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https://www.readbyqxmd.com/read/28549335/microstructural-alterations-of-white-matter-in-juvenile-myoclonic-epilepsy
#1
Jinnan Gong, Xuebin Chang, Sisi Jiang, Benjamin Klugah-Brown, Song Tan, Dezhong Yao, Cheng Luo
Juvenile myoclonic epilepsy (JME) is a common type of idiopathic generalized epilepsy that is characterized by myoclonic jerks of the upper limbs and generalized tonic-clonic seizures. Frontal cognitive dysfunctions and abnormal coupling of the thalamocortical system have been found in neuropsychological and neuroimaging studies. This study intended to explore white matter (WM) measurement changes in JME using MRI. Twenty-six patients with JME and 25 healthy controls (HC) were recruited for the acquisition of diffusion MRI and structural MRI data...
April 4, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28546825/efficient-isolation-of-magnolia-protoplasts-and-the-application-to-subcellular-localization-of-mdehsf1
#2
Yamei Shen, Dong Meng, Kim McGrouther, Junhong Zhang, Lailiang Cheng
BACKGROUND: Magnolia is a woody ornamental plant, which is widely used in urban landscaping. However, its lengthy juvenile period and recalcitrance to regeneration impedes functional characterization of its genes. RESULTS: We developed an efficient protoplast isolation and transient expression system for Magnolia denudata × Magnolia acuminata 'Yellow River'. The highest yield of protoplasts was obtained from young leaves digested in 3% Cellulase R10, 0.8% Macerozyme R10, 0...
2017: Plant Methods
https://www.readbyqxmd.com/read/28546508/stable-carbon-isotopes-in-breath-reveal-fast-incorporation-rates-and-seasonally-variable-but-rapid-fat-turnover-in-the-common-shrew-sorex-araneus
#3
Lara Keicher, M Teague O'Mara, Christian C Voigt, Dina K N Dechmann
Small non-migratory mammals with Northern distribution ranges apply a variety of behavioural and physiological wintering strategies. A rare energy saving strategy is Dehnel's phenomenon, involving a reduction and later regrowth of the body, several organs and parts of the skeleton in red-toothed shrews (Soricidae). The size extremes coincide with major life stages. Yet, the physiological consequences for the shrews' metabolism remain poorly understood. In keeping with the energetic limitations that may induce the size changes, we hypothesized that metabolic incorporation rates should remain the same across the shrews' lifetime...
May 25, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28546506/age-dependent-effects-of-water-striders-moving-on-perturbed-water-surfaces
#4
Victor Manuel Ortega-Jimenez, Lisa von Rabenau, Robert Dudley
Surface roughness is a ubiquitous phenomenon in both oceanic and terrestrial waters. For insects that live at the air-water interface, such as water striders, non-linear and multi-scale perturbations produce dynamic surface deformations which may impair locomotion. We studied escape jumps of adults, juveniles, and first-instar larvae of the water strider Aquarius remigis on smooth, wave-dominated, and bubble-dominated water surfaces. Effects of substrate on takeoff jumps were substantial, with significant reductions in take-off angles, peak translational speeds, attained heights, and power expenditure on more perturbed water surfaces...
May 25, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28546255/learning-the-hard-way-clinical-trials-in-juvenile-idiopathic-arthritis
#5
EDITORIAL
Roberta A Berard, Ronald M Laxer
No abstract text is available yet for this article.
May 25, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28545895/molluscicidal-potential-of-heterorhabditis-baujardi-rhabditida-heterorhabditidae-strain-lpp7-on-lymnaea-columella-gastropoda-pulmonata-an-alternative-for-biological-control-of-fasciolosis
#6
Victor Menezes Tunholi, Priscila de Oliveira Lorenzoni, Ygor Henrique da Silva, Vinícius Menezes Tunholi-Alves, Jankerle Neves Boeloni, Maria Aparecida da Silva, Caio Oliveira Monteiro, Márcia Cristina de Azevedo Prata, Jairo Pinheiro da Silva, Isabella Vilhena Freire Martins
This study elucidated for the first time, under laboratory conditions, the susceptibility of Lymnaea columella to infective juveniles of Heterorhabditis baujardi LPP7. Exposure to the nematodes induced an average mortality rate of 66.66% in the population of L. columella, with the highest values attained from the second week after exposure onward. In addition, all the reproductive parameters analyzed (total number of eggs, number of egg masses, number of eggs laid/snail, embryo hatching rate and content of galactogen stored in the albumen gland) changed as a result of the infection...
May 22, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28545131/major-changes-in-microbial-diversity-and-community-composition-across-gut-sections-of-a-juvenile-panchlora-cockroach
#7
Erin A Gontang, Frank O Aylward, Camila Carlos, Tijana Glavina Del Rio, Mansi Chovatia, Alison Fern, Chien-Chi Lo, Stephanie A Malfatti, Susannah G Tringe, Cameron R Currie, Roberto Kolter
Investigations of gut microbiomes have shed light on the diversity and genetic content of these communities, and helped shape our understanding of how host-associated microorganisms influence host physiology, behavior, and health. Despite the importance of gut microbes to metazoans, our understanding of the changes in diversity and composition across the alimentary tract, and the source of the resident community are limited. Here, using community metagenomics and 16S rRNA gene sequencing, we assess microbial community diversity and coding potential in the foregut, midgut, and hindgut of a juvenile Panchlora cockroach, which resides in the refuse piles of the leaf-cutter ant species Atta colombica...
2017: PloS One
https://www.readbyqxmd.com/read/28545118/atopy-in-children-with-juvenile-systemic-lupus-erythematosus-is-associated-with-severe-disease
#8
Ruru Guo, Yanqing Zhou, Liangjing Lu, Lanfang Cao, Junjia Cao
The influence of co-existing atopy on the prognosis of juvenile systemic lupus erythematosus (JSLE) was assessed in this study. Patients diagnosed with JSLE between October 2005 and April 2016 were enrolled in a prospective study and followed up for 2 years. Management of patients was evaluated using the systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) score and laboratory variables. Eighty JSLE patients were enrolled at diagnosis and divided into those with (n = 35) and without (n = 45) atopy...
2017: PloS One
https://www.readbyqxmd.com/read/28544889/juvenile-myoclonic-epilepsy-as-a-spectrum-disorder-a-focused-review
#9
REVIEW
Betül Baykan, Peter Wolf
In consequence of newer research juvenile myoclonic epilepsy (JME) is no longer seen as a homogeneous disease. The causes of the existing variance are only partially known yet. We discuss to what extent the phenotypical spectrum of this polygenetically determined disorder expresses genetically defined endophenotypes, or is due to mere quantitative differences in the expression of the core phenotype. Of the three common seizure types of JME, myoclonic, generalized tonic-clonic and absences, absences also occur independently and are strong candidates for an endophenotype...
May 18, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28544235/absence-of-juvenile-hormone-signalling-regulates-the-dynamic-expression-profiles-of-nutritional-metabolism-genes-during-diapause-preparation-in-the-cabbage-beetle-colaphellus-bowringi
#10
W Liu, Q-Q Tan, L Zhu, Y Li, F Zhu, C-L Lei, X-P Wang
Temperate insects have evolved diapause, a period of programmed developmental arrest during specific life stages, to survive unfavourable conditions. During the diapause preparation phase (DPP), diapause-destined individuals generally store large amounts of fat by regulating nutrition distribution for the energy requirement during diapause maintenance and postdiapause development. Although nutritional patterns during the DPP have been investigated at physiological and biochemical levels in many insects, it remains largely unknown how nutritional metabolism is regulated during the DPP at molecular levels...
May 20, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/28543958/latent-structure-of-negative-valence-measures-in-childhood
#11
Minyoung Lee, Steven H Aggen, Dever M Carney, Shannon Hahn, Elizabeth Moroney, Laura Machlin, Melissa A Brotman, Kenneth E Towbin, Ellen Leibenluft, Daniel S Pine, Roxann Roberson-Nay, John M Hettema
BACKGROUND: Internalizing disorders (IDs), consisting of the syndromes of anxiety and depression, are common, debilitating conditions often having onsets in adolescence. Scientists have developed dimensional self-report instruments that assess putative negative valence system (NVS) trait-like constructs as complimentary phenotypes to clinical symptoms. These include various measures that index temperamental predispositions to IDs and correlate with neural substrates of fear, anxiety, and affective regulation...
May 22, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28543792/lichenoid-drug-eruption-with-prominent-nail-changes-due-to-leflunomide-in-a-12-year-old-child
#12
Caitlin May, Philip Fleckman, Heather A Brandling-Bennett, Bonnie Cole, Robert Sidbury
We present the case of a 12-year-old-girl who developed lichenoid dermatitis approximately 1 year after starting leflunomide for juvenile idiopathic arthritis. The eruption resolved promptly with discontinuation of the suspected culprit agent, supportive of a lichenoid drug eruption, but she subsequently developed markedly dystrophic nails with lichen planus-like features. A biopsy of her cutaneous findings at the time of initial presentation demonstrated lichenoid dermatitis, and a nail matrix biopsy was deferred given clinical correlation...
May 23, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28543059/natural-pathology-of-the-captive-chimpanzee-pan-troglodytes-a-35-year-review
#13
REVIEW
Shyamesh Kumar, Hannah Laurence, Michael A Owston, R Mark Sharp, Priscilla Williams, Robert E Lanford, Gene B Hubbard, Edward J Dick
We present the spontaneous pathological lesions identified as a result of necropsy or biopsy for 245 chimpanzees (Pan troglodytes) over a 35-year period. A review of the pathology database was performed for all diagnoses on chimpanzees from 1980 to 2014. All morphologic diagnoses, associated system, organ, etiology, and demographic information were reviewed and analyzed. Cardiomyopathy was the most frequent lesion observed followed by hemosiderosis, hyperplasia, nematodiasis, edema, and hemorrhage. The most frequently affected systems were the gastrointestinal, cardiovascular, urogenital, respiratory, and lymphatic/hematopoietic systems...
May 23, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28542850/reproductive-biology-of-black-seabream-acanthopagrus-schlegelii-threadfin-porgy-evynnis-cardinalis-and-red-pargo-pagrus-major-in-the-northern-south-china-sea-with-consideration-of-fishery-status-and-management-needs
#14
C S W Law, Y Sadovy de Mitcheson
The reproductive biology of three commercially significant seabream species (family: Sparidae) Acanthopagrus schlegelii, Evynnis cardinalis and Pagrus major, taken from Hong Kong and adjacent northern South China Sea (SCS) waters, were investigated for their sexual patterns, spawning seasons, length at maturity and exploitation in relation to their conservation and management status. Histological analysis showed E. cardinalis and P. major to be functionally gonochoristic, the latter having a bisexual juvenile stage and being a rudimentary hermaphrodite...
May 23, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28542676/detailed-clinical-phenotype-and-molecular-genetic-findings-in-cln3-associated-isolated-retinal-degeneration
#15
Cristy A Ku, Sarah Hull, Gavin Arno, Ajoy Vincent, Keren Carss, Robert Kayton, Douglas Weeks, Glenn W Anderson, Ryan Geraets, Camille Parker, David A Pearce, Michel Michaelides, Robert E MacLaren, Anthony G Robson, Graham E Holder, Elise Heon, F Lucy Raymond, Anthony T Moore, Andrew R Webster, Mark E Pennesi
Importance: Mutations in genes traditionally associated with syndromic retinal disease are increasingly found to cause nonsyndromic inherited retinal degenerations. Mutations in CLN3 are classically associated with juvenile neuronal ceroid lipofuscinosis, a rare neurodegenerative disease with early retinal degeneration and progressive neurologic deterioration, but have recently also been identified in patients with nonsyndromic inherited retinal degenerations. To our knowledge, detailed clinical characterization of such cases has yet to be reported...
May 25, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28542424/development-of-behavioural-profile-in-the-northern-common-boa-boa-imperator-repeatable-independent-traits-or-personality
#16
Olga Šimková, Petra Frýdlová, Barbora Žampachová, Daniel Frynta, Eva Landová
Recent studies of animal personality have focused on its proximate causation and ecological and evolutionary significance in particular, but the question of its development was largely overlooked. The attributes of personality are defined as between-individual differences in behaviour, which are consistent over time (differential consistency) and contexts (contextual generality) and both can be affected by development. We assessed several candidates for personality variables measured in various tests with different contexts over several life-stages (juveniles, older juveniles, subadults and adults) in the Northern common boa...
2017: PloS One
https://www.readbyqxmd.com/read/28542189/mir-277-4989-regulate-transcriptional-landscape-during-juvenile-to-adult-transition-in-the-parasitic-helminth-schistosoma-mansoni
#17
Anna V Protasio, Stijn van Dongen, Julie Collins, Leonor Quintais, Diogo M Ribeiro, Florian Sessler, Martin Hunt, Gabriel Rinaldi, James J Collins, Anton J Enright, Matthew Berriman
Schistosomes are parasitic helminths that cause schistosomiasis, a disease affecting circa 200 million people, primarily in underprivileged regions of the world. Schistosoma mansoni is the most experimentally tractable schistosome species due to its ease of propagation in the laboratory and the high quality of its genome assembly and annotation. Although there is growing interest in microRNAs (miRNAs) in trematodes, little is known about the role these molecules play in the context of developmental processes...
May 23, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28541240/homosexuality-according-to-ancient-greek-physicians
#18
K Laios, M M Moschos, E Koukaki, M-I Kontaxaki, G Androutsos
Homosexuality and pedophilia in ancient Greece greatly concerned many researchers who were mainly interested in highlighting the social aspect of this phenomenon in ancient Greek society. An important source on the subject was the paintings of a man and his lover in attic black and red figured pottery, up to the end of the 5th century BC. Another main source was the information that derived from the texts of ancient Greek literature, especially poetry. Homosexuality was not only referring to relationships between males, but it was also manifested in lesbian love...
January 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28540607/treatment-response-to-etanercept-in-methotrexate-refractory-juvenile-idiopathic-arthritis-an-analysis-of-predictors-and-long-term-outcomes
#19
Yueh Su, Yao-Hsu Yang, Bor-Luen Chiang
The aim of the study is to evaluate the long-term outcomes, predictors, and the role of inflammatory cytokines in methotrexate (MTx) refractory juvenile idiopathic arthritis (JIA) patients. This is a retrospective cohort study. MTx refractory JIA patients who received etanercept as their first biological agent in National Taiwan University Hospital (NTUH) were enrolled. Patients were classified into remission group, non-remission group, relapsing group, and non-relapsing group according to the criteria of disease remission and disease flares defined by Wallace et al...
May 24, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28540596/the-effect-of-growth-rate-and-ageing-on-colour-variation-of-european-pond-turtles
#20
Alejandro Ibáñez, José Martín, Alfonso Marzal, Albert Bertolero
Many chelonians have colourful dots, patches and stripes throughout their body that are made up, at least in part, of carotenoids. Therefore, turtles are very suitable models to study the evolution and functionality of carotenoid-based colouration. Recent studies suggested a close link between colouration and immune system in these taxa. However, more research is needed to understand the role of these colourful stripes and patches in turtle visual signalling. The purpose of this study was to explore the relationship between growth rate and colouration in European pond turtles...
June 2017: Die Naturwissenschaften
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