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Hydroxy methylbutyrate

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https://www.readbyqxmd.com/read/29914347/cognitive-function-is-preserved-in-aged-mice-following-long-term-%C3%AE-hydroxy-%C3%AE-methylbutyrate-supplementation
#1
Michael Munroe, Ziad S Mahmassani, Svyatoslav Dvoretskiy, Justin J Reid, Benjamin F Miller, Karyn Hamilton, Justin S Rhodes, Marni D Boppart
β-hydroxy β-methylbutyrate (HMB) is a nutritional supplement purported to enhance skeletal muscle mass and strength, as well as cognitive function in older adults. The purpose of this study was to determine the potential for long-term HMB supplementation to preserve muscle function and cognition in aged mice, as well as provide evidence of a link between vessel-associated pericyte function and outcomes. Four- (Adult/Ad) and 17 month-old (Aged/Ag) C57BL/6J mice consumed chow containing 600 mg/kg BW/day of either Ca-HMB (Ad, n=16; Ag, n=17) or Ca-Lactate (Ad, n=16; Ag, n=17) for 6 months...
June 19, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29891761/the-effects-of-beta-hydroxy-beta-methylbutyrate-free-acid-supplementation-and-resistance-training-on-oxidative-stress-markers-a-randomized-double-blind-placebo-controlled-study
#2
Hamid Arazi, Abbas Asadi, Katsuhiko Suzuki
The aim of this study was to investigate the effects of 6-week beta-hydroxy-beta methylbutyrate-free acid (HMB-FA) supplementation on oxidative stress and biochemical variables in responses to resistance training. Sixteen healthy young males participated in this study and were randomly assigned to a HMB-FA supplementation group ( n = 8) or a placebo supplementation group ( n = 8). The resistance training program was applied for 6 weeks with two sessions per week. Blood samples were collected before and after training, and 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), protein carbonyl (PC), and biochemical variables, such as alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and the numbers of total white blood cells (WBC), neutrophils, lymphocytes, and monocytes were analyzed...
June 11, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29806855/role-of-oral-nutritional-supplements-enriched-with-%C3%AE-hydroxy-%C3%AE-methylbutyrate-in-maintaining-muscle-function-and-improving-clinical-outcomes-in-various-clinical-settings
#3
A Sanz-Paris, M Camprubi-Robles, J M Lopez-Pedrosa, S L Pereira, R Rueda, M D Ballesteros-Pomar, J M Garcia Almeida, A J Cruz-Jentoft
Aging and disease-related malnutrition are well associated with loss of muscle mass and function. Muscle mass loss may lead to increased health complications and associated increase in health care costs, especially in hospitalized individuals. High protein oral nutritional supplements enriched with β-hydroxy-β-methylbutyrate (HP-ONS+HMB) have been suggested to provide benefits such as improving body composition, maintaining muscle mass and function and even decreasing mortality rates. The present review aimed to examine current evidence on the effect of HP-ONS+HMB on muscle-related clinical outcomes both in community and peri-hospitalization patients...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29804584/a-role-for-nutritional-intervention-in-addressing-the-aging-neuromuscular-junction
#4
REVIEW
Daniel G Kougias, Tapas Das, Alejandro Barranco Perez, Suzette L Pereira
The purpose of this review is to discuss the structural and physiological changes that underlie age-related neuromuscular dysfunction and to summarize current evidence on the potential role of nutritional interventions on neuromuscular dysfunction-associated pathways. Age-related neuromuscular deficits are known to coincide with distinct changes in the central and peripheral nervous system, in the neuromuscular system, and systemically. Although many features contribute to the age-related decline in neuromuscular function, a comprehensive understanding of their integration and temporal relationship is needed...
May 2018: Nutrition Research
https://www.readbyqxmd.com/read/29783624/growth-responses-of-preterm-pigs-fed-formulas-with-different-protein-levels-and-supplemented-with-leucine-or-%C3%AE-hydroxyl-%C3%AE-methylbutyrate
#5
Randal K Buddington, Scott C Howard, Harold W Lee, Karyl K Buddington
Growth after preterm birth is an important determinant of long-term outcomes. Yet, many preterm infants suffer ex utero growth retardation. We evaluated effects of leucine and the metabolite, β-hydroxy β-methylbutyrate (HMB) on growth of preterm pigs, a previously-validated translational model for preterm infants. After 48 h of parenteral nutrition preterm pigs were fed for 6 to 7 days isocaloric formulas with different levels of protein (50 or 100 g/L) with leucine (10 g/L, 76 mM) or HMB (at 1.1 g/L, 4 mM) added to stimulate protein synthesis or with alanine (6...
May 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29676656/the-effects-of-beta-hydroxy-beta-methylbutyrate-supplementation-on-recovery-following-exercise-induced-muscle-damage-a-systematic-review-and-meta-analysis
#6
Mohammad Hossein Rahimi, Hamed Mohammadi, Hesam Eshaghi, Gholamreza Askari, Maryam Miraghajani
BACKGROUND: Growing evidence suggests beta-hydroxy-beta-methylbutyrate's (HMB) positive effects on recovery following exercise-induced muscle damage (EIMD). However, findings vary substantially across studies. OBJECTIVE: A meta-analysis of randomized controlled trials was conducted to assess the effects of HMB supplementation on recovery following EIMD by assessing indirect markers of muscle damage, namely creatine kinase (CK) and lactate dehydrogenase (LDH) serum levels among healthy participants...
April 20, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29672184/oral-supplementation-with-beta-hydroxy-beta-methylbutyrate-arginine-and-glutamine-improves-lean-body-mass-in-healthy-older-adults
#7
Amy C Ellis, Gary R Hunter, Amy M Goss, Barbara A Gower
Oral intake of beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine may ameliorate muscle loss by stimulating protein synthesis and decreasing protein degradation while simultaneously decreasing inflammation. Previous studies provide evidence for improvement in body composition with dietary supplementation of these ingredients among patients with muscle-wasting diseases. The objectives of this study were to examine the effects of this amino acid mixture on lean body mass, muscle volume, and physical function among healthy older adults...
April 19, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29662554/effect-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-on-mirna-expression-in-differentiating-equine-satellite-cells-exposed-to-hydrogen-peroxide
#8
Karolina A Chodkowska, Anna Ciecierska, Kinga Majchrzak, Piotr Ostaszewski, Tomasz Sadkowski
Background: Skeletal muscle injury activates satellite cells to initiate processes of proliferation, differentiation, and hypertrophy in order to regenerate muscle fibers. The number of microRNAs and their target genes are engaged in satellite cell activation. β-Hydroxy-β-methylbutyrate (HMB) is known to prevent exercise-induced muscle damage. The purpose of this study was to evaluate the effect of HMB on miRNA and relevant target gene expression in differentiating equine satellite cells exposed to H2 O2 ...
2018: Genes & Nutrition
https://www.readbyqxmd.com/read/29627862/a-phase-ii-study-of-hmb-arg-gln-against-oral-mucositis-induced-by-chemoradiotherapy-for-patients-with-head-and-neck-cancer
#9
Tomoya Yokota, Satoshi Hamauchi, Yukio Yoshida, Takashi Yurikusa, Miho Suzuki, Aiko Yamashita, Hirofumi Ogawa, Tsuyoshi Onoe, Keita Mori, Tetsuro Onitsuka
PURPOSE: This phase II trial assessed the clinical benefit of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine (HMB/Arg/Gln) for preventing chemoradiotherapy (CRT)-induced oral mucositis (OM) in patients with head and neck cancer (HNC). METHODS: Patients with HNC receiving definitive or postoperative cisplatin-based CRT were enrolled. HMB/Arg/Gln was administered orally or per percutaneous endoscopic gastrostomy from the first day of CRT up to its completion...
April 7, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29508695/%C3%AE-hydroxy-%C3%AE-methylbutyrate-free-acid-alters-cortisol-responses-but-not-myofibrillar-proteolysis-during-a-24-h-fast
#10
Grant M Tinsley, Amy H Givan, Austin J Graybeal, Michael I Villarreal, Austin G Cross
This study was a randomised, double-blind, placebo-controlled cross-over trial examining the effects of β-hydroxy β-methylbutyrate free acid (HMB-FA) supplementation on muscle protein breakdown, cortisol, testosterone and resting energy expenditure (REE) during acute fasting. Conditions consisted of supplementation with 3 g/d HMB-FA or placebo during a 3-d meat-free diet followed by a 24-h fast. Urine was collected before and during the 24-h fast for analysis of 3-methylhistidine:creatinine ratio (3MH:CR)...
March 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29470402/cost-effectiveness-of-a-specialized-oral-nutritional-supplementation-for-malnourished-older-adult-patients-in-spain
#11
María D Ballesteros-Pomar, Diana Martínez Llinàs, Scott Goates, Rebeca Sanz Barriuso, Alejandro Sanz-Paris
Malnutrition has been related to prolonged hospital stays, and to increases in readmission and mortality rates. In the NOURISH (Nutrition effect On Unplanned Readmissions and Survival in Hospitalized patients) study, administering a high protein oral nutritional supplement (ONS) containing beta-hydroxy-beta-methylbutyrate (HP-HMB) to hospitalised older adult patients led to a significant improvement in survival compared with a placebo treatment. The aim of this study was to determine whether HP-HMB would be cost-effective in Spain...
February 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29420925/pre-exercise-%C3%AE-hydroxy-%C3%AE-methylbutyrate-free-acid-supplementation-improves-work-capacity-recovery-a-randomized-double-blinded-placebo-controlled-study
#12
Ana Luiza Matias Correia, Filipe Dinato de Lima, Martim Bottaro, Amilton Vieira, Andrew Correa da Fonseca, Ricardo M Lima
The purpose of this study was to investigate the effects of a single-dose of β-hydroxy-β-methylbutyrate free acid (HMB-FA) supplementation on muscle recovery after a high-intensity exercise bout. Twenty-three trained young males were randomly assigned to receive either a single-dose supplementation of 3g of HMB-FA (n = 12; age 22.8 ± 3.0 years) or placebo (PLA; n = 11; age 22.9 ± 3.1 years). A muscle damage protocol was applied 60 minutes after supplementation, and consisted of seven sets of 20 drop jumps from a 60-cm box with 2-min rest intervals between sets...
February 8, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29406417/is-%C3%AE-hydroxy-%C3%AE-methylbutyrate-an-effective-anabolic-agent-to-improve-outcome-in-older-diseased-populations
#13
Mariëlle P K J Engelen, Nicolaas E P Deutz
PURPOSE OF REVIEW: β-Hydroxy β-methylbutyrate (HMB) has been used for many years in athletes for muscle buildup and strength, and endurance enhancement. In recent years, its interest quickly expanded in older (diseased) populations and during (exercise) rehabilitation and recovery from hospitalization and surgery. We will discuss recent literature about HMB metabolism, its pharmacokinetics compared with the frequently used metabolite leucine, effectiveness of HMB to improve outcome in older diseased adults, and novel approaches for HMB use...
May 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29351340/inhibition-of-interleukin-6-decreases-atrogene-expression-and-ameliorates-tail-suspension-induced-skeletal-muscle-atrophy
#14
Mitsutaka Yakabe, Sumito Ogawa, Hidetaka Ota, Katsuya Iijima, Masato Eto, Yasuyoshi Ouchi, Masahiro Akishita
BACKGROUND: Interleukin-6 (IL-6) is an inflammatory cytokine. Whether systemic IL-6 affects atrogene expression and disuse-induced skeletal muscle atrophy is unclear. METHODS: Tail-suspended mice were used as a disuse-induced muscle atrophy model. We administered anti-mouse IL-6 receptor antibody, beta-hydroxy-beta-methylbutyrate (HMB) and vitamin D to the mice and examined the effects on atrogene expression and muscle atrophy. RESULTS: Serum IL-6 levels were elevated in the mice...
2018: PloS One
https://www.readbyqxmd.com/read/29300431/effects-of-protein-essential-amino-acids-b-hydroxy-b-methylbutyrate-creatine-dehydroepiandrosterone-and-fatty-acid-supplementation-on-muscle-mass-muscle-strength-and-physical-performance-in-older-people-aged-60-years-and-over-a-systematic-review-on-the-literature
#15
C Beaudart, V Rabenda, M Simmons, A Geerinck, I Araujo De Carvalho, J-Y Reginster, J Amuthavalli Thiyagarajan, O Bruyère
OBJECTIVES: The objective of this study was to perform a systematic review to investigate the effects protein, essential amino acids (EAA), β-hydroxy β-methylbutyrate (HMB), creatine, dehydroepiandrosterone (DHEA) and fatty acid supplementation on muscle mass, muscle strength and physical performance of elderly subjects. METHODS: Using the electronic databases MEDLINE and EMBASE we identified RCTs published until February 2016 which assessed the effects of these nutrient supplementation on muscle strength, muscle mass or physical performance...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29249685/effects-of-beta-hydroxy-beta-methylbutyrate-supplementation-on-strength-and-body-composition-in-trained-and-competitive-athletes-a-meta-analysis-of-randomized-controlled-trials
#16
REVIEW
Javier Sanchez-Martinez, Alejandro Santos-Lozano, Antonio Garcia-Hermoso, Kabir P Sadarangani, Carlos Cristi-Montero
OBJECTIVES: The aim of this meta-analysis was to examine the evidence for the effectiveness of beta-hydroxy-beta-methylbutyrate supplementation interventions on modification in strength and body composition in trained and competitive athletes. DESIGN: Systematic review and meta-analysis. METHODS: A systematic search was performed using three databases: MEDLINE, EBSCO and Web of Science. The analysis was restricted to randomized controlled trials that examined the effect of HMB supplementation interventions on modification in bench and leg press strength, body mass, fat-free mass and fat mass...
November 10, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29207472/effects-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-free-acid-supplementation-on-strength-power-and-hormonal-adaptations-following-resistance-training
#17
Abbas Asadi, Hamid Arazi, Katsuhiko Suzuki
BACKGROUND: β-Hydroxy-β-methylbutyrate-free acid (HMB-FA) has been ingested prior to exercise to reduce muscle damage, however the effects of HMB-FA supplementation on hormonal, strength and power adaptation are unclear. METHODS: Sixteen healthy men were matched and randomized into two groups and performed six-week resistance training while supplementing with either HMB-FA or placebo (3 g per day). The subjects were evaluated for 1 repetition maximum (1RM) bench press and leg press and vertical jump (VJ) prior to and after training intervention...
December 2, 2017: Nutrients
https://www.readbyqxmd.com/read/29182451/protein-recommendations-for-weight-loss-in-elite-athletes-a-focus-on-body-composition-and-performance
#18
REVIEW
Amy J Hector, Stuart M Phillips
There exists a large body of scientific evidence to support protein intakes in excess of the recommended dietary allowance (RDA) (0.8 g protein/kg/day) to promote the retention of skeletal muscle and loss of adipose tissue during dietary energy restriction. Diet-induced weight loss with as low as possible ratio of skeletal muscle to fat mass loss is a situation we refer to as high-quality weight loss. We propose that high-quality weight loss is often of importance to elite athletes in order to maintain their muscle (engine) and shed unwanted fat mass, potentially improving athletic performance...
March 1, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29134685/in-ovo-feeding-of-nutrients-and-its-impact-on-post-hatching-water-and-feed-deprivation-up-to-48-hr-energy-status-and-jejunal-morphology-of-chicks-using-response-surface-models
#19
M Ghanaatparast-Rashti, M Mottaghitalab, H Ahmadi
A Box-Behnken design (BBD) in a response surface methodology (RSM) was used to investigate the response of broiler chicks to in ovo feeding (IOF) of beta-hydroxy beta-methylbutyrate (HMB), dextrin and the timing of the first water and feed deprivation. On day 18th of incubation, 1,500 eggs were randomly assigned to 15 experimental runs of BBD, each with 4 replicates, as 3 levels IOF of HMB (0%, 0.5% and 1%) and dextrin (0%, 20% and 40%), and 3 levels of the first water and feed deprivation (6, 27 and 48 hr)...
April 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29110174/murine-myoblast-migration-influence-of-replicative-ageing-and-nutrition
#20
Alexander D Brown, Graeme L Close, Adam P Sharples, Claire E Stewart
Cell migration is central to skeletal muscle repair following damage. Leucine and β-Hydroxy β-methylbutyric acid (HMB) are supplements consumed for recovery from muscle damaging exercise in humans, however, their impact on muscle cell migration with age is not yet understood. We hypothesised that replicatively aged ("aged"; P46-P48) myoblasts would be less efficient at basal and supplemented repair versus parental controls ("control"; P12-P16). Aged and control myoblasts were scratch-damaged and migration velocity, directionality and distance assessed over 48 h in the absence and presence of leucine (10 mM) or HMB (10 mM) ± PI3K/Akt (LY294002 10 μM), ERK (PD98059 5 μM) or mTOR (rapamycin 0...
December 2017: Biogerontology
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