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https://www.readbyqxmd.com/read/28738392/multiple-lymph-node-basin-drainage-in-trunk-melanoma-is-not-associated-with-survival-of-sentinel-lymph-node-positive-patients
#1
Simone Ribero, Simona Osella Abate, Sadro Pasquali, Carlo Riccardo Rossi, Lorenzo Borgognoni, Dario Piazzalunga, Nicola Solari, Mauro Schiavon, Paola Brandani, Luca Ansaloni, Erica Ponte, Francesco Silan, Antonio Sommariva, Francesco Bellucci, Giuseppe Macripò, Pietro Quaglino
OBJECTIVES: This study was aimed at investigating the prognostic role of multiple lymph node basin drainage (MLBD) in patients with positive sentinel lymph node (SLN) biopsy. BACKGROUND: MLBD is frequently observed in patients with trunk melanoma undergoing SLN. The prognostic value of MLBD in SLN-positive patients is still debated. METHODS: Retrospective data from 312 trunk melanoma patients with positive SLN biopsy (1991-2012) at 6 Italian referral centres were gathered in a multicentre database...
July 25, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28736544/non-suicidal-self-injury-in-eating-disordered-patients-associations-with-heart-rate-variability-and-state-trait-anxiety
#2
Cristina Giner-Bartolome, Núria Mallorquí-Bagué, Iris Tolosa-Sola, Trevor Steward, Susana Jimenez-Murcia, Roser Granero, Fernando Fernandez-Aranda
Background: Non-suicidal self-injury (NSSI) is commonly present in individuals with eating disorders (EDs) and is often employed as a maladaptive emotion regulation strategy to avoid or abate negative emotions. One of the most prevalent negative emotions experienced by self-injurers is anxiety; however, this emotion has not been extensively studied in this population. Thus, the aim of our study was to investigate the influence of anxiety on NSSI in patients with ED from two different dimensions: state anxiety and trait anxiety...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28736050/effects-of-aeration-and-leachate-recirculation-on-methyl-mercaptan-emissions-from-landfill
#3
Siyuan Zhang, Yuyang Long, Yuan Fang, Yao Du, Weijia Liu, Dongsheng Shen
The issue of odorous volatile organic sulfur compound methyl mercaptan (MM) released from landfill sites cannot be ignored for its extremely low odor threshold and high toxicity. In this study, we focused on the formation and emission of MM in four lab-scaled simulated landfill reactors running in different operation modes, namely, R1 and R2, without leachate recirculation, running under anaerobic and semi-aerobic atmosphere, R3 and R4, with leachate recirculation, running under anaerobic and semi-aerobic atmosphere, respectively...
July 20, 2017: Waste Management
https://www.readbyqxmd.com/read/28735367/short-term-and-long-term-effects-of-diazepam-on-the-memory-for-discrimination-and-generalization-of-scopolamine
#4
C Casasola-Castro, L Weissmann-Sánchez, E Calixto-González, A Aguayo-Del Castillo, D N Velázquez-Martínez
Benzodiazepines are among the most widely prescribed and misused psychopharmaceutical drugs. Although they are well-tolerated, they are also capable of producing amnestic effects similar to those observed after pharmacological or organic cholinergic dysfunction. To date, the effect of benzodiazepine diazepam on the memory for discrimination of anticholinergic drugs has not been reported. The aim of the present study was to analyze the immediate and long-term effects of diazepam on a drug discrimination task with scopolamine...
July 22, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28732400/solar-photocatalytic-disinfection-of-agricultural-pathogenic-fungi-curvularia-sp-in-real-urban-wastewater
#5
Yelitza Aguas, Margarita Hincapie, Pilar Fernández-Ibáñez, María Inmaculada Polo-López
The interest in developing alternative water disinfection methods that increase the access to irrigation water free of pathogens for agricultural purposes is increasing in the last decades. Advanced Oxidation Processes (AOPs) have been demonstrated to be very efficient for the abatement of several kind of pathogens in contaminated water. The purpose of the current study was to evaluate and compare the capability of several solar AOPs for the inactivation of resistant spores of agricultural fungi. Solar photoassisted H2O2, solar photo-Fenton at acid and near-neutral pH, and solar heterogeneous photocatalysis using TiO2, with and without H2O2, have been studied for the inactivation of spores of Curvularia sp...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28732308/ripk3-induces-mitochondrial-apoptosis-via-inhibition-of-fundc1-mitophagy-in-cardiac-ir-injury
#6
Hao Zhou, Pingjun Zhu, Jun Guo, Nan Hu, Shuyi Wang, Dandan Li, Shunying Hu, Jun Ren, Feng Cao, Yundai Chen
Ripk3-required necroptosis and mitochondria-mediated apoptosis are the predominant types of cell death that largely account for the development of cardiac ischemia reperfusion injury (IRI). Here, we explored the effect of Ripk3 on mitochondrial apoptosis. Compared with wild-type mice, the infarcted area in Ripk3-deficient (Ripk3(-/-)) mice had a relatively low abundance of apoptotic cells. Moreover, the loss of Ripk3 protected the mitochondria against IRI and inhibited caspase9 apoptotic pathways. These protective effects of Ripk3 deficiency were relied on mitophagy activation...
July 13, 2017: Redox Biology
https://www.readbyqxmd.com/read/28727755/no-abatement-of-steroid-injections-for-tennis-elbow-in-australian-general-practice-a-15-year-observational-study-with-random-general-practitioner-sampling
#7
Bill Vicenzino, Helena Britt, Allan J Pollack, Michelle Hall, Kim L Bennell, David J Hunter
OBJECTIVE: Evaluate general practitioner (GP) management of tennis elbow (TE) in Australia. METHODS: Data about the management of TE by GPs from 2000 to 2015 were extracted from the Bettering the Evaluation of Care of Health program database. Patient and GP characteristics and encounter management data were classified by the International Classification of Primary Care, version 2, and reported using descriptive statistics with point estimates and 95% confidence intervals...
2017: PloS One
https://www.readbyqxmd.com/read/28722107/the-peritoneum-healing-immunity-and-diseases
#8
REVIEW
Annalisa Capobianco, Lucia Cottone, Antonella Monno, Angelo A Manfredi, Patrizia Rovere-Querini
The peritoneum defines a confined microenvironment, which is stable under normal conditions, but is exposed to the damaging effect of infections, surgical injuries, and other neoplastic and non-neoplastic events. Its response to damage includes the recruitment, proliferation and activation of a variety of haematopoietic and stromal cells. In physiologic conditions, effective responses to injuries are organized, inflammatory triggers are eliminated, inflammation quickly abates, and the normal tissue architecture is restored...
July 19, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28721043/preparation-of-exenatide-loaded-linear-poly-ethylene-glycol-brush-poly-l-lysine-block-copolymer-potential-implications-on-diabetic-nephropathy
#9
Fei Tong
The poly(ethylene glycol)-b-brush poly(l-lysine) polymer (PEG-b-(PELG50-g-PLL3)) was synthesized and evaluated as a nanocarrier for prolonging delivery of exenatide through the abdominal subcutaneous injection route. The isoelectric point of exenatide was 4.86, and exenatide could combine with PEG-b-(PELG50-g-PLL3) polymers via electrostatic interactions at pH 7.4. This polymer was a good candidate for achieving prolonged drug delivery for exenatide, considering its high molecular weight. Besides the physicochemical characterization of the polymer, in vitro and in vivo applications were researched as a sustained exenatide delivery system...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28715774/model-elucidating-the-sources-and-formation-mechanisms-of-severe-haze-pollution-over-northeast-mega-city-cluster-in-china
#10
Ting Yang, Alex Gbaguidi, Pingzhong Yan, Wending Zhang, Lili Zhu, Xuefeng Yao, Zifa Wang, Hui Chen
Recent studies on regional haze pollution over China come up in general with strong variability of main causes of heavy polluted episodes, in linkage with local specificities, sources and pollution characteristics. This paper therefore aims at elucidating the main specific sources and formation mechanisms of observed strong haze pollution episodes over 1-15 November 2015 in Northeast region considered as one of biggest megacity clusters in China. The Northeast China mega-city cluster, including Heilong Jiang, Jilin and Liaoning provinces, is adjacent to Russia in the north, Mongolian at the west, North Korea at east, and representing key geographical location in the regional and transnational air pollution issues in China due to the presence of heavy industries and intense economic activities...
July 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28715737/static-and-continuous-flow-through-pulsed-light-technology-for-pesticide-abatement-in-water
#11
Ana Beatriz Baranda, Amaia Lasagabaster, Iñigo Martínez de Marañón
Perspectives concerning pulsed light (PL) technology as a novel water decontamination treatment are overviewed in this work. Degradation of atrazine, malathion, chlorpyriphos-methyl and bromopropylate in aqueous solutions at different concentrations was performed employing static and continuous flow-through PL units. Results for both PL systems were compared in terms of efficacy of pesticides degradation and derived photoproducts formed. The pesticides degradation increased with the applied total fluence for both PL systems...
July 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28715384/the-effect-of-interfacial-chemical-bonding-in-tio2-sio2-composites-on-their-photocatalytic-nox-abatement-performance
#12
Amer Hakki, Lu Yang, Fazhou Wang, Donald E Macphee
The chemical bonding of particulate photocatalysts to supporting material surfaces is of great importance in engineering more efficient and practical photocatalytic structures. However, the influence of such chemical bonding on the optical and surface properties of the photocatalyst and thus its photocatalytic activity/reaction selectivity behavior has not been systematically studied. In this investigation, TiO2 has been supported on the surface of SiO2 by means of two different methods: (i) by the in situ formation of TiO2 in the presence of sand quartz via a sol-gel method employing tetrabutyl orthotitanium (TBOT); and (ii) by binding the commercial TiO2 powder to quartz on a surface silica gel layer formed from the reaction of quartz with tetraethylorthosilicate (TEOS)...
July 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28713670/in-vitro-experimental-models-of-mesothelioma-revisited
#13
REVIEW
Anand Singh, Nathanael Pruett, Chuong D Hoang
Malignant pleural mesothelioma (MPM) is a biologically unusual, highly aggressive cancer that defies current multimodality treatments. Epidemiologic data suggest that this malignancy has not abated despite increasingly strict environmental regulations on asbestos, the putative causative agent for sporadic cases. An incomplete understanding of all the factors mechanistically driving mesothelioma is largely responsible for the current lack of curative treatments. Many approaches have been employed to ascertain the step-by-step molecular events involved in mesothelioma oncogenesis including in vitro, small animal in vivo, and human experimental models; though clearly defined, druggable mechanisms still are elusive...
June 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28713155/hypoxia-induces-universal-but-differential-drug-resistance-and-impairs-anticancer-mechanisms-of-5-fluorouracil-in-hepatoma-cells
#14
Jing-Qiu Li, Xian Wu, Lu Gan, Xiang-Liang Yang, Ze-Hong Miao
Hepatocellular carcinoma (HCC) is one of the most refractory cancers. The mechanisms by which hypoxia further aggravates therapeutic responses of advanced HCC to anticancer drugs remain to be clarified. Here, we report that hypoxia (1% O2) caused 2.55-489.7-fold resistance to 6 anticancer drugs (sorafenib, 5-fluorouracil [5-FU], gemcitabine, cisplatin, adriamycin and 6-thioguanine) in 3 HCC cell lines (BEL-7402, HepG2 and SMMC-7721). Among the 6 drugs, sorafenib, the sole one approved for HCC therapy, inhibited proliferation with little influence from hypoxia and displayed the smallest variation among the 3 HCC cell lines tested...
July 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28712893/the-glucagon-like-peptide-1-analogue-liraglutide-promotes-autophagy-through-the-modulation-of-5-amp-activated-protein-kinase-in-ins-1-%C3%AE-cells-under-high-glucose-conditions
#15
Xinyu Miao, Zhaoyan Gu, Yu Liu, Mengmeng Jin, Yanhui Lu, Yanping Gong, Lin Li, Chunlin Li
Glucagon-like peptide-1 (GLP-1) is a potent therapeutic agent for the treatment of diabetes and has been proven to protect pancreatic β-cells from glucotoxicity; however, its mechanisms of action are not entirely understood. Autophagy is a dynamic lysosomal degradation process that can protect organisms against metabolic stress. Studies have shown that autophagy plays a protective role in the survival of pancreatic β-cells under high glucose conditions. In the present study, we explored the role of autophagy in GLP-1-induced protection of pancreatic β-cells exposed to high glucose...
July 13, 2017: Peptides
https://www.readbyqxmd.com/read/28709994/metabolic-correction-by-pyruvate-halts-acquired-epilepsy-in-multiple-rodent-models
#16
I Popova, A Malkov, A I Ivanov, E Samokhina, S Buldakova, O Gubkina, A Osypov, R S Muhammadiev, T Zilberter, M Molchanov, S Paskevich, M Zilberter, Y Zilberter
Metabolic intervention strategy of epilepsy treatment has been gaining broader attention due to accumulated evidence that hypometabolism, manifested in humans as reduced brain glucose consumption, is a principal factor in acquired epilepsy. Therefore, targeting deficient energy metabolism may be an effective approach for treating epilepsy. To confront this pathology we utilized pyruvate, which besides being an anaplerotic mitochondrial fuel possesses a unique set of neuroprotective properties as it: (i) is a potent reactive oxygen species scavenger; (ii) abates overactivation of Poly [ADP-ribose] polymerase 1 (PARP-1); (iii) facilitates glutamate efflux from the brain; (iv) augments brain glycogen stores; (v) is anti-inflammatory; (vi) prevents neuronal hyperexcitability; and (vii) normalizes the cytosolic redox state...
July 12, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28709820/sex-dependent-difference-in-the-relationship-between-adipose-tissue-cholesterol-efflux-and-estradiol-concentrations-in-young-healthy-humans
#17
REVIEW
Fatima Iqbal, William J Durham, Ayyash Melhem, Saleem Raslan, Tony T Tran, Traver J Wright, Rabia Asghar, Ken Fujise, Elena Volpi, Labros Sidossis, Nicola Abate, Melinda Sheffield-Moore, Demidmaa Tuvdendorj
BACKGROUND: Impaired adipose tissue function and lower levels of high density lipoprotein cholesterol (HDL-C) have been implicated in the development of vascular dementia, and metabolic diseases such as hypertension, atherosclerosis, type 2 diabetes (T2D) and metabolic syndrome. Interestingly, both the substrate fluxes in adipose tissue and HDL-C concentration differ between men and women. Moreover, adipose tissue cholesterol efflux has been implicated in modulation of HDL-C levels. Thus, we aimed to determine if the association between serum estradiol levels and adipose tissue cholesterol efflux is sex-dependent...
July 11, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28704985/the-large-spectrum-of-spitzoid-tumours-a-retrospective-survival-study
#18
Paolo Broganelli, Simone Ribero, Ilaria Castagno, Fulvio Ricceri, Tommaso Deboli, Elena Marra, Carlo Tomasini, Carlotta Sacerdote, Simona Osella-Abate, Martina Sanlorenzo, Pietro Quaglino, Maria T Fierro
BACKGROUND: There is no universally-accepted classification of spitzoid tumours. This makes difficult to assign a correct diagnosis and select a treatment that minimises the risk of overestimating, or worse, underestimating, the malignant potential of these tumours. To describe the clinical-pathological and epidemiological features of spitzoid tumours, as well as to assess mortality in these patients. METHODS: This retrospective cohort study looked at data on spitzoid tumours excised in 1999-2012 at the Dermatologic Clinic of the Turin University Hospital...
July 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28702196/the-nocturnal-acoustical-intensity-of-the-intensive-care-environment-an-observational-study
#19
Lori J Delaney, Marian J Currie, Hsin-Chia Carol Huang, Violeta Lopez, Edward Litton, Frank Van Haren
BACKGROUND: The intensive care unit (ICU) environment exposes patients to noise levels that may result in substantial sleep disruption. There is a need to accurately describe the intensity pattern and source of noise in the ICU in order to develop effective sound abatement strategies. The objectives of this study were to determine nocturnal noise levels and their variability and the related sources of noise within an Australian tertiary ICU. METHODS: An observational cross-sectional study was conducted in a 24-bed open-plan ICU...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28700812/disparities-in-location-of-death-of-adolescents-and-young-adults-with-cancer-a-longitudinal-population-study-in-california
#20
Nitya Rajeshuni, Emily E Johnston, Olga Saynina, Lee M Sanders, Lisa J Chamberlain
BACKGROUND: Patients with a terminal illness should have access to their chosen location of death. Cancer is the leading cause of non-accidental death among adolescents and young adults (AYAs; those aged 15-39 years). Although surveys have suggested that a majority of these patients prefer a home death, to the authors' knowledge, little is known regarding their barriers to accessing their preferred location of death. As a first step, the authors sought to determine, across a large population, 20-year trends in the location of death among AYA patients with cancer...
July 12, 2017: Cancer
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