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Sophie Dorothee van der Linden, Margriet Maria Sitskoorn, Geert-Jan Maria Rutten, Karin Gehring
BACKGROUND: Many patients with primary brain tumors suffer from cognitive deficits, which negatively impact their quality of life. However, cognitive rehabilitation programs for these patients are scarce. We developed an iPad-based cognitive rehabilitation program for brain tumor patients, which was based on our effective face-to-face cognitive rehabilitation program. After successful completion of a feasibility study, a randomized controlled trial has been started. OBJECTIVE: To evaluate the immediate and long-term effects of the iPad-based program on cognitive performance and patient-reported outcome measures (PROMs) in patients with primary brain tumors in an early stage of the disease...
June 16, 2018: Neurosurgery
Suria Hussin, Siti Suhaila Mohd Yusoff, Faridah Mohd Zin, Ab Rahman Izaini Ghani
Frontal meningioma is often asymptomatic and patient may present with psychiatric symptoms. We report a case of 45- year-old female patient with no premorbid medical illness presented with 6 months history of depressive symptoms and changes in personality. Her worsening cognitive impairment brought her to psychiatry clinic and led to further investigation with contrast-enhanced computed tomography (CECT) Brain. The result showed well defined markedly enhancing lesion in the frontal region measuring 5.5 cm X5...
January 2018: Journal of Family Medicine and Primary Care
Schul B David, Meier P Michael, Földvari Zsouzsana, Matthias J Krammer, Lumenta B Christianto
BACKGROUND: Meningioma growing into an arachnoid cyst is an extremely rare event. Only three cases are reported in the literature. In two of them, an operative procedure in or near the arachnoid cyst preceded tumor growth. Schul CASE DESCRIPTION: We report a case of a patient requiring marsupialization of an arachnoid cyst of the middle cranial fossa. On follow-up, three years postoperatively he showed no signs of recurrence or tumor growth. One year later, the fourth year after cyst's surgery, he presented with large tumor growth into the former cyst's cavity...
June 15, 2018: World Neurosurgery
Sunil W Dutta, Jennifer L Peterson, Laura A Vallow, Anita Mahajan, Steven S Rosenfeld, Alfredo Quiñones-Hinojosa, Daniel M Trifiletti
PURPOSE: To analyze the national treatment trends of patients diagnosed with benign intracranial meningioma. METHODS AND MATERIALS: Data was obtained from the National Cancer Database (NCDB) for patients with WHO grade I meningioma tumors between 2004 and 2014 (190,527 patients), diagnosed by either surgical specimen or diagnostic imaging. Univariable and multivariable analyses (binary logistic models) were performed to generate odds ratios (OR) and investigate factors associated with definitive initial treatment compared to initial observation...
June 14, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Nicola Hare, Petros Georgopoulos, Kate E Philips, Joanne E Johnson, Coralie Seary, Jalesh N Panicker, Valerie L Stevenson
OBJECTIVE: Functional electrical stimulation is used to improve walking speed and reduces falls in people with upper motor neurone foot-drop. Following anecdotal observations of changes in bladder symptoms, an observational study was performed to explore this association further. DESIGN: A total of 47 consecutive patients attending for setup with functional electrical stimulation during a six-month period were asked to complete a questionnaire assessing bladder symptoms (ICIQ-OAB (International Consultation on Incontinence Questionnaire Overactive Bladder)) at baseline and three  months during routine appointments...
June 1, 2018: Clinical Rehabilitation
Georg Alexander Gihr, Diana Horvath-Rizea, Patricia Kohlhof-Meinecke, Oliver Ganslandt, Hans Henkes, Cindy Richter, Karl-Titus Hoffmann, Alexey Surov, Stefan Schob
BACKGROUND: Meningiomas are the most frequently diagnosed intracranial masses, oftentimes requiring surgery. Especially procedure-related morbidity can be substantial, particularly in elderly patients. Hence, reliable imaging modalities enabling pretherapeutic prediction of tumor grade, growth kinetic, realistic prognosis, and-as a consequence-necessity of surgery are of great value. In this context, a promising diagnostic approach is advanced analysis of magnetic resonance imaging data...
June 14, 2018: Translational Oncology
Xuan Wang, Meng-Yang Wang, Kang Qian, Long Chen, Fang-Cheng Zhang
OBJECTIVE: This study aims to investigate the importance and types of peritumoral draining veins in parasagittal and falcine meningiomas, and administer corresponding protective strategies during surgery according to these different types, in order to improve tumor resection rate and maximize the protection of neurological functions. METHODS: The clinical information of 156 patients with parasagittal and falcine meningiomas, who were admitted at the Neurosurgery Department of our hospital, was collected and retrospectively analyzed...
June 14, 2018: World Neurosurgery
Hongshun Xing, Shilei Wang, Quancai Li, Yongqian Ma, Peng Sun
Emerging evidence reveal that long noncoding RNAs (lncRNAs) participates in the epigenetic regulation of pathophysiological process. However, the deepgoing role of lncRNAs on meningioma is still unclear. In present study, we investigate the roles of lncRNA LINC00460 in meningeoma tissue and uncover its molecular mechanism. Results revealed that LINC00460 expression level was significantly up-regulated in meningeoma tissues and malignant meningeoma cell lines (IOMM-Lee, CH157-MN). Mechanically, loss-of-function assays showed that LINC00460 knockdown significantly suppressed the proliferation ability, increased the apoptosis and decreased the proteins (MMP-2, MMP-9, ZEB1) expression...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sung Hyun Noh, Kyung Hyun Kim, Dong Ah Shin, Jeong Yoon Park, Seong Yi, Sung Uk Kuh, Keung Nyun Kim, Dong Kyu Chin, Keun Su Kim, Do Heum Yoon, Yong Eun Cho
BACKGROUND CONTEXT: Because of the scarcity of atypical spinal meningioma, there is a lack of research on this type of tumor or its associated metastases. PURPOSE: The aim of this study was to investigate the biological behavior of atypical spinal meningioma and identify its prognostic factors by reviewing surgical and clinical outcomes of patients with these tumors. STUDY DESIGN/SETTING: A retrospective chart review was performed. PATIENT SAMPLE: We retrospectively reviewed the data from all patients who underwent spinal cord tumor excision between 1994 and 2017...
June 12, 2018: Spine Journal: Official Journal of the North American Spine Society
Luis David Jiménez-Franco, Peter Kletting, Ambros J Beer, Gerhard Glatting
PURPOSE: Peptide receptor radionuclide therapy (PRRT) has shown promising results in the treatment of tumors with high expression of somatostatin receptors such as neuroendocrine tumors (NETs) and meningioma. However, PRRT potentially produces high renal and red marrow (RM) toxicity, the kidneys usually being the dose-limiting organ. Previously, it was shown that an improved therapeutic index can be achieved by choosing an optimal combination of injected activity and peptide molar amount...
June 15, 2018: Medical Physics
Phillip M Radke, Peter A Herreid, Bryan S Sires
Primary extracranial meningioma is a rare tumor, unlike its common intracranial counterpart. Infrequently found in the head and neck region, it can cause local or neurologic symptoms depending on its location and interaction with cranial nerves. While uncommon, it is an important diagnosis to have on the differential of periorbital lesions as surgical removal and prognosis are generally good. The authors present the first report of a patient with primary extracranial meningioma originating in the lacrimal sac fossa...
June 13, 2018: Ophthalmic Plastic and Reconstructive Surgery
Devi Prasad Patra, Amey Rajan Savardekar, Rimal Hanif Dossani, Vinayak Narayan, Nasser Mohammed, Anil Nanda
The history of neurosurgery is ever fascinating. The journey has been tedious, nevertheless, in the landscape of success and failures we have become more efficient and polished. Skills were learned, innovations were made, and in the process we evolved. The immense contribution of meninigioma surgery in this maturation process is attested by history itself. Countless stories exist in the literature that would testify the momentous role of meningioma in the process of evolution and reformation of neurosurgical techniques...
June 11, 2018: World Neurosurgery
Pravin Salunke, Sushanta K Sahoo, Apinderpreeet Singh, Nishant Yagnik
The anterior clinoidal meningiomas often engulf /encase or compress Internal Carotid artery (ICA) and its branches, Optic nerve (ON) and structures passing through superior orbital fissure (SOF). The trans-sylvain route of excising tumour poses a difficulty in exposing and safeguarding encased vessels. In addition, it may jeopardize the bulging brain and stretched veins, especially in large tumors. The objective is to present an operative video to demonstrate the technique of 'centrifugal opening' and removal of anterior clinoidal meningiomas...
June 11, 2018: World Neurosurgery
Yabo Huang, Zhong Wang, Qingdong Han
RATIONALE: Tumor resection and extracranial-intracranial bypass concerning medial sphenoid ridge meningioma associated with severe stenosis of the internal carotid artery (ICA) of intracranial segments has been rarely presented. Effective treatment as to the complex lesions may be complicated. Tumor resection and cerebrovascular protection should be both taken into consideration. PATIENT CONCERNS: We presented one case of medial sphenoid ridge meningioma associated with severe stenosis of the internal carotid artery of intracranial segments...
June 2018: Medicine (Baltimore)
Shi-Yu Feng, Tao Zhou, Zheng-Hui Sun, Bo Bu, Jin-Li Jiang
The aim of the study was to explore anterior interhemispheric approach microsurgery for removing large sellar region tumors.A total of 118 patients with large sellar region tumors were treated with the anterior interhemispheric approach microsurgery. There were 58 craniopharyngioma, 37 pituitary adenoma, 5 hypothalamic glioma, 7 meningioma, and 11 other tumors cases. The maximal tumor diameter ranged from 3.0 to 8.2 cm, with a mean diameter of 4.3 cm. Diabetes insipidus and fluid and electrolyte imbalance were timely controlled after surgery...
June 2018: Medicine (Baltimore)
Laura Pinton, Samantha Solito, Elena Masetto, Marina Vettore, Stefania Canè, Alessandro Della Puppa, Susanna Mandruzzato
Meningiomas WHO grade I and II are common intracranial tumors in adults that normally display a benign outcome, but are characterized by a great clinical heterogeneity and frequent recurrence of the disease. Although the presence of an immune cell infiltrate has been documented in these tumors, a clear phenotypical and functional characterization of the immune web is missing. Here, we performed an extensive immunophenotyping of peripheral blood and fresh tumor tissue at surgery by multiparametric flow cytometry in 34 meningioma patients, along with immunosuppressive activity of sorted cells of myeloid origin...
2018: Oncoimmunology
Robbert Wylleman, Maria Debiec-Rychter, Raf Sciot
We report the exceptional occurrence of murine double minute clone 2 amplification in an atypical meningioma and its recurrent anaplastic meningioma arising in the right frontal lobe of a 75-year-old man. Murine double minute clone 2 amplification was shown by array comparative genomic hybridization and confirmed by fluorescence in situ hybridization. This is a rare finding with only one similar report in the literature. Awareness of this finding is indicated and should not lead to misdiagnosis of other entities that more commonly show this feature...
2018: Rare Tumors
Ashutosh Gupta, Charu Gupta, Monika Sachan, Sandeep Singh
Neurofibromatosis type 2 is a rare neurocutaneous syndrome characterized by the development of multiple nervous system tumors. This disorder is also called multiple inherited schwannomas, meningiomas, and ependymomas syndrome. In this report, we discuss the clinical and magnetic resonance imaging findings in a 17-year-old patient with neurofibromatosis type 2, who had extensive cranial nerves involvement (3rd-12th cranial nerves) along with spinal involvement. It is very rare to find tumors affect nearly all cranial nerves (namely 3rd-12th nerves), and their association with meningiomas and intramedullary spinal cord tumors in the same patient...
January 2018: Journal of Pediatric Neurosciences
Barbara Zollner, Ute Ganswindt, Cornelius Maihöfer, Stefanie Corradini, Nathalie Lisa Albert, Christian Schichor, Claus Belka, Maximilian Niyazi
BACKGROUND: The aim of the present study was to evaluate the influence of the applied safety margins of modern intensity-modulated radiotherapy (IMRT) in patients with high-grade meningiomas on local control and recurrence patterns. METHODS: Twenty patients with a neuropathological diagnosis of a high-grade meningioma (WHO°II or °III) treated with adjuvant or definitive radiotherapy between 2010 and 2015 were included in the present retrospective analysis. All patients were planned PET-based...
June 14, 2018: Radiation Oncology
Camille Pouchieu, Anne Gruber, Emilie Berteaud, Patrice Ménégon, Pascal Monteil, Aymeri Huchet, Jean-Rodolphe Vignes, Anne Vital, Hugues Loiseau, Isabelle Baldi
BACKGROUND: Although some countries have observed a stabilization in the incidence of CNS, an increasing incidence has been reported from multiple studies. Recent observations point out to the heterogeneity of incidence trends according to histological subtypes, gender and age-groups. Using a high-quality regional CNS tumor registry, this article describes the trends of CNS tumor incidence for main histological subtypes, including benign and malignant tumors, in the French department of Gironde from 2000 to 2012...
June 14, 2018: BMC Cancer
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