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JOURNAL ARTICLE
Simonetta Frezza, Eloisa Tiberi, Mirta Corsello, Francesca Priolo, Francesco Cota, Piero Catenazzi, Guido Conti, Simonetta Costa, Giovanni Vento
The incidence of sensorineural hearing loss (SNHL) is still high in very low birth weight (VLBW) infants. The purpose of our study was to provide the prevalence rates of SNHL and to analyze the risk factors of hearing impairment and changes in hearing thresholds in a cohort of VLBW infants. A retrospective observational study was conducted in our neonatal intensive care unit (NICU) from 2012 to 2016. All VLBW infants included were screened by transient evoked otoacoustic emissions (TEOAEs) and diagnostic auditory brainstem response (ABR)...
December 8, 2023: Journal of Clinical Medicine
#2
JOURNAL ARTICLE
Milena Tana, Anthea Bottoni, Francesco Cota, Patrizia Papacci, Alessia Di Polito, Arianna Del Vecchio, Anna Laura Vento, Benedetta Campagnola, Sefora Celona, Laura Cricenti, Ilaria Bastoni, Chiara Tirone, Claudia Aurilia, Alessandra Lio, Angela Paladini, Stefano Nobile, Alessandro Perri, Annamaria Sbordone, Alice Esposito, Simona Fattore, Paola Emilia Ferrara, Gianpaolo Ronconi, Giovanni Vento
BACKGROUND: Tactile stimulation manoeuvres stimulate spontaneous breathing in preterm newborns. The aim of this study is to evaluate the effect of early respiratory physiotherapy on the need for mechanical ventilation during the first week of life in preterm infants with respiratory failure. METHODS: This is a monocentric, randomised controlled trial. Preterm infants (gestational age ≤ 30 weeks) not intubated in the delivery room and requiring non-invasive respiratory support at birth were eligible for the study...
October 30, 2023: Children
#3
JOURNAL ARTICLE
Vito D'Andrea, Giorgia Prontera, Giovanni Pinna, Francesco Cota, Simona Fattore, Simonetta Costa, Martina Migliorato, Giovanni Barone, Mauro Pittiruti, Giovanni Vento
OBJECTIVE: To evaluate the role of cyanoacrylate glue in reducing dislodgement of umbilical venous catheters (UVCs). STUDY DESIGN: This was a single-center, randomized, controlled, non-blinded trial. All infants requiring an UVC according to our local policy were included in the study. Infants with a UVC with a centrally located tip as verified by real-time ultrasound were eligible for the study. Primary outcome was the safety and efficacy of securement by cyanoacrylate glue plus cord-anchored suture (SG-group) vs...
May 25, 2023: Journal of Pediatrics
#4
JOURNAL ARTICLE
Vito D'Andrea, Giorgia Prontera, Francesco Cota, Rosellina Russo, Giovanni Barone, Giovanni Vento
OBJECTIVE: Epicutaneo-caval catheters (ECCs) are essential for the care of sick infants who require long-term medical and nutritional management. The aim of this study was to investigate the use of real-time ultrasound as an alternative to X-rays to reduce the incidence of primary malpositions during catheter insertion. STUDY DESIGN: Data on ECCs were retrospectively collected in a tertiary neonatal intensive care unit. Catheter were analyzed considering the tip location technique (standard chest-abdominal radiograph vs real-time ultrasound) RESULTS: A total of 248 ECCs were analyzed...
January 24, 2023: American Journal of Perinatology
#5
JOURNAL ARTICLE
Francesca Gallini, Maria Sofia Pelosi, Domenico Umberto De Rose, Maria Coppola, Simonetta Costa, Domenico Marco Romeo, Carmen Cocca, Luca Maggio, Francesco Cota, Alessandra Piersanti, Daniela Ricci, Giovanni Vento
BACKGROUND: Few studies in the literature have analyzed the long-term neurodevelopmental outcomes of the administration of a multicomponent versus a soybean-based lipid emulsion (LE) in preterm infants receiving parenteral nutrition (PN). A recent randomized controlled trial conducted in our unit provided evidence of better growth in head circumference during the hospital stay in those who received a multicomponent LE. METHODS: This is a 24 month follow-up study of preterm infants, previously enrolled in a randomized trial, who received a multicomponent LE (SMOFlipid® ) or a standard soybean-based one (Intralipid® )...
December 23, 2022: Nutrients
#6
REVIEW
Michela Chiappalone, Vinicius R Cota, Marta Carè, Mattia Di Florio, Romain Beaubois, Stefano Buccelli, Federico Barban, Martina Brofiga, Alberto Averna, Francesco Bonacini, David J Guggenmos, Yannick Bornat, Paolo Massobrio, Paolo Bonifazi, Timothée Levi
Neuroprostheses are neuroengineering devices that have an interface with the nervous system and supplement or substitute functionality in people with disabilities. In the collective imagination, neuroprostheses are mostly used to restore sensory or motor capabilities, but in recent years, new devices directly acting at the brain level have been proposed. In order to design the next-generation of neuroprosthetic devices for brain repair, we foresee the increasing exploitation of closed-loop systems enabled with neuromorphic elements due to their intrinsic energy efficiency, their capability to perform real-time data processing, and of mimicking neurobiological computation for an improved synergy between the technological and biological counterparts...
November 19, 2022: Brain Sciences
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JOURNAL ARTICLE
Francesca Gallini, Domenico Umberto De Rose, Maria Coppola, Maria Sofia Pelosi, Francesco Cota, Anthea Bottoni, Daniela Ricci, Domenico Marco Romeo, Teresa Spanu, Luca Maggio, Eugenio Mercuri, Giovanni Vento
INTRODUCTION: Ureaplasma ( U .) and Mycoplasma ( M .) species have been related to pregnancy complications (including preterm birth) and worse neonatal outcomes. The aim of our work is to evaluate neurodevelopmental outcomes in preterm infants born to mothers with Ureaplasma / Mycoplasma colonization during pregnancy. METHODS: Preterm infants with gestational age (GA) of ≤ 30 weeks were included in a retrospective follow-up study. To evaluate the effects of maternal vaginal colonization, we divided preterm infants into two groups: exposed and unexposed infants...
2022: Frontiers in Pediatrics
#8
JOURNAL ARTICLE
Alessia Di Polito, Arianna Del Vecchio, Milena Tana, Patrizia Papacci, Anna Laura Vento, Benedetta Campagnola, Sefora Celona, Laura Cricenti, Ilaria Bastoni, Chiara Tirone, Alessandra Lio, Claudia Aurilia, Anthea Bottoni, Angela Paladini, Francesco Cota, Paola Emilia Ferrara, Gianpaolo Ronconi, Giovanni Vento
BACKGROUND: Tactile maneuvers stimulating spontaneous respiratory activity in preterm infants are recommended since birth, but data on how and how often these maneuvers are applied in clinical practice are unknown. In the last years, most preterm newborns with respiratory failure are preferentially managed with non-invasive respiratory support and by stimulating spontaneous respiratory activity from the delivery room and in neonatal intensive care unit (NICU), in order to avoid the risks of intubation and prolonged mechanical ventilation...
July 26, 2021: Trials
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JOURNAL ARTICLE
Domenico Umberto De Rose, Francesco Cota, Francesca Gallini, Anthea Bottoni, Giovanna Carmela Fabrizio, Daniela Ricci, Domenico Marco Romeo, Eugenio Mercuri, Giovanni Vento, Luca Maggio
AIM: Extra-uterine Growth Restriction (EUGR) is common among preterm infants. Two types of EUGR definitions are still now available: cross-sectional definitions and longitudinal ones. In a cohort of very preterm infants, we aimed to evaluate which definition could better predict neurodevelopmental outcomes at 2 years of corrected age. We used Italian Neonatal Study Charts (INeS) growth charts and INTERGROWTH-21st (IG-21) standard charts and compared results. METHOD: We restrospectively collected data from clinical charts of 324 preterm newborns with a gestational age ≤30 weeks born from 2012 to 2017...
July 2021: European Journal of Paediatric Neurology: EJPN
#10
RANDOMIZED CONTROLLED TRIAL
Alessandro Perri, Eloisa Tiberi, Lucia Giordano, Annamaria Sbordone, Maria Letizia Patti, Rossella Iannotta, Teresa Pianini, Francesco Cota, Luca Maggio, Giovanni Vento
OBJECTIVE: To evaluate the efficacy of a strict glycaemic control protocol using a continuous glucose monitoring (CGM) in infants at high risk of dysglycaemia with the aim of reducing the number of dysglycaemic episodes. DESIGN: Randomised controlled trial. SETTING: Neonatal intensive care unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome. PATIENTS: All infants <1500 g fed on parental nutrition (PN) since birth were eligible...
January 2022: Archives of Disease in Childhood. Fetal and Neonatal Edition
#11
REVIEW
Giuseppe Sangiorgi, Alberto Cereda, Daniela Benedetto, Michela Bonanni, Gaetano Chiricolo, Linda Cota, Eugenio Martuscelli, Francesco Greco
Erectile dysfunction (ED) has been defined as the inability to attain or maintain penile erection sufficient for successful sexual intercourse. ED carries a notable influence on life quality, with significant implications for family and social relationships. Because atherosclerosis of penile arteries represents one of the most frequent ED causes, patients presenting with it should always be investigated for potential coexistent coronary or peripheral disease. Up to 75% of ED patients have a stenosis of the iliac-pudendal-penile arteries, supplying the male genital organ's perfusion...
April 16, 2021: Biomedicines
#12
JOURNAL ARTICLE
Domenico M Romeo, Frances M Cowan, Leena Haataja, Daniela Ricci, Elisa Pede, Francesca Gallini, Francesco Cota, Claudia Brogna, Giovanni Vento, Mario G Romeo, Eugenio Mercuri
AIM: We explored the ability of the Hammersmith Infant Neurological Examination (HINE) to identify typical and delayed cognitive performance in a large population of infants born preterm, both with and without cerebral palsy (CP). METHOD: We conducted a retrospective study of infants born preterm who had repeated HINEs between 3 and 12 months corrected age. At 2 years, cognition was assessed using the Mental Development Index (MDI; from the Bayley Scales of Infant Development, Second Edition) and the presence and severity of CP was determined...
August 2021: Developmental Medicine and Child Neurology
#13
JOURNAL ARTICLE
Francesca Gallini, Maria Coppola, Domenico Umberto De Rose, Luca Maggio, Roberta Arena, Valerio Romano, Francesco Cota, Daniela Ricci, Domenico Marco Romeo, Eugenio Maria Mercuri, Giovanni Vento
OBJECTIVE: Bronchopulmonary dysplasia is a chronic respiratory disease that still affects preterm neonates; its association with neurodevelopmental (ND) impairment is already known. Different studies investigated neurodevelopmental outcomes in infants with BPD, often using the old dichotomous definition (BPD vs Non-BPD). This retrospective study aims to evaluate the role of different BPD severity grades on ND outcomes at 24 months of corrected age (CA). METHODS: All preterm infants born between 2011 and 2015 in the study hospital with a gestational age (GA) ≤ 30 weeks and discharged from our NICU were included and were divided in infants with and without BPD...
January 2021: Early Human Development
#14
JOURNAL ARTICLE
Valeria Cammalleri, Saverio Muscoli, Daniela Benedetto, Giuseppe Stifano, Massimiliano Macrini, Alessio Di Landro, Marco Di Luozzo, Massimo Marchei, Enrica Giuliana Mariano, Linda Cota, Domenico Sergi, Andrea Bezzeccheri, Michela Bonanni, Martino Baluci, Pasquale De Vico, Francesco Romeo
Background After the coronavirus disease 2019 outbreak, social isolation measures were introduced to contain infection. Although there is currently a slowing down of the infection, a reduction of hospitalizations, especially for myocardial infarction, was observed. The aim of our study is to evaluate the impact of the infectious disease on ST-segment-elevation myocardial infarction (STEMI) care during the coronavirus disease 2019 pandemic, through the analysis of recent cases of patients who underwent percutaneous coronary intervention...
October 20, 2020: Journal of the American Heart Association
#15
RANDOMIZED CONTROLLED TRIAL
Giovanni Vento, Maria Luisa Ventura, Roberta Pastorino, Anton H van Kaam, Virgilio Carnielli, Filip Cools, Carlo Dani, Fabio Mosca, Graeme Polglase, Paolo Tagliabue, Luca Boni, Francesco Cota, Milena Tana, Chiara Tirone, Claudia Aurilia, Alessandra Lio, Simonetta Costa, Vito D'Andrea, Mariella Lucente, Gabriella Nigro, Lucio Giordano, Vincenzina Roma, Paolo E Villani, Francesca P Fusco, Valeria Fasolato, Maria Rosa Colnaghi, Piero G Matassa, Valentina Vendettuoli, Chiara Poggi, Antonio Del Vecchio, Flavia Petrillo, Pasqua Betta, Carmine Mattia, Giampaolo Garani, Agostina Solinas, Eloisa Gitto, Vincenzo Salvo, Giancarlo Gargano, Eleonora Balestri, Fabrizio Sandri, Giovanna Mescoli, Stefano Martinelli, Laura Ilardi, Elena Ciarmoli, Sandra Di Fabio, Eugenia Maranella, Carolina Grassia, Gaetano Ausanio, Vincenzo Rossi, Angela Motta, Lucia G Tina, Kim Maiolo, Stefano Nobile, Hubert Messner, Alex Staffler, Federica Ferrero, Ilaria Stasi, Luisa Pieragostini, Isabella Mondello, Cristina Haass, Chiara Consigli, Stefania Vedovato, Alessandra Grison, Gianfranco Maffei, Giuseppe Presta, Roberto Perniola, Marcello Vitaliti, Maria P Re, Mario De Curtis, Viviana Cardilli, Paola Lago, Francesca Tormena, Luigi Orfeo, Camilla Gizzi, Luca Massenzi, Diego Gazzolo, Maria Chiara M Strozzi, Roberto Bottino, Federica Pontiggia, Alberto Berardi, Isotta Guidotti, Caterina Cacace, Valerio Meli, Lorenzo Quartulli, Antonio Scorrano, Alessandra Casati, Lidia Grappone, J Jane Pillow
BACKGROUND: The importance of lung recruitment before surfactant administration has been shown in animal studies. Well designed trials in preterm infants are absent. We aimed to examine whether the application of a recruitment manoeuvre just before surfactant administration, followed by rapid extubation (intubate-recruit-surfactant-extubate [IN-REC-SUR-E]), decreased the need for mechanical ventilation during the first 72 h of life compared with no recruitment manoeuvre (ie, intubate-surfactant-extubate [IN-SUR-E])...
February 2021: Lancet Respiratory Medicine
#16
JOURNAL ARTICLE
Danilo Buonsenso, Antonietta Curatola, Ilaria Lazzareschi, Giuseppina Panza, Rosa Morello, Raffaella Marrocco, Piero Valentini, Francesco Cota, Claudia Rendeli
AIMS: Developmental dysplasia of the hip is an important cause of disability in children and young adult and it also has a significant socio-economic impact in our society. The main objective of our study is to evaluate, in our hospital, the effectiveness of a universal ultrasound screening protocol and to assess the general knowledge about the theme of pediatricians and neonatologists. METHODS: Retrospective study of infants born from January 2016 to April 2019, evaluated with hip ultrasound (Graf method)...
December 2021: Journal of Ultrasound
#17
JOURNAL ARTICLE
Francesco Cota, Simonetta Costa, Carmen Giannantonio, Velia Purcaro, Piero Catenazzi, Giovanni Vento
BACKGROUND: Retinopathy of prematurity (ROP) is a multifactorial retinal disorder characterized by an abnormal vascular development of the retina of the preterm infants. Carotenoids are natural pigments that are synthesized by all plants and some microorganisms where they play a role in photoprotection and coloration. Lutein and zeaxanthin (L/Z) are two carotenoids identified as the major components of the macular pigment. Recently it has been suggested that lutein and its isomer zeaxanthin may act as antioxidant agents and that they may prevent ROP...
January 2022: Journal of Maternal-fetal & Neonatal Medicine
#18
JOURNAL ARTICLE
Domenico M Romeo, Giuseppina Leo, Leonardo Lapenta, Daniela Leone, Ida Turrini, Claudia Brogna, Francesca Gallini, Francesco Cota, Giovanni Vento, Eugenio Mercuri
OBJECTIVES: (i) to assess the presence of sleep disorders in a population of very preterm children (ie, with a gestational age [GA] ≤ 31 weeks) of preschool age with no history of neurological disabilities using a questionnaire standardized for this age group and (ii) to identify possible differences in a control group of term-born children. METHODS: A total of 146 low-risk preterm children (mean gestational age 28 weeks; range: 25-30), were assessed at a preschool age (mean age 3...
May 27, 2019: Sleep Medicine
#19
REVIEW
Francesco Maria Solivetti, Flora Desiderio, Fulvia Elia, Antonino Guerrisi, Carlo Cota, Aldo Morrone
Sebaceous cysts are benign enveloped nodules resulting from an obstruction of a hair follicle. Although they are very common, differential diagnosis is not obvious and may include many diseases. Ultrasound examination with high frequency probes, in the hands of a skilled operator, is the gold standard for noninvasive evaluation of these diseases. The aim of our study was to describe sonographic patterns found in our experience with high frequency probes. We decided to reevaluate the sonographic appearance of the last 100 patients with sebaceous cysts that were under our observation through conducting a retrospective study...
December 2019: International Journal of Dermatology
#20
RANDOMIZED CONTROLLED TRIAL
Simonetta Costa, Luca Maggio, Giovanni Alighieri, Giovanni Barone, Francesco Cota, Giovanni Vento
BACKGROUND: Human milk (HM) is the best feeding for premature infants. When own mother's milk (OMM) is insufficient or unavailable, pasteurized donor human milk (PDHM) and preterm formula (PF) are the alternative nutritional sources, but the benefits of donor milk over formula are not defined. This study aimed to assess whether, in the absence of OMM, the PF could guarantee a feeding tolerance not inferior to that seen with the use of PDHM during the first two weeks of life of very preterm infants...
August 16, 2018: Italian Journal of Pediatrics
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