Read by QxMD icon Read


João Mauricio Castaldelli-Maia, Silvia S Martins, Carla L Storr, Maria C Viana, Laura H Andrade, Arthur G Andrade
We investigated the dimensionality and possible measurement bias of ICD-11 Nicotine Dependence (ND) criteria in a sample of smokers from a middle-income country. Data are from the São Paulo Megacity Project (part of World Mental Health Surveys) collected between 2005 and 2007 (n = 5,037). The current analyses were restricted to the 1,388 participants who smoked at least once a week for 2 months in their lifetime. Item response theory (IRT) was used to investigate the severity and discrimination properties of 8 selected criteria...
June 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
Hamidreza Pourzamani, Nezamaddin Mengelizadeh, Yaghoub Hajizadeh, Hamed Mohammadi
The electro-oxidation treatment of aqueous solution containing diclofenac (DCF) on a Ti/RuO2 -TiO2 electrode in the presence of multi-walled carbon nanotubes (MWCNTs) was studied in a three-dimensional electrochemical (3DE) reactor. The response surface methodology (RSM) based on central composite design (CCD) was utilized to determine the influence of different factors. The results revealed that the obtained polynomial experimental model had a high coefficient of determination (R2  = 0.9762) based on analysis of variance...
June 20, 2018: Environmental Science and Pollution Research International
Marin Kovacic, Jozefina Katic, Hrvoje Kusic, Ana Loncaric Bozic, Mirjana Metikos Hukovic
TiO₂-SnS₂ composite semiconducting photocatalysts with different building component ratios were prepared by hydrothermal synthesis (TiO₂-SnS₂-HT) and by immobilization of commercial TiO₂ and SnS₂ particles (TiO₂-SnS₂-COMM). The band gap values, which determine the catalysts’ photoactivity, were examined by diffuse reflectance spectroscopy and Kubelka⁻Munk transformations. The catalysts’ surface properties: specific surface area, charge and adsorption capacitance at the solid⁻solution interface were characterized using BET analysis, potentiometric titration and electrochemical impedance spectroscopy, respectively...
June 19, 2018: Materials
Takahito Sugase, Tomoki Makino, Makoto Yamasaki, Koji Tanaka, Tadayoshi Hashimoto, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Masayuki Mano, Eiichi Morii, Masaki Mori, Yuichiro Doki
INTRODUCTION: We aimed to analyze the clinical and histological effects of chemotherapy in superficial esophageal squamous cell carcinoma (SESCC). METHODS: We analyzed tumor samples from five patients with cT1bN1M0 who underwent subtotal esophagectomy following two courses of a new triplet chemotherapy regimen including docetaxel, cisplatin, and 5-fluorouracil (DCF). To assess the histological effects of chemotherapy, resected specimens were analyzed by macroscopic examination, hematoxylin & eosin (HE) staining, immunohistochemical (IHC) staining (p53, Ki-67 and cytokeratin) and periodic acid-Schiff (PAS) staining...
June 16, 2018: Esophagus: Official Journal of the Japan Esophageal Society
Teresa Balbi, Michele Montagna, Rita Fabbri, Cristina Carbone, Silvia Franzellitti, Elena Fabbri, Laura Canesi
Diclofenac-DCF, one of the most widely prescribed non-steroidal anti-inflammatory drug, is globally detected in environmental compartments. Due to its occurrence in freshwater and potential impact on aquatic organisms, it has been added to the watch list of chemicals in the EU Water Directive; consequently, research on the impact of DCF in model aquatic organisms has great regulatory implications towards ecosystem health. DCF is also detected in coastal waters at concentrations from ng/L to 1 μg/L, as well as in marine organisms, such as the mussel Mytilus...
June 14, 2018: Science of the Total Environment
Qingping He, Michelle Meadows
By treating each examination as a polytomous item and a grade that a student achieved in the exam as a score on the item, the partial credit model (PCM) has been used to analyse data from examinations in 16 GCSE subjects taken by 16-year olds in England. These examinations are provided by four different exam boards. By further treating students taking the exams testing the same subject but provided by different exam boards as different subgroups, differential category functioning (DCF) analysis was used to investigate the comparability of standards at specific grades in the examinations between the exam boards...
2018: Journal of Applied Measurement
Cho-Won Kim, Ryeo-Eun Go, Kyung-A Hwang, Ok-Nam Bae, Kyuhong Lee, Kyung-Chul Choi
Cigarette smoke contains thousands of harmful components, many of which exert toxic effects on reproductive organs, including the ovaries, and their development. In this study, we investigated the effects of cigarette smoke extract (CSE) on cell proliferation, apoptosis and oxidative stress in the SKOV3 and OVCAR3 ovarian cancer cell lines. A water soluble tetrazolium (WST) assay revealed that the cell proliferation of both ovarian cells was significantly inhibited by three types of CSE in a concentration-dependent manner...
June 9, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Guhuan Liu, Jinming Hu, Shiyong Liu
Homo- and hetero-bifunctional linkers play vital roles in constructing a variety of functional systems ranging from protein bioconjugates with drugs and functional agents, surface modification of nanoparticles and living cells, to the cyclization/ dimerization of synthetic polymers and biomolecules. Conventional approaches for assaying conjugation extents typically rely on ex situ techniques such as mass spectrometry, gel electrophoresis, and size-exclusion chromatograph. If the conjugation process involving bifunctional linkers was rendered fluorogenic, then in situ monitoring, quantification, and optical tracking/visualization of relevant processes will be achieved...
June 12, 2018: Chemistry: a European Journal
Zhaoxuan Feng, Karin Odelius, Minna Hakkarainen
A sustainable strategy to fabricate chitosan-based composite hydrogels with tunable properties and controllable adsorption capacity of trace pharmaceuticals was demonstrated. Two biobased modifiers were utilized to tune the properties, nano-graphene oxide (nGO) derived from chitosan via microwave-assisted carbonization and oxidation, and genipin as the crosslinking agent. An increase in genipin content facilitated an increase in the degree of crosslinking as shown by improved storage modulus and decreased swelling ratio...
September 15, 2018: Carbohydrate Polymers
Bénilde Bonnefille, Elena Gomez, Frédérique Courant, Aurélie Escande, Hélène Fenet
Interest in the presence and effects of diclofenac (DCF) and other pharmaceutical products (PPs) in the aquatic environment has been growing over the last 20 years. DCF has been included in the First Watch List of the EU Water Framework Directive in order to gather monitoring data in surface waters. Despite PP input in water bodies, few studies have been conducted to determine the extent of DCF occurrence and effects on marine ecosystems, which is usually the final recipient of surface waters. The present article reviews available published data on DCF occurrence in marine water, sediment and organisms, and its effects on marine organisms...
June 2018: Marine Pollution Bulletin
Miroslava Vosahlikova, Hana Ujcikova, Stanislav Musil, Lenka Roubalova, Martin Alda, Petr Svoboda
The functional state of δ-opioid receptor signalling cascade in live cells exposed to a therapeutic concentration of lithium for a prolonged period of time (weeks) is not known because the previous studies of Li interference with OR were oriented to µ-OR only. The same applies to the analysis of the prolonged effect of Li on oxidative stress in context with δ-OR function. HEK293 cells stably expressing δ-OR were cultivated in the presence or absence of 1 mM LiCl for 7 or 21 days, homogenized and the post-nuclear (PNS) and plasma membrane (PM) fractions prepared from all four types of cells...
June 5, 2018: Biochemical Pharmacology
Tao Zhou, Ke Feng, Wei Xiang, Yiliang Lv, Xiaohui Wu, Juan Mao, Chang He
In this study, significant synergistic degradation of antibiotic diclofenac (DCF) was demonstrated in a novel magnetic field (MF) enhanced zero-valent iron (ZVI)/EDTA Fenton-like system. Five operational parameters, namely, initial ZVI loading, pH, EDTA dosage, DCF concentration and reaction temperature, were investigated for their effects on the DCF degradation. OH was identified as the predominant reactive oxygen species for DCF degradation in ZVI/EDTA systems whether in the presence or absence of MF. DCF molecule can be oxidized by OH, attacking via the hydroxylation and substituted dechlorination of the chlorinated aromatic ring, as well as by dehydration between the N atom and the acetoxyl...
February 2018: Chemosphere
Junfeng Zhao, Qun Wang, Yongsheng Fu, Bo Peng, Gaofeng Zhou
In this study, the effect of Fe3+ , Fe2+ , and Mn2+ dose, solution pH, reaction temperature, background water matrix (i.e., inorganic anions, cations, and natural organic matters (NOM)), and the kinetics and mechanism for the reaction system of Fe(VI)/Fe3+ , Fe(VI)/Fe2+ , and Fe(VI)/Mn2+ were investigated systematically. Traces of Fe3+ , Fe2+ , and Mn2+ promoted the DCF removal by Fe(VI) significantly. The pseudo-first-order rate constant (kobs ) of DCF increased with decreasing pH (9-6) and increasing temperature (10-30 °C) due to the gradually reduced stability and enhanced reactivity of Fe(VI)...
June 1, 2018: Environmental Science and Pollution Research International
Jeong Su Ha, Jong Min Kim, Seon Kyeong Park, Jin Yong Kang, Du Sang Lee, Uk Lee, Dae-Ok Kim, Sung-Gil Choi, Ho Jin Heo
This study aimed to investigate the ameliorating effect of an ethyl acetate fraction from the fruit Actinidia arguta (EFAA) on amyloid beta (Aβ)-induced neurotoxicity and cognitive deficits in ICR mice. EFAA showed potent protective effects against Aβ-induced neurotoxicity through 2',7'-dichlorofluorescein diacetate (DCF-DA), 2',3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) release into the assay medium. EFAA treatment reduced the intracellular ROS level and lactate dehydrogenase (LDH) release in the mitochondria, and increased cell viability in Aβ-induced neuroblastoma MC-IXC cells...
May 22, 2018: Food & Function
Xukai Li, Weirui Chen, Yiming Tang, Laisheng Li
Fe-MCM-48 catalyst with a three-dimensional cubic pore structure was directly synthesized via a hydrothermal method, and the mineralization efficiency of diclofenac (DCF) in the catalytic ozonation process (Fe-MCM-48/O3 ) was assessed. X-ray diffraction (XRD), N2 adsorption desorption, transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) characterizations revealed that Fe existed in the framework of MCM-48, and Fe-MCM-48 possessed a large surface area and a highly ordered cubic mesoporous structure, which could accelerate reactants and products diffusion...
May 12, 2018: Chemosphere
Toshiyasu Ojima, Masaki Nakamura, Mikihito Nakamori, Masahiro Katsuda, Keiji Hayata, Shimpei Maruoka, Toshio Shimokawa, Hiroki Yamaue
Our previous trial with a docetaxel, cisplatin, and 5-fluorouracil (DCF) regimen showed high response rates in metastatic squamous cell carcinoma of the esophagus (SCCE). The observed increased toxicity of the DCF regimen, however, was clinically harmful. S-1, an oral anticancer drug, has been approved as a combination therapy for SCCE, and alternate-day regimen with S-1 has shown lower levels of toxicity. This prospective single-center phase I/II trial examines the efficacy and toxicity of a combination of docetaxel, cisplatin, and an alternate-day regimen of S-1 (modified DCS) for patients with metastatic SCCE...
May 16, 2018: Oncology
Yiming Su, David Jassby, Shikun Song, Xuefei Zhou, Hongying Zhao, Jan Filip, Eleni Petala, Yalei Zhang
Sulfidation of nanoscale zerovalent iron (nZVI) has shown some fundamental improvements on reactivity and selectivity towards pollutants in dissolved oxygen (DO) stimulated Fenton-like reaction systems (DO/S-nZVI system). However, the pristine micro-structure of sulfide modified nanoscale zerovalent iron (S-nZVI) remains uncovered. In addition, the relationship between pollutant removal and the oxidation of the S-nZVI is largely unknown. The present study confirms that sulfidation not only imparts sulfide and sulfate groups onto the surface of the nanoparticle (both on the oxide shell and on flake-like structures), but also introduces sulfur into the Fe(0) core region...
May 16, 2018: Environmental Science & Technology
Hilal Ahmad Rather, Ria Thakore, Ragini Singh, Dhwani Jhala, Sanjay Singh, Rajesh Vasita
Skin wound healing involves a coordinated cellular response to achieve complete reepithelialisation. Elevated levels of reactive oxygen species (ROS) in the wound environment often pose a hindrance in wound healing resulting in impaired wound healing process. Cerium oxide nanoparticles (CeNPs) have the ability to protect the cells from oxidative damage by actively scavenging the ROS. Furthermore, matrices like nanofibers have also been explored for enhancing wound healing. In the current study CeNP functionalised polycaprolactone (PCL)-gelatin nanofiber (PGNPNF) mesh was fabricated by electrospinning and evaluated for its antioxidative potential...
June 2018: Bioactive Materials
Monique A M de Jong, Jeroen J Briaire, Johan H M Frijns
OBJECTIVES: In an attempt to improve spectral resolution and speech intelligibility, several current focusing methods have been proposed to increase spatial selectivity by decreasing intracochlear current spread. For example, tripolar stimulation administers current to a central electrode and uses the two flanking electrodes as the return pathway, creating a narrower intracochlear electrical field and hence increases spectral resolution when compared with monopolar (MP) stimulation. However, more current is required, and in some patients, specifically the ones with high electrode impedances, full loudness growth cannot be supported because of compliance limits...
May 8, 2018: Ear and Hearing
Masahito Miura, Yuhto Taguchi, Tetsuya Handoh, Taiki Hasegawa, Yui Takahashi, Natsuki Morita, Ayana Matsumoto, Haruka Sato, Chiyohiko Shindoh
In diseased hearts, impaired muscle within the hearts is passively stretched by contractions of the more viable neighboring muscle during the contraction phase. We investigated whether in the myocardium with nonuniform contraction such passive stretch regionally generates ROS within the stretched region and exacerbates arrhythmias. In trabeculae from rat hearts, force, intracellular Ca2+ , and membrane potential were measured. To assess regional ROS generation, the slope of the change in the 2',7'-dichlorofluorescein fluorescence (DCFslope ) was calculated at the each pixel position along the long axis of trabeculae using DCF fluorescence images...
May 8, 2018: Pflügers Archiv: European Journal of Physiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"