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https://www.readbyqxmd.com/read/28432274/sensitive-detection-of-viable-circulating-tumor-cells-using-a-novel-conditionally-telomerase-selective-replicating-adenovirus-in-non-small-cell-lung-cancer-patients
#1
Shinsaku Togo, Nobuyoshi Katagiri, Yukiko Namba, Miniwan Tulafu, Kumi Nagahama, Kotarou Kadoya, Kazuya Takamochi, Siaki Oh, Kenji Suzuki, Fuminori Sakurai, Hiroyuki Mizuguchi, Yasuo Urata, Kazuhisa Takahashi
Circulating tumor cells (CTCs) have a crucial role in the clinical outcome of cancer patients. Detection of non-small cell lung cancer (NSCLC) using an antibody against epithelial cell adhesion molecule (EpCAM) in captured CTCs has low sensitivity; the loss of epithelial markers leads to underestimation of CTCs with mesenchymal phenotype. We propose a new approach for detection of viable CTCs, including those with epithelial-mesenchymal transition status (EMT-CTCs), using the new telomerase-specific replication-selective adenovirus (OBP-1101), TelomeScan F35...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422447/lc-ms-ms-and-chiroptical-spectroscopic-analyses-of-multidimensional-metabolic-systems-of-chiral-thalidomide-and-its-derivatives
#2
Yoshiyuki Ogino, Masahito Tanaka, Togo Shimozawa, Toru Asahi
Enantiomeric thalidomide undergoes various kinds of biotransformations including chiral inversion, hydrolysis, and enzymatic oxidation, which results in several metabolites, thereby adding to the complexity in the understanding of the nature of thalidomide. To decipher this complexity, we analyzed the multidimensional metabolic reaction networks of thalidomide and related molecules in vitro. Characteristic patterns in the amount of various metabolites of thalidomide and related molecules generated during a combination of chiral inversion, hydrolysis, and hydroxylation were observed using liquid chromatography-tandem mass spectrometry and chiroptical spectroscopy...
April 19, 2017: Chirality
https://www.readbyqxmd.com/read/28420428/significant-heterogeneity-in-wolbachia-copy-number-within-and-between-populations-of-onchocerca-volvulus
#3
Samuel Armoo, Stephen R Doyle, Mike Y Osei-Atweneboana, Warwick N Grant
BACKGROUND: Wolbachia are intracellular bacteria found in arthropods and several filarial nematode species. The filarial Wolbachia have been proposed to be involved in the immunopathology associated with onchocerciasis. Higher Wolbachia-to-nematode ratios have been reported in the savannah-ecotype compared to the forest-ecotype, and have been interpreted as consistent with a correlation between Wolbachia density and disease severity. However, factors such as geographic stratification and ivermectin drug exposure can lead to significant genetic heterogeneity in the nematode host populations, so we investigated whether Wolbachia copy number variation is also associated with these underlying factors...
April 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28392456/anti-inflammatory-activity-of-crateva-adansonii-dc-on-keratinocytes-infected-by-staphylococcus-aureus-from-traditional-practice-to-scientific-approach-using-hptlc-densitometry
#4
Kplolali Ahama-Esseh, Charles Bodet, Akossiwa Quashie-Mensah-Attoh, Magali Garcia, Isabelle Théry-Koné, Joelle Dorat, Comlan De Souza, Cécile Enguehard-Gueiffier, Leslie Boudesocque-Delaye
ETHNOPHARMACOLIGICAL RELEVANCE: Leaves of Crateva adansonii DC (Capparidaceae), a small bush found in Togo, are widely used in traditional medicine to cure infectious abscesses. Traditional healers of Lomé harvest only budding leaves early in the morning, in specific area in order to prepare their drugs. AIM OF THE STUDY: The main goal was to validate the ancestral picking practices, and to assess the activity of C. adansonii medicine towards infectious abscesses...
April 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28362065/alcohol-use-viral-hepatitis-and-liver-fibrosis-among-hiv-positive-persons-in-west-africa-a-cross-sectional-study
#5
Antoine Jaquet, Gilles Wandeler, Marcellin Nouaman, Didier K Ekouevi, Judicaël Tine, Akouda Patassi, Patrick A Coffie, Aristophane Tanon, Moussa Seydi, Alain Attia, François Dabis
INTRODUCTION: Liver fibrosis is often the first stage of liver disease in people living with HIV (PLWHIV) in industrialized countries. However, little is known about liver fibrosis and its correlates among PLWHIV in sub-Saharan Africa. METHODS: The study was undertaken in three HIV referral clinics in Côte d'Ivoire, Senegal and Togo. Enrolled PLWHIV underwent a non-invasive assessment of liver fibrosis combining liver stiffness measure (LSM) with transient elastography and the aspartate aminotransferase-to-platelet ratio index (APRI)...
February 17, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28361888/control-strategy-of-hand-movement-depends-on-target-redundancy
#6
Shunta Togo, Toshinori Yoshioka, Hiroshi Imamizu
Reaching toward a point target has been intensively studied in human motor control. However, little is known about reaching toward a redundant target, such as grasping a bar, in which the grasping point is irrelevant to the achievement of a task. We examined whether humans could solve the target-redundancy and control problems in a serial fashion or control their body without solving the target-redundancy problem. We equalized the target ranges between two reaching tasks: a point-to-point reaching task without target-redundancy and a point-to-bar reaching task with target-redundancy...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345835/evolution-of-the-histo-epidemiological-profile-of-urological-cancers-in-togo
#7
Tchin Darré, Koué Folligan, Tchilabalo Matchonna Kpatcha, Kokou Kanassoua, Edoe Sewa, Sassil Daré, Kodjo Tengue, Koffi Amégbor, Gado Napo Koura
Background: Urological cancers are an important public health issue and pose problems with diagnosis and adequate management in developing countries. Our aim was to determine and report epidemiological and histological features of urological cancers in Togo. Materials and methods: A retrospective descriptive study was conducted of cases of urological cancers observed in the laboratory of pathological anatomy of the CHU Tokoin over the last 4 years (2012-2016). The parameters studied were frequency, age, sex, sites of development and histological type...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28327374/discovery-and-molecular-interaction-studies-of-a-highly-stable-tarantula-peptide-modulator-of-acid-sensing-ion-channel-1
#8
REVIEW
Sing Yan Er, Ben Cristofori-Armstrong, Pierre Escoubas, Lachlan D Rash
Acute pharmacological inhibition of acid-sensing ion channel 1a (ASIC1a) is efficacious in rodent models in alleviating symptoms of neurological diseases such as stroke and multiple sclerosis. Thus, ASIC1a is a promising therapeutic target and selective ligands that modulate it are invaluable research tools and potential therapeutic leads. Spider venoms have provided an abundance of voltage-gated ion channel modulators, however, only one ASIC modulator (PcTx1) has so far been isolated from this source. Here we report the discovery, characterization, and chemical stability of a second spider venom peptide that potently modulates ASIC1a and ASIC1b, and investigate the molecular basis for its subtype selectivity...
March 18, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28326685/hugonella-massiliensis-gen-nov-sp-nov-genome-sequence-and-description-of-a-new-strictly-anaerobic-bacterium-isolated-from-the-human-gut
#9
Ziena Elsawi, Amadou Hamidou Togo, Mamadou Beye, Grégory Dubourg, Claudia Andrieu, Nicholas Armsrtong, Magali Richez, Fabrizio di Pinto, Fadi Bittar, Noémie Labas, Pierre-Edouard Fournier, Didier Raoult, Saber Khelaifia
The human gut is composed of a large diversity of microorganisms, which have been poorly described. Here, using culturomics, a new concept based on the variation in culture conditions and MALDI-TOF MS identification, we proceed to explore the microbial diversity of the complex ecosystem of the human gut. Using this approach, we isolated strain AT8(T) (=CSUR P2118 =  DSM 101782) from stool specimens collected from a 51-year-old obese French woman. Strain AT8(T) is a strictly anaerobic, nonmotile, nonspore-forming gram-positive coccus that do not exhibit catalase and oxidase activities...
March 21, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28301539/identifying-inequities-in-maternal-and-child-health-through-risk-stratification-to-inform-health-systems-strengthening-in-northern-togo
#10
Katharine J McCarthy, Sandra Braganza, Kevin Fiori, Christophe Gbeleou, Vivien Kpakpo, Andrew Lopez, Jennifer Schechter, Alicia Singham Goodwin, Heidi E Jones
OBJECTIVE: In Togo, substantial progress in maternal and child health is needed to reach global development goals. To better inform clinic and community-based health services, this study identifies factors associated with maternal and child health care utilization in the Kara region of Northern Togo. METHODS: We conducted a population-representative household survey of four health clinic catchment areas of 1,075 women of reproductive age in 2015. Multivariable logistic regression was used to model individual and structural factors associated with utilization of four maternal and child health services...
2017: PloS One
https://www.readbyqxmd.com/read/28288771/cattle-breeding-trypanosomosis-prevalence-and-drug-resistance-in-northern-togo
#11
E Tchamdja, A E Kulo, H S Vitouley, K Batawui, A A Bankolé, K Adomefa, G Cecchi, A Hoppenheit, P H Clausen, R De Deken, J Van Den Abbeele, T Marcotty, V Delespaux
African Animal Trypanosomosis (AAT) is a major disease of cattle in Togo and its control is essentially based on chemotherapy. However, because of excessive use of trypanocides during the past decades, chemo-resistance in the parasites has developed. In order to assess the current situation of AAT and resistance to trypanocidal drugs in Northern Togo, a study was conducted on cattle from December 2012 to August 2013 in the regions of Kara and Savanes. An initial cross-sectional survey was carried out in 40 villages using the Haematocrit Centrifugation Technique (HCT)...
March 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28284212/combination-of-glycopyrronium-and-indacaterol-inhibits-carbachol-induced-erk5-signal-in-fibrotic-processes
#12
Yukiko Namba, Shinsaku Togo, Miniwan Tulafu, Kotaro Kadoya, Kumi Yoneda Nagahama, Hikari Taka, Naoko Kaga, Akira Orimo, Xiangde Liu, Kazuhisa Takahashi
BACKGROUND: Airway fibrosis is one of the pathological features of chronic obstructive pulmonary disease (COPD), and recent studies revealed that acetylcholine plays an important role in the development of airway remodeling by stimulating proliferation and collagen synthesis of lung fibroblasts. This study was designed to examine the effects of a long-acting muscarinic receptor antagonist (LAMA) glycopyrronium and a long-acting β2 adrenergic receptor agonist (LABA) indacaterol on acetylcholine-mediated fibrotic responses in lung fibroblasts...
March 11, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28283710/clinical-and-urodynamic-assessment-in-patients-with-pelvic-organ-prolapse-before-and-after-laparoscopic-sacrocolpopexy
#13
Bahiyah Abdullah, Jimmy Nomura, Shingo Moriyama, Tingwen Huang, Shino Tokiwa, Mio Togo
INTRODUCTION AND HYPOTHESIS: We hypothesized that patient-reported urinary symptoms and urodynamic evaluation improve after laparoscopic sacrocolpopexy (LSC) despite deeper vesicovaginal space dissection. METHODS: This was a retrospective study of women with pelvic organ prolapse who underwent LSC from January 2013 to January 2016 in a tertiary center. Urinary function was clinically evaluated using the International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF), the Overactive Bladder Symptom Score (OABSS) and the Pelvic Floor Distress Inventory Questionnaire- - Short Form 20 (PFDI-20)...
March 10, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28277271/change-over-time-in-parents-beliefs-about-and-reported-use-of-corporal-punishment-in-eight-countries-with-and-without-legal-bans
#14
Jennifer E Lansford, Claudia Cappa, Diane L Putnick, Marc H Bornstein, Kirby Deater-Deckard, Robert H Bradley
Stopping violence against children is prioritized in goal 16 of the Sustainable Development Goals adopted by the United Nations General Assembly in 2015. All forms of child corporal punishment have been outlawed in 50 countries as of October 2016. Using data from 56,371 caregivers in eight countries that participated in UNICEF's Multiple Indicator Cluster Survey, we examined change from Time 1 (2005-6) to Time 2 (2008-13) in national rates of corporal punishment of 2- to 14-year-old children and in caregivers' beliefs regarding the necessity of using corporal punishment...
October 27, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28268157/orbicularis-oculi-muscle-tightening-for-involutional-entropion
#15
Hitoshi Nemoto, Tomoichiro Togo, Naoki Maruyama, Kenta Miyabe, Seiko Nakae, Noriyoshi Sumiya
AIMS: To describe a novel technique for involutional entropion (IE) correction and present a retrospective case study. PATIENTS AND METHODS: The entropion eyelid was corrected by repairing the thin preseptal orbicularis oculi muscle (OOM) of the lower eyelid. Patients underwent correction with this method from 2005 to 2014 and were followed up for 2 years postoperatively. They were evaluated retrospectively with chart review (operation time, recurrence rate, operator years of experience as a plastic surgeon, etc...
February 17, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28264832/retrospective-review-of-surgical-availability-and-readiness-in-8-african-countries
#16
D A Spiegel, B Droti, P Relan, S Hobson, M N Cherian, K O'Neill
OBJECTIVES: The purpose of this study was to assess surgical availability and readiness in 8 African countries using the WHO's Service Availability and Readiness Assessment (SARA) tool. SETTING: We analysed data for surgical services, including basic and comprehensive surgery, comprehensive obstetric care, blood transfusion, and infection prevention, obtained from the WHO's SARA surveys in Sierra Leone, Uganda, Mauritania, Benin, Zambia, Burkina Faso, Democratic Republic of Congo and Togo...
March 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28222772/prevalence-of-syphilis-among-female-sex-workers-and-their-clients-in-togo-in-2011
#17
Wemboo Afiwa Halatoko, Dadja Essoya Landoh, Bayaki Saka, Koffi Akolly, Yao Layibo, Issifou Yaya, Dodji Gbetoglo, Abiba Kere Banla, Palokinam Pitché
BACKGROUND: During the last ten years, a resurgence of syphilis has occurred in many countries worldwide, including Togo. Previous studies have shown a wide range of syphilis infection among the female sex workers (FSWs), from 1.5 to 42.1%. In Togo, Key populations, including FSWs, are rarely involved in the sentinel surveillance programs to determine the prevalence of HIV and syphilis. The aim of this study was to determine the prevalence of syphilis among female sex workers (FSWs) and their clients in Togo...
February 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28217435/a-rare-fungal-infection-phaehyphomycosis-due-to-veronaea-botryosa-and-review-of-literature
#18
Anne Welfringer, Valérie Vuong, Nicolas Argy, Christian Chochillon, Lydia Deschamps, Guillaume Rollin, Stanislas Harent, Véronique Joly, William Vindrios, Vincent Descamps
We report a rare case of phaehyphomycosis in a 71-year-old heart transplant recipient Togo native patient. Four months after the transplant, he presented painless nodules on the right heel with superficial ulceration. The polyphasic identification uncovered a rare cause of phaehyphomycose: V. botryosa. The treatment combined surgical excision of the lesions and anti-fungal therapy with posaconazole. We discussed eleven reported cases in literature since 1990.
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28217218/high-prevalence-of-hepatitis-b-virus-infection-in-the-age-range-of-20-39-years-old-individuals-in-lome
#19
Malewe Kolou, Gnatoulma Katawa, Mounerou Salou, Komlan Selom Gozo-Akakpo, Sika Dossim, Alexander Kwarteng, Mireille Prince-David
BACKGROUND: Hepatitis B is a liver infection caused by the hepatitis B virus (HBV). It affects all women and men irrespective of age. Although sub-Saharan Africa is an area of high prevalence of this disease, data on the prevalence of acute and chronic HBV infections in this region remain to be widely documented. OBJECTIVE: This study aimed to investigate the prevalence of HBV in relation to age in Centre Hospitalier Universitaire Campus (CHU-C), one of the two teaching hospitals of Lome, Togo...
2017: Open Virology Journal
https://www.readbyqxmd.com/read/28217106/effect-of-noisy-galvanic-vestibular-stimulation-on-ocular-vestibular-evoked-myogenic-potentials-to-bone-conducted-vibration
#20
Shinichi Iwasaki, Shotaro Karino, Teru Kamogashira, Fumiharu Togo, Chisato Fujimoto, Yoshiharu Yamamoto, Tatsuya Yamasoba
OBJECTIVE: Galvanic vestibular stimulation (GVS) delivered as zero-mean current noise (noisy GVS) has been shown to improve static and dynamic postural stability probably by enhancing vestibular information. The purpose of this study was to examine the effect of an imperceptible level noisy GVS on ocular vestibular-evoked myogenic potentials (oVEMPs) in response to bone-conducted vibration (BCV). MATERIALS AND METHODS: oVEMPs to BCV were measured during the application of white noise GVS with an amplitude ranging from 0 to 300 µA [in root mean square (RMS)] in 20 healthy subjects...
2017: Frontiers in Neurology
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