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https://www.readbyqxmd.com/read/29165725/somatotrope-pituitary-function-in-professional-soccer-players
#1
Pia Roser, Tatiana Wehrhahn, Henry Krogmann, Nina Riedel, Robert Percy Marshall, Justus Gille, Jörg Flitsch, Jens Aberle
Background and objective Soccer is associated with repetitive head trauma, which, as it is known from sports like football and boxing, can result in hypopituitarism. Gonadotropins and GH are the most common pituitary hormones to become deficient. GH deficiency is associated with an increased risk of cardiovascular mortality and has negative influence on body mass index, visceral fat mass, insulin resistance and sensitivity, bone mineral density and inflammatory markers. Therefore the aim of this study was to evaluate the somatotrope pituitary function in professional soccer players...
November 17, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29165613/exposure-to-concentrated-ambient-pm2-5-compromises-spermatogenesis-in-a-mouse-model-role-of-suppression-of-hypothalamus-pituitary-gonads-axis
#2
Lianglin Qiu, Minjie Chen, Xiaoke Wang, Xiaobo Qin, Sufang Chen, Yingyun Qian, Zhenzhen Liu, Qi Cao, Zhekang Ying
Background: Epidemiological studies link ambient fine particulate matter (PM2.5) pollution to abnormalities in the male reproductive system. However, few toxicological studies have investigated this potentially important adverse effect of PM2.5 pollution. Therefore, in the present study, we analyzed the effects of PM2.5 exposure on spermatogenesis and hypothalamic-pituitary- gonadal (HPG) axis in a murine model. Methods: Fourteen male C57BL/6J mice were subjected to a 4-month exposure to filtered air (FA) or concentrated ambient PM2...
November 20, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29165147/enterococcus-hirae-biofilm-formation-on-hospital-material-surfaces-and-effect-of-new-biocides
#3
Silvia Di Lodovico, Valentina Cataldi, Emanuela Di Campli, Elisabetta Ancarani, Luigina Cellini, Mara Di Giulio
BACKGROUND: Nowadays, the bacterial contamination in the hospital environment is of particular concern because the hospital-acquired infections (HAIs), also known as nosocomial infections, are responsible for significant morbidity and mortality. This work evaluated the capability of Enterococcus hirae to form biofilm on different surfaces and the action of two biocides on the produced biofilms. METHODS: The biofilm formation of E. hirae ATCC 10541 was studied on polystyrene and stainless steel surfaces through the biomass quantification and the cell viability at 20 and 37 °C...
August 2, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29164652/cerium-oxide-nanoparticle-elicits-oxidative-stress-endocrine-imbalance-and-lowers-sperm-characteristics-in-testes-of-balb-c-mice
#4
O A Adebayo, O Akinloye, O A Adaramoye
The toxicity of metallic nanoparticles is a growing concern due to its application in industries and homes. We investigated the toxicity of cerium oxide nanoparticles (CeO2 NPs) on reproductive system in male balb/c mice. Twenty mice were divided into four groups of five animals each and treated thus: normal saline (control), 100, 200 and 300 μg/kg CeO2 NPs (i.p.,) thrice in a week for five consecutive weeks. Results showed that CeO2 NPs significantly reduced the levels of haemoglobin, PCV and RBC count relative to controls...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29163358/reactive-oxygen-species-link-gonadotropin-releasing-hormone-receptor-signaling-cascades-in-the-gonadotrope
#5
Tomohiro Terasaka, Mary E Adakama, Song Li, Taeshin Kim, Eri Terasaka, Danmei Li, Mark A Lawson
Biological rhythms lie at the center of regulatory schemes that control many aspects of living systems. At the cellular level, meaningful responses to external stimuli depend on propagation and quenching of a signal to maintain vigilance for subsequent stimulation or changes that serve to shape and modulate the response. The hypothalamus-pituitary-gonad endocrine axis that controls reproductive development and function relies on control through rhythmic stimulation. Central to this axis is the pulsatile stimulation of the gonadotropes by hypothalamic neurons through episodic release of the neuropeptide gonadotropin-releasing hormone...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29162648/biological-age-of-the-endometrium-using-dna-methylation
#6
Mia S Olesen, Anna Starnawska, Jonas Bybjerg-Grauholm, Alexandra P Bielfeld, Inge E Agerholm, Axel Forman, Michael T Overgaard, Mette Nyegaard
Age has a detrimental effect on reproduction and as an increasing number of women postpone motherhood, it is imperative to assess biological age in terms of fertility prognosis and optimizing fertility treatment individually. Horvath's epigenetic clock is a mathematical algorithm that calculates the biological age of human cells, tissues or organs based on DNA methylation levels. The clock however, was previously shown to be highly inaccurate for the human endometrium, most likely because of the hormonal responsive nature of this tissue...
November 21, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29162314/clinical-characteristics-and-outcomes-of-nonurothelial-cell-carcinoma-of-the-bladder-results-from-the-national-cancer-data-base
#7
Trevor J Royce, Chun C Lin, Phillip J Gray, William U Shipley, Ahmedin Jemal, Jason A Efstathiou
OBJECTIVES: To determine the clinical characteristics, treatment patterns, and outcomes of patients with nonurothelial cell bladder cancer (NUBC) in the United States. METHODS: A total of 163,683 patients with bladder cancer from 1998 to 2014 in the National Cancer Data Base were identified. Of all, 153,262 had urothelial cell (UC) carcinoma (93.6%) and 10,421 had NUBC (6.4%) further classified as: squamous cell carcinoma (SC, 2.4%), adenocarcinoma (AC, 1.7%), neuroendocrine (NE, 1...
November 18, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29161637/la-donna-%C3%A3-mobile-lack-of-cyclical-shifts-in-facial-symmetry-and-facial-and-body-masculinity-preferences-a-hormone-based-study
#8
Urszula M Marcinkowska, Andrzej Galbarczyk, Grazyna Jasienska
Although under investigation for more than two decades, a common agreement on the occurrence of cyclical shifts in women's masculinity and symmetry preferences is still missing. Such shifts are considered to be an important feature of sexual selection as they supposedly direct women's attention towards cues for "good genes" (e.g. masculinity and symmetry) during times when probability of conception is the highest. Multiple studies have, however, failed to find these shifts. We attempt to address this lack of agreement analysing a sample of 110 healthy women, using intra-participant design and repeated measurements of oestradiol and LH during the cycle...
November 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29157942/expression-of-two-glycoprotein-hormone-receptors-in-larval-parasitic-phase-and-adult-sea-lampreys
#9
Krist N Hausken, Timothy J Marquis, Stacia A Sower
All jawed vertebrates have three canonical glycoprotein hormones (GpHs: luteinizing hormone, LH; follicle stimulating hormone, FSH; and thyroid stimulating hormone, TSH) with three corresponding GpH receptors (GpH-Rs: LH-R, FSH-R and TSH-R). In contrast, we propose that the jawless vertebrate, sea lamprey (Petromyzon marinus), only has two pituitary glycoprotein hormones, lamprey (l)GpH and l-thyrostimulin, and two functional glycoprotein receptors, lGpH-R I and II. It is not known at this time whether there is a specific receptor for lGpH and l-thyrostimulin, or if both GpHs can differentially activate the lGpH-Rs...
November 17, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29156341/urinary-bisphenol-a-concentrations-are-associated-with-reproductive-parameters-in-young-men
#10
Evdochia Adoamnei, Jaime Mendiola, Fernando Vela-Soria, Mariana F Fernández, Nicolás Olea, Niels Jørgensen, Shanna H Swan, Alberto M Torres-Cantero
Bisphenol A (BPA) is a pervasive environmental toxicant with known reproductive effects on sperm parameters and hormone levels. Several observational studies have investigated the associations between BPA exposure and male reproductive function, but findings are inconsistent. The objective of this study was to assess the associations between urinary BPA concentrations and semen quality and reproductive hormone levels in a cross-sectional study with 215 healthy young university students (18-23 years old), investigated between 2010 and 2011 in Southern Spain (Murcia Region)...
November 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/29155993/lack-of-antidepressant-effects-of-2r-6r-hydroxynorketamine-in-a-rat-learned-helplessness-model-comparison-with-r-ketamine
#11
Yukihiko Shirayama, Kenji Hashimoto
Background: (R)-Ketamine exhibits rapid and sustained antidepressant effects in animal models of depression. It is stereoselectively metabolized to (R)-norketamine, and subsequently to (2R,6R)-hydroxynorketamine (HNK) in the liver. The metabolism of ketamine to HNK was recently demonstrated to be essential for ketamine's antidepressant actions. However, no study has compared the antidepressant effects of these three compounds in animal models of depression. Methods: The effects of a single intraperitoneal injection of (R)-ketamine, (R)-norketamine, and (2R,6R)-HNK in a rat learned helplessness (LH) model were examined...
November 15, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29155569/redox-behavior-of-a-dinuclear-ruthenium-ii-complex-bearing-an-uncommon-bridging-ligand-insights-from-high-pressure-electrochemistry
#12
Maximilian Dürr, Johannes Klein, Axel Kahnt, Sabine Becker, Ralph Puchta, Biprajit Sarkar, Ivana Ivanović-Burmazović
A dinuclear ruthenium complex bridged by 2,3,5,6-pyrazinetetracarboxylic acid (μ-LH2(2-)) was synthesized and characterized by X-ray crystallography, cyclic voltammetry under ambient and elevated pressures, electron paramagnetic resonance (EPR) and UV/vis-NIR (NIR = near-infrared) spectroelectrochemistry, pulse radiolysis, and computational methods. We probed for the first time in the field of mixed-valency the use of high-pressure electrochemical methods. The investigations were directed toward the influence of the protonation state of the bridging ligand on the electronic communication between the ruthenium ions, since such behavior is interesting in terms of modulating redox chemistry by pH...
November 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29154933/opioid-prescription-and-patient-use-following-gynecologic-procedures-a-survey-of-patients-and-providers
#13
Kendall C Griffith, Nisse V Clark, Andrea L Zuckerman, Tanaz R Ferzandi, Kelly N Wright
STUDY OBJECTIVE: To describe opioid distribution and patient use following gynecologic procedures. DESIGN: This is a survey study of physicians and patients composed of two parts: 1) a physician survey on opioid prescribing practices following gynecologic procedures, and 2) a patient survey on opioid consumption following hysterectomy. DESIGN CLASSIFICATION: III SETTING: An urban academic tertiary care hospital. SUBJECTS: 96 gynecologists in the Boston-area...
November 14, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29153058/induction-of-the-lh-surge-in-premenarchal-girls-confirms-early-maturation-of-the-hypothalamic-pituitary-ovarian-axis
#14
Polina Rovner, Julia Keltz, Amanda Allshouse, Barbara Isaac, Cheryl Hickmon, Jennifer Lesh, Justin Chosich, Nanette Santoro
PURPOSE: To determine whether premenarchal girls exhibit positive estradiol feedback similar to regularly cycling adult women when given exogenous estradiol. METHODS: This was a prospective clinical cohort study at 2 institutions. Nine girls and 6 women received a 7-day course of transdermal estradiol designed to produce physiologic, mid-cycle circulating estradiol levels. Participants collected daily morning urine for luteinizing hormone (LH), estradiol metabolites (E1c), and progesterone metabolites (Pdg), corrected for creatinine...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29152085/the-effect-of-human-chorionic-gonadotrophin-contained-in-human-menopausal-gonadotropin-on-the-clinical-outcomes-during-progestin-primed-ovarian-stimulation
#15
Xiuxian Zhu, Jing Ye, Yonglun Fu, Ai Ai, Renfei Cai, Yun Wang, Qingging Hong, Tian Hui, Qifeng Lyu, Qiuju Chen, Yanping Kuang
Progestin-primed ovarian stimulation (PPOS) protocol has recently been demonstrated to be an novel regimen for preventing premature LH surges during controlled ovarian hyperstimulation (COH) in combination with frozen-thawed embryo transfer (FET). Our prospective controlled study was to explore the effect of human chorionic gonadotropin (hCG) contained in human menopausal gonadotropin (hMG) on the clinical outcomes in normalovulatory women undergoing COH with PPOS. A total of 180 patients were allocated into three groups according to the gonadotropin (Gn) used: group A (human menopausal gonadotropin, hMG-A), group B (hMG-B) or group C (follicle stimulating hormone, FSH)...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151391/repeated-treatment-with-nitric-oxide-synthase-inhibitor-attenuates-learned-helplessness-development-in-rats-and-increases-hippocampal-bdnf-expression
#16
Laura Alves Stanquini, Caroline Biojone, Francisco Silveira Guimarães, Sâmia Regiane Joca
BACKGROUND: Nitric oxide synthase (NOS) inhibitors induce antidepressant-like effects in animal models sensitive to acute drug treatment such as the forced swimming test. However, it is not yet clear if repeated treatment with these drugs is required to induce antidepressant-like effects in preclinical models. OBJECTIVE: The aim of this study was to test the effect induced by acute or repeated (7 days) treatment with 7-nitroindazole (7-NI), a preferential inhibitor of neuronal NOS, in rats submitted to the learned helplessness (LH) model...
November 20, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29150338/impacts-of-prenatal-triclosan-exposure-on-fetal-reproductive-hormones-and-its-potential-mechanism
#17
Caifeng Wang, Limei Chen, Shasha Zhao, Yi Hu, Yijun Zhou, Yu Gao, Weiye Wang, Jun Zhang, Ying Tian
BACKGROUND: Triclosan (TCS) has been widely detected in pregnant women. The reproductive endocrine-disrupting effects of TCS have been observed in humans and animals. Little is known about the potential impact of prenatal TCS exposure on fetal reproductive development as well as its potential mechanism. OBJECTIVES: We investigated the potential effect of prenatal TCS exposure on fetal reproductive hormones in cord blood and its potential mechanism in relation to placental steroidogenic enzymes...
November 14, 2017: Environment International
https://www.readbyqxmd.com/read/29149676/high-salt-diet-decreases-reproductive-performance-in-rams-and-down-regulates-gene-expression-of-some-components-of-the-renin-angiotensin-system-in-the-testis
#18
Yi Fang, Rongzhen Zhong, Xuezhao Sun, Daowei Zhou
Although salt-tolerant plants can be used to combat dryland salinity, these plants contain high concentrations of salt (NaCl), which may have deleterious effects if fed to livestock. Twenty-four Merino rams (9 mo of age) with similar body weight were equally allocated to two groups and fed a normal- or high-salt diet (0.5 and 12% NaCl, respectively) for 3 mo. Rams fed the high-salt diet had lower live weight gains, higher water intake, smaller testes (466 ± 48.4 vs 604 ± 51.1 g) and reductions (P <0...
November 10, 2017: Theriogenology
https://www.readbyqxmd.com/read/29149324/pyrethroid-insecticide-cypermethrin-modulates-gonadotropin-synthesis-via-calcium-homeostasis-and-erk1-2-signaling-in-l%C3%AE-t2-mouse-pituitary-cells
#19
Feixue Li, Huihui Ma, Jing Liu
Pyrethroids are a class of widely used insecticides. Cypermethrin (CP) is one of most commonly used pyrethroid insecticides and its residue has been frequently detected in environmental media. Our recent animal study reported that early postnatal exposure to CP induced an increase in serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) as well as the expression of gonadotropin subunit genes [chorionic gonadotropin α (CGα), LHβ and FSHβ] in pituitary tissues. In this study, we further investigated the precise mechanism by which CP at concentrations of 1-100 nM affected the synthesis of gonadotropins using a murine pituitary gonadotropic cell line LβT2...
November 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29148981/walnut-leaf-extract-acts-as-a-fertility-agent-in-male-wistar-albino-rats-a-search-for-herbal-male-fertility-enhancer
#20
Seun F Akomolafe, Ganiyu Oboh
Background Walnut leaf is one of the many medicinal plants used in folklore as male fertility enhancers. The present work was therefore undertaken with an aim to scientifically validate this claim. As such, we evaluated the effect of the aqueous extract from walnut leaves on biomolecules related to fertility in adult male rats and its mode of action as fertility-enhancing agent. Methods Twenty-five rats were randomly divided into five groups of five animals each; Group 1 served as control and received normal (0...
November 17, 2017: Journal of Complementary & Integrative Medicine
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