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Wheeze infants

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https://www.readbyqxmd.com/read/29131887/effect-of-an-intervention-to-promote-breastfeeding-on-asthma-lung-function-and-atopic-eczema-at-age-16-years-follow-up-of-the-probit-randomized-trial
#1
Carsten Flohr, A John Henderson, Michael S Kramer, Rita Patel, Jennifer Thompson, Sheryl L Rifas-Shiman, Seungmi Yang, Konstantin Vilchuck, Natalia Bogdanovich, Mikhail Hameza, Richard M Martin, Emily Oken
Importance: Atopic diseases, including asthma and atopic eczema, are the most common chronic conditions of childhood. Objective: To investigate whether an intervention to promote prolonged and exclusive breastfeeding protects against asthma, atopic eczema, and low lung function in adolescence. Design, Setting, and Participants: Follow-up of the Promotion of Breastfeeding Intervention Trial (PROBIT), a cluster randomized trial in 30 Belarusian maternity hospitals and affiliated polyclinics; recruitment of 17 046 healthy term infants took place from June 15, 1996, to December 31, 1997...
November 13, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29106950/prenatal-exposure-to-perfluoralkyl-substances-pfass-associated-with-respiratory-tract-infections-but-not-allergy-and-asthma-related-health-outcomes-in-childhood
#2
A Impinen, U C Nygaard, K C Lødrup Carlsen, P Mowinckel, K H Carlsen, L S Haug, B Granum
BACKGROUND: Prenatal exposure to perfluoralkyl substances (PFASs) has been reported to be associated with immunosuppression in early childhood, but with contradictory findings related to atopic and lung diseases. AIM: We aimed to determine if prenatal exposure to PFASs is associated with asthma or other allergic diseases or respiratory tract infections in childhood. METHODS: Nineteen PFASs were measured in cord blood available from 641 infants in the Environment and Childhood Asthma (ECA) prospective birth cohort study...
October 26, 2017: Environmental Research
https://www.readbyqxmd.com/read/29090035/congenital-lobar-emphysema-in-infants
#3
Ioana Badiu, Anca Hiriscau, Iulia Lupan, Gabriel Samasca
Congenital lobar emphysema in infants is a disorder that is detected most often in newborns or young infants. We report here the case of a 4-month-old infant who at two months suddenly presented upper respiratory infections, treated symptomatically, but evolution showed shortness of breath, wheezing, weight deficit. Thoracic ultrasound revealed left upper lobe hyperinflation causing mediastinal displacement to the right, a slightly reduced blood supply at this level, and a lobar emphysema appearance. Bronchoscopy evidenced a thickening in the left bronchial tree, due to left upper lobe emphysema...
June 2017: Mædica
https://www.readbyqxmd.com/read/29047178/the-effect-of-montelukast-on-early-life-wheezing-a-randomized-double-blinded-placebo-controlled-study
#4
Ozlem Keskin, Ebru Arik Yilmaz, Christine Motzkus, Cansin Sackesen, Craig M Lilly, Omer Kalayci
BACKGROUND: Cysteinyl-leukotrienes are increased in the airways of infants with virus-associated wheezing. We aimed to determine the effects of a cysteinyl-leukotriene-1 receptor antagonist on symptoms during an early-life wheezing illness and to investigate the factors that affect the response to this drug. METHOD: This placebo-controlled double-blinded randomized controlled trial recruited children aged 3-36 months with wheezing illness and randomized to active drug or placebo for 56 days...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047087/effects-of-hyperoxia-on-the-developing-airway-and-pulmonary-vasculature
#5
Christina M Pabelick, Michael A Thompson, Rodney D Britt
Although it is necessary and part of standard practice, supplemental oxygen (40-90% O2) or hyperoxia is a significant contributing factor to development of bronchopulmonary dysplasia, persistent pulmonary hypertension, recurrent wheezing, and asthma in preterm infants. This chapter discusses hyperoxia and the role of redox signaling in the context of neonatal lung growth and disease. Here, we discuss how hyperoxia promotes dysfunction in the airway and the known redox-mediated mechanisms that are important for postnatal vascular and alveolar development...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29042873/comparison-of-cytokine-expression-profiles-in-infants-with-a-rhinovirus-induced-lower-respiratory-tract-infection-with-or-without-wheezing-a-comparison-with-respiratory-syncytial-virus
#6
Da Eun Roh, Sook-Hyun Park, Hee Joung Choi, Yeo Hyang Kim
PURPOSE: The aim of this study was to evaluate whether infants with rhinovirus (RV) infection-induced wheezing and those with respiratory syncytial virus (RSV) infection-induced wheezing have different cytokine profiles in the acute stage. METHODS: Of the infants with lower respiratory tract infection (LRTI) between September 2011 and May 2012, 88 were confirmed using reverse transcription polymerase chain reaction and hospitalized. Systemic interferon-gamma (IFN-γ), interleukin (IL)-2, IL-12, IL-4, IL-5, IL-13, and Treg-type cytokine (IL-10) responses were examined with multiplex assay using acute phase serum samples...
September 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29042485/maternal-stress-during-pregnancy-and-allergic-diseases-in-children-during-the-first-year-of-life
#7
Katarzyna Smejda, Kinga Polanska, Dorota Merecz-Kot, Anna Krol, Wojciech Hanke, Joanna Jerzynska, Wlodzimierz Stelmach, Paweł Majak, Iwona Stelmach
BACKGROUND: Many recent studies indicate that prenatal maternal distress increases the risk of allergic diseases in children. The mechanisms that favor it are still unclear. OBJECTIVES: We aimed to assess the association between exposure to different kinds of prenatal stress and the occurrence of atopic dermatitis, food allergy, wheezing, and recurrent respiratory tract infections in children. METHODS: The study population consisted of 370 mother-child pairs from a Polish Mother and Child Cohort (REPRO_PL)...
October 17, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29041909/cost-utility-analysis-of-palivizumab-for-respiratory-syncytial-virus-infection-prophylaxis-in-preterm-infants-update-based-on-the-clinical-evidence-in-spain
#8
M Sanchez-Luna, R Burgos-Pol, I Oyagüez, J Figueras-Aloy, M Sánchez-Solís, F Martinón-Torres, X Carbonell-Estrany
BACKGROUND: This study aimed at estimating the efficiency of palivizumab in the prevention of Respiratory Syncytial Virus (RSV) infection and its sequelae in preterm infants (32(day 1)-35(day 0)weeks of gestational age -wGA-) in Spain. METHODS: A decision-tree model was developed to compare health benefits (Quality Adjusted Life Years-QALYs) and costs of palivizumab versus a non-prophylaxis strategy over 6 years. A hypothetical cohort of 1,000 preterm infants, 32(day 1)-35(day 0) wGA (4...
October 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29035013/prebiotics-for-the-prevention-of-allergies-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
C Cuello-Garcia, A Fiocchi, R Pawankar, J J Yepes-Nuñez, G P Morgano, Y Zhang, A Agarwal, S Gandhi, L Terracciano, H J Schünemann, J L Brozek
BACKGROUND: Prevalence of allergic diseases in infants is approximately 10% reaching 20 to 30% in those with an allergic first-degree relative. Prebiotics are selectively fermented food ingredients that allow specific changes in composition/activity of the gastrointestinal microflora. They modulate immune responses, and their supplementation has been proposed as an intervention to prevent allergies. OBJECTIVE: To assess in pregnant women, breastfeeding mothers, and infants (populations) the effect of supplementing prebiotics (intervention) versus no prebiotics (comparison) on the development of allergic diseases and to inform the World Allergy Organization guidelines...
November 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28993360/pertussis-manifesting-as-recurrent-cough-and-wheezing-in-an-incompletely-vaccinated-8-month-old-infant
#10
Dimitri Poddighe, Marco Giuseppe Nedbal, Nunzia Mastricci, Paola Bruni
Pertussis is an acute respiratory illness caused by Bordetella pertussis, showing a re-emergence in developed countries. However, it is probably under-recognised and, as a consequence, its burden is underestimated. Here, we report the clinical case of an infant diagnosed with pertussis, despite a regular schedule of vaccination, thanks to a careful clinical evaluation, including personal and family history. In addition to pointing the attention on a precocious diagnosis of atypical cases of pertussis, this case report further raised the issue of modifying and/or implementing the immunisation strategy, considering the ongoing changes of social (eg, immigration) and sanitary (eg, vaccine coverage) background in Italy and all over the Europe...
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28949070/long-chain-polyunsaturated-fatty-acids-in-infant-formula-and-cardiovascular-markers-in-childhood
#11
Linda P M Pluymen, Geertje W Dalmeijer, Henriëtte A Smit, Cuno S P M Uiterwaal, Cornelis K van der Ent, Lenie van Rossem
To investigate whether children who consumed infant formula supplemented with long-chain polyunsaturated fatty acids (LCPUFAs) had a more favourable cardiovascular profile than children who consumed formula without these fatty acids, we used the Wheezing Illnesses Study Leidsche Rijn, a birth cohort that included 2,468 newborns between 2001 and 2014. Data on infant feeding were obtained by questionnaires. At age 5, blood pressure, carotid intima-media thickness (CIMT), and carotid distension were measured. We used multivariable linear regression analysis to compare levels of cardiovascular markers in formula-fed children born before and after the LCPUFA supplementation...
September 26, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28899531/sleep-disorders-and-allergic-diseases-in-chinese-toddlers
#12
Xu Wang, Xiang Gao, Qian Yang, Xia Wang, Shenghui Li, Fan Jiang, Jun Zhang, Fengxiu Ouyang
OBJECTIVE: Optimal sleep is important for child growth, development, and immune function. We aimed to explore whether sleep disorders were associated with the risk of allergic diseases in Chinese toddlers. METHODS: This study included 566 children (aged 23.9 ± 0.7 months; 51.1% boys) in Shanghai, China. Sleep parameters (total sleep time, sleep onset latency, nocturnal awaking and snoring) were assessed by an expanded version of the Brief Infant Sleep Questionnaire (BISQ-expanded)...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28895039/wheezing-in-infancy-an-overview-of-recent-literature
#13
REVIEW
Christine Muglia, John Oppenheimer
PURPOSE OF REVIEW: Wheezing in infancy is a common presentation with many potential causes. In writing this review, we sought to summarize the newest recommendations and testing available for the more common etiologies of wheezing. RECENT FINDINGS: Regarding the diagnosis of asthma, the modified asthma predictive index has recently been established as a useful predictive tool. Non-breath held multidetector CT with 3D volume rendering airway images is also a newer helpful diagnostic tool for tracheomalacia due to ease of use and its 100% positive predictive value...
September 11, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28831038/caesarean-section-is-associated-with-reduced-perinatal-cytokine-response-increased-risk-of-bacterial-colonization-in-the-airway-and-infantile-wheezing
#14
Sui-Ling Liao, Ming-Han Tsai, Tsung-Chieh Yao, Man-Chin Hua, Kuo-Wei Yeh, Chih-Yung Chiu, Kuan-Wen Su, Shih-Yin Huang, Chuan-Chi Kao, Shen-Hao Lai, Jing-Long Huang
The relationship between cesarean section (CS) and allergic disorders such as asthma and wheezing has been inconsistent, and the mechanisms for their connection remained largely unknown. We aimed to investigate whether CS is associated with infantile wheeze and to explore the connection between CS and several risk factors known to correlate with allergy development. Mononuclear cells were isolated from cord blood and assessed for cytokine responses by ELISA. Bacteria from nasopharyngeal specimens were identified with traditional culture methods...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28822439/-multisystemic-smooth-muscle-dysfunction-syndrome-in-children-a-case-report-and-literature-review
#15
Y L Zhou, Y Y Zhang, B L Cheng, D Xu, L F Tang, Z M Chen
Objective: To analyze the clinical characteristics and diagnosis of multisystemic smooth muscle dysfunction syndrome(MSMDS). Method: Clinical data of a case diagnosed as MSMDS and hospitalized in our hospital in July 2016 was retrospectively analyzed. Literature search was performed at databases of PubMed, Wanfang, China National Knowledge Infrastructure and VIP with the key words "multisystemic smooth muscle dysfunction syndrome" "ACTA2" . The literature retrieval was confined from January 1980 to November 2016...
August 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28816002/maternal-body-mass-index-relation-with-infant-respiratory-symptoms-and-infections
#16
Ashley Rajappan, Anna Pearce, Hazel M Inskip, Janis Baird, Sarah R Crozier, Cyrus Cooper, Keith M Godfrey, Graham Roberts, Jane S A Lucas, Katharine C Pike
BACKGROUND: Maternal obesity is increasingly prevalent in many westernized countries. Many studies report associations between maternal obesity and childhood wheeze or asthma but few have considered maternal obesity in relation to respiratory infections or symptoms other than wheeze during infancy. This study assesses the relationship between maternal BMI and reported wheeze, cough and respiratory infections during the first year of life. METHODS: In 2799 mother-child pairs, we examined the relations between maternal pre-pregnancy BMI and pregnancy weight gain and reported offspring wheeze, prolonged cough, lower respiratory tract infection, croup, and ear infection before age 1 year, along with reported diarrhea or vomiting...
October 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28799175/low-age-low-birthweight-and-congenital-heart-disease-are-risk-factors-for-intensive-care-in-infants-with-bronchiolitis
#17
Minna Mecklin, Paula Heikkilä, Matti Korppi
AIM: This study evaluated the incidence and risk factors for intensive care and respiratory support in infant bronchiolitis. METHODS: This retrospective descriptive case-control study focused on 105 patients treated in the paediatric intensive care unit (PICU) and 210 controls treated in the emergency department or on the paediatric ward in Tampere University Hospital in Finland between 2000 and 2015. Statistically significant risk factors in nonadjusted analyses were included in the adjusted logistic regression...
August 11, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28757230/vitamin-d-high-sensitivity-c-reactive-protein-and-airway-hyperresponsiveness-in-infants-with-recurrent-respiratory-symptoms
#18
Anette M Määttä, Anne Kotaniemi-Syrjänen, Kristiina Malmström, L Pekka Malmberg, Jouko Sundvall, Anna S Pelkonen, Mika J Mäkelä
BACKGROUND: Vitamin D insufficiency might be associated with biased T-cell responses resulting in inflammatory conditions such as atopy and asthma. Little is known about the role of vitamin D in low-grade systemic inflammation and airway hyperresponsiveness (AHR) in young children. OBJECTIVE: To evaluate whether vitamin D insufficiency and increased serum high-sensitivity C-reactive protein (hs-CRP) are linked to AHR in symptomatic infants. METHODS: Seventy-nine infants with recurrent or persistent lower respiratory tract symptoms underwent comprehensive lung function testing and a bronchial methacholine challenge test...
September 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28754005/can-early-omega-3-fatty-acid-exposure-reduce-risk-of-childhood-allergic-disease
#19
REVIEW
Elizabeth A Miles, Philip C Calder
A causal link between increased intake of omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and increased incidence of allergic disease has been suggested. This is supported by biologically plausible mechanisms, related to the roles of eicosanoid mediators produced from the n-6 PUFA arachidonic acid. Fish and fish oils are sources of long chain omega-3 (n-3) PUFAs. These fatty acids act to oppose the actions of n-6 PUFAs particularly with regard to eicosanoid synthesis. Thus, n-3 PUFAs may protect against allergic sensitisation and allergic manifestations...
July 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28695368/an-interaction-of-lps-and-rsv-infection-in-augmenting-the-ahr-and-airway-inflammation-in-mice
#20
Na Zhou, Wei Li, Luo Ren, Xiaohong Xie, Enmei Liu
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection (LRTI) in children under 5 years of age, especially infants with severe bronchiolitis. Our preliminary clinical experiments showed that bacterial colonization was commonly observed in children with virus-induced wheezing, particularly in those with recurrent wheezing, suggesting that bacterial colonization with an accompanying viral infection may contribute to disease severity. In most cases, RSV-infected infants were colonized with pathogenic bacteria (mainly Gram-negative bacteria)...
July 10, 2017: Inflammation
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