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traumatic brain injury guidelines

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https://www.readbyqxmd.com/read/28991814/management-of-traumatic-brain-injury-in-the-emergency-department-guideline-adherence-and-patient-safety
#1
Tomas Vedin, Marcus Edelhamre, Mathias Karlsson, Michael Bergenheim, Per-Anders Larsson
BACKGROUND: Traumatic brain injury is a common reason not only for emergency visits worldwide but also for significant morbidity and mortality. Several clinical guidelines exist but adherence is generally low. AIM: To study attitudes toward computed tomography of the head among emergency department Change to physicians throughout the article who manage patients with trauma to the head and doctors' adherence to guidelines. METHODS: Quantitative questionnaire study with questionnaires collected over 3 months before introduction of new guidelines...
October 2017: Quality Management in Health Care
https://www.readbyqxmd.com/read/28985560/ferroptosis-a-regulated-cell-death-nexus-linking-metabolism-redox-biology-and-disease
#2
REVIEW
Brent R Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I Bush, Marcus Conrad, Scott J Dixon, Simone Fulda, Sergio Gascón, Stavroula K Hatzios, Valerian E Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C Pagnussat, Jason Park, Qitao Ran, Craig S Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M Torti, Suzy V Torti, Shinya Toyokuni, K A Woerpel, Donna D Zhang
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have developed complex systems that exploit and defend against this vulnerability in different contexts. The sensitivity to ferroptosis is tightly linked to numerous biological processes, including amino acid, iron, and polyunsaturated fatty acid metabolism, and the biosynthesis of glutathione, phospholipids, NADPH, and coenzyme Q10...
October 5, 2017: Cell
https://www.readbyqxmd.com/read/28981348/traumatic-brain-injury-clinical-practice-guidelines-and-best-practices-from-the-va-state-of-the-art-conference
#3
Joel Scholten, Jennifer J Vasterling, Jamie B Grimes
Management of symptoms following traumatic brain injury (TBI) can be complex and remains a high priority for Department of Defense (DoD) and Department of Veteran Affairs (VA). Concurrently, awareness of TBI in the public has increased. VA convened a State of the Art (SOTA) Conference to identify priorities for future research and promote best practices for TBI care. Scientific evidence of effective management of symptoms following TBI is expanding, and this evidence has been synthesized into Clinical Practice Guidelines (CPGs) and Clinical Practice Recommendations (CPRs)...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28947465/cobi-continuous-hyperosmolar-therapy-for-traumatic-brain-injured-patients-trial-protocol-a-multicentre-randomised-open-label-trial-with-blinded-adjudication-of-primary-outcome
#4
Antoine Roquilly, Sigismond Lasocki, Jean Denis Moyer, Olivier Huet, Pierre François Perrigault, Claire Dahyot-Fizelier, Philippe Seguin, Tarek Sharshar, Thomas Geeraerts, Francis Remerand, Fanny Feuillet, Karim Asehnoune
INTRODUCTION: Traumatic brain injury (TBI) is a major cause of death and severe prolonged disability. Intracranial hypertension (ICH) is a critical risk factor of bad outcomes after TBI. Continuous infusion of hyperosmolar therapy has been proposed for the prevention and the treatment of ICH. Whether an early administration of continuous hyperosmolar therapy improves long-term outcomes of patients with TBI is uncertain. The aim of the COBI study (number clinicaltrial.gov 03143751, pre-results stage) is to assess the efficiency and the safety of continuous hyperosmolar therapy in patients with TBI...
September 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28939250/not-every-trauma-patient-with-a-radiographic-head-injury-requires-transfer-for-neurosurgical-evaluation-application-of-the-brain-injury-guidelines-to-patients-transferred-to-a-level-1-trauma-center
#5
Gweniviere Kayla Capron, Mary Beth Voights, Henry R Moore, Derek B Wall
BACKGROUND: Patients with radiographically-identified traumatic brain injury are often transferred to our regional trauma center for neurosurgical evaluation, yet few injuries require neurosurgical intervention. Transfer is costly, inconvenient, and potentially risky in inclement weather. We propose that previously-published brain injury guidelines (BIG)(1) can help to determine which patients could avoid mandatory transfer. METHODS: Retrospective chart review of patients transferred between January 2012 and December 2013 was performed...
September 18, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28938277/multimodality-neuromonitoring-in-adult-traumatic-brain-injury-a-narrative-review
#6
Martin Smith
Neuromonitoring plays an important role in the management of traumatic brain injury. Simultaneous assessment of cerebral hemodynamics, oxygenation, and metabolism allows an individualized approach to patient management in which therapeutic interventions intended to prevent or minimize secondary brain injury are guided by monitored changes in physiologic variables rather than generic thresholds. This narrative review describes various neuromonitoring techniques that can be used to guide the management of patients with traumatic brain injury and examines the latest evidence and expert consensus guidelines for neuromonitoring...
September 22, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28934444/letter-guidelines-for-the-management-of-severe-traumatic-brain-injury-fourth-edition
#7
Rob Dickerman, Ashley Reynolds, Julie Williamson, Karl Winters
No abstract text is available yet for this article.
October 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28933211/traumatic-brain-injury-current-treatment-strategies-and-future-endeavors
#8
Michael Galgano, Gentian Toshkezi, Xuecheng Qiu, Thomas Russell, Lawrence Chin, Li-Ru Zhao
Traumatic brain injury (TBI) presents in various forms ranging from mild alterations of consciousness to an unrelenting comatose state and death. In the most severe form of TBI, the entirety of the brain is affected by a diffuse type of injury and swelling. Treatment modalities vary extensively based on the severity of the injury and range from daily cognitive therapy sessions to radical surgery such as bilateral decompressive craniectomies. Guidelines have been set forth regarding the optimal management of TBI, but they must be taken in context of the situation and cannot be used in every individual circumstance...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28928193/the-course-and-prognostic-factors-of-cognitive-status-after-central-nervous-system-trauma-a-systematic-review-protocol
#9
Tatyana Mollayeva, Nicole Pacheco, Andrea D'Souza, Angela Colantonio
INTRODUCTION: Traumatic brain injury (TBI) is among the most disabling injuries, resulting in a range of cognitive impairments. Traumatic spinal cord injury (SCI) often occurs in conjunction with TBI; the two are best considered together in the context of trauma to the central nervous system (CNS). Despite strong indications of cognitive dysfunction in CNS trauma, little is known about its natural history or relationship with other factors. The current protocol outlines a strategy for a systematic review of the current evidence examining CNS trauma as a prognostic factor of cognitive decline in the adult population...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28926566/guidelines-for-the-management-of-a-brain-death-donor-in-the-rhesus-macaque-a-translational-transplant-model
#10
Tiffany J Zens, Juan S Danobeitia, Peter J Chlebeck, Laura J Zitur, Scott Odorico, Kevin Brunner, Jennifer Coonen, Saverio Capuano, Anthony M D'Alessandro, Kristina Matkowskyj, Weixiong Zhong, Jose Torrealba, Luis Fernandez
INTRODUCTION: The development of a translatable brain death animal model has significant potential to advance not only transplant research, but also the understanding of the pathophysiologic changes that occur in brain death and severe traumatic brain injury. The aim of this paper is to describe a rhesus macaque model of brain death designed to simulate the average time and medical management described in the human literature. METHODS: Following approval by the Institutional Animal Care and Use Committee, a brain death model was developed...
2017: PloS One
https://www.readbyqxmd.com/read/28918666/treatment-options-for-severe-traumatic-brain-injuries-in-children-current-therapies-challenges-and-future-prospects
#11
Lisa A DelSignore, Robert C Tasker
Severe traumatic brain injury (TBI) afflicts many children and adults worldwide, resulting in high rates of morbidity and mortality. Recent therapeutic advances have focused on both surgical and medical treatment options, but none have been proven to reduce overall morbidity and mortality in this population. Areas covered: Several emerging therapies are addressed that focus on treating related secondary injuries and other clinical sequelae post-TBI during the acute injury phase (defined by authors as up to four weeks post-injury)...
September 22, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28905727/-teach-to-goal-to-better-assess-informed-consent-comprehension-among-incarcerated-clinical-research-participants
#12
Cyrus Ahalt, Rebecca Sudore, Marielle Bolano, Lia Metzger, Anna M Darby, Brie Williams
Correctional health research requires important safeguards to ensure that research participation is ethically conducted. In addition to having disproportionately low educational attainment and low literacy, incarcerated people suffer from health-related conditions that can affect cognition (e.g., traumatic brain injury, substance use disorders, mental illness). Yet modified informed consent processes that assess participants' comprehension of the risks and benefits of participation are not required by relevant federal guidelines...
September 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28895488/a-systematic-review-of-psychological-interventions-for-sleep-and-fatigue-after-mild-traumatic-brain-injury
#13
Karen Sullivan, Hannah Blaine, Sherrie-Anne Kaye, Alice Theadom, Catherine Haden, Simon Smith
This review evaluated the evidence for psychological interventions to improve sleep and reduce fatigue after mild traumatic brain injury (TBI). Eight electronic databases were searched up until August 2016 for studies that: (1) included adults; (2) tested intervention effectiveness on sleep quality and fatigue, post-acutely; (3) applied a broadly-defined psychological intervention (e.g., cognitive behavioural therapy [CBT], counselling, or education). Only randomized controlled trials were eligible for inclusion...
September 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28874206/variation-in-monitoring-and-treatment-policies-for-intracranial-hypertension-in-traumatic-brain-injury-a-survey-in-66-neurotrauma-centers-participating-in-the-center-tbi-study
#14
Maryse C Cnossen, Jilske A Huijben, Mathieu van der Jagt, Victor Volovici, Thomas van Essen, Suzanne Polinder, David Nelson, Ari Ercole, Nino Stocchetti, Giuseppe Citerio, Wilco C Peul, Andrew I R Maas, David Menon, Ewout W Steyerberg, Hester F Lingsma
BACKGROUND: No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that centers and practitioners individually balance potential benefits and risks of different intracranial pressure (ICP) management strategies, resulting in practice variation. The aim of this study was to examine variation in monitoring and treatment policies for intracranial hypertension in patients with TBI. METHODS: A 29-item survey on ICP monitoring and treatment was developed on the basis of literature and expert opinion, and it was pilot-tested in 16 centers...
September 6, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28872457/feature-clustering-of-intracranial-pressure-time-series-for-an-alarm-function-estimation-in-traumatic-brain-injury
#15
Michal Teplan, Ivan Bajla, Roman Rosipal, Martin Rusnák
The guidelines for the management of Traumatic Brain Injury (TBI) recommend that IntraCranial Presure (ICP) should be monitored in all salvageable patients with severe TBI, albeit this quantity cannot identify the specific mechanisms of pressure elevation. The conventional application of ICP monitoring consists merely in acquisition of ICP values in discrete time and their comparison to the established ICP threshold. The excess of this threshold triggers the special emergency treatment protocol...
September 5, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28860331/the-screening-and-management-of-pituitary-dysfunction-following-traumatic-brain-injury-in-adults-british-neurotrauma-group-guidance
#16
REVIEW
Chin Lik Tan, Seyed Alireza Alavi, Stephanie E Baldeweg, Antonio Belli, Alan Carson, Claire Feeney, Anthony P Goldstone, Richard Greenwood, David K Menon, Helen L Simpson, Andrew A Toogood, Mark Gurnell, Peter J Hutchinson
Pituitary dysfunction is a recognised, but potentially underdiagnosed complication of traumatic brain injury (TBI). Post-traumatic hypopituitarism (PTHP) can have major consequences for patients physically, psychologically, emotionally and socially, leading to reduced quality of life, depression and poor rehabilitation outcome. However, studies on the incidence of PTHP have yielded highly variable findings. The risk factors and pathophysiology of this condition are also not yet fully understood. There is currently no national consensus for the screening and detection of PTHP in patients with TBI, with practice likely varying significantly between centres...
November 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28841573/pediatric-providers-attitudes-and-practices-regarding-concussion-diagnosis-and-management
#17
Khalida Itriyeva, Ronald Feinstein, Linda Carmine
Background Concussions, a form of mild traumatic brain injury, are a current "hot topic" in sports and medicine, with current research focusing on diagnosis, treatment, and the long-term effects of repeated concussions on development of chronic traumatic encephalopathy. Concussions represent 8.9% of all high school athletic injuries, and pediatricians see many of these patients in their practices, however evolving guidelines and recommendations have resulted in varying practices among providers. Objective To assess how local pediatricians in New York Chapter 2 of the American Academy of Pediatrics (AAP) diagnose and treat concussion patients, and to evaluate the need for continuing education in this area...
August 25, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28832674/the-aggressiveness-of-neurotrauma-practitioners-and-the-influence-of-the-impact-prognostic-calculator
#18
Joshua Letsinger, Casey Rommel, Ryan Hirschi, Raminder Nirula, Gregory W J Hawryluk
Published guidelines have helped to standardize the care of patients with traumatic brain injury; however, there remains substantial variation in the decision to pursue or withhold aggressive care. The International Mission for Prognosis and Analysis of Clinical Trials in TBI (IMPACT) prognostic calculator offers the opportunity to study and decrease variability in physician aggressiveness. The authors wish to understand how IMPACT's prognostic calculations currently influence patient care and to better understand physician aggressiveness...
2017: PloS One
https://www.readbyqxmd.com/read/28826717/head-computed-tomography-scan-in-isolated-traumatic-brain-injury-in-a-low-income-country
#19
Armel Flavien Kabore, Aziz Ouedraogo, Kélan Bertille Ki, Salah Seif Idriss Traore, Ibrahim Alain Traore, Cheik Tidiane Hafiz Bougouma, Darko Arnaudovski, Ousseini Diallo, Sylvain Zabsonre, Nazinigouba Ouedraogo, Pascal Augustin
BACKGROUND: Head Computed Tomography Scan (HCTS) is the cornerstone of the management of traumatic brain injury (TBI). The impact of performing HCTS in TBI has been scarcely investigated in low income countries (LICs). Furthermore, the cost of a HCTS is a burden for family finances. METHODS: A prospective observational study was conducted in Burkina Faso. All consecutive patients with isolated TBI needing a HCTS were included. Result and impact of HCTS were evaluated...
August 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28811137/influence-of-guidelines-on-management-of-paediatric-mild-traumatic-brain-injury-ct-assessment-and-admission-policy
#20
J J Lenstra, A R A Pikstra, J M Fock, Z Metting, J van der Naalt
BACKGROUND: The annual number of paediatric injury-related emergency visits and application of computed tomography (CT) has substantially increased, with associated higher risk of malignancies. In 2010, a guideline for CT-assessment based on risk factors for patients with mild traumatic brain injury (mTBI) became effective in all Emergency Departments (ED) in the Netherlands. This study evaluated the influence of this guideline on the frequency of CT-assessments, hospital admissions and factors that are related to guideline adherence...
August 3, 2017: European Journal of Paediatric Neurology: EJPN
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