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https://www.readbyqxmd.com/read/29676392/integrated-genomic-analyses-of-de-novo-pathways-underlying-atypical-meningiomas
#1
Akdes Serin Harmancı, Mark W Youngblood, Victoria E Clark, Süleyman Coşkun, Octavian Henegariu, Daniel Duran, E Zeynep Erson-Omay, Leon D Kaulen, Tong Ihn Lee, Brian J Abraham, Matthias Simon, Boris Krischek, Marco Timmer, Roland Goldbrunner, S Bülent Omay, Jacob Baranoski, Burçin Baran, Geneive Carrión-Grant, Hanwen Bai, Ketu Mishra-Gorur, Johannes Schramm, Jennifer Moliterno, Alexander O Vortmeyer, Kaya Bilgüvar, Katsuhito Yasuno, Richard A Young, Murat Günel
This corrects the article DOI: 10.1038/ncomms14433.
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29676340/progesterone-receptor-expression-and-ki-67-labelling-index-of-meningiomas-in-the-lagos-university-teaching-hospital
#2
Nzechukwu Zimudo Ikeri, Charles Chidozie Anunobi, Olufemi B Bankole
Background: Meningioma in Nigeria has been poorly studied. Its location within the intracranial cavity is associated with significant morbidity and mortality. Even when completely excised, it has a tendency to recur and this is associated with repeat operations and shortened survival. The World Health Organization (WHO) grade, progesterone receptor (PR) expression and Ki-67 index are predictive for recurrence and are, therefore, useful for individualised management. The aim of this study was therefore to determine the PR expression and Ki-67 index of meningiomas received in our institution...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29675951/genomic-profiling-of-anaplastic-meningioma-identifies-recurrent-genetic-alterations-with-relevance-to-lower-grade-meningioma
#3
Patrick J Cimino, Rebecca A Yoda, Hans-Georg Wirsching, Joshua I Warrick, Michael O Dorschner, Manuel Ferriera
Meningiomas are the most common primary intracranial tumor in adults [1]. The majority of meningiomas are histologically and clinically benign and can be cured by gross total surgical resection [2]. Current histopathology-based grading does not account for a subset of meningiomas with benign histology, but nonetheless aggressive clinical behavior and a need for additional treatment [3]. This article is protected by copyright. All rights reserved.
April 19, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29675718/ultrasound-guided-brain-surgery-echographic-visibility-of-different-pathologies-and-surgical-applications-in-neurosurgical-routine
#4
Domenico Policicchio, Artan Doda, Enrico Sgaramella, Stefano Ticca, Filippo Veneziani Santonio, Riccardo Boccaletti
BACKGROUND: The use of intraoperative ultrasound (iUS) has increased in the last 15 years becoming a standard tool in many neurosurgical centers. Our aim was to assess the utility of routine use of iUS during various types of intracranial surgery. We reviewed our series to assess ultrasound visibility of different pathologies and iUS applications during the course of surgery. MATERIALS AND METHODS: This is a retrospective review of 162 patients who underwent intracranial surgery with assistance of the iUS guidance system (SonoWand)...
April 19, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29672768/microsurgical-resection-of-a-meningioma-at-the-entrance-of-dorello-s-canal-causing-vi-cranial-nerve-compression-2-dimensional-operative-video
#5
Abdulrahman Alturki, Alejandro Enriquez-Marulanda, Raghav Gupta, Ajith J Thomas, Christopher S Ogilvy
We describe the case of a 73-yr-old female patient with a 2-yr history of diplopia that has progressively become worse. Physical examination revealed a right VI cranial nerve (CN) palsy. Magnetic resonance imaging and angiography showed a dolichoectatic basilar artery near the VI CN. A suboccipital craniectomy was performed, initially with the intention to perform a microvascular decompression; however, a red mass was encountered at the entrance of the right Dorello's canal that was compressing the VI CN. Complete resection of the lesion was done and decompression of the nerve was accomplished...
April 17, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29671572/aggregation-induced-emission-probe-for-light-up-and-in-situ-detection-of-calcium-ions-at-high-concentration
#6
Meng Gao, Yunxia Li, Xiaohui Chen, Shiwu Li, Li Ren, Ben Zhong Tang
The fluorescent probe for the detection of calcium ions is an indispensable tool in the biomedical field. The millimolar order of Ca(II) ions is associated with many physiological processes and diseases, such as hypercalcemia, soft tissue calcification, and bone microcracks. However, the conventional fluorescent probes are only suitable for imaging Ca(II) ions in the nanomolar to micromolar range, which can be because of their high affinities toward Ca(II) ions and aggregation-caused quenching drawbacks. To tackle this challenge, we herein develop an aggregation-induced emission (AIE) probe SA-4CO2 Na for selective and light-up detection of Ca(II) ions in the millimolar range (0...
April 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29671247/histopathological-features-to-define-atypical-meningioma-what-does-really-matter-for-prognosis
#7
Valeria Barresi, Simona Lionti, Samuel Caliri, Maria Caffo
Atypical meningiomas are diagnosed in the presence of: (1) three or more of the following minor atypical criteria: increased cellularity, small cells with a high nuclear/cytoplasmic ratio, prominent nucleoli, sheeting, and foci of spontaneous or geographic necrosis; (2) mitotic count ≥ 4 mitoses per 10 HPF (high mitotic index); (3) brain invasion. The 5-year disease-free survival (DFS) is around 50%. Due to their heterogeneous behavior, the post-surgical treatment of atypical meningiomas is controversial...
April 18, 2018: Brain Tumor Pathology
https://www.readbyqxmd.com/read/29669134/giant-olfactory-groove-meningioma-2-staged-approach-2-dimensional-operative-video
#8
Alexandre B Todeschini, Mostafa Shahein, Alaa S Montaser, Douglas Hardesty, Bradley A Otto, Ricardo L Carrau, Daniel M Prevedello
A 42-yr-old female presented with an olfactory groove meningioma causing progressive vision loss and anosmia. Given the size of the tumor, we opted for a 2-stage surgery: endoscopic endonasal approach (EEA) followed by a craniotomy. Stage I surgery was a transcribriform transplanum EEA using a binostril 4-hand/2 surgeons (ENT and neuro) technique, with the patient positioned supine with the head slightly turned to the right side and tilted to the left, fixed in a 3-pin head clamp, under imaging guidance, in which we drilled out all the affected skull base bone, devascularized and debulked the tumor...
April 16, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29668616/lung-metastases-from-intracranial-bleeding-meningioma-a-case-report
#9
Su Hu, Yaqi Zhang, Yue Sun, Yang Yu, Jia Wang, Hui Dai, Feng Sun, Chunhong Hu
RATIONALE: Meningioma is slow-growing benign neoplasm that derived from the meningothelial cells of the arachnoid mater, and it is the most common type of primary brain tumor. Although cases of extracranial metastatic meningioma have been reported previously, few cases have reported the concurrent occurrence of primary meningioma with intratumoral bleeding and lung metastases. Here we report a case of meningioma with concurrent intratumoral bleeding and lung metastases. PATIENT CONCERNS: The patient was admitted to our hospital with sudden left limb paralysis combined with complaints of headache and dizziness...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667084/investigation-of-the-aryl-hydrocarbon-receptor-and-the-intrinsic-tumoral-component-of-the-kynurenine-pathway-of-tryptophan-metabolism-in-primary-brain-tumors
#10
Anthony R Guastella, Sharon K Michelhaugh, Neil V Klinger, Hassan A Fadel, Sam Kiousis, Rouba Ali-Fehmi, William J Kupsky, Csaba Juhász, Sandeep Mittal
INTRODUCTION: There is mounting evidence supporting the role of tryptophan metabolism via the kynurenine pathway (KP) in the pathogenesis of primary brain tumors. Under normal physiological conditions, the KP is the major catabolic pathway for the essential amino acid tryptophan. However, in cancer cells, the KP becomes dysregulated, depletes local tryptophan, and contributes to an immunosuppressive tumor microenvironment. METHODS: We examined the protein expression levels (in 73 gliomas and 48 meningiomas) of the KP rate-limiting enzymes indoleamine 2,3-dioxygenase (IDO) 1, IDO2, and tryptophan 2,3-dioxygenase (TDO2), as well as, the aryl hydrocarbon receptor (AhR), a carcinogenic transcription factor activated by KP metabolites...
April 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29665752/histopathologic-findings-in-canine-pituitary-glands
#11
Margaret A Miller, David S Bruyette, J Catharine Scott-Moncrieff, Tina Jo Owen, José A Ramos-Vara, Hsin-Yi Weng, Andrea L Vanderpool, Annie V Chen, Linda G Martin, Deidre M DuSold, Sina Jahan
To optimize the histologic evaluation of hypophysectomy specimens, sections of 207 canine pituitary glands (196 postmortem, 11 hypophysectomy specimens) were reviewed. Adenohypophyseal proliferation was the most common (n = 79) lesion. Proliferative lesions were sparsely to densely granulated; the granules were usually basophilic to chromophobic and periodic acid-Schiff-positive. Adenohypophyseal proliferation was classified as hyperplasia (n = 40) if ≤2 mm diameter with intact reticulin network, as microadenoma (n = 22) for 1-5 mm homogeneous nodules with lost reticulin network, or as macroadenoma (n = 17) for larger tumors...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29663604/primary-extracranial-nasopharyngeal-meningioma-in-a-dog
#12
Emilie Fauchon, Jean-Charles Husson, Juan Hernandez, Eymeric Gomes
An 8-year-old Labrador Retriever was presented for inspiratory efforts with stertor. A rhinoscopy and a magnetic resonance imaging scan were performed and revealed a naso-pharyngeal mass. The mass was identified in the nasopharynx without meningeal extension. This mass was both T1- and T2-hyperintense, compared to normal brain parenchyma without significant postcontrast enhancement. The mass was surgically removed and the histologic diagnosis was a mesenchymal tumor. Immunohistochemistry with antibodies was conducted and consistent with an extracranial meningioma...
April 16, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29662628/a-gene-expression-signature-predicts-recurrence-free-survival-in-meningioma
#13
Adriana Olar, Lindsey D Goodman, Khalida M Wani, Nicholas S Boehling, Devi S Sharma, Reema R Mody, Joy Gumin, Elizabeth B Claus, Frederick F Lang, Timothy F Cloughesy, Albert Lai, Kenneth D Aldape, Franco DeMonte, Erik P Sulman
BACKGROUND: Meningioma is the most common primary brain tumor and has a variable risk of local recurrence. While World Health Organization (WHO) grade generally correlates with recurrence, there is substantial within-grade variation of recurrence risk. Current risk stratification does not accurately predict which patients are likely to benefit from adjuvant radiation therapy (RT). We hypothesized that tumors at risk for recurrence have unique gene expression profiles (GEP) that could better select patients for adjuvant RT...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29660031/meningioma-transcription-factors-link-cell-lineage-with-systemic-metabolic-cues
#14
Ziming Du, Ryan Brewster, Parker H Merrill, Juliann Chmielecki, Josh Francis, Ayal Aizer, Malak Abedalthagafi, Lynette M Sholl, Lars Geffers, Brian Alexander, Sandro Santagata
Background: Tumor cells recapitulate cell-lineage transcriptional programs that are characteristic of normal tissues from which they arise. It is unclear why such lineage programs are fatefully maintained in tumors and if they contribute to cell proliferation and viability. Methods: Here, we used the most common brain tumor, meningioma, which is strongly associated with female gender and high body mass index (BMI), as a model system to address these questions. We screened expression profiling data to identify the transcription factor (TF) genes which are highly enriched in meningioma, and characterized the expression pattern of those TFs and downstream genes in clinical meningioma samples as well as normal brain tissues...
April 12, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29660026/familial-syndromes-involving-meningiomas-provide-mechanistic-insight-into-sporadic-disease
#15
Keith Kerr, Krista Qualmann, Yoshua Esquenazi, John Hagan, Dong H Kim
Currently, there is an incomplete understanding of the molecular pathogenesis of meningiomas, the most common primary brain tumor. Several familial syndromes are characterized by increased meningioma risk, and the genetics of these syndromes provides mechanistic insight into sporadic disease. The best defined of these syndromes is neurofibromatosis type 2, which is caused by a mutation in the NF2 gene and has a meningioma incidence of approximately 50%. This finding led to the subsequent discovery that NF2 loss-of-function occurs in up to 60% of sporadic tumors...
April 11, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29649797/a-multimodal-approach-to-the-treatment-of-intraparenchymal-meningioma-in-a-7-year-old-boy-a-case-report
#16
Maria Caterina Vescovi, Daniele Bagatto, Gabriele Capo, Marta Maieron, Dario Marin, Enrico Pegolo, Barbara Tomasino
Intraparenchymal meningiomas are very rare: only 26 cases have been diagnosed in patients younger than 20 years since 1954. They can lead to preoperative differential diagnosis mistakes due to their atypical neuroimaging appearance. A multimodal approach is thus necessary to plan a surgical procedure aiming to receive the best extent of resection while preserving the patient's functional integrity. The authors report the case of a 7-year-old boy with a history of blurred vision, left eye deviation, and weakness on the left side of his body...
April 12, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29649644/endoscopic-transseptal-approach-with-a-bilateral-nasoseptal-flap-in-challenging-skull-base-tumors
#17
Do Hyun Kim, Yong-Kil Hong, Sin-Soo Jeun, Jae-Sung Park, Soo Whan Kim, Jin Hee Cho, Yong Jin Park, Sung Won Kim
OBJECTIVE: To examine the utility of an endoscopic transseptal approach and the creation of a bilateral nasoseptal flap using a two-nostrils/four-hands technique in patients with challenging skull-base tumors. METHODS: The medical records of patients operated on via an endoscopic transseptal approach between 2009 and 2017 were retrospectively reviewed. Two patients with ossifying fibroma, two with orbital hemangioma, two with trigeminal nerve schwannoma, and one patient each with juvenile angiofibroma, meningioma, and myxofibrosarcoma were included in the study...
April 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29644811/nanoparticle-enabled-experimentally-trained-wavelet-domain-denoising-method-for-optical-coherence-tomography
#18
Irina N Dolganova, Nikita V Chernomyrdin, Polina V Aleksandrova, Sheykh-Islyam T Beshplav, Alexander A Potapov, Igor V Reshetov, Vladimir N Kurlov, Valery V Tuchin, Kirill I Zaytsev
We present the nanoparticle-enabled experimentally trained wavelet-domain denoising method for optical coherence tomography (OCT). It employs an experimental training algorithm based on imaging of a test-object, made of the colloidal suspension of the monodisperse nanoparticles and contains the microscale inclusions. The geometry and the scattering properties of the test-object are known a priori allowing us to set the criteria for the training algorithm. Using a wide set of the wavelet kernels and the wavelet-domain filtration approaches, the appropriate filter is constructed based on the test-object imaging...
April 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29644810/cystic-meningiomas-correlation-between-radiologic-and-histopathologic-features
#19
Kyeong O Go, Kwangho Lee, Won Heo, Young Seok Lee, Young Seop Park, Sung Kwon Kim, Jeong Hee Lee, Jin Myung Jung
BACKGROUND: Tumors with cysts often correlate with gliomas, metastatic tumors, or hemangioblastomas, which require differentiation. METHODS: Thirty-eight cases of cyst associated-meningioma based on preoperative radiologic studies and histologic confirmations were reviewed from November 1998 to July 2017. RESULTS: A total of 395 cases of meningioma were observed in the 20 years, and surgical treatment of intracranial meningioma was performed in 120 cases...
April 2, 2018: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/29644809/optic-nerve-sheath-meningioma-preliminary-analysis-of-the-role-of-radiation-therapy
#20
Jun Jin, Jin Deok Joo, Jung Ho Han, Hee Kyung Yang, Jeong Min Hwang, Yi Jun Kim, In Ah Kim, Chae Yong Kim
BACKGROUND: The purpose of this study was to evaluate the treatment outcome of our optic nerve sheath meningioma (ONSM) case series in terms of preventing tumor growth and preserving vision in ONSM patients. METHODS: Between July 2003 and March 2015, 1,398 patients with intracranial meningioma were diagnosed at Seoul National University Bundang Hospital. Among them, only 13 patients (0.93%) were diagnosed with ONSM and enrolled in the present study. Tumor volume changes of ONSM patients and their visual acuity were evaluated before and after treatments...
April 2, 2018: Brain Tumor Research and Treatment
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