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https://www.readbyqxmd.com/read/28718287/preparation-of-3-iodoquinolines-from-n-tosyl-2-propynylamines-with-diaryliodonium-triflate-and-n-iodosuccinimide
#1
Teppei Sasaki, Katsuhiko Moriyama, Hideo Togo
4-Aryl- and 4-alkyl substituted 3-iodoquinolines could be smoothly obtained in one pot by treating N-tosyl-2-propynylamines with diaryliodonium triflate in the presence of K3PO4 and a catalytic amount of CuCl at room temperature, followed by treatment with N-iodosuccinimide and BF3•OEt2 at 0 °C, and then NaOH in methanol solution. The product, 3-iodo-4-phenylquinoline was smoothly transformed into 4-phenylquinoline with zinc; 4-phenyl-3-toluenesulfenylquinoline with toluenethiol, K2CO3, and CuI; 4-phenyl-3-phenylethynylquinoline with the Sonogashira coupling reaction; 4-phenyl-3-styrylquinoline with the Heck coupling reaction; 3,4-diphenylquinoline with the Suzuki-Miyaura coupling reaction; 2-cyclohexyl-3-iodo-4-phenylquinoline with cyclohexanecarboxylic acid, Ag2CO3, and K2S2O8; and 3-iodo-2-(2',5'-dioxan-1'-yl)-4-phenylquinoline with benzoyl peroxide in 1,4-dioxane...
July 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28717698/neuroblastoma-in-africa-a-survey-by-the-franco-african-pediatric-oncology-group
#2
Fousseyni Traoré, Francis Eshun, Boubacar Togo, Jean Jacques Atteby Yao, Mbuli Robert Lukamba
PURPOSE: Neuroblastoma is a sympathoadrenal lineage neural crest-derived tumor. It is the third most common childhood malignancy in the Western world. Studies from the United States show that black patients with neuroblastoma have a greater proportion of high-risk neuroblastoma with poorer prognosis compared with white patients. In Africa, there are few published data on the epidemiology and management of neuroblastoma. The primary aim of this study was to assess the diagnostic and therapeutic resources available for the management of neuroblastoma within the Franco-African Pediatric Oncology Group (GFAOP)...
August 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28713359/exploring-the-diversity-of-field-strains-of-brucella-abortus-biovar-3-isolated-in-west-africa
#3
Moussa Sanogo, David Fretin, Eric Thys, Claude Saegerman
Brucellosis is one of the most widespread bacterial zoonotic diseases in the world, affecting both humans and domestic and wild animals. Identification and biotyping of field strains of Brucella are of key importance for a better knowledge of the epidemiology of brucellosis, for identifying appropriate antigens, for managing disease outbreaks and for setting up efficient preventive and control programmes. Such data are required both at national and regional level to assess potential threats for public health...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28706850/pneumothorax-caused-by-cystic-and-nodular-lung-metastases-from-a-malignant-uterine-perivascular-epithelioid-cell-tumor-pecoma
#4
Shouichi Okamoto, Moegi Komura, Yasuhisa Terao, Aiko Kurisaki-Arakawa, Takuo Hayashi, Tsuyoshi Saito, Shinsaku Togo, Akira Shiokawa, Keiko Mitani, Etsuko Kobayashi, Toshio Kumasaka, Kazuhisa Takahashi, Kuniaki Seyama
Perivascular epithelioid cell tumors (PEComas) are mesenchymal neoplasms with immunoreactivity for both melanocytic and smooth muscle markers. PEComas occur at multiple sites, and malignant PEComas can undergo metastasis, recurrence and aggressive clinical courses. Although the lung is a common metastatic site of PEComas, they usually appear as multiple nodules but rarely become cystic or cavitary. Here, we describe a female patient whose lungs manifested multiple cystic, cavity-like and nodular metastases 3 years after the resection of uterine tumors tentatively diagnosed as epithelioid smooth muscle tumors with uncertain malignant potential...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28699235/expression-patterns-of-claudins-in-patients-with-triple-negative-breast-cancer-are-associated-with-nodal-metastasis-and-worse-outcome
#5
Ayaka Katayama, Tadashi Handa, Kei Komatsu, Maria Togo, Jun Horiguchi, Masahiko Nishiyama, Tetsunari Oyama
Claudins (CLDNs) are key cell adhesion molecules, which compose tight junctions (TJs), and the disruption of TJs is associated with cancer development. Here we immunohistochemically studied expression patterns of CLDNs in 222 primary invasive breast cancers including 68 triple-negative breast cancers (TNBCs), and examined their correlation with epithelial-to-mesenchymal transition (EMT)-related markers, breast cancer stem cell (BCSC) markers, and clinicopathological features including patients' clinical outcome...
July 11, 2017: Pathology International
https://www.readbyqxmd.com/read/28660604/-hiv-prevalence-and-behavioral-studies-among-female-sex-workers-in-togo-in-2015
#6
J N Teclessou, S Akakpo, D Gbetoglo, G Koumagnanou, A Singo, P Pitché
The purpose of this study is to determine the seroprevalence of HIVamong female sex workers (FSWs) and to document the behavior in this target population four years after the last study and possibly readjust these interventions. We conducted from March 27 to April 4, 2015 a crosssectional study of 1197 FSWs. Behavior data were collected by interviewer-administered questionnaires. The FSWs were then subjected to blood tests to measure the prevalence of HIV. The average age of respondents FSWs was 28 years and 20% had their first sexual intercourse before 15 years old...
June 28, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28642581/molecular-methods-to-detect-spodoptera-frugiperda-in-ghana-and-implications-for-monitoring-the-spread-of-invasive-species-in-developing-countries
#7
Matthew J W Cock, Patrick K Beseh, Alan G Buddie, Giovanni Cafá, Jayne Crozier
Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae) is a polyphagous pest indigenous throughout the Americas, which recently appeared in Africa, first reported from São Tomé, Nigeria, Bénin and Togo in 2016, and which we now report from Ghana. This species is recognised to comprise two morphologically identical but genetically distinct strains or species in the Americas, and we found both to be present in Ghana. We discuss possible routes of entry to Africa, of which the likeliest is adults and/or egg masses transported on direct commercial flights between the Americas and West Africa, followed by dispersal by adult flight within Africa...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28641892/fighting-fake-medicines-first-quality-evaluation-of-cardiac-drugs-in-africa
#8
Marie Antignac, Bara Ibrahima Diop, Diane Macquart de Terline, Melisande Bernard, Bernard Do, Stéphane Méo Ikama, Roland N'Guetta, Dadhi M Balde, Yessoufou Tchabi, Abdallahi Sidi Aly, Ibrahim Ali Toure, Patrick Zabsonre, Jean Marie F Damorou, Jean Laurent Takombe, Christine Fernandez, Muriel Tafflet, Jean Philippe Empana, Pierre François Plouin, Kumar Narayanan, Eloi Marijon, Xavier Jouven
BACKGROUND: The growing menace of poor quality and falsified drugs constitutes a major hazard, compromising healthcare and patient outcomes. Efforts to assess drug standards worldwide have almost exclusively focused on anti-microbial drugs; with no study to date on cardiovascular drugs. Our study aims to assess quality of seven routinely used cardiovascular medications (anticoagulants, antihypertensives and statins) in ten Sub-Saharan African countries. METHODS: Drugs were prospectively collected using standardized methods between 2012 and 2014 from licensed (random pharmacies) and unlicensed (street-markets) places of sale in Africa...
June 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28603828/profile-of-bone-malignancy-among-rheumatology-inpatients-in-lom%C3%A3-togo
#9
Kodjo Kakpovi, Owonayo Oniankitan, Messanvi Kpoti, Prénam Houzou, Viwalé Es Koffi-Tessio, Komi C Tagbor, Eyram Fianyo, Moustafa Mijiyawa
BACKGROUND: The incidence of bone malignancy in adulthood seems poorly known in Black Africa. AIM: To determine the epidemiological, clinical, and paraclinical profile of bone malignancy in patients admitted to the Rheumatology Department in Lomé (Togo). METHODS: A retrospective study was conducted over 19 years on records of hospital patients admitted for bone malignancy. RESULTS: One hundred sixty-six of 2018 (8.2%) patients (98 men and 68 women) admitted suffered from bone malignancy...
August 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28602653/infrasonic-and-ultrasonic-hearing-evolved-after-the-emergence-of-modern-whales
#10
Mickaël J Mourlam, Maeva J Orliac
Mysticeti (baleen whales) and Odontoceti (toothed whales) today greatly differ in their hearing abilities: Mysticeti are presumed to be sensitive to infrasonic noises [1-3], whereas Odontoceti are sensitive to ultrasonic sounds [4-6]. Two competing hypotheses exist regarding the attainment of hearing abilities in modern whales: ancestral low-frequency sensitivity [7-13] or ancestral high-frequency sensitivity [14, 15]. The significance of these evolutionary scenarios is limited by the undersampling of both early-diverging cetaceans (archaeocetes) and terrestrial hoofed relatives of cetaceans (non-cetacean artiodactyls)...
June 19, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28602443/-benign-neonatal-hemangiomatosis-an-observation-in-a-child-in-togo
#11
G Mahamadou, B Saka, A Mouhari-Toure, M Tchaou, S Pessinaba, W Gnassingbé, K Kombaté, P Pitché
No abstract text is available yet for this article.
June 8, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28592935/surgery-on-burns-sequelae-in-developing-countries
#12
O El Ezzi, M Dolci, C Dufour, R Bossou, A de Buys Roessingh
The purpose of this study is to analyze the effectiveness of surgery and follow-up of children operated on for burn sequelae. For many years, we have organized two missions per year to Benin and Togo, one for surgery and one for follow-up. We analyzed the files of children born in Africa and victims of burns from the years 2002 to 2011. Children were referred through a non-governmental organization (NGO) and assessed in Africa by local paediatricians before and after surgery. Treatment consisted in operating on burn sequelae such as contractures, hypertrophic scars and hard cords...
March 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28589394/single-and-chronic-l-serine-treatments-exert-antidepressant-like-effects-in-rats-possibly-by-different-means
#13
Mao Nagasawa, Tsuyoshi Otsuka, Yuki Togo, Masakazu Yamanaga, Junki Yoshida, Nobuo Uotsu, Sachiyuki Teramoto, Shinobu Yasuo, Mitsuhiro Furuse
In the present study, the effects of both single (6 mmol L-serine/10 ml/kg orally administrated) and chronic (2% L-serine solution freely given for 28 days) treatments on depression-like behavior were evaluated in Wistar rats, representing the control, and Wistar Kyoto rats, representing an animal model of depression. Both single and chronic L-serine treatments decreased the duration of immobility, which is an index of a depressive-like state, in the forced swimming test in both strains. However, the decreases in the duration of immobility appear to be regulated differently by the different mechanisms involved in single and chronic L-serine treatments...
June 6, 2017: Amino Acids
https://www.readbyqxmd.com/read/28561454/hepatitis-b-treatment-eligibility-in-west-africa-uncertainties-and-need-for-prospective-cohort-studies
#14
Antoine Jaquet, Marcellin Nouaman, Judicaël Tine, Aristophane Tanon, Camille Anoma, André Inwoley, Alain Attia, Didier K Ekouevi, Moussa Seydi, François Dabis, Gilles Wandeler
BACKGROUND & AIMS: While universal screening of hepatitis B virus (HBV) is recommended in high burden countries, little is known about the proportion of HBV-infected persons in need of antiviral therapy in these settings. METHODS: Prisoners in Senegal and Togo as well as female sex workers and men who have sex with men in Cote d'Ivoire were screened for HBV infection. All HBsAg-positive participants underwent transient elastography, alanine aminotransferase (ALT) and HBV viral load (VL) quantification...
May 31, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28556409/prevention-of-infectious-complications-after-prostate-biopsy-procedure
#15
REVIEW
Yoshikazu Togo, Shingo Yamamoto
Although febrile complications are rarely encountered after a prostate biopsy procedure, in recent years the number of cases of fatal infection after that have increased along with increases in resistant bacteria. The available biopsy approaches are transrectal and transperineal, with the transrectal approach primarily used. As the invasion path of the puncture needle differs between these approaches, pretreatment and the method of administration of preventive antimicrobial drugs should be separately considered for infection prevention...
May 27, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28552989/structure-of-sweet-potato-ipomoea-batatas-diversity-in-west-africa-covaries-with-a-climatic-gradient
#16
Kodjo Glato, Atsou Aidam, Ndjido Ardo Kane, Diallo Bassirou, Marie Couderc, Leila Zekraoui, Nora Scarcelli, Adeline Barnaud, Yves Vigouroux
Sub-Saharan agriculture has been identified as vulnerable to ongoing climate change. Adaptation of agriculture has been suggested as a way to maintain productivity. Better knowledge of intra-specific diversity of varieties is prerequisites for the successful management of such adaptation. Among crops, root and tubers play important roles in food security and economic growth for the most vulnerable populations in Africa. Here, we focus on the sweet potato. The Sweet potato (Ipomoea batatas) was domesticated in Central and South America and was later introduced into Africa and is now cultivated throughout tropical Africa...
2017: PloS One
https://www.readbyqxmd.com/read/28545721/impact-of-menafrivac-in-nine-countries-of-the-african-meningitis-belt-2010-15-an-analysis-of-surveillance-data
#17
Caroline L Trotter, Clément Lingani, Katya Fernandez, Laura V Cooper, André Bita, Carol Tevi-Benissan, Olivier Ronveaux, Marie-Pierre Préziosi, James M Stuart
BACKGROUND: In preparation for the introduction of MenAfriVac, a meningococcal group A conjugate vaccine developed for the African meningitis belt, an enhanced meningitis surveillance network was established. We analysed surveillance data on suspected and confirmed cases of meningitis to quantify vaccine impact. METHODS: We compiled and analysed surveillance data for nine countries in the meningitis belt (Benin, Burkina Faso, Chad, Côte d'Ivoire, Ghana, Mali, Niger, Nigeria, and Togo) collected and curated by the WHO Inter-country Support Team between 2005 and 2015...
May 22, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28545675/changes-in-viral-hepatitis-b-screening-practices-over-time-in-west-african-hiv-clinics
#18
P A Coffie, A Patassi, A Doumbia, G Bado, E Messou, A Minga, E Allah-Kouadio, D M Zannou, M Seydi, A R Kakou, F Dabis, G Wandeler
BACKGROUND: We aimed to describe changes in hepatitis B screening practices over a 3-year period among HIV-infected patients in West Africa. METHODS: A medical chart review was conducted in urban HIV treatment centers in Ivory Coast (3 sites), Benin, Burkina Faso, Senegal, and Togo (1 site each). Among patients who started antiretroviral treatment between 2010 and 2012, 100 per year were randomly selected from each clinic. Demographic, clinical, and laboratory data was collected using a standardized questionnaire...
May 22, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28542166/indoor-secondhand-tobacco-smoke-and-risk-of-under-five-mortality-in-23-sub-saharan-africa-countries-a-population-based-study-and-meta-analysis
#19
Patrick Opiyo Owili, Miriam Adoyo Muga, Wen-Chi Pan, Hsien-Wen Kuo
BACKGROUND: Inhalation of secondhand smoke from tobacco results in serious health outcomes among under-five children, and yet, few studies have assessed its effect on under-five mortality. We investigated the association between frequency of exposure to household tobacco smoke and risk of under-five mortality in sub-Saharan Africa (SSA). METHODS: Demographic Health Survey data of under-five children from 23 SSA countries (n = 787,484) were used. Cox proportional hazard models described the association between exposure to tobacco smoke and the risk of under-five mortality in each country, with age as the time-to-event indicator...
2017: PloS One
https://www.readbyqxmd.com/read/28540900/quality-of-life-of-hemodialysis-patients-in-togo-a-single-center-study-on-64-hemodialysis-patients-at-the-sylvanus-olympio-university-hospital-in-lom%C3%A3-togo
#20
Kossi Akomola Sabi, Béfa Noto-Kadou-Kaza, Eyram Yoan Amekoudi, Jacques Vigan, Kokou Ayamekpe, Dégnon Amedegnato
This study aims at assessing patients' quality of life during hemodialysis (HD) and determining influencing factors. This prospective study was conducted over a three-month period (December 1, 2012-February 28, 2013) at the Sylvanus Olympio University Hospital (CHU-SO) HD unit, the only center to provide such services in Togo. Respondents used the standard Medical Outcome Survey-Short Form 36 questionnaire. This study was conducted on 64 patients (44 males and 20 females = M/F ratio 2.2). Mean patient age was 45...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
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