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https://www.readbyqxmd.com/read/9257197/vitamin-d3-analogs-and-their-24-oxo-metabolites-equally-inhibit-clonal-proliferation-of-a-variety-of-cancer-cells-but-have-differing-molecular-effects
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COMPARATIVE STUDY
M J Campbell, G S Reddy, H P Koeffler
The seco-steroid hormone, 1 alpha, 25 dihydroxyvitamin D3 (1 alpha,25(OH)2D3) binds to a specific nuclear receptor that acts as a ligand-inducible transcription factor. The resulting genomic effects include partial arrest in G0/G1 of the cell cycle and induction of differentiation; these effects have been observed in various types of cancer. Recently, we produced enzymatically the natural 24-oxo metabolites of 1 alpha,25(OH)2D3 and two of its potent synthetic analogs (1 alpha,25-(OH)2-16-ene-D3 and 1 alpha,25-(OH)2-20-epi-D3) using a rat kidney perfusion system...
September 1, 1997: Journal of Cellular Biochemistry
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