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https://www.readbyqxmd.com/read/29047221/selection-and-characterization-of-bacillus-thuringiensis-strains-from-northwestern-himalayas-toxic-against-helicoverpa-armigera
#1
Showkat A Lone, Abdul Malik, Jasdeep C Padaria
In this study, we present the selection and the characterization of Bacillus thuringiensis (Bt) strains with respect to their cry/cyt gene content and toxicity evaluation toward one of the most important polyphagous lepidopteran pest, Helicoverpa armigera. Fifty-six Bt isolates were obtained from 10 different regions of northwestern Himalayas, recording a total B. thuringiensis index of 0.62. Scanning electron microscopy revealed presence of bipyramidal, spherical, flat and irregular crystal shapes; SDS-PAGE analysis of spore-crystal mixtures showed the prominence of 130, 70, and 100 kDa protein bands in majority of the isolates; PCR analysis with primers for eight cry and cyt gene families and 13 cry gene subfamilies resulted in isolates showing different combinations of insecticidal genes...
October 18, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29046738/colorectal-cancer-incidence-in-path_mlh1-carriers-subjected-to-different-follow-up-protocols-a-prospective-lynch-syndrome-database-report
#2
Toni Seppälä, Kirsi Pylvänäinen, Dafydd Gareth Evans, Heikki Järvinen, Laura Renkonen-Sinisalo, Inge Bernstein, Elke Holinski-Feder, Paola Sala, Annika Lindblom, Finlay Macrae, Ignacio Blanco, Rolf Sijmons, Jacqueline Jeffries, Hans Vasen, John Burn, Sigve Nakken, Eivind Hovig, Einar Andreas Rødland, Kukatharmini Tharmaratnam, Wouter H de Vos Tot Nederveen Cappel, James Hill, Juul Wijnen, Mark Jenkins, Maurizio Genuardi, Kate Green, Fiona Lalloo, Lone Sunde, Miriam Mints, Lucio Bertario, Marta Pineda, Matilde Navarro, Monika Morak, Ian M Frayling, John-Paul Plazzer, Julian R Sampson, Gabriel Capella, Gabriela Möslein, Jukka-Pekka Mecklin, Pål Møller
BACKGROUND: We have previously reported a high incidence of colorectal cancer (CRC) in carriers of pathogenic MLH1 variants (path_MLH1) despite follow-up with colonoscopy including polypectomy. METHODS: The cohort included Finnish carriers enrolled in 3-yearly colonoscopy (n = 505; 4625 observation years) and carriers from other countries enrolled in colonoscopy 2-yearly or more frequently (n = 439; 3299 observation years). We examined whether the longer interval between colonoscopies in Finland could explain the high incidence of CRC and whether disease expression correlated with differences in population CRC incidence...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/29042446/clinical-and-metabolic-consequences-of-l-serine-supplementation-in-hereditary-sensory-and-autonomic-neuropathy-type-1c
#3
Mari Auranen, Jussi Toppila, Saranya Suriyanarayanan, Museer A Lone, Anders Paetau, Henna Tyynismaa, Thorsten Hornemann, Emil Ylikallio
Hereditary sensory neuropathy type 1 (HSAN1) may be the first genetic neuropathy amenable to a specific mechanism-based treatment, as L-serine supplementation can be used to lower the neurotoxic levels of 1-deoxysphingolipids (1-deoxySL) that cause the neurodegeneration. The treatment is so far untested in HSAN1C caused by variants in the serine palmitoyl transferase subunit 2 (SPTLC2) gene. The aim of this study was to establish whether oral L-serine lowers 1-deoxySL in a patient with HSAN1C, to perform a dose escalation to find the minimal effective dose, and to assess the safety profile and global metabolic effects of the treatment...
October 17, 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29036554/contrast-venography-vs-microwire-assisted-axillary-venipuncture-for-cardiovascular-implantable-electronic-device-implantation
#4
Jahangir Rashid Beig, Bilal A Ganai, Mohammad S Alai, Ajaz A Lone, Imran Hafeez, Mohd Iqbal Dar, Nisar A Tramboo, Hilal A Rather
Aims: This study was conducted to compare the safety and efficacy of microwire assisted technique with contrast venography guided axillary venipuncture in patients undergoing cardiovascular implantable electronic device (CIED) implantation. Methods and results: This prospective randomized study included 212 consecutive adult patients undergoing CIED implantation at our institute between 2013 and 2015. Patients were randomized to either venography guided technique (Group I; n = 105) or microwire assisted technique (Group II; n = 107) for axillary venipuncture...
September 23, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29035527/carbon-carbon-bonding-between-nitrogen-heterocyclic-carbenes-and-co2
#5
Janet E Del Bene, Ibon Alkorta, José Elguero
Ab initio MP2/aug'-cc-pVTZ calculations were performed to identify equilibrium complexes and molecules and the transition structures that interconvert them, on the potential energy surfaces of a series of seven binary systems that have nitrogen heterocyclic carbenes (NHCs) as the electron-pair donors to CO2. Seven of the NHCs form complexes stabilized by C···C tetrel bonds, and six of these seven are also stabilized by a secondary interaction between an O of CO2 and the adjacent N-H group of the carbene...
October 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29034982/bonding-scheme-and-optical-properties-in-bim2-o2-po4-m-cd-mg-zn-experimental-and-theoretical-analysis
#6
J Olchowka, O Mentré, H Kabbour, M Colmont, M Adlung, M Suta, C Wickleder
Luminescence properties of the Bi(M,M')2 PO6 (M=Mg, Zn, Cd) series have been rationalized as a function of the M element using optical spectroscopy, as well as empirical and first principles calculations. The latter yielded indirect band gaps for all compounds with energies between 2.64 and 3.62 eV, whereas luminescence measurements exhibit bright warm white emission luminescence even at room temperature assigned to Bi(3+) transitions with, for example, 22.8 % quantum yield for M=Mg. The energies of the excitation maxima are shifted with the covalent character of the Bi-O bond by inductive effects of the neighboring M-O bonds...
October 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29034891/generation-of-induced-pluripotent-stem-cells-ipsc-from-an-atrial-fibrillation-patient-carrying-a-kcna5-p-d322h-mutation
#7
Cristina Mora, Marialaura Serzanti, Alessio Giacomelli, Valentina Turco, Eleonora Marchina, Valeria Bertini, Giovanna Piovani, Giulia Savio, Lena Refsgaard, Morten Salling Olesen, Venusia Cortellini, Patrizia Dell'Era
Atrial fibrillation (AF) is the most common sustained arrhythmia associated with several cardiac risk factors, but increasing evidences indicated a genetic component. Indeed, genetic variations of the atrial specific KCNA5 gene have been identified in patients with early-onset lone AF. To investigate the molecular mechanisms underlying AF, we reprogrammed to pluripotency polymorphonucleated leukocytes isolated from the blood of a patient carrying a KCNA5 p.D322H mutation, using a commercially available non-integrating system...
October 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29034009/a-multicenter-randomized-study-of-decitabine-as-epigenetic-priming-with-induction-chemotherapy-in-children-with-aml
#8
Lia Gore, Timothy J Triche, Jason E Farrar, Daniel Wai, Christophe Legendre, Gerald C Gooden, Winnie S Liang, John Carpten, David Lee, Frank Alvaro, Margaret E Macy, Carola Arndt, Philip Barnette, Todd Cooper, Laura Martin, Aru Narendran, Jessica Pollard, Soheil Meshinchi, Jessica Boklan, Robert J Arceci, Bodour Salhia
BACKGROUND: Decitabine is a deoxycytidine nucleoside derivative inhibitor of DNA-methyltransferases, which has been studied extensively and is approved for myelodysplastic syndrome in adults but with less focus in children. Accordingly, we conducted a phase 1 multicenter, randomized, open-label study to evaluate decitabine pre-treatment before standard induction therapy in children with newly diagnosed AML to assess safety and tolerability and explore a number of biologic endpoints. RESULTS: Twenty-four patients were fully assessable for all study objectives per protocol (10 in Arm A = epigenetic priming induction, 14 in Arm B = standard induction)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29030889/activating-inert-alkali-metal-ions-by-electron-transfer-from-manganese-oxide-for-formaldehyde-abatement
#9
Jiayi Gao, Zhiwei Huang, Yaxin Chen, Jing Wan, Xiao Gu, Zhen Ma, Jianmin Chen, Xingfu Tang
Alkali metal ions often act as promoters rather than active components due to their stable outermost electronic configurations and their inert properties in heterogeneous catalysis. Herein, we activate inert alkali metal ions such as K+ and Rb+ by electron transfer from hollandite-type manganese oxide (HMO) support for HCHO oxidation. Results from synchrotron X-ray diffraction, absorption, and photoelectron spectroscopies demonstrate that the electronic density of states of single alkali metal adatoms is much higher than that of K+ or Rb+, because electrons transfer from manganese to the alkali metal adatoms through bridging lattice oxygen...
October 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29029346/botanical-compound-p-anisaldehyde-repels-larval-lone-star-tick-acari-ixodidae-and-halts-reproduction-by-gravid-adults
#10
Allan T Showler, Jessica L Harlien
The lone star tick, Amblyomma americanum (L.), widely distributed across eastern, southeastern, and midwestern regions of the United States and south into Mexico, is an obligate blood feeder that attaches to three hosts during the larval, nymphal, and adult stages. White-tailed deer and wild turkey are common hosts, as well as a wide variety of other avian and mammalian hosts. Amblyomma americanum is the most frequently reported species of tick to bite humans in the southeastern and southcentral United States, and it can transmit diseases that include erhlichiosis, rickettsiosis, tularemia, and protozoan infections...
October 4, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29028824/the-association-between-serum-brain-derived-neurotrophic-factor-and-a-cluster-of-cardiovascular-risk-factors-in-adolescents-the-champs-study-dk
#11
Natascha Holbæk Pedersen, Jakob Tarp, Lars Bo Andersen, Anne Kær Gejl, Tao Huang, Lone Peijs, Anna Bugge
BACKGROUND AND OBJECTIVE: Cardiovascular disease and type 2 diabetes pose a global health burden. Therefore, clarifying the pathology of these risk factors is essential. Previous studies have found positive and negative associations between one or more cardiovascular risk factors and brain-derived neurotrophic factor (BDNF) probably due to diverse methodological approaches when analysing peripheral BDNF levels. Moreover, only a few studies have been performed in youth populations. Consequently, the main objective of this study was to examine the association between serum BDNF and a composite z-score consisting of six cardiovascular risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/29028807/ulcerative-colitis-crohn-s-disease-and-irritable-bowel-syndrome-have-different-profiles-of-extracellular-matrix-turnover-which-also-reflects-disease-activity-in-crohn-s-disease
#12
Joachim Høg Mortensen, Tina Manon-Jensen, Michael Dam Jensen, Per Hägglund, Lone Gabriels Klinge, Jens Kjeldsen, Aleksander Krag, Morten Asser Karsdal, Anne-Christine Bay-Jensen
BACKGROUND: Increased protease activity is a key pathological feature of inflammatory bowel disease (IBD). However, the differences in extracellular matrix remodelling (ECM) in Crohn's disease (CD) and ulcerative colitis (UC) are not well described. An increased understanding of the inflammatory processes may provide optimized disease monitoring and diagnostics. We investigated the tissue remodelling in IBD and IBS patients by using novel blood-based biomarkers reflecting ECM remodelling...
2017: PloS One
https://www.readbyqxmd.com/read/29027840/male-factor-infertility-and-risk-of-multiple-sclerosis-a-register-based-cohort-study
#13
Clara Helene Glazer, Sandra Søgaard Tøttenborg, Aleksander Giwercman, Elvira Vaclavik Bräuner, Michael L Eisenberg, Ditte Vassard, Melinda Magyari, Anja Pinborg, Lone Schmidt, Jens Peter Bonde
BACKGROUND: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS. OBJECTIVE: To study the association between male factor infertility and prevalent as well as incident MS. METHOD: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29025141/how-is-it-best-to-deliver-care-in-acute-medical-units-a-systematic-review
#14
L E M Reid, A J F Crookshanks, M C Jones, Z J Morrison, N I Lone, C J Weir
The majority of medical patients presenting to hospital in the UK are cared for in acute medical units (AMUs). Such units are also increasingly present internationally. Care delivery varies across units: this review aims to examine the evidence for how best to deliver AMU care.Six electronic databases and grey literature were searched. Inclusion criteria comprised interventions applied to undifferentiated patients in AMU settings. All studies were quality assessed. A narrative approach was undertaken.Nine studies, all conducted in the UK or Ireland, evaluated 1...
August 4, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29025019/differing-molecular-response-of-young-and-advanced-maternal-age-human-oocytes-to-ivm
#15
J M Reyes, E Silva, J L Chitwood, W B Schoolcraft, R L Krisher, P J Ross
STUDY QUESTION: What effect does maternal age have on the human oocyte's molecular response to in vitro oocyte maturation? SUMMARY ANSWER: Although polyadenylated transcript abundance is similar between young and advanced maternal age (AMA) germinal vesicle (GV) oocytes, metaphase II (MII) oocytes exhibit a divergent transcriptome resulting from a differential response to in vitro oocyte maturation. WHAT IS KNOWN ALREADY: Microarray studies considering maternal age or maturation stage have shown that either of these factors will affect oocyte polyadenylated transcript abundance in human oocytes...
September 15, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29020195/impact-of-pneumococcal-conjugate-vaccines-on-pneumonia-hospitalizations-in-high-and-low-income-subpopulations-in-brazil
#16
Joshua L Warren, Kayoko Shioda, Esra Kürüm, Cynthia Schuck-Paim, Roger Lustig, Robert J Taylor, Lone Simonsen, Daniel M Weinberger
Background: Pneumococcal conjugate vaccines (PCVs) are being used worldwide. A key question is whether the impact of PCVs on pneumonia is similar in low- and high-income populations. However, most low-income countries, where the burden of disease is greatest, lack reliable data that can be used to evaluate the impact. Data from middle-income countries that have both low- and high-income subpopulations can provide a proxy measure for the impact of the vaccine in low-income countries. Methods: We evaluated the impact of PCV10 on hospitalizations for all-cause pneumonia in Brazil, a middle-income country with localities that span a broad range of human development index (HDI) levels...
July 22, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29018125/more-than-enzymes-that-make-or-break-cyclic-di-gmp-local-signaling-in-the-interactome-of-ggdef-eal-domain-proteins-of-escherichia-coli
#17
Olga Sarenko, Gisela Klauck, Franziska M Wilke, Vanessa Pfiffer, Anja M Richter, Susanne Herbst, Volkhard Kaever, Regine Hengge
The bacterial second messenger bis-(3'-5')-cyclic diguanosine monophosphate (c-di-GMP) ubiquitously promotes bacterial biofilm formation. Intracellular pools of c-di-GMP seem to be dynamically negotiated by diguanylate cyclases (DGCs, with GGDEF domains) and specific phosphodiesterases (PDEs, with EAL or HD-GYP domains). Most bacterial species possess multiple DGCs and PDEs, often with surprisingly distinct and specific output functions. One explanation for such specificity is "local" c-di-GMP signaling, which is believed to involve direct interactions between specific DGC/PDE pairs and c-di-GMP-binding effector/target systems...
October 10, 2017: MBio
https://www.readbyqxmd.com/read/29016832/contemporary-stroke-prevention-strategies-in-11%C3%A2-096-european-patients-with-atrial-fibrillation-a-report-from-the-eurobservational-research-programme-on-atrial-fibrillation-eorp-af-long-term-general-registry
#18
Giuseppe Boriani, Marco Proietti, Cécile Laroche, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana Potpara, Gheorghe-Andrei Dan, Zbigniew Kalarus, Igor Diemberger, Luigi Tavazzi, Aldo P Maggioni, Gregory Y H Lip
Aims: Contemporary data regarding atrial fibrillation (AF) management and current use of oral anticoagulants (OACs) for stroke prevention are needed. Methods and results: The EURObservational Research Programme on AF (EORP-AF) Long-Term General Registry analysed consecutive AF patients presenting to cardiologists in 250 centres from 27 European countries. From 2013 to 2016, 11 096 patients were enrolled (40.7% female; mean age 69 ± 11 years). At discharge, OACs were used in 9379 patients (84...
September 14, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28992839/-symptomatic-zinc-deficiency-in-a-breast-fed-infant
#19
EDITORIAL
Lone Hvid, Gitte Zachariassen, Karina Dyrvig Honoré, Anne Birgitte Simonsen
Nutrition containing zinc is of special practical importance in infants and children. Perinatal zinc deficiency manifestations include erosive dermatitis, alopecia, diarrhoea, central nervous system dysfunction and immune system deficiency. We present a case story of an ex-preterm, exclusively breast-fed infant who presented with irritability, clinical signs of infection, an atypical rash and signs of oral candidiasis. Blood tests showed low plasma levels of zinc and subsequent analysis showed reduced zinc levels in the breast milk...
October 9, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28991474/why-do-cumulene-ketones-kink
#20
Frank Weinhold
We employ ab initio and density functional methods to investigate the equilibrium structure and vibrational frequencies of extended cumulene monoketones [CH2=(C=)mO] and diketones [O=(C=)mO], in order to elucidate the electronic origin of the curious "kinked'" spine geometries that are common in such species. The dominant role of symmetry-breaking nO(π)-σ*CC interactions between the p-type lone pair of the terminal oxygen and adjacent unfilled CC antibonding orbital is demonstrated by NBO 2nd-order delocalization energies, Fock matrix deletions, and natural resonance theory (NRT) descriptors, showing the general connection between cumulene kinking and CC bond-breaking reactions that split off CO...
October 9, 2017: Journal of Organic Chemistry
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