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https://www.readbyqxmd.com/read/29036809/role-of-fshr-rs6165-and-esr2-rs4986938-polymorphisms-in-ovarian-stimulation-of-iranian-women-who-underwent-assisted-reproduction-treatment
#1
Maryam Kaviani, Sayyed Mohammad Hossein Ghaderian, Soheila Arefi, Mehrdad Hashemi, Sarah Sadat Aghabozorg Afjeh
BACKGROUND: Gonadotropin therapy was used to stimulate the ovary in infertile women who underwent assisted reproduction treatment (ART). Numerous studies indicated that infertile women showed different responses to gonadotropin therapy. Follicle stimulating hormone receptor (FSHR) and Oestrogen receptor (ER) polymorphisms have been reported to involve induction of folliculogenesis and ovarian response to treatment. METHODS: In the present study, two polymorphisms, namely FSHR rs6165 and ESR2 rs4986938, were investigated in 198 Iranian infertile women aged less than 39 years who underwent ART...
September 29, 2017: Human Antibodies
https://www.readbyqxmd.com/read/29036567/extra-pituitary-expressed-fsh-is-it-physiologically-important
#2
Anushka Jayaraman, T Rajendra Kumar
Pituitary gonadotropes synthesize and secrete follicle-stimulating hormone (FSH). FSH is a heterodimer that consists of an α-and a β-subunit. The α - subunit is common to other pituitary and placental glycoprotein hormones and the β-subunit is the hormone/receptor specific subunit. Although the pituitary is the main tissue that accounts for circulating hormone, previous and recent reports indicate extra-pituitary sources of FSH production including mouse gonads, human stomach, prostate, umbilical cord vein endothelial cells, uterine myometrium, placenta and chicken abdominal adipose tissue...
September 20, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29033405/construction-and-expression-of-vectors-encoding-biologically-active-rodent-gonadotropins
#3
Akihiko Ohta, Yuichiro Tsunoda, Yoshihiko Tamura, Kayoko Iino, Naoto Nishimura, Hiroto Nishihara, Haruka Takanashi, Saishu Yoshida, Takako Kato, Yukio Kato
The gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are important hormones in vertebrate reproduction. The isolation of gonadotropins from the pituitary gland is sub-optimal, as the cross-contamination of one hormone with another is common and often results in the variation in the measured activity of LH and FSH. The production of recombinant hormones is, therefore, a viable approach to solve this problem. This study aimed to express recombinant rat, mouse, and mastomys FSH and LH in Chinese hamster ovary (CHO) cells...
October 13, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29031924/evaluation-of-cervical-mucus-and-reproductive-efficiency-of-seasonally-anovular-dairy-goats-after-short-term-progestagen-based-estrous-induction-protocols-with-different-gonadotropins
#4
Jeferson F Fonseca, Joanna M G Souza-Fabjan, Maria Emilia F Oliveira, Renata C Cruz, Luciana V Esteves, Maria Pia S L Matos de Paiva, Felipe Z Brandão, Antônio B Mancio
The use of three different gonadotropins was tested for estrous induction in dairy goats during the non-breeding season. All does received an injection of 30 μg of d-cloprostenol and intravaginal sponges containing 60mg of medroxyprogesterone acetate (MAP) for 6 d plus 20 IU of porcine FSH (pFSH), 200 IU of eCG or 250 IU of hCG 24h before sponge removal. In Experiment 1 (n=24), ovarian ultrasound parameters were recorded and cervical mucus was evaluated daily for 5 d after sponge removal or until ovulation...
October 11, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29030685/combined-effects-of-varicocele-and-cell-phones-on-semen-and-hormonal-parameters
#5
Ingrid Schauer, Badereddin Mohamad Al-Ali
BACKGROUND: The objective of this study was to evaluate if there is a combined effect of varicocele and cell phone storage in trousers pockets on semen and hormonal parameters. METHODS: A retrospective analysis of 468 men attending an infertility clinic from 1993-2007 was performed. Varicoceles were determined by clinical examination and patients were questioned on cell phone usage and storage fashion. Semen samples were analyzed according to the World Health Organization (WHO) guidelines of 1999...
October 13, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29030126/the-pesticide-lindane-induces-dose-dependent-damage-to-granulosa-cells-in-an-in-vitro-culture
#6
Maria Grazia Palmerini, Gulmira Zhurabekova, Aru Balmagambetova, Stefania Annarita Nottola, Selenia Miglietta, Manuel Belli, Serena Bianchi, Sandra Cecconi, Valentina Di Nisio, Giuseppe Familiari, Guido Macchiarelli
Lindane, which is one of the most persistent organochlorine pesticide contaminating the Aral Sea region, is associated with numerous pathologies of the female reproductive system, including infertility, due to its gap junction blocker activity. By using an in vitro model of reproductive toxicity consisting of mouse parietal granulosa cells (GCs) exposed to increasing concentrations of Lindane ranging from 1 to 100μM (L1; L10; L100), we aimed to ascertain the Lindane toxicity by evaluating the ultrastructure and expression of the cell death protein p53...
October 10, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29029246/the-epidermal-growth-factor-network-role-in-oocyte-growth-maturation-and-developmental-competence
#7
Dulama Richani, Robert B Gilchrist
BACKGROUND: The LH surge induces great physiological changes within the preovulatory follicle, which culminate in the ovulation of a mature oocyte that is capable of supporting embryo and foetal development. However, unlike mural granulosa cells, the oocyte and its surrounding cumulus cells are not directly responsive to LH, indicating that the LH signal is mediated by secondary factors produced by the granulosa cells. The mechanisms by which the oocyte senses the ovulatory LH signal and hence prepares for ovulation has been a subject of considerable controversy for the past four decades...
September 20, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29029242/germ-cell-neoplasia-in-situ-and-preserved-fertility-despite-suppressed-gonadotropins-in-a-patient-with-testotoxicosis
#8
Li Juel Mortensen, Martin Blomberg Jensen, Peter Christiansen, Ann-Margrethe Rønholt, Anne Jørgensen, Hanne Frederiksen, John E Nielsen, Anand C Loya, Birgitte Grønkær Toft, Niels E Skakkebæk, Ewa Rajpert-De Meyts, Anders Juul
Context: Testotoxicosis is an autosomal dominant, male-limited disorder. Activating mutations in the Luteinizing Hormone Receptor gene (LHCGR) cause high autonomous testosterone secretion resulting in early-onset peripheral precocious puberty. Little is known about long-term consequences of testotoxicosis. Case Description: We present a rare case of a patient followed for 25 years with two remarkable outcomes; preserved fertility and germ cell neoplasia in situ (GCNIS)...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29026709/needle-aspiration-biopsy-of-seminiferous-tubules-nabst-as-a-diagnostic-method-in-korea
#9
Jay Ho Jung, Tae Ho Lee, Kyung Hwa Choi, Jae Yup Hong
To evaluate the diagnostic efficacy of needle aspiration biopsy of seminiferous tubules (NABST) and to represent the redistributed diagnostic results corresponding to testicular volumes and follicle-stimulating hormone (FSH) levels. In this retrospective study, we investigated 65 infertile men with either azoospermia or oligoasthenoteratozoospermia. Following NABST, specimens were stained with hematoxylin and eosin and classified into five histological types. With pre-procedure FSH levels and testicular volumes, we evaluated the probabilities of detecting sperms within biopsy specimens...
September 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/29025019/differing-molecular-response-of-young-and-advanced-maternal-age-human-oocytes-to-ivm
#10
J M Reyes, E Silva, J L Chitwood, W B Schoolcraft, R L Krisher, P J Ross
STUDY QUESTION: What effect does maternal age have on the human oocyte's molecular response to in vitro oocyte maturation? SUMMARY ANSWER: Although polyadenylated transcript abundance is similar between young and advanced maternal age (AMA) germinal vesicle (GV) oocytes, metaphase II (MII) oocytes exhibit a divergent transcriptome resulting from a differential response to in vitro oocyte maturation. WHAT IS KNOWN ALREADY: Microarray studies considering maternal age or maturation stage have shown that either of these factors will affect oocyte polyadenylated transcript abundance in human oocytes...
September 15, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29024968/iron-suppresses-ovarian-granulosa-cell-proliferation-and-arrests-cell-cycle-through-regulating-p38-mapk-p53-p21-pathway
#11
Mei-Jou Chen, Chia-Hong Chou, Chia-Tung Shun, Tsui-Lien Mao, Wen-Fen Wen, Chin-Der Chen, Shee-Uan Chen, Yu-Shih Yang, Hong-Nerng Ho
Iron is an essential nutrient that may exert toxic effects when it accumulates in tissues. Little is known regarding its effects on gonadal function. Both Fe2+ and Fe3+ could be released from iron deposition. We employed mouse non-luteinized granulosa cell for in vitro studies and human ovarian tissues for Prussian blue and immunohistochemical staining to identify the iron deposition and effect in vivo. After treatment with FeSO4-7H2O or FeCl3 in granulosa cell cultured with follicle stimulating hormone (FSH) for 48 hours, we found that Fe2+ significantly suppressed FSH-induced granulosa cell proliferation and arrested the cell cycle at the G2/M phase by cell proliferation assay and flow cytometry...
August 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29017919/whole-cell-biopanning-with-a-synthetic-phage-display-library-of-nanobodies-enabled-the-recovery-of-follicle-stimulating-hormone-receptor-inhibitors
#12
Ronan Crepin, Gianluca Veggiani, Selma Djender, Anne Beugnet, François Planeix, Christophe Pichon, Sandrine Moutel, Sebastian Amigorena, Franck Perez, Nicolae Ghinea, Ario de Marco
Antibodies are essential reagents that are increasingly used in diagnostics and therapy. Their specificity and capacity to recognize their native antigen are critical characteristics for their in vivo application. Follicle-stimulating hormone receptor is a GPCR protein regulating ovarian follicular maturation and spermatogenesis. Recently, its potentiality as a cancer biomarker has been demonstrated but no antibody suitable for in vivo tumor targeting and treatment has been characterized so far. In this paper we describe the first successful attempt to recover recombinant antibodies against the FSHR and that: i) are directly panned from a pre-immune library using whole cells expressing the target receptor at their surface; ii) show inhibitory activity towards the FSH-induced cAMP accumulation; iii) do not share the same epitope with the natural binder FSH; iv) can be produced inexpensively as mono- or bivalent functional molecules in the bacterial cytoplasm...
October 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29016685/lactobacillus-rhamnosus-pb01-dsm-14870-supplementation-affects-markers-of-sperm-kinematic-parameters-in-a-diet-induced-obesity-mice-model
#13
Fereshteh Dardmeh, Hiva Alipour, Parisa Gazerani, Gerhard van der Horst, Erik Brandsborg, Hans Ingolf Nielsen
Probiotics have been proposed as alternatives to pharmacological products in several medical conditions including the modulation of obesity, which is frequently associated with poor semen quality. However, effects of probiotics on male fertility have been less investigated. This study assessed the effect of Lactobacillus rhamnosus PB01 (DSM-14870) on sperm kinematic parameters in Normal-weight (NW) and diet-induced obese (DIO) models. NW and DIO C57BL/6NTac mice were divided into two subgroups with or without a single daily dose (1x109CFU) of L...
2017: PloS One
https://www.readbyqxmd.com/read/28993982/comparative-assessment-on-the-expression-level-of-recombinant-human-follicle-stimulating-hormone-fsh-in-serum-containing-versus-protein-free-culture-media
#14
Seyedeh Hoda Jazayeri, Amir Amiri-Yekta, Hamid Gourabi, Baharak Abd Emami, Zahra Halfinezhad, Somayeh Abolghasemi, Nayeralsadat Fatemi, Abbas Daneshipour, Mohammad Hossein Ghahremani, Mohammad Hossein Sanati, Mohammad Reza Khorramizadeh
Production of recombinant pharmaceutical proteins has made a great contribution to modern biotechnology. At present, quick advances in protein expression lead to the enhancement of product quantity and quality as well as reduction in timescale processing. In the current study, we assessed the expression level of recombinant human follicle-stimulating hormone (rhFSH) in adherent and suspension Chinese hamster ovary (CHO) cell lines by cultivation in serum-containing and chemically defined, protein-free media...
October 9, 2017: Molecular Biotechnology
https://www.readbyqxmd.com/read/28993599/circulating-gonadotropins-and-testicular-hormones-during-sexual-maturation-and-annual-changes-in-male-bottlenose-dolphins-tursiops-truncatus
#15
Etsuko Katsumata, Sukanya Jaroenporn, Yoko Ueda, Kazutoshi Arai, Hiroshi Katsumata, Gen Watanabe, Kazuyoshi Taya
To reveal the reproductive biology in male bottlenose dolphins (Tursiops truncatus), circulating gonadotropins (follicle stimulating hormone [FSH] and luteinizing hormone [LH]) and testicular hormones (testosterone and inhibin) were monitored for 8 -12 years in 2 captive bottlenose dolphins (Mars and Regulus). During the study period, Mars was undergoing sexual maturation, whereas Regulus was already mature at the beginning of the study. Assuming that Mars had reached sexual maturity when the significant increase in circulating testosterone levels was observed, serum concentration of inhibin was higher in the sexually immature stage than in the mature stage, whereas the serum concentration of FSH was higher in the sexually mature stage than in the immature stage...
October 7, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28992366/possible-involvement-of-the-glucocorticoid-receptor-nr3c1-and-selected-nr3c1-gene-variants-in-regulation-of-human-testicular-function
#16
L Nordkap, K Almstrup, J E Nielsen, A K Bang, L Priskorn, M Krause, S A Holmboe, S B Winge, D L Egeberg Palme, N Mørup, J H Petersen, A Juul, N E Skakkebaek, E Rajpert-De Meyts, N Jørgensen
Perceived stress has been associated with decreased semen quality but the mechanisms have not been elucidated. It is not known whether cortisol, the major stress hormone in humans, can act directly via receptors in the testis, and whether variants in the gene encoding the glucocorticoid receptor (NR3C1) can possibly modulate the effect. To address these questions, we investigated the expression of the glucocorticoid receptor in human testicular tissue, including adult and fetal samples (n = 20) by immunohistochemical staining, and in silico analysis of publicly available datasets...
October 9, 2017: Andrology
https://www.readbyqxmd.com/read/28989885/impact-of-severity-of-illness-on-the-function-of-the-hypothalamo-pituitary-gonadal-axis-in-postmenopausal-women-with-acute-severe-illness-implications-for-predicting-disease-outcome
#17
Suresh Vaikkakara, Marella Neelima Raj, Alok Sachan, Alladi Mohan, Bhuma Vengamma, P V L N Srinivas Rao, Arun Mukka, Chiruvella Sravani, Amaresh P Reddy
BACKGROUND: While elevated levels of estradiol were predictive of mortality in critically ill surgical and trauma patients, their ability to predict outcome in nonsurgical patients has not been studied. We aimed to study the determinants of gonadotropin levels in acutely ill postmenopausal women with nonsurgical disease and the impact of changes in the gonadal axis on the outcome of these patients. METHODS: Thirty-five postmenopausal women admitted to medical intensive care with acute severe illness and having a Simplified Acute Physiology Score (SAPS II score) ≥30 (in-hospital mortality rate ≥ 10%) were recruited...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28989874/metabolic-status-and-hypogonadism-in-human-immunodeficiency-virus-infected-males
#18
Sarita Bajaj, Yashaswi Pathak, Sharad Varma, Sujit Verma
AIMS AND OBJECTIVES: The aim of this study is to determine the prevalence of hypogonadism in human immunodeficiency virus (HIV)-infected males and to study its relation to age, CD4 count, body mass index (BMI), duration of highly active antiretroviral therapy (HAART), and metabolic status. METHODOLOGY: Eighty-one HIV positive cases and 82 healthy controls were included in this case-control study. Each case underwent a complete physical examination and serum fasting plasma glucose, A1c, lipid profile, total testosterone (TT), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels were estimated...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28986927/effects-of-phyto-oestrogen-quercetin-on-productive-performance-hormones-reproductive-organs-and-apoptotic-genes-in-laying-hens
#19
J X Yang, M T Chaudhry, J Y Yao, S N Wang, B Zhou, M Wang, C Y Han, Y You, Y Li
Quercetin, a polyphenolic flavonoid with diverse biological activities including anti-inflammatory and antiviral, inhibits lipid peroxidation, prevents oxidative injury and cell death. The purpose of the research was to investigate the effect of quercetin on productive performance, reproductive organs, hormones and apoptotic genes in laying hens between 37 and 45 weeks of age, because of the structure and oestrogenic activities similar to 17β-oestradiol. The trial was conducted using 240 Hessian laying hens (37 weeks old), housed in wire cages with two hens in each cage...
October 6, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28986734/antral-follicle-responsiveness-to-fsh-assessed-by-the-follicular-output-rate-fort-is-altered-in-hodgkin-s-lymphoma-when-compared-with-breast-cancer-candidates-for-fertility-preservation
#20
Charlotte Sonigo, Marjorie Comtet, Solene Duros, Christophe Sifer, Nathalie Sermondade, Michaël Grynberg
PURPOSE: Oocyte and/or embryo cryopreservation after controlled ovarian hyperstimulation (COH) represents the most established method for female fertility preservation (FP) before cancer treatment. Whether patients suffering from malignancies, candidates for FP, have a normal ovarian capacity to respond to stimulation is controversial. Reduced responsiveness of antral follicle to exogenous FSH might be at play. The percentage of antral follicles that successfully respond to FSH administration may be estimated by the follicular output rate (FORT), which presumably reflects the health of granulosa cells...
October 6, 2017: Journal of Assisted Reproduction and Genetics
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