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https://www.readbyqxmd.com/read/28340290/nucleus-accumbens-dopamine-receptors-mediate-hypothalamus-induced-antinociception-in-the-rat-formalin-test
#1
A Siahposht-Khachaki, P Pourreza, S Ezzatpanah, A Haghparast
BACKGROUND: Lateral hypothalamus (LH) involves in modulation of tonic pain. Regarding the direct and indirect neural connections between the LH and nucleus accumbens (NAc), we aimed to examine the pain modulatory role of NAc dopamine receptors in modulation of LH-induced analgesia in the formalin test. METHODS: Vehicle-control groups received saline or DMSO into the NAc and saline into the LH. Carbachol-control groups received carbachol (250 nmol/L) into the LH, 5 min after saline or DMSO injection into the NAc...
March 24, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28340262/effect-of-photoperiod-on-serum-hormone-concentrations-during-the-annual-reproductive-cycle-in-geese
#2
X Z Zhao, G L Gao, H W Wang, Q Li, K S Zhang, H Zhong, Q G Wang
The poor egg-laying rate of geese hinders the development of the goose industry; therefore, the reproductive performance of geese is an important area of investigation. To evaluate the relationship between photoperiod, reproductive hormones, and reproductive activity during the egg-laying cycle in geese under natural conditions, we collected blood samples from Sichuan white geese and Xupu geese to quantify changes in prolactin (PRL), estradiol (E2), vasoactive intestinal polypeptide (VIP), follicle stimulating hormone (FSH), gonadotropin-inhibitory hormone (GnIH), and luteinizing hormone (LH)...
March 22, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28339754/expression-of-deep-brain-photoreceptors-in-the-pekin-drake-a-possible-role-in-the-maintenance-of-testicular-function
#3
R Haas, E Alenciks, S Meddle, G S Fraley
Several putative deep brain photoreceptors (DBPs) have been identified, such as melanopsin, opsin 5, and vertebrate ancient opsin. The aim of this study was to elucidate the role of DBPs in gonadal regulation in the Pekin drake. As previously reported, we observed opsin-like immunoreactivity (-ir) in the lateral septum (LS), melanopsin-ir in the premammillary nucleus (PMM), and opsin 5-ir in the periventricular organ. To determine the sensitivity of the DBPs to specific wavelengths of light, drakes were given an acute exposure to red, blue, or white light...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339646/tgf-%C3%AE-receptor-inhibition-prevents-ventricular-fibrosis-in-a-mouse-model-of-progressive-cardiac-conduction-disease
#4
Mickael Derangeon, Jérôme Montnach, Cynthia Ore Cerpa, Benoit Jagu, Justine Patin, Gilles Toumaniantz, Aurore Girardeau, Christopher Lh Huang, William H Colledge, Andrew A Grace, Isabelle Baró, Flavien Charpentier
Loss-of-function mutations in SCN5A, the gene encoding Nav1.5 channel, have been associated with inherited progressive cardiac conduction disease (PCCD). We have proposed that Scn5a heterozygous knock-out (Scn5a+/-) mice, which are characterized by ventricular fibrotic remodeling with ageing, represent a model for PCCD. Our objectives were to identify the molecular pathway involved in fibrosis development and prevent its activation. Methods and results: Our study shows that myocardial interstitial fibrosis occurred in Scn5a+/- mice only after 45 weeks of age...
February 17, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28339619/relationship-of-neuropeptide-ff-receptors-with-pubertal-maturation-of-gilts%C3%A2
#5
Jennifer F Thorson, Neely L Heidorn, Vitaly Ryu, Krzysztof Czaja, Danny J Nonneman, C Richard Barb, Gary J Hausman, Gary A Rohrer, Ligia D Prezotto, Richard B McCosh, Elane C Wright, Brett R White, Bradley A Freking, William T Oliver, Stanley M Hileman, Clay A Lents
Mechanisms governing the timing of puberty in pigs are poorly understood. A genome-wide association study for age at first estrus in pigs identified candidate genes including neuropeptide FF receptor 2 (NPFFR2), which is a putative receptor for RFamide-related peptides (RFRP). RFRP has been shown to negatively regulate secretion of reproductive hormones from hypothalamic and pituitary tissue of pigs in culture. Here, the porcine NPFFR2 gene was further screened and four potentially functional variants were identified to be associated with age at first estrus in pigs (1,288 gilts)...
January 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28339602/gonadotropin-releasing-hormone-kisspeptin-and-gonadal-steroids-directly-modulate-nucleobindin-2-nesfatin-1-in-murine-hypothalamic-gonadotropin-releasing-hormone-neurons-and-gonadotropes%C3%A2
#6
A Hatef, S Unniappan
Neuroendocrine regulation of metabolism and reproduction are tightly interlinked. Nesfatin-1 is an 82 amino acid metabolic peptide derived from nucleobindin-2 (NUCB2). NUCB2 mRNA and protein significantly increase in the hypothalamus of rats during puberty-to-adult transition. Administration of nesfatin-1 modulates circulating LH and testosterone in male rats. However, whether nesfatin-1 acts directly on neurons and gonadotropes remain unknown. In addition, whether reproductive hormones of the hypothalamo-pituitary gonadal axis modulate NUCB2/nesfatin-1 is unclear...
January 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28339344/correlation-of-leptin-adiponectin-and-resistin-levels-in-different-types-of-lipodystrophy-in-hiv-aids-patients
#7
Danica Srdic, Al Musalhi Khawla, Ivan Soldatovic, Jelena Nikolic, Djordje Jevtovic, Devaki Nair, Gordana Dragovic
BACKGROUND: Leptin, adiponectin, and resistin may play an important role in the development of lipodystrophy (LD) in HIV/AIDS patients. The aim of this study was to correlate levels of leptin, adiponectin, and resistin between HIV/AIDS patients with LD and without lipodystrophy (non-LD), as well as between subgroups of LD [lipoatrophy (LA), lipohypertrophy (LH), and mixed fat redistribution (MFR)] and non-LD patients. METHODS: Cross-sectional study of 66 HIV/AIDS patients...
April 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28335091/assessment-of-genetic-diversity-and-phylogenetic-relationships-of-korean-native-chicken-breeds-using-microsatellite-markers
#8
Joo Hee Seo, Jun-Heon Lee, Hong Sik Kong
In this study, the genetic diversity and phylogenetic relationships of 445 Korean native chickens from five different breeds(Korean Native Chicken (NC), Leghorn (LH), Cornish (CS), Rhode Island Red (RIR), and Hanhyup(HH) commercial line) were studied by performing genotyping using 20 microsatellite (MS) markers. Among the 20 MS markers selected for the genotyping, the number of alleles ranged from 5 (ADL0268) to 20 (MCW0127). The observed heterozygosity (Hobs) ranged from 0.349 (GCT0016) to 0.683 (MCW0145)...
March 21, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28334929/large-scale-preparation-of-a-specific-xanthone-from-swertia-mussotii-and-evaluation-of-its-%C3%AE-glucosidase-inhibitory-activity
#9
Tao Chen, Hongmei Li, Chen Chen, Lixin Wei, Yulin Li
Large-scale preparation and α-glucosidase inhibitory activity of a specific xanthone swertioside from Swertia mussotii were investigated in this study. Firstly, an efficient method was successfully established by liquid-liquid extraction, preparative high-performance liquid chromatography and sephadex LH-20 for large-scale preparation of swertioside. The recovery of swertioside reached 92.0%. Secondly, in vitro α-glucosidase inhibition experiment showed that swertioside had good inhibition close to acarbose...
March 17, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334719/meta-analysis-of-paediatric-patients-with-central-precocious-puberty-treated-with-intramuscular-triptorelin-11-25-mg-3-month-prolonged-release-formulation%C3%A2
#10
Adélaïde Durand, Maithé Tauber, Bharat Patel, Pascale Dutailly
BACKGROUND/AIMS: A meta-analysis was undertaken to assess the effect of triptorelin 11.25 mg 3-month prolonged-release formulation in central precocious puberty (CPP). METHODS: All available clinical studies with triptorelin 11.25 mg were included. The primary outcome was the proportion of children with suppressed luteinising hormone (LH) response (peak LH ≤3 IU/L) to the gonadotrophin-releasing hormone (GnRH) test 3 months after triptorelin 11.25 mg injection...
March 23, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28333280/hcg-activates-the-erk1-2-mitogen-activated-protein-kinase-pathway-in-human-endometrial-stromal-cells-transiently-increasing-the-progesterone-receptor-and-regulating-genes-associated-with-endometrial-receptivity
#11
Alejandro Tapia-Pizarro, Sebastián Archiles, Felipe Argandoña, Cecilia Valencia, Keyla Zavaleta, María Cecilia Johnson, Reinaldo González-Ramos, Luigi Devoto
STUDY QUESTION: How does hCG signal in human endometrial stromal cells (ESCs) and what is its role in regulating ESC function? SUMMARY ANSWER: CG signaling in ESCs activates the extracellular signal-regulated protein kinases 1 and 2 (Erk1/2) pathway through exchange protein activated by cAMP (Epac) and transiently increases progesterone receptor (PR) transcript and protein expression and its transcriptional function. WHAT IS KNOWN ALREADY: hCG is one of the earliest embryo-derived secreted signals in the endometrium, which abundantly expresses LH/hCG receptors...
March 14, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28333263/loss-of-luteotropic-prostaglandin-e-plays-an-important-role-in-the-regulation-of-luteolysis-in-women
#12
Junko Nio-Kobayashi, Masataka Kudo, Noriaki Sakuragi, Toshihiko Iwanaga, W Colin Duncan
STUDY QUESTION: Do intraluteal prostaglandins (PG) contribute to luteal regulation in women? SUMMARY ANSWER: Prostaglandin E (PGE), which is produced in human granulosa-lutein cells stimulated with luteotropic hCG, exerts similar luteotropic effects to hCG, and the expression of PG synthetic and metabolic enzymes in the human CL is driven toward less PGE but more prostaglandin F (PGF) during luteolysis. WHAT IS KNOWN ALREADY: Uterine PGF is a major luteolysin in many non-primate species but not in women...
March 17, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28333238/clustering-of-pcos-like-traits-in-naturally-hyperandrogenic-female-rhesus-monkeys
#13
D H Abbott, B H Rayome, D A Dumesic, K C Lewis, A K Edwards, K Wallen, M E Wilson, S E Appt, J E Levine
STUDY QUESTION: Do naturally occurring, hyperandrogenic (≥1 SD of population mean testosterone, T) female rhesus monkeys exhibit traits typical of women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Hyperandrogenic female monkeys exhibited significantly increased serum levels of androstenedione (A4), 17-hydroxyprogesterone (17-OHP), estradiol (E2), LH, antimullerian hormone (AMH), cortisol, 11-deoxycortisol and corticosterone, as well as increased uterine endometrial thickness and evidence of reduced fertility, all traits associated with PCOS...
March 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28330973/neurokinin-b-regulates-reproduction-via-inhibition-of-kisspeptin-in-a-teleost-the-striped-bass
#14
Nilli Zmora, Ten Tsao Wong, John David Stubblefield, Berta Levavi-Sivan, Yonathan Zohar
Kisspeptin and neurokinin B (NKB) are neuropeptides co-expressed in the mammalian hypothalamus and coordinately control GnRH signaling. We have found that Nkb and kisspeptin neurons are distinct in the teleost, striped bass (stb), and capitalized on this phenomenon to study the mode of action of Nkb and its related neuropeptide-F (Nkf), both of which are encoded by the tac3 gene. In vitro brain slices and in vivo administration studies revealed that Nkb/f consistently down-regulated kiss2, while antagonist (AntD) administration restored this effect...
March 22, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28330768/estrous-detection-by-monitoring-ventral-tail-base-surface-temperature-using-a-wearable-wireless-sensor-in-cattle
#15
Ryotaro Miura, Koji Yoshioka, Toru Miyamoto, Hirofumi Nogami, Hironao Okada, Toshihiro Itoh
In the present study, the ventral tail base surface temperature (ST) was monitored using a wearable wireless sensor for estrus detection in cattle. Relationships among ST, behavioral estrus expression, ovulation, and changes in hormone profiles during the estrous cycle were examined. Holstein Friesian or Japanese Black female cattle were used in summer (August-September), autumn (October-November) and winter (January-February; three animals per season). On Day 11 of the estrous cycle (Day 0=the day of ovulation), the sensor was attached to the surface of the ventral tail base and ST was measured every 2min until Day 11 of the next estrous cycle...
March 11, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28328155/does-dynorphin-play-a-role-in-the-onset-of-puberty-in-female-sheep
#16
J A Lopez, M N Bedenbaugh, R B McCosh, P W Weems, L J Meadows, B Wisman, L M Coolen, R L Goodman, S M Hileman
Puberty onset involves increased gonadotrophin-release (GnRH) release as a result of decreased sensitivity to oestrogen (E2 )-negative feedback. Because GnRH neurones lack E2 receptor α, this pathway must contain interneurones. One likely candidate is KNDy neurones (kisspeptin, neurokinin B, dynorphin). The overarching hypothesis of the present study was that the prepubertal hiatus in luteinising hormone (LH) release involves reduced kisspeptin and/or heightened dynorphin input. We first tested the specific hypothesis that E2 would reduce kisspeptin-immunopositive cell numbers and increase dynorphin-immunopositive cell numbers...
December 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28327126/characterization-and-mechanisms-of-anti-influenza-virus-metabolites-isolated-from-the-vietnamese-medicinal-plant-polygonum-chinense
#17
Thu Thi Tran, Meehyein Kim, Yejin Jang, Hye Won Lee, Hoa Thi Nguyen, Thanh Ngoc Nguyen, Hae Woong Park, Quang Le Dang, Jin-Cheol Kim
BACKGROUND: Polygonum chinense Linn. is a common medicinal plant in Southeast Asia and has been used in traditional medicine in Vietnam. The plant contains phytochemicals with various biological properties; however, its antiviral effect has not yet been demonstrated. This study was aimed to evaluate the anti-influenza virus activity of crude extracts of P. chinense, to characterize antiviral metabolites therefrom and to investigate their mechanisms of antiviral action. METHODS: The methanol (MeOH) extract and organic solvent layers of P...
March 21, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28326886/recurrence-of-hepatocellular-carcinoma-after-laparoscopic-hepatectomy-risk-factors-and-treatment-strategies
#18
Xiaodong Xu, Jiahui Chen, Feiran Wang, Qinggan Ni, Ullah Naimat, Zhong Chen
PURPOSE: To investigate the risk factors for recurrence and treatment strategies after patients with hepatocellular carcinoma (HCC) undergo total laparoscopic hepatectomy (LH). METHODS: The study included 109 patients who underwent LH (laparoscopy resection [LR] group, n = 50) or open hepatectomy [OH] (open resection [OR] group, n = 59) for HCC in our hospital between March 2011 and June 2016. Perioperative outcomes, disease recurrence, survival, and risk factors for recurrence were analyzed...
March 22, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28326632/reproductive-performance-of-postpartum-ewes-treated-with-insulin-or-progesterone-hormones-in-association-with-ram-effect
#19
J C Ferreira-Silva, Srl Basto, F Tenório Filho, M T Moura, M L Silva Filho, Mal Oliveira
The reproductive performance of postpartum Santa Inês (SI) and Morada Nova (MN) ewes treated with insulin or progesterone hormones in association with ram effect was evaluated. Ewes from SI (n = 69) and MN (n = 69) breeds were randomly allocated to three groups of each breed (T1-ram effect only; T2-ram effect + insulin; T3-ram effect + progesterone). Progesterone concentrations (ηg/ml; mean ± SD) before and after introduction of rams (n = 6) were 0.51 ± 0.22 and 3.78 ± 0.68 (T1), 0.65 ± 0...
March 22, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28326319/inhibitory-activities-of-stauntonia-hexaphylla-leaf-constituents-on-rat-lens-aldose-reductase-and-formation-of-advanced-glycation-end-products-and-antioxidant
#20
Seung Hwan Hwang, Shin Hwa Kwon, Set Byeol Kim, Soon Sung Lim
Stauntonia hexaphylla (Thunb.) Decne. (Lardizabalaceae) leaves (SHL) have been used traditionally as analgesics, sedatives, diuretics, and so on, in China. To date, no data have been reported on the inhibitory effect of SHL and its constituents on rat lens aldose reductase (RLAR) and advanced glycation end products (AGEs). Therefore, the inhibitory effect of compounds isolated from SHL extract on RLAR and AGEs was investigated to evaluate potential treatments of diabetic complications. The ethyl acetate (EtOAC) fraction of SHL extract showed strong inhibitory activity on RLAR and AGEs; therefore, EtOAc fraction (3...
2017: BioMed Research International
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