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A H Togo, M Maraninchi, F Bittar, D Raoult, M Million
We report here the main characteristics of a new bacterium species, "Ruminococcus phoceensis" strain AT10 (CSUR = P2086, DSM = 100837). This bacterium was isolated from the faeces of a 37-year-old woman from Marseille, France, with morbid obesity before bariatric surgery.
November 2016: New Microbes and New Infections
Samuel B Pattle, Natasa Utjesanovic, Athena Togo, Lucy Wells, Brendan Conn, Hannah Monaghan, Elizabeth Junor, Ingolfur Johannessen, Kate Cuschieri, Simon Talbot
Squamous cell carcinomas of the hypopharynx (HPSCC) and oropharynx (OPSCC) have markedly different patient outcomes. Differences in HPV prevalence between these two patient groups may account for some of this difference, but other molecular markers of prognosis or pathological phenotype have not been established. Copy number gain of oncogenes is a well-established molecular change contributing to HNSCC development. Quantitative PCR was used to explore copy number gains of specific genes (3q - PIK3CA, TP63; 11q13...
October 17, 2016: Genes, Chromosomes & Cancer
Bassirou Diarra, David Safronetz, Yeya Dit Sadio Sarro, Amadou Kone, Moumine Sanogo, Sady Tounkara, Antieme C G Togo, Fatoumata Daou, Almoustapha I Maiga, Sounkalo Dao, Kyle Rosenke, Darryl Falzarano, Seydou Doumbia, Kathryn C Zoon, Michael Polis, Sophia Siddiqui, Samba Sow, Tom G Schwan, Heinz Feldmann, Souleyman Diallo, Ousmane A Koita
Aware of the rapid spread of Ebola virus (EBOV) during the current West African epidemic, Mali took several proactive steps to rapidly identify cases within its borders. Under the Mali International Center for Excellence in Research program, a collaboration between the National Institute of Allergy and Infectious Diseases and the Malian Ministry of Higher Education and Scientific Research established a national EBOV diagnostic site at the University of Sciences, Techniques and Technologies of Bamako in the SEREFO Laboratory...
October 15, 2016: Journal of Infectious Diseases
A H Togo, R Valero, J Delerce, D Raoult, M Million
We report the main characteristics of a new bacterial species strain AT3(T) (CSUR = P2007, DSM = 100567) that was isolated from the stool sample collected from a 47-year-old obese French man after he underwent bariatric surgery.
November 2016: New Microbes and New Infections
D Tchin, W Atsi, T Hodabalo Tchaa, Kpelao Essossinam, J Yaovii Edèm, K Koffi Amégbor, N-K Gado
We collected 190 forensic records from the only pathology laboratory in Lomé, over the period from January 2010 to December 2014. The sex ratio (M/F) was 4.4 and the decedents' average age 33.4 years. In 43.2% of cases, the accident resulted from a collision between a pedestrian and a motorcycle; excess speed noted in 56.8% of cases. Four principal groups of fatal injuries were observed: polytrauma (136 cases), isolated severe head injury (49 cases), isolated thoracic contusion (3 cases), and abdominal pelvic contusion with perinea trauma (2 cases)...
August 1, 2016: Médecine et Santé Tropicales
K A R Segbedji, K E Djadou, O-B Tchagbele, M Kpegouni, L K Bessi Kama, K D Azoumah, A D Agbèrè
INTRODUCTION: Tuberculosis (TB) remains one of the most lethal communicable diseases in the world, according to the World Health Organization (WHO). New strategies must be implemented to meet targets for 2035. OBJECTIVE: Describe the epidemiological and therapeutic aspects of tuberculosis in children in Togo. MATERIALS AND METHODS: This retrospective, multicenter, descriptive cross-sectional study examined the files of children younger than 15 years who were diagnosed with TB and treatment in the Maritime region from 2008 to 2011...
August 1, 2016: Médecine et Santé Tropicales
K Vonor, K M Amedome, K Dzidzinyo, K Koutolbena, M Banla, K P Balo
To assess the prevalence of senile cataracts and the awareness and attitudes of patients with them in a rural area in Togo. We conducted a 10-weeks cross-sectional ophthalmic screening in the prefecture of VO, 57 km from Lomé, which sought to include individuals aged 50 years and older living in the study area. All patients underwent a comprehensive ophthalmic examination. Of the 3111 patients expected, 767 came for the examination, for a participation rate of 24.6%. The sex ratio was 0.8, and the patients' mean age was 60...
August 1, 2016: Médecine et Santé Tropicales
Stembile Mugore, Ntapi Tchiguiri K Kassouta, Boniface Sebikali, Laurel Lundstrom, Abdulmumin Saad
High-quality postabortion care (PAC) services that include family planning counseling and a full range of contraceptives at point of treatment for abortion complications have great potential to break the cycle of repeat unintended pregnancies and demand for abortions. We describe the first application of a systematic approach to quality improvement of PAC services in a West African country. This approach-IntraHealth International's Optimizing Performance and Quality (OPQ) approach-was applied at 5 health care facilities in Togo starting in November 2014...
September 28, 2016: Global Health, Science and Practice
Katsuhiko Moriyama, Masako Kuramochi, Kozo Fujii, Tsuyoshi Morita, Hideo Togo
A nitroxyl-radical-catalyzed oxidative coupling reaction between amines with an N-protecting electron-withdrawing group (EWG) and silylated nucleophiles was developed to furnish coupling products in high yields, thus opening up new frontiers in organocatalyzed reactions. This reaction proceeded through the activation of N-halogenated amides by a nitroxyl-radical catalyst, followed by carbon-carbon coupling with silylated nucleophiles. Studies of the reaction mechanism indicated that the nitroxyl radical activates N-halogenated amides, which are generated from N-EWG-protected amides and a halogenation reagent, to give the corresponding imines...
September 29, 2016: Angewandte Chemie
Seiichi Tsukamoto, Teruyuki Fujii, Kotaro Oyama, Seine A Shintani, Togo Shimozawa, Fuyu Kobirumaki-Shimozawa, Shin'ichi Ishiwata, Norio Fukuda
In cardiac muscle, contraction is triggered by sarcolemmal depolarization, resulting in an intracellular Ca(2+) transient, binding of Ca(2+) to troponin, and subsequent cross-bridge formation (excitation-contraction [EC] coupling). Here, we develop a novel experimental system for simultaneous nano-imaging of intracellular Ca(2+) dynamics and single sarcomere length (SL) in rat neonatal cardiomyocytes. We achieve this by expressing a fluorescence resonance energy transfer (FRET)-based Ca(2+) sensor yellow Cameleon-Nano (YC-Nano) fused to α-actinin in order to localize to the Z disks...
October 2016: Journal of General Physiology
A H Togo, A Diop, G Dubourg, T T Nguyen, C Andrieu, A Caputo, C Couderc, P-E Fournier, M Maraninchi, R Valero, D Raoult, M Million
Butyricimonas phoceensis strain AT9 (= CSUR 1981 = DSM 100664) was isolated from a stool sample from a morbidly obese French patient living in Marseille using the culturomics approach. The genome of this Gram-negative-staining, anaerobic and non-spore forming rod bacillus is 4 736 949 bp long and contains 3947 protein-coding genes. Genomic analysis identified 173 genes as ORFans (4.5%) and 1650 orthologous proteins (42%) not shared with the closest phylogenetic species, Butyricimonas virosa. Its major fatty acid was the branched acid iso-C15:0 (62...
November 2016: New Microbes and New Infections
Togo Shimozawa, Erisa Hirokawa, Fuyu Kobirumaki-Shimozawa, Kotaro Oyama, Seine A Shintani, Takako Terui, Yasuharu Kushida, Seiichi Tsukamoto, Teruyuki Fujii, Shin'ichi Ishiwata, Norio Fukuda
The cardiac pump function is a result of a rise in intracellular Ca(2+) and the ensuing sarcomeric contractions [i.e., excitation-contraction (EC) coupling] in myocytes in various locations of the heart. In order to elucidate the heart's mechanical properties under various settings, cardiac imaging is widely performed in today's clinical as well as experimental cardiology by using echocardiogram, magnetic resonance imaging and computed tomography. However, because these common techniques detect local myocardial movements at a spatial resolution of ∼100 μm, our knowledge on the sub-cellular mechanisms of the physiology and pathophysiology of the heart in vivo is limited...
September 21, 2016: Progress in Biophysics and Molecular Biology
Vonor Kokou, Maneh Nidain, Nononsaa Batomguela Kassoula, Fiaty-Amenouvor Kwassi, Banla Meba, Balo Komi Patrice
INTRODUCTION: Describe the epidemiology of neonatal conjunctivitis in the Canton of Glidji in southern Togo. METHODS: We conducted a cross-sectional study in 4 Satellite Health Care Units in the Canton of Glidji from 19 March to 13 May 2009 (8 weeks). All newborns were included in the study and neonatal conjunctivitis was defined by the presence in a newborn of at least two of the following signs: conjunctival hyperemia, eyelid swelling, chemosis, purulent discharges, lacrimation...
2016: Pan African Medical Journal
Dadja Essoya Landoh, Farihétou Ouro-Kavalah, Issifou Yaya, Anna-Lea Kahn, Peter Wasswa, Anani Lacle, Danladi Ibrahim Nassoury, Sheba Nakacubo Gitta, Abdramane Bassiahi Soura
BACKGROUND: Incompleteness of vaccination coverage among children is a major public health concern because itcontinues to sustain a high prevalence of vaccine-preventable diseases in some countries. In Togo, very few data on the factors associated with incomplete vaccination coverage among children have been published. We determined the prevalence of incomplete immunization coverage in children aged one to five years in Togo and associated factors. METHODS: This was a cross-sectional study using secondary data from the 2010 Multiple Indicator Cluster Surveys (MICS4) conducted in 2010 among children aged 1 to 5 years in Togo...
2016: BMC Public Health
Lonzozou Kpanake, Sadji Gbandey, Paul Clay Sorum, Etienne Mullet
In anticipation of a future HIV vaccine, we mapped the different personal positions regarding HIV vaccination of people in Togo. In early 2014, 363 adults indicated their willingness to receive a future HIV vaccine under different conditions varying as a function of five factors: perceived susceptibility to HIV, vaccine effectiveness, perceived severity of AIDS, vaccine cost, and family's influence. We found five qualitatively different positions: unconditional acceptance (49%), depends on cost/effectiveness ratio (20%), depends on cost (18%), total indecision (10%), and complete reluctance (3%)...
March 31, 2016: Journal of Health Psychology
Tomohide Kubo, Masaya Takahashi, Xinxin Liu, Hiroki Ikeda, Fumiharu Togo, Akihito Shimazu, Katsutoshi Tanaka, Naoki Kamata, Yoshiko Kubo, Junko Uesugi
OBJECTIVES: This observational study aimed to determine how 1-year changes in work time control (WTC) have an impact upon objectively measured fatigue and sleep among employees. METHODS: Thirty-nine employees were divided into two groups according to whether or not their WTC increased from baseline to 1 year later. Psychomotor vigilance task (PVT) and wrist actigraphy were used to objectively measure fatigue and sleep, respectively. Self-reported outcomes were also measured...
September 6, 2016: Journal of Occupational and Environmental Medicine
Sunao Takahashi, Togo Kudo, Mutsumi Sano, Atsuo Watanabe, Hiroo Tajiri
A new beam profile monitoring system for the small X-ray beam exiting from the SPring-8 front-end was developed and tested at BL13XU. This system is intended as a screen monitor and also as a position monitor even at beam currents of 100 mA by using photoluminescence of a chemical vapor deposition-grown diamond film. To cope with the challenge that the spatial distribution of the photoluminescence in the vertical direction is too flat to detect the beam centroid within a limited narrow aperture, a filter was installed that absorbs the fundamental harmonic concentrated in the beam center, which resulted in "de-flattening" of the vertical distribution...
August 2016: Review of Scientific Instruments
Matshidiso Moeti
INTRODUCTION: Recently we have recorded some progress against the transmission of poliovirus in the African Region. This is attributable to a number of factors, including commitment of global partnerships against polio, improvement of existing strategies as well as a number of innovations in response to the disease in the Region. METHODS: The WHO Regional Office in Africa documented these practices that led to the noticeable progress in the polio eradication initiative in the African Region, as lessons learnt and as part of polio legacy planning...
October 10, 2016: Vaccine
Jonathan M Skelton, Lee A Burton, Stephen C Parker, Aron Walsh, Chang-Eun Kim, Aloysius Soon, John Buckeridge, Alexey A Sokol, C Richard A Catlow, Atsushi Togo, Isao Tanaka
The layered semiconductor SnSe is one of the highest-performing thermoelectric materials known. We demonstrate, through a first-principles lattice-dynamics study, that the high-temperature Cmcm phase is a dynamic average over lower-symmetry minima separated by very small energetic barriers. Compared to the low-temperature Pnma phase, the Cmcm phase displays a phonon softening and enhanced three-phonon scattering, leading to an anharmonic damping of the low-frequency modes and hence the thermal transport. We develop a renormalization scheme to quantify the effect of the soft modes on the calculated properties, and confirm that the anharmonicity is an inherent feature of the Cmcm phase...
August 12, 2016: Physical Review Letters
Togo Aoyama, Kouju Kamata, Satoshi Kishino
Introduction Studies on the pharmacokinetics of the antibiotic garenoxacin (GRNX) in patients with renal insufficiency are lacking. In this study, we attempted to ascertain the appropriate dose of GRNX in patients undergoing maintenance hemodialysis (MH) based on pharmacokinetic parameters and clinical outcomes. Methods Six male patients with infections who were undergoing MH received 200 mg GRNX once daily. Blood samples were taken before and at 1, 2, 4, 6, 12, and 24 hours after GRNX administration. Plasma GRNX concentrations were measured using high-performance liquid chromatography...
August 22, 2016: Hemodialysis International
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