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https://www.readbyqxmd.com/read/27920933/crystal-structure-of-1-3-bis-3-tert-butyl-2-hy-droxy-5-methyl-benz-yl-1-3-diazinan-5-ol-monohydrate
#1
Augusto Rivera, Ingrid Miranda-Carvajal, Jaime Ríos-Motta, Michael Bolte
In the title hydrate, C28H42N2O3·H2O, the central 1,3-diazinan-5-ol ring adopts a chair conformation with the two benzyl substituents equatorial and the lone pairs of the N atoms axial. The dihedral angle between the aromatic rings is 19.68 (38)°. There are two intra-molecular O-H⋯N hydrogen bonds, each generating an S(6) ring motif. In the crystal, classical O-H⋯O hydrogen bonds connect the 1,3-diazinane and water mol-ecules into columns extending along the b axis. The crystal structure was refined as a two-component twin with a fractional contribution to the minor domain of 0...
September 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27920089/world-endometriosis-society-consensus-on-the-classification-of-endometriosis
#2
Neil P Johnson, Lone Hummelshoj, G David Adamson, Jörg Keckstein, Hugh S Taylor, Mauricio S Abrao, Deborah Bush, Ludwig Kiesel, Rulla Tamimi, Kathy L Sharpe-Timms, Luk Rombauts, Linda C Giudice
STUDY QUESTION: What is the global consensus on the classification of endometriosis that considers the views of women with endometriosis? SUMMARY ANSWER: We have produced an international consensus statement on the classification of endometriosis through systematic appraisal of evidence and a consensus process that included representatives of national and international, medical and non-medical societies, patient organizations, and companies with an interest in endometriosis...
December 5, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27916581/use-of-a-tick-borne-disease-manual-increases-accuracy-of-tick-identification-among-primary-care-providers-in-lyme-disease-endemic-areas
#3
Amber D Butler, Meredith L Carlson, Christina A Nelson
Given the high incidence of tick bites and tick-borne diseases in the United States, it is important for primary care providers to recognize common ticks and the pathogens they may transmit. If a patient has removed and saved an attached tick, identifying the tick helps guide clinical management and determine whether antibiotic prophylaxis for Lyme disease is appropriate. To investigate providers' ability to recognize common ticks and the pathogens they may transmit, we asked 76 primary care providers from Lyme disease endemic areas to identify the common name or genus of preserved ticks found in their area...
November 23, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27914584/outcome-of-poorly-functioning-kidneys-secondary-to-pujo-preserved-by-pyeloplast
#4
Yasir Ahmad Lone, Ram Samujh, Anish Bhattacharya, Ravi Prakash Kanojia
AIMS: To study the intermediate term to long-term functional status of kidneys with split renal function(SRF) <15% secondary to PUJO which are preserved by pyeloplasty and to find out whether these kidneys can recover or eventually need nephrectomy. METHODS: 24 patients with SRF<15% and undergoing pyeloplasty with or without prior percutaneous nephrostomy (PCN) were studied. Those with associated VUR, B/L disease and redo pyeloplasties were excluded. Follow up USG and EC scan were done at 3, 9 and 18months and yearly thereafter to document functional status after surgery...
November 26, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27912852/old-age-and-vulnerability-between-first-second-and-third-person-perspectives-ethnographic-explorations-of-aging-in-contemporary-denmark
#5
Lone Grøn
This paper is based on an ethnographic fieldwork aimed at exploring ethnographically how vulnerability in old age is perceived and experienced in contemporary Denmark. The fieldwork showed remarkable differences between two phases of the fieldwork: the first addressing vulnerability from the "outside" through group interviews with professionals, leaders and older people who were not (yet) vulnerable; and the second from the "inside" through more in depth fieldwork with older people who in diverse ways could be seen as vulnerable...
December 2016: Journal of Aging Studies
https://www.readbyqxmd.com/read/27912742/secular-trends-and-correlates-of-physical-activity-the-troms%C3%A3-study-1979-2008
#6
Bente Morseth, Bjarne K Jacobsen, Nina Emaus, Tom Wilsgaard, Lone Jørgensen
BACKGROUND: The aim was to describe secular trends in leisure time physical activity (LTPA) and work related physical activity (WPA) from 1979 to 2008. Additionally, we explored potential cross-sectional and longitudinal correlates of LTPA and WPA. METHODS: Data are collected from 34,898 individuals (49.7% men) aged >20 years who participated in at least one Tromsø Study survey between 1979 and 2008. In each survey, the participants completed a self-administered questionnaire and underwent physical examinations...
December 3, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27909080/ankylosing-spondylitis-versus-nonradiographic-axial-spondyloarthritis-comparison-of-tumor-necrosis-factor-inhibitor-effectiveness-and-effect-of-hla-b27-status-an-observational-cohort-study-from-the-nationwide-danbio-registry
#7
Bente Glintborg, Inge J Sørensen, Mikkel Østergaard, Lene Dreyer, Abdiweli A Mohamoud, Niels S Krogh, Oliver Hendricks, Lis S Andersen, Johnny L Raun, Marcin R Kowalski, Laura Danielsen, Randi Pelck, Henrik Nordin, Jens K Pedersen, Dorte G A Kraus, Susan R Christensen, Inger M J Hansen, Jakob Esbesen, Annette Schlemmer, Anne G Loft, Nabil Al Chaer, Lone Salomonsen, Merete L Hetland
OBJECTIVE: To compare baseline disease activity and treatment effectiveness in biologic-naive patients with nonradiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) who initiate tumor necrosis factor inhibitor (TNFi) treatment and to study the role of potential confounders (e.g., HLA-B27 status). METHODS: Observational cohort study based on prospectively registered data in the nationwide DANBIO registry. We used Kaplan-Meier plots, Cox, and logistic regression analyses to study the effect of diagnosis (nr-axSpA vs AS) and potential confounders (sex/age/start yr/HLA-B27/disease duration/TNFi-type/smoking/baseline disease activity) on TNFi adherence and response [e...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27907847/factors-associated-with-re-entry-to-out-of-home-care-among-children-in-england
#8
Louise Mc Grath-Lone, Lorraine Dearden, Katie Harron, Bilal Nasim, Ruth Gilbert
Exiting and re-entering out-of-home care (OHC) is considered a disruption to permanence which may have long-lasting, negative consequences for children due to a lack of stability and continuity. Each year approximately one-third of children in OHC in England exit, but information is lacking on rates of re-entries and associated factors. Using national administrative data, we calculated rates of re-entry among children exiting OHC from 2007 to 2012, identified key child and care factors associated with re-entry using Cox proportional hazards modelling, and developed a simple probability calculator to estimate which groups of children are most likely to re-enter OHC within three months...
November 28, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27905598/dehydro-oxazole-thiazole-and-imidazole-radicals-insights-into-the-electronic-structure-stability-and-reactivity-aspects
#9
Anamika Mukhopadhyay, Lilit Jacob, Sugumar Venkataramani
DFT (U)B3LYP/cc-pVTZ and (U)M06-2X/cc-pVTZ and multireference CASSCF/cc-pVTZ level of theories have been used to investigate the electronic structure of isomeric dehydrooxazole (1b-d, 3 isomers), dehydrothiazole (2b-d, 3 isomers) and dehydroimidazole (3a-d, 4 isomers) radicals. The ground state electronic structure of each radical isomer has been confirmed by predicting their doublet excited state structure and calculating the adiabatic energy difference. The stability order of the individual isomeric radicals has been estimated through the comparison of absolute energies...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27904904/clinical-evaluation-of-glycopegylated-recombinant-fviii-efficacy-and-safety-in-severe-haemophilia-a
#10
Paul Giangrande, Tatiana Andreeva, Pratima Chowdary, Silke Ehrenforth, Hideji Hanabusa, Frank W G Leebeek, Steven R Lentz, Laszlo Nemes, Lone Hvitfeldt Poulsen, Elena Santagostino, Chur Woo You, Wan Hui Ong Clausen, Peter G Jönsson, Johannes Oldenburg
Turoctocog alfa pegol (N8-GP) is a novel glycoPEGylated extended half-life recombinant factor VIII (FVIII) product developed for prophylaxis and treatment of bleeds in patients with haemophilia A, to enable higher activity levels with less frequent injections compared with standard FVIII products. This phase III (NCT01480180), multinational, open-label, non-randomised trial evaluated the safety and clinical efficacy of N8-GP when administered for treatment of bleeds and for prophylaxis, in previously treated patients aged ≥12 years with severe haemophilia A...
December 1, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27900914/try-to-be-a-skilled-companion-to-older-people-this-christmas
#11
(no author information available yet)
Nurses are usually busy at this time of year, as pressure on health and social care services rises for the holiday season. Yet for some frail, older people, especially those who have outlived many of their generation of family and friends, this can be an especially lonely time.
November 30, 2016: Nursing Older People
https://www.readbyqxmd.com/read/27900899/if-you-know-a-lonely-older-person-try-tea-and-empathy
#12
Mary Rance
One third of people say they are aware of lonely older people in their communities and one in four are aware but do not know how to offer adequate help. These are two of the startling findings from our latest research.
November 30, 2016: Nursing Older People
https://www.readbyqxmd.com/read/27900831/cooperation-of-three-chromophores-generates-the-water-resistant-nitrate-nonlinear-optical-material-bi3-teo6-oh-no3-2
#13
Sangen Zhao, Yi Yang, Yaoguo Shen, Bingqing Zhao, Lina Li, Chengmin Ji, Zhenyue Wu, Daqiang Yuan, Zheshuai Lin, Maochun Hong, Junhua Luo
Nitrates have long been ignored for practical uses as nonlinear optical (NLO) materials because they are usually very easy to dissolve in water; despite this, the π-conjugated [NO3 ](-) is among the most desirable NLO-active structural units. The cooperation of three structural chromophores, namely, Bi3 O6 OH short chains with 6s(2) lone pair electrons, distorted TeO6 octahedra with d(10) electrons, and π-conjugated [NO3 ](-) triangles, generates a new nitrate NLO material, Bi3 TeO6 OH(NO3 )2 , which exhibits an enhanced phase-matchable NLO response of three times that of KH2 PO4 (3×KH2 PO4 ), exceeding those of most nitrate NLO materials...
November 30, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27900790/revealing-germylene-compounds-to-attain-superbasicity-with-sigma-donor-substituents-a-density-functional-theory-study
#14
Bishwajit Ganguly, Abul Kalam Biswas
This study reports for the first time that compounds of Ge (II) can function as superbases. Two B(N=PiPr3)2 groups attached to a germanium (II) center show a gas phase proton affinity of 296.2 kcal/mol, close to the range of a hyperbase as revealed by B3LYP-D3/6-31G(2d,p) level of theory. These DFT calculations showed better agreement of geometrical parameters for the reported stable germylene compound 1 than previously reported calculations at the B3LYP/6-31G(2d,p) and PBE/DZP level of theory. A systematic study performed with different substitutions of Ge(II) revealed that such system can achieve basicity close to a hyperbase...
November 30, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27899227/challenges-to-estimating-vaccine-impact-using-hospitalization-data
#15
Cynthia Schuck-Paim, Robert J Taylor, Lone Simonsen, Roger Lustig, Esra Kürüm, Christian A W Bruhn, Daniel M Weinberger
Because the real-world impact of new vaccines cannot be known before they are implemented in national programs, post-implementation studies at the population level are critical. Studies based on analysis of hospitalization rates of vaccine-preventable outcomes are typically used for this purpose. However, estimates of vaccine impact based on hospitalization data are particularly prone to confounding, as hospitalization rates are tightly linked to changes in the quality, access and use of the healthcare system, which often occur simultaneously with introduction of new vaccines...
November 26, 2016: Vaccine
https://www.readbyqxmd.com/read/27895282/liberalization-in-the-danish-waste-sector-an-institutional-perspective
#16
Lone Kørnøv, Amanda Louise Hill, Ole Busck, Søren Løkke
The push for creating a more competitive and liberalized system for traditional public services, including waste management, has been on the European agenda since the late 1980s. In 2008, changes were made in EU waste legislation allowing source-separated industrial/commercial waste that is suitable for incineration to be traded within the European market. This change has had broad implications for the Danish waste sector, which is characterized by institutionalized municipal control with all streams of waste and municipal ownership of the major treatment facilities allowing the municipal sector to integrate combustible waste in local heat and power generation...
December 2016: Waste Management & Research
https://www.readbyqxmd.com/read/27892212/loneliness-could-be-a-predictor-for-alzheimer-s-disease
#17
(no author information available yet)
Lonely people have an increased risk of developing Alzheimer's disease because they have high levels of the protein amyloid in the brain, suggest US researchers.
November 23, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27891543/dynamic-neighbouring-participation-of-nitrogen-lone-pairs-on-the-chromogenic-behaviour-of-trans-bis-salicylaldiminato-pt-ii-coordination-platforms
#18
Takumi Hashimoto, Kanako Fukumoto, Ngoc Ha-Thu Le, Tatsuya Matsuoka, Soichiro Kawamorita, Naruyoshi Komiya, Takeshi Naota
The participation of neighbouring nitrogen lone pairs in the chromogenic control of trans-bis(salicylaldiminato)Pt(ii) platforms was examined, using newly designed Pt analogues bearing salicylaldehyde hydrazone ligands. A series of non-vaulted and vaulted Pt complexes (1-5) with salicylaldehyde hydrazones as trans-coordinated bidentate ligands were synthesized and characterized with regard to the chromogenic behaviour of the trans-bis(salicylaldiminato)Pt(ii) coordination platforms. X-ray diffraction and 2D NMR data demonstrated that, in the case of the non-vaulted N-monomethyl complexes 1, there was significant participation of neighbouring N(2) lone pairs in the d-π conjugation of the trans-bis(salicylaldiminato)Pt(ii) platforms owing to conformational fixation arising from intramolecular hydrogen bonding...
November 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27890977/health-and-socioeconomic-status-of-the-elderly-people-living-in-hilly-areas-of-pakhribas-kosi-zone-nepal
#19
Ankit Amar Gupta, Amrit Kumar Lall, Aditi Das, Anshu Saurav, Abnish Nandan, Deepa Shah, Anand Agrahari, Deepak Kumar Yadav
BACKGROUND: The rising geriatric population is facing significant health and social problems in the developing world that are impacting the quality of their lives. OBJECTIVE: The study describes the general health status and the socioeconomic characteristics of the elderly people of Pakhribas village development committee (VDC) of Eastern Nepal. MATERIALS AND METHODS: Descriptive cross-sectional study was carried out targeting the people aged 60 years and above in the sample area using a semi-structured questionnaire and convenient sampling to get the required sample size...
October 2016: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/27889186/circadian-homeostasis-of-liver-metabolism-suppresses-hepatocarcinogenesis
#20
Nicole M Kettner, Horatio Voicu, Milton J Finegold, Cristian Coarfa, Arun Sreekumar, Nagireddy Putluri, Chinenye A Katchy, Choogon Lee, David D Moore, Loning Fu
Chronic jet lag induces spontaneous hepatocellular carcinoma (HCC) in wild-type mice following a mechanism very similar to that observed in obese humans. The process initiates with non-alcoholic fatty liver disease (NAFLD) that progresses to steatohepatitis and fibrosis before HCC detection. This pathophysiological pathway is driven by jet-lag-induced genome-wide gene deregulation and global liver metabolic dysfunction, with nuclear receptor-controlled cholesterol/bile acid and xenobiotic metabolism among the top deregulated pathways...
November 14, 2016: Cancer Cell
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