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https://www.readbyqxmd.com/read/29781355/development-and-biological-validation-of-a-cyclic-stretch-culture-system-for-the-ex-vivo-engineering-of-tendons
#1
Manuela Teresa Raimondi, Matteo Laganà, Claudio Conci, Michele Crestani, Alessia Di Giancamillo, Francesca Gervaso, Daniela Deponti, Federica Boschetti, Michele M Nava, Chiara Scandone, Cinzia Domeneghini, Alessandro Sannino, Giuseppe M Peretti
INTRODUCTION: An innovative approach to the treatment of tendon injury or degeneration is given by engineered grafts, made available through the development of bioreactors that generate tendon tissue in vitro, by replicating in vivo conditions. This work aims at the design of a bioreactor capable of applying a stimulation of cyclic strain on cell constructs to promote the production of bioartificial tissue with mechanical and biochemical properties resembling those of the native tissue...
May 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29772828/wetting-behaviors-of-a-nano-droplet-on-a-rough-solid-substrate-under-perpendicular-electric-field
#2
Fenhong Song, Long Ma, Jing Fan, Qicheng Chen, Lihui Zhang, Ben Q Li
Molecular dynamic simulations were adopted to study the wetting properties of nanoscale droplets on rough silicon solid substrate subject to perpendicular electric fields. The effect of roughness factor and electric field strength on the static and dynamic wetting behaviors of a nano-droplet on a solid surface was investigated at the molecular level. Results show that the static contact angle tends to decrease slightly and show small difference with the increase of roughness factor, while it shows an obvious increase for the ramp-shaped surface because the appearing bottom space reduces the wettability of solid surface...
May 17, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29763517/novel-engineered-tendon-fibrocartilage-bone-composite-with-cyclic-tension-for-rotator-cuff-repair
#3
Qian Liu, Taku Hatta, Jun Qi, Haoyu Liu, Andrew R Thoreson, Peter C Amadio, Steven L Moran, Scott P Steinmann, Anne Gingery, Chunfeng Zhao
Surgical repair of rotator cuff tears presents a significant clinical challenge with high failure rates and inferior functional outcomes. Graft augmentation improves repair outcomes, however currently available grafting materials have limitations. While cell-seeded decellularized tendon slices may facilitate cell infiltration, promote tendon incorporation and preserve original mechanical strength, the unique fibrocartilage zone is yet to be successfully reestablished. In this study, we investigated the biological and mechanical properties of an engineered tendon-fibrocartilage-bone composite (TFBC) with cyclic tension (3% strain, 0...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29740567/effects-of-ankle-strengthening-exercise-program-on-an-unstable-supporting-surface-on-proprioception-and-balance-in-adults-with-functional-ankle-instability
#4
Sun-Young Ha, Jun-Ho Han, Yun-Hee Sung
The present study was conducted to investigate the effect of ankle strengthening exercise applied on unstable supporting surfaces on the proprioceptive sense and balance in adults with functional ankle instability. As for the study method, 30 adults with functional ankle instability were randomly assigned to an ankle strengthening exercise group and a stretching group on unstable supporting surfaces, and the interventions were implemented for 40 min. Before and after the interventions, a digital dual inclinometer was used to measure the proprioceptive sense of the ankle, the Balancia program was used to measure static balance ability, and the functional reach test was used to measure dynamic balance ability...
April 2018: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29721606/the-effects-of-different-durations-of-static-stretching-within-a-comprehensive-warm-up-on-voluntary-and-evoked-contractile-properties
#5
Jonathan C Reid, Rebecca Greene, James D Young, Daniel D Hodgson, Anthony J Blazevich, David G Behm
Evidence for performance decrements following prolonged static stretching (SS) has led to a paradigm shift in stretching routines within a warm-up. Rather than SS, dynamic stretching (DS) and dynamic activity (DA) have replaced SS within warm-up routines. The objective of the present study was to compare the effect of differing lower limb SS durations (30 [SS30s], 60 [SS60s] or 120 s [SS120s] of SS per muscle group or no-stretch control) within a comprehensive warm-up protocol consisting of aerobic activity, DS and DA...
May 2, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29715593/microdevice-arrays-with-strain-sensors-for-3d-mechanical-stimulation-and-monitoring-of-engineered-tissues
#6
Haijiao Liu, Luke A MacQueen, Jenna F Usprech, Hoda Maleki, Krista L Sider, Matthew G Doyle, Yu Sun, Craig A Simmons
Native and engineered tissue development are regulated by the integrative effects of multiple microenvironmental stimuli. Microfabricated bioreactor array platforms can efficiently dissect cue-response networks, and have recently integrated critical 2D and 3D mechanical stimulation for greater physiological relevance. However, a limitation of these approaches is that assessment of tissue functional properties is typically limited to end-point analyses. Here we report a new deformable membrane platform with integrated strain sensors that enables mechanical stretching or compression of 3D cell-hydrogel arrays and simultaneous measurement of hydrogel construct stiffness in situ...
April 23, 2018: Biomaterials
https://www.readbyqxmd.com/read/29697023/comparison-of-vibration-rolling-nonvibration-rolling-and-static-stretching-as-a-warm-up-exercise-on-flexibility-joint-proprioception-muscle-strength-and-balance-in-young-adults
#7
Chia-Lun Lee, I-Hua Chu, Bo-Jhang Lyu, Wen-Dien Chang, Nai-Jen Chang
Warm-up is an essential component for optimizing performance before an exercise session. This study investigated that the immediate effects of vibration rolling (VR), nonvibration rolling (NVR), and static stretching as a part of a warm-up regimen on the flexibility, knee joint proprioception, muscle strength, and dynamic balance of the lower extremity in young adults. Compared with the preintervention, VR induced the range of motion of knee flexion and extension significantly increased by 2.5% and 6%, respectively, and isokinetic peak torque and dynamic balance for muscle strength and dynamic balance increased by 33%-35% and 1...
April 26, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29674971/a-numerical-study-of-scalable-cardiac-electro-mechanical-solvers-on-hpc-architectures
#8
Piero Colli Franzone, Luca F Pavarino, Simone Scacchi
We introduce and study some scalable domain decomposition preconditioners for cardiac electro-mechanical 3D simulations on parallel HPC (High Performance Computing) architectures. The electro-mechanical model of the cardiac tissue is composed of four coupled sub-models: (1) the static finite elasticity equations for the transversely isotropic deformation of the cardiac tissue; (2) the active tension model describing the dynamics of the intracellular calcium, cross-bridge binding and myofilament tension; (3) the anisotropic Bidomain model describing the evolution of the intra- and extra-cellular potentials in the deforming cardiac tissue; and (4) the ionic membrane model describing the dynamics of ionic currents, gating variables, ionic concentrations and stretch-activated channels...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29672055/ultrafast-dynamics-of-the-mlct-excited-states-of-ir-iii-proteo-and-deutero-dihydrides
#9
Chelsea Marie Taliaferro, Evgeny O Danilov, Felix N Castellano
For decades, transition metal hydrides have been at the forefront of numerous photocatalytic reactions leveraging either photoacid or photohydride generation. Of upmost importance is the nature of the M-H bond itself, which is typically the major site of photochemical reactivity, particularly in Ir(III) hydrides featuring metal-to-ligand charge transfer (MLCT) excited states. As a departure point for understanding the fundamental spectroscopy and photophysics of the MLCT excited states of Ir(III) diimine hydrides, cis-[Ir(bpy)2H2]+ (bpy = 2,2'-bipyridine) and its deuterated analog cis-[Ir(bpy)2D2]+ were prepared and investigated...
April 19, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29670537/impact-of-different-tidal-volume-levels-at-low-mechanical-power-on-ventilator-induced-lung-injury-in-rats
#10
Lillian Moraes, Pedro L Silva, Alessandra Thompson, Cintia L Santos, Raquel S Santos, Marcos V S Fernandes, Marcelo M Morales, Vanessa Martins, Vera L Capelozzi, Marcelo G de Abreu, Paolo Pelosi, Patricia R M Rocco
Tidal volume (VT ) has been considered the main determinant of ventilator-induced lung injury (VILI). Recently, experimental studies have suggested that mechanical power transferred from the ventilator to the lungs is the promoter of VILI. We hypothesized that, as long as mechanical power is kept below a safe threshold, high VT should not be injurious. The present study aimed to investigate the impact of different VT levels and respiratory rates (RR) on lung function, diffuse alveolar damage (DAD), alveolar ultrastructure, and expression of genes related to inflammation [interleukin (IL)-6], alveolar stretch (amphiregulin), epithelial [club cell secretory protein (CC)16] and endothelial [intercellular adhesion molecule (ICAM)-1] cell injury, and extracellular matrix damage [syndecan-1, decorin, and metalloproteinase (MMP)-9] in experimental acute respiratory distress syndrome (ARDS) under low-power mechanical ventilation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29662346/dc-dynamic-pull-in-instability-of-a-dielectric-elastomer-balloon-an-energy-based-approach
#11
Atul Kumar Sharma, Nitesh Arora, M M Joglekar
This paper reports an energy-based method for the dynamic pull-in instability analysis of a spherical dielectric elastomer (DE) balloon subjected to a quasi-statically applied inflation pressure and a Heaviside step voltage across the balloon wall. The proposed technique relies on establishing the energy balance at the point of maximum stretch in an oscillation cycle, followed by the imposition of an instability condition for extracting the threshold parameters. The material models of the Ogden family are employed for describing the hyperelasticity of the balloon...
March 2018: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29652099/a-novel-dynamic-opto-thermo-mechanical-stress-testing-device-1-design-of-the-device
#12
T Z N Sokkar, K A El-Farahaty, M A El-Bakary, M I Raslan, F E Hanash
This article presents a dynamic opto-thermo-mechanical stress testing device to characterize fiber properties. The device has multi-modes and consists of many functions. These modes include stretching, bending, rotating, twisting, and heating processes. Every process can be controlled by micro-controller unit via software programs specially designed for this purpose. The micro-controller unit can execute two different processes at the same time. Such as, dynamic stretching process under the effect of thermal treatment, dynamic stretching process and relaxation, bending process under the effect of thermal treatment, and so forth...
April 13, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29643516/-preliminary-study-of-robot-assisted-ankle-rehabilitation-for-children-with-cerebral-palsy
#13
R L Wang, Z H Zhou, Y C Xi, Q N Wang, N H Wang, Z Huang
OBJECTIVE: To propose a kind of robotic ankle-foot rehabilitation system for children with cerebral palsy and to preliminarily verify its feasibility in clinical application. METHODS: A robot assisted ankle-foot rehabilitation system was specially designed and developed for children with cerebral palsy and a preliminary clinical study was conducted in Department of Rehabilitation Medicine, Peking University First Hospital. Modified Tardieu Scale and joint biomechanical properties (ankle plantar flexion resistance torque under different ankle dorsiflexion angles) were measured to analyze the muscle tone and soft tissue compliance of the ankle plantar flexors pre- and post-robotic training intervention...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29619447/solvent-dependent-structural-dynamics-of-an-azido-platinum-complex-revealed-by-linear-and-nonlinear-infrared-spectroscopy
#14
Xuemei He, Fengmin Xu, Pengyun Yu, Yanzhou Wu, Fuyi Wang, Yao Zhao, Jianping Wang
The vibrational and anisotropic relaxation dynamics and structural dynamics of a potential anticancer prodrug, trans,trans,trans-[Pt(N3)2(OH)2(py)2], were investigated using time-resolved infrared pump-probe spectroscopy and ultrafast two-dimensional infrared (2D IR) spectroscopy. Herein, two representative bio-friendly solvents, H2O and DMSO, were used, in which the local structural and dynamical variations were monitored using the antisymmetric linear combination of the two N3 stretching vibrational modes as an infrared probe...
April 5, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29603864/vascular-smooth-muscle-cells-direct-extracellular-dysregulation-in-aortic-stiffening-of-hypertensive-rats
#15
Tristan T Hays, Ben Ma, Ning Zhou, Shaunrick Stoll, William J Pearce, Hongyu Qiu
Aortic stiffening is an independent risk factor that underlies cardiovascular morbidity in the elderly. We have previously shown that intrinsic mechanical properties of vascular smooth muscle cells (VSMCs) play a key role in aortic stiffening in both aging and hypertension. Here, we test the hypothesis that VSMCs also contribute to aortic stiffening through their extracellular effects. Aortic stiffening was confirmed in spontaneously hypertensive rats (SHRs) vs. Wistar-Kyoto (WKY) rats in vivo by echocardiography and ex vivo by isometric force measurements in isolated de-endothelized aortic vessel segments...
March 30, 2018: Aging Cell
https://www.readbyqxmd.com/read/29581654/the-effects-of-shoulder-stabilization-exercises-and-pectoralis-minor-stretching-on-balance-and-maximal-shoulder-muscle-strength-of-healthy-young-adults-with-round-shoulder-posture
#16
Mi-Kyoung Kim, Jung Chul Lee, Kyung-Tae Yoo
[Purpose] The purpose of this study was to analyze the effects of pectoralis minor stretching and shoulder strengthening with an elastic band on balance and maximal shoulder muscle strength in young adults with rounded shoulder posture. [Subjects and Methods] Nineteen subjects with rounded shoulder posture were randomly divided into 2 groups: a shoulder stabilization exercise group and a stretching exercise group. The groups performed each exercise for 40 minutes, 3 times a week, for 4 weeks. Static balance (eyes open and closed), dynamic balance (the limits of stability in 4 directions) and shoulder muscle strength in 5 directions were measure before and after the exercises...
March 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29578477/morpho-functional-implications-of-myofascial-stretching-applied-to-muscle-chains-a-case-study
#17
Bogdan Constantin Raţ, Marinela Raţă, Bogdan Antohe
BACKGROUND: Most lesions of the soft tissues, especially those at the muscle level, are due to the lack of elasticity of the connective tissue and fascia. Stretching is one of the most commonly used methods of treatment for such musculoskeletal issues. OBJECTIVE: This study tracks the effects of stretching on the electromyographic activity of muscle chains, applied to a 24-year-old athlete diagnosed with the Haglund's disease. METHOD: For the evaluation, we used visual examination and surface electromyography (maximum volumetric isometric contraction)...
March 16, 2018: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29543123/crossover-effects-of-unilateral-static-stretching-and-foam-rolling-on-contralateral-hamstring-flexibility-and-strength
#18
Benjamin S Killen, Krista L Zelizney, Xin Ye
CONTEXT: Static stretching (SS) and self-administered foam rolling (SAFR) are both effective techniques often used in rehabilitation settings to improve one's range-of-motion (ROM). However, their effects on non-intervened contralateral limb's performance remain equivocal. OBJECTIVE: To examine the acute effects of unilateral hamstrings SS and SAFR on the contralateral hip flexion passive ROM and the strength performance. DESIGN: Randomized crossover trial...
March 15, 2018: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29529387/the-effects-of-different-passive-static-stretching-intensities-on-recovery-from-unaccustomed-eccentric-exercise-a-randomized-controlled-trial
#19
Nikos C Apostolopoulos, Ian M Lahart, Michael J Plyley, Jack Taunton, Alan M Nevill, Yiannis Koutedakis, Matthew Wyon, George S Metsios
Effects of passive static stretching intensity on recovery from unaccustomed eccentric exercise of right knee extensors was investigated in 30 recreationally active males randomly allocated into three groups: high-intensity (70-80% maximum perceived stretch), low-intensity (30-40% maximum perceived stretch), and control. Both stretching groups performed 3 sets of passive static stretching exercises of 60s each for hamstrings, hip flexors, and quadriceps, over 3 consecutive days, post-unaccustomed eccentric exercise...
March 12, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29506306/the-relation-between-stretching-typology-and-stretching-duration-the-effects-on-range-of-motion
#20
REVIEW
Ewan Thomas, Antonino Bianco, Antonio Paoli, Antonio Palma
Different stretching strategies and protocols are widely used to improve flexibility or maintain health, acting on the muscle tendon-unit, in order to improve the range of motion (ROM) of the joints. This review aims to evaluate the current body of literature in order to understand the relation between stretching typology and ROM, and secondly to evaluate if a relation exists between stretching volume (either as a single training session, weekly training and weekly frequency) and ROM, after long-term stretching...
April 2018: International Journal of Sports Medicine
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