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Esso-Hanam Atake, Djesika D Amendah
BACKGROUND: In Togo, about half of health care costs are paid at the point of service, which reduces access to health care and exposes households to catastrophic health expenditure (CHE). To address this situation, the Togolese government introduced a National Health Insurance Scheme (NHIS) in 2011. This insurance currently covers only employees and retirees of the State as well as their dependents, although plans for extension exist. This study is the first attempt to examine the extent to which Togo's NHIS protects its members financially against the consequences of ill-health...
March 12, 2018: BMC Health Services Research
Teppei Sasaki, Katsuhiko Moriyama, Hideo Togo
Various 4-aryl-3-bromocoumarins were smoothly obtained in moderate yields in one pot by treating 3-aryl-2-propynoic acids with diaryliodonium triflates and K2 CO3 in the presence of CuCl, followed by the reaction with tetrabutylammonium bromide (TBAB) and Na2 S2 O8 . The obtained 3-bromo-4-phenylcoumarin was transformed into 4-phenylcoumarin derivatives bearing C-H, C-S, C-N, and C-C bonds at 3-position.
2018: Beilstein Journal of Organic Chemistry
Kossi Komlan, Patrick S Vossberg, Richard G Gantin, Tchalim Solim, Francois Korbmacher, Méba Banla, Koffi Padjoudoum, Potchoziou Karabou, Carsten Köhler, Peter T Soboslay
BACKGROUND: Mass drug administration (MDA) of ivermectin has become the main intervention to control onchocerciasis or "river blindness". In Togo, after many years of MDA, Onchocerca volvulus infection has declined dramatically, and elimination appears achievable, but in certain river basins the current situation remains unknown. We have conducted parasitological, serological, ophthalmological, and entomological assessments in northern and central Togo within the river basins of Ôti, Kéran and Mô...
March 1, 2018: PLoS Neglected Tropical Diseases
Taichiro Togo, Toshiya Taniguchi, Yoshitaka Nakata
Aripiprazole (APZ) is used to treat schizophrenia and is administered as a tablet containing the anhydrous form of APZ. In this study, the effect of compaction force on the crystal form transition was investigated. The crystalline state was observed by X-ray diffraction (XRD). APZ Anhydrous Form II was compacted into tablets. The XRD intensity of anhydrous APZ became lower with higher compressive force. The degree of crystallinity decreased with the compaction force. The powder and the compacted tablets of anhydrous APZ were stored for one week under 60°C and 75% relative humidity...
2018: Chemical & Pharmaceutical Bulletin
Rodney N Nagoshi, Georg Goergen, Kodjo Agbeko Tounou, Komi Agboka, Djima Koffi, Robert L Meagher
Fall armyworm (Spodoptera frugiperda J.E. Smith) is a noctuid moth pest endemic throughout the Western Hemisphere that has recently become widespread in sub-Saharan Africa. There is a strong expectation of significant damage to African maize crop yield and a high likelihood of further dispersal, putting the rest of the Eastern Hemisphere at risk. Specimens from multiple locations in six countries spanning the northern portion of the infested region were analyzed for genetic markers. The similarity of haplotypes between the African collections was consistent with a common origin, but significant differences in the relative frequency of the haplotypes indicated limitations in migration...
February 27, 2018: Scientific Reports
B Saka, K Dzidzinyo, S Akakpo, J Téclessou, A Nouhou Diori, N Maneh, G Mahamadou, W Gnassingbé, A Abilogun-Chokki, A Mouhari-Toure, Y Ali Boubacar, K Kombaté, K Balo, K Tchangai-Walla, P Pitché
AIM: The purpose of this study was to identify risk factors associated with the severity of acute ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) in sub-Saharan Africa. PATIENTS AND METHOD: A retrospective study was carried out at the dermatology department in collaboration with the ophthalmology department for SJS/TEN patients between January 2000 and December 2016 in Lomé (Togo). The severity of acute ocular involvement was evaluated using the Power classification, and the drug eruption score was assessed using de Bastuji-Garin classification...
February 24, 2018: Annales de Dermatologie et de Vénéréologie
Bayaki Saka, Boris Tchounga, Didier K Ekouevi, Céphas Sehonou, Essèboè Sewu, Augustin Dokla, Angèle Maboudou, Yao Kassankogno, Vincent Palokinam Pitche
BACKGROUND: Stigma and discrimination experienced by people living with HIV (PLWHA) prevent and delay access to prevention and treatment services. The aim of this study was to describe the patterns of stigma and discrimination experienced by PLWHA in Togo and to identify the associated factors. METHODS: A cross-sectional study was conducted in 2013 among PLWHA in Togo in order to collect data on stigma or discrimination experiences. Univariate and multivariate analyses were performed to identify associated factors...
January 30, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
Vladimir M Moiseyenko, Fedor V Moiseyenko, Grigoriy A Yanus, Ekatherina Sh Kuligina, Anna P Sokolenko, Ilya V Bizin, Alexey A Kudriavtsev, Svetlana N Aleksakhina, Nikita M Volkov, Vyacheslav A Chubenko, Kseniya S Kozyreva, Mikhail M Kramchaninov, Alexandr S Zhuravlev, Kseniya V Shelekhova, Denis V Pashkov, Alexandr O Ivantsov, Aigul R Venina, Tatyana N Sokolova, Elena V Preobrazhenskaya, Natalia V Mitiushkina, Alexandr V Togo, Aglaya G Iyevleva, Evgeny N Imyanitov
BACKGROUND: Colorectal carcinomas (CRCs) are sensitive to treatment by anti-epidermal growth factor receptor (EGFR) antibodies only if they do not carry activating mutations in down-stream EGFR targets (KRAS/NRAS/BRAF). Most clinical trials for chemo-naive CRC patients involved combination of targeted agents and chemotherapy, while single-agent cetuximab or panitumumab studies included either heavily pretreated patients or subjects who were not selected on the basis of molecular tests...
February 22, 2018: Clinical Drug Investigation
Ren Togo, Kenta Ishihara, Katsuhiro Mabe, Harufumi Oizumi, Takahiro Ogawa, Mototsugu Kato, Naoya Sakamoto, Shigemi Nakajima, Masahiro Asaka, Miki Haseyama
AIM: To perform automatic gastric cancer risk classification using photofluorography for realizing effective mass screening as a preliminary study. METHODS: We used data for 2100 subjects including X-ray images, pepsinogen I and II levels, PGI/PGII ratio, Helicobacter pylori ( H. pylori ) antibody, H. pylori eradication history and interview sheets. We performed two-stage classification with our system. In the first stage, H. pylori infection status classification was performed, and H...
February 15, 2018: World Journal of Gastrointestinal Oncology
Shannon L M Whitmer, Thomas Strecker, Daniel Cadar, Hans-Peter Dienes, Kelly Faber, Ketan Patel, Shelley M Brown, William G Davis, John D Klena, Pierre E Rollin, Jonas Schmidt-Chanasit, Elisabeth Fichet-Calvet, Bernd Noack, Petra Emmerich, Toni Rieger, Svenja Wolff, Sarah Katharina Fehling, Markus Eickmann, Jan Philipp Mengel, Tilman Schultze, Torsten Hain, William Ampofo, Kofi Bonney, Juliana Naa Dedei Aryeequaye, Bruce Ribner, Jay B Varkey, Aneesh K Mehta, G Marshall Lyon, Gerrit Kann, Philipp De Leuw, Gundolf Schuettfort, Christoph Stephan, Ulrike Wieland, Jochen W U Fries, Matthias Kochanek, Colleen S Kraft, Timo Wolf, Stuart T Nichol, Stephan Becker, Ute Ströher, Stephan Günther
We describe a strain of Lassa virus representing a putative new lineage that was isolated from a cluster of human infections with an epidemiologic link to Togo. This finding extends the known range of Lassa virus to Togo.
March 2018: Emerging Infectious Diseases
Katsuhiko Moriyama, Tsukasa Hamada, Kazuma Ishida, Hideo Togo
A 1,3-iodo-amination with iodine reagent that involved the Csp2 -Csp3 dual functionalization of 2-methyl indoles was developed to provide 2-aminomethyl-3-iodo-indole derivatives. The iodo-amination proceeded via a 1,4-transfer of an imide group through the formation of an indolyl(phenyl)iodonium imide using PhI(OAc)2 , followed by an iodination using DIH or a double iodination of indole using excess DIH.
February 19, 2018: Chemical Communications: Chem Comm
Yasuhiro Tsuji, Tatsuo Togo, Akio Mishima, Tomomi Koshiyama, Masaaki Ohba
Nonanuclear Ni(ii) complexes, [Ni9(Ln)6(OH)6(H2O)6] (Ni9Ln, n = 1-4; H2Ln = 6-acetoacetyl-2-pyridinecarboxylic acid derivatives), were prepared via self-assembly using the asymmetric multidentate ligands H2Ln. A corner-sharing tetrahedron-type structure, [Ni7(μ3-OH)6]8+, and terminal mononuclear units constitute the nonanuclear structure in a [1-7-1] formation. The electrochemical and magnetic properties of Ni9Ln were modulated by the introduction of various substituents in H2Ln.
February 9, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
G A Yanus, T A Akhapkina, A O Ivantsov, E V Preobrazhenskaya, S N Aleksakhina, I V Bizin, A P Sokolenko, N V Mitiushkina, E S Kuligina, E N Suspitsin, A R Venina, M M Holmatov, O A Zaitseva, O S Yatsuk, D V Pashkov, A M Belyaev, A V Togo, E N Imyanitov, A G Iyevleva
Distribution of cancer-predisposing mutations demonstrates significant interethnic variations. This study aimed to evaluate patterns of APC and MUTYH germ-line mutations in Russian patients with colorectal malignancies. APC gene defects were identified in 26/38 (68%) subjects with colon polyposis; 8/26 (31%) APC mutations were associated with two known mutational hotspots (p.E1309Dfs*4 (n = 5) and p.Q1062fs* (n = 3)), while 6/26 (23%) mutations were novel (p.K73Nfs*6, p.S254Hfs*12, p.S1072Kfs*9, p.E1547Kfs*11, p...
February 6, 2018: Clinical Genetics
Freya M Shearer, Joshua Longbottom, Annie J Browne, David M Pigott, Oliver J Brady, Moritz U G Kraemer, Fatima Marinho, Sergio Yactayo, Valdelaine E M de Araújo, Aglaêr A da Nóbrega, Nancy Fullman, Sarah E Ray, Jonathan F Mosser, Jeffrey D Stanaway, Stephen S Lim, Robert C Reiner, Catherine L Moyes, Simon I Hay, Nick Golding
BACKGROUND: Yellow fever cases are under-reported and the exact distribution of the disease is unknown. An effective vaccine is available but more information is needed about which populations within risk zones should be targeted to implement interventions. Substantial outbreaks of yellow fever in Angola, Democratic Republic of the Congo, and Brazil, coupled with the global expansion of the range of its main urban vector, Aedes aegypti, suggest that yellow fever has the propensity to spread further internationally...
February 1, 2018: Lancet Global Health
Gunnstein Norheim, Judith E Mueller, Berthe-Marie Njanpop-Lafourcade, Isabelle Delrieu, Helen Findlow, Ray Borrow, Ouli Xie, Jerry Nagaputra, Roshan Ramasamy, Christina Dold, Tsidi Agbeko Tamekloe, Christine S Rollier, Hilary Watt, Abiba Banla Kere, Lisbeth M Næss, Andrew J Pollard
BACKGROUND: Capsular group X N. meningitidis (MenX) has emerged as a cause of localized disease outbreaks in sub-Saharan Africa, but the human immune response following exposure to MenX antigens is poorly described. We therefore assessed the natural immunity against MenX in individuals who were living in an area affected by a MenX outbreak during 2007 in Togo, West Africa. During 2009, 300 healthy individuals (100 aged 3-5 years, 100 aged 13-19 years and 100 aged 20-25 years) were included in the study, and serum responses were compared with sera from age-matched controls from the U...
January 31, 2018: Vaccine
Enyonam Tsolenyanu, Koffi E Djadou, Mawouto Fiawoo, Djatougbe A E Akolly, Jason M Mwenda, Eyal Leshem, Jacqueline E Tate, Negar Aliabadi, Winiga Koudema, Koffi M Guedenon, Mawussi Godonou, Anoumou Dagnra, Adama D Gbadoe, Amevegbe Boko, Dadja Landoh, Yawo Atakouma, Umesh D Parashar
BACKGROUND: Monovalent rotavirus vaccine (RV1) was introduced in the immunization schedule of Togo in June 2014. We evaluated the impact of rotavirus vaccines on acute gastroenteritis (AGE) and rotavirus-associated hospitalizations in Togolese children. METHODS: Sentinel surveillance for AGE (defined as ≥3 liquid or semi-liquid stools/24 h lasting <7 days) hospitalizations among children <5 years of age was conducted in two sites in the capital city, Lome...
January 31, 2018: Vaccine
Yoh Shitashima, Togo Shimozawa, Toru Asahi, Atsushi Miyawaki
UnaG is a green-emitting fluorescent protein that utilizes unconjugated bilirubin (BR) as its fluorophore. While BR has captured the attention of physiologists as an important antioxidant that scavenges reactive oxygen species in biological membranes, its excessive accumulation causes several clinical symptoms. Although the optimal regulation of BR concentration would result in clinical therapies for aging as well as reduce risks of clinical symptoms, UnaG hardly releases BR owing to its extremely high affinity for BR (Kd = 98 pM)...
January 27, 2018: Biochemical and Biophysical Research Communications
Komi Mati, Korede K Adegoke, Abimbola Michael-Asalu, Hamisu M Salihu
OBJECTIVE: To examine the effect of the newly introduced national health insurance plan on access to skilled birth attendance (SBA). METHODS: The present secondary analysis used data from the 2014 Togo Demographic and Health Survey. The study sample comprised women aged 15-49 years who had at least one delivery in the 5 years preceding the survey. Multivariate logistic regression analyses were conducted. RESULTS: The adjusted sample included 4826 women...
January 25, 2018: International Journal of Gynaecology and Obstetrics
Herbert Sagbo, Didier Koumavi Ekouevi, Dorland Tafitarilova Ranjandriarison, Serge Niangoran, Tchaa Abalo Bakai, Agbelenko Afanvi, Sewu Dieudonné, Yao Kassankogno, Philippe Vanhems, Nagham Khanafer
OBJECTIVE: Overweight and obesity in childhood are serious public health issues, both in developing and developed countries. The present study aimed to ascertain overweight and obesity prevalence rates among Togolese schoolchildren in Lomé, Togo, and their correlation with physical activity, socio-economic conditions and eating habits. DESIGN: Cross-sectional survey conducted in December 2015. Overweight and obesity were defined using age- and sex-specific BMI cut-off points of the International Obesity Task Force...
January 24, 2018: Public Health Nutrition
Monique A Dorkenoo, Dziedzom K de Souza, Yao Apetogbo, Komla Oboussoumi, Degninou Yehadji, Mawèke Tchalim, Santrao Etassoli, Benjamin Koudou, Guillaume K Ketoh, Yao Sodahlon, Moses J Bockarie, Daniel A Boakye
BACKGROUND: Lymphatic filariasis (LF) is a mosquito-borne filarial disease targeted for elimination by the year 2020. The Republic of Togo undertook mass treatment of entire endemic communities from 2000 to 2009 to eliminate the transmission of the disease and is currently the first sub-Saharan African country to be validated by WHO for the elimination of LF as a public health problem. However, post-validation surveillance activities are required to ensure the gains achieved are sustained...
January 23, 2018: Parasites & Vectors
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