincup, Karen Lock
BACKGROUND: Local neighbourhood environments can influence dietary behavior. There is limited evidence focused on older people who are likely to have greater dependence on local areas and may suffer functional limitations that amplify any neighbourhood impact. METHODS: Using multi-level ordinal regression analysis we investigated the association between multiple dimensions of neighbourhood food environments (captured by fine-detail, foot-based environmental audits and secondary data) and self-reported frequency of fruit and vegetable intake...
September 18, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28917208/prenatal-exposure-to-perfluoroalkyl-substances-and-birth-outcomes-in-a-spanish-birth-cohort
#2
Cyntia B Manzano-Salgado, Maribel Casas, Maria-Jose Lopez-Espinosa, Ferran Ballester, Carmen Iñiguez, David Martinez, Olga Costa, Loreto Santa-Marina, Eva Pereda-Pereda, Thomas Schettgen, Jordi Sunyer, Martine Vrijheid
BACKGROUND: Prenatal perfluorooctanoate (PFOA) exposure has been associated with reduced birth weight but maternal glomerular filtration rate (GFR) may attenuate this association. Further, this association remains unclear for other perfluoroalkyl substances (PFAS), such as perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA). We estimated associations between prenatal PFAS exposure and birth outcomes, and the influence of GFR, in a Spanish birth cohort...
September 13, 2017: Environment International
https://www.readbyqxmd.com/read/28915560/pharynx-mitochondrial-ca-2-dynamics-in-live-c-elegans-worms-during-aging
#3
Pilar Alvarez-Illera, Paloma García-Casas, Jessica Arias-Del-Val, Rosalba I Fonteriz, Javier Alvarez, Mayte Montero
Progressive decline in mitochondrial function is generally considered one of the hallmarks of aging. We have expressed a Ca(2+) sensor in the mitochondrial matrix of C. elegans pharynx cells and we have measured for the first time mitochondrial [Ca(2+)] ([Ca(2+)]M) dynamics in the pharynx of live C. elegans worms during aging. Our results show that worms stimulated with serotonin display a pharynx [Ca(2+)]M oscillatory kinetics that includes both high frequency oscillations (up to about 1Hz) and very prolonged "square-wave" [Ca(2+)]M increases, indicative of energy depletion of the pharynx cells...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28911086/large-scale-prospective-screening-of-egfr-mutations-in-the-blood-of-advanced-nsclc-patients-to-guide-treatment-decisions
#4
C Mayo-de-Las-Casas, N Jordana-Ariza, M Garzón-Ibañez, A Balada-Bel, J Bertrán-Alamillo, S Viteri-Ramírez, N Reguart, M A Muñoz-Quintana, P Lianes-Barragan, C Camps, E Jantús, J Remon-Massip, S Calabuig, D Aguiar, M L Gil, N Viñolas, A K Santos-Rodríguez, M Majem, B García-Peláez, S Villatoro, A Pérez-Rosado, J C Monasterio, E Ovalle, M J Catalán, R Campos, D Morales-Espinosa, A Martínez-Bueno, M González-Cao, X González, I Moya-Horno, A E Sosa, N Karachaliou, R Rosell, M A Molina-Vila
Background: In a significant percentage of advanced non-small-cell lung cancer (NSCLC) patients, tumor tissue is unavailable or insufficient for genetic analyses. We prospectively analyzed if circulating-free DNA (cfDNA) purified from blood can be used as a surrogate in this setting to select patients for treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Patients and methods: Blood samples were collected in 119 hospitals from 1138 advanced NSCLC patients at presentation (n = 1033) or at progression to EGFR-TKIs (n = 105) with no biopsy or insufficient tumor tissue...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28905961/correction-stereodivergent-synthesis-of-right-and-left-handed-iminoxylitol-heterodimers-and-monomers-study-of-their-impact-on-%C3%AE-glucocerebrosidase-activity
#5
Fabien Stauffert, Jenny Serra-Vinardell, Marta Gómez-Grau, Helen Michelakakis, Irene Mavridou, Daniel Grinberg, Lluïsa Vilageliu, Josefina Casas, Anne Bodlenner, Antonio Delgado, Philippe Compain
Correction for 'Stereodivergent synthesis of right- and left-handed iminoxylitol heterodimers and monomers. Study of their impact on β-glucocerebrosidase activity' by Fabien Stauffert et al., Org. Biomol. Chem., 2017, 15, 3681-3705.
September 14, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28904825/angiographic-and-epidemiological-characteristics-associated-with-aneurysm-remnants-after-microsurgical-clipping
#6
Marcos Dellaretti, Warley Carvalho da Silva Martins, Jules Carlos Dourado, Wilson Faglioni, Ricardo Souza Quadros, Vítor Vieira de Souza Moraes, Carlos Batista Alves de Souza Filho
BACKGROUND: Despite new techniques for the treatment of cerebral aneurysms, the percentage of aneurysm remnants after surgical intervention seems to be relatively constant. The objective of this study was to assess angiographic and epidemiological features associated with aneurysm remnants after microsurgical clipping. METHODS: This study was conducted from February 2009 to August 2012 on a series of 90 patients with 105 aneurysms referred to the Santa Casa of Belo Horizonte who were surgically treated and angiographically controlled...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28903376/improving-circulating-tumor-cells-enumeration-and-characterization-to-predict-outcome-in-first-line-chemotherapy-mcrpc-patients
#7
Luis León-Mateos, Helena Casas, Alicia Abalo, María Vieito, Manuel Abreu, Urbano Anido, Antonio Gómez-Tato, Rafael López, Miguel Abal, Laura Muinelo-Romay
INTRODUCTION: There is a critical need of new surrogate markers for improving the therapeutic selection and monitoring of metastatic prostate cancer patients. Nowadays clinical management of these patients is been driven by biochemical and clinical parameters without enough accuracy to allow a real personalized medicine. The present study was conducted to go insight the molecular profile of circulating tumor cells (CTCs) isolated from advanced metastatic castration-resistant prostate cancer (mCRPC) with the aim of identifying prognostic marker with potential utility for therapy selection and monitoring...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902747/exertional-heat-stroke
#8
Chelsea S Navarro, Douglas J Casa, Luke N Belval, Nathaniel S Nye
No abstract text is available yet for this article.
September 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28902268/cystic-echinococcosis-in-south-america-a-call-for-action
#9
Carlos F Pavletic, Edmundo Larrieu, Eduardo A Guarnera, Natalia Casas, Pilar Irabedra, Ciro Ferreira, Julio Sayes, Cesar M Gavidia, Eduardo Caldas, Michael Laurence Zini Lise, Melody Maxwell, Marcos Arezo, Ana Maria Navarro, Marco A N Vigilato, Ottorino Cosivi, Marcos Espinal, Victor J Del Rio Vilas
Cystic echinococcosis (CE) or hydatidosis, a parasitic zoonosis caused by a cestode of the family Taeniidae, species Echinococcus granulosus, is endemic in Argentina, Chile, Peru, Uruguay, and southern Brazil. This report presents CE figures for these five countries in 2009 - 2014 and proposes indicators to measure national control programs. Nearly 5 000 new CE cases were diagnosed annually in the five countries during the study period. The average case fatality rate was 2.9%, which suggests that CE led to approximately 880 deaths in these countries during the 6-year period...
August 21, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28895705/-complete-heart-block-and-asystole-in-a-child-with-ataxia-telangiectasia
#10
Daniel Palanca Arias, Ariadna Ayerza Casas, Mercedes Domínguez Cajal, Marta López Ramón, Lorenzo Jiménez Montañés
Ataxia-telangiectasia is a disorder characterized by cerebellar ataxia, telangiectasia, immunodeficiency, and increased predisposition to cancer susceptibility. Mutations in the ataxia telangiectasia mutated gene seem to play an important role in normal cell function and in cardiovascular remodeling. We report a case of a 14-year-old boy with ataxia-telangiectasia and high-grade B-non-Hodgkin lymphoma who remained in continuous complete remission after chemotherapy and who was admitted into our Emergency Room presenting with episodes of presyncope...
October 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28892511/the-equilibrium-between-antagonistic-signaling-pathways-determines-the-number-of-synapses-in-drosophila
#11
Sheila Jordán-Álvarez, Elena Santana, Sergio Casas-Tintó, Ángel Acebes, Alberto Ferrús
The number of synapses is a major determinant of behavior and many neural diseases exhibit deviations in that number. However, how signaling pathways control this number is still poorly understood. Using the Drosophila larval neuromuscular junction, we show here a PI3K-dependent pathway for synaptogenesis which is functionally connected with other previously known elements including the Wit receptor, its ligand Gbb, and the MAPkinases cascade. Based on epistasis assays, we determined the functional hierarchy within the pathway...
2017: PloS One
https://www.readbyqxmd.com/read/28891568/selective-antitumoural-action-of-pressurized-mango-leaf-extracts-against-minimally-and-highly-invasive-breast-cancer
#12
M T Fernández-Ponce, A López-Biedma, C Sánchez-Quesada, L Casas, C Mantell, J J Gaforio, E J Martínez de la Ossa
Mango leaf tea has been traditionally used by different cultures to reduce inflammation in the body. There is evidence that chronic inflammation increases the risk of cancer. This study investigates the antitumoural effects of pressurized mango leaf extracts on minimally (MCF7) and highly invasive (MDA-MB-231) breast cancer cells as well as on non-tumourigenic cells (MCF10). Extracts showed protective properties against oxidation and cytotoxic effects against breast cancer cell lines, causing minor damage to non-carcinogenic cells...
September 11, 2017: Food & Function
https://www.readbyqxmd.com/read/28891229/effect-of-different-mini-volume-colloid-centrifugation-configurations-on-flow-cytometrically-sorted-sperm-recovery-efficiency-and-quality-using-a-computer-assisted-semen-analyzer
#13
L B Ferré, J L Chitwood, C Fresno, H H Ortega, M E Kjelland, P J Ross
Straws of sex-sorted sperm are usually packaged at a low concentration (e.g., ~2.1 × 10(6)  sperm/ml) and cost significantly more than unsorted conventional semen from the same sire. In order to maximize the efficiency of using sex-sorted sperm under in vitro fertilization conditions, the selection of an appropriate sperm separation technique is essential. In this study, the effect of using different silane-coated silica colloid dilutions and layering configurations during centrifugation of sex-sorted sperm was examined over an extended period of incubation time...
September 11, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28887887/evaluating-the-essential-role-of-rons-in-vivo-in-exercised-human-muscle
#14
EDITORIAL
Enrique Jaimovich, Mariana Casas
An article by Margaritelis et al.,(1) (this issue) addresses an important issue in exercise physiology, as it is the actual role of reactive oxygen and nitrogen species (RONS) in exercise-induced adaptations in humans. The authors designed a procedure that allowed them to avoid the use of exogenous anti-oxidants and redox agents that will normally alter metabolism and have multiple undesired effects. We discuss here in the context of the necessary balance between the beneficial role of reactive oxygen and nitrogen species as intracellular signals for muscle adaptation and the deleterious effects of these species in oxidative stress...
September 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28885667/variations-in-retinal-nerve-fiber-layer-measurements-on-optical-coherence-tomography-after-implantation-of-trifocal-intraocular-lens
#15
Javier García-Bella, José M Martínez de la Casa, Paula Talavero González, José I Fernández-Vigo Escribano, Laura Valcarce Rial, Julián García-Feijóo
PURPOSE: To establish the changes produced after implantation of a trifocal intraocular lens (IOL) on retinal nerve fiber layer measurements performed with Fourier-domain optical coherence tomography (OCT). METHODS: This prospective study included 100 eyes of 50 patients with bilateral cataract in surgical range, no other associated ocular involvement, refractive errors between +5 and -5 spherical diopters, and less than 1.5 D of corneal astigmatism. The eyes were operated by phacoemulsification with implantation of 2 different trifocal IOLs (FineVision and AT LISA tri 839MP) in randomized equal groups...
September 5, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28884094/is-it-safe-to-use-local-anesthesia-with-adrenaline-in-hand-surgery-walant-technique
#16
Pedro José Pires Neto, Leonardo de Andrade Moreira, Priscilla Pires de Las Casas
In the past it was taught that local anesthetic should not be used with adrenaline for procedures in the extremities. This dogma is transmitted from generation to generation. Its truth has not been questioned, nor the source of the doubt. In many situations the benefit of use was not understood, because it was often thought that it was not necessary to prolong the anesthetic effect, since the procedures were mostly of short duration. After the disclosure of studies of Canadian surgeons, came to understand that the benefits went beyond the time of anesthesia...
June 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28883079/folate-dietary-insufficiency-and-folic-acid-supplementation-similarly-impair-metabolism-and-compromise-hematopoiesis
#17
Curtis J Henry, Travis Nemkov, Matias Casas-Selves, Ganna Bilousova, Vadym Zaberezhnyy, Kelly C Higa, Natalie J Serkova, Krik C Hansen, Angelo D' Alessandro, James DeGregori
While dietary folate deficiency is associated with increased risk for birth defects and other diseases, evidence suggests that supplementation with folic acid can contribute to predisposition to some diseases, including immune dysfunction and cancer. Here we show that diets supplemented with folic acid both below and above the recommended levels led to significantly altered metabolism in multiple tissues in mice. Surprisingly, both low and excessive dietary folate induced similar metabolic changes, which were particularly evident for nucleotide biosynthetic pathways in B-progenitor cells...
September 7, 2017: Haematologica
https://www.readbyqxmd.com/read/28882623/-patients-assessment-of-their-chronic-illness-care
#18
Leyre Adrián-Arrieta, Juan Manuel Casas Fernández de Tejerina
OBJECTIVE: The aim of this study is to assess the care received by chronic patients from their point of view and objectify the factors related with a better assessment of care. DESIGN: Cross-sectional descriptive study realized between September 2014 and April 2015. LOCATION: Nine Health Centers of Navarra (6 urban and 3 rural), Spain. PARTICIPANTS: Sampling opportunity of 196 patients aged over 65years presenting at least one chronic disease...
September 4, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28870446/hepacontrol-a-program-that-reduces-early-readmissions-mortality-at-60-days-and-healthcare-costs-in-decompensated-cirrhosis
#19
Betty P Morales, Ramon Planas, Ramon Bartoli, Rosa M Morillas, Margarita Sala, Irma Casas, Carolina Armengol, Helena Masnou
BACKGROUND & AIMS: Decompensated cirrhosis patients have an elevated incidence of early readmission, mortality and economic burden. The aims of HEPACONTROL were to reduce early readmission and to evaluate its impact on mortality and emergency department visits. PATIENTS AND METHODS: Quasi-experimental study with control group which compared two cohorts of patients discharged after being admitted for cirrhosis-related complications. A prospective cohort (n=80), who followed the HEPACONTROL program, which began with a follow-up examination seven days after discharge at the Hepatology Unit Day Hospital and a retrospective cohort of patients (n=112), who had been given a standard follow-up...
August 13, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28867506/gait-disturbance-and-lower-limb-pain-in-a-patient-with-pik3ca-related-disorder
#20
Gerarda Cappuccio, Marianna Alagia, Mariangela D'Anna, Carlotta Ranieri, Silvia Di Tommaso, Claudio Bruno, Chiara Fiorillo, Marina Pedemonte, Daria Loconte, Roberto Della Casa, Pietro Strisciuglio, Maria Isabella Ginocchio, Michele Pinelli, Nicoletta Resta, Nicola Brunetti-Pierri
Post-zygotic activating mutations in PIK3CA and other genes encoding members of PI3K-AKT-mTOR pathway have been found in various overgrowth syndromes that have been grouped together as PIK3CA-related overgrowth spectrum (PROS). We report a female patient with gait disturbance, leg pain, isolated macrodactyly of the foot, and mild intellectual disability. Imaging of the lower limb showed a lipoblastoma of the right thigh. A mosaic gain-of-function mutation in the catalytic domain of PIK3CA (c.3140 A > G; p...
September 1, 2017: European Journal of Medical Genetics
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