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https://www.readbyqxmd.com/read/29679541/treatment-with-d-%C3%AE-hydroxybutyrate-protects-heart-from-ischemia-reperfusion-injury-in-mice
#1
Yongsheng Yu, Yunhua Yu, Yuefan Zhang, Zhigang Zhang, Weishuai An, Xianxian Zhao
The present study was designed to examine the protection of D-β-hydroxybutyrate (BHB) against ischemia/reperfusion (I/R) injury in heart and investigate its underlying mechanism. Male adult mice were exposed to 30min of ischemia and 24h of reperfusion. Osmotic pumps were implanted subcutaneously 5min before reperfusion for continuous delivery of the exogenous BHB (1.6mmol/kg/24h). Treatment with BHB reduced infarct size and levels of cardiac troponin I, creatine kinase and lactate dehydrogenase in serum, attenuated apoptosis in myocardium, and preserved cardiac function of I/R mice...
April 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29678541/b-1-non-uniformity-correction-of-phased-array-coils-without-measuring-coil-sensitivity
#2
Frederick C Damen, Kejia Caic
Parallel imaging can be used to increase SNR and shorten acquisition times, albeit, at the cost of image non-uniformity. B1 - non-uniformity correction techniques are confounded by signal that varies not only due to coil induced B1 - sensitivity variation, but also the object's own intrinsic signal. Herein, we propose a method that makes minimal assumptions and uses only the coil images themselves to produce a single combined B1 - non-uniformity-corrected complex image with the highest available SNR. A novel background noise classifier is used to select voxels of sufficient quality to avoid the need for regularization...
April 17, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29677221/a-2015-outbreak-of-flea-borne-rickettsiosis-in-san-gabriel-valley-los-angeles-county-california
#3
Kimberly Nelson, Alice N Maina, Angela Brisco, Chelsea Foo, Curtis Croker, Van Ngo, Rachel Civen, Allen L Richards, Kenn Fujioka, J Wakoli Wekesa
Although flea-borne rickettsiosis is endemic in Los Angeles County, outbreaks are rare. In the spring of 2015 three human cases of flea-borne rickettsiosis among residents of a mobile home community (MHC) prompted an investigation. Fleas were ubiquitous in common areas due to presence of flea-infested opossums and overabundant outdoor cats and dogs. The MHC was summarily abated in June 2015, and within five months, flea control and removal of animals significantly reduced the flea population. Two additional epidemiologically-linked human cases of flea-borne rickettsiosis detected at the MHC were suspected to have occurred before control efforts began...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29676546/alginate-catechol-cross-linking-interferes-with-insulin-secretion-capacity-in-isolated-murine-islet-cells
#4
Yu Sik Kim, Seung Woo Cho, Bomin Ko, Jisoo Shin, Chul Woo Ahn
Over the past three decades, human pancreatic islet isolation and transplantation techniques have developed as a routine clinical procedure for selected patients with type 1 diabetes mellitus. However, due to the donor shortage and required chronic systemic immunosuppression, the widespread application of islet transplantation is limited. To overcome these limitations, providing a physical barrier to transplanted islet cells with encapsulating biomaterial has emerged as a promising approach to enhance engraftment and promote islet survival post-transplantation...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29675132/honokiol-ameliorates-myocardial-ischemia-reperfusion-injury-in-type-1-diabetic-rats-by-reducing-oxidative-stress-and-apoptosis-through-activating-the-sirt1-nrf2-signaling-pathway
#5
Bin Zhang, Mengen Zhai, Buying Li, Zhenhua Liu, Kaifeng Li, Liqing Jiang, Meng Zhang, Wei Yi, Jian Yang, Dinghua Yi, Hongliang Liang, Zhenxiao Jin, Weixun Duan, Shiqiang Yu
Reducing oxidative stress is a crucial therapeutic strategy for ameliorating diabetic myocardial ischemia/reperfusion (MI/R) injury. Honokiol (HKL) acts as an effective cardioprotective agent for its strong antioxidative activity. However, its roles and underlying mechanisms against MI/R injury in type 1 diabetes (T1D) remain unknown. Since SIRT1 and Nrf2 are pivotal regulators in diabetes mellitus patients suffering from MI/R injury, we hypothesized that HKL ameliorates diabetic MI/R injury via the SIRT1-Nrf2 signaling pathway...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29674741/pair-bond-endurance-promotes-cooperative-food-defense-and-inhibits-conflict-in-coral-reef-butterflyfish
#6
Jessica P Nowicki, Stefan P W Walker, Darren J Coker, Andrew S Hoey, Katia J Nicolet, Morgan S Pratchett
Pair bonding is generally linked to monogamous mating systems, where the reproductive benefits of extended mate guarding and/or of bi-parental care are considered key adaptive functions. However, in some species, including coral reef butterflyfishes (f. Chaetodonitidae), pair bonding occurs in sexually immature and homosexual partners, and in the absence of parental care, suggesting there must be non-reproductive adaptive benefits of pair bonding. Here, we examined whether pair bonding butterflyfishes cooperate in defense of food, conferring direct benefits to one or both partners...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674263/electro-fenton-process-for-implementation-of-acid-black-liquor-waste-treatment
#7
Gabriel Buftia, Emilio Rosales, Marta Pazos, Gabriel Lazar, María Angeles Sanromán
In this work, an eco-friendly solution for the remediation of wastewater generated in the lignin recovery process from eco-industrial paper mill has been proposed in their way towards a more circular economy strategy. Thus, the application of the electro-Fenton process for the degradation of the non-recovered lignin and other organic compounds form a scarcely studied acid black liquor waste (ABLW) was successfully performed. This treatment was able to operate in a range of COD loads (0.5-19.5mgO2 ·L-1 ) showing high degradation values of the ABLW determined by the abatement of color, total phenolic content and COD...
April 16, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29672032/oxidation-processes-in-water-treatment-are-we-on-track
#8
Urs von Gunten
Chemical oxidants have been applied in water treatment for more than a century, first as disinfectants and later to abate inorganic and organic contaminants. The challenge of oxidative abatement of organic micropollutants is the formation of transformation products with unknown (eco)toxicological consequences. Four aspects need to be considered for oxidative micropollutant abatement: (i) Reaction kinetics, controlling the efficiency of the process, (ii) mechanisms of transformation product formation, (iii) extent of formation of disinfection byproducts from the matrix, (iv) oxidation induced biological effects, resulting from transformation products and/or disinfection byproducts...
April 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29670963/comparing-ammonia-diffusion-in-nh-3-scr-zeolite-catalysts-a-quasielastic-neutron-scattering-and-molecular-dynamics-simulation-study
#9
A J O'Malley, M Sarwar, J Armstrong, C R A Catlow, I P Silverwood, A P E York, I Hitchcock
The diffusion of ammonia in the small pore zeolite and potential commercial NH3-SCR catalyst levynite (LEV) was measured and compared with its mobility in the chabazite (CHA) topology (more established in NOx abatement catalysis), using quasielastic neutron scattering (QENS) and molecular dynamics (MD) simulations at 273, 323 and 373 K. The QENS experiments suggest that mobility in LEV is dominated by jump diffusion through the 8-ring windows between cages (as previously observed in CHA) which takes place at very similar rates in the two zeolites, yielding similar experimental self-diffusion coefficients (Ds)...
April 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29667463/performance-of-protein-induced-by-vitamin-k-absence-or-antagonist-ii-assessed-by-chemiluminescence-enzyme-immunoassay-for-hepatocellular-carcinoma-detection-a-meta-analysis
#10
Gian Paolo Caviglia, Davide Giuseppe Ribaldone, Maria Lorena Abate, Alessia Ciancio, Rinaldo Pellicano, Antonina Smedile, Giorgio Maria Saracco
OBJECTIVES: In the setting of surveillance for hepatocellular carcinoma (HCC) detection, the use of serum biomarkers in addition to ultrasonography (US) is still a matter of debate. Hence, we performed a meta-analysis to evaluate the diagnostic accuracy of protein induced by vitamin K absence or antagonist-II (PIVKA-II) and alpha-fetoprotein (AFP) alone or in combination for HCC detection in patients at risk of tumor development. MATERIALS AND METHODS: We performed a systematic search in PubMed and Scopus database for original articles published in English from 2011 to 2017, investigating the accuracy of PIVKA-II alone or in combination with AFP (reported as area under the curve [AUC]) for HCC detection among patients at risk of tumor development...
April 18, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29661845/lysosome-enlargement-during-inhibition-of-the-lipid-kinase-pikfyve-proceeds-through-lysosome-coalescence
#11
Christopher H Choy, Golam Saffi, Matthew A Gray, Callen Wallace, Roya M Dayam, Zhen-Yi A Ou, Guy Lenk, Rosa Puertollano, Simon C Watkins, Roberto J Botelho
Lysosomes receive and degrade cargo from endocytosis, phagocytosis and autophagy. They also play an important role in sensing and instructing cells on their metabolic state. The lipid kinase PIKfyve generates phosphatidylinositol-3,5-bisphosphate to modulate lysosome function. PIKfyve inhibition leads to impaired degradative capacity, ion dysregulation, abated autophagic flux, and a massive enlargement of lysosomes. Collectively, this leads to various physiological defects including embryonic lethality, neurodegeneration and overt inflammation...
April 16, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29661807/genetically-engineered-mouse-models-of-prostate-cancer-in-the-postgenomic-era
#12
Juan M Arriaga, Cory Abate-Shen
Recent genomic sequencing analyses have unveiled the spectrum of genomic alterations that occur in primary and advanced prostate cancer, raising the question of whether the corresponding genes are functionally relevant for prostate tumorigenesis, and whether such functions are associated with particular disease stages. In this review, we describe genetically engineered mouse models (GEMMs) of prostate cancer, focusing on those that model genomic alterations known to occur in human prostate cancer. We consider whether the phenotypes of GEMMs based on gain or loss of function of the relevant genes provide reliable counterparts to study the predicted consequences of the corresponding genomic alterations as occur in human prostate cancer, and we discuss exceptions in which the GEMMs do not fully emulate the expected phenotypes...
April 16, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29660051/resection-of-right-frontal-arteriovenous-malformation-3-dimensional-operative-video
#13
William T Couldwell
The video demonstrates resection of a Grade II Spetzler-Martin unruptured, medium-sized arteriovenous malformation (AVM). A young woman presented with headaches and seizures. The right frontal lesion measured 4.5 cm in largest dimension and had superficial venous drainage. Partial Onyx embolization, primarily of the anterior cerebral feeding arteries, was performed. Bone removal for exposure allowed identification of indentation from the large superficial draining vein. The video demonstrates careful microsurgical dissection on the AVM/brain interface, with selective interruption of feeding arteries circumferentially...
April 11, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29656453/chlorogenic-acid-protects-against-oxldl-induced-oxidative-damage-and-mitochondrial-dysfunction-by-modulating-sirt1-in-endothelial-cells
#14
Kun-Ling Tsai, Ching-Hsia Hung, Shih-Hung Chan, Pei-Ling Hsieh, Hsiu-Chung Ou, Yung-Hsin Cheng, Pei-Ming Chu
SCOPE: Endothelial dysfunction is an important mechanism in the development of atherosclerosis and is thought to be critical for predicting cardiovascular diseases. Previous reports suggested that Chlorogenic acid (CGA) is a potent antioxidant and anti-inflammatory compound. The molecular mechanisms underlying the inhibitory effects of CGA on oxLDL-induced oxidative injuries in human endothelial cells are still largely unknown. This study aimed to test the hypothesis that CGA protects against oxLDL-facilitated oxidative stress by upregulating SIRT1 and to explore the role of AMPK/PGC-1 pathway and mitochondrial biogenesis...
April 15, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29653047/understanding-electrochemically-activated-persulfate-and-its-application-to-ciprofloxacin-abatement
#15
Laura W Matzek, Matthew J Tipton, Abigail T Farmer, Andrew Steen, Kimberly E Carter
This study offers significant insight into the roles anodic and cathodic processes play in electrochemically-activated persulfate (EAP) and screens EAP as a viable technique for ciprofloxacin degradation in wastewater. Sulfate radical formation at a boron-doped diamond anode and persulfate activation at a graphite cathode were experimentally elucidated using different electrolytes and electrochemical set-ups. Rapid ciprofloxacin transformation occurred via pseudo-first order mechanisms in persulfate electrolyte, reaching 84% removal in 120 minutes using EAP...
April 13, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29651177/potential-of-marine-derived-fungi-to-remove-hexavalent-chromium-pollutant-from-culture-broth
#16
Nikita P Lotlikar, Samir R Damare, Ram Murti Meena, P Linsy, Brenda Mascarenhas
Chromium (Cr) released from industrial units such as tanneries, textile and electroplating industries is detrimental to the surrounding ecosystems and human health. The focus of the present study was to check the Cr(VI) removal efficiency by marine-derived fungi from liquid broth. Amongst the three Cr(VI) tolerant isolates, #NIOSN-SK56-S19 ( Aspergillus sydowii ) showed Cr-removal efficiency of 0.01 mg Cr mg-1 biomass resulting in 26% abatement of total Cr with just 2.8 mg of biomass produced during the growth in 300 ppm Cr(VI)...
June 2018: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29649478/autophagy-alteration-prevents-primary-cilium-disassembly-in-rpe1-cells
#17
Yunash Maharjan, Joon No Lee, SeongAe Kwak, Hyewon Lim, Raghbendra Kumar Dutta, Zhi-Qiang Liu, Hong-Seob So, Raekil Park
Primary cilium is a microtubule structure that emanates from the surface of most human cells. Primary cilia assemble during the resting stage (G0 phase) and disassemble with cell cycle progression. Defects associated with the control of the assembly or disassembly of the primary cilium have been implicated in various human diseases, including ciliopathy and cancer. Although studies have suggested the interplay between activation of autophagy and ciliogenesis, any direct mechanism between autophagy abatement and disassembly of primary cilium remains elusive...
April 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29628573/does-restrictive-fluid-strategy-during-robotic-pelvic-surgeries-obtund-intraoperative-rise-in-intraocular-pressure
#18
Pulak Tosh, Saritha Valsala Krishnankutty, Sunil Rajan, Hema Muraleedharan Nair, Nitu Puthanveettil, Lakshmi Kumar
Background: Robotic pelvic surgeries require steep Trendelenburg position which may result in rise in intraocular pressure (IOP). Aim: The aim of this study was to compare the changes that occur in IOP during robotic pelvic surgeries in steep Trendelenburg position with a restrictive intravenous fluid administration. Settings and Design: This prospective observational study was conducted in a tertiary care institution. Subjects and Methods: Twenty consenting patients scheduled for pelvic robotic gynecological surgeries were enrolled...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29627544/framework-for-the-use-of-odour-wheels-to-manage-odours-throughout-wastewater-biosolids-processing
#19
Ruth M Fisher, Radoslaw J Barczak, I H Mel Suffet, James E Hayes, Richard M Stuetz
Odorous emissions from wastewater biosolids processing can cause nuisance impacts to the surrounding community. Odour Wheels are an effective tool for environmental odour management, but have yet to be provided for wastewater biosolids processing. Emissions throughout the biosolids processing from eight wastewater treatment plants, each with different unit operation configurations, were surveyed to identify odorants present and their olfactory properties. Chemical and olfactory methods identified a range of odorants and odours emitted throughout biosolids processing...
April 5, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29625525/remediation-of-arsenic-in-mung-bean-vigna-radiata-with-growth-enhancement-by-unique-arsenic-resistant-bacterium-acinetobacter-lwoffii
#20
Joyati Das, Priyabrata Sarkar
Arsenic, a carcinogenic and toxic contaminant of soil and water, affects human health adversely. During last few decades, it has been an important global environmental issue. Among several arsenic detoxification methods remediation using arsenic resistant microbes is proved to be environment-friendly and cost-effective. This study aimed to test the effects of arsenic utilizing bacterial strain Acinetobacter lwoffii (RJB-2) on arsenic uptake and growth of mung bean plants (Vigna radiata). RJB-2 exhibited tolerance up to 125mM of arsenic (V) and 50mM of arsenic (III)...
May 15, 2018: Science of the Total Environment
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