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https://www.readbyqxmd.com/read/29445430/seizure-prophylaxis-in-the-immediate-post-hemorrhagic-period-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#1
Thomas V Kodankandath, Salman Farooq, Wled Wazni, John-Andrew Cox, Christopher Southwood, Gregory Rozansky, Vijay Johnson, John R Lynch
Introduction: Seizures are a well-known complication of aneurysmal subarachnoid hemorrhage (aSAH) and occur most commonly in the immediate posthemorrhagic period. Most commonly used antiepileptic drugs (AEDs) for seizure prophylaxis in aSAH include phenytoin and levetiracetam. There is no reliable data available on the safety and efficacy of restricting AED prophylaxis only till the aneurysm is secured. Methods: We retrospectively chart reviewed patients admitted to our neurosciences intensive care unit (NICU) with aSAH during the past two years...
December 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29425980/dose-dependent-effects-of-statins-for-patients-with-aneurysmal-subarachnoid-hemorrhage-meta-regression-analysis
#2
REVIEW
Minh-Son To, Shivesh Prakash, Santosh I Poonnoose, Shailesh Bihari
OBJECTIVE: The study utilizes meta-regression analysis to quantify the dose-dependent effects of statin pharmacotherapy on vasospasm, delayed ischemic neurologic deficits (DINDs) and mortality in aneurysmal subarachnoid hemorrhage (aSAH). METHODS: Prospective, retrospective observational studies and randomized controlled trials (RCTs) were retrieved by a systematic database search. Summary estimates were expressed as absolute risk (AR) for a given statin dose or control (placebo)...
February 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29410100/association-between-neurological-outcomes-related-to-aneurysmal-subarachnoid-haemorrhage-and-onsite-access-to-neurointerventional-radiology
#3
Jorge Pena Mogollon, Nicolas Roydon Smoll, Rakshit Panwar
OBJECTIVE: An onsite access to neurointerventional radiology (NIR) may be useful for managing patients with aneurysmal subarachnoid haemorrhage (aSAH) after the aneurysm-securing procedure. We aimed to assess the association between neurological outcomes related to aSAH and onsite access to NIR service. METHODS: This was a sequential period study of 47 patients with aSAH admitted consecutively during the pre-NIR period (Jan 2010 to Jun 2012) compared with 81 patients with aSAH admitted consecutively during the post-NIR period (Jan 2013 to Jun 2015) at an academic tertiary referral ICU...
February 1, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29393753/bedside-optical-coherence-tomography-for-terson-s-syndrome-screening-in-acute-subarachnoid-hemorrhage-a-pilot-study
#4
Ciro Ramos-Estebanez, Maryo Kohen, Jonathan Pace, Alireza Bozorgi, Sunil Manjila, Vilakshan Alambyan, Ifeyinwa Nwankwo, Michael DeGeorgia, Nicholas C Bambakidis, Faruk Orge
OBJECTIVE Approximately 10% of patients with subarachnoid hemorrhage (SAH) become permanently, legally blind. The average cost of lifetime support and unpaid taxes for each blind person amounts to approximately $900,000. This study evaluates the feasibility and potential role of bedside optical coherence tomography (OCT) in Terson's syndrome (TS) in patients with acute SAH (aSAH) and its potential role in blindness prevention. METHODS The authors conducted an open-label pilot study, in which 31 patients with an angiographic diagnosis of aSAH were first screened for TS with dilated funduscopy and then with OCT in the acute phase and at 6-week follow-up visits...
February 2, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29355804/continuous-lumbar-cistern-drainage-before-surgical-clipping-for-aneurysmal-subarachnoid-hemorrhage
#5
Ning Xu, Hao Meng, Tianyi Liu, Yingli Feng, Yuan Qi, Honglei Wang
BACKGROUND: Lumbar drainage (LD) is the choice for the treatment of acute hydrocephalus and increased intracranial pressure in patients with subarachnoid hemorrhage (SAH). It also reduces vasospasm risk and delayed ischemic neurological events. We evaluated the role of LD in the preoperative management of patients with aneurysmal SAH (aSAH). PATIENTS AND METHODS: From January 2011 to January 2013, 520 patients with aSAH were subjected to clipping surgery and were prospectively enrolled in this study...
January 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29350603/decision-tree-analysis-in-subarachnoid-hemorrhage-prediction-of-outcome-parameters-during-the-course-of-aneurysmal-subarachnoid-hemorrhage-using-decision-tree-analysis
#6
Isabel Charlotte Hostettler, Carl Muroi, Johannes Konstantin Richter, Josef Schmid, Marian Christoph Neidert, Martin Seule, Oliver Boss, Athina Pangalu, Menno Robbert Germans, Emanuela Keller
OBJECTIVE The aim of this study was to create prediction models for outcome parameters by decision tree analysis based on clinical and laboratory data in patients with aneurysmal subarachnoid hemorrhage (aSAH). METHODS The database consisted of clinical and laboratory parameters of 548 patients with aSAH who were admitted to the Neurocritical Care Unit, University Hospital Zurich. To examine the model performance, the cohort was randomly divided into a derivation cohort (60% [n = 329]; training data set) and a validation cohort (40% [n = 219]; test data set)...
January 19, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29335395/predictors-of-recanalization-after-endovascular-treatment-of-posterior-circulation-aneurysms
#7
Karol Wiśniewski, Bartłomiej Tomasik, Ernest J Bobeff, Ludomir Stefańczyk, Dariusz J Jaskólski
INTRODUCTION: Posterior circulation aneurysms account for approximately 30% of all intracranial aneurysms, and their rupture often causes aneurysmal subarachnoid hemorrhage (aSAH). Because surgical treatment of posterior circulation aneurysms is difficult, endovascular treatment is commonly indicated. However, simple coil embolization is associated with a high rate of recanalization. Our goal was to investigate morphometric aneurysmal features assessed on pre-embolization computed tomography angiography (CTA) as predictors of recanalization in patients with posterior circulation aneurysms...
December 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29302799/early-abnormal-transient-hyperemic-response-test-can-predict-delayed-ischemic-neurologic-deficit-in-subarachnoid-hemorrhage
#8
Hosam Al-Jehani, Mark Angle, Judith Marcoux, Jeanne Teitelbaum
BACKGROUND: Early detection of vasospasm is crucial to prevent significant delayed ischemic neurological deficit post subarachnoid hemorrhage. The standard methods of detection, including cerebral angiogram and computed tomography are invasive and not safe to be repeated, as is very often indicated clinically. Transient hyperemic response test has been previously used to predict autoregulation failure in traumatic brain injury and subarachnoid hemorrhage. AIMS: We investigate the usability of transient hyperemic response test as a predictor of clinical vasospasm in a cohort of patients with aneurismal subarachnoid hemorrhage...
January 4, 2018: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/29288108/sexual-dysfunction-after-good-grade-aneurysmal-subarachnoid-hemorrhage
#9
Lorenz Epprecht, Michael Messerli, Robin Samuel, Martin Seule, Johannes Weber, Jean-Yves Fournier, Werner Surbeck
OBJECTIVE: Our aim was to assess the consequences of aneurysmal subarachnoid hemorrhage (aSAH) on sexual pleasure in patients with an otherwise favorable neurological outcome. METHODS: Anonymous, standardized questionnaires concerning sexual function, including the International Index of Erectile Function, Female Sexual Function Index, and a statement on subjective change in sexual pleasure after aSAH, were completed by 33 patients treated at the Cantonal Hospital St...
December 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29288107/memory-deficits-after-aneurysmal-subarachnoid-hemorrhage-an-fmri-study
#10
Jiabin Su, Tongzhou E, Qihao Guo, Yu Lei, Yuxiang Gu
BACKGROUND: Patients suffer from aneurysmal subarachnoid hemorrhage (aSAH) are thought to have cognitive impairment. However, little is known about characteristics of functional imaging in aSAH patients OBJECTIVE: To explore the whole brain activity pattern in aSAH patients using amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC). METHOD: 50 aSAH patients and 30 healthy controls were recruited and subjected to a resting-state functional magnetic resonance imaging scan and cognitive tasks...
December 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29277532/levels-of-il-1%C3%AE-il-18-and-tnf-%C3%AE-in-cerebrospinal-fluid-of-aneurysmal-subarachnoid-hemorrhage-patients-may-be-predictors-of-early-brain-injury-and-clinical-prognosis
#11
Sheng-Yin Lv, Qi Wu, Jing-Peng Liu, Jiang Shao, Li-Li Wen, Jin Xue, Xiang-Sheng Zhang, Qing-Rong Zhang, Xin Zhang
BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) is a severe cerebrovascular accident with high morbidity and mortality. The aim of this study is to investigate the relationship between level of inflammatory cytokines in cerebrospinal fluid of aSAH patients, the severity of aSAH and the outcome of aSAH patients. METHODS: aSAH patients were prospectively included and followed-up 6 months. CSF samples were collected at 1-3 days, 4-6 days and 7-9 days after aSAH onset, respectively...
December 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29274300/unconjugated-bilirubin-modulates-neuronal-signaling-only-in-wild-type-mice-but-not-after-ablation-of-the-r-type-cav-2-3-voltage-gated-calcium-channel
#12
Walid Albanna, Felix Neumaier, Jan Niklas Lüke, Konstantin Kotliar, Catharina Conzen, Ute Lindauer, Jürgen Hescheler, Hans Clusmann, Toni Schneider, Gerrit Alexander Schubert
INTRODUCTION: The relationship between blood metabolites and hemoglobin degradation products (BMHDPs) formed in the cerebrospinal fluid and the development of vasospasm and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) has been the focus of several previous studies, but their molecular and cellular targets remain to be elucidated. METHODS: Because BMHDP-induced changes in Cav 2.3 channel function are thought to contribute to DCI after aSAH, we studied their modulation by unconjugated bilirubin (UCB) in an organotypical neuronal network from wild-type (WT) and Cav 2...
December 23, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29260012/time-courses-of-plasma-il-6-and-hmgb-1-reflect-initial-severity-of-clinical-presentation-but-do-not-predict-poor-neurologic-outcome-following-subarachnoid-hemorrhage
#13
Heikki Kiiski, Jaakko Långsjö, Jyrki Tenhunen, Marika Ala-Peijari, Heini Huhtala, Mari Hämäläinen, Eeva Moilanen, Juha Öhman, Jukka Peltola
Objective: Patients with aneurysmal subarachnoid hemorrhage (aSAH) experience high mortality and morbidity. Neuroinflammation causes brain damage expansion after aSAH. Due to the complexity of the inflammatory response multiple biomarkers are needed to evaluate its' progression. We studied inflammatory process after aSAH by measuring two inflammatory biomarkers, interleukin-6 (IL-6) and high-mobility group box 1 (HMGB1) at simultaneous time-points after aSAH. Methods: In this prospective population-based study, IL-6 and HMGB1 were measured in aSAH patients (n = 47) for up to five days...
March 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29258940/predictors-of-occurrence-and-anatomic-distribution-of-multiple-aneurysms-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#14
Michel Roethlisberger, Rita Achermann, Schatlo Bawarjan, Martin N Stienen, Christian Fung, Donato D'Alonzo, Nicolai Maldaner, Andrea Ferrari, Marco V Corniola, Daniel Schöni, Daniele Valsecchi, Rodolfo Maduri, Martin A Seule, Jan-Karl Burkhardt, Serge Marbacher, Philippe Bijlenga, Kristine A Blackham, Heiner C Bucher, Luigi Mariani, Raphael Guzman, Daniel W Zumofen
BACKGROUND: The literature on multiple intracranial aneurysms (MIA) in patients with aneurysmal subarachnoid hemorrhage (aSAH) focuses largely on risk factor analysis and consists essentially of retrospective cohort studies of limited sample size, or studies in populations outside Europe and North America. The purpose of this cohort study was to identify predictors for aneurysm multiplicity and to investigate the anatomic distribution of MIA in a representative Western cohort of patients with aSAH...
December 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29258400/evaluation-of-apoe-genotype-and-ability-to-perform-activities-of-daily-living-following-aneurysmal-subarachnoid-hemorrhage
#15
Lacey Wright Heinsberg, Eleanor Turi, Dianxu Ren, Elizabeth Crago, Sheila Alexander, Ansley Grimes Stanfill, Yvette Perry Conley
Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often experience unfavorable functional outcomes that result in a reduced ability to independently perform activities of daily living. The apolipoprotein E gene ( APOE) encodes for a protein known to facilitate lipid transport and aid in neuronal repair within the central nervous system and to moderate the inflammatory response, making functional variations in this gene likely candidate biomarkers to predict outcomes following aSAH. In the present work, we examined the relationship between APOE genotype and the ability to perform activities of daily living as measured by the Barthel Index (BI) score at 3 months ( n = 298) and 12 months ( n = 288) following aSAH...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/29243978/reduction-of-shunt-dependency-rates-following-aneurysmal-subarachnoid-hemorrhage-by-tandem-fenestration-of-the-lamina-terminalis-and-membrane-of-liliequist-during-microsurgical-aneurysm-repair
#16
Ethan A Winkler, Jan-Karl Burkhardt, W Caleb Rutledge, Jonathan W Rick, Carlene P Partow, John K Yue, Harjus Birk, Ashley M Bach, Kunal P Raygor, Michael T Lawton
OBJECTIVE Shunt-dependent hydrocephalus is an important cause of morbidity following aneurysmal subarachnoid hemorrhage (aSAH) in excess of 20% of cases. Hydrocephalus leads to prolonged hospital and ICU stays, well as to repeated surgical interventions, readmissions, and complications associated with ventriculoperitoneal (VP) shunts, including shunt failure and infection. Whether variations in surgical technique at the time of aneurysm treatment may modify rates of shunt dependency remains a matter of debate...
December 15, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29224114/coated-platelet-trends-predict-short-term-clinical-outcomeafter-subarachnoid-hemorrhage
#17
Bappaditya Ray, Vijay M Pandav, Eleanor A Mathews, David M Thompson, Lance Ford, Lori K Yearout, Bradley N Bohnstedt, Shuchi Chaudhary, George L Dale, Calin I Prodan
Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high socio-economic burden. Prothrombotic states of early brain injury (EBI) and delayed cerebral ischemia (DCI) after aSAH determine morbidity and mortality. To understand how activated platelets might contribute to such prothrombotic states, we studied trends in coated-platelets during EBI and DCI periods. Serial blood samples from a prospective cohort of aSAH patients were collected and assayed for coated-platelet levels. Patient's coated-platelet level during post-hospital discharge follow-up served as an estimate of baseline...
December 9, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29216792/quadriceps-muscle-thickness-changes-in-patients-with-aneurysmal-subarachnoid-hemorrhage-during-the-acute-phase
#18
Masafumi Nozoe, Masashi Kanai, Hiroki Kubo, Miki Kobayashi, Miho Yamamoto, Shinichi Shimada, Kyoshi Mase
Background Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition that often leads to severe disability in relatively young and healthy people. This disability is physical in many aSAH survivors, so muscle dysfunction may be an important factor in the functional level of these patients. Thus, measuring muscle thickness represents a suitable method for determining muscle function in patients with acute aSAH, because the disordered consciousness often experienced during the acute phase causes active movement to be difficult for these patients...
December 8, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29214784/contrast-induced-acute-kidney-injury-after-coil-embolization-for-aneurysmal-subarachnoid-hemorrhage
#19
Hyun Goo Lee, Won Ki Kim, Je Young Yeon, Jong Soo Kim, Keon Ha Kim, Pyoung Jeon, Seung Chyul Hong
PURPOSE: Contrast-induced acute kidney injury (CI-AKI) is associated with poor outcomes after percutaneous coronary intervention. However, CI-AKI has rarely been evaluated within the neurovascular field. The aim of this study was to investigate the incidence and clinical implication of CI-AKI after coil embolization in patients with an aneurysmal subarachnoid hemorrhage (aSAH). MATERIALS AND METHODS: Between January 2005 and March 2016, 192 patients who underwent coil embolization were enrolled in this study...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214402/decision-making-and-neurosurgeons-agreement-in-the-management-of-aneurysmal-subarachnoid-haemorrhage-based-on-computed-tomography-angiography
#20
Nicolai Maldaner, Jan-Karl Burkhardt, Martin Nikolaus Stienen, Johannes Goldberg, David Bervini, Philippe Bijlenga, Davide Croci, Daniel Zumofen, Donato D'Alonzo, Serge Marbacher, Rodolfo Maduri, Roy Thomas Daniel, Carlo Serra, Giuseppe Esposito, Marian C Neidert, Oliver Bozinov, Luca Regli
BACKGROUND: To determine the neurosurgeon's agreement in aneurysmal subarachnoid haemorrhage (aSAH) management with special emphasis on the rater's level of experience. A secondary aim was to analyse potential aneurysm variables associated with the therapeutic recommendation. METHOD: Basic clinical information and admission computed tomography angiography (CTA) images of 30 consecutive aSAH patients were provided. Twelve neurosurgeons independently evaluated aneurysm characteristics and gave recommendations regarding the emergency management and aneurysm occlusion therapy...
February 2018: Acta Neurochirurgica
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