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https://www.readbyqxmd.com/read/29765255/distribution-of-pomalidomide-into-semen-of-healthy-male-subjects-after-multiple-doses
#1
Yan Li, Xiaomin Wang, Liangang Liu, Josephine Reyes, Maria Palmisano, Simon Zhou
Objective: To assess whether pomalidomide can distribute into human semen and its duration in human semen. Method: A phase 1, randomized, double-blind, placebo-controlled study (CC-4047-CP-006) was conducted to evaluate the safety, tolerability, and pharmacokinetics of pomalidomide (CC-4047) following multiple daily doses in healthy male subjects. Semen samples were collected on Day -1 and 4 hours after dosing on Day 4 to quantify the pomalidomide concentrations in ejaculate after multiple oral doses of pomalidomide...
2018: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/29747669/role-of-the-general-practitioner-in-improving-rural-healthcare-access-a-case-from-nepal
#2
Bikash Gauchan, Stephen Mehanni, Pawan Agrawal, Mandeep Pathak, Santosh Dhungana
BACKGROUND: There is a global health workforce shortage, which is considered critical in Nepal, a low-income country with a predominantly rural population. General practitioners (GPs) may play a key role improving access to essential health services in rural Nepal, though they are currently underrepresented at the district hospital level. The objective of this paper is to describe how GPs are adding value in rural Nepal by exploring clinical, leadership, and educational roles currently performed in a rural district-level hospital...
May 10, 2018: Human Resources for Health
https://www.readbyqxmd.com/read/29742136/impact-on-birth-weight-and-child-growth-of-participatory-learning-and-action-women-s-groups-with-and-without-transfers-of-food-or-cash-during-pregnancy-findings-of-the-low-birth-weight-south-asia-cluster-randomised-controlled-trial-lbwsat-in-nepal
#3
Naomi M Saville, Bhim P Shrestha, Sarah Style, Helen Harris-Fry, B James Beard, Aman Sen, Sonali Jha, Anjana Rai, Vikas Paudel, Raghbendra Sah, Puskar Paudel, Andrew Copas, Bishnu Bhandari, Rishi Neupane, Joanna Morrison, Lu Gram, Anni-Maria Pulkki-Brännström, Jolene Skordis-Worrall, Machhindra Basnet, Saskia de Pee, Andrew Hall, Jayne Harthan, Meelan Thondoo, Sonja Klingberg, Janice Messick, Dharma S Manandhar, David Osrin, Anthony Costello
BACKGROUND: Undernutrition during pregnancy leads to low birthweight, poor growth and inter-generational undernutrition. We did a non-blinded cluster-randomised controlled trial in the plains districts of Dhanusha and Mahottari, Nepal to assess the impact on birthweight and weight-for-age z-scores among children aged 0-16 months of community-based participatory learning and action (PLA) women's groups, with and without food or cash transfers to pregnant women. METHODS: We randomly allocated 20 clusters per arm to four arms (average population/cluster = 6150)...
2018: PloS One
https://www.readbyqxmd.com/read/29732216/can-the-evolution-of-male-contraception-lead-to-a-revolution-review-of-the-current-state-of-knowledge
#4
Mikołaj Frankiewicz, Wojciech Połom, Marcin Matuszewski
Introduction: Great advances in medical research concerning methods of contraception have been achieved in recent years, however, more than 25% of couples worldwide still rely on condoms - a method with poor efficacy. Even though there is a spectrum of 11 different contraceptive methods for women, there are only 4 commonly used by men (condoms, periodic abstinence, withdrawal and vasectomy). In this review, advances and present, state-of-the-art, both hormonal and non-hormonal male contraceptive methods will be presented and evaluated...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29672554/inhibition-of-sperm-motility-in-male-macaques-with-ep055-a-potential-non-hormonal-male-contraceptive
#5
Michael G O'Rand, Katherine G Hamil, Tiffany Adevai, Mary Zelinski
Men have two practical choices for contraception; the condom which has a high typical use failure rate or vasectomy. New male hormonal and non-hormonal contraceptives are under development that target either the production of sperm (spermatogenesis) or the delivery of sperm. One particular target is the sperm protein EPPIN, which is present on the surface of human spermatozoa. EP055 is a small organic compound that targets EPPIN on the surface of sperm and inhibits motility. EP055 was tested in cynomolgus (Macaca fascicularis) males to determine its plasma half-life after intravenous (i...
2018: PloS One
https://www.readbyqxmd.com/read/29668706/different-managements-for-prepubertal-epididymitis-based-on-a-preexisting-genitourinary-anomaly-diagnosis
#6
Yong Seung Lee, Sang Woon Kim, Sang Won Han
There is no clear consensus regarding investigating for accompanying genitourinary anomalies (GUAs) in patients with prepubertal acute epididymitis (AE). Moreover, risk factors for the recurrence and the need for a surgical intervention have never been discussed. The purpose of this study was to evaluate the different clinical courses of prepubertal AE based on knowledge of preexisting GUAs. Between January 2005 and December 2014, AE was diagnosed in 189 pediatric patients <10 years old. Clinical characteristics and treatments were retrospectively analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29663943/retrospective-review-of-surgical-outcomes-and-pair-housing-success-in-vasectomized-rhesus-macaques-macaca-mulatta
#7
Dilrukshi K Ekanayake-Alper, Steven R Wilson, Jodi A Scholz
Providing social housing for adult male macaques can be challenging. One successful strategy for long-term social housing of adult male macaques is to pair them with adult females; however, unwanted breeding must be prevented by sterilization of the male or female. Vasectomy is a simple, highly effective, and minimally invasive method of contraception that is used at our institution to facilitate social housing. We performed a retrospective review to analyze the surgical outcomes and rate of postoperative complications after vasectomy of adult rhesus macaques at our research facility...
April 2, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29648649/infectious-inflammatory-and-autoimmune-male-factor-infertility-how-do-rodent-models-inform-clinical-practice
#8
Monika Fijak, Adrian Pilatz, Mark P Hedger, Nour Nicolas, Sudhanshu Bhushan, Vera Michel, Kenneth S K Tung, Hans-Christian Schuppe, Andreas Meinhardt
BACKGROUND: Infection and inflammation of the reproductive tract are significant causes of male factor infertility. Ascending infections caused by sexually transmitted bacteria or urinary tract pathogens represent the most frequent aetiology of epididymo-orchitis, but viral, haematogenous dissemination is also a contributory factor. Limitations in adequate diagnosis and therapy reflect an obvious need for further understanding of human epididymal and testicular immunopathologies and their contribution to infertility...
April 10, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29611308/factors-impacting-couples-decision-making-between-vasectomy-reversal-versus-sperm-retrieval-in-vitro-fertilization-intracytoplasmic-sperm-injection
#9
P K Kavoussi, K M Kavoussi, K C Odenwald, S K Kavoussi
The purpose of this study was to identify factors which impact a couples' decision-making between the options of vasectomy reversal vs. sperm retrieval/in vitro fertilization/intracytoplasmic sperm injection when counseled both by a reproductive urologist and a reproductive endocrinologist. A retrospective chart review was performed of couples who wish to achieve a pregnancy with a male partner with a history of prior vasectomy, in a couples' private fertility center. Of patients presenting for fertility options with a history of vasectomy, 175 couples elected to be counseled by both a reproductive urologist and a reproductive endocrinologist on the options between vasectomy reversal and sperm retrieval/in vitro fertilization/intracytoplasmic sperm injection, with 78...
April 2, 2018: Andrology
https://www.readbyqxmd.com/read/29578040/evaluation-of-vasectomy-trends-in-the-united-states
#10
Kevin A Ostrowski, Sarah K Holt, Brandon Haynes, Benjamin J Davies, Eugene F Fuchs, Thomas J Walsh
OBJECTIVE: To use the Truven Health MarketScan® (THM) database to better approximate the annual rate of vasectomies performed in the US population, determine changes over time, regional differences, providers performing this, and if there is any monthly variation in vasectomy rates. MATERIALS & METHODS: Claims data were evaluated from 2007 - 2015 to determine the annual prevalence of vasectomy by patient age and region in the US. The cohort included men aged 18-64 with at least one claim in any given year in THM...
March 22, 2018: Urology
https://www.readbyqxmd.com/read/29566037/association-between-vasectomy-and-risk-of-testicular-cancer-a-systematic-review-and-meta-analysis
#11
Haifeng Duan, Tuo Deng, Yiwen Chen, Zhijian Zhao, Yaoan Wen, Yeda Chen, Xiaohang Li, Guohua Zeng
OBJECTIVES: A number of researchers have reported that vasectomy is a risk factor for testicular cancer. However, this conclusion is inconsistent with a number of other published articles. Hence, we conducted this meta-analysis to assess whether vasectomy increases the risk of testicular cancer. MATERIALS AND METHODS: We identified all related studies by searching the PubMed, Embase, and Cochrane Library database from January 01, 1980 to June 01, 2017. The Newcastle-Ottawa Scale (NOS) checklist was used to assess all included non-randomized studies...
2018: PloS One
https://www.readbyqxmd.com/read/29536014/aggression-toward-familiar-people-strangers-and-conspecifics-in-gonadectomized-and-intact-dogs
#12
Parvene Farhoody, Indika Mallawaarachchi, Patrick M Tarwater, James A Serpell, Deborah L Duffy, Chris Zink
Gonadectomy is widely used to treat and prevent behavior problems including the aggressive behavior of dogs. The aim of this study was to determine whether aggressive behavior toward familiar people, strangers, or other dogs was significantly different in dogs gonadectomized at various ages vs. intact dogs using the Canine Behavioral Assessment Research Questionnaire (C-BARQ) with multivariate analysis. Of 15,370 initial surveys, those for dogs reported to have been gonadectomized at less than 6 weeks of age or to correct a behavior problem, and those with incomplete answers to questions regarding independent or dependent variables were excluded, leaving 13,795 for the analysis of aggressive behavior toward familiar people: 13,498 for aggressive behavior toward strangers and 13,237 for aggressive behavior toward dogs...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29524505/the-effect-of-vasectomy-reversal-on-prostate-cancer-risk-international-meta-analysis-of-684-660-men-with-vasectomies
#13
Sean Randall, James Boyd, Emma Fuller, Caroline Brooks, Carole Morris, Craig C Earle, Anna Ferrante, Rachael Moorin, James Semmens, C D'Arcy J Holman
PURPOSE: Evidence of the effect of vasectomy on prostate cancer is conflicting with the issue of detection bias a key criticism. We examined the effect of vasectomy reversal on prostate cancer risk in a cohort of vasectomized men. Evidence of a protective effect would be consistent with a harmful effect of vasectomy on prostate cancer risk while nullifying the issue of detection bias. MATERIALS AND METHODS: Data were sourced from a total of 5 population level linked health databases in Australia, Canada and the United Kingdom...
March 7, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29463441/perineal-ultrasound-a-review-in-the-context-of-ejaculatory-dysfunction
#14
REVIEW
Connor M Forbes, Ryan Flannigan, Darius A Paduch
BACKGROUND: Ejaculation consists of the emission of semen from seminal vesicles and prostate, followed by expulsion. Ejaculatory dysfunction may take several forms including premature ejaculation, delayed or anejaculation, retrograde ejaculation, and painful ejaculation. Ejaculation is what we can see whereas orgasm is what we feel. The presence of ejaculate does not indicate the ability to experience orgasm. Hence, for the purpose of this work we consider orgasm and ejaculation as 2 separate neurobiological phenomena...
February 17, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29457365/male-infertility-is-associated-with-altered-treatment-course-of-men-with-cancer
#15
O Eminaga, S Li, L C Baker, J D Brooks, M L Eisenberg
This study aims to evaluate whether cancer treatments differ in infertile men compared to men who have undergone vasectomy and age-matched controls. We analyzed subjects from the Truven Health MarketScan Claims database from 2001 to 2009. Infertile men were identified through diagnosis and treatment codes. Comparison groups included vasectomized men and an age-matched cohort who were not infertile and had not undergone vasectomy. We considered cancer types previously associated with infertility that were diagnosed after the diagnosis of infertility...
February 18, 2018: Andrology
https://www.readbyqxmd.com/read/29433012/talking-about-male-body-based-contraceptives-the-counseling-visit-and-the-feminization-of-contraception
#16
Katrina Kimport
In developed countries, women bear the primary, and sometimes exclusive, responsibility for preventing pregnancy in heterosexual sexual relations. This unequal burden is not an intrinsic fact; it is the consequence of broad social narratives and interpersonal negotiations. The contraceptive counseling visit is increasingly recognized as a site of the discursive production of normative ideas about reproduction, suggesting that clinicians themselves may contribute to the assignment of responsibility for contraceptive labor to women (i...
March 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29423834/factors-predicting-success-after-microsurgical-vasovasostomy
#17
Marco Cosentino, Maria F Peraza, Alvaro Vives, Josvany Sanchez, Daniel Moreno, Judith Perona, Gerardo Ortiz, Maria Alcoba, Eduardo Ruiz, Joaquim Sarquella
PURPOSE: To identify factors predicting success and analyze critically the status of microsurgical double-layer vasovasostomy using predictive models. METHODS: A cohort of 263 patients treated at our institution for vasectomy reversal between 1986 and 2010 was included in our study, and the literature was reviewed. Inclusion criteria were previous bilateral vasectomy and presence of at least two postoperative semen analyses; patients reporting pregnancy without a postoperative semen analysis were excluded...
April 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29352521/microdenervation-of-the-spermatic-cord-for-post-vasectomy-pain-syndrome
#18
Wei Phin Tan, Peter N Tsambarlis, Laurence A Levine
OBJECTIVE: To evaluate the outcomes of patients who underwent microdenervation of the spermatic cord (MDSC) for post-vasectomy pain syndrome (PVPS) at our institution. METHODS: A retrospective study of all patients who underwent MDSC for PVPS by a single surgeon between March 2002 and October 2016 was performed. Pain was documented using the numerical rating scale (NRS). Spermatic cord block (SCB) was performed on all patients, and success was defined as NRS score ≤1 for >4 h...
April 2018: BJU International
https://www.readbyqxmd.com/read/29305203/seminal-vesicle-abscess-an-unusual-complication-following-vasectomy
#19
Néha Sihra, Mohamed Aboelsoud, Abisola Oliyide, Andrew Counsell, Zara Gall
No abstract text is available yet for this article.
January 2, 2018: Urology
https://www.readbyqxmd.com/read/29297842/sterilization-of-hybrid-marmoset-callithrix-sp-females-an-evaluation-of-two-surgical-methods
#20
Fábio Ferreira de Queiroz, Giane Chaves Kristosch, Flávio Landim Soffiati, Mônica Jorge Luz, André Lacerda de Abreu Oliveira, Tânia Ribeiro Junqueira Borges, Carlos Ramón Ruiz Miranda, Leonardo Serafim da Silveira
Population control techniques, either permanent or reversible, are important tools for the management of wildlife in captive and natural environments. Among these, surgical sterilization provides a permanent solution to unwanted reproduction. Surgical techniques can differ in their invasiveness and in the subsequent effect on behavior and physiology. For social animals, techniques that preserve gonads, such as vasectomy for males and ligation of uterine tubes for females, may be preferred because they maintain important physiology that influences behavior...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
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