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Hydroxy methylbutyrate

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https://www.readbyqxmd.com/read/29420925/pre-exercise-%C3%AE-hydroxy-%C3%AE-methylbutyrate-free-acid-supplementation-improves-work-capacity-recovery-a-randomized-double-blinded-placebo-controlled-study
#1
Ana Luiza Matias Correia, Filipe Dinato de Lima, Martim Bottaro, Amilton Vieira, Andrew Correa da Fonseca, Ricardo M Lima
The purpose of this study was to investigate the effects of a single-dose of β-hydroxy-β-methylbutyrate free acid (HMB-FA) supplementation on muscle recovery after a high-intensity exercise bout. Twenty-three trained young males were randomly assigned to receive either a single-dose supplementation of 3g of HMB-FA (n = 12; age 22.8 ± 3.0 years) or placebo (PLA; n = 11; age 22.9 ± 3.1 years). A muscle damage protocol was applied 60 minutes after supplementation, and consisted of seven sets of 20 drop jumps from a 60-cm box with 2-min rest intervals between sets...
February 8, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29406417/is-%C3%AE-hydroxy-%C3%AE-methylbutyrate-an-effective-anabolic-agent-to-improve-outcome-in-older-diseased-populations
#2
Mariëlle P K J Engelen, Nicolaas E P Deutz
PURPOSE OF REVIEW: β-Hydroxy β-methylbutyrate (HMB) has been used for many years in athletes for muscle buildup and strength, and endurance enhancement. In recent years, its interest quickly expanded in older (diseased) populations and during (exercise) rehabilitation and recovery from hospitalization and surgery. We will discuss recent literature about HMB metabolism, its pharmacokinetics compared with the frequently used metabolite leucine, effectiveness of HMB to improve outcome in older diseased adults, and novel approaches for HMB use...
February 5, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29351340/inhibition-of-interleukin-6-decreases-atrogene-expression-and-ameliorates-tail-suspension-induced-skeletal-muscle-atrophy
#3
Mitsutaka Yakabe, Sumito Ogawa, Hidetaka Ota, Katsuya Iijima, Masato Eto, Yasuyoshi Ouchi, Masahiro Akishita
BACKGROUND: Interleukin-6 (IL-6) is an inflammatory cytokine. Whether systemic IL-6 affects atrogene expression and disuse-induced skeletal muscle atrophy is unclear. METHODS: Tail-suspended mice were used as a disuse-induced muscle atrophy model. We administered anti-mouse IL-6 receptor antibody, beta-hydroxy-beta-methylbutyrate (HMB) and vitamin D to the mice and examined the effects on atrogene expression and muscle atrophy. RESULTS: Serum IL-6 levels were elevated in the mice...
2018: PloS One
https://www.readbyqxmd.com/read/29300431/effects-of-protein-essential-amino-acids-b-hydroxy-b-methylbutyrate-creatine-dehydroepiandrosterone-and-fatty-acid-supplementation-on-muscle-mass-muscle-strength-and-physical-performance-in-older-people-aged-60-years-and-over-a-systematic-review-on-the-literature
#4
C Beaudart, V Rabenda, M Simmons, A Geerinck, I Araujo De Carvalho, J-Y Reginster, J Amuthavalli Thiyagarajan, O Bruyère
OBJECTIVES: The objective of this study was to perform a systematic review to investigate the effects protein, essential amino acids (EAA), β-hydroxy β-methylbutyrate (HMB), creatine, dehydroepiandrosterone (DHEA) and fatty acid supplementation on muscle mass, muscle strength and physical performance of elderly subjects. METHODS: Using the electronic databases MEDLINE and EMBASE we identified RCTs published until February 2016 which assessed the effects of these nutrient supplementation on muscle strength, muscle mass or physical performance...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29249685/effects-of-beta-hydroxy-beta-methylbutyrate-supplementation-on-strength-and-body-composition-in-trained-and-competitive-athletes-a-meta-analysis-of-randomized-controlled-trials
#5
REVIEW
Javier Sanchez-Martinez, Alejandro Santos-Lozano, Antonio Garcia-Hermoso, Kabir P Sadarangani, Carlos Cristi-Montero
OBJECTIVES: The aim of this meta-analysis was to examine the evidence for the effectiveness of beta-hydroxy-beta-methylbutyrate supplementation interventions on modification in strength and body composition in trained and competitive athletes. DESIGN: Systematic review and meta-analysis. METHODS: A systematic search was performed using three databases: MEDLINE, EBSCO and Web of Science. The analysis was restricted to randomized controlled trials that examined the effect of HMB supplementation interventions on modification in bench and leg press strength, body mass, fat-free mass and fat mass...
November 10, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29207472/effects-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-free-acid-supplementation-on-strength-power-and-hormonal-adaptations-following-resistance-training
#6
Abbas Asadi, Hamid Arazi, Katsuhiko Suzuki
BACKGROUND: β-Hydroxy-β-methylbutyrate-free acid (HMB-FA) has been ingested prior to exercise to reduce muscle damage, however the effects of HMB-FA supplementation on hormonal, strength and power adaptation are unclear. METHODS: Sixteen healthy men were matched and randomized into two groups and performed six-week resistance training while supplementing with either HMB-FA or placebo (3 g per day). The subjects were evaluated for 1 repetition maximum (1RM) bench press and leg press and vertical jump (VJ) prior to and after training intervention...
December 2, 2017: Nutrients
https://www.readbyqxmd.com/read/29182451/protein-recommendations-for-weight-loss-in-elite-athletes-a-focus-on-body-composition-and-performance
#7
Amy Hector, Stuart M Phillips
There exists a large body of scientific evidence to support protein intakes in excess of the recommended dietary allowance (RDA) (0.8g protein/kg/d) to promote the retention of skeletal muscle and loss of adipose tissue during dietary energy restriction. Diet-induced weight loss with as low as possible ratio of skeletal muscle to fat mass loss is a situation we refer to as high quality weight loss. We propose that high quality weight loss is often of importance to elite athletes in order to maintain their muscle (engine) and shed unwanted fat mass, potentially improving athletic performance...
November 28, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29134685/in-ovo-feeding-of-nutrients-and-its-impact-on-post-hatching-water-and-feed-deprivation-up-to-48%C3%A2-hr-energy-status-and-jejunal-morphology-of-chicks-using-response-surface-models
#8
M Ghanaatparast-Rashti, M Mottaghitalab, H Ahmadi
A Box-Behnken design (BBD) in a response surface methodology (RSM) was used to investigate the response of broiler chicks to in ovo feeding (IOF) of beta-hydroxy beta-methylbutyrate (HMB), dextrin and the timing of the first water and feed deprivation. On day 18th of incubation, 1,500 eggs were randomly assigned to 15 experimental runs of BBD, each with 4 replicates, as 3 levels IOF of HMB (0%, 0.5% and 1%) and dextrin (0%, 20% and 40%), and 3 levels of the first water and feed deprivation (6, 27 and 48 hr)...
November 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29110174/murine-myoblast-migration-influence-of-replicative-ageing-and-nutrition
#9
Alexander D Brown, Graeme L Close, Adam P Sharples, Claire E Stewart
Cell migration is central to skeletal muscle repair following damage. Leucine and β-Hydroxy β-methylbutyric acid (HMB) are supplements consumed for recovery from muscle damaging exercise in humans, however, their impact on muscle cell migration with age is not yet understood. We hypothesised that replicatively aged ("aged"; P46-P48) myoblasts would be less efficient at basal and supplemented repair versus parental controls ("control"; P12-P16). Aged and control myoblasts were scratch-damaged and migration velocity, directionality and distance assessed over 48 h in the absence and presence of leucine (10 mM) or HMB (10 mM) ± PI3K/Akt (LY294002 10 μM), ERK (PD98059 5 μM) or mTOR (rapamycin 0...
November 7, 2017: Biogerontology
https://www.readbyqxmd.com/read/29097038/impact-of-the-calcium-form-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-upon-human-skeletal-muscle-protein-metabolism
#10
D J Wilkinson, T Hossain, M C Limb, B E Phillips, J Lund, J P Williams, M S Brook, J Cegielski, A Philp, S Ashcroft, J A Rathmacher, N J Szewczyk, K Smith, P J Atherton
BACKGROUND & AIMS: β-hydroxy-β-methylbutyrate (HMB) is purported as a key nutritional supplement for the preservation of muscle mass in health, disease and as an ergogenic aid in exercise. Of the two available forms of HMB (calcium (Ca-HMB) salt or free acid (FA-HMB)) - differences in plasma bioavailability have been reported. We previously reported that ∼3 g oral FA-HMB increased muscle protein synthesis (MPS) and reduced muscle protein breakdown (MPB). The objective of the present study was to quantify muscle protein metabolism responses to oral Ca-HMB...
October 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29045254/nutritional-interventions-in-sarcopenia-where-do-we-stand
#11
Jean Woo
PURPOSE OF REVIEW: To document recent evidence regarding the role of nutrition as an intervention for sarcopenia. RECENT FINDINGS: A review of seven randomized controlled trials (RCTs) on beta-hydroxy-beta-methylbutyrate (HMB) alone on muscle loss in 147 adults showed greater muscle mass gain in the intervention group, but no benefit in muscle strength and physical performance measures. Three other review articles examined nutrition and exercise as combined intervention, and suggest enhancement of benefits of exercise by nutrition supplements (energy, protein, vitamin D)...
January 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29037326/%C3%AE-hydroxy-%C3%AE-methylbutyrate-free-acid-supplementation-may-improve-recovery-and-muscle-adaptations-after-resistance-training-a-systematic-review
#12
REVIEW
Vagner R Silva, Felipe L Belozo, Thayana O Micheletti, Marcelo Conrado, Jeffrey R Stout, Gustavo D Pimentel, Adam M Gonzalez
β-Hydroxy-β-methylbutyrate free acid (HMB-FA) has been suggested to accelerate the regenerative capacity of skeletal muscle after high-intensity exercise and attenuate markers of skeletal muscle damage. Herein a systematic review on the use of HMB-FA supplementation as an ergogenic aid to improve measures of muscle recovery, performance, and hypertrophy after resistance training was conducted. This review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We included randomized, double-blinded, placebo-controlled trials investigating the effects of HMB-FA supplementation in conjunction with resistance exercise in humans...
September 2017: Nutrition Research
https://www.readbyqxmd.com/read/29019883/bone-mineral-density-changes-of-lumbar-spine-and-femur-in-osteoporotic-patient-treated-with-bisphosphonates-and-beta-hydroxy-beta-methylbutyrate-hmb-case-report
#13
Marcin R Tatara, Witold Krupski, Barbara Majer-Dziedzic
RATIONALE: Currently available approaches to osteoporosis treatment include application of antiresorptive and anabolic agents influencing bone tissue metabolism. The aim of the study was to present bone mineral density (BMD) changes of lumbar spine in osteoporotic patient treated with bisphosphonates such as ibandronic acid and pamidronic acid, and beta-hydroxy-beta-methylbutyrate (HMB). PATIENT CONCERNS: BMD and volumetric BMD (vBMD) of lumbar spine were measured during the 6 year observation period with the use of dual-energy X-ray absorptiometry (DEXA) and quantitative computed tomography (QCT)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28986165/metabolic-phenotyping-using-kinetic-measurements-in-young-and-older-healthy-adults
#14
Nicolaas E P Deutz, John J Thaden, Gabriella A M Ten Have, Dillon K Walker, Mariëlle P K J Engelen
BACKGROUND: The aging process is often associated with the presence of sarcopenia. Although changes in the plasma concentration of several amino acids have been observed in older adults, it remains unclear whether these changes are related to disturbances in whole body production and/or interconversions. METHODS: We studied 10 healthy young (~22.7 y) and 17 older adults (~64.8 y) by administering a mixture of stable amino acid tracers in a pulse and in a primed constant infusion...
October 3, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28944645/effect-of-bcaa-supplement-timing-on-exercise-induced-muscle-soreness-and-damage-a-pilot-placebo-controlled-double-blind-study
#15
Song-Gyu Ra, Teruo Miyazaki, Ryo Kojima, Shoichi Komine, Keisuke Ishikura, Kentaro Kawanaka, Akira Honda, Yasushi Matsuzaki, Hajime Ohmori
BACKGROUND: The aim of present study was to compare the effects of branched-chain amino acid (BCAA) supplementation taken before or after exercise on delayed onset muscle soreness (DOMS) and exercise-induced muscle damage (EIMD). METHODS: Fifteen young men (aged 21.5 ± 0.4 years) were given either BCAA (9.6 g·day-1) or placebo before and after exercise (and for 3 days prior to and following the exercise day) in three independent groups: the Control group (placebo before and after exercise), the PRE group (BCAA before exercise and placebo after exercise), and the POST group (placebo before exercise and BCAA after exercise)...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28708126/the-effect-of-a-12-week-beta-hydroxy-beta-methylbutyrate-hmb-supplementation-on-highly-trained-combat-sports-athletes-a-randomised-double-blind-placebo-controlled-crossover-study
#16
Krzysztof Durkalec-Michalski, Jan Jeszka, Tomasz Podgórski
The aim of this study was to verify the effect of beta-hydroxy-beta-methylbutyrate (HMB) supplementation on physical capacity, body composition and the value of biochemical parameters in highly-trained combat sports athletes. Forty-two males highly-trained in combat sports were subjected to 12 weeks of supplementation with HMB and a placebo in a randomized, placebo controlled, double-blind crossover manner. Over the course of the experiment, aerobic and anaerobic capacity was determined, while analyses were conducted on body composition and levels of creatine kinase, lactate dehydrogenase, testosterone, cortisol and lactate...
July 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28705993/effects-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-on-skeletal-muscle-mitochondrial-content-and-dynamics-and-lipids-after-10-days-of-bed-rest-in-older-adults
#17
Robert A Standley, Giovanna Distefano, Suzette L Pereira, Min Tian, Owen J Kelly, Paul M Coen, Nicolaas E P Deutz, Robert R Wolfe, Bret H Goodpaster
Loss of muscle mass during periods of disuse likely has negative health consequences for older adults. We have previously shown that β-hydroxy-β-methylbutyrate (HMB) supplementation during 10 days of strict bed rest (BR) attenuates the loss of lean mass in older adults. To elucidate potential molecular mechanisms of HMB effects on muscle during BR and resistance training rehabilitation (RT), we examined mediators of skeletal muscle mitochondrial dynamics, autophagy and atrophy, and intramyocellular lipids...
November 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28683706/sarcopenia-what-should-a-pharmacist-know
#18
Alfonso J Cruz-Jentoft
Sarcopenia (or muscle insufficiency) is a geriatric syndrome characterized by a progressive and generalized loss of skeletal muscle mass and function which has adverse consequences, particularly physical disability, falls and death. It can develop slowly, as a chronic condition that emerges over many years, or acutely, generally due to immobilization associated with an acute disease. The physiopathology of sarcopenia is complex, and affects both the muscle and its neurological and hormonal regulation...
July 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28617846/a-metabolite-of-leucine-%C3%AE-hydroxy-%C3%AE-methylbutyrate-given-to-sows-during-pregnancy-alters-bone-development-of-their-newborn-offspring-by-hormonal-modulation
#19
Tomasz Blicharski, Ewa Tomaszewska, Piotr Dobrowolski, Monika Hułas-Stasiak, Siemowit Muszyński
The effects of dietary β-hydroxy-β-methylbutyrate (HMB) supplementation during gestation on bone, growth plate, and articular cartilage in newborns were determined. Thermal analysis of articular cartilage was performed to examine the structural changes in collagen. At day 70 of gestation, a total of 12 sows (Large White Polish breed, at the second parity) were randomly assigned to two groups, with each group receiving either a basal diet or the same diet supplemented with 0.2 g/day HMB until the 90th day...
2017: PloS One
https://www.readbyqxmd.com/read/28561638/mitigation-of-salmonella-on-pet-food-kibbles-by-using-liquid-and-powdered-3-hydroxy-3-methylbutyric-acid
#20
Anne R Huss, John C Fuller, William Centrella, Douglas L Marshall, Aiswariya Deliephan, Cassandra K Jones
In recent years, several pet food recalls have been attributed to Salmonella contamination. In addition to the negative impacts on animal health, Salmonella-contaminated pet foods have been linked to infection in humans. With that in mind, the U.S. Food and Drug Administration has set forth a zero-tolerance policy for Salmonella in pet foods. Typically, pet foods are extruded or processed at high temperatures that are sufficient to reduce pathogenic bacteria. However, the possibility for postextrusion contamination still exists...
July 2017: Journal of Food Protection
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