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Fumei Duan, Yong Wang, Ying Wang, Han Zhao
The calculation of marginal abatement costs of CO2 plays a vital role in meeting China's 2020 emission reduction targets by providing reference for determining carbon tax and carbon trading pricing. However, most existing researches only used one method to discuss regional and industrial marginal abatement costs, and almost no studies predicted future marginal abatement costs from the perspective of CO2 emission efficiency. To make up for the gaps, this paper first estimates marginal abatement costs of CO2 in three major industries of 30 provinces in China from 2005 to 2015 based on three assumptions...
June 16, 2018: Environmental Science and Pollution Research International
Kirsten A Baken, Rosa M A Sjerps, Merijn Schriks, Annemarie P van Wezel
Toxicological risk assessment of contaminants of emerging concern (CEC) in (sources of) drinking water is required to identify potential health risks and prioritize chemicals for abatement or monitoring. In such assessments, concentrations of chemicals in drinking water or sources are compared to either (i) health-based (statutory) drinking water guideline values, (ii) provisional guideline values based on recent toxicity data in absence of drinking water guidelines, or (iii) generic drinking water target values in absence of toxicity data...
June 13, 2018: Environment International
Mehmet A Oturan, P V Nidheesh, Minghua Zhou
No abstract text is available yet for this article.
June 7, 2018: Chemosphere
Reza Heidari, Akram Jamshidzadeh, Vahid Ghanbarinejad, Mohammad Mehdi Ommati, Hossein Niknahad
Aim of the study: Hepatic encephalopathy and hyperammonemia is a clinical complication associated with liver cirrhosis. The brain is the target organ for ammonia toxicity. Ammonia-induced brain injury is related to oxidative stress, locomotor activity dysfunction, and cognitive deficit, which could lead to permanent brain injury, coma and death if not appropriately managed. There is no promising pharmacological intervention against cirrhosis-associated brain injury. Taurine (TAU) is one of the most abundant amino acids in the human body...
June 2018: Clinical and Experimental Hepatology
Wenzhe Yu, Mengru Tao, Yueliang Zhao, Xiaoqian Hu, Mingfu Wang
Advanced glycation end products (AGEs) could interact with the receptor for AGE (RAGE) as a sterile danger signal to induce inflammation. 4′-methoxyresveratrol (4′MR), a polyphenol derived from Dipterocarpaceae, has not been studied for its anti-inflammation effects. In the present study, we sought to explore the protective role of 4′MR in AGEs-induced inflammatory model using RAW264.7 macrophages. 4′MR significantly inhibited gene expression of pro-inflammatory cytokines and chemokines, such as interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α) and monocyte chemoattractant protein-1 (MCP-1), as well as two typical pro-inflammatory enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2)...
June 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yanjing Wang, Yuanyuan Li
Hepatitis B virus (HBV) is associated with the development of a wide spectrum of liver diseases. The involvement of miRNAs in HBV replication is being gradually identified. Among these miRNAs, miR-146a expression was found to be positively correlated with HBV replication levels. However, the regulatory relationship between miR-146a and HBV replication is still unclear. In the present study, miR-146a was upregulated in HBV-expressing HepG2.2.15 cells compared with HepG2 cells. Overexpression of miR-146a or knockdown of Zinc finger E-box-binding homeobox 2 (ZEB2) promoted HBV replication and expression, while downregulation of miR-146a or overexpression of ZEB2 suppressed HBV replication and expression...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sowjanyaa Jenarthanan, Chandana Subbarao
Introduction: Pain of endodontic origin is of concern to both the patient and the clinician. Expectation of a painful experience can increase the patient's anxiety levels, making treatment more difficult. Management of endodontic pain is one of the challenging aspects in endodontics. Objective: To evaluate whether the intraligamentary mode of administration of diclogfenac sodium is effective in abating endodontic pain during interappointment visits. Aim: The purpose of this clinical trial is to evaluate the analgesic efficacy of diclofenac sodium administered through oral and intraligamentary routes in reducing postendodontic pain...
May 2018: Journal of Conservative Dentistry: JCD
Jian-Ping He, Pei-Pei Hou, Qi-Tao Chen, Wei-Jia Wang, Xiao-Yu Sun, Peng-Bo Yang, Ying-Ping Li, Lu-Ming Yao, Xiaotong Li, Xin-Dong Jiang, Kun-Yi Chien, Zhi-Ming Zhang, Qiu-Wan Wu, Allison J Cowin, Qiao Wu, Hang-Zi Chen
p62 is a receptor that facilitates selective autophagy by interacting simultaneously with cargoes and LC3 protein on the autophagosome to maintain cellular homeostasis. However, the regulatory mechanism(s) behind this process and its association with breast cancer remain to be elucidated. Here we report that Flightless-I (FliI), a novel p62-interacting protein, promotes breast cancer progression by impeding selective autophagy. FliI was highly expressed in clinical breast cancer samples, and heterozygous deletion of FliI retarded development of mammary tumors in PyVT mice...
June 13, 2018: Cancer Research
Raul Morales-Salvador, Ángel Morales-García, Francesc Viñes, Francesc Illas
The performance of novel two-dimensional nitrides in carbon capture and storage (CCS) is analyzed for a broad range of pressures and temperatures. Employing an integrated theoretical framework where CO2 adsorption/desorption rates on the M2N (M = Ti, Zr, Hf, V, Nb, Ta, Cr, Mo, and W) surfaces are derived from transition state theory and density functional theory based calculations, the present theoretical simulations consistently predict that, depending on the particular composition, CO2 can be strongly adsorbed and even activated at temperatures above 1000 K...
June 13, 2018: Physical Chemistry Chemical Physics: PCCP
Yujue Wang, Gang Yu, Shubo Deng, Jun Huang, Bin Wang
The electro-peroxone (E-peroxone) process is an emerging electrochemical advanced oxidation process (EAOP) that combines ozonation with in situ cathodic hydrogen peroxide (H2 O2 ) production to drive the peroxone reaction for water and wastewater treatment. Over the past several years, the E-peroxone process has quickly emerged as a promising EAOP for the abatement of emerging contaminants (ECs) in water. Because of the enhanced ozone (O3 ) transformation to hydroxyl radicals (OH) by electro-generated H2 O2 , the E-peroxone process can considerably increase the efficiency and decrease the energy demand for the abatement of ozone-resistant ECs compared with conventional ozonation...
May 22, 2018: Chemosphere
Mallory S Abate, Sara Shalin
No abstract text is available yet for this article.
May 2018: Cutis; Cutaneous Medicine for the Practitioner
Sampath Gamage, Marquez Howard, Hiroki Makita, Brendan Cross, Gary Hastings, Ming Luo, Yohannes Abate
Enveloped viruses, such as HIV, Ebola and Influenza, are among the most deadly known viruses. Cellular membrane penetration of enveloped viruses is a critical step in the cascade of events that lead to entry into the host cell. Conventional ensemble fusion assays rely on collective responses to membrane fusion events, and do not allow direct and quantitative studies of the subtle and intricate fusion details. Such details are accessible via single particle investigation techniques, however. Here, we implement nano-infrared spectroscopic imaging to investigate the chemical and structural modifications that occur prior to membrane fusion in the single archetypal enveloped virus, influenza X31...
2018: PloS One
Shane C Quinonez, Abate Yeshidinber, Michael A Lourie, Delayehu Bekele, Yemisrach Mekonnen, Balkachew Nigatu, Gesit Metaferia, Solomie Jebessa
PURPOSE: Almost all low-income countries and many middle-income countries lack the capacity to deliver medical genetics services. We developed the MiGene Family History App (MFHA), which assists doctors with family history collection and population-level epidemiologic analysis. The MFHA was studied at St. Paul's Hospital in Addis Ababa, Ethiopia. METHODS: A needs assessment was used to assess Ethiopian physicians' experience with genetics services. The MFHA then collected patient data over a 6-month period...
June 11, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Despina Giannadaki, Elias Giannakis, Andrea Pozzer, Jos Lelieveld
Agricultural ammonia emissions strongly contribute to fine particulate air pollution (PM2.5 ) with significant impacts on human health, contributing to mortality. We used model calculated emission scenarios to examine the health and economic benefits accrued by reducing agricultural emissions. We applied the "value of statistical life" metric to monetize the associated health outcomes. Our analysis indicates that a 50% reduction in agricultural emissions could prevent >200 thousand deaths per year in the 59 countries included in our study, notably in Europe, Russia, Turkey, the US, Canada and China, accompanied with economic benefits of many billions US$...
May 1, 2018: Science of the Total Environment
Jennifer E Schollée, Marc Bourgin, Urs von Gunten, Christa S McArdell, Juliane Hollender
Ozonation and subsequent post-treatments are increasingly implemented in wastewater treatment plants (WWTPs) for enhanced micropollutant abatement. While this technology is effective, micropollutant oxidation leads to the formation of ozonation transformation products (OTPs). Target and suspect screening provide information about known parent compounds and known OTPs, but for a more comprehensive picture, non-target screening is needed. Here, sampling was conducted at a full-scale WWTP to investigate OTP formation at four ozone doses (2, 3, 4, and 5 mg/L, ranging from 0...
May 25, 2018: Water Research
Ailin Li, Zihao Wu, Tingting Wang, Shaodong Hou, Bangjie Huang, Xiujuan Kong, Xuchun Li, Yinghong Guan, Rongliang Qiu, Jingyun Fang
The abatement of pharmaceuticals and personal care products (PPCPs), including carbamazepine (CBZ), acetaminophen (ACP) and sulfamethoxazole (SMX), by zero-valent iron (Fe°) activated peroxydisulfate (PDS) system (Fe°/PDS) in pure water and groundwater was investigated. The removal rates of CBZ, ACP and SMX were 85.4%, 100% and 73.1%, respectively, within 10 min by Fe°/PDS in pure water. SO4 •- , • OH and O2 •- were identified in the Fe°/PDS system, and O2 •- was indicated to play an important role in the ACP degradation...
June 3, 2018: Journal of Hazardous Materials
Benjamin Demaree, Daniel Weisgerber, Freeman Lan, Adam R Abate
Sequencing technologies have undergone a paradigm shift from bulk to single-cell resolution in response to an evolving understanding of the role of cellular heterogeneity in biological systems. However, single-cell sequencing of large populations has been hampered by limitations in processing genomes for sequencing. In this paper, we describe a method for single-cell genome sequencing (SiC-seq) which uses droplet microfluidics to isolate, amplify, and barcode the genomes of single cells. Cell encapsulation in microgels allows the compartmentalized purification and tagmentation of DNA, while a microfluidic merger efficiently pairs each genome with a unique single-cell oligonucleotide barcode, allowing >50,000 single cells to be sequenced per run...
May 23, 2018: Journal of Visualized Experiments: JoVE
Tina T Thomas, Sahiti Chukkapalli, Raelene A Van Noord, Melanie Krook, Mark J Hoenerhoff, Jonathan R Dillman, Elizabeth R Lawlor, Valerie P Opipari, Erika A Newman
Preclinical testing of anticancer therapies relies on relevant xenograft models that mimic the innate tendencies of cancer. Advantages of standard subcutaneous flank models include procedural ease and the ability to monitor tumor progression and response without invasive imaging. Such models are often inconsistent in translational clinical trials and have limited biologically relevant characteristics with low proclivity to produce metastasis, as there is a lack of a native microenvironment. In comparison, orthotopic xenograft models at native tumor sites have been shown to mimic the tumor microenvironment and replicate important disease characteristics such as distant metastatic spread...
May 25, 2018: Journal of Visualized Experiments: JoVE
G Giusti, M Lucci Chiarissi, D Abate, G De Vita, S Angioni, A De Lisa
OBJECTIVES: To verify the feasibility and effectiveness of the correction of Vesicovaginal fistulae (VVF) through a laparoscopic transperitoneal extravesical approach and TachoSil application as interposition tissue. VVF are the most common fistulae of the urinary tract and even today there is no agreement over the preferred approach to treat this kind of pathologic condition. METHODS: We retrospectively analysed the data of women who, from July 2010 to July 2017, underwent early laparoscopic transperitoneal extravesical VVF repair...
June 6, 2018: Urology
Geoffrey J Lipsett-Moore, Nicholas H Wolff, Edward T Game
Savanna fires produce significant emissions globally, but if managed effectively could provide an important mitigation opportunity, particularly in African least developed countries. Here we show global opportunities for emissions reductions through early dry season burning for 37 countries including: 29 countries in Africa (69.1 MtCO2 -e yr-1 ), six countries in South America (13.3 MtCO2 -e yr-1 ), and Australia and Papua New Guinea (6.9 MtCO2 -e yr-1 ). Emissions reduction estimates are based on the successful approach developed in Australia to reduce emissions from savanna fires using global-scale, remotely sensed estimates of monthly emissions...
June 8, 2018: Nature Communications
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