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Beibei Sun, Xiao Li, Xiaosheng Liu, Xiaoqian Ge, Qing Lu, Xihai Zhao, Jun Pu, Jianrong Xu, Huilin Zhao
BACKGROUND: Type 2 diabetes mellitus (T2DM) might aggravate the carotid plaque vulnerability, and increase the risk for ischemic stroke. Few studies reported the acute stroke subtype with carotid plaque characteristics in T2DM patients. This study aimed to investigate the association between carotid plaque characteristics and acute cerebral infarct (ACI) lesion features determined by MRI in T2DM patients. METHODS: Patients with acute cerebrovascular syndrome in internal carotid artery territory were recruited...
September 11, 2017: Cardiovascular Diabetology
Jeffrey B Schriber, Francesco A Evangelista
We introduce and analyze various approaches to compute excited electronic states using our recently developed adaptive configuration interaction (ACI) method [J.B. Schriber and F.A. Evangelista, J. Chem. Phys. \textbf{144}, 161106 (2016)]. These ACI methods aim at describing multiple electronic states with equal accuracy, including challenging cases like multi-electron, charge transfer, and near-degenerate states. We develop both state-averaged and state-specific approaches to compute excited states whose absolute energy error can be tuned by a user-specified energy error threshold, $\sigma$...
September 11, 2017: Journal of Chemical Theory and Computation
Ali Güncan, Ebru Gümüs
The Mikomya coryli (Kieffer) (Diptera: Cecidomyiidae) is widespread in Europe and the most important cecidomyiid pest of hazelnut. Within-plant distribution, susceptibility of 18 Turkish hazelnut cultivars ('Acı,' 'Allahverdi,' 'Çakıldak,' 'Cavcava,' 'Foşa,' 'İncekara,' 'Kalınkara,' 'Kan,' 'Karafindık,' 'Kargalak,' 'Kuş,' 'Mincane,' 'Palaz,' 'Sivri,' 'Tombul,' 'Uzunmusa,' 'Yassı Badem,' and 'Yuvarlak Badem'), and the phenology of larvae of this pest in hazelnut leaves and involucres were assessed in 2014 and 2015 in Giresun (Turkey)...
August 1, 2017: Environmental Entomology
Saeyoung Lee, Eun Ju Yun, Kyoung Heon Kim, Hye Yeon Kim, In Geol Choi
3,6-Anhydro-L-galactonate cycloisomerase (ACI), which is found in the marine bacterium Vibrio sp. strain EJY3, converts 3,6-anhydro-L-galactonate into 2-keto-3-deoxygalactonate. ACI is a key enzyme in the metabolic pathway of 3,6-anhydro-L-galactose (AHG). Study of AHG metabolism is important for the efficient fermentation of agar and biofuel production, because AHG is a sugar that is non-fermentable by commercial microorganisms. The aci gene from Vibrio sp. strain EJY3 was cloned, and the recombinant protein was overexpressed and crystallized in order to determine the structure and understand the function of the protein...
September 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
John G Noel, Benjamin J Ramser, Jose A Cancelas, Francis X McCormack, Jason C Gardner
Inflammation mediated impairment of erythropoiesis, plays a central role in the development of the anemia of critical illness (ACI). ACI develops despite elevation of endogenous erythropoietin (EPO), does not respond to exogenous EPO supplementation, and contributes significantly to transfusion requirements in burned patients. We have previously reported that the reduction of red blood cell mass in the bone marrow of a burn-injured ACI mouse model is G-CSF dependent. Given that elevated G-CSF levels have also been associated with lower hemoglobin levels and increased transfusion requirements in trauma victims, we postulated that G-CSF mediates post burn EPO resistance...
August 31, 2017: Experimental Hematology
Joshua J Hamilton, Sarahi L Garcia, Brittany S Brown, Ben O Oyserman, Francisco Moya-Flores, Stefan Bertilsson, Rex R Malmstrom, Katrina T Forest, Katherine D McMahon
An explosion in the number of available genome sequences obtained through metagenomics and single-cell genomics has enabled a new view of the diversity of microbial life, yet we know surprisingly little about how microbes interact with each other or their environment. In fact, the majority of microbial species remain uncultivated, while our perception of their ecological niches is based on reconstruction of their metabolic potential. In this work, we demonstrate how the "seed set framework," which computes the set of compounds that an organism must acquire from its environment (E...
July 2017: MSystems
Rei Kuwabara, Masahide Hamaguchi, Takuya Fukuda, Hiroki Sakai, Makoto Inui, Shimon Sakaguchi, Hiroo Iwata
BACKGROUND: There exists a need for a minimally invasive method of islet transplantation without immunosuppressive drugs for the treatment of type 1 diabetes. METHODS: In diabetic ACI rats, an agarose rod containing the cyclic oligopeptide SEK-1005 (agarose-SEK rod) was implanted at 2 dorsal subcutaneous sites. Then these rods were removed, and 1500 islets isolated from F344 rats were transplanted into each of the pockets. RESULTS: Ten days after implantation of agarose-SEK rods, vascularized pockets were present...
August 30, 2017: Transplantation
Robert Drozd, Karolina Rojek-Sito, Rafal Rygula
In the present study, we have investigated the effects of the traits 'optimism' and 'pessimism' on cognitive flexibility in an animal model of depression based on chronic restraint stress. For this, first, we trained and tested the rats in a series of ambiguous-cue interpretation (ACI) tests, which allowed us to classify them as 'optimistic' or 'pessimistic'. Subsequently, we re-trained and re-tested the animals in the Attentional Set Shifting Task (ASST), which allowed evaluation of the differences between 'optimists' and 'pessimists' in terms of cognitive flexibility...
August 24, 2017: Behavioural Brain Research
Ines Kovačić, Maja Fafanđel, Lorena Perić, Iris Batel
Acid DNase activity in marine organisms displays a sensitive response to pollutants. In the present study, ex situ effect of toxic seawater organic extracts (Rijeka, Vranjic, Ploče) and in situ impact of environmental factors at referent (St. Andrew) and a polluted site (ACI Rovinj) on acid DNase in the digestive gland and gills of mussels was investigated. In the digestive gland, enzyme activity was related to potential toxicity of seawater organic extracts. Seawater organic extracts showed an increase of the enzyme activity in digestive gland following exposure...
August 24, 2017: Bulletin of Environmental Contamination and Toxicology
Matthias Aurich, Gunther Olaf Hofmann, Bernd Rolauffs
PURPOSE: The aim was to analyse the biological characteristics of chondrocytes from the two biopsy sites notch vs. trochlea of human knee joints. The question was whether tissue engineering-relevant characteristics such as viability and mRNA expression profile would be comparable ex vivo and after monolayer expansion, as these are parts of routine autologous chondrocyte implantation (ACI). METHODS: Biopsies from the intercondylar notch and the lateral aspect of the trochlea from 20 patients with ICRS grades 3 and 4 cartilage defects were harvested during arthroscopy...
August 21, 2017: International Orthopaedics
Jonas Czwikla, Kathrin Jobski, Tania Schink
BACKGROUND: This cohort study examined the impact of the lengths of lookback and confirmation periods as well as the definition of confirmatory events on the number of incident cancer cases identified and age-standardized cumulative incidences (ACI) estimated in administrative data using German cancer registry data as a benchmark. METHODS: ACI per 100,000 insured persons for breast, prostate and colorectal cancer were estimated using BARMER Statutory Health Insurance claims data...
August 14, 2017: BMC Medical Research Methodology
M Berruto, P Ferrua, S Pasqualotto, F Uboldi, A Maione, D Tradati, E Usellini
INTRODUCTION: Autologous Chondrocyte Implantation (ACI) has been the first technique in reconstruction of a valid articular surface. The aim of this study was to evaluate clinical results of this technique at an average follow up of 162±27months (range 88-208) in a group of patients who underwent ACI. MATERIALS AND METHODS: 32 patients were operated between 1997 and 2007 for chondral lesions or osteochondritis dissecans of the knee. Mean size of the defect was 5...
August 4, 2017: Injury
F D Halstead, M A Webber, B A Oppenheim
OBJECTIVE: We previously reported on the ability of SurgihoneyRO (SHRO), an engineered honey, to prevent biofilm formation in vitro, but data were lacking regarding the activity against preformed biofilms. This study aims to assess whether SHRO has any antibacterial activity against mature, preformed biofilms and whether there is any evidence to support the observed clinical effectiveness when SHRO has been used anecdotally on acute and chronic wounds where biofilm is most likely present...
August 2, 2017: Journal of Wound Care
Lu Tian, Wenyu Li, Xinmei Huang, Di Tian, Jianhua Liu, Xinchao Yang, Lianrui Liu, Ruofeng Yan, Lixin Xu, Xiangrui Li, Xiaokai Song
Coccidiosis is an intestinal disorder of poultry and often caused by simultaneous infections of several Eimeria species. GAPDH is one of the immunogenic common antigens among Eimeria tenella, E. acervulina, and E. maxima identified in our previous study. The present study was performed to further evaluate its immunogenicity and protective efficacy. The genes of GAPDH cloned from E. acervulina and E. maxima were named as EaGAPDH and EmGAPDH, respectively. The immunogenicity of recombinant proteins of EaGAPDH and EmGAPDH were analyzed by Western blot...
2017: Frontiers in Microbiology
Georgia Athanasiou, George C Anastasopoulos, Eleni Tiritidou, Dimitrios Lymberopoulos
Trust is considered to be a determinant on psychologist selection which can ensure patient satisfaction. Hence, trust concept is essential to be introduced into Ubiquitous Healthcare (UH) environment oriented on patients with anxiety disorders. This is accomplished by Trust Model estimating psychologists' trustworthiness, a priory to service delivery, with the use of patient's and his/her acquaintances testimonies, i.e. Personal Interaction Experience (PIE) and Reputation (R). In this paper, Trust Model is proposed to be materialized via an Adaptable Cloud Inference System (ACIS) that performs Trust Value (TV) estimation...
July 28, 2017: IEEE Journal of Biomedical and Health Informatics
Takahiro Ogura, Brian A Mosier, Tim Bryant, Tom Minas
BACKGROUND: Treating articular cartilage defects is a demanding problem. Although several studies have reported durable and improved clinical outcomes after autologous chondrocyte implantation (ACI) over a long-term period, there is no report with over 20 years' follow-up. PURPOSE: To evaluate clinical outcomes after first-generation ACI for the treatment of knees with disabling, large single and multiple cartilage defects for which patients wished to avoid prosthetic arthroplasty, with a minimum of 20 years' follow-up...
July 1, 2017: American Journal of Sports Medicine
Zuojun Tian, Geng Liao, Shaoming Li, Yuechun Shen, Changbing Chen, Lei Liu, Yiheng Li
Since intravenous thrombolysis (IVT) is often associated with poor outcomes in hypertensive patients with severe acute cerebral infarction (ACI) due to occlusions of the internal carotid, basilar, or proximal middle cerebral artery, we evaluated whether multimodal intra-arterial treatment (IAT) might improve functional outcomes in this patient population. We retrospectively reviewed the charts of eligible patients who underwent multimodal IAT including intra-arterial thrombolysis, mechanical thrombectomy, balloon and/or stent angioplasty (IAT group) or IVT alone (IVT group)...
July 21, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Celina Faig Lima, Monica Ghislaine Oliveira Alves, Bruna Fernandes do Carmo Carvalho, Thaynara Alves de Lima, Cláudia Malheiros Coutinho-Camillo, Fernando Augusto Soares, Jaqueline Scholz, Janete Dias Almeida
In the oral cavity, genomic instability is caused by long-term exposure to carcinogens. The aim of the present study was to evaluate the relationship between smoking and DNA ploidy METHODS: Cytological material was obtained from patients participating in the Outpatient Smoking Treatment Program of the Heart Institute (INCOR-HCFMUSP), and of the Discipline of Oral Medicine (ICT-UNESP). The inclusion criteria for all groups were the absence of a history of malignant tumors, absence of clinical signs of changes in the selected area, and alcohol consumption of less than 3 units per week...
July 20, 2017: Journal of Oral Pathology & Medicine
K A Dembek, K J Timko, L M Johnson, K A Hart, B S Barr, B David, T A Burns, R E Toribio
Hypothalamic-pituitary-adrenal axis (HPAA) dysfunction has been associated with sepsis and mortality in foals. Most studies have focused on cortisol, while other steroids have not been investigated. The objectives of this study were to characterise the adrenal steroid and steroid precursor response to disease and to determine their association with the HPAA response to illness, disease severity, and mortality in hospitalised foals. All foals (n=326) were classified by two scoring systems into three categories: based on the sepsis score (septic, sick non-septic [SNS] and healthy) and the foal survival score (Group 1: 3-18%; Group 2: 38-62%; Group 3: 82-97% likelihood of survival)...
July 2017: Veterinary Journal
Saeyoung Lee, Kyoung Heon Kim, Hye-Yeon Kim, In-Geol Choi
3,6-Anydro-l-galatonate cycloisomerase (ACI) catalyzes the cycloisomerization of a 3,6-anhydro-l-galactonic acid known as a novel metabolite in agarolytic bacteria. Here, we present 3-D structures of ACI from Vibrio sp. strain EJY3 (VejACI) in native and mutant forms at 2.2 Å and 2.6 Å resolutions, respectively. The enzyme belongs to the mandelate racemase subgroup of the enolase superfamily catalyzing common β-elimination reactions by α-carbon deprotonation of substrates. The structure of VejACI revealed a notable 20s loop region in the capping domain, which can be a highly conserved structural motif in ACI homologs of agar metabolism...
September 9, 2017: Biochemical and Biophysical Research Communications
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