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https://www.readbyqxmd.com/read/29146220/autologous-chondrocyte-implantation-for-talar-osteochondral-lesions-comparison-between-5-year-follow-up-magnetic-resonance-imaging-findings-and-7-year-follow-up-clinical-results
#1
Gherardo Pagliazzi, Francesca Vannini, Milva Battaglia, Laura Ramponi, Roberto Buda
Autologous chondrocyte implantation (ACI) is an established surgical procedure that has provided satisfactory results. The aim of the present study was to correlate the clinical outcomes of a series of 20 patients treated by ACI at a 7-year follow-up examination with the magnetic resonance imaging (MRI) T2-mapping 5-year follow-up findings. We evaluated 20 patients using the American Orthopaedic Foot and Ankle Society (AOFAS) score preoperatively and the established follow-up protocol until 87.2 ± 14.5 months...
November 14, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29144055/confocal-raman-spectroscopic-imaging-for-in-vitro-monitoring-of-active-ingredient-penetration-and-distribution-in-reconstructed-human-epidermis-model
#2
Lynda Miloudi, Franck Bonnier, Ali Tfayli, Florent Yvergnaux, Hugh J Byrne, Igor Chourpa, Emilie Munnier
Topically applied Active Cosmetic Ingredients (ACI) or Active Pharmaceutical Ingredients (API) efficacy is directly related to their efficiency of penetration in the skin. In vitro Reconstructed Human Epidermis (RHE) surrogate models offer in vivo like skin samples for transdermal studies. Using Delipidol®, an ACI currently used in the cosmetics industry, the capabilities to deliver accurate distribution maps and penetration profiles of this molecule by means of Confocal Raman spectroscopic Imaging have been demonstrated...
November 16, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29125919/autologous-chondrocyte-implantation-sandwich-technique-compared-with-autologous-bone-grafting-for-deep-osteochondral-lesions-in-the-knee
#3
Tom Minas, Takahiro Ogura, Jeff Headrick, Tim Bryant
BACKGROUND: Treating symptomatic osteochondral defects is challenging, especially in young adults with deep (>8-10 mm) empty defects after osteochondritis dissecans (OCD) or collapsed condyles secondary to avascular necrosis (AVN). For this population, osteoarthritis (OA) is inevitable if articular congruence is not restored. PURPOSE: To describe the autologous chondrocyte implantation (ACI) "sandwich" technique with autologous bone grafting (ABG) and compare it with ABG alone for restoration of the osteochondral unit...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29114638/how-to-manage-a-failed-cartilage-repair-a-systematic-literature-review
#4
REVIEW
Donato Rosa, Sigismondo Luca Di Donato, Giovanni Balato, Alessio D'Addona, Francesco Smeraglia, Gaetano Correra, Gianni Di Vico
Purpose  The aims of this paper are to report the rate and risk factors for the failure of the most common cartilage repair technique, and analyze the most important factors that could influence the choice of a specific surgical treatment to revise a failed cartilage repair. Methods  A review of the literature was performed focusing on failed cartilage repair and related treatments. Two of the authors independently screened articles. Conflicts about the inclusion of a paper was resolved by further evaluation by the senior author...
June 2017: Joints
https://www.readbyqxmd.com/read/29100004/autologous-chondrocyte-implantation-in-osteoarthritic-surroundings-tnf%C3%AE-and-its-inhibition-by-adalimumab-in-a-knee-specific-bioreactor
#5
Robert Ossendorff, Sibylle Grad, Martin J Stoddart, Mauro Alini, Hagen Schmal, Norbert Südkamp, Gian M Salzmann
BACKGROUND: Autologous chondrocyte implantation (ACI) fails in up to 20% of cases. Advanced intra-articular degeneration paired with an inflammatory environment may be closely related to implantation failure. Certain cytokines have been identified to play a major role during early osteoarthritis. PURPOSE: To investigate the effects of tumor necrosis factor α (TNFα) and its potential inhibition by adalimumab on cartilage regeneration in an in vitro model of ACI...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29095597/new-type-of-2d-perovskites-with-alternating-cations-in-the-interlayer-space-c-nh2-3-ch3nh3-npbni3n-1-structure-properties-and-photovoltaic-performance
#6
Chan Myae Myae Soe, Constantinos C Stoumpos, Mikaël Kepenekian, Boubacar Traoré, Hsinhan Tsai, Wanyi Nie, Binghao Wang, Claudine Katan, Ram Seshadri, Aditya D Mohite, Jacky Even, Tobin J Marks, Mercouri G Kanatzidis
We present the new homologous series (C(NH2)3)(CH3NH3)nPbnI3n+1 (n = 1, 2, 3) of layered 2D perovskites. Structural characterization by single-crystal X-ray diffraction reveals that these compounds adopt an unprecedented structure type, which is stabilized by the alternating ordering of the guanidinium and methylammonium cations in the interlayer space (ACI). Compared to the more common Ruddlesden-Popper (RP) 2D perovskites, the ACI perovskites have a different stacking motif and adopt a higher crystal symmetry...
November 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29091069/phase-contrast-imaging-of-preclinical-portal-vein%C3%A2-embolization-with-co2-microbubbles
#7
Rongbiao Tang, Fuhua Yan, Guo Yuan Yang, Ke Min Chen
Preoperative portal vein embolization (PVE) is employed clinically to avoid postoperative liver insufficiency. Animal models are usually used to study PVE in terms of mechanisms and pathophysiological changes. PVE is formerly monitored by conventional absorption contrast imaging (ACI) with iodine contrast agent. However, the side effects induced by iodine can give rise to animal damage and death. In this study, the feasibility of using phase contrast imaging (PCI) to show PVE using homemade CO2 microbubbles in living rats has been investigated...
November 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/29083347/current-concepts-in-treatment-of-early-knee-osteoarthritis-and-osteochondral-lesions-the-role-of-biological-augmentations
#8
C Dall'Oca, M Cengarle, A Costanzo, N Giannini, A Vacchiano, B Magnan
Early knee osteoarthritis and chondral lesions are a common cause of disability in younger patients. Surgical options, such as microfractures, ACI and OAT, provide good, but not fully satisfying, outcomes. Recent advance in biological knowledge introduced two different methodological approaches of delivering growth factors and stem cells into the articular environment. Platelet-Rich Plasma and Mesenchimal Stem Cells are supposed to change the way to approach early knee osteoarthritis and chondral lesions, though their indications and limits are yet to be determined...
October 18, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29077149/effects-of-dl-3-n-butylphthalide-on-serum-vegf-and-bfgf-levels-in-acute-cerebral-infarction
#9
S-C Tang, C-J Luo, K-H Zhang, K Li, X-H Fan, L-P Ning, P Xue
OBJECTIVE: To observe the curative effect of dl-3-n-Butylphthalide (NBP) on patients with acute cerebral infarction (ACI) and its effects on levels of serum vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). PATIENTS AND METHODS: A total of 160 ACI patients treated in our hospital who met the criteria were selected and randomly divided into treatment group (n=80, including 42 males and 38 females) and control group (n=80, including 40 males and 40 females)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29054499/coupled-in-silico-platform-computational-fluid-dynamics-cfd-and-physiologically-based-pharmacokinetic-pbpk-modelling
#10
Aleksandra Vulović, Tijana Šušteršič, Sandra Cvijić, Svetlana Ibrić, Nenad Filipović
One of the critical components of the respiratory drug delivery is the manner in which the inhaled aerosol is deposited in respiratory tract compartments. Depending on formulation properties, device characteristics and breathing pattern, only a certain fraction of the dose will reach the target site in the lungs, while the rest of the drug will deposit in the inhalation device or in the mouth-throat region. The aim of this study was to link the Computational fluid dynamics (CFD) with physiologically-based pharmacokinetic (PBPK) modelling in order to predict aerolisolization of different dry powder formulations, and estimate concomitant in vivo deposition and absorption of amiloride hydrochloride...
October 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29053731/determination-of-%C3%AE-%C3%AE-and-%C3%AE%C2%BA-opioid-receptors-in-forebrain-cortex-of-rats-exposed-to-morphine-for-10-days-comparison-with-animals-after-20-days-of-morphine-withdrawal
#11
COMPARATIVE STUDY
Hana Ujcikova, Martina Hlouskova, Kristina Cechova, Katerina Stolarova, Lenka Roubalova, Petr Svoboda
BACKGROUND: Chronic exposure of mammalian organism to morphine results in adaption to persistent high opioid tone through homeostatic adjustments. Our previous results indicated that in the frontal brain cortex (FBC) of rats exposed to morphine for 10 days, such a compensatory adjustment was detected as large up-regulation of adenylylcyclases I (8-fold) and II (2.5-fold). The other isoforms of AC (III-IX) were unchanged. Importantly, the increase of ACI and ACII was reversible as it disappeared after 20 days of morphine withdrawal...
2017: PloS One
https://www.readbyqxmd.com/read/29051878/patellofemoral-articulating-osteochondral-kissing-lesion-treated-with-autologous-chondrocyte-implantation-a-case-report
#12
Taylor J Ridley, Christopher T Rud, Jeffrey A Macalena
INTRODUCTION: Autologous chondrocyte implantation (ACI) is an effective treatment for chondral defects of the knee; however, its use in kissing lesions is less well documented. CASE REPORT: A 23-year-old female with a kissing lesion of the patellofemoral compartment on magnetic resonance imaging underwent two-stage ACI to her medial patella (20 mm × 22 mm) and medial trochlea (27 mm × 18 mm). At 1-year follow-up, the patient had returned to all activities with near-complete resolution of symptoms and substantial improvement in clinical outcome scores...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29035456/circulating-mir-29b-and-mir-424-as-prognostic-markers-in-patients-with-acute-cerebral-infarction
#13
Yue-Zhan Zhang, Jun Wang, Feng Xu
BACKGROUND: Down-regulation of miR-29b and miR-424 have been observed in patients with acute cerebral infarction (ACI); however, the clinical significance of circulating miR-29b and miR-424 as prognostic markers still requires further investigation. METHODS: A total of 45 patients diagnosed with ACI and 45 healthy volunteers were enrolled in this study, and the clinical information of the patients were collected. The serum samples of the participants were collected and stored at -80°C...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29027997/microdiversification-in-genome-streamlined-ubiquitous-freshwater-actinobacteria
#14
Stefan M Neuenschwander, Rohit Ghai, Jakob Pernthaler, Michaela M Salcher
Actinobacteria of the acI lineage are the most abundant microbes in freshwater systems, but there are so far no pure living cultures of these organisms, possibly because of metabolic dependencies on other microbes. This, in turn, has hampered an in-depth assessment of the genomic basis for their success in the environment. Here we present genomes from 16 axenic cultures of acI Actinobacteria. The isolates were not only of minute cell size, but also among the most streamlined free-living microbes, with extremely small genome sizes (1...
October 13, 2017: ISME Journal
https://www.readbyqxmd.com/read/29024795/are-valved-holding-chambers-vhcs-interchangeable-an-in-vitro-evaluation-of-vhc-equivalence
#15
Sanjeeva Dissanayake, Mark Nagel, Emanuela Falaschetti, Jason Suggett
INTRODUCTION: The European Medicines Agency (EMA) requires that a specific valved holding chamber (VHC) is designated for use with a given pressurised metered dose inhaler (pMDI). No other regulatory authorities impose similar requirements, implying that VHCs are interchangeable. This in vitro study, employing EMA assessment criteria, assessed the equivalence of four anti-static VHCs (aVHCs) versus the non-conducting VHC most widely referenced in pMDI monographs, the AeroChamber Plus™ (AC+) VHC...
October 9, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28992124/impact-of-trajectories-of-abdominal-aortic-calcification-over-2-years-on-subsequent-mortality-a-10-year-longitudinal-study
#16
Hiroki Inoue, Sayaka Shimizu, Keita Watanabe, Yasuhiro Kamiyama, Hitomi Shima, Azuna Nakase, Hironori Ishida, Noriaki Kurita, Shingo Fukuma, Shunichi Fukuhara, Yukari Yamada
Background: Although both the presence and progression over time of vascular calcification have been shown to independently predict cardiovascular disease and mortality in chronic dialysis patients, the impact of the pattern of accumulation of abdominal aortic calcification on mortality has not yet been investigated. Methods: We conducted a longitudinal study at a dialysis hospital in Hokkaido, Japan from 2005 to 2014. An abdominal calcification index (ACI) was generated for 396 patients from their annual abdominal computed tomography (CT) scans...
August 25, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28979765/micrornas-in-the-development-and-neoplasia-of-the-mammary-gland
#17
REVIEW
Manoj Kumar Jena
Study on the role of microRNAs (miRs) as regulators of gene expression through posttranscriptional gene silencing is currently gaining much interest,due to their wide involvement in different physiological processes. Understanding mammary gland development, lactation, and neoplasia in relation to miRs is essential. miR expression profiling of the mammary gland from different species in various developmental stages shows their role as critical regulators of development. miRs such as miR-126, miR-150, and miR-145 have been shown to be involved in lipid metabolism during lactation...
2017: F1000Research
https://www.readbyqxmd.com/read/28975376/customized-post-operative-alignment-improves-clinical-outcome-following-medial-open-wedge-osteotomy
#18
Lisa Hohloch, Suchung Kim, Julian Mehl, Jörn Zwingmann, Matthias J Feucht, Helge Eberbach, Philipp Niemeyer, Norbert Südkamp, Gerrit Bode
PURPOSE: High tibial osteotomy (HTO) has gained more importance in the treatment of cartilage damage or osteoarthritis of the medial compartment with concurrent varus deformity. Concerning the extent of axis correction, various different views exist. The aim of this study was to evaluate the effect of the size of axis correction on functional outcome in patients undergoing a valgus HTO. METHODS: From 2005 to 2013, 156 patients with an underlying varus deformity and cartilage damages or unicompartimental osteoarthritis of the medial compartment were treated by HTO...
October 3, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28972008/differential-gene-regulation-and-tumor-inhibitory-activities-of-alpha-delta-and-gamma-tocopherols-in-estrogen-mediated-mammary-carcinogenesis
#19
Soumyasri Das Gupta, Misaal Patel, Joseph Wahler, Min Ji Bak, Brian A Wall, Mao-Jung Lee, Yong Lin, Weichung Joe Shih, Li Cai, Chung S Yang, Nanjoo Suh
Despite experimental evidence elucidating the anti-tumor activities of tocopherols, clinical trials with α-tocopherol (α-T) have failed to demonstrate its beneficial effects in cancer prevention. This study compared the chemopreventive efficacy of individual tocopherols (α-, δ-, γ-T) and a γ-T rich tocopherol mixture (γ-TmT) in the August Copenhagen Irish (ACI) rat model of estrogen-mediated mammary cancer. Female ACI rats receiving 17β-estradiol (E2) implants were administered with 0.2% α-T, δ-T, γ-T or γ-TmT for 30 weeks...
September 28, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28969551/aptamer-oligonucleotides-as-potential-therapeutics-in-hematologic-diseases
#20
Weibin Li, Meng Zhao, Kaiyu Wang, Huihui Yan, XIaopeng Lan
Aptamers are single-stranded DNA or RNA oligonucleotides generated by a novel in vitro selection technique termed Systematic Evolution of Ligands by Exponential Enrichment (SELEX). During the past two decades, various aptamer drugs have been developed and many of them have entered into clinical trials. In the present review, we focus on aptamers as potential therapeutics for hematological diseases, including anemia of chronic inflammation (ACI) and anemia of chronic disease (ACD), hemophilia, thrombotic thrombocytopenic purpura (TTP) or VWD type-2B, and sickle cell disease (SCD), in particular, those that have entered into clinical trials...
October 2, 2017: Mini Reviews in Medicinal Chemistry
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