keyword
https://read.qxmd.com/read/38544669/modulating-the-rfamide-related-peptide-3-g-protein-coupled-receptor-147-signaling-pathway-with-nourishing-yin-removing-fire-herbal-mixture-to-alleviate-precocious-puberty-in-female-rats-an-experimental-study
#1
JOURNAL ARTICLE
Xiaoli Dai, Yuanyuan He, Suhuan Li, Yanyan Sun, Wen Sun, Zhanzhuang Tian, Ph D, Jian Yu, Ph D, Nurgul Ablakimova, Yonghong Wang
BACKGROUND: Precocious puberty (PP) involves early activation of the hypothalamic gonadotropin-releasing hormone (GnRH) generator. The RFamide-related peptide/G protein-coupled receptor 147 ( RFRP3/GPR147 ) signaling pathway is vital in inhibiting GnRH and delaying puberty onset. The nourishing Yin-removing fire (NYRF) herbal mixture has shown promising results in treating PP. OBJECTIVE: This study aimed to assess the impact of the NYRF herbal mixture on the RFRP3/GPR147 signaling pathway in the hypothalamus and its potential in alleviating PP in female rats...
January 2024: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/38544436/life-history-strategies-of-male-criminal-offenders-verifying-traditional-life-history-patterns
#2
JOURNAL ARTICLE
Monika Kwiek, Przemyslaw Piotrowski
Life history (LH) strategies are results of trade-offs that species must make due to inhabiting certain ecological niches. Although it is assumed that, through the process of developmental plasticity, similar trade-offs are made by individuals in response to a certain level of harshness and unpredictability of their local environments, the study results on this matter are not consistent. In LH-oriented psychological research, such inconsistencies are often explained as a consequence of significant individual differences in phenotypical quality and owned resources, which make studying trade-offs difficult due to different costs and benefits of the same behaviors taken by different individuals...
2024: Evolutionary Psychology: An International Journal of Evolutionary Approaches to Psychology and Behavior
https://read.qxmd.com/read/38542167/effect-of-gnrh-active-immunisation-on-reproductive-performance-of-male-sprague-dawley-rats
#3
JOURNAL ARTICLE
Cheng-Qi Zhang, Shuang-Shuang Li, Bo Hu, Li-Wen Xu, Jia-Jia Liu, Ya-Jie Sun, Xue Bai
To investigate the effect of active immunisation with gonadotropin-releasing hormone (GnRH) on the reproductive function in male Sprague Dawley (SD) rats, 24 42-day-old rats were randomly assigned to treatment with GnRH6-MAP, GnRH-OVA, a surgical castration group, and a blank control group. Each rat in the treatment groups was intramuscularly injected at 6, 8, and 10 weeks of age. The serum concentrations of testosterone (T), follicle-stimulating hormone (FSH), luteinising hormone (LH), and anti-GnRH antibodies were determined using enzyme-linked immunosorbent assays...
March 11, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541222/does-basal-morning-luteinizing-hormone-blh-predict-central-precocious-puberty-cpp-in-girls
#4
JOURNAL ARTICLE
Federico Baronio, Valentina Assirelli, Giuseppina Deiana, Randa AlQaisi, Rita Ortolano, Valeria Di Natale, Egidio Candela, Alessandra Cassio
Background and Objectives : bLH is considered an excellent biochemical predictor of CPP. However, its utilization in clinical practice shows some uncertainties. This study aims to evaluate the diagnostic power of bLH and propose a diagnostic algorithm for CPP. Materials and Methods : We conducted a monocentric cohort retrospective study evaluating all females referred for suspicion of CPP between 1 January 2017 and 31 December 2020 who underwent a GnRH test. Auxological, hormonal, and instrumental data were collected, including pelvic ultrasonography and bone age (BA) assessment...
March 18, 2024: Medicina
https://read.qxmd.com/read/38541016/the-correlation-between-sex-hormone-binding-globulin-and-clinical-characteristics-according-to-anti-m%C3%A3-llerian-hormone-in-women-with-regular-menstrual-cycles-a-prospective-study
#5
JOURNAL ARTICLE
Jihyun Keum, Yong Jin Kim, Sae Kyung Choi, Won Moo Lee, Jaeman Bae
BACKGROUND: Polycystic ovarian syndrome (PCOS) can be diagnosed when the anti-Müllerian hormone (AMH) levels are high, but in clinic, women who do not meet the diagnosis of PCOS but have elevated AMH levels are often seen. This study aimed to compare the differences in menstrual cycle patterns and hormone levels in women with regular menstrual cycles, but not PCOS, by dividing them into high and low AMH groups. MATERIAL AND METHODS: This multicenter prospective study included 68 healthy women...
February 29, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38540938/modulatory-effects-of-lactarius-hatsudake-on-obesity-and-gut-microbiota-in-high-fat-diet-fed-c57bl-6-mice
#6
JOURNAL ARTICLE
Hanyu Zhu, Tao Hou
Lactarius hatsudake (LH), a great wild endemic fungus, contains rich nutritional components with medicinal properties. The effects of LH on body weight, liver weight, liver injury, blood lipids, and gut microbiota in C57BL/6 mice fed a high-fat diet (HFD) for 8 weeks was examined in this research. Though there was no clear impact on weight loss, the findings indicate that LH treatment effectively decreased liver damage caused by HFD, as well as lowered serum total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol levels...
March 20, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38540731/what-we-are-learning-from-the-diverse-structures-of-the-homodimeric-type-i-reaction-center-photosystems-of-anoxygenic-phototropic-bacteria
#7
REVIEW
Robert A Niederman
A Type I reaction center (RC) (Fe-S type, ferredoxin reducing) is found in several phyla containing anoxygenic phototrophic bacteria. These include the heliobacteria (HB), the green sulfur bacteria (GSB), and the chloracidobacteria (CB), for which high-resolution homodimeric RC-photosystem (PS) structures have recently appeared. The 2.2-Å X-ray structure of the RC-PS of Heliomicrobium modesticaldum revealed that the core PshA apoprotein (PshA-1 and PshA-2 homodimeric pair) exhibits a structurally conserved PSI arrangement comprising five C-terminal transmembrane α-helices (TMHs) forming the RC domain and six N-terminal TMHs coordinating the light-harvesting (LH) pigments...
March 6, 2024: Biomolecules
https://read.qxmd.com/read/38540173/mechanisms-and-target-parameters-in-relation-to-polycystic-ovary-syndrome-and-physical-exercise-focus-on-the-master-triad-of-hormonal-changes-oxidative-stress-and-inflammation
#8
REVIEW
Csanád Endre Lőrincz, Denise Börzsei, Alexandra Hoffmann, Csaba Varga, Renáta Szabó
Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females of reproductive age with heterogeneous prevalence. It is well known that female reproductive competence depends on the dynamic regulation of the hypothalamic-pituitary-gonadal (HPG) axis; therefore, disruption of this highly regulated system leads to fertility problems. Among disruptors, both oxidative stress and inflammation contribute to an increased LH-FSH ratio and a consequent hyperandrogenism. Shifts in this bidirectional interplay between the neuroendocrine system and oxidative/inflammatory homeostasis result in the accumulation of reactive oxygen/nitrogen species and inflammatory markers as well as alterations in antioxidant defense mechanisms...
March 1, 2024: Biomedicines
https://read.qxmd.com/read/38539883/two-generation-toxicity-study-of-the-antioxidant-compound-propyl-propane-thiosulfonate-ptso
#9
JOURNAL ARTICLE
Antonio Cascajosa-Lira, Remedios Guzmán-Guillén, Silvia Pichardo, Alberto Baños, Jose M de la Torre, Nahum Ayala-Soldado, M Rosario Moyano-Salvago, Isabel Ortiz-Jaraba, Ana M Cameán, Angeles Jos
Propyl-propane thiosulfonate (PTSO), an antioxidant organosulfur compound present in the genus Allium , has become a potential natural additive for food and feed, as well as a possible biopesticide for pest control in plants. A toxicological assessment is necessary to verify its safety for livestock, consumers, and the environment. As part of the risk assessment of PTSO, this study was designed to explore its potential reproductive toxicity in mice following the OECD 416 guideline. The investigation spans two generations to comprehensively evaluate potential reproductive, teratogenic, and hereditary effects...
March 15, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539664/the-association-among-hypothalamic-subnits-gonadotropic-and-sex-hormone-plasmas-levels-in-alzheimer-s-disease
#10
JOURNAL ARTICLE
Edward Ofori, Anamaria Solis, Nahid Punjani, On Behalf Of The Alzheimer's Disease Neuroimaging Initiative
This study investigates the sex-specific role of the Hypothalamic-Pituitary-Gonadal axis in Alzheimer's disease progression, utilizing ADNI1 data for 493 individuals, analyzing plasma levels of gonadotropic and sex hormones, and examining neurodegeneration-related brain structures. We assessed plasma levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P4), and testosterone (T), along with volumetric measures of the hippocampus, entorhinal cortex, and hypothalamic subunits, to explore their correlation with Alzheimer's disease markers across different cognitive statuses and sexes...
March 14, 2024: Brain Sciences
https://read.qxmd.com/read/38538470/diagnosis-and-management-of-congenital-hypopituitarism-in-children
#11
Sarah Castets, Cécile Thomas-Teinturier, Carine Villanueva, Jessica Amsellem, Pascal Barat, Gilles Brun, Emmanuel Bui Quoc, Jean-Claude Carel, Gian Paolo De Filippo, Clara Kipnis, Laetitia Martinerie, Julia Vergier, Alexandru Saveanu, Natacha Teissier, Régis Coutant, Juliane Léger, Rachel Reynaud
Hypopituitarism (or pituitary deficiency) is a rare disease with an estimated prevalence of between 1/16,000 and 1/26,000 individuals, defined by insufficient production of one or several anterior pituitary hormones (growth hormone [GH], thyroid-stimulating hormone [TSH], adrenocorticotropic hormone [ACTH], luteinizing hormone [LH], follicle-stimulating hormone [FSH], prolactin), in association or not with diabetes insipidus (antidiuretic hormone [ADH] deficiency). While in adults hypopituitarism is mostly an acquired disease (tumors, irradiation), in children it is most often a congenital condition, due to abnormal pituitary development...
March 26, 2024: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://read.qxmd.com/read/38537155/giredestrant-for-estrogen-receptor-positive-her2-negative-previously-treated-advanced-breast-cancer-results-from-the-randomized-phase-ii-acelera-breast-cancer-study
#12
JOURNAL ARTICLE
Miguel Martín, Elgene Lim, Mariana Chavez-MacGregor, Aditya Bardia, Jiong Wu, Qingyuan Zhang, Zbigniew Nowecki, Felipe Melo Cruz, Rustem Safin, Sung-Bae Kim, Christian Schem, Alberto J Montero, Sarah Khan, Reeti Bandyopadhyay, Heather M Moore, Mahesh Shivhare, Monika Patre, Jorge Martinalbo, Laura Roncoroni, Pablo Diego Pérez-Moreno, Joohyuk Sohn
PURPOSE: To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor-positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455). METHODS: Post-/pre-/perimenopausal women, or men, age 18 years or older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines of systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly assigned 1:1 to giredestrant (30 mg oral once daily) or fulvestrant/aromatase inhibitor per local guidelines (+luteinizing hormone-releasing hormone agonist in pre-/perimenopausal women, and men) until disease progression/unacceptable toxicity...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38535787/alleviative-effect-of-rutin-on-zearalenone-induced-reproductive-toxicity-in-male-mice-by-preventing-spermatogenic-cell-apoptosis-and-modulating-gene-expression-in-the-hypothalamic-pituitary-gonadal-axis
#13
JOURNAL ARTICLE
Hira Sayed, Qiongqiong Zhang, Yu Tang, Yanan Wang, Yongpeng Guo, Jianyun Zhang, Cheng Ji, Qiugang Ma, Lihong Zhao
Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin found in many agricultural products and can cause reproductive disorders, mainly affecting spermatogenesis in male animals. Rutin (RUT) is a natural flavonoid compound recognized for its significant antioxidant, anti-inflammatory and estrogenic properties. The present study aimed to determine the protective role of RUT against ZEN-induced reproductive toxicity in male mice. Twenty-four adult Kunming male mice were divided into four groups: control, RUT (500 mg/kg RUT), ZEN (10 mg/kg ZEN), ZEN + RUT (500 mg/kg RUT + 10 mg/kg ZEN), with six replicates per treatment...
February 29, 2024: Toxins
https://read.qxmd.com/read/38534181/outdoor-artificial-light-at-night-and-reproductive-endocrine-and-glucose-homeostasis-and-polycystic-ovary-syndrome-in-women-of-reproductive-age
#14
JOURNAL ARTICLE
Lanlan Fang, Cong Ma, Guosheng Wang, Yongzhen Peng, Hui Zhao, Yuting Chen, Yubo Ma, Guoqi Cai, Yunxia Cao, Faming Pan
BACKGROUND: Artificial light at night, a well-recognized circadian clock disrupter, causes disturbances in endocrine homeostasis. However, the association of artificial light at night with polycystic ovary syndrome (PCOS) is still unknown. This study examines the effects of outdoor artificial light at night on sex hormones, glucose homeostasis markers, and PCOS prevalence in Anhui Province, China. METHODS: We recruited 20633 women of reproductive age from Anhui Medical University Reproductive Medicine Center...
March 22, 2024: Epidemiology
https://read.qxmd.com/read/38533595/effect-of-leptin-on-nitrergic-neurons-in-the-lateral-hypothalamic-area-and-the-supraoptic-nucleus-of-rats
#15
JOURNAL ARTICLE
Milen Hristov, Boycho Landzhov, Krassimira Yakimova
The adipocyte-derived hormone, leptin, plays a key role in the maintenance of energy homeostasis. Leptin binds to the long form of its receptor, which is predominantly expressed in various hypothalamic regions, including the lateral hypothalamic area (LH) and supraoptic nucleus (SO). Several studies have suggested that leptin directly activates neuronal nitric oxide synthase, leading to increased nitric oxide production. We used histochemistry for nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) as a marker for nitric oxide synthase activity and assessed the effect of leptin on nitrergic neurons in the LH and SO of rats...
March 27, 2024: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://read.qxmd.com/read/38533288/protective-effect-of-baclofen-on-ovarian-cystogenesis-and-morphine-induced-lipid-profile-change-in-female-rats
#16
JOURNAL ARTICLE
Zahra Jamshidi, Manizheh Karami, Mohsen Khalili, Mehrdad Roghani
INTRODUCTION: Morphine induces ovarian cysts that cause obesity and disrupt sex hormone secretion. Baclofen, a gamma-aminobutyric acid receptor agonist, can help regulate sex hormones and reduce harmful blood lipids by protecting against morphine-induced gamma-aminobutyric acid inhibition. We investigated the prophylactic effect of baclofen in rats receiving morphine by comparing with the untreated groups. MATERIALS AND METHODS: Forty eight female Wistar rats were randomly divided into several groups, including control (saline 1 mL/kg, i...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532178/performance-of-intraoperative-neurocognitive-tests-during-awake-surgery-for-patients-with-diffuse-low-grade-glioma
#17
JOURNAL ARTICLE
Lucas Alverne F Albuquerque, Leonardo José Monteiro de Macêdo Filho, Felipe Silva Borges, Gabryella S Diógenes, Fátima C Pessoa, Cicera Jairlly Veras Rocha, João Paulo Almeida, Enrico Ghizoni, Andrei F Joaquim
Despite great advancements and the diffusion of awake surgery for brain tumors, the literature shows that the tests applied during the procedure are heterogeneous and non-standardized. This prospective, observational, descriptive study collected data on intraoperative brain mapping and the performance of multiple neurocognitive tests in 51 awake surgeries for diffuse low-grade glioma. Frequency of use and rate of intraoperative findings of different neurocognitive tests were analyzed. Patients mean age at the time of surgery was 35...
March 27, 2024: Neurosurgical Review
https://read.qxmd.com/read/38531779/clinical-and-gonadal-transcriptome-analysis-of-38-xx-disorder-of-sex-development-pigs
#18
JOURNAL ARTICLE
Jinhua Wu, Shuwen Tan, Yi Zhou, Haiquan Zhao, Hui Yu, Bingzhou Zhong, Congying Yu, Haoming Wang, Yin Yang, Hua Li, Yugu Li
Pigs serve as a robust animal model for the study of human diseases, notably in the context of disorders of sex development (DSD). This study aims to investigate the phenotypic characteristics and molecular mechanisms underlying the reproductive and developmental abnormalities of 38,XX ovotestis-DSD (OT-DSD) and 38,XX testis-DSD (T-DSD) in pigs. Clinical and transcriptome sequencing analyses were performed on DSD and normal female pigs. Cytogenetic and SRY analyses confirmed that OT/T-DSD pigs exhibited a 38,XX karyotype and lacked the SRY gene...
March 26, 2024: Biology of Reproduction
https://read.qxmd.com/read/38530255/energy-transfer-and-exciton-relaxation-in-b880-b800-rc-complex-through-two-dimensional-electronic-spectroscopy
#19
JOURNAL ARTICLE
Xiang-Ping Wang, Buyang Yu, Chen-Hui Qi, Guang-Lei Wang, Meijuan Zou, Chunfeng Zhang, Long-Jiang Yu, Fei Ma
The light-harvesting (LH) and reaction center (RC) core complex of purple bacterium Roseiflexus castenholzii , B880-B800-RC, are different from those of the typical photosynthetic unit, (B850-B800) x -B880-RC. To investigate the excitation flowing dynamics in this unique complex, two-dimensional electronic spectroscopy is employed. The obtained time constants for the exciton relaxation in B880, exciton relaxation in B800, B800 → B880 energy transfer (EET), and B880 → closed RC EET are 43 fs, 177 fs, 1...
March 26, 2024: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/38530023/a-case-of-mild-partial-androgen-insensitivity-syndrome-in-a-juvenile-boy
#20
JOURNAL ARTICLE
Fen Wang, Shiying Shao, Wentao He, Shuhong Hu
Androgen insensitivity syndrome (AIS) is a rare disorder with X-linked recessive inheritance in 46 XY patients. The clinical manifestations vary between patients, especially regarding external genitalia development. Herein, the case of AIS in a 13-year-old male, who was born with hypospadias and presented to the hospital with gynaecomastia that had developed from 8 years of age, is reported. No micropenis, cryptorchidism or bifid scrotum were found. Testis volume was 12 ml on both sides. His testosterone and luteinizing hormone levels were normal compared with sex- and age-adjusted reference range...
March 2024: Journal of International Medical Research
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