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https://www.readbyqxmd.com/read/28327896/a-randomised-phase-iii-study-of-72%C3%A2-hour-infusional-versus-bolus-bleomycin-in-bep-bleomycin-etoposide-and-cisplatin-chemotherapy-to-treat-igcccg-good-prognosis-metastatic-germ-cell-tumours-te-3
#1
J Shamash, S-J Sarker, R Huddart, S Harland, J K Joffe, D Mazhar, A Birtle, J White, K Chowdhury, P Wilson, M R Marshall, S Vinnicombe
Background: Bleomycin is an integral part of combination chemotherapy in germ cell tumours. Pulmonary toxicity often necessitates drug cessation and death occurs in 1-2% of patients. A continuous infusion of bleomycin might reduce lung toxicity when compared to the conventional weekly boluses given as part of standard BEP chemotherapy. Patients and Methods: A phase 3 trial was conducted based on 212 men with IGCCCG good prognosis metastatic germ cell tumours with 1:1 randomisation...
February 21, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28322063/discrepancies-between-blood-glucose-and-interstitial-glucose-technological-artifacts-or-physiology
#2
Thorsten Siegmund, Lutz Heinemann, Ralf Kolassa, Andreas Thomas
BACKGROUND: For decades, the major source of information used to make therapeutic decisions by patients with diabetes has been glucose measurements using capillary blood samples. Knowledge gained from clinical studies, for example, on the impact of metabolic control on diabetes-related complications, is based on such measurements. Different to traditional blood glucose measurement systems, systems for continuous glucose monitoring (CGM) measure glucose in interstitial fluid (ISF). The assumption is that glucose levels in blood and ISF are practically the same and that the information provided can be used interchangeably...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28321862/identification-obstacle-to-individuation-or-on-how-to-become-me
#3
Alessandra Cavalli
This paper will explore the use of identification with aspects of a lost object as a defensive strategy to cope with traumatic loss, and will show how in the depth of the analytic work this identification can be accessed and made conscious. Descriptions of work with a three-year-old boy illustrate how the sudden loss of his mother's breasts had made weaning un-accessible to him, and how, in the absence of a good experience of separation, the process of mourning had not been able to take place. Instead, identification with aspects of the lost breast was used as a defence against pain, and this state of affairs was proving a hindrance to individuation...
April 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28321579/performance-of-three-generations-of-xpert-mrsa-in-routine-practice-approaching-the-aim
#4
H Jacqmin, A Schuermans, S Desmet, J Verhaegen, V Saegeman
The aim of this study was to evaluate retrospectively the performance of the Xpert MRSA assay in routine practice and its current use in the intensive care unit (ICU) setting of our hospital, since a pre-emptive isolation strategy has been applied. A total of 6473 patients were routinely screened with ESwab for methicillin-resistant Staphylococcus aureus (MRSA) using three generations of rapid real-time polymerase chain reaction (PCR) (Cepheid GeneXpert) over three consecutive periods of time. Performance was evaluated using broth enrichment culture as the reference method...
March 20, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28321232/chronological-sequence-of-leaf-phenology-xylem-and-phloem-formation-and-sap-flow-of-quercus-pubescens-from-abandoned-karst-grasslands
#5
Martina Lavrič, Klemen Eler, Mitja Ferlan, Dominik Vodnik, Jožica Gričar
Intra-annual variations in leaf development, radial growth, including the phloem part, and sap flow have rarely been studied in deciduous trees from drought-prone environments. In order to understand better the chronological order and temporal course of these processes, we monitored leaf phenology, xylem and phloem formation and sap flow in Quercus pubescens from abandoned karst grasslands in Slovenia during the growing season of 2014. We found that the initial earlywood vessel formation started before bud opening at the beginning of April...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28320884/replication-restart-in-bacteria
#6
Bénédicte Michel, Steven J Sandler
In bacteria replication forks assembled at a replication origin travel to the terminus, often a few megabases away. They may encounter obstacles that trigger replisome disassembly, rendering replication restart from abandoned forks crucial for cell viability. During the past 25 years the genes that encode replication restart proteins have been identified and genetically characterized. In parallel, the enzymes were purified and analyzed in vitro, where they can catalyze replication initiation in a sequence-independent manner from fork-like DNA structures...
March 20, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28319699/urdaibai-biosphere-reserve-biscay-spain-conservation-against-development
#7
Nekane Castillo-Eguskitza, Alejandro J Rescia, Miren Onaindia
The protected area approach has extended from conserving biodiversity to improving human well-being. However, the relationship between conservation and socioeconomic and cultural development continues to be controversial. This paper combines land use variables with socioeconomic and cultural variables through multivariate ordination analysis and evaluates their evolution in two areas inside and outside a Biosphere Reserve since the approval of the Governance Plan for Use and Management in the Reserve. The results indicate a similar tendency in the two areas, from the abandonment of traditional rural activities and decline in pine plantations to naturalness, urban sprawl and the growth of the tertiary economic sector, welfare indicators and sustainability index...
March 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28318819/slow-pathway-radiofrequency-ablation-using-magnetic-navigation-a-description-of-technique-and-retrospective-case-analysis
#8
Abhishek Bhaskaran, Maha Albarri, Neil Ross, Sara Al Raisi, Rahul Samantha, Leonette Roode, Fazlur Nadri, Jeanette Ng, Stuart Thomas, Aravinda Thiagalingam, Pramesh Kovoor
BACKGROUND: The Magnetic Navigation System (MNS) catheter was shown to be stable in the presence of significant cardiac wall motion and delivered more effective lesions compared to manual control. This stability could potentially make AV junctional reentrant tachycardia (AVNRT) ablation safer. The aim of this study is to describe the method of mapping and ablation of AVNRT with MNS and 3-D electro-anatomical mapping system (CARTO, Biosense Webster, Diamond bar, CA, USA) anatomical mapping, with a view to improve the safety of ablation...
February 21, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28306744/ranging-behaviour-and-habitat-preferences-of-the-martial-eagle-implications-for-the-conservation-of-a-declining-apex-predator
#9
Rowen van Eeden, D Philip Whitfield, Andre Botha, Arjun Amar
Understanding the ranging behaviours of species can be helpful in effective conservation planning. However, for many species that are rare, occur at low densities, or occupy challenging environments, this information is often lacking. The Martial Eagle (Polemaetus bellicosus) is a low density apex predator declining in both non-protected and protected areas in southern Africa, and little is known about its ranging behaviour. We use GPS tags fitted to Martial Eagles (n = 8) in Kruger National Park (KNP), South Africa to describe their ranging behaviour and habitat preference...
2017: PloS One
https://www.readbyqxmd.com/read/28303928/collection-and-characterization-of-grapevine-genetic-resources-vitis-vinifera-in-the-holy-land-towards-the-renewal-of-ancient-winemaking-practices
#10
Elyashiv Drori, Oshrit Rahimi, Annarita Marrano, Yakov Henig, Hodaya Brauner, Mali Salmon-Divon, Yishay Netzer, Maria Lucia Prazzoli, Maria Stanevsky, Osvaldo Failla, Ehud Weiss, Maria Stella Grando
The importance and extent of wine consumption in all life aspects at the Holy Land is well documented. The Muslim influence in this region led to the abandonment of winemaking practices, and possible loss of indigenous wine varieties. Here we present a country wide collection of the local grapevine population including wild and cultivated forms, and its characterization by genetic, ampelographic and enological methods. The ampelographic analysis shows clear differences between Sativa and Sylvestris groups in flower, leaf and cluster parameters, and that most Sativa belong to proles orientalis...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302868/oxidative-ecology-of-paternal-care-in-wild-smallmouth-bass-micropterus-dolomieu
#11
Laura K Elmer, Constance M O'Connor, David P Philipp, Glen Van Der Kraak, Kathleen M Gilmour, William G Willmore, Brandon L Barthel, Steven J Cooke
Physiologically, oxidative stress is considered a homeostatic imbalance between reactive oxygen species production and absorption. From an ecological perspective, oxidative stress may serve as an important constraint to life history traits such as lifespan, reproduction, and the immune system, and is gaining interest as a potential mechanism underlying life history trade-offs. Of late, there has been much interest in understanding the role of oxidative stress in the ecology of wild animals, particularly during challenging periods such as reproduction...
March 16, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28302209/-a-comparative-analysis-of-neonatal-critical-illness-score-and-score-for-neonatal-acute-physiology-perinatal-extension-version-ii
#12
Cui-Yao Chen, Wei-Min Huang, Xin-Hua Qian, Li-Jun Tang
OBJECTIVE: To investigate the accuracy and clinical utility of neonatal critical illness score (NCIS) and score for neonatal acute physiology, perinatal extension, version II (SNAPPE-II) in predicting the "dead and abandoned" risk in critically ill neonates. METHODS: A total of 269 critically ill neonates were divided into two groups according to their prognosis: dead/abandoned and improved/cured. The accuracy of these two scoring systems, NCIS and SNAPPE-II, in predicting the "dead and abandoned" risk was compared...
March 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28299747/the-measurement-of-water-scarcity-defining-a-meaningful-indicator
#13
REVIEW
Simon Damkjaer, Richard Taylor
Metrics of water scarcity and stress have evolved over the last three decades from simple threshold indicators to holistic measures characterising human environments and freshwater sustainability. Metrics commonly estimate renewable freshwater resources using mean annual river runoff, which masks hydrological variability, and quantify subjectively socio-economic conditions characterising adaptive capacity. There is a marked absence of research evaluating whether these metrics of water scarcity are meaningful...
March 15, 2017: Ambio
https://www.readbyqxmd.com/read/28299591/dealing-with-the-other-between-the-ethical-and-the-moral-albinism-on-the-african-continent
#14
Elvis Imafidon
Albinism is a global public health issue but it assumes a peculiar nature in the African continent due, in part, to the social stigma faced by persons with albinism (PWAs) in Africa. I argue that there are two essential reasons for this precarious situation. First, in the African consciousness, albinism is an alterity or otherness. The PWA in Africa is not merely a physical other but also an ontological other in the African community of beings, which provides a hermeneutic for the stigmatising separateness or difference of the PWA...
March 15, 2017: Theoretical Medicine and Bioethics
https://www.readbyqxmd.com/read/28299257/cleft-lip-and-palate-parental-experiences-of-stigma-discrimination-and-social-structural-inequalities
#15
Wasiu Lanre Adeyemo, Olutayo James, Azeez Butali
BACKGROUND: Cleft lip and palate (CLP) are the most common craniofacial birth impairment and one of the most common congenital impairments in humans. Anecdotal evidence suggests that stigmatization, discrimination, and sociocultural inequalities are common "phenomenon" experienced by families of children with CLP in Nigeria. This study aimed to explore the stigmatization, discrimination, and sociocultural inequalities experiences of families with children born with CLP. MATERIALS AND METHODS: The study was carried out at the surgical outpatient cleft clinic of the Lagos University Teaching Hospital, Lagos, Nigeria...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28298020/the-first-formulation-of-image-based-stereotactic-principles-the-forgotten-work-of-gaston-contremoulins
#16
Cole A Giller, Patrick Mornet, Jean-François Moreau
Although image-based human stereotaxis began with Spiegel and Wycis in 1947, the major principles of radiographic stereotaxis were formulated 50 years earlier by the French scientific photographer Gaston Contremoulins. In 1897, frustrated by the high morbidity of bullet extraction from the brain, the Parisian surgeon Charles Rémy asked Contremoulins to devise a method for bullet localization using the then new technology of x-rays. In doing so, Contremoulins conceived of many of the modern principles of stereotaxis, including the use of a reference frame, radiopaque fiducials for registration, images to locate the target in relation to the frame, phantom devices to locate the target in relation to the fiducial marks, and the use of an adjustable pointer to guide the surgical approach...
February 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28297069/is-early-cannulation-of-an-arteriovenous-fistula-associated-with-early-failure-of-the-fistula
#17
Teun Wilmink, Lee Hollingworth, Tamasin Stevenson, Sarah Powers
OBJECTIVE: To study the effect of early cannulation of arteriovenous fistulas (AVF) on early AVF failure. METHODS: Analysis of two databases of access operations and dialysis sessions from 1/12/2002 till 1/4/2015. Follow-up until 1/4/2016. Functional dialysis use defined as six consecutive cannulations of the AVF with two needles. Early cannulation defined as needling of the AVF within 30 days of creation. Early failure was defined as abandonment for new form of access within 90 days of first cannulation...
March 6, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28292644/resilient-landscapes-in-mediterranean-urban-areas-understanding-factors-influencing-forest-trends
#18
Antonio Tomao, Valerio Quatrini, Piermaria Corona, Agostino Ferrara, Raffaele Lafortezza, Luca Salvati
Urban and peri-urban forests are recognized as basic elements for Nature-Based Solutions (NBS), as they preserve and may increase environmental quality in urbanized contexts. For this reason, the amount of forest land per inhabitant is a pivotal efficiency indicator to be considered in the sustainable governance, land management, planning and design of metropolitan areas. The present study illustrates a multivariate analysis of per-capita forest area (PFA) in mainland Attica, the urban region surrounding Athens, Greece...
March 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/28292228/revisiting-health-regionalization-in-canada
#19
Paul Barker, John Church
Twenty years ago, many of Canada's provinces began to introduce regional health authorities to address problems with their health care systems. With this action, the provinces sought to achieve advances in community decision-making, the integration of health services, and the provision of care in the home and community. The authorities were also to help restrict health care costs. An assessment of the authorities indicates, however, that over the past two decades they have been unable to meet their objectives...
April 2017: International Journal of Health Services: Planning, Administration, Evaluation
https://www.readbyqxmd.com/read/28291693/synthesis-and-evaluation-of-a-ligand-targeting-the-%C3%AE-and-%C3%AE-opioid-receptors-for-drug-delivery-to-lung-cancer
#20
Guo Li, Philip S Low
A well-established approach to developing new imaging agents and treatments for cancer begins with the recognition of receptors that are overexpressed in cancer cells. Ideally, these same receptors would also be absent, or minimally expressed, in healthy tissue. The mu (μ) and delta (δ) opioid receptors (MOR and DOR respectively) match these criteria, with expression in cancer cells that is higher than primary lung epithelial cells. Naltrexone is a drug approved by the U.S. Food and Drug Administration (FDA) for treatment of alcohol dependence or prevention of relapse from opioid addiction...
June 28, 2016: Bioorganic & Medicinal Chemistry Letters
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