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https://www.readbyqxmd.com/read/27920899/diagnosing-clean-margins-through-raman-spectroscopy-in-human-and-animal-mammary-tumour-surgery-a-short-review
#1
REVIEW
I A Birtoiu, C Rizea, D Togoe, R M Munteanu, C Micsa, M I Rusu, M Tautan, L Braic, L O Scoicaru, A Parau, N D Becherescu-Barbu, M V Udrea, A Tonetto, R Notonier, C E A Grigorescu
Breast cancer frequency in human and other mammal female populations has worryingly increased lately. The acute necessity for taxonomy of the aetiological factors along with seeking for new diagnostic tools and therapy procedures aimed at reducing mortality have yielded in an intense research effort worldwide. Surgery is a regular method to counteract extensive development of breast cancer and prevent metastases provided that negative surgical margins are achieved. This highly technical challenge requires fast, extremely sensitive and selective discrimination between malignant and benign tissues even down to molecular level...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27905298/haploinsufficiency-of-the-folliculin-gene-leads-to-impaired-functions-of-lung-fibroblasts-in-patients-with-birt-hogg-dub%C3%A3-syndrome
#2
Yoshito Hoshika, Fumiyuki Takahashi, Shinsaku Togo, Muneaki Hashimoto, Takeshi Nara, Toshiyuki Kobayashi, Fariz Nurwidya, Hideyuki Kataoka, Masatoshi Kurihara, Etsuko Kobayashi, Hiroki Ebana, Mika Kikkawa, Katsutoshi Ando, Koichi Nishino, Okio Hino, Kazuhisa Takahashi, Kuniaki Seyama
Birt-Hogg-Dubé syndrome (BHDS) is an autosomal dominant inherited disorder caused by germline mutations in the FLCN gene, and characterized by skin fibrofolliculomas, multiple lung cysts, spontaneous pneumothorax, and renal neoplasms. Pulmonary manifestations frequently develop earlier than other organ involvements, prompting a diagnosis of BHDS However, the mechanism of lung cyst formation and pathogenesis of pneumothorax have not yet been clarified. Fibroblasts were isolated from lung tissues obtained from patients with BHDS (n = 12) and lung cancer (n = 10) as controls...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27895063/association-of-eating-behaviours-with-diurnal-preference-and-rotating-shift-work-in-japanese-female-nurses-a-cross-sectional-study
#3
Takahiro Yoshizaki, Yukari Kawano, Osamu Noguchi, Junko Onishi, Reiko Teramoto, Ayaka Sunami, Yuri Yokoyama, Yuki Tada, Azumi Hida, Fumiharu Togo
OBJECTIVES: Our study examines differences in eating behaviour between day workers and rotating shift workers, and considers whether diurnal preference could explain the differences. METHODS: Japanese female nurses were studied (39 day workers and 123 rotating shift workers, aged 21-63 years) using self-administered questionnaires. The questionnaires assessed eating behaviours, diurnal preference and demographic characteristics. The questionnaire in the Guidelines for the management of obesity disease issued by the Japan Society for the Study of Obesity was used to obtain scores for the levels of obesity-related eating behaviours, including cognition of constitution, motivation for eating, eating as a diversion, feeling of satiety, eating style, meal contents and temporal eating patterns...
November 28, 2016: BMJ Open
https://www.readbyqxmd.com/read/27894266/tuberculosis-drug-resistance-in-bamako-mali-from-2006-to-2014
#4
B Diarra, D Goita, S Tounkara, M Sanogo, B Baya, A C G Togo, M Maiga, Y S Sarro, A Kone, B Kone, O M'Baye, N Coulibaly, H Kassambara, A Cisse, M Belson, M A Polis, J Otu, F Gehre, M Antonio, S Dao, S Siddiqui, R L Murphy, B C de Jong, S Diallo
BACKGROUND: Although Drug resistance tuberculosis is not a new phenomenon, Mali remains one of the "blank" countries without systematic data. METHODS: Between 2006 and 2014, we enrolled pulmonary TB patients from local TB diagnostics centers and a university referral hospital in several observational cohort studies. These consecutive patients had first line drug susceptibility testing (DST) performed on their isolates. A subset of MDR was subsequently tested for second line drug resistance...
November 28, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27879498/enhancement-of-death-receptor-4-mediated-apoptosis-and-cytotoxicity-in-renal-cell-carcinoma-cells-by-anisomycin
#5
Yongnan Li, Xiuxian Wu, Xinghua Jin, Jiumei Wang, Yoshikazu Togo, Toru Suzuki, Takahiko Hashimoto, Yusuke Yamada, Yukako Nakanishi, Akihiro Kanematsu, Michio Nojima, Yoshiyuki Kakehi, Shingo Yamamoto
Renal cell carcinoma (RCC) is one of the most drug-resistant malignancies, and an effective therapy is lacking for metastatic RCC. Anisomycin is known to inhibit protein synthesis and induce ribotoxic stress. The aim of this study was to explore whether anisomycin enhances the cytotoxic effects of mapatumumab, a human agonistic monoclonal antibody specific for death receptor 4 (DR4), in human RCC cells. We examined the cytotoxicity of anisomycin alone and in combination with mapatumumab in human RCC cell lines and primary RCC cell cultures...
November 22, 2016: Anti-cancer Drugs
https://www.readbyqxmd.com/read/27879062/preparation-of-heteroaromatic-aryl-iodonium-imides-as-i-n-bond-containing-hypervalent-iodine
#6
Kazuma Ishida, Hideo Togo, Katsuhiko Moriyama
Hypervalent iodine(III) compounds containing iodine-nitrogen bonds are very attractive amination reagents in organic synthesis. Heteroaromatic (aryl)iodonium imides containing a iodine-nitrogen bond and a hypervalent iodine(III) atom were prepared from heteroarenes, bis(sulfon)imides and (diacetoxyiodo)arenes under mild conditions. These compounds were stable under air and in organic solvents, and could be easily purified by precipitation. X-ray crystal structure analysis indicated that the structure of N-pivaloyl indolyl(phenyl)iodonium bis(tosyl)imides and N-pivaloyl indolyl(2-butoxyphenyl)iodonium bis(tosyl)imides was a dimer with a T-shaped geometry at the iodine atom linked to an indole group and a bis(tosyl)imide by a monomer unit...
November 23, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27869225/noisy-galvanic-vestibular-stimulation-induces-a-sustained-improvement-in-body-balance-in-elderly-adults
#7
Chisato Fujimoto, Yoshiharu Yamamoto, Teru Kamogashira, Makoto Kinoshita, Naoya Egami, Yukari Uemura, Fumiharu Togo, Tatsuya Yamasoba, Shinichi Iwasaki
Vestibular dysfunction causes postural instability, which is prevalent in the elderly. We previously showed that an imperceptible level of noisy galvanic vestibular stimulation (nGVS) can improve postural stability in patients with bilateral vestibulopathy during the stimulus, presumably by enhancing vestibular information processing. In this study, we investigated the after-effects of an imperceptible long-duration nGVS on body balance in elderly adults. Thirty elderly participants underwent two nGVS sessions in a randomised order...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27865870/african-and-classical-swine-fever-situation-in-ivory-coast-and-neighboring-countries-2008-2013
#8
K V Kouakou, V Michaud, H G Biego, H P G Gnabro, A V Kouakou, A M Mossoun, J A Awuni, G L Minoungou, G L Aplogan, F K Awoumé, E Albina, R Lancelot, E Couacy-Hymann
This study was conducted from 2008 to 2013 to determine the animal health status of Ivory Coast and neighboring countries (Burkina Faso, Ghana, Togo and Benin) for African swine fever (ASF) and classical swine fever (CSF), and to assess the risk factors for ASF introduction in Ivory Coast. Ivory Coast had probably been free from ASF from 1998 to 2014 when it was re-introduced in this country. However, the ASF virus was found in all neighboring countries. In contrast, no evidence of CSF infection was found so far in Ivory Coast and neighboring countries...
November 16, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27852346/evaluation-of-chest-radiography-lyta-real-time-pcr-and-other-routine-tests-for-diagnosis-of-community-acquired-pneumonia-and-estimation-of-possible-attributable-fraction-of-pneumococcus-in-northern-togo
#9
A Blake, B M Njanpop-Lafourcade, J N Telles, A Rajoharison, M S Makawa, K Agbenoko, S Tamekloe, J E Mueller, H Tall, B D Gessner, G Paranhos-Baccalà, J C Moïsi
Streptococcus pneumoniae (Spn) is a leading cause of community-acquired pneumonia (CAP), yet existing diagnostic tools remain inadequate. We aimed to evaluate laboratory and radiological methods for detecting pneumococcal aetiology in CAP patients and to estimate Spn prevalence in this group. All-aged patients hospitalized with clinically defined CAP in northern Togo were enrolled during 2010-2013. Latent class analysis pooled results of semi-automated blood culture (SABC), whole blood lytA real-time polymerase chain reaction (rt-PCR), serum C-reactive protein (CRP), and chest radiography (CXR) and categorized patients as likely pneumococcal or non-pneumococcal CAP...
November 17, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27843013/-tuberculosis-among-chronic-hemodialysis-patients-in-togo-report-of-10%C3%A2-cases
#10
Mawufemo Yawovi Tsevi, Akomola Kossi Sabi, Laté Mawuli Lawson-Ananissoh, Befa Noto-Kadou-Kaza, Eyram Yoan Amekoudi
GOALS: To determine the frequency of tuberculosis among hemodialysis patients in Togo, specify its different localizations and identify its diagnostic and therapeutic difficulties. PATIENTS AND METHODS: This was a retrospective study over a period of 5 years (2010-2015). It includes the records of periodic hemodialysis patients in the Nephrology Department of the Sylvanus-Olympio University Teaching Hospital in Lomé. The diagnosis of tuberculosis was selected on the basis of clinical and laboratory data...
November 11, 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/27836088/indicators-of-availability-use-and-quality-of-emergency-obstetric-and-neonatal-care-in-togo-in-2012
#11
Adja Mariam Ouédraogo, Laeticia Ouédraogo/Nikiema, Ivlabèhiré Bertrand Meda, Kassouta N'Tapi, Seni Kouanda
OBJECTIVE: To assess the availability, utilization, and quality of emergency obstetric and neonatal care (EmONC) in Togo. METHODS: A cross-sectional study of EmONC services in all public and private health facilities in the territory of Togo conducted from July to December, 2012. The generic tools developed by the Averting Maternal Death and Disability program were used as the basic tools for this evaluation. RESULTS: The survey involved 1019 health facilities including 864 potential EmONC facilities that constituted the final sample...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27833394/two-cases-of-adenocarcinoma-occurring-in-sporadic-fundic-gland-polyps-observed-by-magnifying-endoscopy-with-narrow-band-imaging
#12
Kazumi Togo, Tetsuya Ueo, Hirotoshi Yonemasu, Hideho Honda, Tetsuya Ishida, Hiroshi Tanabe, Kenshi Yao, Akinori Iwashita, Kazunari Murakami
Gastric fundic gland polyps (FGPs) are common non-adenomatous gastric polyps arising from normal fundic mucosa without Helicobacter pylori (H. pylori) infection. Although systemic FGPs associated with familial adenomatous polyposis (FAP) often have dysplasia, there are few reports of dysplasia occurring in sporadic FGPs, especially when detected by magnifying endoscopy with narrow band imaging (ME-NBI). We experienced two cases of adenocarcinoma occurring in sporadic FGPs, and their ME-NBI findings were very useful for differentiating FGP with cancer from non-dysplastic FGP...
October 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27821092/human-meningitis-due-to-streptococcus-suis-in-lom%C3%A3-togo-a-case-report
#13
Mireille Prince-David, Mounerou Salou, Corinne Marois-Créhan, Komi Assogba, Céline Plainvert, Koffi A Balogou, Claire Poyart, Asmaa Tazi
BACKGROUND: Streptococcus suis is a zoonotic pathogen which represents the leading cause of meningitis in Southeast Asia and an emerging pathogen in the Western world, the main risk factor for infection being contact with pigs. In Africa, the prevalence of S. suis infections in swine and humans is largely unrecognized, with only one recent report of a limited case series. CASE PRESENTATION: We describe a human case of meningitis due to S. suis in a 32-year-old man living in Togo...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27819657/culture-of-previously-uncultured-members-of-the-human-gut-microbiota-by-culturomics
#14
Jean-Christophe Lagier, Saber Khelaifia, Maryam Tidjani Alou, Sokhna Ndongo, Niokhor Dione, Perrine Hugon, Aurelia Caputo, Frédéric Cadoret, Sory Ibrahima Traore, El Hadji Seck, Gregory Dubourg, Guillaume Durand, Gaël Mourembou, Elodie Guilhot, Amadou Togo, Sara Bellali, Dipankar Bachar, Nadim Cassir, Fadi Bittar, Jérémy Delerce, Morgane Mailhe, Davide Ricaboni, Melhem Bilen, Nicole Prisca Makaya Dangui Nieko, Ndeye Mery Dia Badiane, Camille Valles, Donia Mouelhi, Khoudia Diop, Matthieu Million, Didier Musso, Jônatas Abrahão, Esam Ibraheem Azhar, Fehmida Bibi, Muhammad Yasir, Aldiouma Diallo, Cheikh Sokhna, Felix Djossou, Véronique Vitton, Catherine Robert, Jean Marc Rolain, Bernard La Scola, Pierre-Edouard Fournier, Anthony Levasseur, Didier Raoult
Metagenomics revolutionized the understanding of the relations among the human microbiome, health and diseases, but generated a countless number of sequences that have not been assigned to a known microorganism(1). The pure culture of prokaryotes, neglected in recent decades, remains essential to elucidating the role of these organisms(2). We recently introduced microbial culturomics, a culturing approach that uses multiple culture conditions and matrix-assisted laser desorption/ionization-time of flight and 16S rRNA for identification(2)...
November 7, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27817852/-problematics-of-subarachnoid-hemorrhage-in-developing-countries-the-case-of-togo
#15
K M H Ahanogbe, M Belo, A K Beketi, S Kpelao, K A Doleagbenou
OBJECTIVE: To analyze the diagnostic and therapeutic strategies as well as the results of the treatment of spontaneous subarachnoid hemorrhage (SAH) in Togo, before creating a neurosurgery department. METHODS: We conducted a case series of subarachnoid hemorrhage collected from 30 June 2005 to 30 June 2010 in the Universities Hospital of Lomé. It involved patients older than 15 years of age hospitalized for subarachnoid hemorrhage with clinical and/or radiation confirmation...
December 2016: Neuro-Chirurgie
https://www.readbyqxmd.com/read/27806714/the-emerging-threat-of-pre-extensively-drug-resistant-tuberculosis-in-west-africa-preparing-for-large-scale-tuberculosis-research-and-drug-resistance-surveillance
#16
Florian Gehre, Jacob Otu, Lindsay Kendall, Audrey Forson, Awewura Kwara, Samuel Kudzawu, Aderemi O Kehinde, Oludele Adebiyi, Kayode Salako, Ignatius Baldeh, Aisha Jallow, Mamadou Jallow, Anoumou Dagnra, Kodjo Dissé, Essosimna A Kadanga, Emmanuel Oni Idigbe, Catherine Onubogu, Nneka Onyejepu, Aissatou Gaye-Diallo, Awa Ba-Diallo, Paulo Rabna, Morto Mane, Moumine Sanogo, Bassirou Diarra, Zingue Dezemon, Adama Sanou, Madikay Senghore, Brenda A Kwambana-Adams, Edward Demba, Tutty Faal-Jawara, Samrat Kumar, Leopold D Tientcheu, Adama Jallow, Samba Ceesay, Ifedayo Adetifa, Assan Jaye, Mark J Pallen, Umberto D'Alessandro, Beate Kampmann, Richard A Adegbola, Souleymane Mboup, Tumani Corrah, Bouke C de Jong, Martin Antonio
BACKGROUND: Drug-resistant tuberculosis (TB) is a global public health problem. Adequate management requires baseline drug-resistance prevalence data. In West Africa, due to a poor laboratory infrastructure and inadequate capacity, such data are scarce. Therefore, the true extent of drug-resistant TB was hitherto undetermined. In 2008, a new research network, the West African Network of Excellence for Tuberculosis, AIDS and Malaria (WANETAM), was founded, comprising nine study sites from eight West African countries (Burkina Faso, The Gambia, Ghana, Guinea-Bissau, Mali, Nigeria, Senegal and Togo)...
November 3, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27796315/three-dimensional-ultrastructural-analyses-of-anterior-pituitary-gland-expose-spatial-relationships-between-endocrine-cell-secretory-granule-localization-and-capillary-distribution
#17
Munetake Yoshitomi, Keisuke Ohta, Tomonoshin Kanazawa, Akinobu Togo, Shingo Hirashima, Kei-Ichiro Uemura, Satoko Okayama, Motohiro Morioka, Kei-Ichiro Nakamura
Endocrine and endothelial cells of the anterior pituitary gland frequently make close appositions or contacts, and the secretory granules of each endocrine cell tend to accumulate at the perivascular regions, which is generally considered to facilitate secretory functions of these cells. However, three-dimensional relationships between the localization pattern of secretory granules and blood vessels are not fully understood. To define and characterize these spatial relationships, we used scanning electron microscopy (SEM) three-dimensional reconstruction method based on focused ion-beam slicing and scanning electron microscopy (FIB/SEM)...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27788172/retrospective-review-of-the-anaesthetic-management-of-maxillectomies-and-mandibulectomies-for-benign-tumours-in-sub-saharan-africa
#18
Michelle C White, Katherine C Horner, Peggy S Lai
BACKGROUND: Safe anaesthesia is a crucial component of safe surgical care, yet anaesthetic complications are common in resource-limited settings. We describe differences in anaesthetic needs for Mandibulectomy vs. Maxillectomy in three sub-Saharan African countries. MATERIALS AND METHODS: Retrospective review of patients undergoing minor Mandibulectomy, major Mandibulectomy, or Maxillectomy in Togo, Guinea and Republic of the Congo. Surgeries were performed on the Africa Mercy, an international non-governmental hospital ship...
2016: PloS One
https://www.readbyqxmd.com/read/27776188/analysis-of-macular-drusen-and-blood-test-results-in-945-macaca-fascicularis
#19
Koji M Nishiguchi, Yu Yokoyama, Yusuke Fujii, Kosuke Fujita, Yusuke Tomiyama, Ryo Kawasaki, Toshinori Furukawa, Fumiko Ono, Nobuhiro Shimozawa, Mutsumi Togo, Michihiro Suzuki, Toru Nakazawa
Age-dependent formation of macular drusen caused by the focal accumulation of extracellular deposits beneath the retinal pigment epithelium precede the development of age-related macular degeneration (AMD), one of the leading causes of blindness worldwide. It is established that inflammation contributes to the pathogenesis of drusen and AMD. However, development of a preemptive therapeutic strategy targeting macular drusen and AMD has been impeded by the lack of relevant animal models because most laboratory animals lack macula, an anatomic feature present only in humans and a subset of monkeys...
2016: PloS One
https://www.readbyqxmd.com/read/27752323/-ruminococcus-phoceensis-a-new-species-identified-from-human-stool-from-an-obese-patient-before-bariatric-surgery
#20
A H Togo, M Maraninchi, F Bittar, D Raoult, M Million
We report here the main characteristics of a new bacterium species, "Ruminococcus phoceensis" strain AT10 (CSUR = P2086, DSM = 100837). This bacterium was isolated from the faeces of a 37-year-old woman from Marseille, France, with morbid obesity before bariatric surgery.
November 2016: New Microbes and New Infections
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