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https://www.readbyqxmd.com/read/28102379/the-pyrrole-ring-%C3%AE-2-hapticity-bridged-binuclear-tricarbonyl-mo-0-and-w-0-complexes-catalysis-of-regioselective-hydroamination-reactions-and-dft-calculations
#1
Vikesh Kumar Jha, Ganesan Mani, Yogeswara Rao Davuluri, Anakuthil Anoop
Following the report of the ferrocene structure, metal complexes containing the heteroatom-substituted cyclopentadienyl (Cp) analogue, that is the η(5) pyrrolyl ligand, have been reported. While the Cp ligand continues to be a favorite ligand in organometallics, the transition metal chemistry of the pyrrolyl ligand is still in the developing stage. In view of this, we carried out the reaction between the multidentate ligand 2,3,4,5-tetrakis(3,5-dimethylpyrazolylmethyl)pyrrole (LH) and Mo(CO)6 or [W(CO)3(CH3CN)3] and isolated two new binuclear tricarbonyl Mo(0) and W(0) complexes, [Mo2(CO)6(μ-η(2):η(2)-LH-κ(4)N)] (1) and [W2(CO)6(μ-η(2):η(2)-LH-κ(4)N)] (2)...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28101307/review-and-recommendations-on-management-of-adult-female-thalassemia-patients-with-hypogonadism-based-on-literature-review-and-experience-of-icet-a-network-specialists
#2
REVIEW
Vincenzo De Sanctis, Ashraf T Soliman, Heba Elsedfy, Alice Albu, Soad Al Jaouni, Salvatore Anastasi, Maria Grazia Bisconte, Duran Canatan, Soteroula Christou, Shahina Daar, Salvatore Di Maio, Mohamed El Kholy, Doaa Khater, Mohamed Elshinawy, Yurdanur Kilinc, Roberto Mattei, Hala H Mosli, Alessandra Quota, Maria Grazia Roberti, Praveen Sobti, Saif Al Yaarubi, Saveria Canpisi, Christos Kattamis
BACKGROUND: Multi-transfused thalassemia major (TM) patients frequently develop severe endocrine complications, mainly due to iron overload, anemia, and chronic liver disease, which require prompt diagnosis, treatment and follow-up by specialists. The most common endocrine complication documented is hypogonadotropic hypogonadism which increases with age and associated comorbidities. It is thus important for physicians to have a clear understanding of the pathophysiology and management of this disorder...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28100869/gonadotoropin-actions-on-spermatogenesis-and-hormonal-therapies-for-spermatogenic-disorders-review
#3
Koji Shiraishi, Hideyasu Matsuyama
Microdissection testicular sperm extraction and intracytoplasmic sperm injection have made it possible for men with non-obstructive azoospermia (NOA) to conceive a child. A majority of men cannot produce sperm because spermatogenesis per se is believed to be "irreversibly" disturbed. For these men, it and has been thought that any hormonal therapy will be ineffective. Further understandings of endocrinological regulation of spermatogenesis are needed and LH or FSH receptor knock out (KO) mice have revealed the roles of gonadotropin separately...
January 19, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28100484/atf6-knock-down-decreases-apoptosis-arrests-the-s-phase-of-the-cell-cycle-and-increases-steroid-hormone-production-in-mouse-granulosa-cells
#4
Yongjie Xiong, Huatao Chen, Pengfei Lin, Aihua Wang, Lei Wang, Yaping Jin
Activating transcription factor 6 (ATF6) is an important factor in the endoplasmic reticulum (ER) stress signaling pathway. The aim of this study was to assess the role of ATF6 in mouse granulosa cells with respect to apoptosis, the cell cycle, and steroid hormone production, as well as several key genes related to follicular development, via RNA interference, immunohistochemical staining, real-time quantitative polymerase chain reaction, western blotting, flow cytometry, TUNEL assay, and ELISA. Immunohistochemical staining revealed that ATF6 was extensively distributed in the granulosa cells of various ovarian follicles and oocytes in adult female mice...
January 18, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28100207/rate-and-associated-factors-of-non-retention-of-mother-baby-pairs-in-hiv-care-in-the-elimination-of-mother-to-child-transmission-programme-gulu-uganda-a-cohort-study
#5
Gerald Obai, Ruth Mubeezi, Fredrick Makumbi
BACKGROUND: Poor retention in HIV care of mother-baby pairs remains a public health challenge in the elimination of mother-to-child transmission (eMTCT) of HIV. We determined the rate of non-retention and time to non-retention of mother-baby pairs and associated factors in Gulu district, Northern Uganda. METHODS: Mother-baby pairs enrolled into the eMTCT programme at Gulu Regional Referral Hospital (GRRH) and Lacor Hospital (LH) were retrospectively followed for 18 months...
January 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28099447/genome-wide-immune-modulation-of-tlr3-mediated-inflammation-in-intestinal-epithelial-cells-differs-between-single-and-multi-strain-probiotic-combination
#6
Chad W MacPherson, Padmaja Shastri, Olivier Mathieu, Thomas A Tompkins, Pierre Burguière
Genome-wide transcriptional analysis in intestinal epithelial cells (IEC) can aid in elucidating the impact of single versus multi-strain probiotic combinations on immunological and cellular mechanisms of action. In this study we used human expression microarray chips in an in vitro intestinal epithelial cell model to investigate the impact of three probiotic bacteria, Lactobacillus helveticus R0052 (Lh-R0052), Bifidobacterium longum subsp. infantis R0033 (Bl-R0033) and Bifidobacterium bifidum R0071 (Bb-R0071) individually and in combination, and of a surface-layer protein (SLP) purified from Lh-R0052, on HT-29 cells' transcriptional profile to poly(I:C)-induced inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/28099131/turner-syndrome-and-pituitary-adenomas-a-case-report-and-review-of-literature
#7
Tiffany Yeh, Angela Ganan Soto, Jose Bernardo Quintos, Lisa Swartz Topor
BACKGROUND: Turner syndrome (TS) is the most common sex chromosome abnormality in females, typically associated with primary amenorrhea and premature ovarian failure due to gonadal dysgenesis. The association of TS with hypopituitarism is an uncommon finding. The objective of the study was to describe an adolescent with TS with hypergonadotropic hypogonadism and subsequent hypogonadotropic hypogonadism. CASE PRESENTATION: A 16-year-old female with primary amenorrhea was diagnosed with TS based on karyotype 45,XO...
January 18, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28099050/lipohypertrophy-in-china-prevalence-risk-factors-insulin-consumption-and-clinical-impact
#8
Linong Ji, Zilin Sun, Qifu Li, Guijun Qin, Zheng Wei, Junhao Liu, Arthi B Chandran, Laurence J Hirsch
BACKGROUND: Lipohypertrophy (LH) is a complication of insulin therapy. We assessed LH prevalence, risk factors, insulin usage, and clinical and health economic effects in China. METHODS: In four cities, 401 adult patients injecting insulin ≥1 year were surveyed for diabetes/insulin injection history and practices, pen needle reimbursement (PNR), and health resource utilization, followed by structured examination and HbA1c testing. Differences between those with and without LH were evaluated by Student's t-test or the Wilcoxon rank sum test...
January 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28093458/single-cell-gene-expression-analysis-reveals-diversity-among-human-spermatogonia
#9
N Neuhaus, J Yoon, N Terwort, S Kliesch, J Seggewiss, A Huge, R Voss, S Schlatt, R V Grindberg, H R Schöler
STUDY QUESTION: Is the molecular profile of human spermatogonia homogeneous or heterogeneous when analysed at the single-cell level? SUMMARY ANSWER: Heterogeneous expression profiles may be a key characteristic of human spermatogonia, supporting the existence of a heterogeneous stem cell population. WHAT IS KNOWN ALREADY: Despite the fact that many studies have sought to identify specific markers for human spermatogonia, the molecular fingerprint of these cells remains hitherto unknown...
January 15, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28093190/ghrelin-fibers-from-lateral-hypothalamus-project-to-nucleus-tractus-solitaries-and-are-involved-in-gastric-motility-regulation-in-cisplatin-treated-rats
#10
Yanling Gong, Yang Liu, Fei Liu, Shasha Wang, Hong Jin, Feifei Guo, Luo Xu
Ghrelin can alleviate cancer chemotherapy-induced dyspepsia in rodents, though the neural mechanisms involved are not known. Therefore, ghrelin projections from the lateral hypothalamus (LH) and its involvement in the regulation of gastric motility in cisplatin-treated rats were investigated with a multi-disciplined approach. Retrograde tracing combined with fluoro-immunohistochemical staining were used to investigate ghrelin fiber projections arising from LH and projecting to nucleus tractus solitaries (NTS)...
January 13, 2017: Brain Research
https://www.readbyqxmd.com/read/28092404/metformin-versus-myoinositol-which-is-better-in-obese-pcos-patients-a-randomized-controlled-crossover-study
#11
Valeria Tagliaferri, Daniela Romualdi, Valentina Immediata, Simona De Cicco, Christian Di Florio, Antonio Lanzone, Maurizio Guido
CONTEXT: due to the central role of metabolic abnormalities in the pathophysiology of PCOS, insulin sensitising agents have been proposed as a feasible treatment option. OBJECTIVE: to investigate which is the more effective between metformin and myoinositol on hormonal, clinical and metabolic parameters in obese patients with polycystic ovary syndrome (PCOS). STUDY DESIGN: crossover randomized-controlled study. PATIENTS: Thirty-four PCOS obese women (age: 25...
January 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28091600/urinary-profiles-of-luteinizing-hormone-estrogen-and-progestagen-during-the-estrous-and-gestational-periods-in-giant-pandas-ailuropda-melanoleuca
#12
Kailai Cai, Shangmian Yie, Zhihe Zhang, Juan Wang, Zhigang Cai, Li Luo, Yuliang Liu, Hairui Wang, He Huang, Chengdong Wang, Xiangming Huang, Jingchao Lan, Rong Hou
Luteinizing hormone (LH) is one of the main pituitary hormones that regulate ovulation, however its role has not been studied in giant panda. In this study, we developed an ELISA method for the detection of panda urinary LH. We analyzed urinary hormones of 24 female pandas during 36 breeding periods, we found females could easily be impregnated if the first mating occurred within 10 hours after LH peak. We also found the patterns of the ratios of urinary LH and progestagen in pandas that bred and successfully gave birth were significantly different from those that bred but failed to give birth...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090002/easy-detection-of-hormone-secretion-from-l%C3%AE-t2-cells-by-using-gaussia-luciferase
#13
Kazuhiro Satou, Yuta Mochimaru, Takashi Nakakura, Tomoyuki Kusada, Jun Negishi, Shiori Musha, Nanaka Yoshimura, Yukio Kato, Hideaki Tomura
Reproduction is regulated by gonadotropins secreted from gonadotrophs. The production and secretion of gonadotropins are mainly regulated by gonadotropin-releasing hormone (GnRH). Agonists or antagonists that influence GnRH action on gonadotrophs are important to regulate reproduction; however, these factors have not been fully characterized due to the lack of simple and easy-to-use techniques to detect gonadotropin secretion from gonadotropin-producing cells. In the present study, we found that Gaussia luciferase (Gluc), which was expressed in LβT2 cells, can be secreted like a luteinizing-hormone (LH) upon stimulation with GnRH...
January 15, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28089693/effects-of-six-priority-controlled-phthalate-esters-with-long-term-low-dose-integrated-exposure-on-male-reproductive-toxicity-in-rats
#14
Hai-Tao Gao, Run Xu, Wei-Xin Cao, Liang-Liang Qian, Min Wang, Lingeng Lu, Qian Xu, Shu-Qin Yu
Human beings are inevitably exposed to ubiquitous phthalate esters (PEs) surroundings. The purposes of this study were to investigate the effects of long-term low-dose exposure to the mixture of six priority controlled phthalate esters (MIXPs): dimethyl phthalate (DMP), diethyl phthalate (DEP), di(n-butyl) phthalate (DBP), butyl benzyl phthalate (BBP), di(2-ethyhexyl) phthalate (DEHP) and di-n-octyl phthalate (DNOP), on male rat reproductive system and further to explore the underlying mechanisms of the reproductive toxicity...
January 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28089561/characterizing-deep-white-matter-hyperintensities-in-patients-with-symptomatic-isolated-cortical-superficial-siderosis
#15
Dimitri Renard, Lavinia Tatu, Christophe Demattei, Christophe Hirtz, Sylvain Lehmann, Eric Thouvenot
BACKGROUND: In patient with cerebral amyloid angiopathy (CAA) presenting with lobar hemorrhage (LH), magnetic resonance imaging (MRI) white matter hyperintensities (WMH) tend to be predominant in posterior regions with the "multiple subcortical spots" WMH pattern as the most frequent topographical WMH pattern. Our aim was to analyze WMH severity and topographical distribution in patients with cortical superficial siderosis (CSS). METHODS: We retrospectively analyzed MRIs from consecutive symptomatic isolated (i...
January 12, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28088261/parquetina-nigrescens-leaves-chemical-profile-and-influence-on-the-physical-and-biochemical-indices-of-sexual-activity-of-male-wistar-rats
#16
Omowumi Titilola Kayode, Musa Toyin Yakubu
OBJECTIVE: The leaves of Parquetina nigrescens have been claimed in folk medicine to be useful for managing sexual dysfunction, but there is inadequate scientific evidence for this claim. This investigation was conducted to assess the effects of aqueous leaf extract of Parquetina nigrescens (AEPN) in rats induced with sexual dysfunction. METHODS: Male rats were allocated into various groups after being induced into sexual dysfunction with paroxetine hydrochloride...
January 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28087978/identification-of-gonadotropin-releasing-hormone-metabolites-in-greyhound-urine
#17
David Palmer, Katie Rademaker, Ingrid Martin, Joan Hessell, Rob Howitt
Gonadotropin-releasing hormone (GnRH) is a 10-residue peptide hormone that induces secretion of luteinizing hormone (LH) and follicle-stimulating hormone into the blood from the pituitary gland. In males, LH acts on the testes to produce testosterone. The performance enhancing potential of testosterone makes administration of exogenous GnRH a concern in sports doping control. Detection of GnRH abuse is challenging owing to its rapid clearance from the body and degradation in urine. Following recent investigations of GnRH abuse in racing greyhounds in New Zealand, we carried out a GnRH administration study in greyhounds in an attempt to identify GnRH metabolites that might provide more facile detection of GnRH abuse; little information is available on in vivo metabolites of exogenous GnRH in any species and none in dogs...
January 14, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28087972/lack-of-effect-of-oral-cabotegravir-on-the-pharmacokinetics-of-a-levonorgestrel-ethinyl-estradiol-containing-oral-contraceptive-in-healthy-adult-females
#18
C Trezza, S L Ford, E Gould, Y Lou, C Huang, J M Ritter, A M Buchanan, W Spreen, P Patel
AIM(S): This study aimed to investigate whether cabotegravir (CAB), an integrase inhibitor in development for treatment and prevention of HIV-1, influences the pharmacokinetics (PK) of a levonorgestrel (LNG) and ethinyl estradiol (EE)-containing oral contraceptive (OC) in healthy women. METHODS: In this open-label, fixed-sequence crossover study, healthy female subjects received LNG 0.15 mg/EE 0.03 mg tablet once daily Days 1-10 alone and with oral CAB 30 mg once daily Days 11-21...
January 14, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28086977/people-living-with-hiv-on-art-have-accurate-perception-of-lipodystrophy-signs-a-cross-sectional-study
#19
Paulo R Alencastro, Nemora T Barcellos, Fernando H Wolff, Maria Letícia R Ikeda, Fabiana Schuelter-Trevisol, Ajácio B M Brandão, Sandra C Fuchs
BACKGROUND: The prevalence of lipodystrophy ranges from 31 to 65%, depending on the criteria adopted for diagnosis. The usual methods applied in the diagnosis vary from self-perception, medical examination, skinfolds measurements, or even imaging assessment for confirmation of fat distribution changes. Although several methods have been developed, there is no gold standard for characterization of LA and LH, or mixed forms. This study aimed to compare self-reported signs of lipodystrophy with objective measures by skinfolds and circumferences, and to evaluate the prevalence of lipoatrophy (LA) and lipohypertrophy (LH) among subjects living with HIV/AIDS on ART...
January 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28078843/association-between-expression-of-cumulus-expansion-markers-and-real-time-proliferation-of-porcine-follicular-granulosa-cells-in-a-primary-cell-culture-model
#20
S Ciesiółka, J Budna, A Bryja, W Kranc, A Chachuła, M Dyszkiewicz-Konwińska, H Piotrowska, D Bukowska, P Antosik, M Bruska, K P Brüssow, M Nowicki, M Zabel, B Kempisty
Folliculogenesis is a compound process that involves both ovarian follicle growth and oocyte development, which is tightly attached to the follicular wall. During this process, cells that form the follicle structure undergo substantial morphological and molecular modifications that finally lead to differentiation and specialization of ovarian follicular cells. The differentiation of ovarian cells encompasses formation of follicle, which is composed of theca (TCs), mural granulosa (GCs), and cumulus cells (CCs)...
October 2016: Journal of Biological Regulators and Homeostatic Agents
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