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Georgia Abate, Sandra Colazingari, Alessandra Accoto, David Conversi, Arturo Bevilacqua
Memory consolidation is a dynamic process that involves a sequential remodeling of hippocampal-cortical circuits. Although synaptic events underlying memory consolidation are well assessed, fine molecular events controlling this process deserve further characterization. To this aim, we challenged male C57BL/6N mice in a contextual fear conditioning (CFC) paradigm and tested their memory 24 h, 7 days or 36 days later. Mice displayed a strong fear response at all time points with an increase in dendritic spine density and protein levels of the cell adhesion factor EphrinB2 in CA1 hippocampal neurons 24 h and 7 days post conditioning (p...
February 11, 2018: Behavioural Brain Research
F Carniato, C Bisio, C Evangelisti, R Psaro, V Dal Santo, D Costenaro, L Marchese, M Guidotti
A class of heterogeneous catalysts based on commercial bentonite from natural origin, containing at least 80 wt% of montmorillonite clay, was designed to transform selectively and under mild conditions toxic organosulfur and organophosphorus chemical warfare agents into non-noxious products with a reduced impact on health and environment. The bentonite from the natural origin was modified by introducing iron species and acid sites in the interlayer space, aiming to obtain a sorbent with strong catalytic oxidising and hydrolytic properties...
February 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Cyrille L Delley, Leqian Liu, Maen F Sarhan, Adam R Abate
The transcriptome and proteome encode distinct information that is important for characterizing heterogeneous biological systems. We demonstrate a method to simultaneously characterize the transcriptomes and proteomes of single cells at high throughput using aptamer probes and droplet-based single cell sequencing. With our method, we differentiate distinct cell types based on aptamer surface binding and gene expression patterns. Aptamers provide advantages over antibodies for single cell protein characterization, including rapid, in vitro, and high-purity generation via SELEX, and the ability to amplify and detect them with PCR and sequencing...
February 13, 2018: Scientific Reports
Peter A Forsyth, Daniel Abate-Daga
No abstract text is available yet for this article.
February 13, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Gang Li, Keyu Liu, Xinhui Du
PURPOSE: Long non-coding RNA taurine upregulated gene 1 (TUG1) is reported to be a vital regulator of the progression of various cancers. This study aimed to explore the exact roles and molecular mechanisms of TUG1 in osteosarcoma (OS) development. MATERIALS AND METHODS: Real-time quantitative PCR was applied to detect the expressions of TUG1 and microRNA-132-3p (miR-132-3p) in OS tissues and cells. Western blot was performed to measure protein levels of sex determining region Y-box 4 (SOX4)...
March 2018: Yonsei Medical Journal
Gustavo G Martos, Alicia Mamani, María P Filippone, Pedro O Abate, Néstor E Katz, Atilio P Castagnaro, Juan C Díaz Ricci
Plant secondary metabolism produces a variety of tannins that have a wide range of biological activities, including activation of plant defenses and antimicrobial, anti-inflammatory and antitumoral effects. The ellagitannin HeT (1- O -galloyl-2,3;4,6-bis-hexahydroxydiphenoyl-β-d-glucopyranose) from strawberry leaves elicits a strong plant defense response, and exhibits antimicrobial activity associated to the inhibition of the oxygen consumption, but its mechanism of action is unknown. In this paper we investigate the influence of HeT on bacterial cell membrane integrity and its effect on respiration...
February 2018: FEBS Open Bio
I Fodor, Zs Abonyi-Tóth, L Ózsvári
As a result of the increase in herd size and the intensification of production, the complexity of reproductive management has been growing in dairy herds. The aim of our study was to examine the associations of management practices and reproductive performance in Holstein cows on large commercial dairy farms. Management practices applied to cows were surveyed between 22 May and 6 November 2015 in 34 large Holstein-Friesian dairy herds in Hungary. Individual data of 23 784 cows that calved between 1 January 2014 and 31 December 2014 in the surveyed herds were gathered...
February 13, 2018: Animal: An International Journal of Animal Bioscience
Fei Yang, Ying Huang, Changling Fang, Ying Xue, Luoyan Ai, Jianshe Liu, Zhaohui Wang
Both Cl- and base can affect PMS activation to produce reactive chlorine or oxygen species, but the overall effects of chloride on this emerging PMS/base technology in saline wastewater treatment are unknown. Here effectiveness of PMS/base, PMS/Cl- and PMS/base/Cl- is compared with a gradient concentration of chloride and alkalinity, by probing the degradation of methylene blue (MB). Both PMS/base and PMS/Cl- systems can rapidly degrade MB due to the generation of singlet oxygen and reactive chlorine, respectively...
February 6, 2018: Chemosphere
Jorge Velázquez-Castro, Andrés Anzo-Hernández, Beatriz Bonilla-Capilla, Moisés Soto-Bajo, Andrés Fraguela-Collar
There are economic and physical limitations when applying prevention and control strategies for urban vector borne diseases. Consequently, there are increasing concerns and interest in designing efficient strategies and regulations that health agencies can follow in order to reduce the imminent impact of viruses like Dengue, Zika and Chikungunya. That includes fumigation, abatization, reducing the hatcheries, picking up trash, information campaigns. A basic question that arise when designing control strategies is about which and where these ones should focus...
February 12, 2018: PLoS Neglected Tropical Diseases
Jiwei Li, Bing Chen, Ana M Sánchez de la Campa, Andrés Alastuey, Xavier Querol, Jesus D de la Rosa
Particulate matter with a diameter of 10 μm or less (PM10) using receptor modelling was determined at an urban (La Linea, LL) and an industrial area (Puente Mayorga, PMY) in Southern Spain with samples collected during 2005-2014. The concentrations of PM10 had been decreasing at both sites in three distinctive periods: 1) the initial PM10 levels approached or exceeded the Spain and EU PM10 annual guidelines of 40 μg/m3 during 2005-2007 at LL and 2005-2009 at PMY; 2) then PM10 dropped by 25%-∼30 μg/m3 during 2008-2011 at LL and during 2010-2011 at PMY; 3) since 2012, the PM10 concentrations gradually decreased to <30 μg/m3...
February 8, 2018: Environmental Pollution
WeiJian Liu, YunSong Xu, WenXin Liu, QingYang Liu, ShuangYu Yu, Yang Liu, Xin Wang, Shu Tao
Emissions of air pollutants from primary and secondary sources in China are considerably higher than those in developed countries, and exposure to air pollution is main risk of public health. Identifying specific particulate matter (PM) compositions and sources are essential for policy makers to propose effective control measures for pollutant emissions. Ambient PM2.5 samples covered a whole year were collected from three coastal cities of the Bohai Sea. Oxidative potential (OP) was selected as the indicator to characterize associated PM compositions and sources most responsible for adverse impacts on human health...
February 8, 2018: Environmental Pollution
Gu Gong, Liang Yin, Libang Yuan, Daming Sui, Yangyang Sun, Haiyu Fu, Liang Chen, Xiaowu Wang
High altitude cerebral edema (HACE) is a severe type of acute mountain sickness (AMS) that occurs in response to a high altitude hypobaric hypoxic (HH) environment. GM1 monosialoganglioside can alleviate brain injury under adverse conditions including amyloid-β-peptide, ischemia and trauma. However, its role in HACE-induced brain damage remains poorly elucidated. In this study, GM1 supplementation dose-dependently attenuated increase in rat brain water content (BWC) induced by hypobaric chamber (7600 m) exposurefor 24 h...
February 8, 2018: Molecular Immunology
V Poza-Nogueiras, M Arellano, E Rosales, M Pazos, E González-Romero, M A Sanromán
Conventional water treatments are generally inadequate for degradation of emerging pollutants such as ionic liquids (ILs). The use of heterogeneous electro-Fenton (HEF) has attracted great interest, due to its ability to efficiently oxidize a wide range of organic pollutants operating in cycles or in continuous mode. In this study, the removal of a complex IL from the imidazolinium family (1,3-Bis(2,4,6-trimethylphenyl)imidazolinium chloride), by means of HEF using iron alginate spheres as catalyst has been investigated, resulting in significant TOC decay after 6 h...
February 8, 2018: Chemosphere
Mostafa A Rabie, Mai A Abd El Fattah, Noha N Nassar, Hanan S El-Abhar, Dalaal M Abdallah
MAS receptor (MASR), expressed in several brain areas, conferred neuroprotection against neurodegenerative disorders when activated by angiotensin (Ang) 1-7; however, its role in Parkinson's disease (PD) remains elusive. Intra-striatal post-administration of Ang1-7, using a 6-hydroxydopamine (OHDA) PD model, improved motor performance and muscle coordination. On the molecular level, Ang1-7 upregulated the striatal expression of MASR and caused upsurge in its downstream targets (p-PI3K/p-Akt/p-CREB/BDNF) to phosphorylate TrKB, which in a positive feedback upregulates MASR...
February 8, 2018: Biochemical Pharmacology
Basilius Thalmann, Urs von Gunten, Ralf Kaegi
Ozonation can be applied to mitigate the discharge of organic micropollutants from municipal wastewater treatment plants (WWTPs) to the aquatic environment. The toxicity of metals also present in WWTP effluents strongly depends on their speciation. Therefore, knowledge on the change of the metal speciation during ozonation of a WWTP effluent is essential to assess possible negative impacts. The kinetics and the stoichiometries of the reactions of ozone with three metal sulfides (ZnS, CuS and CdS) and metal-ethylenediaminetetraacetate (EDTA)/nitriloriacetic acid (NTA) complexes of Cu(II), Cd(II), Ni(II), Zn(II), Mg(II) and Pb(II) were investigated...
February 6, 2018: Water Research
Badreldin H Ali, Mohammed Al Za'abi, Turan Karaca, Yousuf Al Suleimani, Khalid A Al Balushi, Priyadarsini Manoj, Mohammed Ashique, Abderrahim Nemmar
Potassium bromate (KBrO3) is used in many countries in cosmetic and food industries. In this work, we investigated in male Sprague-Dawley rats, the effect of four graded oral doses of KBrO3 (5, 15, 45 and 135 mg/kg/day for 28 days) on renal function tests, inflammation, oxidative damage, and apoptosis, as well as on histopathology, using several traditional and novel renal injury biomarkers in plasma, urine and renal tissues. We also tested the possible ameliorative action of the renoprotective prebiotic agent gum acacia (GA) on the actions of KBrO3 when given concomitantly with it in the drinking water at a concentration of 15%w/v...
2018: American Journal of Translational Research
Gabriela Coria, Tzayam Pérez, Ignasi Sirés, Enric Brillas, José L Nava
The degradation of solutions of the antibiotic levofloxacin (LVN) in sulfate medium at pH 3.0 has been investigated at pre-pilot scale by solar photoelectro-Fenton (SPEF) process. The flow plant included an FM01-LC filter-press cell equipped with a Ti|Pt anode and a three-dimensional-like air-diffusion cathode, connected to a compound parabolic collector as photoreactor and a continuous stirred tank under recirculation batch mode. The effect of volumetric flow rate on H2O2 electrogeneration from O2 reduction was assessed...
February 1, 2018: Chemosphere
Hailemichael Zeru Hishe, Tamrat Abate Ambech, Mebrahtom Gebrelibanos Hiben, Biruk Sintayehu Fanta
ETHNOPHARMACOLOGICAL RELEVANCE: Senna singueana (Del.) Lock (Fabaceae) is a shrub or tree found in Ethiopia and other African countries. It has been traditionally used for different conditions including treatment of pain conditions in humans and animals. Although various reports are available in the literature claiming different activities of the plant, scientific studies supporting analgesic potential of S. singueana are lacking and the present study aimed to investigate the antinociceptive effect of methanol extract of leaves of S...
February 5, 2018: Journal of Ethnopharmacology
Qiang Li, Han Zhao, Sizhan Xia, Hanxiao Wei, Feifei Chen, Peisheng Jin
Epithelial differentiation of adipose-derived stem cells (ADSCs) is mediated by sophisticated interactions of various molecular functions and biological processes, including transcriptional regulation. Runt-related transcription factor 2 (RUNX2) increases osteoblast and adipocyte differentiation of ADSCs. However, the role of RUNX2 in epithelial differentiation of ADSCs is unknown. We first showed that ADSCs possess the potential to differentiate into epithelial lineage. Then, we employed the effect of RUNX2 on epithelial differentiation of ADSCs...
January 5, 2018: Oncotarget
Erangu Purath Mohankumar Sajeev, Wilfried Winiwarter, Barbara Amon
Farm livestock manure is an important source of ammonia and greenhouse gases. Concerns over the environmental impact of emissions from manure management have resulted in research efforts focusing on emission abatement. However, questions regarding the successful abatement of manure-related emissions remain. This study uses a meta-analytical approach comprising 89 peer-reviewed studies to quantify emission reduction potentials of abatement options for liquid manure management chains from cattle and pigs. Analyses of emission reductions highlight the importance of accounting for interactions between emissions...
January 2018: Journal of Environmental Quality
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